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Peter molenaar

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https://www.readbyqxmd.com/read/28428630/hinge-deleted-igg4-blocker-therapy-for-acetylcholine-receptor-myasthenia-gravis-in-rhesus-monkeys
#1
Mario Losen, Aran F Labrijn, Vivianne H van Kranen-Mastenbroek, Maarten L Janmaat, Krista G Haanstra, Frank J Beurskens, Tom Vink, Margreet Jonker, Bert A 't Hart, Marina Mané-Damas, Peter C Molenaar, Pilar Martinez-Martinez, Eline van der Esch, Janine Schuurman, Marc H de Baets, Paul W H I Parren
Autoantibodies against ion channels are the cause of numerous neurologic autoimmune disorders. Frequently, such pathogenic autoantibodies have a restricted epitope-specificity. In such cases, competing antibody formats devoid of pathogenic effector functions (blocker antibodies) have the potential to treat disease by displacing autoantibodies from their target. Here, we have used a model of the neuromuscular autoimmune disease myasthenia gravis in rhesus monkeys (Macaca mulatta) to test the therapeutic potential of a new blocker antibody: MG was induced by passive transfer of pathogenic acetylcholine receptor-specific monoclonal antibody IgG1-637...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28388963/minimally-invasive-versus-open-distal-pancreatectomy-leopard-study-protocol-for-a-randomized-controlled-trial
#2
Thijs de Rooij, Jony van Hilst, Jantien A Vogel, Hjalmar C van Santvoort, Marieke T de Boer, Djamila Boerma, Peter B van den Boezem, Bert A Bonsing, Koop Bosscha, Peter-Paul Coene, Freek Daams, Ronald M van Dam, Marcel G Dijkgraaf, Casper H van Eijck, Sebastiaan Festen, Michael F Gerhards, Bas Groot Koerkamp, Jeroen Hagendoorn, Erwin van der Harst, Ignace H de Hingh, Cees H Dejong, Geert Kazemier, Joost Klaase, Ruben H de Kleine, Cornelis J van Laarhoven, Daan J Lips, Misha D Luyer, I Quintus Molenaar, Vincent B Nieuwenhuijs, Gijs A Patijn, Daphne Roos, Joris J Scheepers, George P van der Schelling, Pascal Steenvoorde, Rutger-Jan Swijnenburg, Jan H Wijsman, Moh'd Abu Hilal, Olivier R Busch, Marc G Besselink
BACKGROUND: Observational cohort studies have suggested that minimally invasive distal pancreatectomy (MIDP) is associated with better short-term outcomes compared with open distal pancreatectomy (ODP), such as less intraoperative blood loss, lower morbidity, shorter length of hospital stay, and reduced total costs. Confounding by indication has probably influenced these findings, given that case-matched studies failed to confirm the superiority of MIDP. This accentuates the need for multicenter randomized controlled trials, which are currently lacking...
April 8, 2017: Trials
https://www.readbyqxmd.com/read/28319050/extracellular-matrix-proteomics-identifies-molecular-signature-of-symptomatic-carotid-plaques
#3
Sarah R Langley, Karin Willeit, Athanasios Didangelos, Ljubica Perisic Matic, Philipp Skroblin, Javier Barallobre-Barreiro, Mariette Lengquist, Gregor Rungger, Alexander Kapustin, Ludmilla Kedenko, Chris Molenaar, Ruifang Lu, Temo Barwari, Gonca Suna, Xiaoke Yin, Bernhard Iglseder, Bernhard Paulweber, Peter Willeit, Joseph Shalhoub, Gerard Pasterkamp, Alun H Davies, Claudia Monaco, Ulf Hedin, Catherine M Shanahan, Johann Willeit, Stefan Kiechl, Manuel Mayr
BACKGROUND: The identification of patients with high-risk atherosclerotic plaques prior to the manifestation of clinical events remains challenging. Recent findings question histology- and imaging-based definitions of the "vulnerable plaque," necessitating an improved approach for predicting onset of symptoms. METHODS: We performed a proteomics comparison of the vascular extracellular matrix and associated molecules in human carotid endarterectomy specimens from 6 symptomatic versus 6 asymptomatic patients to identify a protein signature for high-risk atherosclerotic plaques...
April 3, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28243453/selection-for-production-related-traits-in-pelargonium-zonale-improved-design-and-analysis-make-all-the-difference
#4
Heike Molenaar, Martin Glawe, Robert Boehm, Hans-Peter Piepho
Ornamental plant variety improvement is limited by current phenotyping approaches and neglected use of experimental designs. The present study was conducted to show the benefits of using an experimental design and corresponding analysis in ornamental breeding regarding simulated response to selection in Pelargonium zonale for production-related traits. This required establishment of phenotyping protocols for root formation and stem cutting counts, with which 974 genotypes were assessed in a two-phase experimental design...
2017: Horticulture Research
https://www.readbyqxmd.com/read/28241220/management-of-severe-pancreatic-fistula-after-pancreatoduodenectomy
#5
F Jasmijn Smits, Hjalmar C van Santvoort, Marc G Besselink, Marilot C T Batenburg, Robbert A E Slooff, Djamila Boerma, Olivier R Busch, Peter P L O Coene, Ronald M van Dam, David P J van Dijk, Casper H J van Eijck, Sebastiaan Festen, Erwin van der Harst, Ignace H J T de Hingh, Koert P de Jong, Johanna A M G Tol, Inne H M Borel Rinkes, I Quintus Molenaar
Importance: Postoperative pancreatic fistula is a potentially life-threatening complication after pancreatoduodenectomy. Evidence for best management is lacking. Objective: To evaluate the clinical outcome of patients undergoing catheter drainage compared with relaparotomy as primary treatment for pancreatic fistula after pancreatoduodenectomy. Design, Setting, and Participants: A multicenter, retrospective, propensity-matched cohort study was conducted in 9 centers of the Dutch Pancreatic Cancer Group from January 1, 2005, to September 30, 2013...
February 22, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28207288/equivalent-dynamic-models
#6
Peter C M Molenaar
Equivalences of two classes of dynamic models for weakly stationary multivariate time series are discussed: dynamic factor models and autoregressive models. It is shown that exploratory dynamic factor models can be rotated, yielding an infinite set of equivalent solutions for any observed series. It also is shown that dynamic factor models with lagged factor loadings are not equivalent to the currently popular state-space models, and that restriction of attention to the latter type of models may yield invalid results...
March 2017: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/27982700/-re-evaluating-the-implications-of-the-autoregressive-latent-trajectory-model-through-likelihood-ratio-tests-of-its-initial-conditions
#7
Lu Ou, Sy-Miin Chow, Linying Ji, Peter C M Molenaar
The autoregressive latent trajectory (ALT) model synthesizes the autoregressive model and the latent growth curve model. The ALT model is flexible enough to produce a variety of discrepant model-implied change trajectories. While some researchers consider this a virtue, others have cautioned that this may confound interpretations of the model's parameters. In this article, we show that some-but not all-of these interpretational difficulties may be clarified mathematically and tested explicitly via likelihood ratio tests (LRTs) imposed on the initial conditions of the model...
March 2017: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/27965060/igg4-autoantibodies-against-muscle-specific-kinase-undergo-fab-arm-exchange-in-myasthenia-gravis-patients
#8
Inga Koneczny, Jo A A Stevens, Anna De Rosa, Saif Huda, Maartje G Huijbers, Abhishek Saxena, Michelangelo Maestri, Konstantinos Lazaridis, Paraskevi Zisimopoulou, Socrates Tzartos, Jan Verschuuren, Silvère M van der Maarel, Philip van Damme, Marc H De Baets, Peter C Molenaar, Angela Vincent, Roberta Ricciardi, Pilar Martinez-Martinez, Mario Losen
Autoimmunity mediated by IgG4 subclass autoantibodies is an expanding field of research. Due to their structural characteristics a key feature of IgG4 antibodies is the ability to exchange Fab-arms with other, unrelated, IgG4 molecules, making the IgG4 molecule potentially monovalent for the specific antigen. However, whether those disease-associated antigen-specific IgG4 are mono- or divalent for their antigens is unknown. Myasthenia gravis (MG) with antibodies to muscle specific kinase (MuSK-MG) is a well-recognized disease in which the predominant pathogenic IgG4 antibody binds to extracellular epitopes on MuSK at the neuromuscular junction; this inhibits a pathway that clusters the acetylcholine (neurotransmitter) receptors and leads to failure of neuromuscular transmission...
February 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/27658713/silencing-of-dok-7-in-adult-rat-muscle-increases-susceptibility-to-passive-transfer-myasthenia-gravis
#9
Alejandro M Gomez, Jo A A Stevens, Marina Mané-Damas, Peter Molenaar, Hans Duimel, Fons Verheyen, Judith Cossins, David Beeson, Marc H De Baets, Mario Losen, Pilar Martinez-Martinez
Myasthenia gravis (MG) is an autoimmune disease mediated by autoantibodies that target proteins at the neuromuscular junction, primarily the acetylcholine receptor (AChR) and the muscle-specific kinase. Because downstream of kinase 7 (Dok-7) is essential for the full activation of muscle-specific kinase and consequently for dense clustering of AChRs, we hypothesized that reduced levels of Dok-7 increase the susceptibility to passive transfer MG. To test this hypothesis, Dok-7 expression was reduced by transfecting shRNA-coding plasmids into the tibialis anterior muscle of adult rats by in vivo electroporation...
October 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27644409/real-time-visual-feedback-of-com-and-cop-motion-properties-differentially-modifies-postural-control-structures
#10
Melissa C Kilby, Peter C M Molenaar, Semyon M Slobounov, Karl M Newell
The experiment was setup to investigate the control of human quiet standing through the manipulation of augmented visual information feedback of selective properties of the motion of two primary variables in postural control: center of pressure (COP) and center of mass (COM). Five properties of feedback information were contrasted to a no feedback dual-task (watching a movie) control condition to determine the impact of visual real-time feedback on the coordination of the joint motions in postural control in both static and dynamic one-leg standing postures...
September 19, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27272012/electromagnetic-guided-bedside-placement-of-nasoenteral-feeding-tubes-by-nurses-is-non-inferior-to-endoscopic-placement-by-gastroenterologists-a-multicenter-randomized-controlled-trial
#11
Arja Gerritsen, Thijs de Rooij, Marcel G Dijkgraaf, Olivier R Busch, Jacques J Bergman, Dirk T Ubbink, Peter van Duijvendijk, G Willemien Erkelens, Mariël Klos, Philip M Kruyt, Dirk Jan Bac, Camiel Rosman, Adriaan C Tan, I Quintus Molenaar, Jan F Monkelbaan, Elisabeth M Mathus-Vliegent, Marc G Besselink
OBJECTIVES: Electromagnetic (EM)-guided bedside placement of nasoenteral feeding tubes by nurses may improve efficiency and reduce patient discomfort and costs compared with endoscopic placement by gastroenterologists. However, evidence supporting this task shift from gastroenterologists to nurses is limited. We aimed to compare the effectiveness of EM-guided and endoscopic nasoenteral feeding tube placement. METHODS: We performed a multicenter randomized controlled non-inferiority trial in 154 adult patients who required nasoenteral feeding and were admitted to gastrointestinal surgical wards in five Dutch hospitals...
August 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27248831/some-behaviorial-science-measurement-concerns-and-proposals
#12
John R Nesselroade, Peter C M Molenaar
Primarily from a measurement standpoint, we question some basic beliefs and procedures characterizing the scientific study of human behavior. The relations between observed and unobserved variables are key to an empirical approach to building explanatory theories and we are especially concerned about how the former are used as proxies for the latter. We believe that behavioral science can profitably reconsider the prevailing version of this arrangement because of its vulnerability to limiting idiosyncratic aspects of observed/unobserved variable relations...
March 2016: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/27248685/a-rejoinder
#13
John R Nesselroade, Peter C M Molenaar
Three commentaries on the Nesselroade and Molenaar target article in this issue are responded to in the interest of elaborating and defending the points of view expressed in our article. The commentaries feature philosophy of science, general structural modeling, and broad behavioral research perspectives. Responding to the commentaries afforded us the opportunity to clarify further matters that we deem critical to the fundamental matter of measurement in behavioral science, especially as it emphasizes (properly, we believe) the individual as the primary unit of analysis...
March 2016: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/27165092/bridging-the-nomothetic-and-idiographic-approaches-to-the-analysis-of-clinical-data
#14
Adriene M Beltz, Aidan G C Wright, Briana N Sprague, Peter C M Molenaar
The nomothetic approach (i.e., the study of interindividual variation) dominates analyses of clinical data, even though its assumption of homogeneity across people and time is often violated. The idiographic approach (i.e., the study of intraindividual variation) is best suited for analyses of heterogeneous clinical data, but its person-specific methods and results have been criticized as unwieldy. Group iterative multiple model estimation (GIMME) combines the assets of the nomothetic and idiographic approaches by creating person-specific maps that contain a group-level structure...
August 2016: Assessment
https://www.readbyqxmd.com/read/27101164/tibial-plateau-fracture-characteristics-reliability-and-diagnostic-accuracy
#15
COMPARATIVE STUDY
Jos J Mellema, Job N Doornberg, Rik J Molenaars, David Ring, Peter Kloen
OBJECTIVES: The purpose of this study was to assess the interobserver reliability and diagnostic accuracy for 2-dimensional (2D) and 3-dimensional (3D) computed tomography (CT)-based evaluation of tibial plateau fracture characteristics. We hypothesized that recognition of specific tibial plateau fracture characteristics is equally reliable and accurate in 2DCT and 2D- and 3DCT. METHODS: Eighty-one orthopedic trauma surgeons and residents were randomized to either 2DCT or 2D- and 3DCT evaluation of 15 complex tibial plateau fractures using web-based platforms to recognize 4 tibial plateau fracture characteristics: (1) a posteromedial component, (2) a lateral component, (3) a tibial tubercle component, and (4) a tibial spine (central) component...
May 2016: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/27093380/dealing-with-multiple-solutions-in-structural-vector-autoregressive-models
#16
Adriene M Beltz, Peter C M Molenaar
Structural vector autoregressive models (VARs) hold great potential for psychological science, particularly for time series data analysis. They capture the magnitude, direction of influence, and temporal (lagged and contemporaneous) nature of relations among variables. Unified structural equation modeling (uSEM) is an optimal structural VAR instantiation, according to large-scale simulation studies, and it is implemented within an SEM framework. However, little is known about the uniqueness of uSEM results...
March 2016: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/27089068/long-term-outcomes-of-patients-with-recent-onset-rheumatoid-arthritis-after-10-years-of-tight-controlled-treatment-a-randomized-trial
#17
RANDOMIZED CONTROLLED TRIAL
Iris M Markusse, Gülsah Akdemir, Linda Dirven, Yvonne P M Goekoop-Ruiterman, Johannes H L M van Groenendael, K Huub Han, T H Esmeralda Molenaar, Saskia Le Cessie, Willem F Lems, Peter A H M van der Lubbe, Pit J S M Kerstens, André J Peeters, H Karel Ronday, Peter B J de Sonnaville, Irene Speyer, Theo Stijnen, Saskia Ten Wolde, Tom W J Huizinga, Cornelia F Allaart
BACKGROUND: Treat-to-target therapy is effective for patients with rheumatoid arthritis (RA), but long-term results of continued targeted treatment are lacking. OBJECTIVE: To evaluate long-term outcomes in patients with early RA after 10 years of targeted treatment in 4 treatment strategies. DESIGN: Randomized trial. (Nederlands Trial Register: NTR262 and NTR265). SETTING: The Netherlands. PATIENTS: 508 patients with early active RA...
April 19, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27040685/person-specific-non-shared-environmental-influences-in-intra-individual-variability-a-preliminary-case-of-daily-school-feelings-in-monozygotic-twins
#18
Yao Zheng, Peter C M Molenaar, Rosalind Arden, Kathryn Asbury, David M Almeida
Most behavioural genetic studies focus on genetic and environmental influences on inter-individual phenotypic differences at the population level. The growing collection of intensive longitudinal data in social and behavioural science offers a unique opportunity to examine genetic and environmental influences on intra-individual phenotypic variability at the individual level. The current study introduces a novel idiographic approach and one novel method to investigate genetic and environmental influences on intra-individual variability by a simple empirical demonstration...
September 2016: Behavior Genetics
https://www.readbyqxmd.com/read/26881957/testing-for-granger-causality-in-the-frequency-domain-a-phase-resampling-method
#19
Siwei Liu, Peter Molenaar
This article introduces phase resampling, an existing but rarely used surrogate data method for making statistical inferences of Granger causality in frequency domain time series analysis. Granger causality testing is essential for establishing causal relations among variables in multivariate dynamic processes. However, testing for Granger causality in the frequency domain is challenging due to the nonlinear relation between frequency domain measures (e.g., partial directed coherence, generalized partial directed coherence) and time domain data...
2016: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/26881950/editorial
#20
EDITORIAL
Peter Molenaar
No abstract text is available yet for this article.
2016: Multivariate Behavioral Research
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