keyword
MENU ▼
Read by QxMD icon Read
search

Cynomolgus

keyword
https://www.readbyqxmd.com/read/29352039/disrupting-cd147-rap2-interaction-abrogates-erythrocyte-invasion-by-plasmodium-falciparum
#1
Meng-Yao Zhang, Yang Zhang, Xiao-Dong Wu, Kun Zhang, Peng Lin, Hui-Jie Bian, Min-Min Qin, Wan Huang, Ding Wei, Zhao Zhang, Jiao Wu, Ruo Chen, Fei Feng, Bin Wang, Gang Nan, Ping Zhu, Zhi-Nan Chen
Effective vaccines against Plasmodium falciparum malaria are still lacking and the molecular mechanism of the host-parasite interaction is not fully understood. Here we demonstrate that the interaction of RAP2, a parasite secreted rhoptry protein functioning in the parasitophorous vacuole formation stage of the invasion, and CD147 on host erythrocyte is essential for erythrocyte invasion by Plasmodium falciparum and is independent from all previously identified interactions involved. Importantly, the blockade of the CD147-RAP2 interaction by HP6H8, a humanized CD147 antibody, completely abolished the parasite invasion with both cure and preventative functions in a humanized mouse model...
January 19, 2018: Blood
https://www.readbyqxmd.com/read/29339225/metabolism-and-pharmacokinetics-of-a-potent-n-acylindole-antagonist-of-the-oxe-receptor-for-the-eosinophil-chemoattractant-5-oxo-6-8-11-14-eicosatetraenoic-acid-5-oxo-ete-in-rats-and-monkeys
#2
Chintam Nagendra Reddy, Hussam Alhamza, Shishir Chourey, Qiuji Ye, Vivek Gore, Chantal Cossette, Sylvie Gravel, Irina Slobodchikova, Dajana Vuckovic, Joshua Rokach, William S Powell
We previously identified the indole 264 as a potent in vitro antagonist of the human OXE receptor that mediates the actions of the powerful eosinophil chemoattractant 5-oxo-ETE. No antagonists of this receptor are currently commercially available or are being tested in clinical studies. The lack of a rodent ortholog of the OXE receptor has hampered progress in this area because of the unavailability of commonly used mouse or rat animal models. In the present study, we examined the feasibility of using the cynomolgus monkey as an animal model to investigate the efficacy of orally administered 264 in future in vivo studies...
January 12, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29333420/technique-for-orthotopic-liver-transplantation-in-cynomolgus-monkeys-macaca-fascicularis
#3
Kyo Won Lee, Chan Woo Cho, Hyojun Park, Gyu-Seong Choi, Jae Berm Park, Sung Joo Kim
Purpose: Recent studies investigating new strategies to modulate the immune system have utilized animal models of liver transplantation (LT). However, the anhepatic phase (AHP) remains a crucial problem in LT. The aim of the present study is to introduce a technique for successful orthotopic LT in cynomolgus monkeys using an early-reperfusion strategy. Methods: Orthotopicallo-LT was performed with seven donor/recipient pairs of cynomolgus monkeys. Results: In 2 recipients, liver allografts were perfused after suprahepatic inferior vena cava (SHIVC), portal vein (PV), and infrahepatic inferior vena cava (IHIVC) anastomosis...
January 2018: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29329501/sustained-plasma-hepcidin-suppression-and-iron-elevation-by-anticalin-derived-hepcidin-antagonist-in-cynomolgus-monkey
#4
Andreas M Hohlbaum, Hendrik Gille, Stefan Trentmann, Maria Kolodziejczyk, Barbara Rattenstetter, Coby M Laarakkers, Galina Katzmann, Hans Jürgen Christian, Nicole Andersen, Andrea Allersdorfer, Shane A Olwill, Bernd Meibohm, Laurent P Audoly, Dorine W Swinkels, Rachel P L van Swelm
BACKGROUND AND PURPOSE: Anaemia of chronic disease (ACD) has been linked to iron restricted erythropoiesis imposed by high circulating levels of hepcidin, a 25 amino acid hepatocyte-derived peptide that controls systemic iron homeostasis. Here we report the engineering of the human lipocalin-derived, small protein-based Anticalin PRS-080 hepcidin antagonist with high affinity and selectivity. EXPERIMENTAL APPROACH: Anticalin- and hepcidin-specific pharmacokinetic/pharmacodynamic modelling was used to design and select the suitable drug candidate based on half life extension and duration of hepcidin suppression...
January 12, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29327727/generation-of-a-precise-oct4-hrgfp-knockin-cynomolgus-monkey-model-via-crispr-cas9-assisted-homologous-recombination
#5
Yiqiang Cui, Yuyu Niu, Jiankui Zhou, Yongchang Chen, Yiwei Cheng, Shangang Li, Zongyong Ai, Chu Chu, Hong Wang, Bo Zheng, Xuejin Chen, Jiahao Sha, Xuejiang Guo, Xingxu Huang, Weizhi Ji
No abstract text is available yet for this article.
January 12, 2018: Cell Research
https://www.readbyqxmd.com/read/29327726/generation-of-knock-in-cynomolgus-monkey-via-crispr-cas9-editing
#6
Xuan Yao, Zhen Liu, Xing Wang, Yan Wang, Yan-Hong Nie, Liang Lai, Ruilin Sun, Linyu Shi, Qiang Sun, Hui Yang
No abstract text is available yet for this article.
January 12, 2018: Cell Research
https://www.readbyqxmd.com/read/29325117/blood-rna-signatures-prospectively-discriminate-controllers-from-progressors-early-after-low-dose-m-tuberculosis-infection-of-cynomolgus-macaques
#7
Ethan G Thompson, Smitha Shankar, Hannah P Gideon, Jackie Braun, Joe Valvo, Jason Skinner, Alan Aderem, JoAnne L Flynn, Philana Ling Lin, Daniel E Zak
The cynomolgus macaque model of low-dose Mycobacterium tuberculosis (Mtb) infection recapitulates clinical aspects of human TB pathology but it is unknown whether the two systems are sufficiently similar that host-based signatures of TB will be predictive across species. By blind prediction, we demonstrate that a subset of genes comprising a human signature for TB risk is simultaneously predictive in humans and macaques and prospectively discriminates progressor from controller animals 3-6 weeks after infection...
January 8, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29320500/brain-structural-changes-in-cynomolgus-monkeys-administered-with-1-methyl-4-phenyl-1-2-3-6-tetrahydropyridine-a-longitudinal-voxel-based-morphometry-and-diffusion-tensor-imaging-study
#8
Hyeonseok S Jeong, Sang-Rae Lee, Jieun E Kim, In Kyoon Lyoo, Sujung Yoon, Eun Namgung, Kyu-Tae Chang, Bom Sahn Kim, Sejung Yang, Jooyeon J Im, Saerom Jeon, Ilhyang Kang, Jiyoung Ma, Yong-An Chung, Soo Mee Lim
In animal models of Parkinson's disease (PD), 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is one of the most widely used agents that damages the nigrostriatal dopaminergic pathway. However, brain structural changes in response to MPTP remain unclear. This study aimed to investigate in vivo longitudinal changes in gray matter (GM) volume and white matter (WM) microstructure in primate models administered with MPTP. In six cynomolgus monkeys, high-resolution magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) scans were acquired 7 times over 32 weeks, and assessments of motor symptoms were conducted over 15 months, before and after the MPTP injection...
2018: PloS One
https://www.readbyqxmd.com/read/29319621/selective-cd28-inhibition-modulates-alloimmunity-and-cardiac-allograft-vasculopathy-in-anti-cd154-treated-monkeys
#9
Tianshu Zhang, Agnes M Azimzadeh, Wenji Sun, Natalie A O'Neill, Evelyn Sievert, Emily Bergbower, Gheorghe Braileanu, Lars Burdorf, Xiangfei Cheng, Thomas Monahan, Siamak Dahi, Donald Harris, Elana Rybak, Emily Welty, Anthony Kronfli, Chris Avon, Richard N Pierson
BACKGROUND: Selective CD28 inhibition is actively pursued as an alternative to B7 blockade using CTLA4-Ig based on the hypothesis that the checkpoint immune regulators CTLA-4 and PD-L1 will induce tolerogenic immune signals. We previously showed that blocking CD28 using a monovalent nonactivating reagent (single chain anti-CD28 Fv fragment linked to alpha-1 anti-trypsin: sc28AT) synergizes with calcineurin inhibitors in nonhuman primate (NHP) kidney and heart transplantation. Here, we explored the efficacy of combining a 3-week 'induction" sc28AT treatment with prolonged CD154 blockade...
January 10, 2018: Transplantation
https://www.readbyqxmd.com/read/29311442/usefulness-of-simultaneous-and-sequential-monitoring-of-glucose-level-and-electrocardiogram-in-monkeys-treated-with-gatifloxacin-under-conscious-and-nonrestricted-conditions
#10
Yu Yoshimatsu, Tomomichi Ishizaka, Katsuyoshi Chiba, Kazuhiko Mori
Drug-induced cardiac electrophysiological abnormalities accompanied by hypoglycemia or hyperglycemia increase the risk for life-threatening arrhythmia. To assess the drug-induced cardiotoxic potential associated with extraordinary blood glucose (GLU) levels, the effect of gatifloxacin (GFLX) which was frequently associated with GLU abnormality and QT/QTc prolongations in the clinic on blood GLU and electrocardiogram (ECG) parameters was investigated in cynomolgus monkeys (n=4) given GFLX orally in an ascending dose regimen (10, 30, 60 and 100 mg/kg)...
January 3, 2018: Experimental Animals
https://www.readbyqxmd.com/read/29311111/dual-blockade-of-interleukin-1%C3%AE-and-interleukin-17a-reduces-murine-arthritis-pathogenesis-but-also-leads-to-spontaneous-skin-infections-in-non-human-primates
#11
Melanie C Ruzek, Lili Huang, Ting Ting Zhang, Shaughn Bryant, Peter F Slivka, Carolyn A Cuff, Catherine Tripp, Guenter Blaich
Despite the efficacy of biologics for treatment of rheumatoid arthritis (RA), many patients show inadequate responses and likely require neutralization of multiple mediators. Neutralization of both interleukin (IL)-1β and IL-17A with monoclonal antibodies showed greater efficacy than either agent alone in a mouse arthritis model with cooperative inhibition of key inflammatory factors, IL-6, granulocyte colony stimulating factor (G-CSF) and CXC chemokine ligand (CXCL)1. Given the potential clinical benefit in RA, we generated a human dual variable domain antibody (DVD-Ig), ABBV-615, capable of simultaneous binding and neutralization of IL-1β and IL-17A...
January 8, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29305572/proprioceptive-changes-in-bilateral-knee-joints-following-unilateral-anterior-cruciate-ligament-injury-in-cynomolgus-monkeys
#12
Lei Zhang, Ji Qi, Yan Zeng, Shaoqun Zhang, Shijie Fu, Xin Zhou, Ruiyue Ping, Yikai Li
BACKGROUND The anterior cruciate ligament (ACL) is one of the most important structures maintaining stability of knee joints, and the proprioception of the ACL plays a key role in it. If the ACL is injured in the unilateral knee joint, it changes nerve electrophysiology, morphology, and quantity of the proprioceptors in the bilateral ACL. The aim of this study was to explore the proprioceptive changes in the bilateral knee joints following unilateral ACL injury, and to provide a theoretical foundation and ideas for clinical treatment...
January 6, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29300231/long-term-nonhuman-primate-renal-allograft-survival-without-ongoing-immunosuppression-in-recipients-of-delayed-donor-bone-marrow-transplantation
#13
Kiyohiko Hotta, Tetsu Oura, Abbas Dehnadi, Svjetlan Boskovic, Masatoshi Matsunami, Ivy Rosales, Rex N Smith, Robert B Colvin, A Benedict Cosimi, Tatsuo Kawai
BACKGROUND: We have previously reported successful induction of renal allograft tolerance in nonhuman primates (NHP) following an initial posttransplant period of conventional immunosuppression (delayed tolerance) using a nonmyeloablative conditioning regimen consisting of anti-CD154 and anti-CD8 mAbs plus equine ATG (Atgam) and donor bone marrow transplantation (DBMT). Since these reagents are not currently clinically available, the protocol was revised to be applicable to human recipients of deceased donor allografts...
January 4, 2018: Transplantation
https://www.readbyqxmd.com/read/29299527/a-single-amino-acid-change-in-the-marburg-virus-glycoprotein-arises-during-serial-cell-culture-passages-and-attenuates-the-virus-in-a-macaque-model-of-disease
#14
Kendra J Alfson, Laura E Avena, Jenny Delgado, Michael W Beadles, Jean L Patterson, Ricardo Carrion, Anthony Griffiths
Marburg virus (MARV) causes disease with high case fatality rates, and there are no approved vaccines or therapies. Licensing of MARV countermeasures will likely require approval via the FDA's Animal Efficacy Rule, which requires well-characterized animal models that recapitulate human disease. This includes selection of the virus used for exposure and ensuring that it retains the properties of the original isolate. The consequences of amplification of MARV for challenge studies are unknown. Here, we serially passaged and characterized MARV through 13 passes from the original isolate...
January 2018: MSphere
https://www.readbyqxmd.com/read/29298756/adct-402-a-pbd-dimer-containing-antibody-drug-conjugate-targeting-cd19-expressing-malignancies
#15
Francesca Zammarchi, Simon Corbett, Lauren Adams, Peter C Tyrer, Konstantinos Kiakos, Narinder Janghra, Teresa Marafioti, Charles E Britten, Carin E G Havenith, Simon Chivers, Francois D'Hooge, David G Williams, Arnaud Tiberghien, Philip W Howard, John A Hartley, Patrick H van Berkel
Human CD19 antigen is a 95-kDa type I membrane glycoprotein in the immunoglobulin superfamily whose expression is limited to the various stages of B-cell development and differentiation and is maintained in the majority of B-cell malignancies, including leukemias and non-Hodgkin lymphomas of B-cell origin. Coupled with its differential and favourable expression profile, CD19 has rapid internalization kinetics and it is not shed into the circulation, making it an ideal target for the development of antibody-drug conjugates (ADCs) to treat B-cell malignancies...
January 3, 2018: Blood
https://www.readbyqxmd.com/read/29298302/characterization-of-a-candidate-tetravalent-vaccine-based-on-2-o-methyltransferase-mutants
#16
Roland Züst, Shi-Hua Li, Xuping Xie, Sumathy Velumani, Melissa Chng, Ying-Xiu Toh, Jing Zou, Hongping Dong, Chao Shan, Jassia Pang, Cheng-Feng Qin, Evan W Newell, Pei-Yong Shi, Katja Fink
Dengue virus (DENV) is one of the most widespread arboviruses. The four DENV serotypes infect about 400 million people every year, causing 96 million clinical dengue cases, of which approximately 500'000 are severe and potentially life-threatening. The only licensed vaccine has a limited efficacy and is only recommended in regions with high endemicity. We previously reported that 2'-O-methyltransferase mutations in DENV-1 and DENV-2 block their capacity to inhibit type I IFNs and render the viruses attenuated in vivo, making them amenable as vaccine strains; here we apply this strategy to all four DENV serotypes to generate a tetravalent, non-chimeric live-attenuated dengue vaccine...
2018: PloS One
https://www.readbyqxmd.com/read/29296907/tlr2-agonism-reverses-chemotherapy-induced-neutropenia-in-macaca-fascicularis
#17
Nicholas J Laping, Michael P DeMartino, Joshua E Cottom, Jeffrey M Axten, John G Emery, Jeffrey H Guss, Miriam Burman, James J Foley, Mui Cheung, Allen Oliff, Sanjay Kumar
Neutropenia is a common consequence of radiation and chemotherapy in cancer patients. The resulting immunocompromised patients become highly susceptible to potentially life-threatening infections. Granulocyte colony-stimulating factor (G-CSF) is known to stimulate neutrophil production and is widely used as a treatment of chemotherapy-induced neutropenia. A small-molecule G-CSF secretagogue without a requirement for refrigerated supply chain would offer a more convenient and cost-effective treatment of chemotherapy-induced neutropenia...
December 12, 2017: Blood Advances
https://www.readbyqxmd.com/read/29289670/a-novel-quantification-method-for-serine-hydrolases-in-cellular-expression-system-using-fluorophosphonate-biotin-probe
#18
Amira Abdel-Daim, Kayoko Ohura, Teruko Imai
In the present study, we established a quantitative western blotting method to measure the expression level of recombinant serine hydrolases based on their catalytic mechanism. Fluorophosphonate (FP) biotin was selected as a universal probe to quantify their expression level, since FP moiety irreversibly inhibits serine hydrolases through strong stoichiometric binding to active serine residue. The linearity of detection using FP-biotin was assessed on three serine hydrolases; human carboxylesterase (CES) 1, butyrylcholinesterase and porcine liver esterases (PLE)...
December 28, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29288556/rna-expression-profiling-of-non-human-primate-renal-allograft-rejection-identifies-tolerance
#19
R N Smith, M Matsunami, B A Adam, I A Rosales, T Oura, A B Cosimi, T Kawai, M Mengel, R B Colvin
Tolerance induction to prevent allograft rejection is a long standing clinical goal. However, convincing and dependable tolerance identification remains elusive. Hypothesizing that intragraft RNA expression is informative in both rejection and tolerance, we profile intra-renal allograft RNA expression in a mixed chimerism renal allograft model of Cynomolgus monkeys and identify biologically significant tolerance. Analysis of 67 genes identified three dominant factors, each with a different pattern of gene expressions, relating to T cell mediated rejection (TCMR), chronic antibody mediated rejection (CAMR), or Tolerance...
December 29, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29288079/17-18-epete-gpr40-axis-ameliorates-contact-hypersensitivity-by-inhibiting-neutrophil-mobility-in-mice-and-cynomolgus-macaques
#20
Takahiro Nagatake, Yumiko Shiogama, Asuka Inoue, Junichi Kikuta, Tetsuya Honda, Prabha Tiwari, Takayuki Kishi, Atsushi Yanagisawa, Yosuke Isobe, Naomi Matsumoto, Michiko Shimojou, Sakiko Morimoto, Hidehiko Suzuki, Soichiro Hirata, Pär Steneberg, Helena Edlund, Junken Aoki, Makoto Arita, Hiroshi Kiyono, Yasuhiro Yasutomi, Masaru Ishii, Kenji Kabashima, Jun Kunisawa
BACKGROUND: Metabolites of eicosapentaenoic acid (EPA) exert various physiological actions. 17,18-epoxyeicosatetraenoic acid (17,18-EpETE) is a recently identified new class of anti-allergic and anti-inflammatory lipid metabolite of EPA, but its effects on skin inflammation and the underlying mechanisms remain to be investigated. OBJECTIVE: We evaluated the effectiveness of 17,18-EpETE for the control of contact hypersensitivity in mouse and cynomolgus macaques...
December 26, 2017: Journal of Allergy and Clinical Immunology
keyword
keyword
75142
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"