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https://www.readbyqxmd.com/read/28317583/the-diagnostic-performance-of-18-f-fdg-pet-ct-ct-and-mri-in-the-treatment-evaluation-of-ablation-therapy-for-colorectal-liver-metastases-a-systematic-review-and-meta-analysis
#1
REVIEW
M Samim, I Q Molenaar, M F J Seesing, P S N van Rossum, M A A J van den Bosch, T J M Ruers, I H M Borel Rinkes, R van Hillegersberg, M G E H Lam, H M Verkooijen
PURPOSE: Uncertainty exists regarding the optimal imaging modality for timely detection of disease progression (DP) after ablation therapy for colorectal liver metastases. We evaluated the diagnostic accuracy of (18)F-FDG PET(/CT), CT and MRI for detection of DP following ablation therapy. METHODS: A systematic search was performed on May 18, 2016. The analysis included studies that reported on the diagnostic accuracy of (18)F-FDG PET(/CT), CT and/or MRI for post-ablative evaluation of patients with liver metastases...
March 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28243453/selection-for-production-related-traits-in-pelargonium-zonale-improved-design-and-analysis-make-all-the-difference
#2
Heike Molenaar, Martin Glawe, Robert Boehm, Hans-Peter Piepho
Ornamental plant variety improvement is limited by current phenotyping approaches and neglected use of experimental designs. The present study was conducted to show the benefits of using an experimental design and corresponding analysis in ornamental breeding regarding simulated response to selection in Pelargonium zonale for production-related traits. This required establishment of phenotyping protocols for root formation and stem cutting counts, with which 974 genotypes were assessed in a two-phase experimental design...
2017: Horticulture Research
https://www.readbyqxmd.com/read/28241220/management-of-severe-pancreatic-fistula-after-pancreatoduodenectomy
#3
F Jasmijn Smits, Hjalmar C van Santvoort, Marc G Besselink, Marilot C T Batenburg, Robbert A E Slooff, Djamila Boerma, Olivier R Busch, Peter P L O Coene, Ronald M van Dam, David P J van Dijk, Casper H J van Eijck, Sebastiaan Festen, Erwin van der Harst, Ignace H J T de Hingh, Koert P de Jong, Johanna A M G Tol, Inne H M Borel Rinkes, I Quintus Molenaar
Importance: Postoperative pancreatic fistula is a potentially life-threatening complication after pancreatoduodenectomy. Evidence for best management is lacking. Objective: To evaluate the clinical outcome of patients undergoing catheter drainage compared with relaparotomy as primary treatment for pancreatic fistula after pancreatoduodenectomy. Design, Setting, and Participants: A multicenter, retrospective, propensity-matched cohort study was conducted in 9 centers of the Dutch Pancreatic Cancer Group from January 1, 2005, to September 30, 2013...
February 22, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28205119/use-of-three-dimensional-computed-tomography-overlay-for-real-time-cryoballoon-ablation-in-atrial-fibrillation-reduces-radiation-dose-and-contrast-dye
#4
B Oude Velthuis, M Molenaar, H G Reinhart Dorman, J Y Stevenhagen, M F Scholten, J van der Palen, J M van Opstal
AIMS: Cryoballoon pulmonary vein (PV) isolation in patients with atrial fibrillation has proven to be effective in short-term and long-term follow-up. To visualise the PV anatomy, pre-ablation contrast pulmonary venography is commonly performed. Three-dimensional (3D) computed tomography (CT) overlay is a new technique creating a live 3D image of the left atrium by integrating a previously obtained CT scan during fluoroscopy. To evaluate the benefits of 3D CT overlay during cryoballoon ablation, we studied the use of 3D CT overlay versus contrast pulmonary venography in a randomised fashion in patients with paroxysmal atrial fibrillation undergoing cryoballoon PV isolation...
February 15, 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/28131631/ryanodine-receptor-modification-and-regulation-by-intracellular-ca-2-and-mg-2-in-healthy-and-failing-human-hearts
#5
K Walweel, P Molenaar, M S Imtiaz, A Denniss, C Dos Remedios, D F van Helden, A F Dulhunty, D R Laver, N A Beard
RATIONALE: Heart failure is a multimodal disorder, of which disrupted Ca(2+) homeostasis is a hallmark. Central to Ca(2+) homeostasis is the major cardiac Ca(2+) release channel - the ryanodine receptor (RyR2) - whose activity is influenced by associated proteins, covalent modification and by Ca(2+) and Mg(2+). That RyR2 is remodelled and its function disturbed in heart failure is well recognized, but poorly understood. OBJECTIVE: To assess Ca(2+) and Mg(2+) regulation of RyR2 from left ventricles of healthy, cystic fibrosis and failing hearts, and to correlate these functional changes with RyR2 modifications and remodelling...
March 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28065427/systematic-review-on-the-treatment-of-isolated-local-recurrence-of-pancreatic-cancer-after-surgery-re-resection-chemoradiotherapy-and-sbrt
#6
REVIEW
Vincent P Groot, Hjalmar C van Santvoort, Steffi J E Rombouts, Jeroen Hagendoorn, Inne H M Borel Rinkes, Marco van Vulpen, Joseph M Herman, Christopher L Wolfgang, Marc G Besselink, I Quintus Molenaar
BACKGROUND: The majority of patients who have undergone a pancreatic resection for pancreatic cancer develop disease recurrence within two years. In around 30% of these patients, isolated local recurrence (ILR) is found. The aim of this study was to systematically review treatment options for this subgroup of patients. METHODS: A systematic search was performed in PubMed, Embase and the Cochrane Library. Studies reporting on the treatment of ILR after initial curative-intent resection of primary pancreatic cancer were included...
January 3, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28052102/irreversible-electroporation-of-the-pancreas-using-parallel-plate-electrodes-in-a-porcine-model-a-feasibility-study
#7
Steffi J E Rombouts, Maarten W Nijkamp, Willemijn P M van Dijck, Lodewijk A A Brosens, Maurits Konings, R van Hillegersberg, Inne H M Borel Rinkes, Jeroen Hagendoorn, Fred H Wittkampf, I Quintus Molenaar
BACKGROUND: Irreversible electroporation (IRE) with needle electrodes is being explored as treatment option in locally advanced pancreatic cancer. Several studies have shown promising results with IRE needles, positioned around the tumor to achieve tumor ablation. Disadvantages are the technical difficulties for needle placement, the time needed to achieve tumor ablation, the risk of needle track seeding and most important the possible occurrence of postoperative pancreatic fistula via the needle tracks...
2017: PloS One
https://www.readbyqxmd.com/read/27920244/are-the-registry-data-reliable-an-audit-of-a-regional-trauma-registry-in-the-netherlands
#8
E E Horton, P Krijnen, H M Molenaar, I B Schipper
OBJECTIVE: Data in trauma registries need to be reliable when used for evaluation of injury management, trauma protocols and hospital statistics. The aim of this audit was to analyse the reliability of the data in the Trauma Centre West Netherlands (TCWN) region. DESIGN: Routinely registered trauma patients from all nine hospitals in the TCWN region were re-registered by a registrar for analysis. SETTING: Nine hospitals in the TCWN region in the Netherlands...
December 4, 2016: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/27847657/rare-case-of-an-epithelial-cyst-in-an-intrapancreatic-accessory-spleen-treated-by-robot-assisted-spleen-preserving-distal-pancreatectomy
#9
Willemijn P M van Dijck, Vincent P Groot, Lodewijk A A Brosens, Jeroen Hagendoorn, Inne H M Borel Rinkes, Maarten S van Leeuwen, I Quintus Molenaar
Epithelial cyst in an intrapancreatic accessory spleen (ECIPAS) is exceedingly rare with only 57 cases reported since the first publication in 1980. Comprehensive clinical and diagnostic features remain to be clarified. We present a case of ECIPAS in a 21-year-old Philippine woman who was admitted with right upper quadrant abdominal pain. A cystic lesion in the pancreatic tail was discovered and evaluated by computed tomography and magnetic resonance images. Based on clinical and radiological features a solid pseudopapillary neoplasm was suspected...
2016: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/27741008/impact-of-a-nationwide-training-program-in-minimally-invasive-distal-pancreatectomy-laelaps
#10
Thijs de Rooij, Jony van Hilst, Djamila Boerma, Bert A Bonsing, Freek Daams, Ronald M van Dam, Marcel G Dijkgraaf, Casper H van Eijck, Sebastiaan Festen, Michael F Gerhards, Bas Groot Koerkamp, Erwin van der Harst, Ignace H de Hingh, Geert Kazemier, Joost Klaase, Ruben H de Kleine, Cornelis J van Laarhoven, Daan J Lips, Misha D Luyer, I Quintus Molenaar, Gijs A Patijn, Daphne Roos, Joris J Scheepers, George P van der Schelling, Pascal Steenvoorde, Menno R Vriens, Jan H Wijsman, Dirk J Gouma, Olivier R Busch, Mohammed Abu Hilal, Marc G Besselink
OBJECTIVE: To study the feasibility and impact of a nationwide training program in minimally invasive distal pancreatectomy (MIDP). SUMMARY OF BACKGROUND DATA: Superior outcomes of MIDP compared with open distal pancreatectomy have been reported. In the Netherlands (2005 to 2013) only 10% of distal pancreatectomies were in a minimally invasive fashion and 85% of surgeons welcomed MIDP training. The feasibility and impact of a nationwide training program is unknown...
November 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27699793/genetic-architecture-of-plant-stress-resistance-multi-trait-genome-wide-association-mapping
#11
Manus P M Thoen, Nelson H Davila Olivas, Karen J Kloth, Silvia Coolen, Ping-Ping Huang, Mark G M Aarts, Johanna A Bac-Molenaar, Jaap Bakker, Harro J Bouwmeester, Colette Broekgaarden, Johan Bucher, Jacqueline Busscher-Lange, Xi Cheng, Emilie F Fradin, Maarten A Jongsma, Magdalena M Julkowska, Joost J B Keurentjes, Wilco Ligterink, Corné M J Pieterse, Carolien Ruyter-Spira, Geert Smant, Christa Testerink, Björn Usadel, Joop J A van Loon, Johan A van Pelt, Casper C van Schaik, Saskia C M van Wees, Richard G F Visser, Roeland Voorrips, Ben Vosman, Dick Vreugdenhil, Sonja Warmerdam, Gerrie L Wiegers, Joost van Heerwaarden, Willem Kruijer, Fred A van Eeuwijk, Marcel Dicke
Plants are exposed to combinations of various biotic and abiotic stresses, but stress responses are usually investigated for single stresses only. Here, we investigated the genetic architecture underlying plant responses to 11 single stresses and several of their combinations by phenotyping 350 Arabidopsis thaliana accessions. A set of 214 000 single nucleotide polymorphisms (SNPs) was screened for marker-trait associations in genome-wide association (GWA) analyses using tailored multi-trait mixed models. Stress responses that share phytohormonal signaling pathways also share genetic architecture underlying these responses...
February 2017: New Phytologist
https://www.readbyqxmd.com/read/27460417/identification-of-a-novel-inactivating-mutation-in-isocitrate-dehydrogenase-1-idh1-r314c-in-a-high-grade-astrocytoma
#12
Sanne A M van Lith, Anna C Navis, Krissie Lenting, Kiek Verrijp, Jan T G Schepens, Wiljan J A J Hendriks, Nil A Schubert, Hanka Venselaar, Ron A Wevers, Arno van Rooij, Pieter Wesseling, Remco J Molenaar, Cornelis J F van Noorden, Stefan Pusch, Bastiaan Tops, William P J Leenders
The majority of low-grade and secondary high-grade gliomas carry heterozygous hotspot mutations in cytosolic isocitrate dehydrogenase 1 (IDH1) or the mitochondrial variant IDH2. These mutations mostly involve Arg132 in IDH1, and Arg172 or Arg140 in IDH2. Whereas IDHs convert isocitrate to alpha-ketoglutarate (α-KG) with simultaneous reduction of NADP(+) to NADPH, these IDH mutants reduce α-KG to D-2-hydroxyglutarate (D-2-HG) while oxidizing NADPH. D-2-HG is a proposed oncometabolite, acting via competitive inhibition of α-KG-dependent enzymes that are involved in metabolism and epigenetic regulation...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27429027/impact-of-a-nationwide-training-program-in-minimally-invasive-distal-pancreatectomy-laelaps
#13
Thijs de Rooij, Jony van Hilst, Djamila Boerma, Bert A Bonsing, Freek Daams, Ronald M van Dam, Marcel G Dijkgraaf, Casper H van Eijck, Sebastiaan Festen, Michael F Gerhards, Bas Groot Koerkamp, Erwin van der Harst, Ignace H de Hingh, Geert Kazemier, Joost Klaase, Ruben H de Kleine, Cornelis J van Laarhoven, Daan J Lips, Misha D Luyer, I Quintus Molenaar, Gijs A Patijn, Daphne Roos, Joris J Scheepers, George P van der Schelling, Pascal Steenvoorde, Menno R Vriens, Jan H Wijsman, Dirk J Gouma, Olivier R Busch, Mohammed Abu Hilal, Marc G Besselink
OBJECTIVE: To study the feasibility and impact of a nationwide training program in minimally invasive distal pancreatectomy (MIDP). SUMMARY OF BACKGROUND DATA: Superior outcomes of MIDP compared with open distal pancreatectomy have been reported. In the Netherlands (2005 to 2013) only 10% of distal pancreatectomies were in a minimally invasive fashion and 85% of surgeons welcomed MIDP training. The feasibility and impact of a nationwide training program is unknown...
August 1, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27403336/does-body-mass-index-bmi-influence-the-ankylosing-spondylitis-disease-activity-score-in-axial-spondyloarthritis-data-from-the-space-cohort
#14
Roxana Rubio Vargas, Rosaline van den Berg, Miranda van Lunteren, Zineb Ez-Zaitouni, Pauline A C Bakker, Hanne Dagfinrud, Roberta Ramonda, Robert Landewé, Esmeralda Molenaar, Floris A van Gaalen, Désirée van der Heijde
OBJECTIVE: Obesity is associated with elevated C reactive protein (CRP) levels. The Ankylosing Spondylitis Disease Activity Score (ASDAS) combines patient-reported outcomes (PROs) and CRP. We evaluated the effect of body mass index (BMI) on CRP and on ASDAS, and studied if ASDAS can be used in obese axial spondyloarthritis (axSpA) patients to assess disease activity. METHODS: Baseline data of patients with chronic back pain of short duration included in the SPondyloArthritis Caught Early (SPACE) cohort were used...
2016: RMD Open
https://www.readbyqxmd.com/read/27374773/mutations-in-complex-i-assembly-factor-tmem126b-result-in-muscle-weakness-and-isolated-complex-i-deficiency
#15
Laura Sánchez-Caballero, Benedetta Ruzzenente, Lucas Bianchi, Zahra Assouline, Giulia Barcia, Metodi D Metodiev, Marlène Rio, Benoît Funalot, Mariël A M van den Brand, Sergio Guerrero-Castillo, Joery P Molenaar, David Koolen, Ulrich Brandt, Richard J Rodenburg, Leo G Nijtmans, Agnès Rötig
Mitochondrial complex I deficiency results in a plethora of often severe clinical phenotypes manifesting in early childhood. Here, we report on three complex-I-deficient adult subjects with relatively mild clinical symptoms, including isolated, progressive exercise-induced myalgia and exercise intolerance but with normal later development. Exome sequencing and targeted exome sequencing revealed compound-heterozygous mutations in TMEM126B, encoding a complex I assembly factor. Further biochemical analysis of subject fibroblasts revealed a severe complex I deficiency caused by defective assembly...
July 7, 2016: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27346135/prognostic-value-of-lymph-node-metastases-detected-during-surgical-exploration-for-pancreatic-or-periampullary-cancer-a-systematic-review-and-meta-analysis
#16
REVIEW
Lennart B van Rijssen, Poorvi Narwade, Nadine C M van Huijgevoort, Dorine S J Tseng, Hjalmar C van Santvoort, Isaac Q Molenaar, Hanneke W M van Laarhoven, Casper H J van Eijck, Olivier R C Busch, Marc G H Besselink
BACKGROUND: Hepatic-artery and para-aortic lymph node metastases (LNM) may be detected during surgical exploration for pancreatic (PDAC) or periampullary cancer. Some surgeons will continue the resection while others abort the exploration. METHODS: A systematic search was performed in PubMed, EMBASE and Cochrane Library for studies investigating survival in patients with intra-operatively detected hepatic-artery or para-aortic LNM. Survival was stratified for node positive (N1) disease...
July 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/27279782/low-radio-frequency-eclipses-of-the-redback-pulsar-j2215-5135-observed-in-the-image-plane-with-lofar
#17
J W Broderick, R P Fender, R P Breton, A J Stewart, A Rowlinson, J D Swinbank, J W T Hessels, T D Staley, A J van der Horst, M E Bell, D Carbone, Y Cendes, S Corbel, J Eislöffel, H Falcke, J-M Grießmeier, T E Hassall, P Jonker, M Kramer, M Kuniyoshi, C J Law, S Markoff, G J Molenaar, M Pietka, L H A Scheers, M Serylak, B W Stappers, S Ter Veen, J van Leeuwen, R A M J Wijers, R Wijnands, M W Wise, P Zarka
The eclipses of certain types of binary millisecond pulsars (i.e. 'black widows' and 'redbacks') are often studied using high-time-resolution, 'beamformed' radio observations. However, they may also be detected in images generated from interferometric data. As part of a larger imaging project to characterize the variable and transient sky at radio frequencies <200 MHz, we have blindly detected the redback system PSR J2215+5135 as a variable source of interest with the Low-Frequency Array (LOFAR). Using observations with cadences of two weeks - six months, we find preliminary evidence that the eclipse duration is frequency dependent (∝ν(-0...
July 1, 2016: Monthly Notices of the Royal Astronomical Society
https://www.readbyqxmd.com/read/27272012/electromagnetic-guided-bedside-placement-of-nasoenteral-feeding-tubes-by-nurses-is-non-inferior-to-endoscopic-placement-by-gastroenterologists-a-multicenter-randomized-controlled-trial
#18
Arja Gerritsen, Thijs de Rooij, Marcel G Dijkgraaf, Olivier R Busch, Jacques J Bergman, Dirk T Ubbink, Peter van Duijvendijk, G Willemien Erkelens, Mariël Klos, Philip M Kruyt, Dirk Jan Bac, Camiel Rosman, Adriaan C Tan, I Quintus Molenaar, Jan F Monkelbaan, Elisabeth M Mathus-Vliegent, Marc G Besselink
OBJECTIVES: Electromagnetic (EM)-guided bedside placement of nasoenteral feeding tubes by nurses may improve efficiency and reduce patient discomfort and costs compared with endoscopic placement by gastroenterologists. However, evidence supporting this task shift from gastroenterologists to nurses is limited. We aimed to compare the effectiveness of EM-guided and endoscopic nasoenteral feeding tube placement. METHODS: We performed a multicenter randomized controlled non-inferiority trial in 154 adult patients who required nasoenteral feeding and were admitted to gastrointestinal surgical wards in five Dutch hospitals...
August 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27263513/robot-assisted-spleen-preserving-pancreatic-surgery-in-men1-patients
#19
Sjoerd Nell, Laurent Brunaud, Ahmet Ayav, Bert A Bonsing, Bas Groot Koerkamp, Els J Nieveen van Dijkum, Geert Kazemier, Ruben H J de Kleine, Jeroen Hagendoorn, I Quintus Molenaar, Gerlof D Valk, Inne H M Borel Rinkes, Menno R Vriens
BACKGROUND: Multiple Endocrine Neoplasia type 1 (MEN1) patients often undergo multiple pancreatic operations at a young age. OBJECTIVE: To describe robot-assisted and laparoscopic spleen-preserving pancreatic surgery in MEN1 patients, and to compare both techniques. METHODS: Robot-assisted pancreatectomies of the DutchMEN1 study group and the Université de Lorraine, Nancy, France were compared to a historical cohort of laparoscopic treated MEN1 patients...
September 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27146085/ultrasonography-to-investigate-the-effect-of-supplementing-whole-milk-with-complex-carbohydrates-and-specific-amino-acids-on-curd-retention-in-the-abomasum-of-dairy-calves
#20
K Singh, S R Leath, H V Henderson, A J Molenaar, T J Watson, D Pacheco, C D McMahon
AIM: To determine whether the retention time of curd in the abomasum of calves was influenced by supplementing milk with a plant-derived carbohydrate and amino acid supplement, evaluated non-invasively using ultrasonography. METHODS: Female dairy calves aged between 2-6 days of age were sourced from a commercial farm in March 2013. All calves were fed whole milk until weaning (4 L per day); 21 calves were supplemented with a probiotic until 18 days of age, and thereafter with a plant-derived complex carbohydrate and amino acid supplement until weaning, and 22 calves were just fed whole milk...
September 2016: New Zealand Veterinary Journal
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