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https://www.readbyqxmd.com/read/29153255/-management-of-hypopigmented-scars-following-burn-injuries
#1
M Schmidt, K Serror, M Chaouat, M Mimoun, D Boccara
OBJECTIVE: Permanent hypopigmentation of burn scars is a common consequence after partial and full thickness burns that heal by secondary intent, and they can cause severe aesthetic issues. The surgical goals for effective treatment of postburn hypopigmentation are to remove scar tissues, and to produce healthy melanocytes, with minimal donor site morbidity. This article reviews the current literature about the different ways to treat hypopigmentation following burn injuries and discusses the indications...
November 15, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/29142785/role-of-cord-blood-and-bone-marrow-mesenchymal-stem-cells-in-recent-deep-burn-a-case-control-prospective-study
#2
Wael Abo-Elkheir, Fawzy Hamza, Ahmed M Elmofty, Atef Emam, Magdy Abdl-Moktader, Sameh Elsherefy, Hala Gabr
RATIONALE: Burn injuries represent one of the major worldwide public health problems causing more severe physiological stress than other traumas. Effective treatment of burn injuries is mandatory to prevent the numerous life-threatening complications and possible disabilities. Stem cells, a population of multipotent cells retaining the properties of self-renewal and differentiation, are the main player in tissue regeneration after major trauma. Thus, they are thought to play a key role in wound healing inducing efficient and physiological skin regeneration...
2017: American Journal of Stem Cells
https://www.readbyqxmd.com/read/29141063/novel-treatment-using-low-dose-naltrexone-for-lichen-planopilaris
#3
Lauren C Strazzulla, Lorena Avila, Kristen Lo Sicco, Jerry Shapiro
<p>Lichen planopilaris (LPP) is a variant of lichen planus that affects the scalp causing scarring hair loss. Patients also frequently experience symptoms of scalp itch, pain, and burning. To date, there are no long-term remittive nor curative therapies available. Low-dose naltrexone has anti-inflammatory properties and has recently been described in the context of treating autoimmune conditions. This retrospective medical record review describes four LPP patients treated with low-dose (3 milligrams per day) naltrexone...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29140280/trpv3-channel-in-keratinocytes-in-scars-with-post-burn-pruritus
#4
Chun Wook Park, Hyun Ji Kim, Yong Won Choi, Bo Young Chung, So-Youn Woo, Dong-Keun Song, Hye One Kim
Post-burn pruritus is a common and distressing sequela of burn scars. Empirical antipruritic treatments usually fail to have a satisfactory outcome because of their limited selectivity and possible side effects. Therefore, novel drug targets need to be identified. Here, we aimed to investigate the possible role of protease-activated receptor 2 (PAR2) and transient receptor potential vanniloid 3 (TRPV3), along with the relation of TRPV3 to thymic stromal lymphopoietin (TSLP). Specimens from normal (unscarred) or burn-scarred (with or without pruritus) tissue were obtained from burn patients for this study...
November 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29133853/dispersion-of-tio2-nanoparticles-improves-burn-wound-healing-and-tissue-regeneration-through-specific-interaction-with-blood-serum-proteins
#5
Gulaim A Seisenbaeva, Karin Fromell, Vasiliy V Vinogradov, Aleksey N Terekhov, Andrey V Pakhomov, Bo Nilsson, Kristina Nilsson Ekdahl, Vladimir V Vinogradov, Vadim G Kessler
Burn wounds are one of the most important causes of mortality and especially morbidity around the world. Burn wound healing and skin tissue regeneration remain thus one of the most important challenges facing the mankind. In the present study we have addressed this challenge, applying a solution-stabilized dispersion TiO2 nanoparticles, hypothesizing that their ability to adsorb proteins will render them a strong capacity in inducing body fluid coagulation and create a protective hybrid material coating. The in vitro study of interaction between human blood and titania resulted at enhanced TiO2 concentrations in formation of rather dense gel composite materials and even at lower content revealed specific adsorption pattern initiating the cascade response, promising to facilitate the regrowth of the skin...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29122354/potentials-and-limitations-of-remote-fire-monitoring-in-protected-areas
#6
João Flávio Costa Dos Santos, Joyce Machado Nunes Romeiro, José Batuíra de Assis, Fillipe Tamiozzo Pereira Torres, José Marinaldo Gleriani
Protected areas (PAs) play an important role in maintaining the biodiversity and ecological processes of the site. One of the greatest challenges for the PA management in several biomes in the world is wildfires. The objective of this work was to evaluate the potentialities and limitations of the use of data obtained by orbital remote sensing in the monitoring fire occurrence in PAs. Fire Occurrence Records (FORs) were analyzed in Serra do Brigadeiro State Park, Minas Gerais, Brazil, from 2007 to 2015, using photo interpreted data from TM, ETM(+) and OLI sensors of the Landsat series and the Hot Spot Database (HSD) from the Brazilian Institute of Space Research - INPE...
November 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29106911/stem-cells-niches-and-scaffolds-applications-to-burns-and-wound-care
#7
Suzanne M Watt, Jonathan M Pleat
The importance of skin to survival, and the devastating physical and psychological consequences of scarring following reparative healing of extensive or difficult to heal human wounds, cannot be disputed. We discuss the significant challenges faced by patients and healthcare providers alike in treating these wounds. New state of the art technologies have provided remarkable insights into the role of skin stem and progenitor cells and their niches in maintaining skin homeostasis and in reparative wound healing...
October 26, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29089212/up-regulation-of-%C3%AE-1-adrenoceptors-in-burn-and-keloid-scars
#8
Peter D Drummond, Linda F Dawson, Fiona M Wood, Mark W Fear
Stimulation of α1-adrenoceptors evokes inflammatory cytokine production, boosts neurogenic inflammation and pain, and influences cellular migration and proliferation. Hence, these receptors may play a role both in normal and abnormal wound healing. To investigate this, the distribution of α1-adrenoceptors in skin biopsies of burn scars (N=17), keloid scars (N=12) and unscarred skin (N=17) was assessed using immunohistochemistry. Staining intensity was greater on vascular smooth muscle in burn scars than in unscarred tissue, consistent with heightened expression of α1-adrenoceptors...
October 28, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29089205/extension-of-flaps-associated-with-burn-scar-reconstruction-a-key-difference-between-island-and-skin-pedicled-flaps
#9
Yukiko Yoshino, Ken Kubomura, Hyakuzoh Ueda, Takuya Tsuge, Rei Ogawa
OBJECTIVE: The choice between local flap designs for burn reconstruction is largely shaped by aesthetic, vascularity, procedural complexity, and wound-closure considerations. However, another key consideration is how well specific local flap designs release post-burn scar contractures. This is because constant tension on wound edges can generate pathological scarring. However, the ability of specific local flap to release post-burn scar contractures is poorly understood. This question was addressed by this study of patients who underwent local flap surgery to release post-burn scar contractures...
October 28, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29062590/toll-like-receptor-signaling-in-burn-wound-healing-and-scarring
#10
REVIEW
Peter D'Arpa, Kai P Leung
Significance: Damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) emanate from burn-injured tissue and enter systemic circulation. Locally and systemically, they activate pattern-recognition receptors, including toll-like receptors (TLRs), to stimulate cytokine secretion, which in the severest burns typically results in extreme systemic cytokine levels, a dysfunctioning immune system, infection, impaired healing, and excessive scarring. This system-wide disruption of homeostasis can advance to life-threatening, multiorgan dysfunction syndrome...
October 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/29056026/-the-expression-of-snon-in-human-hypertrophic-scar-fibroblasts-and-the-mechanism-of-its-participation-in-hypertrophic-scar-formation
#11
F Kuang, Z Zhang, B Chen, C L Liu, Y Y Zhao, Z R Xu, X J Li
Objective: To investigate the expression of SnoN in human hypertrophic scar fibroblasts and the mechanism of its participation in hypertrophic scar formation. Methods: Eight patients with hypertrophic scar after burn in need of surgery were admitted in our unit from January to October 2013, and then hypertrophic scar tissue and normal skin tissue of full-thickness skin donor site resected by surgery of the patients were collected. Hypertrophic scar fibroblasts and normal skin fibroblasts of patients were isolated with method of explant culture and then sub-cultured...
October 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29050454/amelanotic-desmoplastic-melanoma-arising-on-an-occipito-parietal-burn-scar
#12
Ginevra Pertusi, Benedetta Miglino, Roberto Giorgione, Antonio Ramponi, Massimo Gattoni, Paolo Boggio, Stefano Astolfi, Rossana Tiberio, Federica Veronese, Francesca Graziola, Francesca Meli, Federica Bellinzona, Enrico Colombo
No abstract text is available yet for this article.
December 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29033046/eschar-removal-by-bromelain-based-enzymatic-debridement-nexobrid-%C3%A2-in-burns-an-european-consensus
#13
Christoph Hirche, Antonella Citterio, Henk Hoeksema, Ján Koller, Martina Lehner, José Ramón Martinez, Stan Monstrey, Alexandra Murray, Jan A Plock, Frank Sander, Alexandra Schulz, Benjamin Ziegler, Ulrich Kneser
Early debridement and/or eschar removal is regarded as a significant step in the treatment of deep partial and full thickness burns. It aims to control wound bioburden and allows early wound closure by conservative treatment or skin grafting. Preservation of viable dermis accompanied by early wound closure, is regarded as a necessary step to reduce scar related complication, e.g. functional limitations and/or unaesthetic scar formation. Aside from the classical techniques of surgical excision as tangential excision for eschar removal, hydro-surgery, maggot therapy, laser, enzymatic debridement have been described as additional techniques in the burn surgeon's armamentarium...
October 12, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29032981/nationwide-web-survey-of-pediatric-scalds-prevalence-and-the-relationship-with-household-vacuum-flasks
#14
Ran Zhao, Yuehou Zhang, Fanggang Ning, Yongqian Cao, Chengyu Zang, Siyuan Yin, Ru Song, Hang Jiang, Yibing Wang
OBJECTIVE: To explore the prevalence of pediatric (0-72 months old) scalds, and to clarify its relationship with household vacuum flasks. METHODS: A cross sectional online survey based on the largest social media in China. Online questionnaire was pushed twice a day to our target respondents for successive seven days. We were authorized to gain, analyze and publish the information related to this research by the Sina & Weibo data center. RESULTS: Prevalence of pediatric scalds was 5...
October 9, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29032976/the-application-of-3d-printed-transparent-facemask-for-facial-scar-management-and-its-biomechanical-rationale
#15
Yating Wei, Yan Wang, Ming Zhang, Gang Yan, Shixue Wu, Wenjun Liu, Gang Ji, Cecilia W P Li-Tsang
INTRODUCTION: Deep facial burns leave conspicuous scar to the patients and affect their quality of life. Transparent facemask has been adopted for the prevention and treatment of facial hypertrophic scars for decades. Recently, with the advancement of 3D printing, the transparent facemask could facilitate the fitting of the facial contour. However, the effectiveness of the device and its biomechanical characteristics on pressure management of hypertrophic scar would need more objective evaluation...
October 9, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29032975/comparison-of-non-surgical-methods-for-the-treatment-of-deep-partial-thickness-skin-burns-of-the-hand
#16
Ernest Zacharevskij, Gytis Baranauskas, Karolis Varkalys, Rytis Rimdeika, Darius Kubilius
This paper describes a randomized, controlled, parallel-group, single-center clinical trial designed to compare non surgical treatment methods of deep partial thickness skin burns of the hand. All patients were scanned with the Laser Doppler Imaging device to determine the depth of the burn wound. Viable keratinocytes sites were determined according to the established Perfusion Units (PU) measurement system. The trial enrolled 87 patients with hand burn wounds in the section of 260-600PU. Hand burn patients were divided into the following four groups: treated with hydrocolloid dressings; treated with mechanical debridement of monofilament polyester fibers pad and then applying silver sulfadiazine; treated with gauze dressings containing enzymatic collagenase preparation...
October 9, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29032968/early-intervention-by-captopril-does-not-improve-wound-healing-of-partial-thickness-burn-wounds-in-a-rat-model
#17
Johanneke J J Akershoek, Katrien M Brouwer, Marcel Vlig, Bouke K H L Boekema, Rob H J Beelen, Esther Middelkoop, Magda M W Ulrich
The Renin Angiotensin System is involved in fibrotic pathologies in various organs such as heart, kidney and liver. Inhibition of this system by angiotensin converting enzyme antagonists, such as Captopril, has been shown beneficial effects on these pathologies. Captopril reduced the inflammatory reaction but also directly influenced the fibrotic process. Prolonged and excessive inflammatory response is a major cause of hypertrophic scar formation in burns. We therefore evaluated the effect of Captopril on the healing of partial thickness burn wounds in a rat model...
October 9, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29031889/outcomes-important-to-burns-patients-during-scar-management-and-how-they-compare-to-the-concepts-captured-in-burn-specific-patient-reported-outcome-measures
#18
Laura L Jones, Melanie Calvert, Naiem Moiemen, Jonathan J Deeks, Jonathan Bishop, Philip Kinghorn, Jonathan Mathers
BACKGROUND: Pressure garment therapy (PGT) is an established treatment for the prevention and treatment of hypertrophic scarring; however, there is limited evidence for its effectiveness. Burn survivors often experience multiple issues many of which are not adequately captured in current PGT trial measures. To assess the effectiveness of PGT it is important to understand what outcomes matter to patients and to consider whether patient-reported outcome measures (PROMs) can be used to ascertain the effect of treatments on patients' health-related quality of life...
October 11, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29031888/below-the-surface-parents-views-on-the-factors-that-influence-treatment-adherence-in-paediatric-burn-scar-management-a-qualitative-study
#19
Nicole Andrews, Laura L Jones, Naiem Moiemen, Melanie Calvert, Philip Kinghorn, Ian Litchfield, Jonathan Bishop, Jonathan J Deeks, Jonathan Mathers
INTRODUCTION: Parents have a crucial role to play in burn scar management for their children at a time that is extremely stressful for them and their child. Scar management treatments such as pressure garment therapy (PGT) require high levels of adherence. There has been a lack of research into the factors that may influence adherence in paediatric burn scar management. This qualitative research study has investigated parents' experiences of scar management and their attempts to adhere to treatment at home...
October 11, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29031526/the-temporal-artery-island-flap-a-good-reconstructive-option-for-small-to-medium-sized-facial-defects
#20
Said Algan, Murat Kara, Hakan Cinal, Ensar Zafer Barin, Akin Inaloz, Onder Tan
PURPOSE: The reconstruction of facial defects is esthetically vital because of the unique skin color and texture of the face. The aim of this study was to show the utility of different temporal artery island flap designs for the reconstruction of upper and middle facial defects without contrast to the color and texture of the face. MATERIALS AND METHODS: This study is a retrospective case series conducted from November 2004 through May 2015. Patients older than 18 years with upper and middle facial defects smaller than 5 cm were included...
September 19, 2017: Journal of Oral and Maxillofacial Surgery
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