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https://www.readbyqxmd.com/read/29781853/the-use-of-pedicled-perforator-flaps-in-chest-reconstruction-a-systematic-review-of-outcomes-and-reliability
#1
Anne-Sophie Florczak, Benoit Chaput, Christian Herlin, Pascal Rousseau, Eric Watier, Nicolas Bertheuil
BACKGROUND: In recent years, pedicled perforator flaps have revolutionized plastic surgery by reducing donor site morbidity and ensuring larger and deeper reconstructions with local pedicled cutaneous flaps. The aim of the study was to make a systematic review of perforator pedicled propeller flaps (PPPFs) in chest reconstruction. METHODS: Pubmed and Cochrane databases were searched from 1989 to October 2016 for articles describing the use of PPPFs in chest reconstruction...
May 17, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29775632/controlled-delivery-of-a-focal-adhesion-kinase-inhibitor-results-in-accelerated-wound-closure-with-decreased-scar-formation
#2
Kun Ma, Sun Hyung Kwon, Jagannath Padmanabhan, Dominik Duscher, Artem A Trotsyuk, Yixiao Dong, Mohammed Inayathullah, Jayakumar Rajadas, Geoffrey C Gurtner
Formation of scars following wounding or trauma represents a significant healthcare burden costing the economy billions of dollars every year. Activation of focal adhesion kinase (FAK) has been shown to play a pivotal role in transducing mechanical signals to elicit fibrotic responses and scar formation during wound repair. We have previously shown that inhibition of FAK using local injections of a small molecule FAK inhibitor (FAKI) can attenuate scar development in a hypertrophic scar model. Clinical translation of FAKI therapy has been challenging, however, due to the lack of an effective drug delivery system for extensive burn injuries, blast injuries, and large excisional injuries...
May 15, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29765272/approach-to-reconstruction-of-cheek-defects
#3
REVIEW
Berkay Başağaoğlu, Mohin Bhadkamkar, Pierce Hollier, Edward Reece
The cheek is the largest facial unit with a prominent position on the face. Trauma, burns, and the resection of skin cancers constitute common sources of injury, potentially resulting in defects that, through natural healing, produce noticeable scarring. Surgical repair focuses on the reformation of three-dimensional geometries, proper establishment of symmetry, and the minimization of color and texture discrepancies to the surrounding. Defects located in this region may extend to the orbital, nasal, or buccal units and cause unique structural and functional disturbances...
May 2018: Seminars in Plastic Surgery
https://www.readbyqxmd.com/read/29753790/il-17-promotes-scar-formation-by-inducing-macrophage-infiltration
#4
Julei Zhang, Qiao Qiao, Mengdong Liu, Ting He, Jihong Shi, Xiaozhi Bai, Yijie Zhang, Yan Li, Weixia Cai, Shichao Han, Hao Guan, Dahai Hu
Trauma or burn injuries that affect the deep dermis often produce a hypertrophic scar, which limits patients' joint movement and generates an aesthetic problem. Inflammation is believed to be one of the main pathogenic mechanisms. We found that IL-17 was increased in scar tissues from patients with hypertrophic scar compared with normal skin. Recombinant mouse IL-17 was subcutaneously injected into mice that underwent full-thickness excision surgery to investigate the role of IL-17 in scar formation. Mice stimulated with IL-17 showed aggravated fibrogenesis, delayed wound healing, and increased inflammation...
May 11, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29731586/piercing-ear-keloid-excision-using-loupe-magnification-and-topical-liquid-silicone-gel-as-adjuvant
#5
Bellam A Ramesh, J Mohan
Background: Keloid is an abnormal growth of scar at the site of skin injury, which usually does not regress. It proliferates beyond the original scar. The ear keloid usually develops after piercing injury to wear ornaments. A patient usually asks for removal of keloid, as it is aesthetically unpleasant. Patient may sometimes complain of itching and pain. Aim: The study was conducted to analyze results following excision of keloid with its tract and topical silicone gel as the postsurgical adjuvant...
January 2018: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/29719102/risk-factors-for-hypertrophic-burn-scar-pain-pruritus-and-paresthesia-development
#6
Yongqiang Xiao, Yu Sun, Banghui Zhu, Kangan Wang, Pengfei Liang, Wenjun Liu, Jinfeng Fu, Shiqing Zheng, Shichu Xiao, Zhaofan Xia
Hypertrophic scar pain, pruritus, and paresthesia symptoms are major and particular concerns for burn patients. However, because no effective and satisfactory methods exist for their alleviation, the clinical treatment for these symptoms is generally considered unsatisfactory. Therefore, their risk factors should be identified and prevented during management. We reviewed the medical records of 129 post-burn hypertrophy scar patients and divided them into two groups for each of three different symptoms based on the University of North Carolina "4P" Scar Scale: patients with scar pain requiring occasional or continuous pharmacological intervention (HSc pain, n=75) vs...
May 2, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29718376/assessment-of-ablative-fractional-co2-laser-and-er-yag-laser-to-treat-hypertrophic-scars-in-a-red-duroc-pig-model
#7
Luis Rodriguez-Menocal, Stephen S Davis, Sandra Becerra, Marcela Salgado, Joel Gill, Jose Valdes, Ambar Candanedo, Shanmugasundaram Natesan, Michael Solis, Wellington Guzman, Alex Higa, Carl I Schulman, Robert J Christy, Jill Waibel, Evangelos V Badiavas
Hypertrophic scarring is a fibroproliferative process that occurs following a third-degree dermal burn injury, producing significant morbidity due to persistent pain, itching, cosmetic disfigurement, and loss of function due to contractures. Ablative fractional lasers have emerged clinically as a fundamental or standard therapeutic modality for hypertrophic burn scars. Yet the examination of their histopathological and biochemical mechanisms of tissue remodeling and comparison among different laser types has been lacking...
April 28, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29707464/one-stage-pelnac-reconstruction-in-full-thickness-skin-defects-with-bone-or-tendon-exposure
#8
Xianghong Lou, Hang Xue, Gongchi Li, Kun Wang, Pan Zhou, Binghui Li, Jianghai Chen
Dermal regeneration template, such as Integra and Pelnac, was originally designed for treating large area burn injury by inducing regeneration of dermis. To date, it has been widely applied in various acute and chronic wound sites. The present study demonstrated that application of artificial dermis alone induced 1-stage wound healing for wounds with bone or tendon exposure that should usually be repaired by flap surgery. Eight patients who presented with skin defects with bone and/or tendon exposure were treated by 1-stage Pelnac approach...
March 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29703044/effectiveness-of-aspiration-or-deroofing-for-blister-management-in-patients-with-burns-a-prospective-randomized-controlled-trial
#9
Hyung-Suk Ro, Jin Yong Shin, Mohamed Diya Sabbagh, Si-Gyun Roh, Suk Choo Chang, Nae-Ho Lee
BACKGROUND: Health care providers commonly encounter blisters when treating burn patients. The question as to whether burn blisters should be drained or deroofed has long been debated. To our knowledge, there has been no controlled, randomized clinical trial to determine which treatment is the best management option. METHODS: Between March 2016, and September 2016; 40 patients with burn blisters greater than 6-mm were enrolled in our study. Patients were randomized into 2 groups: aspiration group and deroofing group...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29698995/-burn-wound-treatment-through-enzymatic-debridement-first-experience-in-switzerland
#10
Rik Osinga, Peter Steiger, Pietro Giovanoli, Jan A Plock, Lijo Mannil
INTRODUCTION: Thermal injuries are frequent and can be associated with relevant morbidity and mortality in severe cases. Excisional debridement followed by autografting is the standard of care for deep burns, but is associated with serious potential complications. Clinical results of a novel enzymatic debridement based on Bromelain raw material extracted from the pineapple plant (Nexobrid™) were published in 2014. At the Center for Burns at the University Hospital Zürich enzymatic debridement was introduced in 2016...
April 26, 2018: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/29684639/use-of-autologous-fat-graft-and-fractiononal-co-2-laser-to-optimize-the-aesthetic-and-functional-results-in-patients-with-severe-burn-outcomes-of-the-face
#11
Simone La Padula, Barbara Hersant, Jean Paul Meningaud, Francesco D'Andrea
BACKGROUND: Facial burn outcomes are often difficult to treat. Residual scars represent a problem for aesthetic and functional concerns as well as for patient's social and psychological life. Autologous fat graft can be used in the treatment of burn outcomes, providing a sensitive improvement in the quality of the burned areas. The aim of our report is the discussion of the value of lipofilling and fractional CO2 laser in optimizing aesthetic and functional results of burn sequelae. METHODS: We treated twenty four patients with post burns scars who underwent to autologous fat graft followed by CO2 fractional laser treatment...
April 20, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29683361/human-recombinant-epidermal-growth-factor-in-skin-lesions-77-cases-in-epitelizando-project
#12
Jordi Esquirol-Caussa, Elisabeth Herrero-Vila
OBJECTIVE: To analyze compounded recombinant human Epidermal Growth Factor (rhEGF) effectiveness on skin lesions through a case series. DESIGN: Multicentric series of skin lesions treated with topical recombinant human Epidermal Growth Factor. SITE: Patients from 56 different health professionals, three different countries, two recruitment years. PARTICIPANTS: 77 patients with skin lesions, mean age 63.15 years (min = 18, max = 95); 53...
April 23, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29682893/early-intervention-in-scar-management-and-cutaneous-burns-with-autologous-platelet-rich-plasma
#13
Aura Ruiz, Daniel Cuestas, Paula Garcıa, Jose Quintero, Yency Forero, Ingrid Galvis, Oscar Velasquez
Burn management options are controversial and a multiple-handled issue. However, platelet-rich plasma is gaining interest in several medical fields. Dermatologist worldwide are already publishing some reports about its benefits and personal experiences in their practices. A 40-year-old female with a second-degree burn by VASER-type liposculpture was treated with platelet-rich plasma and followed up for 10 months. After treatment, she showed rapid improvement with an adequate cicatrization results. Some studies suggest that the use of platelet-rich plasma which contains cytokines and growth factors that participate in cellular repair and cellular differentiation, thus improving healing time and re-epithelization...
April 22, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29673408/long-term-scar-quality-after-hydrosurgical-versus-conventional-debridement-of-deep-dermal-burns-hycon-trial-study-protocol-for-a-randomized-controlled-trial
#14
Catherine M Legemate, Harold Goei, Esther Middelkoop, Irma M M H Oen, Tim H J Nijhuis, Kelly A A Kwa, Paul P M van Zuijlen, Gerard I J M Beerthuizen, Marianne K Nieuwenhuis, Margriet E van Baar, Cornelis H van der Vlies
BACKGROUND: Deep dermal burns require tangential excision of non-viable tissue and skin grafting to improve wound healing and burn-scar quality. Tangential excision is conventionally performed with a knife, but during the last decade hydrosurgery has become popular as a new tool for tangential excision. Hydrosurgery is generally thought to be a more precise and controlled manner of burn debridement leading to preservation of viable tissue and, therefore, better scar quality. Although scar quality is considered to be one of the most important outcomes in burn surgery today, no randomized controlled study has compared the effect of these two common treatment modalities with scar quality as a primary outcome...
April 19, 2018: Trials
https://www.readbyqxmd.com/read/29665489/management-impacts-on-fire-occurrence-a-comparison-of-fire-regimes-of-african-and-south-american-tropical-savannas-in-different-protected-areas
#15
Swanni T Alvarado, Thiago Sanna Freire Silva, Sally Archibald
Humans can alter fire dynamics in grassland systems by changing fire frequency, fire seasonality and fuel conditions. These changes have effects on vegetation structure and recovery, species composition, and ecosystem function. Understanding how human management can affect fire regimes is vital to detect potential changes in the resilience of plant communities, and to predict vegetation responses to human interventions. We evaluated the fire regimes of two recently protected areas in Madagascar (Ibity and Itremo NPA) and one in Brazil (Serra do Cipó NP) before and after livestock exclusion and fire suppression policies...
April 14, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29664017/specialized-fibroblast-differentiated-states-underlie-scar-formation-in-the-infarcted-mouse-heart
#16
Xing Fu, Hadi Khalil, Onur Kanisicak, Justin G Boyer, Ronald J Vagnozzi, Bryan D Maliken, Michelle A Sargent, Vikram Prasad, Iñigo Valiente-Alandi, Burns C Blaxall, Jeffery D Molkentin
Fibroblasts are a dynamic cell type that achieve selective differentiated states to mediate acute wound healing and long-term tissue remodeling with scarring. With myocardial infarction injury, cardiomyocytes are replaced by secreted extracellular matrix proteins produced by proliferating and differentiating fibroblasts. Here, we employed 3 different mouse lineage-tracing models and stage-specific gene profiling to phenotypically analyze and classify resident cardiac fibroblast dynamics during myocardial infarction injury and stable scar formation...
April 16, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29663582/the-skin-microbiome-of-wound-scars-and-unaffected-skin-in-patients-with-moderate-to-severe-burns-in-the-subacute-phase
#17
Su-Hsun Liu, Yhu-Chering Huang, Leslie Y Chen, Shu-Chuan Yu, Hsiao-Yun Yu, Shiow-Shuh Chuang
Although studies on skin microbiome of acute and chronic wounds abound, evidence on newly-built microbial communities of subacute wounds remains scant. To characterize the skin microbiome of recently-healed (scarred) burn wounds in relation to unaffected skin surfaces, we collected weekly swabs from patients with moderate to severe burns in the 3rd postburn month for 4 weeks in 2015. We performed skin type (moist, dry, and oily)-matched comparisons within six burn patients (43 pairs of swabs) and with 13 skin-healthy, control patients (22 pairs of samples) using 16S ribosomal RNA (rRNA) gene sequencing results...
April 17, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29661554/effect-of-skin-graft-thickness-on-scar-development-in-a-porcine-burn-model
#18
Danielle M DeBruler, Britani N Blackstone, Kevin L McFarland, Molly E Baumann, Dorothy M Supp, J Kevin Bailey, Heather M Powell
Animal models provide a way to investigate scar therapies in a controlled environment. It is necessary to produce uniform, reproducible scars with high anatomic and biologic similarity to human scars to better evaluate the efficacy of treatment strategies and to develop new treatments. In this study, scar development and maturation were assessed in a porcine full-thickness burn model with immediate excision and split-thickness autograft coverage. Red Duroc pigs were treated with split-thickness autografts of varying thickness: 0...
April 13, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29651853/oleogel-s10-to-accelerate-healing-of-donor-sites-monocentric-results-of-phase-iii-clinical-trial
#19
B Lipový, M Fiamoli, R Mager, Z Jelínková, J Jarkovský, Z Chaloupková, J Holoubek, I Suchánek, P Brychta
MATERIAL AND METHODS: Oleogel-S10, an ointment containing betulin-rich triterpene dry extract from birch bark was tested in an open, blindly evaluated, prospective, controlled, randomized multicentre study to improve wound healing in donor sites. The primary endpoint was time to wound closure, and secondary endpoints were scar related measurements at the time of wound closure, and 3 and 12 months after wound closure (POSAS, laser speckle contrast analysis, viscoelastic analysis). RESULTS: We report the results from a single centre (Department of Burns and Reconstructive Surgery, University Hospital Brno) of this phase III clinical trial...
2018: Acta Chirurgiae Plasticae
https://www.readbyqxmd.com/read/29651394/the-healing-effect-of-sesame-oil-camphor-and-honey-on-second-degree-burn-wounds-in-rat
#20
Reza Vaghardoost, Seyed GholamReza Mousavi Majd, Hamid Tebyanian, Hamid Babavalian, Leila Malaei, Mitra Niazi, Ali Javdani
BACKGROUND: Many studies were carried out to improve sophisticated dressings to accelerate healing processes and reduce the microbial burden in burn wounds. This study evaluated the healing effect of herbal ointment containing extract of sesame oil, camphor and honey on second degree burn wounds in rats in comparison with daily dressing oil vaseline. METHODS: Forty rats were randomly assigned to two equal groups. A deep second degree burn was formed on the back of each rat with using a standard burning technique...
January 2018: World Journal of Plastic Surgery
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