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https://www.readbyqxmd.com/read/29225568/age-dependent-subunit-specific-action-of-hydrogen-sulfide-on-glun1-2a-and-glun1-2b-nmda-receptors
#1
Aleksey V Yakovlev, Evgeniya D Kurmasheva, Yevheniia Ishchenko, Rashid Giniatullin, Guzel F Sitdikova
Hydrogen sulfide (H2S) is an endogenously produced neuroactive gas implicated in many key processes in the peripheral and central nervous system. Whereas the neuroprotective role of H2S has been shown in adult brain, the action of this messenger in newborns remains unclear. One of the known targets of H2S in the nervous system is the N-methyl-D-aspartate (NMDA) glutamate receptor which can be composed of different subunits with distinct functional properties. In the present study, using patch clamp technique, we compared the effects of the H2S donor sodium hydrosulfide (NaHS, 100 μM) on hippocampal NMDA receptor mediated currents in rats of the first and third postnatal weeks...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29225043/neurogranin-in-the-nucleus-accumbens-regulates-nmda-receptor-tolerance-and-motivation-for-ethanol-seeking
#2
Ashlie N Reker, Alfredo Oliveros, John M Sullivan, Lailun Nahar, David J Hinton, Taehyun Kim, Robert C Bruner, Doo-Sup Choi, Nicholas E Goeders, Hyung W Nam
Dysfunction of N-methyl-D-aspartate receptor (NMDAR) signaling in the nucleus accumbens (NAc) has been implicated in the pathophysiology of alcohol use disorders (AUD). Neurogranin (Ng), a calmodulin-binding protein, is exclusively expressed in the post-synapse, and mediates NMDAR driven synaptic plasticity by regulating the calcium-calmodulin (Ca2+-CaM) pathway. To study the functional role of Ng in AUD, we administrated behavior tests including Pavlovian instrument transfer (PIT), operant conditioning, and rotarod test using Ng null mice (Ng-/- mice)...
December 7, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29225041/syringaresinol-suppresses-excitatory-synaptic-transmission-and-picrotoxin-induced-epileptic-activity-in-the-hippocampus-through-presynaptic-mechanisms
#3
Young Seon Cho, Woo Seok Song, Sang Ho Yoon, Kyeong-Yeol Park, Myoung-Hwan Kim
Many neuromodulating drugs acting on the nervous system originate from botanical sources. These plant-derived substances modulate the activity of receptors, ion channels, or transporters in neurons. Their properties make the substances useful for medicine and research. Here, we show that the plant lignan (+)-syringaresinol (SYR) suppresses excitatory synaptic transmission via presynaptic modulation. Bath application of SYR rapidly reduced the slopes of the field excitatory postsynaptic potentials (fEPSPs) at the hippocampal Schaffer collateral (SC)-CA1 synapse in a dose-dependent manner...
December 7, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29222316/hla-donor-specific-antibodies-in-allogeneic-hematopoietic-stem-cell-transplantation-challenges-and-opportunities
#4
REVIEW
Douglas E Gladstone, Maria P Bettinotti
Allogenic hematopoietic stem cell recipients may have preformed antibodies directed against foreign HLA antigens. The use of partially HLA-mismatched allogeneic hematopoietic stem cell donors allows for the possibility of the presence of circulating HLA donor-specific antibodies (DSAs) in the recipient. The presence of DSAs at the time of stem cell infusion increases the risk of primary graft failure. More recently developed technology using solid phase immunoassays (SPIs) with fluorochrome-conjugated beads has greatly improved the ability to detect and classify DSAs...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29220053/the-mechanism-of-reduced-igg-ige-binding-of-%C3%AE-lactoglobulin-by-pulsed-electric-field-pretreatment-combined-with-glycation-revealed-by-ecd-fticr-ms
#5
Wenhua Yang, Zongcai Tu, Hui Wang, Lu Zhang, Igor A Kaltashov, Yunlong Zhao, Chendi Niu, Honglin Yao, Wenfeng Ye
Bovine β-lactoglobulin (β-Lg) is a major allergen existing in milk and causes about 90% of IgE-mediated cow's milk allergies. Previous studies showed that pulsed electric field (PEF) treatment could partially unfold the protein, which may contribute to the improvement of protein glycation. In this study, the effect of PEF pretreatment combined with glycation on the IgG/IgE-binding ability and the structure of β-Lg was investigated. The result showed that PEF pretreatment combined with glycation significantly reduced the IgG and IgE binding abilities, which was attributed to the changes of secondary and tertiary structure and the increase in glycation sites and degree of substitution per peptide (DSP) value determined by electron capture dissociation Fourier transform ion cyclotron resonance mass spectrometry (ECD/FTICR-MS)...
December 8, 2017: Food & Function
https://www.readbyqxmd.com/read/29218906/addressing-vital-sign-alarm-fatigue-using-personalized-alarm-thresholds
#6
Sarah Poole, Nigam Shah
Alarm fatigue, a condition in which clinical staff become desensitized to alarms due to the high frequency of unnecessary alarms, is a major patient safety concern. Alarm fatigue is particularly prevalent in the pediatric setting, due to the high level of variation in vital signs with patient age. Existing studies have shown that the current default pediatric vital sign alarm thresholds are inappropriate, and lead to a larger than necessary alarm load. This study leverages a large database containing over 190 patient-years of heart rate data to accurately identify the 1st and 99th percentiles of an individual's heart rate on their first day of vital sign monitoring...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29218644/cardiovascular-complications-of-marijuana-and-related-substances-a-review
#7
REVIEW
Amitoj Singh, Sajeev Saluja, Akshat Kumar, Sahil Agrawal, Munveer Thind, Sudip Nanda, Jamshid Shirani
The recreational use of cannabis has sharply increased in recent years in parallel with its legalization and decriminalization in several countries. Commonly, the traditional cannabis has been replaced by potent synthetic cannabinoids and cannabimimetics in various forms. Despite overwhelming public perception of the safety of these substances, an increasing number of serious cardiovascular adverse events have been reported in temporal relation to recreational cannabis use. These have included sudden cardiac death, vascular (coronary, cerebral and peripheral) events, arrhythmias and stress cardiomyopathy among others...
December 7, 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/29216889/targeting-the-cross-talk-between-urokinase-receptor-and-formyl-peptide-receptor-type-1-to-prevent-invasion-and-trans-endothelial-migration-of-melanoma-cells
#8
Concetta Ragone, Michele Minopoli, Vincenzo Ingangi, Giovanni Botti, Federica Fratangelo, Antonello Pessi, Maria Patrizia Stoppelli, Paolo Antonio Ascierto, Gennaro Ciliberto, Maria Letizia Motti, Maria Vincenza Carriero
BACKGROUND: Accumulating evidence demonstrates that the Urokinase Receptor (uPAR) regulates tumor cell migration through its assembly in composite regulatory units with transmembrane receptors, and uPAR88-92 is the minimal sequence required to induce cell motility through the Formyl Peptide Receptor type 1 (FPR1). Both uPAR and FPR1 are involved in melanoma tumor progression, suggesting that they may be targeted for therapeutic purposes. In this study, the role of the uPAR-FPR1 cross-talk to sustain melanoma cell ability to invade extracellular matrix and cross endothelial barriers is investigated...
December 8, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29216784/evaluation-of-peripheral-serotonin-content-and-%C3%AE-2-adrenergic-receptor-function-as-potential-markers-for-life-long-recurrent-depressive-disorder-by-using-methodological-improvements
#9
Boris Aleksovski, Antoni Novotni, Viktorija Vujović, Vladimir Rendevski, Nensi Manusheva, Violeta Neceva, Ana Filipce, Aleksandar Risteski, Vasko Aleksovski, Icko Gjorgoski
OBJECTIVE: We aimed to evaluate the role and the relations between peripheral platelet serotonin content, blood plasma serotonin concentration and the function of platelet α2-adrenergic receptors (α2-AR) as potential state or trait biomarkers for recurrent depressive disorder (RDD). METHODS: 26 drug-free patients with life-long RDD and 31 healthy controls were included in the study. Several methodological improvements in blood collection and platelet isolation were implemented following the present standards in Haematology and Light transmission aggregometry...
December 7, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/29215686/are-desensitizing-toothpastes-equally-biocompatible-and-effective-against-microorganisms
#10
Samira Esteves Afonso Camargo, Noala Vicensoto Moreira Milhan, Fernanda de Oliveira Saraiva, Jonatas Rafael de Oliveira, Luciane Dias de Oliveira, Carlos Henrique Ribeiro Camargo
The aims of this study were evaluate cytotoxicity, genotoxicity, antimicrobial activity of desensitizing toothpastes compared to a common one and the surface roughness of tooth enamel submitted to brushing with these toothpastes. Samples of three desensitizing toothpastes (Colgate Sensitive, Sensodyne and Oral B Sensitive) and common toothpaste (Colgate) were placed in contact with gingival human fibroblasts. Cytotoxicity and genotoxocity were measured by MTT assay and micronucleus test. Antimicrobial activity of the toothpastes extracts against C...
September 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29213253/the-role-of-slow-wave-sleep-in-memory-pathophysiology-focus-on-post-traumatic-stress-disorder-and-eye-movement-desensitization-and-reprocessing
#11
Sara Carletto, Thomas Borsato, Marco Pagani
No abstract text is available yet for this article.
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29209071/inhaled-nicotine-equivalent-to-cigarette-smoking-disrupts-systemic-and-uterine-hemodynamics-and-induces-cardiac-arrhythmia-in-pregnant-rats
#12
Xuesi M Shao, Héctor E López-Valdés, Jing Liang, Jack L Feldman
Maternal smoking with obligatory nicotine inhalation is associated with preterm delivery, low birth weight, fetal growth retardation and developmental defects. We tested the hypothesis that cigarette smoking-relevant nicotine inhalation during pregnancy impairs cardiovascular function and uterine hemodynamics with consequential fetal ischemia. Pregnant rats exposed to episodic inhaled nicotine via a novel lung alveolar region-targeted aerosol method produced nicotine pharmacokinetics resembling cigarette smoking in humans...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29207227/first-case-report-of-using-ofatumumab-in-kidney-transplantation-ab0-incompatible
#13
Nicoletta Mancianti, Giulio Monaci, Fabio Rollo, Paola Buracchi, Andrea Guarnieri, Marina Di Luca, Mauro Martello, Guido Garosi
Modern methods for desensitization protocol rely heavily on combined apheresis therapy and Rituximab, a chimeric (murine and human) anti-CD20 antibody used in AB0 incompatible kidney transplants. Severe infusion related reactions due to the administration of Rituximab are reported in 10% of patients. These adverse reactions may hinder the completion of the desensitization protocol. Therefore, it's useful to test alternative B cell depleting therapies. Our clinical case focuses on a 41-year-old male who developed an adverse infusion reaction following the administration of Rituximab and was given Ofatumumab as an alternative treatment...
December 5, 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29205393/eaaci-guidelines-on-allergen-immunotherapy-ige-mediated-food-allergy
#14
G B Pajno, M Fernandez-Rivas, S Arasi, G Roberts, C A Akdis, M Alvaro-Lozano, K Beyer, C Bindslev-Jensen, W Burks, M Ebisawa, P Eigenmann, E Knol, K C Nadeau, L K Poulsen, R van Ree, A F Santos, G du Toit, S Dhami, U Nurmatov, Y Boloh, M Makela, L O'Mahony, N Papadopoulos, C Sackesen, I Agache, E Angier, S Halken, M Jutel, S Lau, O Pfaar, D Ryan, G Sturm, E-M Varga, R G van Wijk, A Sheikh, A Muraro
Food allergy can result in considerable morbidity, impairment of quality of life, and healthcare expenditure. There is therefore interest in novel strategies for its treatment, particularly food allergen immunotherapy (FA-AIT) through the oral (OIT), sublingual (SLIT), or epicutaneous (EPIT) routes. This Guideline, prepared by the European Academy of Allergy and Clinical Immunology (EAACI) Task Force on Allergen Immunotherapy for IgE-mediated Food Allergy, aims to provide evidence-based recommendations for active treatment of IgE-mediated food allergy with FA-AIT...
September 27, 2017: Allergy
https://www.readbyqxmd.com/read/29203613/nfe2l1-silenced-insulinoma-cells-acquire-aggressiveness-and-chemo-resistance
#15
Jingqi Fu, Hongzhi Zheng, Qi Cui, Chengjie Chen, Simeng Bao, Jing Sun, Lu Li, Bei Yang, Huihui Wang, Yongyong Hou, Yuanyuan Xu, Yuanhong Xu, Qiang Zhang, Jingbo Pi
The transcription factor nuclear factor erythroid 2 like 1 (NFE2L1 or NRF1) is involved in various critical cell processes such as maintenance of ubiquitin-proteasome system and regulation of the cellular antioxidant response. We previously determined that pancreatic β-cell-specific Nfe2l1-knockout mice had hyperinsulinemia, and that silencing of Nfe2l1 in mouse islets or MIN6 insulinoma β-cells induced elevated basal insulin release and altered glucose metabolism. Hypoglycemia is a major issue with aggressive insulinomas, although a role of NFE2L1 in this pathology is not defined...
December 4, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29203586/cooh-terminal-saa1-peptides-fail-to-induce-chemokines-but-synergize-with-cxcl8-and-ccl3-to-recruit-leukocytes-via-fpr2
#16
Mieke De Buck, Mieke Gouwy, Nele Berghmans, Ghislain Opdenakker, Paul Proost, Sofie Struyf, Jo Van Damme
A natural leukocyte chemoattractant was isolated from bovine serum by an established four-step purification procedure. Based on its relative molecular mass of 7287 and NH2-terminal sequence, the protein was identified as a carboxy-terminal peptide of the acute phase protein serum amyloid A (SAA) 1. This SAA1(46-112) fragment and its human equivalent SAA1(47-104) were chemically synthesized. Unlike intact SAA1α, these SAA fragments failed to directly chemoattract neutrophils and monocytes, to induce chemokines and to stimulate downstream ERK signaling in monocytes...
December 4, 2017: Blood
https://www.readbyqxmd.com/read/29203298/the-genetic-and-molecular-bases-for-hypertrophic-cardiomyopathy-the-role-for-calcium-sensitization
#17
REVIEW
Xianfeng Ren, Nadia Hensley, Mary Beth Brady, Wei Dong Gao
Hypertrophic cardiomyopathy (HCM) affects millions of people around the world as one of the most common genetic heart disorders and leads to cardiac ischemia, heart failure, dysfunction of other organ systems, and increased risk for sudden unexpected cardiac deaths. HCM can be caused by single-point mutations, insertion or deletion mutations, or truncation of cardiac myofilament proteins. The molecular mechanism that leads to disease progression and presentation is still poorly understood, despite decades of investigations...
May 19, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29202594/diagnosing-and-managing-patients-with-drug-hypersensitivity
#18
Javier Fernandez, Inmaculada Doña
Diagnosing and managing drug hypersensitivity is challenging because there are no clear limits between different types of drug reactions. Distinguishing between type A (predictable) and type B (hypersensitivity) reactions when a drug is introduced on the market is not easy. When many people use a drug, adverse reactions can occur, conditioned by diverse genetic profiles, viral infections or concomitant therapy. Occasionally the only tool clinicians have on which to base the diagnosis is the clinical history...
December 4, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29199560/lion-s-mane-medicinal-mushroom-hericium-erinaceus-agaricomycetes-modulates-purinoceptor-coupled-calcium-signaling-and-murine-nociceptive-behavior
#19
Pei-Shan Liu, Sheau-Huei Chueh, Chin-Chu Chen, Li-Ya Lee, Li-Yen Shiu
Hericium erinaceus is well known for the neurotrophic effect it confers by promoting nerve growth factor biosynthesis. We discovered a novel bioactivity of H. erinaceus in its ability to suppress adenosine triphosphate (ATP)-induced calcium signaling in neuronal PC12 cells. ATP, known primarily as a neurotransmitter, also acts on purinoceptors (P2 purinergic receptor [P2R]) to generate the cellular calcium signaling and secretion that mediate P2R physiological manifestations, including pain. Chronic pain reduces quality of life...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29199005/ginsenoside-rg3-sensitizes-hypoxic-lung-cancer-cells-to-cisplatin-via-blocking-of-nf-%C3%AE%C2%BAb-mediated-epithelial-mesenchymal-transition-and-stemness
#20
Jingjing Wang, Lili Tian, Muhammad Noman Khan, Li Zhang, Qun Chen, Yi Zhao, Qiu Yan, Li Fu, Jiwei Liu
Cisplatin is a first line chemotherapy in lung cancer, but decreased susceptibility may limit its application. In solid tumors, hypoxia alters the microenvironment and is associated with proliferation, metastasis, and drug sensitivity. The hypoxia-induced desensitization of cisplatin is not clearly elucidated. 20 (R)-Ginsenoside (Rg3), the traditional Chinese medicine, is extracted from ginseng and has antitumor activities. In this study, we evaluated if Rg3 is effective in improving cisplatin sensitivity by blocking hypoxia...
November 30, 2017: Cancer Letters
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