Daniel N Darlington, Angel V Delgado, Bijan S Kheirabadi, Chriselda G Fedyk, Michael R Scherer, Anthony E Pusateri, Charles E Wade, Andrew P Cap, John B Holcomb, Michael A Dubick
BACKGROUND: This study evaluates the effect of hemodilution by various common resuscitation fluids, and the efficacy of activated recombinant factor VII (rFVIIa) on coagulation parameters in human blood in vitro. METHODS: Samples from normal healthy volunteers (n = 9) were hemodiluted from 0% to 90% with normal saline, or 0%, 40%, 60%, and 80% with 5% albumin, Hespan, Hextend, normal saline, or lactated Ringer's, and incubated at 37°C ± 1°C for 30 minutes with and without rFVIIa (1...
November 2011: Journal of Trauma