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https://www.readbyqxmd.com/read/29532244/toxican-a-guide-for-grading-dermatological-adverse-events-of-cancer-treatments
#1
L Peuvrel, J Cassecuel, C Bernier, G Quéreux, M Saint-Jean, M Le Moigne, C Frénard, A Khammari, B Dréno
PURPOSE: The dermatological toxicity of cancer treatments is frequent and sometimes debilitating. Its reference classification, the NCI-CTCAE (National Cancer Institute-Common Terminology Criteria for Adverse Events), is sometimes difficult to use and does not include yet the newest toxicities. Our objective was to create a guide, TOXICAN, based on the CTCAE, which is easy to use in everyday practice and which facilitates the recognition and grading of these dermatological toxicities...
March 12, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29230478/testicular-cancer-in-monozygotic-twin-brothers-with-urticaria-pigmentosa
#2
Tatiana Péčová, Karolína Vorčáková, Markéta Žaliová, Tatiana Burjanivová, Bibiana Malicherová, Lukáš Plank, Jan Trka, Klaudia Péčová, Katarína Adamicová, Martin Péč, Juraj Pec
No abstract text is available yet for this article.
December 12, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29056081/the-risks-and-benefits-of-cannabis-in-the-dermatology-clinic
#3
Gurbir Dhadwal, Mark G Kirchhof
Cannabis ( Cannabis sativa/indica), also known as marijuana, has been used for medicinal and recreational purposes for millennia. There has been a recent trend to legalize the use of cannabis, as illustrated by the recent legalization votes in numerous states in the United States and legislation in Canada to allow recreational cannabis use. With this increasing consumption of cannabis, dermatologists will see increased pressure to prescribe cannabis and will see the side effects of cannabis use with greater frequency...
October 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28983950/epidemiology-and-comorbidities-of-patients-with-chronic-urticaria-in-korea-a-nationwide-population-based-study
#4
Bo Ri Kim, Seungkeol Yang, Jee Woong Choi, Chong Won Choi, Sang Woong Youn
Few population-based studies have focused on the epidemiology and comorbidities of chronic urticaria (CU) or chronic spontaneous urticaria (CSU). The objective of this study was to obtain information on the epidemiology and comorbidities associated with CU and CSU in Korea. We conducted a cross-sectional analysis using a national health insurance database. An algorithm based on the International Classification of Diseases, 10th revision, was used for the identification of patients with CU and CSU, and an age-sex adjusted logistic regression model was used to assess the risk of comorbidities in these patients...
January 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/28791692/skin-diseases-in-indigenous-population-retrospective-epidemiological-study-at-xingu-indigenous-park-xip-and-review-of-the-literature
#5
Jenifer S A Wu, Marcos C Florian, Douglas A Rodrigues, Jane Tomimori
BACKGROUND: Skin diseases among indigenous populations have been poorly described in the literature. Risk factors linked to habits, cultural practices, genetics, and environmental characteristics can influence the frequency and clinical presentation of these diseases. METHODS: This was a cross-sectional study conducted through a review of dermatological medical records. Data were obtained over three visits to Xingu Indigenous Park (XIP). Main dermatoses were compared by gender, age, ethnicity, and village...
August 9, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28656728/minimum-standards-on-prevention-diagnosis-and-treatment-of-occupational-and-work-related-skin-diseases-in-europe-position-paper-of-the-cost-action-standerm-td-1206
#6
J H Alfonso, A Bauer, L Bensefa-Colas, A Boman, M Bubas, L Constandt, M N Crepy, M Goncalo, J Macan, V Mahler, D Mijakoski, J M Ramada Rodilla, T Rustemeyer, P Spring, S M John, W Uter, M Wilkinson, A M Giménez-Arnau
BACKGROUND: Skin diseases constitute up to 40% of all notified occupational diseases in most European countries, predominantly comprising contact dermatitis, contact urticaria, and skin cancer. While insufficient prevention of work-related skin diseases (WRSD) is a top-priority problem in Europe, common standards for prevention of these conditions are lacking. OBJECTIVE: To develop common European standards on prevention and management of WRSD and occupational skin diseases (OSD)...
June 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28588776/management-of-infusion-reactions-associated-with-cetuximab-treatment-a-case-report
#7
Naohiro Ohshita, Yuri Ichimaru, Shoko Gamoh, Kaname Tsuji, Naotaka Kishimoto, Yasuo M Tsutsumi, Yoshihiro Momota
Cetuximab is a drug targeting the epidermal growth factor receptor, which is indicated for the treatment of unresectable advanced or recurrent head and neck or colorectal cancer. Cetuximab also enhances the cytotoxic effects of radiation in squamous cell carcinoma. The severity of infusion reactions (IR) is categorized from grade 1 to 5; grades 3 and 4 are associated with life-threatening reactions (anaphylaxis), whereas grade 5 indicates death. The incidence of grade 3-4 IR with premedication is reported to be 1...
June 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28516256/-skin-diseases-associated-with-environmental-factors
#8
REVIEW
Vera Mahler
BACKGROUND: Multiple environmental exposures may derange the regulatory and repair mechanisms of the skin and lead to dermatological disease. OBJECTIVES: Provide an overview of non-allergic skin diseases associated with environmental factors. MATERIALS AND METHODS: Review of current scientific evidence for associations of non-allergic skin diseases with environmental exposures: irritation, chemicals, infection, UV-radiation, temperature. RESULTS: Predisposition (constitution e...
June 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28511831/obstructive-sleep-apnea-and-dermatologic-disorders
#9
Madhulika A Gupta, Fiona C Simpson, Branka Vujcic, Aditya K Gupta
Obstructive sleep apnea (OSA) is present in at least 2% of women and 4% of men, and its prevalence is increasing, because a major predisposing factor for OSA is a high body mass index. Psoriasis has the most strongly substantiated link with OSA, where the relationship may be bidirectional. Dermatologic disorders may be comorbid with OSA due to several factors: (i) the heightened proinflammatory state in OSA, which can occur independent of body mass index, and may exacerbate inflammatory dermatoses; (ii) intermittent hypoxemia may promote neovascularization and tumor growth in certain cancers, such as melanoma; (iii) obesity, present in majority of OSA patients, can be associated with a heightened proinflammatory state; (iv) upper airway obstruction due to local tumors or soft tissue swelling due to physical urticaria or angioedema; (v) acute nasal congestion in the atopic patient with allergic rhinitis; (vi) dermatologic disorders associated with other OSA risk factors (eg, acanthosis nigricans and metabolic syndrome); and (vii) a high sympathetic tone (eg, in atopic dermatitis) and resultant sleep fragmentation contributing to upper airway instability during sleep...
May 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28244660/bioactive-food-chemicals-and-gastrointestinal-symptoms-a-focus-of-salicylates
#10
REVIEW
Sreepurna Malakar
Bioactive food chemicals are substances present in food that are capable of interacting with living cells causing changes in physiological functions. Salicylic acid (SA), a plant hormone involved in plant immune response, is one such bioactive food chemical. Aspirin, a commercially available SA, might play beneficial roles in cardiovascular health and colon cancer. It may also cause urticaria, angioedema, asthma, and gastrointestinal symptoms in SA-sensitive individuals. Dietary SA might exert similar beneficial effects and/or may induce similar symptoms in hypersensitive individuals...
March 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28150073/first-in-human-phase-i-study-of-sor-c13-a-trpv6-calcium-channel-inhibitor-in-patients-with-advanced-solid-tumors
#11
S Fu, H Hirte, S Welch, T T Ilenchuk, T Lutes, C Rice, N Fields, A Nemet, D Dugourd, S Piha-Paul, V Subbiah, L Liu, J Gong, D Hong, J M Stewart
Introduction This was an open-label, dose escalation (3 + 3 design), Phase I study of SOR-C13 in patients with advanced tumors of epithelial origin. Primary objectives were to assess safety/tolerability and pharmacokinetics. Secondary goals were to assess pharmacodynamics and efficacy of SOR-C13. Methods SOR-C13 was administered IV QD on days 1-3 and 8-10 of a 21-day cycle. Doses were 2.75 and 5.5 mg/kg (20-min infusion) and 1.375, 2.75, 4.13 and 6.2 mg/kg (90-min infusion). Toxicity was assessed by National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 4...
June 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/27995212/is-this-a-simple-drug-eruption-to-be-discharged
#12
Mucahit Emet, Ilker Akbas, Esra Senturk, Omer Faruk Elmas, Sahin Aslan
'Erythema Multiforme associated with Phenytoin And Cranial radiation Therapy' (EMPACT) is a very rare clinic situation and classified in EM-like drug reactions. It can be easily misdiagnosed as acute urticaria or drug eruption in ED. Initial symptoms may resemble a simple skin problem, but diagnosing and early hospitalization of the patients can be lifesaving. Here, we present a man with renal cell cancer and brain metastases who admitted to ED due to fever and generalized rash. His skin lesions beginning from his head and spreading through the torso appeared four days after the end of radiotherapy (11 days after the initial dose of both radiation and oral phenytoin)...
December 2016: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27843665/a-dog-is-a-doctor-s-best-friend-the-use-of-a-service-dog-as-a-perioperative-assistant
#13
Shannon Tew, Brad M Taicher
Service dogs are beneficial in providing assistance to people with multiple types of disabilities and medical disorders including visual impairment, physical disabilities, seizure disorders, diabetes, and mental illness. Some service animals have been trained as a screening tool for cancer. We review a case involving a 6-year-old female with a history of mast cell mediator release and immediate hypersensitivity due to the urticaria pigmentosa variant of cutaneous mastocytosis who underwent a cystourethroscopy...
2016: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/27578072/itch-management-physical-approaches-uv-phototherapy-acupuncture
#14
REVIEW
Isaac H Y Chan, Dedee F Murrell
BACKGROUND: Physical therapies refer to non-medical treatment strategies, including surgery, cryotherapy, UV phototherapy, and acupuncture. Most physical approaches are inappropriate in the context of itch. UV phototherapy and acupuncture may be effective in the management of itch. METHODS: A literature search was performed using MEDLINE and EMBASE. Bibliographies were reviewed for relevant articles. RESULTS: Narrowband UVB (311-313 nm) and UVA1 (340-400 nm) are equally effective in managing atopic dermatitis and associated itch...
2016: Current Problems in Dermatology
https://www.readbyqxmd.com/read/27225490/association-of-atopic-diseases-and-parvovirus-b19-with-acute-lymphoblastic-leukemia-in-childhood-and-adolescence-in-the-northeast-of-brazil
#15
Joacilda da Conceição Nunes, Georgia Véras de Araujo, Marcelo Tavares Viana, Emanuel Sávio Cavalcanti Sarinho
BACKGROUND: Several factors related to the immune system, such as a history of allergies and virus infections, may be associated with acute lymphoblastic leukemia (ALL). The purpose of this study was to analyze whether the presence of atopic diseases and previous infection with parvovirus B19 and Epstein-Barr virus (EBV) are associated with the development of ALL. METHODS: This case-control study was performed in two tertiary hospitals located in northeastern Brazil...
October 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27164422/wedelolactone-mitigates-uvb-induced-oxidative-stress-inflammation-and-early-tumor-promotion-events-in-murine-skin-plausible-role-of-nfkb-pathway
#16
Farrah Ali, Bilal Azhar Khan, Sarwat Sultana
UVB (Ultra-violet B) radiation is one of the major etiological factors in various dermal pathology viz. dermatitis, actinic folliculitis, solar urticaria, psoriasis and cancer among many others. UVB causes toxic manifestation in tissues by inciting inflammatory and tumor promoting events. We have designed this study to assess the anti-inflammatory and anti-tumor promotion effect of Wedelolactone (WDL) a specific IKK inhibitor. Results indicate significant restoration of anti-oxidative enzymes due to WDL treatments...
September 5, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/26933416/unilateral-arm-urticaria-presenting-as-a-paraneoplastic-manifestation-of-metachronous-bilateral-breast-cancer
#17
Pashtoon Murtaza Kasi, Tina J Hieken, Tufia C Haddad
Various paraneoplastic syndromes (PNS) are reported to be associated with breast cancer and can range from mild dermatological symptoms to severe neurological complications. Neurological and dermatological manifestations tend to be the more commonly seen paraneoplastic manifestations, albeit both are relatively rare. Diagnosis of the underlying malignancy is often delayed since the presence and severity of paraneoplastic manifestations are not dependent on the tumor size or stage. Herein, we describe a unique case of unilateral arm urticaria presenting as a paraneoplastic manifestation of metachronous bilateral breast cancer...
January 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/26800393/tak-228-formerly-mln0128-an-investigational-oral-dual-torc1-2-inhibitor-a-phase-i-dose-escalation-study-in-patients-with-relapsed-or-refractory-multiple-myeloma-non-hodgkin-lymphoma-or-waldenstr%C3%A3-m-s-macroglobulinemia
#18
Irene M Ghobrial, David S Siegel, Ravi Vij, Jesus G Berdeja, Paul G Richardson, Rachel Neuwirth, Chirag G Patel, Fabian Zohren, Jeffrey L Wolf
The PI3K/AKT/mTOR signaling pathways are frequently dysregulated in multiple human cancers, including multiple myeloma (MM), non-Hodgkin lymphoma (NHL), and Waldenström's macroglobulinemia (WM). This was the first clinical study to evaluate the safety, tolerability, maximal-tolerated dose (MTD), dose-limiting toxicity (DLT), pharmacokinetics, and preliminary clinical activity of TAK-228, an oral TORC1/2 inhibitor, in patients with MM, NHL, or WM. Thirty-nine patients received TAK-228 once daily (QD) at 2, 4, 6, or 7 mg, or QD for 3 days on and 4 days off each week (QDx3d QW) at 9 or 12 mg, in 28-day cycles...
June 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/26646757/a-phase-i-first-in-human-study-of-fp-1039-gsk3052230-a-novel-fgf-ligand-trap-in-patients-with-advanced-solid-tumors
#19
A W Tolcher, K P Papadopoulos, A Patnaik, K Wilson, S Thayer, J Zanghi, A T Gemo, W M Kavanaugh, H N Keer, P M LoRusso
BACKGROUND: Fibroblast growth factors (FGFs) play important roles in multiple cancers by supporting tumor growth and angiogenesis. FP-1039 (GSK3052230) is a FGF ligand trap consisting of the extracellular domain of FGF receptor 1 (FGFR1) fused with the Fc region of IgG1. FP-1039 binds and neutralizes multiple FGFs that normally bind FGFR1. The primary objective of this phase I study was to evaluate the safety and tolerability of FP-1039. PATIENTS AND METHODS: Eligible patients with metastatic or locally advanced solid tumors for which standard treatments were ineffective were treated with weekly doses of FP-1039 for 4 weeks, followed by 2 weeks observation...
March 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/26606786/-association-of-psoriasis-with-other-diseases
#20
REVIEW
Leo Čabrijan, Tatjana Kehler
Psoriasis is a chronic relapsing autoimmune disease with a multigenetic predisposition, which occurs in about 2% of patients in Croatia and shows variable occurrence in the world. Psoriasis can be associated with various diseases, including autoimmune diseases (pemphigus, pemphigoid, vitiligo), and slightly less with allergic diseases (atopic dermatitis, asthma, urticaria, allergic contact dermatitis). According to clinical manifestations, psoriasis appears as plaque psoriasis, erythrodermic form and pustular psoriasis...
March 2015: Acta Medica Croatica: C̆asopis Hravatske Akademije Medicinskih Znanosti
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