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https://www.readbyqxmd.com/read/28437853/inhibition-of-tgf-%C3%AE-signaling-promotes-expansion-of-human-epidermal-keratinocytes-in-feeder-cell-co-culture
#1
Daisuke Suzuki, Filipa Pinto, Makoto Senoo
Cultured epidermal autografts have been used worldwide since 1981 for patients with extensive third-degree burn wounds and limited skin donor sites. Despite significant progress in techniques toward improving clinical outcome of skin grafts, the long in vitro preparation time of cultured autografts has remained a major factor limiting its widespread use. Here, we show that pharmacological inhibition of TGF-β signaling promotes the expansion of human epidermal keratinocytes (HEKs) with high proliferative potential in co-cultures with both murine 3T3-J2 cells and human feeder cells, including dermal fibroblasts and preadipocytes...
April 24, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28435821/utilization-of-pfge-as-a-powerful-discriminative-tool-for-the-investigation-of-genetic-diversity-among-mrsa-strains
#2
Solmaz Ohadian Moghadam, Mohammad Reza Pourmand, Masoumeh Douraghi, Samira Sabzi, Parisa Ghaffari
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is a significant challenge to the burn patient. The implementation of proper monitoring programs and prompt identification of epidemic MRSA strains are critical to consequently control and eradicate potential outbreaks. This study aimed to define the genetic relatedness of MRSA strains isolated from burn patients by analyzing the large fragments of DNA. METHODS: In this cross-sectional study, 126 pus/wound swabs from skin and soft tissue infections (SSTIs) were collected from inpatients of Shahid Motahari Burn Center (Tehran, Iran) in 2013...
March 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28435812/scientometrics-on-public-health-research-in-iran-increase-of-area-studies-despite-embargoes-a-review-article
#3
REVIEW
Brice Poreau
BACKGROUND: Due to embargoes and sanctions from 1979 until 2015, impact on scientific research in Iran may be critical. Public health is the main example of this burning point. In this paper, the aim was to map the scientific research in public health in Iran until 2014 with area studies as well as networks of countries involved. METHODS: We used bibliographic analyses using VOS viewer software for network analysis during the period 1975-2014. Two databases were used: Web of Science and PubMed...
March 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28428966/nutrition-and-metabolism-in-burn-patients
#4
REVIEW
Audra Clark, Jonathan Imran, Tarik Madni, Steven E Wolf
Severe burn causes significant metabolic derangements that make nutritional support uniquely important and challenging for burned patients. Burn injury causes a persistent and prolonged hypermetabolic state and increased catabolism that results in increased muscle wasting and cachexia. Metabolic rates of burn patients can surpass twice normal, and failure to fulfill these energy requirements causes impaired wound healing, organ dysfunction, and susceptibility to infection. Adequate assessment and provision of nutritional needs is imperative to care for these patients...
2017: Burns and trauma
https://www.readbyqxmd.com/read/28427139/-advances-in-the-research-of-mechanism-in-prevention-and-treatment-of-scar-with-botulinum-toxin-type-a-and-its-clinical-application
#5
Y H Li, J Q Liu, D Xiao, W Zhang, D H Hu
Scar is a common complication in wound healing process, and how to effectively prevent and treat it is a hot and difficult problem in burns and plastic surgery field. Botulinum toxin type A is a neurotoxin that has been widely and effectively used in the cosmetic surgery field such as anti-wrinkle and thin face. In recent years, botulinum toxin type A has been applied in prevention and treatment of scar, which causes a great concern. Nowadays, the relevant reports have gradually increased, and the mechanisms have been explored more deeply...
April 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28427138/-advances-in-the-research-of-treatment-of-burns-in-the-elderly
#6
Z Y Jiang, D H Min, G H Guo
With our country going into the aging society, burns in the elderly often occur. Studies have shown that the number of elderly burn patients has reached 13% to 20% of the total number of burn patients. As the sensory and cognitive functions are low, skin is thinning, the functions of heart, lung, and kidney are reduced, the immunity is impaired, and other physiological characteristics exist in the elderly, the wounds of elderly burn patients often heal slowly, and the mortality is high. At present, there is still a lack of enough attention to the elderly burn patients...
April 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28427132/-influences-of-abar-gene-on-biofilm-formation-of-acinetobacter-baumannii
#7
H N Guo, J Xiang
Objective: To detect drug-resistant phenotype and abaR gene of Acinetobacter baumannii (AB) and investigate influences of abaR gene on biofilm formation of AB. Methods: From February to July 2014, 159 strains AB were collected from Department of Clinical Microbiology of Ruijin Hospital of School of Medicine of Shanghai JiaoTong University and numbered starting from 1 according time when they were collected. (1) The above-mentioned 159 strains of AB were identified by detecting gene sequence of 16S ribosomal DNA...
April 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28426571/growth-differentiation-factor-5-accelerates-wound-closure-and-improves-skin-quality-during-repair-of-full-thickness-skin-defects
#8
Jennifer L Schiefer, Manuel Held, Paul C Fuchs, Erhan Demir, Frank Plöger, Hans-Eberhard Schaller, Afshin Rahmanian-Schwarz
BACKGROUND: A fast and stable wound closure is important, especially for extended and unstable wounds found after burn injuries. Growth can regulate a variety of cellular processes, including those involved in wound healing. Growth differentiation factor 5 (GDF-5) can accelerate fibroblast cell migration, cell proliferation, and collagen synthesis, which are essential for wound healing. Nevertheless, no standardized evaluation of the effect of GDF-5 on the healing of full-thickness wounds has been published to date...
May 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28426569/salve-and-burdock-a-safe-effective-amish-remedy-for-treatment-of-traumatic-wounds
#9
Mitchell D Flurry, Kelsie L Herring, Logan W Carr, Randy M Hauck, John D Potochny
BACKGROUND: Amish patients show a demonstrated preference for traditional, herbal remedies over modern medical interventions such as skin grafting. One such remedy is a mixture of Burn & Wound Ointment (B & W Ointment; Holistic Acres, LLC; Newcomerstown, Ohio) and steeped burdock leaves. Although both have demonstrated some antimicrobial and wound healing properties, burdock and/or the combination of B & W Ointment and burdock has never been studied to determine its purported ability to reduce pain, prevent infection, and accelerate wound healing...
May 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28420569/identification-of-factors-predicting-scar-outcome-after-burn-in-adults-a-prospective-case-control-study
#10
Hilary J Wallace, Mark W Fear, Margaret M Crowe, Lisa J Martin, Fiona M Wood
This study examined influences on scarring after burn in a prospective study using a defined outcome measure: scar height measured by a modified Vancouver Scar Scale (mVSS). A prospective case-control study was conducted among 616 adult subjects who sustained a burn in Western Australia. Patient factors influencing scar outcome including gender, Fitzpatrick skin type and selected co-morbidities were explored, as well as injury and clinical factors. A logistic regression model for raised scar after burn was developed which achieved an overall correct prediction rate of 81...
April 15, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28415935/naringenin-improves-the-healing-process-of-thermally-induced-skin-damage-in-rats
#11
Abdulaziz S Al-Roujayee
Objective To evaluate the effect of the phenolic compound naringenin on thermal burn-induced inflammatory responses and oxidative stress in rats. Methods First degree thermal burn injuries were induced in shaved rats by 10 s immersion of the back surface in water at 90℃. Naringenin treatment (25, 50 and 100 mg/kg/day) was initiated 24 h following burn injury, and continued for 7 days. On treatment day 7, serum tumour necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, nitric oxide (NO), prostaglandin (PG)E2, caspase-3, leukotriene (LT)-B4 and nuclear factor (NF)-κB levels were quantified...
April 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28414861/management-of-necrotising-fasciitis-secondary-to-abdominal-liposuction-using-a-combination-of-surgery-hyperbaric-oxygen-and-negative-pressure-wound-therapy-in-a-patient-with-burn-scars
#12
I-Han Chiang, Shun-Cheng Chang, Chih-Hsin Wang
Liposuction is the one of the most frequently performed cosmetic operations and usually has an easy recovery, with a reportedly low overall complication rate. Here, we report the case of a 60-year-old woman with type II diabetes mellitus and a previous burn injury of the abdomen who underwent abdominal liposuction and subsequently developed necrotising fasciitis. Following radical debridement, systemic antibiotic administration, negative pressure wound therapy and hyperbaric oxygen therapy, the wound healed completely...
April 17, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28413115/rate-of-contamination-of-hospital-privacy-curtains-on-a-burns-and-plastic-surgery-ward-a-cross-sectional-study
#13
K Shek, R Patidar, Z Kohja, S Liu, J P Gawaziuk, M Gawthrop, A Kumar, S Logsetty
BACKGROUND: Surfaces in the patient environment may play a role in microbial transmission if they become colonized by bacteria. Patient privacy curtains are one such surface that may pose a high risk for transmission because they are high-contact surfaces, are infrequently cleaned, and healthcare workers are less likely to wash their hands after contacting inanimate objects such as curtains. AIM: To determine the amount and type of bacterial colonization of patient privacy curtains at a regional burns/plastic surgery unit...
March 16, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28412341/chitosan-a-potential-biopolymer-for-wound-management
#14
REVIEW
Ijaz Bano, Muhammad Arshad, Tariq Yasin, Muhammad Afzal Ghauri, Muhammad Younus
It has been seen that slow healing and non-healing wounds conditions are treatable but still challenging to humans. Wound dressing usually seeks for biocompatible and biodegradable recipe. Natural polysaccharides like chitosan have been examined for its antimicrobial and healing properties on the basis of its variation in molecular weight and degree of deacetylation. Chitosan adopts some vital characteristics for treatment of various kinds of wounds which include its bonding nature, antifungal, bactericidal and permeability to oxygen...
April 13, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28412131/screening-nasal-swabs-for-methicillin-resistant-staphylococcus-aureus-a-regional-burn-center-s-experience
#15
Shawn Tejiram, Laura S Johnson, Mihriye Mete, Sameer Desale, Kimberly Johnson, Jenny Zhang, Lauren T Moffatt, Jeffrey W Shupp
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogen that can result in substantial morbidity and mortality. Early detection of MRSA colonization by screening nasal swabs may be important in the management of burn-injured patients. However, studies examining its use in this population are limited. The aim of this study was to study the utility of admission MRSA screening nasal swabs and determine if being positive for MRSA on admission impacted outcomes. MATERIALS AND METHODS: A retrospective review was conducted of burn patients who presented to a single regional burn center between June 2012 and December 2014...
April 12, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28410933/the-role-of-complement-in-the-acute-phase-response-after-burns
#16
REVIEW
H Ibrahim Korkmaz, Paul A J Krijnen, Magda M W Ulrich, E de Jong, Paul P M van Zuijlen, Hans W M Niessen
Severe burns induce a complex systemic inflammatory response characterized by a typical prolonged acute phase response (APR) that starts approximately 4-8h after-burn and persists for months up to a year after the initial burn trauma. During this APR, acute phase proteins (APPs), including C-reactive protein (CRP) and complement (e.g. C3, C4 and C5) are released in the blood, resulting amongst others, in the recruitment and migration of inflammatory cells. Although the APR is necessary for proper wound healing, a prolonged APR can induce local tissue damage, hamper the healing process and cause negative systemic effects in several organs, including the heart, lungs, kidney and the central nervous system...
April 11, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28410932/outcome-analysis-of-colistin-treated-burn-center-patients
#17
Rachel E Wilkinson, David M Hill, William L Hickerson
OBJECTIVES: Intravenous colistimethate sodium (CMS) use in burn center patients is increasing due to the emergence of multidrug-resistant gram-negative bacteria. However, optimal dosing strategies and factors that may contribute to treatment failure are limited. The purpose of this study was to determine factors that may contribute to treatment failure in colistin-treated burn center patients. METHODS: This retrospective, observational study included burn center patients that received ≥48h of intravenous CMS between June 1, 2009 and June 30, 2014...
April 11, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28408145/cost-effectiveness-of-silver-dressings-for-paediatric-partial-thickness-burns-an-economic-evaluation-from-a-randomized-controlled-trial
#18
E Gee Kee, K Stockton, R M Kimble, L Cuttle, S M McPhail
BACKGROUND: Partial thickness burns of up to 10% total body surface area (TBSA) in children are common injuries primarily treated in the outpatient setting using expensive silver-containing dressings. However, economic evaluations in the paediatric burns population are lacking to assist healthcare providers when choosing which dressing to use. The aim of this study was to conduct a cost-effectiveness analysis of three silver dressings for partial thickness burns ≤10% TBSA in children aged 0-15 years using days to full wound re-epithelialization as the health outcome...
April 10, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28403868/the-use-of-viscoelastic-haemostatic-assays-in-goal-directing-treatment-with-allogeneic-blood-products-a-systematic-review-and-meta-analysis
#19
REVIEW
Mathilde Fahrendorff, Roberto S Oliveri, Pär I Johansson
BACKGROUND: Management of the critically bleeding patient can be encountered in many medical and surgical settings. Common for these patients is a high risk of dying from exsanguination secondary to developing coagulopathy. The purpose of this meta-analysis was to systematically review and assess randomised controlled trials (RCTs) performed on patients in acute need for blood transfusions due to bleeding to evaluate the effect of viscoelastic haemostatic assay (VHA) guidance on bleeding, transfusion requirements and mortality...
April 13, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28403020/understanding-the-impact-of-preservation-methods-on-the-integrity-and-functionality-of-placental-allografts
#20
Amy Johnson, Alexandra Gyurdieva, Sandeep Dhall, Alla Danilkovitch, Yi Duan-Arnold
INTRODUCTION: Human placental membranes (hPMs) have a long history in treating burns and wounds. The composition of hPMs includes structural matrix, growth factors, and neonatal cells, all of which contribute to their regenerative potential. However, most hPM products are devitalized after dehydration and irradiation. We compared the functionality of single-layer viable cryopreserved human amniotic membrane (vCHAM) with multilayer devitalized dehydrated human amnion/chorion membrane (dHACM) in wound-relevant models to determine the effect of different processing methods on hPMs...
April 12, 2017: Annals of Plastic Surgery
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