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https://www.readbyqxmd.com/read/28656728/minimum-standards-on-prevention-diagnosis-and-treatment-of-occupational-and-work-related-skin-diseases-in-europe-position-paper-of-the-cost-action-standerm-td-1206
#1
J H Alfonso, A Bauer, L Bensefa-Colas, A Boman, M Bubas, L Constandt, M N Crepy, M Goncalo, J Macan, V Mahler, D Mijakoski, J M Ramada Rodilla, T Rustemeyer, P Spring, S M John, W Uter, M Wilkinson, A M Giménez-Arnau
BACKGROUND: Skin diseases constitute up to 40% of all notified occupational diseases in most European countries, predominantly comprising contact dermatitis, contact urticaria, and skin cancer. While insufficient prevention of work-related skin diseases (WRSD) is a top-priority problem in Europe, common standards for prevention of these conditions are lacking. OBJECTIVE: To develop common European standards on prevention and management of WRSD and occupational skin diseases (OSD)...
June 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28588776/management-of-infusion-reactions-associated-with-cetuximab-treatment-a-case-report
#2
Naohiro Ohshita, Yuri Ichimaru, Shoko Gamoh, Kaname Tsuji, Naotaka Kishimoto, Yasuo M Tsutsumi, Yoshihiro Momota
Cetuximab is a drug targeting the epidermal growth factor receptor, which is indicated for the treatment of unresectable advanced or recurrent head and neck or colorectal cancer. Cetuximab also enhances the cytotoxic effects of radiation in squamous cell carcinoma. The severity of infusion reactions (IR) is categorized from grade 1 to 5; grades 3 and 4 are associated with life-threatening reactions (anaphylaxis), whereas grade 5 indicates death. The incidence of grade 3-4 IR with premedication is reported to be 1...
June 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28516256/-skin-diseases-associated-with-environmental-factors
#3
REVIEW
Vera Mahler
BACKGROUND: Multiple environmental exposures may derange the regulatory and repair mechanisms of the skin and lead to dermatological disease. OBJECTIVES: Provide an overview of non-allergic skin diseases associated with environmental factors. MATERIALS AND METHODS: Review of current scientific evidence for associations of non-allergic skin diseases with environmental exposures: irritation, chemicals, infection, UV-radiation, temperature. RESULTS: Predisposition (constitution e...
June 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28511831/obstructive-sleep-apnea-and-dermatologic-disorders
#4
Madhulika A Gupta, Fiona C Simpson, Branka Vujcic, Aditya K Gupta
Obstructive sleep apnea (OSA) is present in at least 2% of women and 4% of men, and its prevalence is increasing, because a major predisposing factor for OSA is a high body mass index. Psoriasis has the most strongly substantiated link with OSA, where the relationship may be bidirectional. Dermatologic disorders may be comorbid with OSA due to several factors: (i) the heightened proinflammatory state in OSA, which can occur independent of body mass index, and may exacerbate inflammatory dermatoses; (ii) intermittent hypoxemia may promote neovascularization and tumor growth in certain cancers, such as melanoma; (iii) obesity, present in majority of OSA patients, can be associated with a heightened proinflammatory state; (iv) upper airway obstruction due to local tumors or soft tissue swelling due to physical urticaria or angioedema; (v) acute nasal congestion in the atopic patient with allergic rhinitis; (vi) dermatologic disorders associated with other OSA risk factors (eg, acanthosis nigricans and metabolic syndrome); and (vii) a high sympathetic tone (eg, in atopic dermatitis) and resultant sleep fragmentation contributing to upper airway instability during sleep...
May 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28244660/bioactive-food-chemicals-and-gastrointestinal-symptoms-a-focus-of-salicylates
#5
REVIEW
Sreepurna Malakar
Bioactive food chemicals are substances present in food that are capable of interacting with living cells causing changes in physiological functions. Salicylic acid (SA), a plant hormone involved in plant immune response, is one such bioactive food chemical. Aspirin, a commercially available SA, might play beneficial roles in cardiovascular health and colon cancer. It may also cause urticaria, angioedema, asthma, and gastrointestinal symptoms in SA-sensitive individuals. Dietary SA might exert similar beneficial effects and/or may induce similar symptoms in hypersensitive individuals...
March 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28150073/first-in-human-phase-i-study-of-sor-c13-a-trpv6-calcium-channel-inhibitor-in-patients-with-advanced-solid-tumors
#6
S Fu, H Hirte, S Welch, T T Ilenchuk, T Lutes, C Rice, N Fields, A Nemet, D Dugourd, S Piha-Paul, V Subbiah, L Liu, J Gong, D Hong, J M Stewart
Introduction This was an open-label, dose escalation (3 + 3 design), Phase I study of SOR-C13 in patients with advanced tumors of epithelial origin. Primary objectives were to assess safety/tolerability and pharmacokinetics. Secondary goals were to assess pharmacodynamics and efficacy of SOR-C13. Methods SOR-C13 was administered IV QD on days 1-3 and 8-10 of a 21-day cycle. Doses were 2.75 and 5.5 mg/kg (20-min infusion) and 1.375, 2.75, 4.13 and 6.2 mg/kg (90-min infusion). Toxicity was assessed by National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 4...
June 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/27995212/is-this-a-simple-drug-eruption-to-be-discharged
#7
Mucahit Emet, Ilker Akbas, Esra Senturk, Omer Faruk Elmas, Sahin Aslan
'Erythema Multiforme associated with Phenytoin And Cranial radiation Therapy' (EMPACT) is a very rare clinic situation and classified in EM-like drug reactions. It can be easily misdiagnosed as acute urticaria or drug eruption in ED. Initial symptoms may resemble a simple skin problem, but diagnosing and early hospitalization of the patients can be lifesaving. Here, we present a man with renal cell cancer and brain metastases who admitted to ED due to fever and generalized rash. His skin lesions beginning from his head and spreading through the torso appeared four days after the end of radiotherapy (11 days after the initial dose of both radiation and oral phenytoin)...
December 2016: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27843665/a-dog-is-a-doctor-s-best-friend-the-use-of-a-service-dog-as-a-perioperative-assistant
#8
Shannon Tew, Brad M Taicher
Service dogs are beneficial in providing assistance to people with multiple types of disabilities and medical disorders including visual impairment, physical disabilities, seizure disorders, diabetes, and mental illness. Some service animals have been trained as a screening tool for cancer. We review a case involving a 6-year-old female with a history of mast cell mediator release and immediate hypersensitivity due to the urticaria pigmentosa variant of cutaneous mastocytosis who underwent a cystourethroscopy...
2016: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/27578072/itch-management-physical-approaches-uv-phototherapy-acupuncture
#9
REVIEW
Isaac H Y Chan, Dedee F Murrell
BACKGROUND: Physical therapies refer to non-medical treatment strategies, including surgery, cryotherapy, UV phototherapy, and acupuncture. Most physical approaches are inappropriate in the context of itch. UV phototherapy and acupuncture may be effective in the management of itch. METHODS: A literature search was performed using MEDLINE and EMBASE. Bibliographies were reviewed for relevant articles. RESULTS: Narrowband UVB (311-313 nm) and UVA1 (340-400 nm) are equally effective in managing atopic dermatitis and associated itch...
2016: Current Problems in Dermatology
https://www.readbyqxmd.com/read/27225490/association-of-atopic-diseases-and-parvovirus-b19-with-acute-lymphoblastic-leukemia-in-childhood-and-adolescence-in-the-northeast-of-brazil
#10
Joacilda da Conceição Nunes, Georgia Véras de Araujo, Marcelo Tavares Viana, Emanuel Sávio Cavalcanti Sarinho
BACKGROUND: Several factors related to the immune system, such as a history of allergies and virus infections, may be associated with acute lymphoblastic leukemia (ALL). The purpose of this study was to analyze whether the presence of atopic diseases and previous infection with parvovirus B19 and Epstein-Barr virus (EBV) are associated with the development of ALL. METHODS: This case-control study was performed in two tertiary hospitals located in northeastern Brazil...
October 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27164422/wedelolactone-mitigates-uvb-induced-oxidative-stress-inflammation-and-early-tumor-promotion-events-in-murine-skin-plausible-role-of-nfkb-pathway
#11
Farrah Ali, Bilal Azhar Khan, Sarwat Sultana
UVB (Ultra-violet B) radiation is one of the major etiological factors in various dermal pathology viz. dermatitis, actinic folliculitis, solar urticaria, psoriasis and cancer among many others. UVB causes toxic manifestation in tissues by inciting inflammatory and tumor promoting events. We have designed this study to assess the anti-inflammatory and anti-tumor promotion effect of Wedelolactone (WDL) a specific IKK inhibitor. Results indicate significant restoration of anti-oxidative enzymes due to WDL treatments...
September 5, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/26933416/unilateral-arm-urticaria-presenting-as-a-paraneoplastic-manifestation-of-metachronous-bilateral-breast-cancer
#12
Pashtoon Murtaza Kasi, Tina J Hieken, Tufia C Haddad
Various paraneoplastic syndromes (PNS) are reported to be associated with breast cancer and can range from mild dermatological symptoms to severe neurological complications. Neurological and dermatological manifestations tend to be the more commonly seen paraneoplastic manifestations, albeit both are relatively rare. Diagnosis of the underlying malignancy is often delayed since the presence and severity of paraneoplastic manifestations are not dependent on the tumor size or stage. Herein, we describe a unique case of unilateral arm urticaria presenting as a paraneoplastic manifestation of metachronous bilateral breast cancer...
January 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/26800393/tak-228-formerly-mln0128-an-investigational-oral-dual-torc1-2-inhibitor-a-phase-i-dose-escalation-study-in-patients-with-relapsed-or-refractory-multiple-myeloma-non-hodgkin-lymphoma-or-waldenstr%C3%A3-m-s-macroglobulinemia
#13
Irene M Ghobrial, David S Siegel, Ravi Vij, Jesus G Berdeja, Paul G Richardson, Rachel Neuwirth, Chirag G Patel, Fabian Zohren, Jeffrey L Wolf
The PI3K/AKT/mTOR signaling pathways are frequently dysregulated in multiple human cancers, including multiple myeloma (MM), non-Hodgkin lymphoma (NHL), and Waldenström's macroglobulinemia (WM). This was the first clinical study to evaluate the safety, tolerability, maximal-tolerated dose (MTD), dose-limiting toxicity (DLT), pharmacokinetics, and preliminary clinical activity of TAK-228, an oral TORC1/2 inhibitor, in patients with MM, NHL, or WM. Thirty-nine patients received TAK-228 once daily (QD) at 2, 4, 6, or 7 mg, or QD for 3 days on and 4 days off each week (QDx3d QW) at 9 or 12 mg, in 28-day cycles...
June 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/26646757/a-phase-i-first-in-human-study-of-fp-1039-gsk3052230-a-novel-fgf-ligand-trap-in-patients-with-advanced-solid-tumors
#14
A W Tolcher, K P Papadopoulos, A Patnaik, K Wilson, S Thayer, J Zanghi, A T Gemo, W M Kavanaugh, H N Keer, P M LoRusso
BACKGROUND: Fibroblast growth factors (FGFs) play important roles in multiple cancers by supporting tumor growth and angiogenesis. FP-1039 (GSK3052230) is a FGF ligand trap consisting of the extracellular domain of FGF receptor 1 (FGFR1) fused with the Fc region of IgG1. FP-1039 binds and neutralizes multiple FGFs that normally bind FGFR1. The primary objective of this phase I study was to evaluate the safety and tolerability of FP-1039. PATIENTS AND METHODS: Eligible patients with metastatic or locally advanced solid tumors for which standard treatments were ineffective were treated with weekly doses of FP-1039 for 4 weeks, followed by 2 weeks observation...
March 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/26606786/-association-of-psoriasis-with-other-diseases
#15
REVIEW
Leo Čabrijan, Tatjana Kehler
Psoriasis is a chronic relapsing autoimmune disease with a multigenetic predisposition, which occurs in about 2% of patients in Croatia and shows variable occurrence in the world. Psoriasis can be associated with various diseases, including autoimmune diseases (pemphigus, pemphigoid, vitiligo), and slightly less with allergic diseases (atopic dermatitis, asthma, urticaria, allergic contact dermatitis). According to clinical manifestations, psoriasis appears as plaque psoriasis, erythrodermic form and pustular psoriasis...
March 2015: Acta Medica Croatica: C̆asopis Hravatske Akademije Medicinskih Znanosti
https://www.readbyqxmd.com/read/26383021/helicobacter-pylori-a-significant-and-treatable-cause-of-chronic-urticaria-and-angioedema
#16
Marjohn M Rasooly, Nancy A Moye, Arnold S Kirshenbaum
Two outpatient medical offices evaluated 204 patients with chronic urticaria during 2012. This article presents a retrospective study showing that 10% of patients with chronic urticaria may be infected with H. pylori. Furthermore, eradication of infection can be followed by remission of urticaria, reduced morbidity from gastric ulcers, and cancer.
October 16, 2015: Nurse Practitioner
https://www.readbyqxmd.com/read/26372548/-acute-blue-urticaria-following-subcutaneous-injection-of-patent-blue-dye
#17
A Hamelin, A Vial-Dupuy, B Lebrun-Vignes, C Francès, A Soria, S Barete
BACKGROUND: Patent blue (PB) is a lymphatic vessel dye commonly used in France for sentinel lymph node detection in breast cancer, and less frequently in melanoma, and which may induce hypersensitivity reactions. We report a case of acute blue urticaria occurring within minutes of PB injection. PATIENTS AND METHODS: Ten minutes after PB injection for sentinel lymph node detection during breast cancer surgery, a 49-year-old woman developed generalised acute blue urticaria and eyelid angioedema without bronchospasm or haemodynamic disturbance, but requiring discontinuation of surgery...
November 2015: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/26355315/-visible-light-and-human-skin-review
#18
REVIEW
A Tsibadze, E Chikvaidze, A Katsitadze, I Kvachadze, N Tskhvediani, A Chikviladze
Biological effect of a visible light depends on extend of its property to penetrate into the tissues: the greater is a wavelength the more is an effect of a radiation. An impact of a visible light on the skin is evident by wave and quantum effects. Quanta of a visible radiation carry more energy than infrared radiation, although an influence of such radiation on the skin is produced by the light spectrum on the boarder of the ultraviolet and the infrared rays and is manifested by thermal and chemical effects...
September 2015: Georgian Medical News
https://www.readbyqxmd.com/read/26246330/incidence-of-adverse-cutaneous-drug-reactions-in-22-866-chinese-inpatients-a-prospective-study
#19
Xiao-Yin Tian, Bing Liu, Hao Shi, Zi-Ran Zhao, Xi-Ping Zhou, Tao Zhang, Qiu-Ning Sun, Ya-Gang Zuo
Cutaneous adverse drug reactions (ADRs) are common. However, no prospective study assessing cutaneous ADRs is available for Chinese populations. This study aimed to assess the incidence, manifestations, causative drugs, and other factors related to cutaneous ADRs. A total of 22,866 inpatients were surveyed prospectively from January to April 2012 at the Peking Union Medical College Hospital. Only cutaneous ADRs induced by systemic drugs were considered. Fifty cases were confirmed as cutaneous ADRs, for an estimated incidence of 2...
November 2015: Archives of Dermatological Research
https://www.readbyqxmd.com/read/26051697/comparing-cutaneous-research-funded-by-the-us-national-institutes-of-health-nih-with-the-us-skin-disease-burden
#20
COMPARATIVE STUDY
Erika L Hagstrom, Shivani Patel, Chante Karimkhani, Lindsay N Boyers, Hywel C Williams, Roderick J Hay, Martin A Weinstock, April W Armstrong, Cory A Dunnick, David J Margolis, Robert P Dellavalle
BACKGROUND: Disease burden should be an important component for guiding research funding. OBJECTIVE: We sought to examine the relationship between dermatologic research funded from 2012 to 2013 by the National Institutes of Health (NIH) and US skin disease burden as measured by disability-adjusted life years in the Global Burden of Disease 2010 study. METHODS: A cross-sectional analysis was independently performed by 2 researchers who matched projects from the 2012 to 2013 NIH Research Portfolio Online Reporting Tools with 15 skin conditions and their respective disability-adjusted life years from Global Burden of Disease 2010...
September 2015: Journal of the American Academy of Dermatology
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