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Discrete choice experiment

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https://www.readbyqxmd.com/read/28628931/-the-probabilistic-efficiency-frontier-a-value-assessment-of-treatment-options-in-hepatitis-c
#1
Axel C Mühlbacher, Andrew Sadler
Background The German Institute for Quality and Efficiency in Health Care (IQWiG) recommends the concept of the efficiency frontier to assess health care interventions. The efficiency frontier supports regulatory decisions on reimbursement prices for the appropriate allocation of health care resources. Until today this cost-benefit assessment framework has only been applied on the basis of individual patient-relevant endpoints. This contradicts the reality of a multi-dimensional patient benefit. Objective The objective of this study was to illustrate the operationalization of multi-dimensional benefit considering the uncertainty in clinical effects and preference data in order to calculate the efficiency of different treatment options for hepatitis C (HCV)...
June 19, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28627110/patient-preferences-for-healthcare-delivery-through-community-pharmacy-settings-in-the-usa-a-discrete-choice-study
#2
M Feehan, M Walsh, J Godin, D Sundwall, M A Munger
WHAT IS KNOWN AND OBJECTIVE: In order to improve public health, it is necessary to facilitate patients' easy access to affordable high-quality primary health care, and one enhanced approach to do so may be to provide primary healthcare services in the community pharmacy setting. Discrete choice experiments to evaluate patient demand for services in pharmacy are relatively limited and have been hampered by a focus on only a few service alternatives, most focusing on changes in more traditional pharmacy services...
June 18, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28624978/preferences-for-breast-cancer-risk-reduction-among-brca1-brca2-mutation-carriers-a-discrete-choice-experiment
#3
Alexander Liede, Carol A Mansfield, Kelly A Metcalfe, Melanie A Price, Carrie Snyder, Henry T Lynch, Sue Friedman, Justyna Amelio, Joshua Posner, Steven A Narod, Geoffrey J Lindeman, D Gareth Evans
PURPOSE: Unaffected women who carry BRCA1 or BRCA2 mutations face difficult choices about reducing their breast cancer risk. Understanding their treatment preferences could help us improve patient counseling and inform drug trials. The objective was to explore preferences for various risk-reducing options among women with germline BRCA1/2 mutations using a discrete-choice experiment survey and to compare expressed preferences with actual behaviors. METHODS: A discrete-choice experiment survey was designed wherein women choose between hypothetical treatments to reduce breast cancer risk...
June 17, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28623526/benefit-risk-trade-offs-for-treatment-decisions-in-moderate-to-severe-rheumatoid-arthritis-focus-on-the-patient-perspective
#4
M Elaine Husni, Keith A Betts, Jenny Griffith, Yan Song, Arijit Ganguli
Given the increasing number of available treatments for rheumatoid arthritis (RA) with varying efficacy and safety profiles, it is critical to understand the level of trade-offs that patients are willing to make between benefits and risks. Adult patients with moderate to severe RA were invited to participate in a discrete choice experiment that solicited their preferences for hypothetical RA treatments. Each participant was presented with 14 choice cards asking about their preference between two hypothetical RA treatments with varying levels of efficacy, adverse events, and process-related attributes...
June 16, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28620975/decision-heuristic-or-preference-attribute-non-attendance-in-discrete-choice-problems
#5
Sebastian Heidenreich, Verity Watson, Mandy Ryan, Euan Phimister
This paper investigates if respondents' choice to not consider all characteristics of a multiattribute health service may represent preferences. Over the last decade, an increasing number of studies account for attribute non-attendance (ANA) when using discrete choice experiments to elicit individuals' preferences. Most studies assume such behaviour is a heuristic and therefore uninformative. This assumption may result in misleading welfare estimates if ANA reflects preferences. This is the first paper to assess if ANA is a heuristic or genuine preference without relying on respondents' self-stated motivation and the first study to explore this question within a health context...
June 16, 2017: Health Economics
https://www.readbyqxmd.com/read/28597379/valuing-health-risk-in-agriculture-a-choice-experiment-approach-to-pesticide-use-in-china
#6
Jianjun Jin, Wenyu Wang, Rui He, Haozhou Gong
This paper presents a choice experiment approach to investigate farmers' valuations for health risk changes associated with pesticide use in Anqiu County, China. An empirical comparison on the disparity between farmers' willingness to pay (WTP) for a health risk reduction and willingness to accept (WTA) for the same risk increase is also conducted. Respondents were randomly assigned into the WTP group or the WTA group. Four attributes (health consequence, baseline risk, risk change size, and price) were identified and included...
June 8, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28575402/factors-influencing-women-s-preferences-for-subsequent-management-in-the-event-of-incomplete-evacuation-of-the-uterus-after-misoprostol-treatment-for-miscarriage
#7
Judith E K R Hentzen, Marianne A Verschoor, Marike Lemmers, Willem M Ankum, Ben Willem J Mol, Madelon van Wely
STUDY QUESTION: What affects women's treatment preferences in the management of an incomplete evacuation of the uterus after misoprostol treatment for a first-trimester miscarriage? SUMMARY ANSWER: Women's treatment preferences in the management of an incomplete evacuation of the uterus after misoprostol treatment for miscarriage are most strongly influenced by 'the risk of a reduced fertility' followed by 'the probability of success'. WHAT IS KNOWN ALREADY: Available treatment options in miscarriage are surgical, medical or expectant management...
May 31, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28569351/valuing-eq-5d-5l-health-states-in-context-using-a-discrete-choice-experiment
#8
Amanda Cole, Koonal Shah, Brendan Mulhern, Yan Feng, Nancy Devlin
BACKGROUND: In health state valuation studies, health states are typically presented as a series of sentences, each describing a health dimension and severity 'level'. Differences in the severity levels can be subtle, and confusion about which is 'worse' can lead to logically inconsistent valuation data. A solution could be to mimic the way patients self-report health, where the ordinal structure of levels is clear. We develop and test the feasibility of presenting EQ-5D-5L health states in the 'context' of the entire EQ-5D-5L descriptive system...
May 31, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/28562125/a-discrete-choice-experiment-to-determine-uk-patient-preference-for-attributes-of-disease-modifying-treatments-in-multiple-sclerosis
#9
Catherine Bottomley, Andrew Lloyd, Gary Bennett, Nicholas Adlard
AIMS: The recent licensing of Disease Modifying Treatments (DMTs) for Multiple Sclerosis (MS) has increased available treatment options. The aim of this study was to explore MS patients' preference for the different attributes of DMTs in the UK. MATERIALS AND METHODS: Attributes (treatment characteristics) for inclusion in the discrete choice experiment (DCE) were determined through published literature and interviews with 12 people with MS. Seven attributes were selected...
June 14, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28561580/free-energy-calculations-of-ionic-hydration-consistent-with-the-experimental-hydration-free-energy-of-the-proton
#10
Haiyang Zhang, Yang Jiang, Hai Yan, Chunhua Yin, Tianwei Tan, David van der Spoel
Computational free-energy correction strategies and the choice of experimental proton hydration free energy, ΔGs(*)(H(+)), are analyzed to investigate the apparent controversy in experimental thermodynamics of ionic hydration. Without corrections, the hydration free-energy (ΔGhyd) calculations match experiments with ΔGs(*)(H(+)) = -1064 kJ/mol as reference. Using the Galvani surface potential the resulting (real) ΔGhyd are consistent with ΔGs(*)(H(+)) = -1098 kJ/mol. When applying, in an ad hoc manner, the discrete solvent correction, ΔGhyd matching the "consensus" ΔGs(*)(H(+)) of -1112 kJ/mol are obtained...
June 15, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28536998/life-impact-and-treatment-preferences-of-individuals-with-asthma-and-chronic-obstructive-pulmonary-disease-results-from-qualitative-interviews-and-focus-groups
#11
Henrik Svedsater, June Roberts, Chloe Patel, Jake Macey, Emma Hilton, Lisa Bradshaw
INTRODUCTION: The impact of asthma and chronic obstructive pulmonary disease (COPD) on individuals' lives may be substantial, yet clinical practice often focuses only on symptoms. We aimed to better understand the perspective of asthma or COPD patients and to identify condition-related burden, life impact, priorities, unmet needs, and treatment goals. METHODS: Individuals aged at least 18 years with asthma or COPD were identified by a recruitment panel via clinical referrals, support groups, consumer networks, and a patient database...
May 23, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28536955/using-discrete-choice-experiments-to-inform-the-benefit-risk-assessment-of-medicines-are-we-ready-yet
#12
Caroline M Vass, Katherine Payne
There is emerging interest in the use of discrete choice experiments as a means of quantifying the perceived balance between benefits and risks (quantitative benefit-risk assessment) of new healthcare interventions, such as medicines, under assessment by regulatory agencies. For stated preference data on benefit-risk assessment to be used in regulatory decision making, the methods to generate these data must be valid, reliable and capable of producing meaningful estimates understood by decision makers. Some reporting guidelines exist for discrete choice experiments, and for related methods such as conjoint analysis...
May 23, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28527794/farmers-preferences-for-automatic-lameness-detection-systems-in-dairy-cattle
#13
T Van De Gucht, W Saeys, A Van Nuffel, L Pluym, K Piccart, L Lauwers, J Vangeyte, S Van Weyenberg
As lameness is a major health problem in dairy herds, a lot of attention goes to the development of automated lameness-detection systems. Few systems have made it to the market, as most are currently still in development. To get these systems ready for practice, developers need to define which system characteristics are important for the farmers as end users. In this study, farmers' preferences for the different characteristics of proposed lameness-detection systems were investigated. In addition, the influence of sociodemographic and farm characteristics on farmers' preferences was assessed...
July 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28522162/implementing-shared-decision-making-for-diabetes-care-across-country-settings-what-really-matters-to-people
#14
Michela Tinelli, Panagiotis Petrou, George Samoutis, Vivie Traynor, George Olympios, Alistair McGuire
CONTEXT: Growing evidence of improved clinical outcomes and patient/professional satisfaction supports shared-decision-making (SDM) services as an effective primary care interventions for diabetes. However, only a few countries have actually adopted them (e.g. England). In other European countries (e.g. Cyprus) there is awareness that patients play a crucial role in decision-making, and SDM services could be considered as innovative strategies to promote the actual implementation of patient rights legislation and strengthen primary care...
May 10, 2017: Health Policy
https://www.readbyqxmd.com/read/28515194/do-patients-and-health-care-providers-have-discordant-preferences-about-which-aspects-of-treatments-matter-most-evidence-from-a-systematic-review-of-discrete-choice-experiments
#15
Mark Harrison, Katherine Milbers, Marie Hudson, Nick Bansback
OBJECTIVES: To review studies eliciting patient and healthcare provider preferences for healthcare interventions using discrete choice experiments (DCEs) to (1) review the methodology to evaluate similarities, differences, rigour of designs and whether comparisons are made at the aggregate level or account for individual heterogeneity; and (2) quantify the extent to which they demonstrate concordance of patient and healthcare provider preferences. METHODS: A systematic review searching Medline, EMBASE, Econlit, PsycINFO and Web of Science for DCEs using patient and healthcare providers...
May 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28511031/modeling-the-mental-health-service-utilization-decisions-of-university-undergraduates-a-discrete-choice-conjoint-experiment
#16
Charles E Cunningham, Robert B Zipursky, Bruce K Christensen, Peter J Bieling, Victoria Madsen, Heather Rimas, Stephanie Mielko, Fiona Wilson, Ivana Furimsky, Lisa Jeffs, Catharine Munn
OBJECTIVE: We modeled design factors influencing the intent to use a university mental health service. PARTICIPANTS: Between November 2012 and October 2014, 909 undergraduates participated. METHOD: Using a discrete choice experiment, participants chose between hypothetical campus mental health services. RESULTS: Latent class analysis identified three segments. A Psychological/Psychiatric Service segment (45.5%) was most likely to contact campus health services delivered by psychologists or psychiatrists...
May 16, 2017: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/28504327/preferences-for-prenatal-diagnosis-of-sickle-cell-disorder-a%C3%A2-discrete-choice-experiment-comparing-potential-service-users%C3%A2-and-health-care-providers
#17
Melissa Hill, Eugene Oteng-Ntim, Frida Forya, Mary Petrou, Stephen Morris, Lyn S Chitty
BACKGROUND: Non-invasive prenatal diagnosis (NIPD) for sickle-cell disorder (SCD) is moving closer to implementation and studies considering stakeholder preferences are required to underpin strategies for offering NIPD in clinical practice. OBJECTIVE: Determine service user and provider preferences for key attributes of prenatal diagnostic tests for SCD and examine views on NIPD. METHOD: A questionnaire that includes a discrete choice experiment was used to determine the preferences of service users and providers for prenatal tests that varied across three attributes: accuracy, time of test and risk of miscarriage...
May 15, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28494683/what-is-clearance-worth-patients-stated-risk-tolerance-for-psoriasis-treatments
#18
Angelyn O Fairchild, Shelby D Reed, F Reed Johnson, Greg Anglin, Anne M Wolka, Rebecca A Noel
PURPOSE: The purpose of this study was to provide quantitative evidence of patients' tolerance for therapeutic risks associated with psoriasis treatments that could offer psoriasis improvements beyond the PASI 75 benchmark. MATERIALS AND METHODS: We used a discrete-choice experiment in which respondents chose between competing psoriasis treatments characterized by benefits (i.e. reduced plaque severity, reduced plaque area), risks (i.e. 10-year risk of tuberculosis, 10-year risk of death from infection), and treatment regimen...
June 7, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28490902/patient-and-physician-preferences-for-anticancer-drugs-for-the-treatment-of-metastatic-colorectal-cancer-a-discrete-choice-experiment
#19
Juan Marcos González, Sarika Ogale, Robert Morlock, Joshua Posner, Brett Hauber, Nicolas Sommer, Axel Grothey
OBJECTIVE: Many publications describe preferences for colorectal cancer (CRC) screening; however, few studies elicited preferences for anticancer-drug treatment for metastatic CRC (mCRC). This study was designed to elicit preferences and risk tolerance among patients and oncologists in the USA for anticancer drugs to treat mCRC. MATERIALS AND METHODS: Patients aged 18 years or older with a self-reported diagnosis of mCRC and board-certified (or equivalent) oncologists who had treated patients with mCRC were recruited by two survey research companies from existing online patient panels in the USA...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/28483824/patients-preferences-for-gp-consultation-for-perceived-cancer-risk-in-primary-care-a-discrete-choice-experiment
#20
Katriina L Whitaker, Alex Ghanouni, Yin Zhou, Georgios Lyratzopoulos, Stephen Morris
BACKGROUND: Contacting a doctor for advice when experiencing a potential cancer symptom is an important step in early diagnosis, but barriers to consultation are commonly reported. Understanding barriers to consulting in primary care within the cancer context provides opportunities to improve earlier diagnosis of cancer AIM: To investigate patients' GP consultation preferences when presented with a potential cancer symptom, and to describe whether these preferences are mediated by variable levels of cancer risk...
June 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
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