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Apoptotic body

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https://www.readbyqxmd.com/read/29469618/elastic-tpu-mesh-as-abdominal-wall-inlay-significantly-reduces-defect-size-in-a-minipig-model
#1
D Heise, R Eickhoff, A Kroh, M Binnebösel, U Klinge, C D Klink, U P Neumann, A Lambertz
BACKGROUND: The open abdomen with mesh implantation, followed by early reoperation with fascial closure, is a modern surgical approach in difficult clinical situations such as severe abdominal sepsis. As early fascial closure is not possible in many cases, mesh-mediated fascial traction is helpful for conditioning of a minimized ventral hernia after open abdomen. The aim of this study was to evaluate the clinical utilization of an innovative elastic thermoplastic polyurethane mesh (TPU) as an abdominal wall inlay in a minipig model...
February 22, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29467844/target-therapy-of-trim-14-inhibits-osteosarcoma-aggressiveness-through-the-nuclear-factor-%C3%AE%C2%BAb-signaling-pathway
#2
Yi-Jiong Li, Guo-Ping Zhang, Feng Zhao, Rui-Qi Li, Shao-Jun Liu, Zeng-Ren Zhao, Xin Wang
Osteosarcoma is the most common cause of cancer-associated mortality and the prognosis is yet to be fully elucidated due to the paucity of effective therapeutic targets that significantly influence the quality of life and mean survival rates of patients with osteosarcoma. Studies have showed that tripartite motif-containing (TRIM)-14 is a member of the TRIM protein family that has a vital role in tumor progression and metastasis and promotes angiogenesis, invasion and apoptotic resistance of bone cancer. In this study, a chimeric antibody targeting TRIM-14 (Chanti-TRIM) was constructed and the molecular mechanism of target therapy for TRIM-14 was investigated in osteosarcoma cells and xenograft mice...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29464806/histopathological-and-immunophenotypic-features-of-ipilimumab-associated-colitis-compared-to-ulcerative-colitis
#3
Brittany L Adler, Maryam K Pezhouh, Amy Kim, Lan Luan, Qingfeng Zhu, Faiz Gani, Mark Yarchoan, Jonathan Chen, Lysandra Voltaggio, Alyssa Parian, Mark Lazarev, Gregory Y Lauwers, Timothy M Pawlik, Elizabeth A Montgomery, Elizabeth Jaffee, Dung T Le, Janis M Taube, Robert A Anders
BACKGROUND: Use of the immune checkpoint inhibitor ipilimumab is sometimes complicated by ipilimumab-associated colitis (Ipi-AC), an immune-mediated colitis that mimics inflammatory bowel disease. OBJECTIVE: We sought to characterize the histopathologic and immunophenotypic features of Ipi-AC, and to directly compare these features to ulcerative colitis (UC). METHODS: This is a retrospective cohort study of 22 patients with Ipi-AC, 12 patients with treatment-naïve UC, and 5 controls with diarrhea but normal endoscopic findings...
February 21, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29456710/mechanism-of-apoptosis-induction-associated-with-erk1-2-upregulation-via-goniothalamin-in-melanoma-cells
#4
Suphakorn Tangchirakhaphan, Sukanda Innajak, Sirinun Nilwarangkoon, Nudjaree Tanjapatkul, Wilawan Mahabusrakum, Ramida Watanapokasin
The present study aimed to investigate the effect of goniothalamin on apoptosis induction in the A375 melanoma cell line. Melanoma is a type of skin cancer with increased prevalence and no potential standard treatment. Goniothalamin is a plant, bioactive styrly-lactone, which has various bioactivities including anti-microbial, anti-inflammatory and anti-cancer. Apoptosis induction by goniothalamin has been studied in numerous cancer cell lines, however not in the melanoma cell line A375. The results of the MTT assay demonstrated that goniothalamin induced anti-proliferation in a dose dependent manner...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456668/fpoa-induces-the-apoptosis-of-hepg2-cells
#5
Mingjie Song, Haiying Bao, Tolgor Bau
The triterpenoid 3-acetoxylanosta-8,24-dien-21-oic acid (FPOA) is isolated from the fruiting body of Fomitopsis pinicola . The present study reports that FPOA exerts cytotoxic activity and describes the molecular mechanism of FPOA-induced apoptosis on human HepG2 hepatoma cells. FPOA exhibited significant cytotoxic effects against HepG2, MCF-7 and HeLa cells. However, FPOA was particularly cytotoxic towards HepG2 cells, with a half maximal inhibitory concentration value of 42.10 µM, thus these cells were taken forward for further analysis...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29453608/chemopreventive-action-of-imatinib-a-tyrosine-kinase-inhibitor-in-the-regulation-of-angiogenesis-and-apoptosis-in-rat-model-of-lung-cancer
#6
Kulvinder Kumar, Preety Ghanghas, S N Sanyal
The present study explored the events of angiogenesis and apoptosis in 7,12-dimethyl benz(a)anthracene (DMBA)-induced lung cancer in rat and its chemoprevention with Imatinib, a receptor tyrosine kinase inhibitor. Further, it includes lipopolysaccharide (LPS) mediating inflammation along with DMBA for the promotion of lung carcinogenesis. The animals received a single intratracheal instillation of DMBA (20 mg/kg body weight) in olive oil and LPS (0.6 mg/kg body weight) to induce tumors in 16 weeks. Besides morphology and histology of the lung tissues, RT-PCR, western blots, and immunofluorescence were performed for the expression of apoptotic and angiogenic proteins...
February 16, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29448931/effects-of-different-extracts-of-curcumin-on-tpc1-papillary-thyroid-cancer-cell-line
#7
Angelica Perna, Antonio De Luca, Laura Adelfi, Tammaro Pasquale, Bruno Varriale, Teresa Esposito
BACKGROUND: The thyroid gland is one of the largest endocrine glands in the body. The vast majority of TCs (> 90%) originate from follicular cells and are defined as differentiated thyroid cancers (DTC) and the two histological subtypes are the papillary TC with its variants and the follicular TC. Curcumin possesses a wide variety of biological functions, and thanks to its properties, it has gained considerable attention due to its profound medicinal values (Prasad, Gupta, Tyagi, and Aggarwal, Biotechnol Adv 32:1053-1064, 2014)...
February 15, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29442269/effects-of-carvacrol-on-human-fibroblast-ws-1-and-gastric-adenocarcinoma-ags-cells-in-vitro-and-on-wistar-rats-in-vivo
#8
Ayse Günes-Bayir, Abdurrahim Kocyigit, Eray Metin Güler, Mehmet Gültekin Bilgin, İlyas Samet Ergün, Agnes Dadak
Carvacrol is a natural phenolic compound found in essential oils of Lamiaceae species. In the present study, an attempt has been made to elucidate the mechanism behind the anti-cancer potential of carvacrol on human gastric adenocarcinomas (AGS) by comparing its effects on cancer cells AGS to those on normal human fibroblast (WS-1) cells, in vitro. Cytotoxicity, reactive oxygen species (ROS) generation, glutathione (GSH) levels, genotoxicity, and apoptotic effects of carvacrol (0-600 µM) were studied in both cell lines...
February 13, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29441073/macrophage-clearance-of-apoptotic-cells-a-critical-assessment
#9
REVIEW
Siamon Gordon, Annette Plüddemann
As the body continues to grow and age, it becomes essential to maintain a balance between living and dying cells. Macrophages and dendritic cells play a central role in discriminating among viable, apoptotic, and necrotic cells, as selective and efficient phagocytes, without inducing inappropriate inflammation or immune responses. A great deal has been learnt concerning clearance receptors for modified and non-self-ligands on potential targets, mediating their eventual uptake, disposal, and replacement. In this essay, we assess current understanding of the phagocytic recognition of apoptotic cells within their tissue environment; we conclude that efferocytosis constitutes a more complex process than simply removal of corpses, with regulatory interactions between the target and effector cells, which determine the outcome of this homeostatic process...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29439885/early-tissue-effects-of-stereotactic-body-radiation-therapy-for-spinal-metastases
#10
Jasper G Steverink, Stefan M Willems, Marielle E P Philippens, Nicolien Kasperts, Wietse S C Eppinga, Anne L Versteeg, Joanne M van der Velden, Salman Faruqi, Arjun Sahgal, Jorrit-Jan Verlaan
PURPOSE: Stereotactic body radiation therapy (SBRT) is a highly effective and potentially ablative treatment for complex spinal metastases. Recent data have suggested radiobiologic effects of SBRT that expand beyond the traditional concept of DNA damage. Antitumor immunity, vascular damage leading to tumor necrosis, and increased rates of tumor apoptosis have been implied; however, in-human evidence remains scarce. The present study reports unique pathologic confirmation of SBRT-induced biological effects within spinal metastases treated with preoperative SBRT...
January 6, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29434850/modulation-of-g2-m-cell-cycle-arrest-and-apoptosis-by-luteolin-in-human-colon-cancer-cells-and-xenografts
#11
Zhicheng Chen, Bo Zhang, Feng Gao, Renjie Shi
The aim of the present study was to investigate the underlying molecular mechanisms of the potent cell cycle inhibition and apoptotic effect of luteolin on LoVo human colon cancer cells. In the present study, Cell Counting kit-8 assay revealed that luteolin exerted notable cytotoxicity on LoVo cells in a dose- and time-dependent manner, with a 50% inhibitory concentration value of 66.70 and 30.47 µmol/l at the time points of 24 and 72 h, respectively. Flow cytometric analysis confirmed that luteolin promoted cell cycle arrest at the G2/M phase, and subsequently induced cell apoptosis...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434714/20-s-protopanaxadiol-induces-apoptosis-in-human-hepatoblastoma-hepg2-cells-by-downregulating-the-protein-kinase-b-signaling-pathway
#12
Zeyuan Lu, Huali Xu, Xiaofeng Yu, Yuchen Wang, Long Huang, Xin Jin, Dayun Sui
Hepatoblastoma is the most common primary liver tumor for children aged <5 years old. 20(S)-Protopanaxadiol (PPD) is a ginsenoside extracted from Pananx quinquefolium L., which inhibits tumor growth in several cancer cell lines. The purpose of the present study was to assess the anticancer activities of 20(S)-PPD in human hepatoblastoma HepG2 cells. The cytotoxicity of 20(S)-PPD on HepG2 cells was evaluated using an MTT assay. Apoptosis was detected using DAPI staining and flow cytometry. The expression of apoptosis-associated proteins was identified by western blotting...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29430581/plagioneurin-b-a-potent-isolated-compound-induces-apoptotic-signalling-pathways-and-cell-cycle-arrest-in-ovarian-cancer-cells
#13
Noraziah Nordin, Nazia Abdul Majid, Rozana Othman, Fatima Abdelmutaal Ahmed Omer, Muhammad Nazil Afiq Nasharuddin, Najihah Mohd Hashim
Plagioneurin B belongs to acetogenin group has well-established class of compounds. Acetogenin group has attracted worldwide attention in the past few years due their biological abilities as inhibitors for several types of tumour cells. Plagioneurin B was isolated via conventional chromatography and tested for thorough mechanistic apoptosis activity on human ovarian cancer cells (CAOV-3). Its structure was also docked at several possible targets using Autodock tools software. Our findings showed that plagioneurin B successfully inhibits the growth of CAOV-3 cells at IC50 of 0...
February 12, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/29428575/s-adenosylmethionine-attenuates-bile-duct-early-warm-ischemia-reperfusion-injury-after-rat-liver-transplantation
#14
Yong Tang, Hongpeng Chu, Guojun Cao, Xiaolong Du, Xiaobo Min, Chidan Wan
Warm ischemia reperfusion injury (IRI) plays a key role in biliary complication, which is a substantial vulnerability of liver transplantation. The early pathophysiological changes of IRI are characterized by an excessive inflammatory response. S-Adenosylmethionine (SAM) is an important metabolic intermediate that modulates inflammatory reactions; however, its role in bile duct warm IRI is not known. In this study, male rats were treated with or without SAM (170 μmol/kg body weight) after orthotopic autologous liver transplantation...
February 8, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29427224/chemoprevention-by-probiotics-during-1-2-dimethylhydrazine-induced-colon-carcinogenesis-in-rats
#15
Sohini Walia, Rozy Kamal, D K Dhawan, S S Kanwar
BACKGROUND: Probiotics are believed to have properties that lower the risk of colon cancer. However, the mechanisms by which they exert their beneficial effects are relatively unknown. AIM: To assess the impact of probiotics in preventing induction of colon carcinogenesis in rats. METHODS: The rats were divided into six groups viz., normal control, Lactobacillus plantarum (AdF10)-treated, Lactobacillus rhamnosus GG (LGG)-treated, 1,2-dimethylhydrazine (DMH)-treated, L...
February 9, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29421811/swiprosin-1-promotes-mitochondria-dependent-apoptosis-of-glomerular-podocytes-via-p38-mapk-pathway-in-early-stage-diabetic-nephropathy
#16
Rong-Mei Wang, Zhi-Bin Wang, Yue Wang, Wei-Ye Liu, Ya Li, Ling-Chang Tong, Su Zhang, Ding-Feng Su, Yong-Bing Cao, Ling Li, Li-Chao Zhang
BACKGROUND/AIMS: Podocyte injury, especially podocyte apoptosis, plays a major role in early-stage diabetic nephropathy (DN). Swiprosin-1, also known as EF hand domain containing 2 (EFhd2), is a Ca2+-binding protein in different cell types. However, the function of swiprosin-1 in podocytes remains unknown. METHODS: The expression and distribution of swiprosin-1 were investigated in the mouse renal glomerulus and conditionally immortalized mouse podocyte cell line MPC-5...
February 2, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29421582/ginseng-phytochemicals-as-therapeutics-in-oncology-recent-perspectives
#17
REVIEW
Fatima Majeed, Fozia Zahur Malik, Zaheer Ahmed, Asma Afreen, Muhammad Naveed Afzal, Nauman Khalid
During the last few decades, cancer has mushroomed as a major health issue; and almost all drugs used for its therapy are very toxic with lethal side effects. Complementary and alternative medicines gain popularity among health professionals in recent era owing to its preventive mechanism against side effect chemotherapeutic drugs. Efforts are focused by scientists to isolate compounds from medicinal plant that have chemotherapeutic attributes; and ability to neutralize the side effects of chemotherapy. Ginseng is an oriental medicinal recipe from Araliceae family and Panax species...
February 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29415441/in-vitro-study-of-the-cytotoxic-cytostatic-and-antigenotoxic-profile-of-hemidesmus-indicus-l-r-br-apocynaceae-crude-drug-extract-on-t-lymphoblastic-cells
#18
Eleonora Turrini, Cinzia Calcabrini, Massimo Tacchini, Thomas Efferth, Gianni Sacchetti, Alessandra Guerrini, Guglielmo Paganetto, Elena Catanzaro, Giulia Greco, Carmela Fimognari
In traditional Indian medicine, the crude drug Hemidesmus indicus root-commonly known as Indian sarsaparilla-is used alone or in poly-herbal preparations for the treatment of a wide range of diseases. The present study focuses on the cancer chemopreventive and therapeutic potential of H. indicus extracts on an acute lymphoblastic leukemia cell line (CCRF-CEM). With this aim in mind, we subjected H. indicus roots to two subsequent extractions (hydro-alcoholic extraction and soxhlet extraction). As DNA damage is an important prerequisite for the induction of mutations/cancer by genotoxic carcinogens, cancer chemoprevention may be achieved by preventing genotoxicity...
February 6, 2018: Toxins
https://www.readbyqxmd.com/read/29412795/a-new-target-for-the-treatment-of-endometrium-cancer-by-succinic-acid
#19
Elif Sinem Iplik, Tolga Catmakas, Bedia Cakmakoglu
Endometrium cancer is the most common invasive gynecologic malignancy in developed countries. Succinic acid (CO2HCH2-CH2CO2H) is a type of dibasic acid that has uncolored crystal. Succinic acid is used in bakery products and aromatized products. It is naturally found in some vegetables. Succinic acid has no adverse effects because it is metabolized by body cells and has a role in the tricarboxylic acid cycle (TCA) as a cycle media component. The TCA cycle and its enzyme components have some crucial roles for basal cell metabolism...
January 31, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29411409/the-impact-of-electric-fields-on-testis-physiopathology-sperm-parameters-and-dna-integrity-the-role-of-resveratrol
#20
R Aslankoc, N Gumral, M Saygin, N Senol, H Asci, F N Cankara, S Comlekci
This study investigated the long-term effects of electric fields (EF) which might cause physiopathological or morphological changes in the testis tissues of rats. We assumed that using resveratrol (RES) might reduce harmful effects of the EF. Thirty-two male Wistar Albino rats were randomly divided into four groups with eight animals in each; control, EF, EF + RES and RES. Malondialdehyde (MDA), superoxide dismutase, catalase, glutathione peroxidase and histopathological parameters were evaluated in testis tissue...
February 6, 2018: Andrologia
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