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https://www.readbyqxmd.com/read/28107097/comparison-of-systemic-and-topical-hypericum-perforatum-on-diabetic-surgical-wounds
#1
Mehmet Altıparmak, Teoman Eskitaşçıoğlu
BACKGROUND: Surgical wounds in diabetic patients still remain a problem till the present day. As a common plant found around the world, Hypericum perforatum L. (Hypericaceae) is traditionally prepared as an oily extract and used as a folk remedy for various diseases such as wounds, burns, cuts, etc. This study aims to evaluate the effect of St. John's wort (Hypericum perforatum) on problematic wounds while comparing oral and topical applications. METHODS: Incisional and excisional wound models were made on the dorsal regions of 54 diabetic Spraque-Dawley rats...
January 20, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28106169/inhibition-of-nucks-facilitates-corneal-recovery-following-alkali-burn
#2
Ming-Wai Poon, Dan Jiang, Peng Qin, Yuelin Zhang, Beiying Qiu, Sumit Chanda, Vinay Tergaonkar, Qing Li, Ian Y Wong, Zhendong Yu, Hung-Fat Tse, David S H Wong, Qizhou Lian
Corneal wound healing involves a complex cascade of cytokine-controlled cellular events, including inflammatory and angiogenesis responses that are regulated by transcriptional chromatin remodeling. Nuclear Ubiquitous Casein and cyclin-dependent Kinase Substrate (NUCKS) is a key chromatin modifier and transcriptional regulator of metabolic signaling. In this study, we investigated the role of NUCKS in corneal wound healing by comparing its effects on corneal alkali burn in NUCKS knockout (NKO) and NUCKS wild-type (NWT) mice...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28103988/-to-enhance-study-on-translation-and-application-of-mesenchymal-stem-cells-in-wound-repair
#3
D H Hu, W Zhang
Wound repair is a complicated process of interactions among numerous types of cells, involving the activation of multiple cells and various cytokines. The extensive burn and chronic wound are already big challenges for clinic due to the limitations of existing treatment means. Stem cell technology, as a new therapy, may be the optimum choice for wound repair. Mesenchymal stem cells are multipotent cells with self-renewal and differentiation capacity and have a broad tissue distribution, which are promising in treating wound, and it is worthy to discuss and analyze their role, clinical translation and application in wound repair, the facing problems at present and solving strategies as well...
January 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28103165/burn-wound-healing-present-concepts-treatment-strategies-and-future-directions
#4
A Oryan, E Alemzadeh, A Moshiri
Burns are the most extensive forms of soft tissue injuries occasionally resulting in extensive and deep wounds and death. Burns can lead to severe mental and emotional distress, because of excessive scarring and skin contractures. Treatment of burns has always been a difficult medical problem and many different methods have been used to treat such injuries, locally. Biofilms are a collection of microorganisms that delay wound healing. One of the new methods of prevention and treatment of burn wound infections is application of antimicrobials, which act on biofilms and prevent the wound infection...
January 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28099239/jewelry-ring-associated-electrothermal-burn-injuries-a-nine-patient-case-series
#5
Oren P Mushin, Jarrod T Bogue, Megan E Pencek, Derek E Bell
Ring-associated burns are infrequent, comprising only a small fraction of burn consults and admissions. However, because of the location of these burns and the propensity for circumferential wounds, small burn size may belie the severity of resultant injuries. Herein, the authors present their experience with this potentially severe type of burn. Records from a regional burn center were retrospectively analyzed during a 36-month period. All patients who sustained ring burns were included. Data points included demographics, burn location, need for surgical intervention, grafted area, hospital days (length of stay), percent graft take, complications, and time to re-epithelialization...
January 13, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28095550/the-diagnostic-role-of-optical-coherence-tomography-oct-in-measuring-the-depth-of-burn-and-traumatic-scars-for-more-accurate-laser-dosimetry-pilot-study
#6
Jill S Waibel, Ashley C Rudnick, Adam J Wulkan, Jon D Holmes
BACKGROUND: In recent decades, a number of optimal diagnostic technologies have emerged to assist in tissue visualization. Real-time monitoring of skin during laser therapies will help optimize laser parameters for more ef cient therapies. One of these technologies, optimal coherence tomography (OCT), may be used to help visualize burn and traumatic scars. When lasing severe scars, lasers have tunable pulse energies, which are made proportional to the scar thickness as estimated by palpation and the physician eye...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28092488/low-level-laser-therapy-in-enhancing-wound-healing-and-preserving-tissue-thickness-at-free-gingival-graft-donor-sites-a-randomized-controlled-clinical-study
#7
Gulbahar Ustaoglu, Esra Ercan, Mustafa Tunali
OBJECTIVE: The aim of this study was to determine the effects of low-level laser therapy (LLLT) on wound healing at free gingival graft (FGG) donor sites. MATERIALS AND METHODS: Forty patients requiring FGG were selected for this randomized, controlled, and double-blinded prospective clinical trial. The FGG donor sites were treated with LLLT and compared with an untreated control group. The Wound-Healing Index (WHI), tissue consistency, color match, and H2O2 bubbling test for the evaluation of complete wound epithelialization were recorded on the 3rd, 7th, 14th and 21st days...
January 12, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28091923/experimental-study-of-the-effects-of-nanodispersed-ceria-on-wound-repair
#8
O A Legon'kova, T A Ushakova, I P Savchenkova, N V Perova, M S Belova, A A Torkova, A E Baranchikov, O S Ivanova, A I Korotaeva, V K Ivanov
We studied the effects of nanodispersed ceria on wound healing in vitro and in vivo. It was found that cerium dioxide stimulated wound healing, which manifested in shrinkage of burn wound area (by 1.5 times) and intensification (by 2.4 times) marginal epithelialization.
January 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28089405/use-of-essential-oils-following-traumatic-burn-injury-a-case-study
#9
Kathleen Jopke, Heather Sanders, Rosemary White-Traut
Hospital admissions related to burn injury reach 40,000 annually. Patients who experience extensive burns require longer hospital stays and are at increased risk for infection and hospital acquired conditions. This comparative case study is a two patient matched case control design that follows the hospital course of two children who experienced burn injuries. For one of these patients, with the consent of the child's parents, the grandmother treated her granddaughter with essential oils. Essential oils have the potential to inhibit microbial growth, support treatment of wounds, and facilitate healing...
January 13, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28088439/antimicrobial-activity-of-photodynamic-therapy-in-combination-with-colistin-against-a-pan-drug-resistant-acinetobacter-baumannii-isolated-from-burn-patient
#10
Ebrahim Boluki, Hossein Kazemian, Hadi Peeridogaheh, Mohammad Yousef Alikhani, Sima Shahabi, Leili Beytollahi, Roghayeh Ghorbanzadeh
Nosocomially-acquired multi-, extensively-, and pandrug resistant (MDR, XDR, and PDR) strains of microorganisms such as Acinetobacter baumannii remain a serious cause of infection and septic mortality in burn patients. Treatment of patients with nosocomial burn wound infections is often complicated by drug-resistant strains of A. baumannii. Today, many researchers are focusing on the investigation of novel non-antibiotic strategies such as photodynamic therapy (PDT). We report a new PDT strategy that suppresses colistin resistance in PDR A...
January 11, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28079551/current-techniques-for-burn-reconstruction-using-dehydrated-human-amnion-chorion-membrane-allografts-as-an-adjunctive-treatment-along-the-reconstructive-ladder
#11
Paul M Glat, Thomas Davenport
The reconstructive ladder is a term coined by reconstructive plastic surgeons to describe levels of increasingly complex management of wounds. The first rungs of the ladder is allowing the wound to heal by secondary intention, advancing up the ladder to direct tissue closure, with skin grafting and tissue transfer (flaps) comprising the higher rungs. Skin grafting and tissue transfer (flaps) at the middle and higher rungs of the ladder are often necessary for the treatment of complex burn injuries. Our purpose is to describe how dehydrated human amnion/chorion membrane allografts may be used as an adjunctive treatment...
February 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28079550/the-use-of-dehydrated-human-amnion-chorion-membranes-in-the-treatment-of-burns-and-complex-wounds-current-and-future-applications
#12
Mayer Tenenhaus
Historically, biologic materials found in nature have been used for a wide variety of medicinal purposes, although their widespread use may be limited due to challenges in obtaining and properly preparing the material for safe clinical use. Amniotic membrane has long been recognized to possess unique properties favorable for healing. Dehydrated human amnion/chorion membrane allografts are commercially available for use in multiple sizes and configurations applicable for a variety of clinical settings and presentations...
February 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28079549/contemporary-methods-allowing-for-safe-and-convenient-use-of-amniotic-membrane-as-a-biologic-wound-dressing-for-burns
#13
David N Herndon, Ludwik K Branski
Partial-thickness burns involve damage to the upper layer of skin, which leaves nerve endings exposed, and therefore represent the most painful of several categories of thermal injuries. Historically, partial-thickness burns were treated conservatively by debriding the blisters, by daily tubbing and washing, and the application of new bandages with topical medications. Human amniotic membrane has been used for centuries as a biological wound dressing. In the past 20 years, there has been an increasing body of literature addressing the use of amniotic tissue in chronic wounds and burns...
February 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28079548/history-and-advancement-of-burn-treatments
#14
Hai-Fei Liu, Feng Zhang, William C Lineaweaver
Advances in burn care have accelerated within the last 50 years. The principal modalities of and approaches to burn treatment include dressings, antimicrobials, fluid resuscitation, burn wound excision, skin grafting, and use of skin substitutes. This review presents a historical outline of these approaches, their current status, and prospects for the future of burn care.
February 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28078188/new-innovations-for-deep-partial-thickness-burn-treatment-with-acell-matristem-matrix
#15
Justine S Kim, Alexander J Kaminsky, J Blair Summitt, Wesley P Thayer
Objective: Burn injuries remain a large financial burden on the healthcare system. According to CDC statistics (2010), nonfatal and hospitalized burns in the U.S. cost $1.8 billion for an annual incidence of ∼486,000 cases. To date, no technique proves to be the ideal therapy of deep partial-thickness burns. In this study, we review a trial usage of ACell (ACell, Inc.) wound matrix on deep partial-thickness burns. Approach: Burn patients were admitted through the Vanderbilt Emergency Department. Three were consented to receive ACell therapy...
December 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/28074719/-ten-tips-for-initial-assessment-and-treatment-of-minor-burns
#16
G L Vlaspolder, A F P M Vloemans, R S Breederveld
The initial care of a patient with burns is a challenge for every doctor. After cooling the burn appropriately, a careful history and a good initial assessment are of essential importance for treatment. The burn should be inspected regularly for early detection of any infection and to evaluate wound healing. If healing has not occurred in two weeks, hypertrophic scarring may develop and surgical treatment should be considered. It is always possible to contact the burns centres in Beverwijk, Rotterdam and Groningen to discuss treatment of the burn, any infection of a wound, consideration of surgical treatment, or transfer of a patient to a burn centre...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28069343/the-unusual-presentation-of-a-burn-from-methyl-bromide-exposure-a-case-report-and-review-of-the-literature
#17
Gloria R Sue, Yvonne L Karanas, Drew J Davis, Barry Press
Methyl bromide chemical burns are rare. Only two cases have been reported to date. The presentation of methyl bromide chemical burns is unusual. Patients with an acute exposure should be observed closely as the initial presentation can appear deceptively benign. The latency period lasts several hours prior to the development of chemical burn wounds. In this article, we review the literature on methyl bromide chemical burns and present our experience managing a patient with an extensive methyl bromide burn.
January 6, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28068397/burn-injury-leads-to-increased-long-term-susceptibility-to-respiratory-infection-in-both-mouse-models-and-population-studies
#18
Vanessa S Fear, James H Boyd, Suzanne Rea, Fiona M Wood, Janine M Duke, Mark W Fear
BACKGROUND: Burn injury initiates an acute inflammatory response that subsequently drives wound repair. However, acute disruption to the immune response is also common, leading to susceptibility to sepsis and increased morbidity and mortality. Despite increased understanding of the impact of burn injury on the immune system in the acute phase, little is known about long-term consequences of burn injury on immune function. This study was established to determine whether burn injury has long-term clinical impacts on patients' immune responses...
2017: PloS One
https://www.readbyqxmd.com/read/28067286/a-novel-chimeric-lysin-with-robust-antibacterial-activity-against-planktonic-and-biofilm-methicillin-resistant-staphylococcus-aureus
#19
Hang Yang, Huaidong Zhang, Jing Wang, Junping Yu, Hongping Wei
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most threatening pathogens due to its multi-drug resistance (MDR) and strong biofilm-forming capacity. Here, we described the screening of a novel chimeolysin (ClyF) that was active against planktonic and biofilm MRSA. Biochemical tests showed that ClyF was active against all S. aureus clinical isolates tested under planktonic and biofilm conditions. Structure analysis revealed that ClyF has an enhanced thermostability and pH tolerance than its parental lysin Pc by forming a hydrophobic cleft in the catalytic domain and an Ig-like structure in the cell-wall binding domain...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28065968/therapeutic-uses-of-pineapple-extracted-bromelain-in-surgical-care-a-review
#20
Zehra Abdul Muhammad, Tashfeen Ahmad
Bromelain is an extract obtained from the pineapple plant and is used as a traditional folk remedy for several ailments. In this review, a comprehensive electronic database search was carried out to compile available literature on therapeutic implications of bromelain. Pharmaceutical value of bromelain has been demonstrated in different surgical sub-specialties. Diverse biological processes like anti-inflammatory, anti-oedematous, analgesic, anti-thrombotic, exfoliation etc. are involved in bromelain's therapeutic actions, mediated through the kallikrein-kinin and arachidonic acid pathways as well as through effects on cell mediated immunity...
January 2017: JPMA. the Journal of the Pakistan Medical Association
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