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https://www.readbyqxmd.com/read/28644207/enzymatic-versus-traditional-surgical-debridement-of-severely-burned-hands-a-comparison-of-selectivity-efficacy-healing-time-and-three-month-scar-quality
#1
Alexandra Schulz, Yaron Shoham, Lior Rosenberg, Irene Rothermund, Walther Perbix, Paul Christian Fuchs, Alexandra Lipensky, Jennifer Lynn Schiefer
Severe burns of the hands are extremely challenging, given their anatomic complexity and vulnerability. Although excisional debridement with autografting remains the standard of care (SOC), previous studies have shown that use of enzymatic debridement with bromelain (NexoBrid, EDNX) enables rapid, selective enzymatic debridement, preserving viable tissue. To date, only two studies accruing data on EDNX in this setting have been published. The current study was conducted to compare EDNX with traditional surgical debridement (TSD) of deep dermal and full-thickness hand burns...
July 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28644206/burn-patient-acuity-demographics-scar-contractures-and-rehabilitation-treatment-time-related-to-patient-outcomes-the-act-study
#2
Reg Richard, Alexis R Santos-Lozada
In 2008, the U.S. Department of Defense funded a rehabilitation study through the American Burn Association titled "Burn patient acuity demographics, scar contractures, and rehabilitation treatment time related to patient outcomes," commonly known at the ACT study. The ACT was a multi-institutional, prospective, observational, and quasirandomized investigation of the acute hospital course of 307 patients. The ACT specifically emphasized the capture of factors that may impact the physical outcome of patients with burn injury including burn severity, daily rehabilitation interventions such as mobility and splinting, and detailed skin grafting episodes...
July 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28614412/differential-effects-of-losartan-and-atorvastatin-in-partial-and-full-thickness-burn-wounds
#3
Johanneke J Akershoek, Katrien M Brouwer, Marcel Vlig, Bouke K H L Boekema, Rob H J Beelen, Esther Middelkoop, Magda M W Ulrich
Healing of burn wounds is often associated with scar formation due to excessive inflammation and delayed wound closure. To date, no effective treatment is available to prevent the fibrotic process. The Renin Angiotensin System (RAS) was shown to be involved in fibrosis in various organs. Statins (e.g. Atorvastatin), Angiotensin receptor antagonists (e.g. Losartan) and the combination of these drugs are able to reduce the local RAS activation, and reduced fibrosis in other organs. We investigated whether inhibition of the RAS could improve healing of burn wounds by treatment with Atorvastatin, Losartan or the combination of both drugs...
2017: PloS One
https://www.readbyqxmd.com/read/28606270/-keratoplasty-classification-and-primary-disease-spectrum-analysis-of-315-cases
#4
S B Cai, M Sun, S Li, L J Xu, W Wang, J Wang, W K Hu, X Y Li, P Wang, H Zhang, G G Li
Objective: To identify the primary disease spectrum and trends of surgical procedure of keratoplasty patients. Methods: Retrospective case series study. To review all patients who underwent keratoplasty at Department of ophthalmology in Tongji Hospital from January 1, 2012 to December 31, 2015. The data collected included age, sex, birthplace, and primary corneal disease and associated surgical procedures. Then the data were compared with similar papers domestic and foreign. Results: A total of 315 keratoplasties were performed during this 4-year period...
June 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28605812/transforming-growth-factor-%C3%AE-1-induced-nadph-oxidase-4-expression-and-fibrotic-response-in-conjunctival-fibroblasts
#5
Karl David Brown, Manisha H Shah, Guei-Sheung Liu, Elsa C Chan, Jonathan G Crowston, Hitesh M Peshavariya
Purpose: Fibrotic scarring after ocular surgeries and chemical burn injuries can impede clarity of the cornea and cause vision impairment. Transforming growth factor β (TGFβ) signaling pathway is known to mediate fibrotic scarring, and NADPH oxidase-derived reactive oxygen species has been shown to be an effector molecule that facilitates TGFβ1-mediated responses. The present study explores the expression profile and functional importance of NADPH oxidase (Nox) in conjunctival fibroblasts...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28602593/split-thickness-skin-graft-meshing-ratio-indications-and-common-practices
#6
Stahs Pripotnev, Anthony Papp
BACKGROUND: Split thickness skin grafting is a commonly used technique in burn surgery for resurfacing wounds that are unlikely to heal without scarring. Meshing and expanding skin grafts allow for reconstruction of larger wounds with smaller donor sites. METHODS: A retrospective chart review was performed of 210 patients with burns equal to or greater than 20% total body surface area admitted to Vancouver General Hospital between 1998 and 2014. Charts were reviewed to collect data on patient and burn demographics...
June 8, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28602587/surgical-management-of-leukoderma-after-burn-a-review
#7
REVIEW
Eric L Maranda, Mindy X Wang, Shahjahan Shareef, Bryon A Tompkins, Christopher Emerson, Evangelos V Badiavas
Burns are a common and sometimes devastating injury causing a significant amount of pain, disability, and occasionally death. Burns can have serious aesthetic and functional consequences such as pigmentary changes and formation of scar tissue. Hypopigmentation or depigmentation is often a result of partial- or full-thickness burns, which is referred to as leukoderma after burn. Thus, this study is aimed at systematically reviewing the surgical options for treating leukoderma after burn in order to gain insight into the advantages, disadvantages, and future implications of each surgical technique...
June 8, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28592937/the-pedicled-groin-flap-in-resurfacing-hand-burn-scar-release-and-other-injuries-a-five-case-series-report-and-review-of-the-literature
#8
K S Amouzou, N Berny, A El Harti, M Diouri, A Chlihi, M Ezzoubi
XX.
March 31, 2017: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/28592935/surgery-on-burns-sequelae-in-developing-countries
#9
O El Ezzi, M Dolci, C Dufour, R Bossou, A de Buys Roessingh
The purpose of this study is to analyze the effectiveness of surgery and follow-up of children operated on for burn sequelae. For many years, we have organized two missions per year to Benin and Togo, one for surgery and one for follow-up. We analyzed the files of children born in Africa and victims of burns from the years 2002 to 2011. Children were referred through a non-governmental organization (NGO) and assessed in Africa by local paediatricians before and after surgery. Treatment consisted in operating on burn sequelae such as contractures, hypertrophic scars and hard cords...
March 31, 2017: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/28576249/pediatric-burn-care-unique-considerations-in-management
#10
REVIEW
Amita R Shah, Lillian F Liao
Severe pediatric burns require a multidisciplinary team approach at a specialized pediatric burn center. Special attention must be paid to estimations of total body surface area, fluid resuscitation and metabolic demands, and adequate analgesia and sedation. Long-term effects involve scar management and psychosocial support to the child and their family. Compassionate comprehensive burn care is accomplished by a multidisciplinary team offering healing in the acute setting and preparing the child and family for long-term treatment and care...
July 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/28570453/anterolateral-thigh-flap-for-reconstruction-in-postburn-axillary-contractures
#11
Hung Chang Chen, Katie P Wu, Cheng-I Yen, Yen-Chang Hsiao, Shih-Yi Yang, Jui-Yung Yang, Cheng-Jen Chang, Shu-Yin Chang, Shiow-Shuh Chuang
BACKGROUND: Reconstruction of postburn axillary contractures is difficult and particularly challenging without healthy adjacent soft tissue for axillary scar resurfacing. In this case, a free soft-tissue transfer is among the best treatment options. Here, we describe our experience with free anterolateral thigh (ALT) flap for reconstruction in postburn axillary contractures. METHODS: We enrolled 10 patients with postburn axillary contractures from August 2003 to July 2015...
May 31, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28570443/outcomes-of-geriatric-burns-treated-as-outpatients
#12
Shinsuke Tanizaki
OBJECTIVE: Most literature about geriatric burns has focused on inpatient management; therefore, our study investigated the effects of burn characteristics and preexisting medical comorbidities on treatment outcomes for geriatric burn patients treated as outpatients. METHODS: A retrospective review was conducted for 391 patients over 65 years of age seen in the emergency department of Fukui Prefectural Hospital over a 10-year period. Charts were reviewed for age, sex, burn characteristics, burn mechanisms, preexisting medical comorbidities, and treatment outcomes...
May 31, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28566676/comparing-the-curative-efficacy-of-different-skin-grafting-methods-for-third-degree-burn-wounds
#13
Guozhen Gao, Wenjun Li, Xiangjun Chen, Sha Liu, Dexiong Yan, Xingwei Yao, Dezhi Han, Hao Dong
BACKGROUND Our research purpose was to compare the curative efficacy of different skin grafting methods for treating third-degree burn wounds. MATERIAL AND METHODS A total of 105 patients with third-degree burns were involved in this study. The burn wounds of these patients were treated using three different methods: Meek skin grafting, Stamp skin grafting, and Microskin grafting. Patients treated with different methods were placed in different groups. The skin graft survival rate, skin graft fusion time, wound healing time, total time of surgery, and 1% total body surface area (TBSA) treatment costs in each group were evaluated during and after the grafting procedures...
June 1, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28562537/recombinant-human-granulocyte-macrophage-colony-stimulating-factor-in-deep-second-degree-burn-wound-healing
#14
Dexiong Yan, Sha Liu, Xiaochun Zhao, Huijuan Bian, Xingwei Yao, Jiping Xing, Weijing Sun, Xiangjun Chen
BACKGROUND: The aim of this study was to explore the effects of recombinant human granulocyte macrophage colony stimulating factor (rhGM-CSF) on deep second-degree burn wound healing. METHODS: In this study, 95 patients with a total of 190 burn wounds were treated with either rhGM-CSF or placebo, separated into 2 groups by treatment type. Wound healing rate, wound healing time, histopathological condition, and scar scale were all compared between the 2 groups. RESULTS: The healing rates in the rhGM-CSF group were remarkably higher than those in the placebo group (P < ...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28561172/-delayed-post-burn-scar-reconstruction-of-the-dorsum-of-the-hand-with-a-collagen-elastin-based-dermal-substitute-and-split-skin-graft
#15
Patricia Beatrice Lebo, Martin Grohmann, Lars Kamolz
The hands are involved in more than 80% of severe (grade IIb-III) burn accidents. Even if appropriate initial surgical care is provided in a timely manner, this does not necessarily guarantee a satisfactory outcome in terms of function and aesthetics if interdisciplinary postoperative care and patient compliance are inadequate. In the following case, a grade IIb-III burn, this led to unstable scars on the back of both hands and an intrinsic-minus hand position, bilaterally. Our case study demonstrates that even a delayed reconstruction with a collagen- elastin-based dermal substitute and split-skin graft combined with appropriate interdisciplinary postoperative care may lead to an excellent result comparable with the function and aesthetics of healthy hands, albeit with a significant effort...
April 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/28560711/recent-advances-in-hypertrophic-scar
#16
REVIEW
Julei Zhang, Yan Li, Xiaozhi Bai, Yuehua Li, Jihong Shi, Dahai Hu
Hypertrophic scars (HTS) are predominant diseases after burn and trauma, which cause severe physiological and psychological problems. HTS have been researched for decades, and our knowledge about the mechanisms of HTS formation process has been increasing. However, the effects of currently available prevention and treatment strategies are limited. In this review, we summarize currently known mechanisms and recent studies of HTS, including extracellular matrix, matrix metalloproteinases, fibroblasts, myofibroblasts and their contraction ability, keratinocytes, growth factors, inflammatory and immune response, and stem cell treatment, hoping for a better understanding of HTS generation, development and effective translation to treatment strategies...
May 31, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28557869/a-prospective-randomized-controlled-trial-comparing-the-outpatient-treatment-of-pediatric-and-adult-partial-thickness-burns-with-suprathel-or-mepilex-ag
#17
Gabriel Hundeshagen, Vanessa N Collins, Paul Wurzer, William Sherman, Charles D Voigt, Janos Cambiaso-Daniel, Omar Nunez-Lopez, Jason Sheaffer, David N Herndon, Celeste C Finnerty, Ludwik K Branski
Modern treatment of partial thickness burns follow the paradigm of less frequent dressing changes to allow for undisturbed reepithelialization of the burn wound. We compared Mepilex Ag (M), a silver-impregnated foam dressing, and Suprathel (S), a DL-lactid acid polymer, in the outpatient treatment of partial thickness burns in pediatric and adult patients. Patients were enrolled in a randomized controlled prospective clinical trial. We monitored time to reepithelialization, wound pain, discomfort during dressing changes, and treatment cost...
May 23, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28550877/caustic-ingestion-in-children-a-review
#18
Marion Arnold, Alp Numanoglu
Various domestic or industrial chemicals may cause significant upper aerodigestive tract burns. Preventive measures should be up-scaled, especially in the developing world, to reduce the epidemic of accidental victims, largely unsupervised preschool children. External signs do not predict degree of injury. Non-invasive diagnostic screening includes radio-nuclear imaging, but early oesophago-gastroduodenoscopy remains the standard to predict stricture formation from circumferential submucosal scarring. Serial dilation is the mainstay of oesophageal stricture therapy, with oesophageal replacement reserved for severe refractory strictures...
April 2017: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/28550727/multiple-remote-sensing-data-sources-to-assess-spatio-temporal-patterns-of-fire-incidence-over-campos-amaz%C3%A3-nicos-savanna-vegetation-enclave-brazilian-amazon
#19
Daniel Borini Alves, Fernando Pérez-Cabello
Fire activity plays an important role in the past, present and future of Earth system behavior. Monitoring and assessing spatial and temporal fire dynamics have a fundamental relevance in the understanding of ecological processes and the human impacts on different landscapes and multiple spatial scales. This work analyzes the spatio-temporal distribution of burned areas in one of the biggest savanna vegetation enclaves in the southern Brazilian Amazon, from 2000 to 2016, deriving information from multiple remote sensing data sources (Landsat and MODIS surface reflectance, TRMM pluviometry and Vegetation Continuous Field tree cover layers)...
May 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28546987/current-progress-in-understanding-the-molecular-pathogenesis-of-burn-scar-contracture
#20
REVIEW
Jianglin Tan, Jun Wu
Abnormal wound healing is likely to induce scar formation, leading to dysfunction, deformity, and psychological trauma in burn patients. Despite the advancement of medical care treatment, scar contracture in burn patients remains a challenge. Myofibroblasts play a key role in scar contracture. It has been demonstrated that myofibroblasts, as well as inflammatory cells, fibroblasts, endothelial cells, and epithelial cells, secrete transforming growth factor-β1 (TGF-β1) and other cytokines, which can promote persistent myofibroblast activation via a positive regulation loop...
2017: Burns and trauma
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