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https://www.readbyqxmd.com/read/29674280/the-chemotherapeutic-effect-of-%C3%AE-2-himachalen-6-ol-in-chemically-induced-skin-tumorigenesis
#1
Hamid E Daaboul, Carole Dagher, Robin I Taleb, Kikki Bodman-Smith, Wassim N Shebaby, Mirvat El-Sibai, Mohamad A Mroueh, Costantine F Daher
β-2-himachalen-6-ol (HC), a novel sesquiterpene derived from Lebanese wild carrot, was shown to possess a remarkable anticancer activity. The present study investigates the in vitro anticancer activity of HC and its effect on papillomas induced using a DMBA/TPA skin carcinogenesis mouse model. HaCaT-ras II-4 epidermal squamous cell viability was assessed using WST-1 kit. Cell cycle was analyzed by flow cytometry, and pro/anti-apoptotic proteins were measured using western blot. Mice papillomas were induced by DMBA and promoted with TPA for 18 weeks...
April 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29671161/under-evaluated-or-unassessed-pathogenic-pathways-in-autoimmune-hepatitis-and-implications-for-future-management
#2
REVIEW
Albert J Czaja
Autoimmune hepatitis is a consequence of perturbations in homeostatic mechanisms that maintain self-tolerance but are incompletely understood. The goals of this review are to describe key pathogenic pathways that have been under-evaluated or unassessed in autoimmune hepatitis, describe insights that may shape future therapies, and encourage investigational efforts. The T cell immunoglobulin mucin proteins constitute a family that modulates immune tolerance by limiting the survival of immune effector cells, clearing apoptotic bodies, and expanding the population of granulocytic myeloid-derived suppressor cells...
April 18, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29669267/differential-effects-of-natural-curcumin-and-chemically-modified-curcumin-on-inflammation-and-bone-resorption-in-model-of-experimental-periodontitis
#3
Fabiana Almeida Curylofo-Zotti, Muna S Elburki, Priscilla Aparecida Oliveira, Paulo Sérgio Cerri, Leandro Alves Santos, Hsi-Ming Lee, Francis Johnson, Lorne M Golub, Carlos Rossa, Morgana Rodrigues Guimarães-Stabili
OBJECTIVE: The purpose of this study was to compare the effects of the oral administration of natural curcumin and a chemically modified curcumin (CMC2.24) on osteoclast-mediated bone resorption, apoptosis, and inflammation in a murine model of experimental periodontal disease. DESIGN: Fifty male rats were distributed among the following treatment groups: (i) 2% carboxymethylcellulose, (ii) CMC2.24 30 mg/kg body weight, (iii) Curcumin 100 mg/kg body weight and (iv) no treatment...
April 10, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29665555/hesperidin-promotes-programmed-cell-death-by-downregulation-of-nongenomic-estrogen-receptor-signalling-pathway-in-endometrial-cancer-cells
#4
Z B Cincin, B Kiran, Y Baran, B Cakmakoglu
Endometrial carcinoma (EC) is the most common malignant gynecologic tumor in women. EC is thought to be caused by increasing estrogen levels relative to progesterone in the body. Hesperidin (Hsd), a biologically active flavonoid, could be extracted from Citrus species. It has been recently shown that Hsd could exert anticarcinogenic properties in different cancer types. However, the effects of Hsd and its molecular mechanisms on EC remain unclear. In this study, the antiproliferative, apoptotic and genomic effects of Hsd in EC and its underlying mechanisms were identified...
April 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29663887/the-role-of-ire1-signaling-in-central-nervous-system-diseases
#5
Haibo Ni, Qin Rui, Di Li, Rong Gao, Gang Chen
The accumulation of misfolded or unfolded proteins in endoplasmic reticulum (ER) lumen results in activation of an adaptive stress process called the unfolded protein response (UPR). As the most conserved signaling branch of the UPR, Inositol-requiring enzyme 1 (IRE1) possesses both Ser/Thr kinase and RNase activities that operates as a major stress sensor, mediating both adaptive and pro-apoptotic pathways under ER stress. Over the last three decades, a mounting body of evidence has shown that IRE1 signaling dysfunction is involved in pathology of various neurological disorders...
April 15, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29663074/detection-of-pro-apoptotic-bax%C3%A2-2-proteins-in-the-human-cerebellum
#6
Adriana Mañas, Aislinn Davis, Sydney Lamerand, Jialing Xiang
Bax∆2 is a pro-apoptotic protein originally discovered in colon cancer patients with high microsatellite instability. Unlike most pro-apoptotic Bax family members, Bax∆2 mediates cell death through a non-mitochondrial caspase 8-dependent pathway. In the scope of analyzing the distribution of Bax∆2 expression in human tissues, we examined a panel of human brain samples. Here, we report four cerebellar cases in which the subjects had no neurological disorder or disease documented. We found Bax∆2 positive cells scattered in all areas of the cerebellum, but most strikingly concentrated in Purkinje cell bodies and dendrites...
April 17, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29663027/molecular-interactions-at-the-surface-of-extracellular-vesicles
#7
REVIEW
Edit I Buzás, Eszter Á Tóth, Barbara W Sódar, Katalin É Szabó-Taylor
Extracellular vesicles such as exosomes, microvesicles, apoptotic bodies, and large oncosomes have been shown to participate in a wide variety of biological processes and are currently under intense investigation in many different fields of biomedicine. One of the key features of extracellular vesicles is that they have relatively large surface compared to their volume. Some extracellular vesicle surface molecules are shared with those of the plasma membrane of the releasing cell, while other molecules are characteristic for extracellular vesicular surfaces...
April 16, 2018: Seminars in Immunopathology
https://www.readbyqxmd.com/read/29661988/the-effect-of-axon-resealing-on-retrograde-neuronal-death-after-spinal-cord-injury-in-lamprey
#8
Guixin Zhang, William Rodemer, Taemin Lee, Jianli Hu, Michael E Selzer
Failure of axon regeneration in the central nervous system (CNS) of mammals is due to both extrinsic inhibitory factors and to neuron-intrinsic factors. The importance of intrinsic factors is illustrated in the sea lamprey by the 18 pairs of large, individually identified reticulospinal (RS) neurons, whose axons are located in the same spinal cord tracts but vary greatly in their ability to regenerate after spinal cord transection (TX). The neurons that are bad regenerators also undergo very delayed apoptosis, signaled early by activation of caspases...
April 14, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29655637/analysis-of-human-blood-plasma-cell-free-dna-fragment-size-distribution-using-evagreen-chemistry-based-droplet-digital-pcr-assays
#9
M Rohan Fernando, Chao Jiang, Gary D Krzyzanowski, Wayne L Ryan
BACKGROUND: Plasma cell-free DNA (cfDNA) fragment size distribution provides important information required for diagnostic assay development. We have developed and optimized droplet digital PCR (ddPCR) assays that quantify short and long DNA fragments. These assays were used to analyze plasma cfDNA fragment size distribution in human blood. METHODS: Assays were designed to amplify 76,135, 490 and 905 base pair fragments of human β-actin gene. These assays were used for fragment size analysis of plasma cell-free, exosome and apoptotic body DNA obtained from normal and pregnant donors...
April 12, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29651333/a-novel-organ-preservation-solution-with-efficient-clearance-of-red-blood-cells-improves-kidney-transplantation-in-a-canine-model
#10
Sheng Wang, Kristyn Gumpper, Tao Tan, Xianzhang Luo, Hui Guo, Changsheng Ming, Hanying Jiang, Jiangguo Fang, Guang Du, Hua Zhu, Jianjie Ma, Zhishui Chen, Nianqiao Gong
Organ preservation solutions are designed to minimize organ damage during transplantation. A novel preservation solution, WMO-II, was developed to have a low viscosity and to improve microvasculature perfusion for kidneys. In an autologous canine transplantation model, kidney function and recovery were evaluated after organs were flushed and cold-stored with WMO-II or HTK solution, a perfusate currently approved for clinical use. The average number of red blood cells remaining in a single glomerulus after flushing with WMO-II was significantly reduced when compared with HTK solution...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29643857/a-17-kda-fragment-of-lactoferrin-associates-with-the-termination-of-inflammation-and-peptides-within-promote-resolution
#11
Aviv Lutaty, Soaad Soboh, Sagie Schif-Zuck, Orly Zeituni-Timor, Ran Rostoker, Malgorzata J Podolska, Christine Schauer, Martin Herrmann, Luis E Muñoz, Amiram Ariel
During the resolution of inflammation, macrophages engulf apoptotic polymorphonuclear cells (PMN) and can accumulate large numbers of their corpses. Here, we report that resolution phase macrophages acquire the neutrophil-derived glycoprotein lactoferrin (Lf) and fragments thereof in vivo and ex vivo . During the onset and resolving phases of inflammation in murine peritonitis and bovine mastitis, Lf fragments of 15 and 17 kDa occurred in various body fluids, and the murine fragmentation, accumulation, and release were mediated initially by neutrophils and later by efferocytic macrophages...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29642442/baculovirus-ptp2-functions-as-a-pro-apoptotic-protein
#12
Yue Han, Stineke van Houte, Monique M van Oers, Vera I D Ros
The family Baculoviridae encompasses a large number of invertebrate viruses, mainly infecting caterpillars of the order Lepidoptera. The baculovirus Spodoptera exigua multiple nucleopolyhedrovirus (SeMNPV) induces physiological and behavioral changes in its host Spodoptera exigua , as well as immunological responses, which may affect virus transmission. Here we show that the SeMNPV-encoded protein tyrosine phosphatase 2 (PTP2) induces mild apoptosis in Spodoptera frugiperda (Sf) 21 cells upon transient expression...
April 7, 2018: Viruses
https://www.readbyqxmd.com/read/29624724/inflammatory-compound-lipopolysaccharide-promotes-the-survival-of-gm-csf-cultured-dendritic-cell-via-pi3-kinase-dependent-up-regulation-of-bcl-x
#13
Shun Chen, Xinchen Li, Wenjie Zhang, Mengting Zi, Yuekang Xu
As professional antigen-presenting cells, dendritic cells (DCs) initiate and regulate immune responses against inflammation. The invasion of pathogens into the body, however, can in turn cause the change of DCs in both activity and viability, which ultimately affect immune homeostasis. The exact mechanisms that the bacteria utilize to alter the lifespan of DCs, however, are far from clear. In this study, we found that the bacterial wall compound lipopolysaccharide(LPS)can promote the survival of GM-CSF-differentiated DCs (GM-DCs)...
April 6, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29623473/copper-complex-derived-from-s-benzyldithiocarbazate-and-3-acetylcoumarin-induced-apoptosis-in-breast-cancer-cell
#14
Jhi Biau Foo, May Lee Low, Ji Hui Lim, Yan Zhi Lor, Rusyidah Zainol Abidin, Vilasini Eh Dam, Napsiah Abdul Rahman, Chaw Yee Beh, Lee Chin Chan, Chee Wun How, Yin Sim Tor, Latifah Saiful Yazan
Copper complexes have been widely studied for the anti-tumour application as cancer cells are reported to take up greater amounts of copper than normal cells. Preliminary study revealed that the newly synthesised copper complex [Cu(SBCM)2 ] displayed marked anti-proliferative towards triple-negative MDA-MB-231 breast cancer cells. Therefore, Cu(SBCM)2 has great potential to be developed as an agent for the management of breast cancer. The present study was carried out to investigate the mode of cell death induced by Cu(SBCM)2 towards MDA-MB-231 breast cancer cells...
April 5, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29618305/pro-inflammatory-cytokines-cellular-and-molecular-drug-targets-for-glucocorticoid-induced-osteoporosis-via-osteocyte
#15
Tiantian Wang, Xijie Yu, Chengqi He
Glucocorticoids are widely used to treat varieties of allergic and autoimmune diseases, however, long-term application results in glucocorticoid-induced osteoporosis (GIOP). Inflammatory cytokines: tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) play important regulatory roles in bone metabolism, but their roles in GIOP remain largely unknown. Osteocytes can modulate the formation and function of both osteoblasts and osteoclasts, directly via gap junctions, or indirectly by transferring molecule signaling...
April 4, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29616307/extracellular-vesicles-and-their-immunomodulatory-functions-in-pregnancy
#16
REVIEW
Soumyalekshmi Nair, Carlos Salomon
Extracellular vesicles (EVs) are membrane-bound vesicles released into the extracellular space by almost all types of cells. EVs can cross the physiological barriers, and a variety of biological fluids are enriched in them. EVs are a heterogeneous population of vesicles, including exosomes, microvesicles, and apoptotic bodies. The different subpopulations of vesicles can be differentiated by size and origin, in which exosomes (~100 nm and from endocytic origin) are the most studied so far. EVs have essential roles in cell-to-cell communication and are critical modulators of immune response under normal and pathological conditions...
April 3, 2018: Seminars in Immunopathology
https://www.readbyqxmd.com/read/29616011/lipid-bodies-as-sites-of-prostaglandin-e2-synthesis-during-chagas-disease-impact-in-the-parasite-escape-mechanism
#17
REVIEW
Patrícia E de Almeida, Daniel A M Toledo, Gabriel S C Rodrigues, Heloisa D'Avila
During Chagas disease, the Trypanosoma cruzi can induce some changes in the host cells in order to escape or manipulate the host immune response. The modulation of the lipid metabolism in the host phagocytes or in the parasite itself is one feature that has been observed. The goal of this mini review is to discuss the mechanisms that regulate intracellular lipid body (LB) biogenesis in the course of this parasite infection and their meaning to the pathophysiology of the disease. The interaction host-parasite induces LB (or lipid droplet) formation in a Toll-like receptor 2-dependent mechanism in macrophages and is enhanced by apoptotic cell uptake...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29611642/the-effect-of-budesonide-on-the-expression-of-ki-67-and-pcna-and-the-apoptotic-index-in-dogs-with-inflammatory-bowel-disease
#18
M Szweda, A Rychlik, M Nowicki, E Kaczmar
The aim of this study was to determine the effect of budesonide on the expression of Ki-67 and PCNA proliferative antigens and the apoptotic index in the course of inflammatory bowel disease (IBD) and to evaluate the applicability of these markers in monitoring IBD treatment in dogs. The experiment was performed on 28 dogs of different breeds and both sexes, with body weight of 6 to 20 kg, aged 6 to 10 years. The animals diagnosed with IBD were divided into four groups of 7 dogs each, including three experimental groups characterized by various severity of IBD and a control group...
December 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29607467/new-no-and-h2s-releasing-doxorubicins-as-targeted-therapy-against-chemoresistance-in-castration-resistant-prostate-cancer-in-vitro-and-in-vivo-evaluations
#19
Elisabetta Bigagli, Cristina Luceri, Maria De Angioletti, Konstantin Chegaev, Mario D'Ambrosio, Chiara Riganti, Elena Gazzano, Simona Saponara, Mariangela Longini, Francesca Luceri, Lorenzo Cinci
Chemotherapy for castration-resistant prostate cancer (CRPC) is only temporarily effective due to the onset of chemoresistance. We investigated the efficacy of NO- and H2S-releasing doxorubicins (NitDox and H2SDox) in overcoming drug resistance and evaluated their safety. New and innovative NO- and H2 S-releasing doxorubicins (NitDox and H2 SDox) showed a good intracellular accumulation and high cytotoxic activity in vitro in an androgen-independent and doxorubicin-resistant DU-145 prostate cancer cell line...
April 2, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/29604956/berberine-ameliorates-diabetic-nephropathy-by-inhibiting-tlr4-nf-%C3%AE%C2%BAb-pathway
#20
Liping Zhu, Jiakai Han, Rongrong Yuan, Lei Xue, Wuyan Pang
BACKGROUND: Diabetic nephropathy (DN) is the leading cause of end-stage renal failure, contributing to severe morbidity and mortality in diabetic patients. Berberine (BBR) has been well characterized to exert renoprotective effects in DN progression. However, the action mechanism of BBR in DN remains to be fully understood. METHODS: The DN rat model was generated by intraperitoneal injection of streptozotocin (STZ, 65 mg/kg body weight) while 30 mM high glucose (HG)-treated podocytes were used as an in vitro DN model...
March 31, 2018: Biological Research
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