keyword
https://read.qxmd.com/read/38537086/effect-of-dexmedetomidine-on-the-incidence-of-postoperative-acute-kidney-injury-in-living-donor-liver-transplantation-recipients-a-randomized-controlled-trial
#1
JOURNAL ARTICLE
Hye-Mee Kwon, Sa-Jin Kang, Sang-Bin Han, Jae Hwan Kim, Sung-Hoon Kim, In-Gu Jun, Jun-Gol Song, Gyu-Sam Hwang
BACKGROUND: Acute kidney injury (AKI) is one of the most common complications after living-donor liver transplantation (LDLT) that has great impact on recipient and graft outcomes. Dexmedetomidine is reported to decrease the incidence of AKI. In the current study, we investigated whether intraoperative dexmedetomidine infusion would reduce the AKI following LDLT. MATERIAL AND METHODS: In total, 205 adult patients undergoing elective LDLT were randomly assigned to the dexmedetomidine group (n=103) or the control group (n=102)...
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38504576/utility-of-a-fusion-protein-t-cell-co-stimulation-blocker-belatacept-in-heart-transplant-recipients-real-world-experience-from-a-high-volume-center
#2
JOURNAL ARTICLE
Daniel Oren, Matan Uriel, Cathrine M Moeller, Andrea Fernandez Valledor, Ersilia M DeFilippis, Dor Lotan, Paolo C Colombo, Melana Yuzefpolskaya, Veli K Topkara, Kevin J Clerkin, Jayant K Raikhelkar, Justin A Fried, David Kyung Taek Oh, David Bae, Eddie Lin, Kleanthis Theodoropoulos, Yoshifumi Naka, Koji Takeda, Jason Choe, Douglas L Jennings, David Majure, Farhana Latif, Gabriel Sayer, Nir Uriel
BACKGROUND: Belatacept (BTC), a fusion protein, selectively inhibits T-cell co-stimulation by binding to the CD80 and CD86 receptors on antigen-presenting cells (APCs) and has been used as immunosuppression in adult renal transplant recipients. However, data regarding its use in heart transplant (HT) recipients are limited. This retrospective cohort study aimed to delineate BTC's application in HT, focusing on efficacy, safety, and associated complications at a high-volume HT center. METHODS: A retrospective cohort study was conducted of patients who underwent HT between January 2017 and December 2021 and subsequently received BTC as part of their immunosuppressive regimen...
March 2024: Clinical Transplantation
https://read.qxmd.com/read/38485664/the-role-of-anticomplement-therapy-in-the-management-of-the-kidney-allograft
#3
REVIEW
Mehmet Kanbay, Sidar Copur, Zeynep Y Yilmaz, Dilek Ertoy Baydar, Ilmay Bilge, Caner Susal, Burak Kocak, Alberto Ortiz
As the number of patients living with kidney failure grows, the need also grows for kidney transplantation, the gold standard kidney replacement therapy that provides a survival advantage. This may result in an increased rate of transplantation from HLA-mismatched donors that increases the rate of antibody-mediated rejection (AMR), which already is the leading cause of allograft failure. Plasmapheresis, intravenous immunoglobulin therapy, anti-CD20 therapies (i.e., rituximab), bortezomib and splenectomy have been used over the years to treat AMR as well as to prevent AMR in high-risk sensitized kidney transplant recipients...
March 2024: Clinical Transplantation
https://read.qxmd.com/read/38468698/association-between-diabetic-status-and-risk-of-all-cause-and-cause-specific-mortality-on-dialysis-following-first-kidney-allograft-loss
#4
JOURNAL ARTICLE
Amali Samarasinghe, Germaine Wong, Armando Teixeira-Pinto, David W Johnson, Carmel Hawley, Helen Pilmore, William R Mulley, Matthew A Roberts, Kevan R Polkinghorne, Neil Boudville, Christopher E Davies, Andrea K Viecelli, Esther Ooi, Nicholas G Larkins, Charmaine Lok, Wai H Lim
BACKGROUND: Diabetes mellitus (DM) is associated with a greater risk of mortality in kidney transplant patients, primarily driven by a greater risk of cardiovascular disease (CVD)-related mortality. However, the associations between diabetes status at time of first allograft loss and mortality on dialysis remain unknown. METHODS: All patients with failed first kidney allografts transplanted in Australia and New Zealand between 2000 and 2020 were included. The associations between diabetes status at first allograft loss, all-cause and cause-specific mortality were examined using competing risk analyses, separating patients with diabetes into those with pre-transplant DM or post-transplant diabetes mellitus (PTDM)...
March 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38467465/histopathology-of-congestive-nephropathy-a-case-description-and-literature-review
#5
Faeq Husain-Syed, Janani Rangaswami, Julio Núñez, Susanne Skrzypek, Christian Jux, Hermann-Josef Gröne, Horst-Walter Birk
Congestive nephropathy is an underappreciated manifestation of cardiorenal syndrome and is characterized by a potentially reversible kidney dysfunction caused by a reduced renal venous outflow secondary to right-sided heart failure or intra-abdominal hypertension. To date, the histological diagnostic criteria for congestive nephropathy have not been defined. We herein report a case of acute renal dysfunction following cardiac allograft failure and present a review of the relevant literature to elucidate the current understanding of the disease...
March 11, 2024: ESC Heart Failure
https://read.qxmd.com/read/38446250/transplant-nephrectomy-indication-surgical-approach-and-complications-experiences-from-a-single-transplantation-center
#6
JOURNAL ARTICLE
Josef Mang, Josephine Haag, Lutz Liefeldt, Klemens Budde, Robert Peters, Sebastian L Hofbauer, Matthias Schulz, Sarah Weinberger, Julia Dagnæs-Hansen, Andreas Maxeiner, Bernhard Ralla, Frank Friedersdorff
PURPOSE: Management of a failed kidney allograft, and the question whether it should be removed is a challenging task for clinicians. The reported risks for transplant nephrectomy (TN) vary, and there is no clear recommendation on indications or surgical approach that should be used. This study gives an overview of indications, compares surgical techniques, and identifies risk factors for higher morbidity. METHODS: Retrospective analysis was conducted on all transplant nephrectomies performed between 2005 and 2020 at Charité Hospital Berlin, Department of Urology...
March 6, 2024: World Journal of Urology
https://read.qxmd.com/read/38445391/similar-incidence-of-graft-glomerulonephritis-in-recipients-with-definitively-diagnosed-glomerulonephritis-and-those-with-unknown-etiology-a-retrospective-observational-study
#7
JOURNAL ARTICLE
Qianqian Wu, Xuefeng Ni, Jingsong Chen, Dongrui Cheng, Mingchao Zhang, Kenan Xie, Xue Li, Jiqiu Wen
OBJECTIVE: In China, most of the patients who underwent kidney transplants have unknown causes of end-stage renal disease (uESRD). However, little is known regarding the incidence of graft glomerulonephritis (GN) and graft survival in kidney transplant recipients (KTRs) with uESRD. METHODS: In this retrospective cohort study, 473 of the 565 KTRs who underwent kidney transplantation (KTx) from 2015 to 2020 were included. We mainly observed the occurrence of graft GN between uESRD group and definitively diagnosed GN group, and repeatedly compared after propensity score matching (PSM)...
December 2024: Renal Failure
https://read.qxmd.com/read/38427308/investigating-the-role-of-ultrasound-based-shear-wave-elastography-in-kidney-transplanted-patients-correlation-between-non-invasive-fibrosis-detection-kidney-dysfunction-and-biopsy-results-a-systematic-review-and-meta-analysis
#8
JOURNAL ARTICLE
Teodóra Filipov, Brigitta Teutsch, Anett Szabó, Attila Forintos, Júlia Ács, Alex Váradi, Péter Hegyi, Tibor Szarvas, Nándor Ács, Péter Nyirády, Pál Ákos Deák
INTRODUCTION: Interstitial fibrosis and tubular atrophy are leading causes of renal allograft failure. Shear wave elastography could be a promising noninvasive method for providing information on the state of the kidney, with specific regard to fibrosis but currently available data in the literature are controversial. Our study aimed to analyze the correlation between shear wave elastography and various kidney dysfunction measures. METHODS: This review was registered on PROSPERO (CRD42021283152)...
March 1, 2024: Journal of Nephrology
https://read.qxmd.com/read/38426492/a-humanized-il-2-mutein-expands-tregs-and-prolongs-transplant-survival-in-preclinical-models
#9
JOURNAL ARTICLE
Orhan Efe, Rodrigo B Gassen, Leela Morena, Yoshikazu Ganchiku, Ayman Al Jurdi, Isadora T Lape, Pedro Ventura-Aguiar, Christian LeGuern, Joren C Madsen, Zachary Shriver, Gregory J Babcock, Thiago J Borges, Leonardo V Riella
Long-term organ transplant survival remains suboptimal, and life-long immunosuppression predisposes transplant recipients to an increased risk of infection, malignancy, and kidney toxicity. Promoting the regulatory arm of the immune system by expanding Tregs may allow immunosuppression minimization and improve long-term graft outcomes. While low-dose IL-2 treatment can expand Tregs, it has a short half-life and off-target expansion of NK and effector T cells, limiting its clinical applicability. Here, we designed a humanized mutein IL-2 with high Treg selectivity and a prolonged half-life due to the fusion of an Fc domain, which we termed mIL-2...
March 1, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38425049/advancing-the-application-of-the-analytical-renal-pathology-system-in-allograft-iga-nephropathy-patients
#10
JOURNAL ARTICLE
Xumeng Liu, Huiwen Fang, Dongmei Liang, Qunjuan Lei, Jiaping Wang, Feng Xu, Shaoshan Liang, Dandan Liang, Fan Yang, Heng Li, Jianghua Chen, Yuan Ni, Guotong Xie, Caihong Zeng
BACKGROUND: The analytical renal pathology system (ARPS) based on convolutional neural networks has been used successfully in native IgA nephropathy (IgAN) patients. Considering the similarity of pathologic features, we aim to evaluate the performance of the ARPS in allograft IgAN patients and broaden its implementation. METHODS: Biopsy-proven allograft IgAN patients from two different centers were enrolled for internal and external validation. We implemented the ARPS to identify glomerular lesions and intrinsic glomerular cells, and then evaluated its performance...
December 2024: Renal Failure
https://read.qxmd.com/read/38419156/invasive-fungal-infections-in-inpatient-solid-organ-transplant-recipients-with-covid-19-a-multicenter-retrospective-cohort
#11
JOURNAL ARTICLE
Nitipong Permpalung, Teresa Po-Yu Chiang, Kasama Manothummetha, Darin Ostrander, Kausik Datta, Dorry L Segev, Christine M Durand, Heba H Mostafa, Sean X Zhang, Allan B Massie, Kieren A Marr, Robin K Avery
BACKGROUND: The prevalence and outcomes of COVID-19-associated invasive fungal infections (CAIFIs) in solid organ transplant recipients (SOTRs) remain poorly understood. METHODS: A retrospective cohort study of SOTRs with COVID-19 admitted to 5 hospitals within Johns Hopkins Medicine was performed between March 2020 and March 2022. Cox regression multilevel mixed-effects ordinal logistic regression was used. RESULTS: In the cohort of 276 SOTRs, 22 (8%) developed IFIs...
February 29, 2024: Transplantation
https://read.qxmd.com/read/38385371/kidney-retransplantation-in-children
#12
REVIEW
Bassam Saeed
Pediatric kidney transplant recipients will likely require a retransplant in their lifetime. Although the significant advances in clinical management and newer immunosuppressive agents have had a significant effect to improve short-term allograft function, it is apparent that long-term allograft function remains suboptimal. Therefore, it is likely that most pediatric renal allograft recipients will require 1 or more retransplants during their lifetime. In the West, an increasing number of patients on the deceased donor wait list are awaiting a retransplant; in the US, 15% of current annual transplants are retransplants...
January 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38375952/outcomes-after-kidney-transplant-alone-in-patients-with-cirrhosis-a-case-control-study
#13
JOURNAL ARTICLE
Rohit R Nathani, Stephanie M Rutledge, Carolina S Villarroel, Ron Shapiro, Sander S Florman, Fasika M Tedla, Thomas D Schiano, Gene Y Im
BACKGROUND: Guidelines recommend kidney transplant alone (KTA) in compensated cirrhosis based on a few small studies, but this is not widely performed despite its potential benefit to patients and the organ supply. Our aim was to determine the outcomes of KTA in patients with compensated cirrhosis. STUDY DESIGN: From 1/2012 to 12/2021, outcomes in KTA recipients with compensated cirrhosis were retrospectively compared to patients with chronic liver disease (CLD) but no cirrhosis...
February 2024: Clinical Transplantation
https://read.qxmd.com/read/38375934/cannabis-use-is-associated-with-reduced-access-to-kidney-transplantation-and-an-increased-risk-of-acute-rejection-post-transplant
#14
JOURNAL ARTICLE
Sonia Rodríguez-Ramírez, Evan Tang, Yanhong Li, Olusegun Famure, Istvan Mucsi, Sang Joseph Kim
BACKGROUND: The association between cannabis use and access to waitlisting, transplantation, and post-transplant outcomes remains uncertain. METHODS: Patients referred for kidney transplant (KT) to the University Health Network from January 1, 2003, to June 30, 2020, and followed until December 31, 2020, were included. Predictors of reported cannabis use were examined using a logistic regression model. The association between cannabis use and time to clearance for KT, undergoing KT, and post-transplant outcomes was evaluated using Cox proportional hazards models...
February 2024: Clinical Transplantation
https://read.qxmd.com/read/38374662/hepatic-artery-vasospasm-masquerading-as-early-hepatic-artery-thrombosis-in-progressive-familial-intrahepatic-cholestasis-3-a-case-report
#15
Divij Jayant, Swapnesh Sahu, Basil Babu, Cherring Tandup, Arunanshu Behera
Post-liver transplant (LT) hepatic artery vasospasm is a vascular complication that is not well recognized and its incidence is not known. As a possible sequela to vasospasm, hepatic artery thrombosis is the second major cause of allograft failure after primary nonfunction and its reported incidence is 2.9% in adults and 8.3% in pediatric LT. Lacuna in knowledge regarding early hepatic artery vasospasm post-LT makes it a difficult condition to diagnose and treat, as the initial ischemic insult on graft can have devastating consequences...
February 20, 2024: Korean journal of transplantation
https://read.qxmd.com/read/38367259/donor-fat-to-muscle-ratio-and-kidney-transplant-outcomes-a%C3%A2-proposition-of-metabolic-memory
#16
JOURNAL ARTICLE
Youn Kyung Kee, Juhan Lee, Bo Young Nam, Young Su Joo, Shin-Wook Kang, Kyu Ha Huh, Jung Tak Park
AIMS: The impact of donor abdominal fat-to-muscle ratio (FMR) on kidney transplant (KT) outcomes was assessed. Given the transient nature of the donor's metabolic environment in transplant recipients, this study investigated the capacity of body composition to induce metabolic memory effects. MATERIALS AND METHODS: KT patients (n = 895) who received allografts from living donors (2003-2013) were included. Donor fat and muscle were quantified using pre-KT abdominal computed tomography scans...
February 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38345067/value-of-original-and-modified-pathological-scoring-systems-for-prognostic-prediction-in-paraffin-embedded-donor-kidney-core-biopsy
#17
JOURNAL ARTICLE
Jinghong Tan, Huanxi Zhang, Longshan Liu, Jun Li, Qian Fu, Yan Li, Chenglin Wu, Ronghai Deng, Jiali Wang, Bowen Xu, Wenfang Chen, Shicong Yang, Changxi Wang
BACKGROUND: No study has validated, compared and adapted scoring systems for prognosis prediction based on donor kidney core biopsy (CB), with less glomeruli than wedge biopsy. METHODS: A total of 185 donor kidney CB specimens were reviewed using seven scoring systems. The association between the total score, item scores, score-based grading, and allograft prognosis was investigated. In specimens with less than ten glomeruli (88/185, 47.6%), scoring systems were modified by adjusting weights of the item scores...
December 2024: Renal Failure
https://read.qxmd.com/read/38337487/diabetic-kidney-disease-in-post-kidney-transplant-patients
#18
REVIEW
Ngoc-Yen T Pham, Diego Cruz, Luis Madera-Marin, Raja Ravender, Pablo Garcia
Post-transplant diabetes mellitus (PTDM) is a common occurrence in post-kidney transplantation and is associated with greater mortality, allograft failure, and increased risk of infections. The primary goal in the management of PTDM is to achieve glycemic control to minimize the risk of complications while balancing the need for immunosuppression to maintain the health of the transplanted kidney. This review summarizes the effects of maintenance immunosuppression and therapeutic options among kidney transplant recipients...
January 30, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38331047/genetic-versus-self-reported-african-ancestry-of-the-recipient-and-neighborhood-predictors-of-kidney-transplantation-outcomes-in-two-multiethnic-urban-cohorts
#19
JOURNAL ARTICLE
Francesca Zanoni, Y Dana Neugut, Joy E Obayemi, Lili Liu, Jun Y Zhang, Lloyd E Ratner, David J Cohen, Sumit Mohan, Ali G Gharavi, Brendan Keating, Krzysztof Kiryluk
African American (AA) kidney recipients have a higher risk of allograft rejection and failure compared to non-AAs, but to what extent these outcomes are due to genetic versus environmental effects is currently unknown. Herein, we tested the effects of recipient self-reported race versus genetic African admixture proportion (pAFR) and neighborhood socioeconomic status (SES) on kidney allograft outcomes in multiethnic kidney transplant recipients from Columbia University (N=1,083) and the University of Pennsylvania (N=738)...
February 6, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38326204/a-single-center-retrospective-study-of-re-transplantation-after-allograft-failure-in-kidney-transplant-recipients
#20
JOURNAL ARTICLE
Hiroshi Noguchi, Kyoko Miyamoto, Yuta Matsukuma, Kenji Ueki, Akihiro Tsuchimoto, Toshiaki Nakano, Akari Kaba, Yu Sato, Shinsuke Kubo, Keizo Kaku, Yasuhiro Okabe, Masafumi Nakamura
BACKGROUND: This study aimed to examine the outcomes of kidney retransplantation in patients with allograft failure at Kyushu University. METHODS: We reviewed data from 1043 consecutive patients (including 1001 in a first kidney transplantation [KT] group and 42 in a second KT group) who had undergone KT alone at our institution between January 2008 and September 2022. We also studied immunologic risks and outcomes of patients who had undergone preoperative testing for KT at Kyushu University during the same period...
February 6, 2024: Transplantation Proceedings
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