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https://www.readbyqxmd.com/read/29457640/application-of-adaptive-laboratory-evolution-to-overcome-a-flux-limitation-in-an-escherichia-coli-production-strain
#1
Kento Tokuyama, Yoshihiro Toya, Takaaki Horinouchi, Chikara Furusawa, Fumio Matsuda, Hiroshi Shimizu
Gene deletion strategies using flux balance analysis (FBA) have improved the growth-coupled production of various compounds. However, the productivities were often below the expectation because the cells failed to adapt to these genetic perturbations. Here, we demonstrate the productivity of the succinate of the designed gene deletion strain was improved by adaptive laboratory evolution (ALE). Although FBA predicted deletions of adhE-pykAF-gldA-pflB lead to produce succinate from glycerol with a yield of 0...
February 19, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29455573/a-creb-mediated-increase-in-mirna-let-7f-during-prolonged-%C3%AE-agonist-exposure-a-novel-mechanism-of-%C3%AE-2-adrenergic-receptor-down-regulation-in-airway-smooth-muscle
#2
Donghwa Kim, Soomin Cho, Jung A Woo, Stephen B Liggett
β2 -Adrenergic receptors (β2 ARs) desensitize during continuous agonist activation, which manifests clinically as tachyphylaxis. β-Agonist desensitization of β2 ARs in human airway smooth muscle (HASM) cells is recognized in the treatment of asthma and may be related to poor outcomes. Rapid events in desensitization include receptor phosphorylation and internalization, but mechanisms responsible for the decrease in receptor protein after prolonged agonist exposure (down-regulation) are ill defined. The microRNA (miRNA) let-7f regulates β2 AR expression by translational repression...
February 13, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29455306/dentinal-tubule-sealing-effects-of-532-nm-diode-pumped-solid-state-laser-gallic-acid-fe-3-complex-and-three-commercial-dentin-desensitizers
#3
Soram Oh, Yu Gu, Hiran Perinpanayagam, Yeon-Jee Yoo, Yoon Lee, Ryun Kyung Kim, Seok Woo Chang, Jongho Lee, Qiang Zhu, Kee Yeon Kum
The purpose of this study was to compare dentinal tubule sealing effects of a 532-nm diode-pumped solid-state (DPSS) laser, gallic acid/Fe3+ complex, and three commercially available dentin desensitizers. Human premolars (n = 44) extracted for orthodontics had standardized cervical cavities prepared, etched (37% phosphoric acid) and randomly assigned to either a control (n = 4), or one of five treatment groups (n = 8/group). Desensitizing treatments were either a 532-nm DPSS laser, gallic acid/Fe3+ complex, oxalate-based Super Seal™ (SS), DIO™ Enamel Coating Pen Pro Tooth (Dio), or adhesive-type Hybrid Coat™ (HC)...
February 17, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29452208/outcome-of-abo-incompatible-adult-living-donor-liver-transplantation-for-patients-with-hepatocellular-carcinoma
#4
Young-In Yoon, Gi-Won Song, Sung-Gyu Lee, Shin Hwang, Ki-Hun Kim, Seok-Hwan Kim, Woo-Hyoung Kang, Hwui-Dong Cho, Eun-Kyoung Jwa, Jae-Hyun Kwon, Eun-Young Tak, Varvara A Kirchner
BACKGROUND & AIMS: Living-donor liver transplantation (LDLT) can simultaneously cure hepatocellular carcinoma (HCC) and underlying liver cirrhosis, improving long-term results in patients with HCC. ABO-incompatible LDLT could expand the living-donor pool, reduce waiting times for deceased-donor liver transplantation, and improve long-term survival for some patients with HCC. METHODS: We retrospectively reviewed the medical records of patients undergoing LDLT for HCC from November 2008 to December 2015 at a single institution in Korea...
February 13, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29451400/designing-selective-modulators-for-the-nicotinic-receptor-subtypes-challenges-and-opportunities
#5
Dina Manetti, Cristina Bellucci, Niccolò Chiaramonte, Silvia Dei, Elisabetta Teodori, Maria Novella Romanelli
Nicotinic receptors are membrane proteins involved in several physiological processes. They are considered suitable drug targets for various CNS disorders or conditions, as shown by the large number of compounds which have entered clinical trials. In recent years, nonconventional agonists have been discovered: positive allosteric modulators, allosteric agonists, site-specific agonists and silent desensitizers are compounds able to modulate the receptor interacting at sites different from the orthodox one, or to desensitize the receptor without prior opening...
February 16, 2018: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29448114/safe-and-effective-intradermal-influenza-vaccine-desensitization-for-delayed-influenza-vaccine-allergy
#6
Tsuzumi Kanaoka, Kazune Matsuoka, Marcus Shaker
No abstract text is available yet for this article.
February 12, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29447656/local-heat-urticaria
#7
Forrest White, Gabriela Cobos, Nicholas A Soter
We present a 38-year-old woman with local heat urticaria confirmed by heat provocation testing. Heat urticaria is a rare form of physical urticaria that istriggered by exposure to a heat source, such as hot water or sunlight. Although it is commonly localized and immediate, generalized and delayed onset forms exist. Treatment options include antihistamines and heat desensitization. A brisk, mechanical stroke elicited a linear wheal. Five minutes after exposure to hot water, she developed well-demarcated,erythematous blanching wheals that covered the distal forearm and entire hand...
December 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29445200/impaired-%C3%AE-arrestin-recruitment-and-reduced-desensitization-by-non-catechol-agonists-of-the-d1-dopamine-receptor
#8
David L Gray, John A Allen, Scot Mente, Rebecca E O'Connor, George J DeMarco, Ivan Efremov, Patrick Tierney, Dmitri Volfson, Jennifer Davoren, Edward Guilmette, Michelle Salafia, Rouba Kozak, Michael D Ehlers
Selective activation of dopamine D1 receptors (D1Rs) has been pursued for 40 years as a therapeutic strategy for neurologic and psychiatric diseases due to the fundamental role of D1Rs in motor function, reward processing, and cognition. All known D1R-selective agonists are catechols, which are rapidly metabolized and desensitize the D1R after prolonged exposure, reducing agonist response. As such, drug-like selective D1R agonists have remained elusive. Here we report a novel series of selective, potent non-catechol D1R agonists with promising in vivo pharmacokinetic properties...
February 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29442087/the-effect-of-three-desensitizing-agents-on-dentin-hypersensitivity-a-randomized-split-mouth-clinical-trial
#9
Periasamy Ravishankar, Venkatnagaraj Viswanath, Durvasulu Archana, Venkatesan Keerthi, Saranya Dhanapal, Kalambur Perumal Lavanya Priya
Objectives: This randomized clinical trial tested the effect of three different desensitizing agents on reduction of pain due to hypersensitive cervical dentin lesions. Materials and Methods: Twenty-eight individuals with 84 teeth diagnosed with cervical dentin hypersensitivity (DH) in at least one tooth in any three of the four quadrants were selected. Patients exhibiting pain scores of two or more on the visual analog scale (VAS) were included in the study. Each quadrant in an individual was randomly assigned to one of the three treatment groups based on computer-generated random number...
January 2018: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/29440552/a-missense-mutation-a384p-associated-with-human-hyperekplexia-reveals-a-desensitization-site-of-glycine-receptors
#10
Chen-Hung Wang, Ciria C Hernandez, Junyi Wu, Ning Zhou, Hsin-Yu Hsu, Mei-Lin Shen, Yi-Ching Wang, Robert L Macdonald, Dong Chuan Wu
Hyperekplexia, an inherited neuronal disorder characterized by exaggerated startle responses with unexpected sensory stimuli, is caused by dysfunction of glycinergic inhibitory transmission. From analysis of newly identified human hyperekplexia mutations in the glycine receptor (GlyR) α1 subunit, we found that an alanine-to-proline missense mutation (A384P) resulted in substantially higher desensitization level and lower agonist sensitivity of homomeric α1 GlyRs when expressed in HEK cells. The incorporation of the β subunit fully reversed the reduction in agonist sensitivity and partially reversed the desensitization of α1 A384P The heteromeric α1 A384P β GlyRs showed enhanced desensitization but unchanged agonists-induced maximum responses, surface expression, main channel conductance, and voltage-dependence compared with that of the wild-type α1β (α1 WT β) GlyRs...
February 13, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29439935/successful-subcutaneous-desensitization-in-a-patient-with-allergy-to-ixekizumab
#11
Ruth Barranco Jimenez, Daiana Guillen Vera, Raquel Rivera-Díaz, Susana Cortijo-Cascajares, Ruth Mielgo Ballesteros, María Del Carmen Diéguez Pastor
No abstract text is available yet for this article.
February 10, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29439773/effect-of-an-experimental-desensitizing-agent-on-reduction-of-bleaching-induced-tooth-sensitivity-a-triple-blind-randomized-clinical-trial
#12
Sibelli Olivieri Parreiras, Anna Luiza Szesz, Fabiana Madalozzo Coppla, Eveline Claudia Martini, Paulo Vitor Farago, Alessandro D Loguercio, Alessandra Reis
BACKGROUND: In this randomized study, split-mouth, triple-blind clinical trial, the authors evaluated the efficacy of a desensitizing gel that contained 5% potassium nitrate and 5% glutaraldehyde applied before in-office bleaching with 35% hydrogen peroxide (HP). METHODS: Treatment with the desensitizing or placebo control gels was randomly assigned to one-half of the maxillary teeth of 42 patients in a split-mouth design. The desensitizing gels were applied and maintained in contact with the tooth enamel for 10 minutes, followed by 2 HP bleaching sessions separated by 1 week...
February 10, 2018: Journal of the American Dental Association
https://www.readbyqxmd.com/read/29438186/peanut-allergy-reduction-in-high-risk-pediatric-patients
#13
Jaime Hopper, Courtney Hopp, Jessica Durbin
The prevalence of food allergies has doubled in the past 10 years. Peanut allergies are a significant public health issue and are the primary reason for food-related anaphylactic reactions that result in death. Evidence supports that early introduction of the peanut protein (or in combination with immunotherapy) to the highly allergic may safely desensitize patients, which could lead to less adverse allergic reactions and alter allergy management overall.
March 12, 2018: Nurse Practitioner
https://www.readbyqxmd.com/read/29437286/kidney-exchange-match-rates-in-a-large-multicenter-clearinghouse
#14
Courtenay M Holscher, Kyle Jackson, Eric Kh Chow, Alvin G Thomas, Christine E Haugen, Sandra R DiBrito, Carlin Purcell, Matthew Ronin, Amy D Waterman, Jacqueline Garonzik Wang, Allan B Massie, Sommer E Gentry, Dorry L Segev
Kidney paired donation (KPD) can facilitate living donor transplantation for candidates with an incompatible donor, but requires waiting for a match while suffering the morbidity of dialysis. The balance between waiting for KPD versus desensitization or deceased donor transplantation relies on the ability to estimate KPD wait times. We studied donor/candidate pairs in the National Kidney Registry (NKR), a large multi-center KPD clearinghouse, between 10/2011-9/2015 using a competing risk framework. Among 1894 candidates, 52% were male, median age was 50 years, 66% were white, 59% had blood type O, 42% had PRA>80, and 50% obtained KPD through NKR...
February 13, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29433764/cold-intolerance-after-nerve-injury
#15
Christine B Novak
Cold intolerance after nerve injury can be severe and has been associated with high levels of pain and disability. This article provides an overview of the assessment and nonoperative management of cold-induced symptoms after peripheral nerve injury. A comprehensive evaluation should include both objective measures such as skin temperatures and subjective tools to assess the patient's perspective and impact of the symptoms. Management of the patient with cold intolerance remains challenging and should include adaptive strategies, warming interventions, and desensitization conditioning programs to minimize cold-induced pain and hyperresponses...
February 9, 2018: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/29433504/successful-treatment-of-methotrexate-intolerance-in-juvenile-idiopathic-arthritis-using-eye-movement-desensitization-and-reprocessing-treatment-protocol-and-preliminary-results
#16
Lea Höfel, Bruno Eppler, Magdalena Storf, Elizabeth Schnöbel-Müller, Johannes-Peter Haas, Boris Hügle
BACKGROUND: Methotrexate (MTX), commonly used in juvenile idiopathic arthritis (JIA), frequently has to be discontinued due to intolerance with anticipatory and associative gastrointestinal adverse effects. Eye Movement Desensitization and Reprocessing (EMDR) is a psychological method where dysfunctional experiences and memories are reprocessed by recall combined with bilateral eye movements. The objective of this study was to assess efficacy of EMDR for treatment of MTX intolerance in JIA patients...
February 13, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29432966/rapid-oral-desensitization-protocol-to-abiraterone-acetate
#17
Miriam Verdu, Virginia Torres-Degayon, Mohamed Hassan-Bennis
No abstract text is available yet for this article.
February 9, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29428175/beyond-the-channel-metabotropic-signaling-by-nicotinic-receptors
#18
REVIEW
Nadine Kabbani, Robert A Nichols
The α7 nicotinic acetylcholine receptor (nAChR) is a ligand-gated ion channel (LGIC) that plays an important role in cellular calcium signaling and contributes to several neurological diseases. Agonist binding to the α7 nAChR induces fast channel activation followed by inactivation and prolonged desensitization while triggering long-lasting calcium signaling. These activities foster neurotransmitter release, synaptic plasticity, and somatodendritic regulation in the brain. We discuss here the ability of α7 nAChRs to operate in ionotropic (α7 i ) and metabotropic (α7 m ) modes, leading to calcium-induced calcium release (CICR) and G protein-associated inositol trisphosphate (IP 3 )-induced calcium release (IICR), respectively...
February 7, 2018: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/29427667/o-glcnacylation-modulates-pka-creb-signaling-in-a-manner-specific-to-pka-catalytic-subunit-isoforms
#19
Nana Jin, Denglei Ma, Jianlan Gu, Jianhua Shi, Xiaotao Xu, Khalid Iqbal, Cheng-Xin Gong, Fei Liu, Dandan Chu
O-GlcNAcylation is a post-translational modification of proteins. Protein kinase A (PKA)-cAMP response element binding protein (CREB) signaling plays critical roles in multiple biological processes. Isoforms α and β of PKA catalytic subunit (PKAc) and CREB are modified by O-GlcNAcylation. In the present study, we determined the role of O-GlcNAcylation in PKAc isoform-specific CREB signaling. We found that up-regulation of O-GlcNAcylation enhanced CREB phosphorylation, but suppressed CREB expression in exogenous PKAc isoform-unspecific manner...
February 7, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29427253/lack-of-connexin-40-decreases-the-calcium-sensitivity-of-renin-secreting-juxtaglomerular-cells
#20
Dominik Steppan, Lisa Geis, Lin Pan, Kenneth Gross, Charlotte Wagner, Armin Kurtz
The so-called calcium paradoxon of renin describes the phenomenon that exocytosis of renin from juxtaglomerular cells of the kidney is stimulated by lowering of the extracellular calcium concentration. The yet poorly understood effect of extracellular calcium on renin secretion appears to depend on the function of the gap junction protein connexin 40 (Cx40) in renin-producing cells. This study aimed to elucidate the role of Cx40 for the calcium dependency of renin secretion in more detail by investigating if Cx40 function is really essential for the influence of extracellular calcium on renin secretion, if and how Cx40 affects intracellular calcium dynamics in renin-secreting cells and if Cx40-mediated gap junctional coupling of renin-secreting cells with the mesangial cell area is relevant for the influence of extracellular calcium on renin secretion...
February 9, 2018: Pflügers Archiv: European Journal of Physiology
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