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Molenaar, p

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https://www.readbyqxmd.com/read/27920244/are-the-registry-data-reliable-an-audit-of-a-regional-trauma-registry-in-the-netherlands
#1
E E Horton, P Krijnen, H M Molenaar, I B Schipper
OBJECTIVE: Data in trauma registries need to be reliable when used for evaluation of injury management, trauma protocols and hospital statistics. The aim of this audit was to analyse the reliability of the data in the Trauma Centre West Netherlands (TCWN) region. DESIGN: Routinely registered trauma patients from all nine hospitals in the TCWN region were re-registered by a registrar for analysis. SETTING: Nine hospitals in the TCWN region in the Netherlands...
December 4, 2016: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/27847657/rare-case-of-an-epithelial-cyst-in-an-intrapancreatic-accessory-spleen-treated-by-robot-assisted-spleen-preserving-distal-pancreatectomy
#2
Willemijn P M van Dijck, Vincent P Groot, Lodewijk A A Brosens, Jeroen Hagendoorn, Inne H M Borel Rinkes, Maarten S van Leeuwen, I Quintus Molenaar
Epithelial cyst in an intrapancreatic accessory spleen (ECIPAS) is exceedingly rare with only 57 cases reported since the first publication in 1980. Comprehensive clinical and diagnostic features remain to be clarified. We present a case of ECIPAS in a 21-year-old Philippine woman who was admitted with right upper quadrant abdominal pain. A cystic lesion in the pancreatic tail was discovered and evaluated by computed tomography and magnetic resonance images. Based on clinical and radiological features a solid pseudopapillary neoplasm was suspected...
2016: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/27741008/impact-of-a-nationwide-training-program-in-minimally-invasive-distal-pancreatectomy-laelaps
#3
Thijs de Rooij, Jony van Hilst, Djamila Boerma, Bert A Bonsing, Freek Daams, Ronald M van Dam, Marcel G Dijkgraaf, Casper H van Eijck, Sebastiaan Festen, Michael F Gerhards, Bas Groot Koerkamp, Erwin van der Harst, Ignace H de Hingh, Geert Kazemier, Joost Klaase, Ruben H de Kleine, Cornelis J van Laarhoven, Daan J Lips, Misha D Luyer, I Quintus Molenaar, Gijs A Patijn, Daphne Roos, Joris J Scheepers, George P van der Schelling, Pascal Steenvoorde, Menno R Vriens, Jan H Wijsman, Dirk J Gouma, Olivier R Busch, Mohammed Abu Hilal, Marc G Besselink
OBJECTIVE: To study the feasibility and impact of a nationwide training program in minimally invasive distal pancreatectomy (MIDP). SUMMARY OF BACKGROUND DATA: Superior outcomes of MIDP compared with open distal pancreatectomy have been reported. In the Netherlands (2005 to 2013) only 10% of distal pancreatectomies were in a minimally invasive fashion and 85% of surgeons welcomed MIDP training. The feasibility and impact of a nationwide training program is unknown...
November 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27699793/genetic-architecture-of-plant-stress-resistance-multi-trait-genome-wide-association-mapping
#4
Manus P M Thoen, Nelson H Davila Olivas, Karen J Kloth, Silvia Coolen, Ping-Ping Huang, Mark G M Aarts, Johanna A Bac-Molenaar, Jaap Bakker, Harro J Bouwmeester, Colette Broekgaarden, Johan Bucher, Jacqueline Busscher-Lange, Xi Cheng, Emilie F Fradin, Maarten A Jongsma, Magdalena M Julkowska, Joost J B Keurentjes, Wilco Ligterink, Corné M J Pieterse, Carolien Ruyter-Spira, Geert Smant, Christa Testerink, Björn Usadel, Joop J A van Loon, Johan A van Pelt, Casper C van Schaik, Saskia C M van Wees, Richard G F Visser, Roeland Voorrips, Ben Vosman, Dick Vreugdenhil, Sonja Warmerdam, Gerrie L Wiegers, Joost van Heerwaarden, Willem Kruijer, Fred A van Eeuwijk, Marcel Dicke
Plants are exposed to combinations of various biotic and abiotic stresses, but stress responses are usually investigated for single stresses only. Here, we investigated the genetic architecture underlying plant responses to 11 single stresses and several of their combinations by phenotyping 350 Arabidopsis thaliana accessions. A set of 214 000 single nucleotide polymorphisms (SNPs) was screened for marker-trait associations in genome-wide association (GWA) analyses using tailored multi-trait mixed models. Stress responses that share phytohormonal signaling pathways also share genetic architecture underlying these responses...
October 4, 2016: New Phytologist
https://www.readbyqxmd.com/read/27460417/identification-of-a-novel-inactivating-mutation-in-isocitrate-dehydrogenase-1-idh1-r314c-in-a-high-grade-astrocytoma
#5
Sanne A M van Lith, Anna C Navis, Krissie Lenting, Kiek Verrijp, Jan T G Schepens, Wiljan J A J Hendriks, Nil A Schubert, Hanka Venselaar, Ron A Wevers, Arno van Rooij, Pieter Wesseling, Remco J Molenaar, Cornelis J F van Noorden, Stefan Pusch, Bastiaan Tops, William P J Leenders
The majority of low-grade and secondary high-grade gliomas carry heterozygous hotspot mutations in cytosolic isocitrate dehydrogenase 1 (IDH1) or the mitochondrial variant IDH2. These mutations mostly involve Arg132 in IDH1, and Arg172 or Arg140 in IDH2. Whereas IDHs convert isocitrate to alpha-ketoglutarate (α-KG) with simultaneous reduction of NADP(+) to NADPH, these IDH mutants reduce α-KG to D-2-hydroxyglutarate (D-2-HG) while oxidizing NADPH. D-2-HG is a proposed oncometabolite, acting via competitive inhibition of α-KG-dependent enzymes that are involved in metabolism and epigenetic regulation...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27429027/impact-of-a-nationwide-training-program-in-minimally-invasive-distal-pancreatectomy-laelaps
#6
Thijs de Rooij, Jony van Hilst, Djamila Boerma, Bert A Bonsing, Freek Daams, Ronald M van Dam, Marcel G Dijkgraaf, Casper H van Eijck, Sebastiaan Festen, Michael F Gerhards, Bas Groot Koerkamp, Erwin van der Harst, Ignace H de Hingh, Geert Kazemier, Joost Klaase, Ruben H de Kleine, Cornelis J van Laarhoven, Daan J Lips, Misha D Luyer, I Quintus Molenaar, Gijs A Patijn, Daphne Roos, Joris J Scheepers, George P van der Schelling, Pascal Steenvoorde, Menno R Vriens, Jan H Wijsman, Dirk J Gouma, Olivier R Busch, Mohammed Abu Hilal, Marc G Besselink
OBJECTIVE: To study the feasibility and impact of a nationwide training program in minimally invasive distal pancreatectomy (MIDP). SUMMARY OF BACKGROUND DATA: Superior outcomes of MIDP compared with open distal pancreatectomy have been reported. In the Netherlands (2005 to 2013) only 10% of distal pancreatectomies were in a minimally invasive fashion and 85% of surgeons welcomed MIDP training. The feasibility and impact of a nationwide training program is unknown...
August 1, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27403336/does-body-mass-index-bmi-influence-the-ankylosing-spondylitis-disease-activity-score-in-axial-spondyloarthritis-data-from-the-space-cohort
#7
Roxana Rubio Vargas, Rosaline van den Berg, Miranda van Lunteren, Zineb Ez-Zaitouni, Pauline A C Bakker, Hanne Dagfinrud, Roberta Ramonda, Robert Landewé, Esmeralda Molenaar, Floris A van Gaalen, Désirée van der Heijde
OBJECTIVE: Obesity is associated with elevated C reactive protein (CRP) levels. The Ankylosing Spondylitis Disease Activity Score (ASDAS) combines patient-reported outcomes (PROs) and CRP. We evaluated the effect of body mass index (BMI) on CRP and on ASDAS, and studied if ASDAS can be used in obese axial spondyloarthritis (axSpA) patients to assess disease activity. METHODS: Baseline data of patients with chronic back pain of short duration included in the SPondyloArthritis Caught Early (SPACE) cohort were used...
2016: RMD Open
https://www.readbyqxmd.com/read/27374773/mutations-in-complex-i-assembly-factor-tmem126b-result-in-muscle-weakness-and-isolated-complex-i-deficiency
#8
Laura Sánchez-Caballero, Benedetta Ruzzenente, Lucas Bianchi, Zahra Assouline, Giulia Barcia, Metodi D Metodiev, Marlène Rio, Benoît Funalot, Mariël A M van den Brand, Sergio Guerrero-Castillo, Joery P Molenaar, David Koolen, Ulrich Brandt, Richard J Rodenburg, Leo G Nijtmans, Agnès Rötig
Mitochondrial complex I deficiency results in a plethora of often severe clinical phenotypes manifesting in early childhood. Here, we report on three complex-I-deficient adult subjects with relatively mild clinical symptoms, including isolated, progressive exercise-induced myalgia and exercise intolerance but with normal later development. Exome sequencing and targeted exome sequencing revealed compound-heterozygous mutations in TMEM126B, encoding a complex I assembly factor. Further biochemical analysis of subject fibroblasts revealed a severe complex I deficiency caused by defective assembly...
July 7, 2016: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27346135/prognostic-value-of-lymph-node-metastases-detected-during-surgical-exploration-for-pancreatic-or-periampullary-cancer-a-systematic-review-and-meta-analysis
#9
REVIEW
Lennart B van Rijssen, Poorvi Narwade, Nadine C M van Huijgevoort, Dorine S J Tseng, Hjalmar C van Santvoort, Isaac Q Molenaar, Hanneke W M van Laarhoven, Casper H J van Eijck, Olivier R C Busch, Marc G H Besselink
BACKGROUND: Hepatic-artery and para-aortic lymph node metastases (LNM) may be detected during surgical exploration for pancreatic (PDAC) or periampullary cancer. Some surgeons will continue the resection while others abort the exploration. METHODS: A systematic search was performed in PubMed, EMBASE and Cochrane Library for studies investigating survival in patients with intra-operatively detected hepatic-artery or para-aortic LNM. Survival was stratified for node positive (N1) disease...
July 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/27279782/low-radio-frequency-eclipses-of-the-redback-pulsar-j2215-5135-observed-in-the-image-plane-with-lofar
#10
J W Broderick, R P Fender, R P Breton, A J Stewart, A Rowlinson, J D Swinbank, J W T Hessels, T D Staley, A J van der Horst, M E Bell, D Carbone, Y Cendes, S Corbel, J Eislöffel, H Falcke, J-M Grießmeier, T E Hassall, P Jonker, M Kramer, M Kuniyoshi, C J Law, S Markoff, G J Molenaar, M Pietka, L H A Scheers, M Serylak, B W Stappers, S Ter Veen, J van Leeuwen, R A M J Wijers, R Wijnands, M W Wise, P Zarka
The eclipses of certain types of binary millisecond pulsars (i.e. 'black widows' and 'redbacks') are often studied using high-time-resolution, 'beamformed' radio observations. However, they may also be detected in images generated from interferometric data. As part of a larger imaging project to characterize the variable and transient sky at radio frequencies <200 MHz, we have blindly detected the redback system PSR J2215+5135 as a variable source of interest with the Low-Frequency Array (LOFAR). Using observations with cadences of two weeks - six months, we find preliminary evidence that the eclipse duration is frequency dependent (∝ν(-0...
July 1, 2016: Monthly Notices of the Royal Astronomical Society
https://www.readbyqxmd.com/read/27272012/electromagnetic-guided-bedside-placement-of-nasoenteral-feeding-tubes-by-nurses-is-non-inferior-to-endoscopic-placement-by-gastroenterologists-a-multicenter-randomized-controlled-trial
#11
Arja Gerritsen, Thijs de Rooij, Marcel G Dijkgraaf, Olivier R Busch, Jacques J Bergman, Dirk T Ubbink, Peter van Duijvendijk, G Willemien Erkelens, Mariël Klos, Philip M Kruyt, Dirk Jan Bac, Camiel Rosman, Adriaan C Tan, I Quintus Molenaar, Jan F Monkelbaan, Elisabeth M Mathus-Vliegent, Marc G Besselink
OBJECTIVES: Electromagnetic (EM)-guided bedside placement of nasoenteral feeding tubes by nurses may improve efficiency and reduce patient discomfort and costs compared with endoscopic placement by gastroenterologists. However, evidence supporting this task shift from gastroenterologists to nurses is limited. We aimed to compare the effectiveness of EM-guided and endoscopic nasoenteral feeding tube placement. METHODS: We performed a multicenter randomized controlled non-inferiority trial in 154 adult patients who required nasoenteral feeding and were admitted to gastrointestinal surgical wards in five Dutch hospitals...
August 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27263513/robot-assisted-spleen-preserving-pancreatic-surgery-in-men1-patients
#12
Sjoerd Nell, Laurent Brunaud, Ahmet Ayav, Bert A Bonsing, Bas Groot Koerkamp, Els J Nieveen van Dijkum, Geert Kazemier, Ruben H J de Kleine, Jeroen Hagendoorn, I Quintus Molenaar, Gerlof D Valk, Inne H M Borel Rinkes, Menno R Vriens
BACKGROUND: Multiple Endocrine Neoplasia type 1 (MEN1) patients often undergo multiple pancreatic operations at a young age. OBJECTIVE: To describe robot-assisted and laparoscopic spleen-preserving pancreatic surgery in MEN1 patients, and to compare both techniques. METHODS: Robot-assisted pancreatectomies of the DutchMEN1 study group and the Université de Lorraine, Nancy, France were compared to a historical cohort of laparoscopic treated MEN1 patients...
September 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27146085/ultrasonography-to-investigate-the-effect-of-supplementing-whole-milk-with-complex-carbohydrates-and-specific-amino-acids-on-curd-retention-in-the-abomasum-of-dairy-calves
#13
K Singh, S R Leath, H V Henderson, A J Molenaar, T J Watson, D Pacheco, C D McMahon
AIM: To determine whether the retention time of curd in the abomasum of calves was influenced by supplementing milk with a plant-derived carbohydrate and amino acid supplement, evaluated non-invasively using ultrasonography. METHODS: Female dairy calves aged between 2-6 days of age were sourced from a commercial farm in March 2013. All calves were fed whole milk until weaning (4 L per day); 21 calves were supplemented with a probiotic until 18 days of age, and thereafter with a plant-derived complex carbohydrate and amino acid supplement until weaning, and 22 calves were just fed whole milk...
September 2016: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/27133661/characterization-of-sarcoplasmic-reticulum-ca-2-atpase-pumps-in-muscle-of-patients-with-myotonic-dystrophy-and-with-hypothyroid-myopathy
#14
V Guglielmi, A Oosterhof, N C Voermans, R Cardani, J P Molenaar, T H van Kuppevelt, G Meola, B G van Engelen, G Tomelleri, G Vattemi
Sarcoplasmic/endoplasmic reticulum Ca(2+) ATPase (SERCA) pumps play the major role in lowering cytoplasmic calcium concentration in skeletal muscle by catalyzing the ATP-dependent transport of Ca(2+) from the cytosol to the lumen of the sarcoplasmic reticulum (SR). Although SERCA abnormalities have been hypothesized to contribute to the dysregulation of intracellular Ca(2+) homeostasis and signaling in muscle of patients with myotonic dystrophy (DM) and hypothyroid myopathy, the characterization of SERCA pumps remains elusive and their impairment is still unclear...
June 2016: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/27122070/-overactive-muscles-it-can-be-more-serious-than-common-myalgia-or-cramp
#15
Joery P F Molenaar, Marc M J Snoeck, Nicol C Voermans, Baziel G M van Engelen
Positive muscle phenomena are due to muscle overactivity. Examples are cramp, myalgia, and stiffness. These manifestations have mostly acquired causes, e.g. side-effects of medication, metabolic disorders, vitamin deficiency, excessive caffeine intake or neurogenic disorders. We report on three patients with various positive muscle phenomena, to illustrate the clinical signs that indicate an underlying myopathy. Patient A, a 56-year-old man, was diagnosed with muscle cramp in the context of excessive coffee use and previous lumbosacral radiculopathy...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27107961/molecular-assessment-of-bacterial-vaginosis-by-lactobacillus-abundance-and-species-diversity
#16
Joke A M Dols, Douwe Molenaar, Jannie J van der Helm, Martien P M Caspers, Alie de Kat Angelino-Bart, Frank H J Schuren, Adrianus G C L Speksnijder, Hans V Westerhoff, Jan Hendrik Richardus, Mathilde E Boon, Gregor Reid, Henry J C de Vries, Remco Kort
BACKGROUND: To date, women are most often diagnosed with bacterial vaginosis (BV) using microscopy based Nugent scoring or Amsel criteria. However, the accuracy is less than optimal. The aim of the present study was to confirm the identity of known BV-associated composition profiles and evaluate indicators for BV using three molecular methods. METHODS: Evaluation of indicators for BV was carried out by 16S rRNA amplicon sequencing of the V5-V7 region, a tailor-made 16S rRNA oligonucleotide-based microarray, and a PCR-based profiling technique termed IS-profiling, which is based on fragment variability of the 16S-23S rRNA intergenic spacer region...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27089068/long-term-outcomes-of-patients-with-recent-onset-rheumatoid-arthritis-after-10-years-of-tight-controlled-treatment-a-randomized-trial
#17
RANDOMIZED CONTROLLED TRIAL
Iris M Markusse, Gülsah Akdemir, Linda Dirven, Yvonne P M Goekoop-Ruiterman, Johannes H L M van Groenendael, K Huub Han, T H Esmeralda Molenaar, Saskia Le Cessie, Willem F Lems, Peter A H M van der Lubbe, Pit J S M Kerstens, André J Peeters, H Karel Ronday, Peter B J de Sonnaville, Irene Speyer, Theo Stijnen, Saskia Ten Wolde, Tom W J Huizinga, Cornelia F Allaart
BACKGROUND: Treat-to-target therapy is effective for patients with rheumatoid arthritis (RA), but long-term results of continued targeted treatment are lacking. OBJECTIVE: To evaluate long-term outcomes in patients with early RA after 10 years of targeted treatment in 4 treatment strategies. DESIGN: Randomized trial. (Nederlands Trial Register: NTR262 and NTR265). SETTING: The Netherlands. PATIENTS: 508 patients with early active RA...
April 19, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27059639/pancreatoduodenectomy-with-colon-resection-for-cancer-a-nationwide-retrospective-analysis
#18
E Madelief Marsman, Thijs de Rooij, Casper H van Eijck, Djamila Boerma, Bert A Bonsing, Ronald M van Dam, Susan van Dieren, Joris I Erdmann, Michael F Gerhards, Ignace H de Hingh, Geert Kazemier, Joost Klaase, I Quintus Molenaar, Gijs A Patijn, Joris J Scheepers, Pieter J Tanis, Olivier R Busch, Marc G Besselink
BACKGROUND: Microscopically radical (R0) resection of pancreatic, periampullary, or colon cancer may occasionally require a pancreatoduodenectomy with colon resection (PD-colon), but the benefits of this procedure have been disputed, and multicenter studies on morbidity and oncologic outcomes after PD-colon are lacking. This study aimed to assess complications and survival after PD-colon. METHODS: Patients who had undergone PD-colon from 2004-2014 in 1 of 13 centers were analyzed retrospectively...
July 2016: Surgery
https://www.readbyqxmd.com/read/27037200/volume-outcome-relationships-in-pancreatoduodenectomy-for-cancer
#19
Lydia G M van der Geest, L Bengt van Rijssen, I Quintus Molenaar, Ignace H de Hingh, Bas Groot Koerkamp, Olivier R C Busch, Valery E P P Lemmens, Marc G H Besselink
BACKGROUND: Volume-outcome relationships in pancreatic surgery are well established, but an optimal volume remains to be determined. Studies analyzing outcomes in volume categories exceeding 20 procedures annually are lacking. STUDY DESIGN: A consecutive 3420 patients underwent PD for primary pancreatic or periampullary carcinoma (2005-2013) and were registered in the Netherlands Cancer Registry. Relationships between hospital volume (< 5, 5-19, 20-39 and ≥ 40 PDs/year) and mortality and survival were explored...
April 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/26993629/stop-or-go-preventive-cognitive-therapy-with-guided-tapering-of-antidepressants-during-pregnancy-study-protocol-of-a-pragmatic-multicentre-non-inferiority-randomized-controlled-trial
#20
Nina M Molenaar, Marlies E Brouwer, Claudi L H Bockting, Gouke J Bonsel, Christine N van der Veere, Hanneke W Torij, Witte J G Hoogendijk, Johannes J Duvekot, Huibert Burger, Mijke P Lambregtse-van den Berg
BACKGROUND: Approximately 6.2 % of women in the USA and 3.7 % of women in the UK, use Selective Serotonin Reuptake Inhibitors (SSRIs) during their pregnancies because of depression and/or anxiety. In the Netherlands, this prevalence is around 2 %. Nonetheless, SSRI use during pregnancy is still controversial. On the one hand SSRIs may be toxic to the intrauterine developing child, while on the other hand relapse or recurrence of depression during pregnancy poses risks for both mother and child...
2016: BMC Psychiatry
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