keyword
https://read.qxmd.com/read/38630901/meta-analysis-of-the-difficulties-in-emotion-regulation-scale-and-its-short-forms-a%C3%A2-two-part-study
#1
JOURNAL ARTICLE
Giulia Raimondi, Michela Balsamo, Leonardo Carlucci, Fabio Alivernini, Fabio Lucidi, Tonia Samela, Marco Innamorati
The Difficulties in Emotion Regulation Scale (DERS) is the most used self-report questionnaire to assess deficits in emotion regulation (ER), composed of 6 dimensions and 36 items. Many studies have evaluated its factor structure, not always confirming the original results, and proposed different factor models. A possible way to try to identify the dimensionality of the DERS could be through a meta-analysis with structural equation models (MASEM) of its factor structure. The MASEM indicated that a six-factor model with 32 items (DERS-32) was the most suitable to represent the dimensionality of the DERS (χ2  = 2095...
April 17, 2024: Journal of Clinical Psychology
https://read.qxmd.com/read/38622947/development-and-validation-of-health-oriented-personal-evaluation-for-the-community-dwelling-older-person-based-on-the-international-classification-of-functioning-disability-and-health
#2
JOURNAL ARTICLE
Liang Zhou, Chun Feng, Yue Lu, Li-Juan Zhong, Jing Gao, Na Liu, Feng Lin, Zhong-Li Jiang
BACKGROUND: The International Classification of Functioning, Disability and Health (ICF) offers a standardized international terminology to operationalize function management across multiple domains, but the summary score of the ICF qualifier scale provides limited information on the comparison of personal abilities and functioning difficulties. OBJECTIVES: To enhance the interpretative power of the ICF-based Health-oriented Personal Evaluation for the community-dwelling older person (iHOPE-OP) scale through the implementation of the item response theory (IRT) modelling...
May 2024: International Journal of Older People Nursing
https://read.qxmd.com/read/38606874/defining-the-minimal-and-optimal-thresholds-for-lymph-node-resection-and-examination-for-intraductal-papillary-mucinous-neoplasm-derived-pancreatic-cancer-a-multicenter-retrospective-analysis
#3
JOURNAL ARTICLE
Joseph R Habib, Ingmar F Rompen, Sarah R Kaslow, Mahip Grewal, Paul C M Andel, Shuang Zhang, D Brock Hewitt, Steven M Cohen, Hjalmar C van Santvoort, Marc G Besselink, I Quintus Molenaar, Jin He, Christopher L Wolfgang, Ammar A Javed, Lois A Daamen
OBJECTIVE: To establish minimal and optimal lymphadenectomy thresholds for intraductal papillary mucinous neoplasm (IPMN)-derived pancreatic ductal adenocarcinoma (PDAC) and evaluate their prognostic value. BACKGROUND: Current guidelines recommend a minimum of 12-15 lymph nodes (LNs) in PDAC. This is largely based on pancreatic intraepithelial neoplasia (PanIN)-derived PDAC, a biologically distinct entity from IPMN-derived PDAC. METHODS: Multicenter retrospective study including consecutive patients undergoing upfront surgery for IPMN-derived PDAC was conducted...
April 12, 2024: Annals of Surgery
https://read.qxmd.com/read/38572655/extensive-genetic-and-biological-characterization-of-infectious-bronchitis-virus-strain-d2860-of-genotype-gviii
#4
JOURNAL ARTICLE
R J Molenaar, R Dijkman, I Jorna, J J de Wita
Infectious bronchitis virus (IBV) strains of genotype GVIII have been emerging in Europe in the last decade, but no biological characterisation has been reported so far. This paper reports the extensive genetic and biological characterization of IBV strain D2860 of genotype GVIII that was isolated from a Dutch layer flock that showed a drop in egg production. Whole genome sequencing showed that it has a high similarity (95%) to CK/DE/IB80/2016 (commonly known as IB80). Cross-neutralization tests with antigens and serotype-specific antisera of a panel different non-GVIII genotypes consistently gave less than 2% antigenic cross-relationship with D2860...
April 4, 2024: Avian Pathology: Journal of the W.V.P.A
https://read.qxmd.com/read/38570225/robot-assisted-versus-laparoscopic-pancreatoduodenectomy-a-pan-european-multicenter-propensity-matched-study
#5
JOURNAL ARTICLE
Anouk M L H Emmen, Maurice J W Zwart, Igor E Khatkov, Ugo Boggi, Bas Groot Koerkamp, Olivier R Busch, Olivier Saint-Marc, Safi Dokmak, I Quintus Molenaar, Mathieu D'Hondt, Marco Ramera, Tobias Keck, Giovanni Ferrari, Misha D P Luyer, Luca Moraldi, Benedetto Ielpo, Uwe Wittel, Francois-Regis Souche, Thilo Hackert, Daan Lips, Mehmet Fatih Can, Koop Bosscha, Regis Fara, Sebastiaan Festen, Susan van Dieren, Andrea Coratti, Ignace De Hingh, Michele Mazzola, Ulrich Wellner, Celine De Meyere, Hjalmar C van Santvoort, Béatrice Aussilhou, Abdallah Ibenkhayat, Roeland F de Wilde, Emanuele F Kauffmann, Pavel Tyutyunnik, Marc G Besselink, Mohammad Abu Hilal
BACKGROUND: The use of robot-assisted and laparoscopic pancreatoduodenectomy is increasing, yet large adjusted analyses that can be generalized internationally are lacking. This study aimed to compare outcomes after robot-assisted pancreatoduodenectomy and laparoscopic pancreatoduodenectomy in a pan-European cohort. METHODS: An international multicenter retrospective study including patients after robot-assisted pancreatoduodenectomy and laparoscopic pancreatoduodenectomy from 50 centers in 12 European countries (2009-2020)...
April 2, 2024: Surgery
https://read.qxmd.com/read/38557955/evaluation-of-short-and-long-term-outcomes-after-resection-in-patients-with-locally-advanced-versus-borderline-resectable-pancreatic-cancer
#6
JOURNAL ARTICLE
Lilly J H Brada, Thijs J Schouten, Lois A Daamen, Leonard W F Seelen, Marieke S Walma, Ronald van Dam, Ignace H de Hingh, Mike S L Liem, Vincent E de Meijer, Gijs A Patijn, Sebastiaan Festen, Martijn W J Stommel, Koop Bosscha, Marc G Besselink, Hjalmar C van Santvoort, Izaak Quintus Molenaar
OBJECTIVE: This study aims to evaluate short- and long-term outcomes following pancreatectomy in patients with LAPC compared to (B)RPC patients. SUMMARY BACKGROUND DATA: Selected patients diagnosed with locally advanced pancreatic cancer (LAPC) are increasingly undergoing resection following induction chemotherapy. To evaluate the benefit of this treatment approach, it is helpful to compare outcomes in resected patients with primary LAPC to outcomes in resected patients with primary (borderline) resectable pancreatic cancer ((B)RPC)...
April 1, 2024: Annals of Surgery
https://read.qxmd.com/read/38541904/the-difficulty-of-detecting-occult-metastases-in-patients-with-potentially-resectable-pancreatic-cancer-development-and-external-validation-of-a-preoperative-prediction-model
#7
JOURNAL ARTICLE
Marieke Walma, Laura Maggino, F Jasmijn Smits, Alicia S Borggreve, Lois A Daamen, Vincent P Groot, Fabio Casciani, Vincent E de Meijer, Frank J Wessels, George P van der Schelling, Vincent B Nieuwenhuijs, Koop Bosscha, Erwin van der Harst, Ronald van Dam, Mike S Liem, Sebastiaan Festen, Martijn W J Stommel, Daphne Roos, Fennie Wit, Ignace H de Hingh, Bert A Bonsing, Olivier R Busch, Bas Groot Koerkamp, Geert Kazemier, Marc G Besselink, Roberto Salvia, Giuseppe Malleo, I Quintus Molenaar, Hjalmar C van Santvoort
Occult metastases are detected in 10-15% of patients during exploratory laparotomy for pancreatic cancer. This study developed and externally validated a model to predict occult metastases in patients with potentially resectable pancreatic cancer. Model development was performed within the Dutch Pancreatic Cancer Audit, including all patients operated for pancreatic cancer (January 2013-December 2017). Multivariable logistic regression analysis based on the Akaike Information Criteria was performed with intraoperative pathologically proven metastases as the outcome...
March 14, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38520782/multimodal-prehabilitation-in-elective-oncological-colorectal-surgery-enhances-postoperative-functional-recovery-a-secondary-analysis-of-the-prehab-randomized-clinical-trial
#8
JOURNAL ARTICLE
David W G Ten Cate, Charlotte J L Molenaar, Raquel Sebio Garcia, Rasmus D Bojesen, Bhagya Lakshmi Ramappa Tahasildar, Loes Jansen, Manuel López-Baamonde, Carlo Vittorio Feo, Graciela Martínez-Palli, Ismail Gögenur, Francesco Carli, Gerrit D Slooter
INTRODUCTION: Colorectal cancer (CRC) ranks as the second leading cause of cancer-related deaths. The PREHAB trial revealed that prehabilitation in colorectal surgery leads to a reduction of severe complications and enhanced functional capacity. Nevertheless, risk selection for prehabilitation and the potential benefits for patients without postoperative complications remains unclear. This study aims to assess postoperative functional capacity, also in patients without postoperative complications...
March 20, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38499019/prophylactic-abdominal-drainage-after-distal-pancreatectomy-pandorina-an-international-multicentre-open-label-randomised-controlled-non-inferiority-trial
#9
JOURNAL ARTICLE
Eduard A van Bodegraven, Alberto Balduzzi, Tess M E van Ramshorst, Giuseppe Malleo, Frederique L Vissers, Jony van Hilst, Sebastiaan Festen, Mohammad Abu Hilal, Horacio J Asbun, Nynke Michiels, Bas Groot Koerkamp, Olivier R C Busch, Freek Daams, Misha D P Luyer, Marco Ramera, Giovanni Marchegiani, Joost M Klaase, I Quintus Molenaar, Matteo de Pastena, Gabriella Lionetto, Pier Giuseppe Vacca, Hjalmar C van Santvoort, Martijn W J Stommel, Daan J Lips, Mariëlle M E Coolsen, J Sven D Mieog, Roberto Salvia, Casper H J van Eijck, Marc G Besselink
BACKGROUND: Prophylactic passive abdominal drainage is standard practice after distal pancreatectomy. This approach aims to mitigate the consequences of postoperative pancreatic fistula (POPF) but its added value, especially in patients at low risk of POPF, is currently being debated. We aimed to assess the non-inferiority of a no-drain policy in patients after distal pancreatectomy. METHODS: In this international, multicentre, open-label, randomised controlled, non-inferiority trial, we recruited patients aged 18 years or older undergoing open or minimally invasive elective distal pancreatectomy for all indications in 12 centres in the Netherlands and Italy...
March 15, 2024: Lancet. Gastroenterology & Hepatology
https://read.qxmd.com/read/38498397/minimally-invasive-robot-assisted-and-laparoscopic-distal-pancreatectomy-in-a-pan-european-registry-a-retrospective-cohort-study
#10
JOURNAL ARTICLE
Eduard A van Bodegraven, Tess M E van Ramshorst, Svein O Bratlie, Arto Kokkola, Ernesto Sparrelid, Bergthor Björnsson, Dyre Kleive, Stefan K Burgdorf, Safi Dokmak, Bas Groot Koerkamp, Santiago Sánchez Cabús, I Quintus Molenaar, Ugo Boggi, Olivier R Busch, Miha Petrič, Geert Roeyen, Thilo Hackert, Daan J Lips, Mathieu D'Hondt, Mariëlle M E Coolsen, Giovanni Ferrari, Bobby Tingstedt, Alejandro Serrablo, Sebastien Gaujoux, Marco Ramera, Igor Khatkov, Fabio Ausania, Regis Souche, Sebastiaan Festen, Frederik Berrevoet, Tobias Keck, Robert P Sutcliffe, Elizabeth Pando, Roeland F de Wilde, Beatrice Aussilhou, Paul S Krohn, Bjørn Edwin, Per Sandström, Stefan Gilg, Hanna Seppänen, Caroline Vilhav, Mohammad Abu Hilal, Marc G Besselink
BACKGROUND: International guidelines recommend monitoring of the use and outcome of minimally invasive pancreatic surgery (MIPS). However, data from prospective international audits on minimally invasive distal pancreatectomy (MIDP) are lacking. This study examined the use and outcome of robot-assisted (RDP) and laparoscopic (LDP) distal pancreatectomy in the E-MIPS registry. MATERIALS AND METHODS: Post-hoc analysis in a prospective audit on MIPS, including consecutive patients undergoing MIDP in 83 centers from 19 European countries (01-01-2019/31-12-2021)...
March 18, 2024: International Journal of Surgery
https://read.qxmd.com/read/38485455/-31-p-mr-spectroscopy-in-the-pancreas-repeatability-comparison-with-liver-and-pilot-pancreatic-cancer-data
#11
JOURNAL ARTICLE
Leonard W F Seelen, Lieke van den Wildenberg, Ayhan Gursan, Martijn Froeling, Mark W J M Gosselink, Wybe J M van der Kemp, Nadia Haj Mohammad, I Quintus Molenaar, Hjalmar C van Santvoort, Dennis W J Klomp, Jeanine J Prompers
BACKGROUND: Non-invasive evaluation of phosphomonoesters (PMEs) and phosphodiesters (PDEs) by 31-phosphorus MR spectroscopy (31 P MRS) may have potential for early therapy (non-)response assessment in cancer. However, 31 P MRS has not yet been applied to investigate the human pancreas in vivo. PURPOSE: To assess the technical feasibility and repeatability of 31 P MR spectroscopic imaging (MRSI) of the pancreas, compare 31 P metabolite levels between pancreas and liver, and determine the feasibility of 31 P MRSI in pancreatic cancer...
March 14, 2024: Journal of Magnetic Resonance Imaging: JMRI
https://read.qxmd.com/read/38477370/multimodal-prehabilitation-in-elective-oncological-colorectal-surgery-enhances-preoperative-physical-fitness-a-single-center-prospective-real-world-data-analysis
#12
JOURNAL ARTICLE
David W G Ten Cate, Charissa R Sabajo, Charlotte J L Molenaar, Loes Janssen, Bart C Bongers, Gerrit D Slooter
BACKGROUND: Surgery can lead to curation in colorectal cancer (CRC) but is associated with significant morbidity. Prehabilitation plays an important role in increasing preoperative physical fitness to reduce morbidity risk; however, data from real-world practice is scarce. This study aimed to evaluate the change in preoperative physical fitness and to evaluate which patients benefit most from prehabilitation. MATERIALS AND METHODS: In this single-arm prospective cohort study, consecutive patients undergoing elective colorectal oncological surgery were offered a 3- to 4-week multimodal prehabilitation program (supervised physical exercise training, dietary consultation, protein and vitamin supplementation, smoking cessation, and psychological support)...
February 21, 2024: Acta Oncologica
https://read.qxmd.com/read/38448277/preoperative-chemoradiotherapy-but-not-chemotherapy-is-associated-with-reduced-risk-of-postoperative-pancreatic-fistula-after-pancreatoduodenectomy-for-pancreatic-ductal-adenocarcinoma-a-nationwide-analysis
#13
JOURNAL ARTICLE
Leonoor V Wismans, J Annelie Suurmeijer, Jelle C van Dongen, Bert A Bonsing, Hjalmar C Van Santvoort, Johanna W Wilmink, Geertjan van Tienhoven, Ignace H de Hingh, Daan J Lips, Erwin van der Harst, Vincent E de Meijer, Gijs A Patijn, Koop Bosscha, Martijn W Stommel, Sebastiaan Festen, Marcel den Dulk, Joost J Nuyttens, Martijn P W Intven, Judith de Vos-Geelen, I Quintus Molenaar, Olivier R Busch, Bas Groot Koerkamp, Marc G Besselink, Casper H J van Eijck
BACKGROUND: Postoperative pancreatic fistula remains the leading cause of significant morbidity after pancreatoduodenectomy for pancreatic ductal adenocarcinoma. Preoperative chemoradiotherapy has been described to reduce the risk of postoperative pancreatic fistula, but randomized trials on neoadjuvant treatment in pancreatic ductal adenocarcinoma focus increasingly on preoperative chemotherapy rather than preoperative chemoradiotherapy. This study aimed to investigate the impact of preoperative chemotherapy and preoperative chemoradiotherapy on postoperative pancreatic fistula and other pancreatic-specific surgery related complications on a nationwide level...
March 5, 2024: Surgery
https://read.qxmd.com/read/38415878/early-experience-with-robotic-pancreatoduodenectomy-versus-open-pancreatoduodenectomy-nationwide-propensity-score-matched-analysis
#14
JOURNAL ARTICLE
Nine de Graaf, Maurice J W Zwart, Jony van Hilst, Bram van den Broek, Bert A Bonsing, Olivier R Busch, Peter-Paul L O Coene, Freek Daams, Susan van Dieren, Casper H J van Eijck, Sebastiaan Festen, Ignace H J T de Hingh, Daan J Lips, Misha D P Luyer, J Sven D Mieog, Hjalmar C van Santvoort, George P van der Schelling, Martijn W J Stommel, Roeland F de Wilde, I Quintus Molenaar, Bas Groot Koerkamp, Marc G Besselink
BACKGROUND: Although robotic pancreatoduodenectomy has shown promising outcomes in experienced high-volume centres, it is unclear whether implementation on a nationwide scale is safe and beneficial. The aim of this study was to compare the outcomes of the early experience with robotic pancreatoduodenectomy versus open pancreatoduodenectomy in the Netherlands. METHODS: This was a nationwide retrospective cohort study of all consecutive patients who underwent robotic pancreatoduodenectomy or open pancreatoduodenectomy who were registered in the mandatory Dutch Pancreatic Cancer Audit (18 centres, 2014-2021), starting from the first robotic pancreatoduodenectomy procedure per centre...
January 31, 2024: British Journal of Surgery
https://read.qxmd.com/read/38386198/the-value-of-biological-and-conditional-factors-for-staging-of-patients-with-resectable-pancreatic-cancer-undergoing-upfront-resection-a-nationwide-analysis
#15
JOURNAL ARTICLE
Thijs J Schouten, Iris W J M van Goor, Galina A Dorland, Marc G Besselink, Bert A Bonsing, Koop Bosscha, Lodewijk A A Brosens, Olivier R Busch, Geert A Cirkel, Ronald M van Dam, Sebastiaan Festen, Bas Groot Koerkamp, Erwin van der Harst, Ignace H J T de Hingh, Martijn P W Intven, Geert Kazemier, Mike S L Liem, Krijn P van Lienden, Maartje Los, Vincent E de Meijer, Gijs A Patijn, Jennifer M J Schreinemakers, Martijn W J Stommel, Geert Jan van Tienhoven, Robert C Verdonk, Helena M Verkooijen, Hjalmar C van Santvoort, I Quintus Molenaar, Lois A Daamen
BACKGROUND: Novel definitions suggest that resectability status for pancreatic ductal adenocarcinoma (PDAC) should be assessed beyond anatomical criteria, considering both biological and conditional factors. This has, however, yet to be validated on a nationwide scale. This study evaluated the prognostic value of biological and conditional factors for staging of patients with resectable PDAC. PATIENTS AND METHODS: A nationwide observational cohort study was performed, including all consecutive patients who underwent upfront resection of National Comprehensive Cancer Network resectable PDAC in the Netherlands (2014-2019) with complete information on preoperative carbohydrate antigen (CA) 19-9 and Eastern Cooperative Oncology Group (ECOG) performance status...
February 22, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38373275/brody-disease-an-early-onset-myopathy-with-delayed-relaxation-and-abnormal-gait-a-case-series-of-9-children
#16
JOURNAL ARTICLE
Jamie I Verhoeven, Jasper Kramer, Juergen Seeger, Joery P Molenaar, Hilde Braakman, Erik-Jan Kamsteeg, Richard J Rodenburg, Benno Kusters, Suzanne Koudijs, Baziel G Van Engelen, Corrie E Erasmus, Nicol C Voermans
Brody disease is a rare autosomal recessive myopathy, caused by pathogenic variants in the ATP2A1 gene. It is characterized by an exercise-induced delay in muscle relaxation, often reported as muscle stiffness. Children may manifest with an abnormal gait and difficulty running. Delayed relaxation is commonly undetected, resulting in a long diagnostic delay. Almost all published cases so far were adults with childhood onset and adult diagnosis. With diagnostic next-generation sequencing, an increasing number of patients are diagnosed in childhood...
March 12, 2024: Neurology
https://read.qxmd.com/read/38299595/kbtbd13-is-an-actin-binding-protein-that-modulates-muscle-kinetics
#17
JOURNAL ARTICLE
Josine M de Winter, Joery P Molenaar, Michaela Yuen, Robbert van der Pijl, Shengyi Shen, Stefan Conijn, Martijn van de Locht, Menne Willigenburg, Sylvia Jp Bogaards, Esmee Sb van Kleef, Saskia Lassche, Malin Persson, Dilson E Rassier, Tamar E Sztal, Avnika A Ruparelia, Viola Oorschot, Georg Ramm, Thomas E Hall, Zherui Xiong, Christopher N Johnson, Frank Li, Balazs Kiss, Noelia Lozano-Vidal, Reinier A Boon, Manuela Marabita, Leonardo Nogara, Bert Blaauw, Richard J Rodenburg, Benno Küsters, Jonne Doorduin, Alan H Beggs, Henk Granzier, Ken Campbell, Weikang Ma, Thomas Irving, Edoardo Malfatti, Norma B Romero, Robert J Bryson-Richardson, Baziel Gm van Engelen, Nicol C Voermans, Coen Ac Ottenheijm
No abstract text is available yet for this article.
February 1, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38298739/-90-y-166-ho-radiation-lobectomy-for-liver-tumors-induces-abnormal-morphology-and-impaired-drainage-of-peritumor-lymphatics
#18
JOURNAL ARTICLE
Daan Andel, Lotte van den Bent, Marnix Gerard Ernest Hendrik Lam, Maarten Leonard Johannes Smits, Isaac Quintus Molenaar, Joep de Bruijne, Miangela Marie Laclé, Onno Kranenburg, Inne Hildbrand Max Borel Rinkes, Jeroen Hagendoorn
BACKGROUND & AIMS: High-dose unilobar radioembolization, or 'radiation lobectomy' (RL), is an induction therapy that achieves contralateral future liver remnant hypertrophy while simultaneously irradiating the tumor. As such, it may prevent further growth, but it is unknown whether RL affects intrahepatic lymphatics, a major route via which liver tumors disseminate. METHODS: This was a case-control study conducted at University Medical Center Utrecht. The study compared lymph vessels in livers that had undergone RL (cases) with those in livers that had not undergone RL (controls)...
February 2024: JHEP reports: innovation in hepatology
https://read.qxmd.com/read/38265434/implementation-and-outcome-of-minimally-invasive-pancreatoduodenectomy-in-europe-a-registry-based-retrospective-study-a-critical-appraisal-of-the-first-3-years-of-the-e-mips-registry
#19
JOURNAL ARTICLE
Anouk M L H Emmen, Nine de Graaf, I E Khatkov, O R Busch, S Dokmak, Ugo Boggi, Bas Groot Koerkamp, Giovanni Ferrari, I Q Molenaar, Olivier Saint-Marc, Marco Ramera, Daan J Lips, J S D Mieog, Misha D P Luyer, Tobias Keck, Mathieu D'Hondt, F R Souche, Bjørn Edwin, Thilo Hackert, M S L Liem, Abdallah Iben-Khayat, H C van Santvoort, Michele Mazzola, Roeland F de Wilde, E F Kauffmann, Beatrice Aussilhou, Sebastiaan Festen, R Izrailov, P Tyutyunnik, M G Besselink, Mohammad Abu Hilal
BACKGROUND: International multicenter audit-based studies focusing on the outcome of minimally invasive pancreatoduodenectomy (MIPD) are lacking. The European registry for Minimally Invasive Pancreatic Surgery (E-MIPS) is the E-AHPBA endorsed registry aimed to monitor and safeguard the introduction of MIPD in Europe. MATERIALS AND METHODS: A planned analysis of outcomes among consecutive patients after MIPD from 45 centers in 14 European countries in the E-MIPS registry (2019-2021)...
January 24, 2024: International Journal of Surgery
https://read.qxmd.com/read/38181797/integrative-analysis-of-neuroblastoma-by-single-cell-rna-sequencing-identifies-the-nectin2-tigit-axis-as-a-target-for-immunotherapy
#20
JOURNAL ARTICLE
Judith Wienke, Lindy L Visser, Waleed M Kholosy, Kaylee M Keller, Marta Barisa, Evon Poon, Sophie Munnings-Tomes, Courtney Himsworth, Elizabeth Calton, Ana Rodriguez, Ronald Bernardi, Femke van den Ham, Sander R van Hooff, Yvette A H Matser, Michelle L Tas, Karin P S Langenberg, Philip Lijnzaad, Anne L Borst, Elisa Zappa, Francisca J Bergsma, Josephine G M Strijker, Bronte M Verhoeven, Shenglin Mei, Amira Kramdi, Restuadi Restuadi, Alvaro Sanchez-Bernabeu, Annelisa M Cornel, Frank C P Holstege, Juliet C Gray, Godelieve A M Tytgat, Marijn A Scheijde-Vermeulen, Marc H W A Wijnen, Miranda P Dierselhuis, Karin Straathof, Sam Behjati, Wei Wu, Albert J R Heck, Jan Koster, Stefan Nierkens, Isabelle Janoueix-Lerosey, Ronald R de Krijger, Ninib Baryawno, Louis Chesler, John Anderson, Hubert N Caron, Thanasis Margaritis, Max M van Noesel, Jan J Molenaar
Pediatric patients with high-risk neuroblastoma have poor survival rates and urgently need more effective treatment options with less side effects. Since novel and improved immunotherapies may fill this need, we dissect the immunoregulatory interactions in neuroblastoma by single-cell RNA-sequencing of 24 tumors (10 pre- and 14 post-chemotherapy, including 5 pairs) to identify strategies for optimizing immunotherapy efficacy. Neuroblastomas are infiltrated by natural killer (NK), T and B cells, and immunosuppressive myeloid populations...
February 12, 2024: Cancer Cell
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