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desensitization

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https://www.readbyqxmd.com/read/28087382/efficacy-and-safety-of-high-dose-rush-oral-immunotherapy-in-persistent-egg-allergic-children-a-randomized-clinical-trial
#1
Inmaculada Pérez-Rangel, Pablo Rodríguez Del Río, Carmelo Escudero, Silvia Sánchez-García, José Javier Sánchez-Hernández, María Dolores Ibáñez
BACKGROUND: Egg oral immunotherapy is effective but time consuming. OBJECTIVE: To assess the efficacy and safety of egg rush oral immunotherapy (ROIT) with a targeted dose equivalent to a raw egg white. METHODS: Thirty-three persistent egg allergic children confirmed by double-blind, placebo-controlled food challenge (DBPCFC) were randomized to receive egg ROIT immediately after randomization (ROIT1 group), or to continue an egg avoidance diet for 5 months after randomization (control group [CG])...
January 10, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28086979/b-cell-repertoires-in-hla-sensitized-kidney-transplant-candidates-undergoing-desensitization-therapy
#2
John F Beausang, H Christina Fan, Rene Sit, Maria U Hutchins, Kshama Jirage, Rachael Curtis, Edward Hutchins, Stephen R Quake, Julie M Yabu
BACKGROUND: Kidney transplantation is the most effective treatment for end-stage renal disease. Sensitization refers to pre-existing antibodies against human leukocyte antigen (HLA) protein and remains a major barrier to successful transplantation. Despite implementation of desensitization strategies, many candidates fail to respond. Our objective was to determine whether measuring B cell repertoires could differentiate candidates that respond to desensitization therapy. METHODS: We developed an assay based on high-throughput DNA sequencing of the variable domain of the heavy chain of immunoglobulin genes to measure changes in B cell repertoires in 19 highly HLA-sensitized kidney transplant candidates undergoing desensitization and 7 controls with low to moderate HLA sensitization levels...
January 13, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28086862/management-of-dentin-hypersensitivity-by-national-dental-practice-based-research-network-practitioners-results-from-a-questionnaire-administered-prior-to-initiation-of-a-clinical-study-on-this-topic
#3
Dorota T Kopycka-Kedzierawski, Cyril Meyerowitz, Mark S Litaker, Sidney Chonowski, Marc W Heft, Valeria V Gordan, Robin L Yardic, Theresa E Madden, Stephanie C Reyes, Gregg H Gilbert
BACKGROUND: Dentin hypersensitivity (DH) is a common problem encountered in clinical practice. The purpose of this study was to identify the management approaches for DH among United States dentists. METHODS: One hundred eighty five National Dental Practice-Based Research Network clinicians completed a questionnaire regarding their preferred methods to diagnose and manage DH in the practice setting, and their beliefs about DH predisposing factors. RESULTS: Almost all dentists (99%) reported using more than one method to diagnose DH...
January 13, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28076496/evaluation-of-dentin-hypersensitivity-treatment-with-glass-ionomer-cements-a-randomized-clinical-trial
#4
Marina de Matos Madruga, Adriana Fernandes da Silva, Wellington Luiz de Oliveira da Rosa, Evandro Piva, Rafael Guerra Lund
A randomized, double-blind, split-mouth clinical trial was performed compared the desensitizing efficacy of the resin-modified glass ionomer cement (GIC) ClinproTM XT (3M ESPE, Minnesota, USA) and the conventional GIC Vidrion R (SS White, Gloucester, UK) in a 6-month follow-up. Subjects were required to have at least two teeth with dentin hypersensitivity. Teeth were divided at random into 2 groups, one group received Clinpro XT and the other conventional GIC Vidrion R. Treatments were assessed by tactile and air blast tests using Visual Analogue Scale (VAS) at baseline, after 20 minutes, and at 7, 15, 21, 30, 90 and 180 days post-treatment...
January 5, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28075392/a-distance-detector-with-a-strip-magnetic-mosfet-and-readout-circuit
#5
Guo-Ming Sung, Wen-Sheng Lin, Hsing-Kuang Wang
This paper presents a distance detector composed of two separated metal-oxide semiconductor field-effect transistors (MOSFETs), a differential polysilicon cross-shaped Hall plate (CSHP), and a readout circuit. The distance detector was fabricated using 0.18 μm 1P6M Complementary Metal-Oxide Semiconductor (CMOS) technology to sense the magnetic induction perpendicular to the chip surface. The differential polysilicon CSHP enabled the magnetic device to not only increase the magnetosensitivity but also eliminate the offset voltage generated because of device mismatch and Lorentz force...
January 10, 2017: Sensors
https://www.readbyqxmd.com/read/28070618/blunted-5-ht1a-receptor-mediated-responses-and-antidepressant-like-behavior-in-mice-lacking-the-gabab1a-but-not-gabab1b-subunit-isoforms
#6
Laura H Jacobson, Daniel Hoyer, Dominique Fehlmann, Bernhard Bettler, Klemens Kaupmann, John F Cryan
RATIONALE: There is accumulating evidence for a role of GABAB receptors in depression. GABAB receptors are heterodimers of GABAB1 and GABAB2 receptor subunits. The predominant GABAB1 subunit isoforms are GABAB1a and GABAB1b. GABAB1 isoforms in mice differentially influence cognition, conditioned fear, and susceptibility to stress, yet their influence in tests of antidepressant-like activity has not been fully investigated. OBJECTIVES: Given the interactions between GABAB receptors and the serotonergic system and the involvement of 5-HT1A receptors (5-HT1AR) in antidepressant action, we sought to evaluate 5-HT1AR function in GABAB1a(-/-) and GABAB1b(-/-) mice...
January 9, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28069404/calculated-panel-reactive-antibody-with-decimals-a-refined-metric-of-access-to-transplantation-for-highly-sensitized-candidates
#7
Evan P Kransdorf, Marcelo J Pando
The use of the calculated panel reactive antibody (CPRA) value and the implementation of allocation points for sensitized candidates by the United Network for Organ Sharing (UNOS) have improved access to kidney transplantation for highly sensitized candidates (98% CPRA and above). Despite this, a large population of highly sensitized candidates remain awaiting transplantation. To better define this population, we propose the use of two refinements of the standard UNOS CPRA, the CPRA with decimals or CPRAd, and the likelihood of a compatible donor (LCD)...
January 6, 2017: Human Immunology
https://www.readbyqxmd.com/read/28065801/frequency-and-severity-of-reactions-to-a-325-mg-aspirin-dose-during-desensitization
#8
Charles F Schuler, James L Baldwin, Alan P Baptist
BACKGROUND: The frequency with which patients with aspirin-exacerbated respiratory disease (AERD) react to 325 mg of aspirin during aspirin desensitization, or fail to react at all, is not fully known. OBJECTIVE: To determine the rate and type of reaction at 325 mg of aspirin during desensitization. METHODS: A retrospective study of 104 patients who underwent aspirin desensitization from 2010 to 2016 was performed. A standard desensitization protocol (starting at 20-40 mg, progressing through 325 mg, and extinguishing reactions by dose repetition) was used...
January 5, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28063043/subcutaneous-and-sublingual-immunotherapy-in-a-mouse-model-of-allergic-asthma
#9
Laura Hesse, Martijn C Nawijn
Allergic asthma, caused by inhaled allergens such as house dust mite or grass pollen, is characterized by reversible airway obstruction, associated with an eosinophilic inflammation of the airways, as well as airway hyper responsiveness and remodeling. The inhaled allergens trigger a type-2 inflammatory response with involvement of innate lymphoid cells (ILC2) and Th2 cells, resulting in high production of immunoglobulin E (IgE) antibodies. Consequently, renewed allergen exposure results in a classic allergic response with a distinct early and late phase, both resulting in bronchoconstriction and shortness of breath...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28062183/%C3%AE-arrestin-is-critical-for-early-shear-stress-induced-akt-enos-activation-in-human-vascular-endothelial-cells
#10
Ana Paula Carneiro, Miriam Helena Fonseca-Alaniz, Luís Alberto Oliveira Dallan, Ayumi Aurea Miyakawa, Jose Eduardo Krieger
Recent evidence suggests that β-arrestins, which are involved in G protein-coupled receptors desensitization, may influence mechanotransduction. Here, we observed that nitric oxide (NO) production was abrogated in human saphenous vein endothelial cells (SVECs) transfected with siRNA against β-arrestin 1 and 2 subjected to shear stress (SS, 15 dynes/cm(2), 10 min). The downregulation of β-arrestins 1/2 in SVECs cells also prevented the SS-induced rise in levels of phosphorylation of Akt and endothelial nitric oxide synthase (eNOS, Serine 1177)...
January 3, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28058751/allergen-immunotherapy-for-ige-mediated-food-allergy-a-systematic-review-and-meta-analysis
#11
REVIEW
Ulugbek Nurmatov, Sangeeta Dhami, Stefania Arasi, Giovanni Battista Pajno, Montserrat Fernandez-Rivas, Antonella Muraro, Graham Roberts, Cezmi Akdis, Montserrat Alvaro-Lozano, Kirsten Beyer, Carsten Bindslev-Jensen, Wesley Burks, George du Toit, Motohiro Ebisawa, Philippe Eigenmann, Edward Knol, Mika Makela, Kari Christine Nadeau, Liam O'Mahony, Nikolaos Papadopoulos, Lars K Poulsen, Cansin Sackesen, Hugh Sampson, Alexandra Santos, Ronald van Ree, Frans Timmermans, Aziz Sheikh
BACKGROUND: The European Academy of Allergy and Clinical Immunology (EAACI) is developing Guidelines for Allergen Immunotherapy (AIT) for IgE-mediated Food Allergy. To inform the development of clinical recommendations, we sought to critically assess evidence on the effectiveness, safety and cost-effectiveness of AIT in the management of food allergy. METHODS: We undertook a systematic review and meta-analysis that involved searching nine international electronic databases for randomized controlled trials (RCTs) and non-randomized studies (NRS)...
January 6, 2017: Allergy
https://www.readbyqxmd.com/read/28058453/early-history-of-the-breeding-of-amino-acid-producing-strains
#12
Shigeru Nakamori
Amino acid production started in Japan in 1908 with the extraction of monosodium glutamate (MSG) from acid hydrolysates of proteins. In addition to extraction, other methods of amino acid production include chemical synthesis, fermentation, and enzymatic synthesis both for glutamic acid and other amino acids. In this chapter, we review the historical transition of these production methods; currently, fermentation is the chief production method of amino acids. All wild-type microorganisms possess a negative feedback control system (feedback inhibition and repression) on the enzymes within the amino acid biosynthetic pathways...
January 6, 2017: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/28053034/simultaneous-loss-of-nckx4-and-cng-channel-desensitization-impairs-olfactory-sensitivity
#13
Christopher H Ferguson, Haiqing Zhao
: In vertebrate olfactory sensory neurons (OSNs), Ca(2+) plays key roles in both mediating and regulating the olfactory response. Ca(2+) enters OSN cilia during the response through the olfactory cyclic nucleotide-gated (CNG) channel and stimulates a depolarizing chloride current by opening the olfactory Ca(2+)-activated chloride channel to amplify the response. Ca(2+) also exerts negative regulation on the olfactory transduction cascade, through mechanisms that include reducing the CNG current by desensitizing the CNG channel via Ca(2+)/calmodulin (CaM), to reduce the response...
January 4, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28052368/synthesis-and-activity-of-the-salicylic-acid-ester-of-bakuchiol-in-psoriasis-surrogate-keratinocytes-and-skin-substitutes
#14
S Ma, K Gobis, W R Swindell, R Chaudhuri, R Bojanowski, K Bojanowski
BACKGROUND: Topical retinoids are effective in retarding skin ageing and restoring homeostasis in skin conditions such as psoriasis. However their adverse effects (AEs), which include irritation (retinoid dermatitis), photosensitivity and teratogenicity, limit their use and patient compliance. Development of retinoid analogues with minimal AEs would allow a broader and more compliant use. AIM: To synthesise a novel molecule, bakuchiol salicylate (bakusylan), with a modulatory gene expression profile similar to retinoids, using as reference three prescription retinoids: tretinoin, tazarotene and adapalene...
January 4, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28051968/reliability-and-feasibility-considerations-in-the-assessment-of-a-malodor-adaptation-technique-a-pilot-study
#15
William Y Pike, Michael D Proctor, Deborah N Burgess
Research often links barriers to optimal human performance of a complex medical task to malodor exposure. Olfactory adaptation, or desensitization to an odorant, may ameliorate performance degradation. Olfactory adaptation is traditionally measured by detection threshold and perceived intensity. Nontraditional measures including stress, confusion, and escape behavior may better reflect impacts on performance but face validity concerns. This article describes a pilot study undertaken to determine what measurements and techniques are best suited and logistically feasible to explore olfactory adaptation with respect to performance of a relevant task...
January 2017: Military Medicine
https://www.readbyqxmd.com/read/28049204/rapid-drug-desensitization-with-biologics-a-single-center-experience-with-four-biologics
#16
Sevim Bavbek, Reşat Kendirlinan, Pamir Çerçi, Seda Altıner, Şadan Soyyiğit, Zeynep Çelebi Sözener, Ömür Aydın, Reyhan Gümüşburun
BACKGROUND: Rapid drug desensitization (RDD) induces a temporary tolerance to biologics which induce hypersensitivity reactions (HSRs). Data are limited regarding the use of RDD outside the USA. Our purpose was to report our data on RDD to rituximab, infliximab, cetuximab, and trastuzumab. METHODS: The study was conducted as a retrospective chart review of patients with symptoms of HSRs to biologics. HSRs were classified as grades I, II, and III, based on their severity...
January 4, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28048086/su-f-t-120-how-many-and-which-respiratory-phases-should-be-included-during-the-4d-robust-optimization-process
#17
S Ge, X Wang, R Mohan
PURPOSE: To study how many and which respiratory phases should be included to conduct an efficient 4D robust optimization since contouring CTV and critical organs at all 10 phases are time consuming. METHODS: A 4D robust optimization algorithm which simultaneously optimizes dose distributions for all 10 respiratory phases has been developed to desensitize plan quality to various uncertainties. To study the possibility of reducing number of phases included during the optimization process while keep the plan quality, four strategies have been conducted and compared: A...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045854/the-percentage-of-amplitude-decrease-warning-criteria-for-transcranial-mep-monitoring
#18
Henricus L Journée, Hanneke I Berends, Moyo C Kruyt
Muscle motor evoked potentials (MEPs) from transcranial electrical stimulation (TES) became a standard technique for monitoring the motor functions of the brain and spinal cord at risk during spinal and brain surgery. However, a wide range of criteria based on the percentage of amplitude decrease is used in practice. A survey of the current literature on clinical outcome parameters reveals a variety of percentages in a range of 30% to 100% (50% to 100% spinal procedures) with no consensus. The interpretation of muscle MEPs is hampered by their sensitivity to many interfering factors...
January 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/28045487/probing-the-allosteric-role-of-the-%C3%AE-5-subunit-of-%C3%AE-3%C3%AE-4%C3%AE-5-nicotinic-acetylcholine-receptors-by-functionally-selective-modulators-and-ligands
#19
Caroline Ray, Erik J Soderblom, Yushi Bai, F Ivy Carroll, Marc G Caron, Larry S Barak
Nicotinic acetylcholine receptors regulate the nicotine dependence encountered with cigarette smoking, and this has stimulated a search for drugs binding the responsible receptor subtypes. Studies link a gene cluster encoding for α3β4α5-D398N nicotinic acetylcholine receptors to lung cancer risk as well as link a second mutation in this cluster to an increased risk for nicotine dependence. However, there are currently no recognized drugs for discriminating α3β4α5 signaling. In this study we describe the development of homogenous HEK-293 cell clones of α3β4 and α3β4α5 receptors appropriate for drug screening and characterizing biochemical and pharmacological properties of incorporated α5 subunits...
January 3, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28042528/desensitization-for-peanut-allergies-in-children
#20
Rekha D Jhamnani, Pamela Frischmeyer-Guerrerio
Immunotherapy for peanut allergy has been an exploding topic of study within the last few years. Sublingual, epicutaneous, and oral immunotherapy are being investigated and show promise in the treatment of peanut allergy. Oral immunotherapy has shown the most clinical benefit; however, sublingual and epicutaneous immunotherapy appear to have the most favorable safety profiles. Most studies to date suggest that only a minority of subjects achieve sustained unresponsiveness to peanut after discontinuation of immunotherapy...
September 2016: Current Treatment Options in Allergy
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