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https://www.readbyqxmd.com/read/29049055/oxidized-regenerated-cellulose-collagen-dressings-review-of-evidence-and-recommendations
#1
Stephanie Wu, Andrew J Applewhite, Jeffrey Niezgoda, Robert Snyder, Jayesh Shah, Breda Cullen, Gregory Schultz, Janis Harrison, Rosemary Hill, Melania Howell, Marcus Speyrer, Howard Utra, Jean de Leon, Wayne Lee, Terry Treadwell
OBJECTIVE: Healthcare systems are being challenged to manage increasing numbers of nonhealing wounds. Wound dressings are one of the first lines of defense in wound management, and numerous options exist. The oxidized regenerated cellulose (ORC)/collagen dressing may offer healthcare providers a robust and cost-effective tool for use in a variety of wounds. DESIGN: A multidisciplinary panel meeting was convened to discuss the use of ORC/collagen dressings in wound care and provide practice recommendations...
November 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29037870/the-antibacterial-and-anti-inflammatory-investigation-of-lawsonia-inermis-gelatin-starch-nano-fibrous-dressing-in-burn-wound
#2
Zhina Hadisi, Jhamak Nourmohammadi, Seyed Mahdi Nassiri
The aim of this study was to develop a new bioactive gelatin-oxidized starch nanofibers containing Lawsonia Inermis (henna) for treating second-degree burn wounds. Continuous, smooth, and bead-free fibers were obtained when the gelatin-starch ratio was 70/30.
Additionally, the fiber dimeter was reduced with increasing henna content. The successful loading of henna in the gelatin-oxidized starch nanofibers was approved using Fourier transform infrared spectroscopy and Differential scanning calorimetry. Moreover, the addition of henna to the gelatin-oxidized starch nanomatrix enhanced fibroblasts attachment, proliferation, collagen secretion, and antibacterial activity...
October 13, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29034271/effect-of-propolis-extract-in-combination-with-eugenol-free-dressing-coe-paktm-on-pain-and-wound-healing-after-crown-lengthening-a-randomized-clinical-trial
#3
Mitra Askari, Anna Saffarpour, Jalal Purhashemi, Atena Beyki
STATEMENT OF THE PROBLEM: Researchers have long been in search of products to enhance healing and patient comfort postoperatively. PURPOSE: This study aimed to assess the efficacy of propolis extract in combination with Coe-Pak(TM) dressing for pain relief and wound healing after crown lengthening surgery. MATERIALS AND METHOD: This randomized clinical trial was performed on 36 patients who were randomly divided into two groups of Coe-Pak(TM) dressing with (trial group) and without (control group) propolis extract...
September 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29034128/antibiotic-sensitivity-pattern-of-klebsiella-species-in-burn-wounds-at-bai-jerbai-wadia-hospital-for-children-mumbai-india-a-21-year-study
#4
Shankar Srinivasan, Jovita Saldanha, Suhas Abhyankar, Nikunj Modi, Aakanksha Patil, Arvind M Vartak
In our study, we attempt to look at the sensitivity pattern of the most commonly found microorganism in the wound swab of pediatric burn patients at our hospital, 'Klebsiella', to a number of commonly used antibiotics and to determine whether there has been a change in the sensitivities in the 21 year period between 1994 to 2014. The sensitivity was tested in vitro and antibiotics were administered to patients based on laboratory findings. Klebsiella shows a significant change in sensitivity pattern over last 21 years...
2017: International Journal of Burns and Trauma
https://www.readbyqxmd.com/read/29034127/socio-demographic-factors-which-significantly-relate-to-the-prediction-of-burns-severity-in-children
#5
Khalid Alnababtah, Salim Khan
BACKGROUND: Burns are considered one of the biggest wounds and the most devastating injuries humans can receive as they have prolonged consequences which are not only physical, but psychological in addition to the cost of treatment. The aim of the study was to explore the relationships between socio-demographic factors (SDF) and the incidence and mechanisms of burn injuries in children. The objectives were to identify the multiple and various factors responsible for the occurrence of significant burns in children; to explore and investigate the relationship between these factors; to critically analyse SDF on the incidence and mechanisms of burns and to develop a contextual model with a view to informing future health care policy and health promotion programmes...
2017: International Journal of Burns and Trauma
https://www.readbyqxmd.com/read/29033110/investigating-of-four-main-carbapenem-resistance-mechanisms-in-high-level-carbapenem-resistant-pseudomonas-aeruginosa-isolated-from-burn-patients
#6
Soodabeh Rostami, Ahmad Farajzadeh Sheikh, Saeed Shoja, Abbas Farahani, Mohammad Amin Tabatabaiefar, Abbas Jolodar, Raheleh Sheikhi
BACKGROUND: Pseudomonas aeruginosa is an opportunistic pathogen involved in many infections. Carbapenem-resistant P.aeruginosa has emerged as an important cause of infection in different hospitals worldwide. We aimed to determine frequencies of the four main resistance mechanisms [metallo-beta lactamase (MBL) production (blaIMP, blaVIM, blaSPM and blaNDM), overproduction of the MexAB-OprM and MexXY efflux pumps, overproduction of chromosome-encoded AmpC β-lactamase, and reduced OprD expression] in high-level carbapenem-resistant P...
October 9, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29033046/eschar-removal-by-bromelain-based-enzymatic-debridement-nexobrid-%C3%A2-in-burns-an-european-consensus
#7
Christoph Hirche, Antonella Citterio, Henk Hoeksema, Ján Koller, Martina Lehner, José Ramón Martinez, Stan Monstrey, Alexandra Murray, Jan A Plock, Frank Sander, Alexandra Schulz, Benjamin Ziegler, Ulrich Kneser
Early debridement and/or eschar removal is regarded as a significant step in the treatment of deep partial and full thickness burns. It aims to control wound bioburden and allows early wound closure by conservative treatment or skin grafting. Preservation of viable dermis accompanied by early wound closure, is regarded as a necessary step to reduce scar related complication, e.g. functional limitations and/or unaesthetic scar formation. Aside from the classical techniques of surgical excision as tangential excision for eschar removal, hydro-surgery, maggot therapy, laser, enzymatic debridement have been described as additional techniques in the burn surgeon's armamentarium...
October 12, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29032980/management-of-finger-deep-burns-the-interest-of-local-flaps
#8
Franck Duteille, Audrey Leduc, Julien Verdier, Michael Atlan, Pierre Perrot
INTRODUCTION: The management of finger deep burns is still problematic for the surgeon. Due to the fineness and the thickness of the subcutaneous tissue, after excision there is an important risk of exposure of the underlying tissue like bone, nerve or tendons. Local flaps (random pattern flap and pedicle flap) allowed ensuring a good quality covering with a tissue with many advantages (good thickness, sensitivity). On the contrary of all other techniques, flaps can be used independently from the vascular quality of the wound bed...
October 9, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29032979/a-treatment-algorithm-for-the-management-of-intraoral-burns-a-narrative-review
#9
REVIEW
Steve Kang, Kenneth Kufta, Thomas P Sollecito, Neeraj Panchal
Oral mucosa follows a distinctly different trajectory of wound healing than skin. Although there are contemporary guidelines regarding treatment of burns to the skin, there is no standard of care specific to intraoral burns. This narrative review proposes an evidence-based treatment algorithm for the management of intraoral burns. Data was collated through a comprehensive review of the literature and only included studies that have reported particular success with favorable short- and long-term prognoses. In order to critically appraise the strength of the treatment recommendations, the GRADE criteria was applied to each arm of the algorithm...
October 9, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29032975/comparison-of-non-surgical-methods-for-the-treatment-of-deep-partial-thickness-skin-burns-of-the-hand
#10
Ernest Zacharevskij, Gytis Baranauskas, Karolis Varkalys, Rytis Rimdeika, Darius Kubilius
This paper describes a randomized, controlled, parallel-group, single-center clinical trial designed to compare non surgical treatment methods of deep partial thickness skin burns of the hand. All patients were scanned with the Laser Doppler Imaging device to determine the depth of the burn wound. Viable keratinocytes sites were determined according to the established Perfusion Units (PU) measurement system. The trial enrolled 87 patients with hand burn wounds in the section of 260-600PU. Hand burn patients were divided into the following four groups: treated with hydrocolloid dressings; treated with mechanical debridement of monofilament polyester fibers pad and then applying silver sulfadiazine; treated with gauze dressings containing enzymatic collagenase preparation...
October 9, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29032974/prospective-comparative-evaluation-study-of-laser-doppler-imaging-and-thermal-imaging-in-the-assessment-of-burn-depth
#11
Christopher Wearn, Kwang Chear Lee, Joseph Hardwicke, Ammar Allouni, Amy Bamford, Peter Nightingale, Naiem Moiemen
INTRODUCTION: The accurate assessment of burn depth is challenging but crucial for surgical excision and tissue preservation. Laser Doppler Imaging (LDI) has gained increasing acceptance as a tool to aid depth assessment but its adoption is hampered by high costs, long scan times and limited portability. Thermal imaging is touted as a suitable alternative however few comparison studies have been done. METHODS: Sixteen burn patients with 52 regions of interests were analysed...
October 9, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29032968/early-intervention-by-captopril-does-not-improve-wound-healing-of-partial-thickness-burn-wounds-in-a-rat-model
#12
Johanneke J J Akershoek, Katrien M Brouwer, Marcel Vlig, Bouke K H L Boekema, Rob H J Beelen, Esther Middelkoop, Magda M W Ulrich
The Renin Angiotensin System is involved in fibrotic pathologies in various organs such as heart, kidney and liver. Inhibition of this system by angiotensin converting enzyme antagonists, such as Captopril, has been shown beneficial effects on these pathologies. Captopril reduced the inflammatory reaction but also directly influenced the fibrotic process. Prolonged and excessive inflammatory response is a major cause of hypertrophic scar formation in burns. We therefore evaluated the effect of Captopril on the healing of partial thickness burn wounds in a rat model...
October 9, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29031640/the-application-of-mesenchymal-stem-cells-to-treat-thermal-and-radiation-burns
#13
Kathleen Rodgers, Sachin S Jadhav
Mesenchymal stem cells (MSCs) have been developed for a number of indications due to their regenerative and anti-inflammatory phenotypes and their utility is enhanced by the fact that allogeneic transplant is feasible with this cell type. Animal studies and early human cases indicate this has the potential to be an exciting new therapy for treating chronic non-healing wounds such as diabetic ulcers, burns and cutaneous radiation burns. This review will focus on the use of MSCs to treat thermal and radiation burns...
October 11, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29029855/improving-mortality-outcomes-of-stevens-johnson-syndrome-toxic-epidermal-necrolysis-a-regional-burns-centre-experience
#14
M Nizamoglu, J A Ward, Q Frew, H Gerrish, N Martin, A Shaw, D Barnes, O Shelly, B Philp, N El-Muttardi, P Dziewulski
INTRODUCTION: Stevens Johnson Syndrome/toxic epidermal necrolysis (SJS/TEN) are rare, potentially fatal desquamative disorders characterised by large areas of partial thickness skin and mucosal loss. The degree of epidermal detachment that occurs has led to SJS/TEN being described as a burn-like condition. These patients benefit from judicious critical care, early debridement and meticulous wound care. This is best undertaken within a multidisciplinary setting led by clinicians experienced in the management of massive skin loss and its sequelae...
October 10, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29028413/initial-assessment-treatment-and-follow-up-of-minor-pediatric-burn-wounds-in-four-patients-remotely-a-preliminary-communication
#15
Marek A Paul, Parisa Kamali, Ahmed M S Ibrahim, Caroline Medin, Bernard T Lee, Samuel J Lin
BACKGROUND: Close, multidisciplinary collaboration with burn experts is the essential strategy to achieve the best functional and esthetic outcomes in burn wound treatment. Management of minor burn injuries, where no specialized care is available, might be challenging. One concept to achieve a fast and timely result is the application of telemedicine. The objective of this study was to assess and develop a simple telemedicine protocol, which can be applied globally. MATERIAL AND METHODS: We present a pilot study based on a pediatric population of four patients with minor burns...
October 13, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/29025669/preparation-and-evaluation-of-squid-ink-polysaccharide-chitosan-as-a-wound-healing-sponge
#16
Na Huang, Jiali Lin, Sidong Li, Yifeng Deng, Songzhi Kong, Pengzhi Hong, Ping Yang, Mingneng Liao, Zhang Hu
A new type of wound healing agent was developed using two marine biomaterials (squid ink polysaccharide and chitosan) as carriers and calcium chloride as an initiator for coagulation. Based on central composite design-response surface methodology, comprehensive evaluation of appearance quality for composite sponges and water absorbency were used as evaluation indices to identify the optimized preparation conditions and further evaluate the performance of the squid ink polysaccharide-chitosan sponge (SIP-CS)...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29023944/reconsidering-the-h-e-stain-as-the-gold-standard-in-assessing-the-depth-of-burn-wounds
#17
Arlene S Rosenberg
While histological examination is considered by most as the gold standard for burn depth assessment, it has no practical use in the clinical setting. It has, however, been used in the research setting, as a mean for evaluating emerging techniques of depth measurement. Due to the limitations of the H&E stain, other stains have also been explored, such as lactate dehydrogenase (LDH), as presented in this issue, in "Improving the Histologic Characterization of Burn Depth." As the determination of burn depth is not a typical subject in dermatopathology, a summary of selected techniques and the possible role for the LDH stain in future research, is described herein...
October 11, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29021723/bacterial-infections-in-burn-wound-patients-at-a-tertiary-teaching-hospital-in-accra-ghana
#18
O A Forson, E Ayanka, M Olu-Taiwo, P J Pappoe-Ashong, P J Ayeh-Kumi
Intact human skin surface is essential for protection against infection, preservation of body fluid homeostasis and thermoregulation. Burn injury compromises the skin barrier and enables bacterial infection, hence delaying burn wound healing. This study aimed to determine the microbial profile of burn wounds, and resistance patterns of microbes with respect to the source of the injured patient's wound. Fifty wound swab samples were collected from fifty burn patients at the Korle-Bu Teaching Hospital, Accra (KBTH)...
June 30, 2017: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/29020479/silicone-gel-enhances-the-efficacy-of-er-yag-laser-treatment-for-atrophic-acne-scars-a-randomized-split-face-evaluator-blinded-placebo-controlled-comparative-trial
#19
Jenvajee Khamthara, Chanat Kumtornrut, Korbkarn Pongpairoj, Pravit Asawanonda
BACKGROUND: The effect of topical silicone gel has been studied to prevent scars from burn, post operative wound and to treat hypertrophic scars. No previous studies have been done to evaluate the efficacy of topical silicone gel on atrophic acne scars. MATERIAL AND METHODS: Nineteen patients were treated with 3 sessions of ablative Er:YAG laser with 1-month intervals. Following each laser treatment, the randomly-assigned silicone gel or placebo were applied in split-face manner...
October 11, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29018761/using-stem-cell-biology-to-study-and-treat-ophthalmologic-and-oculoplastic-diseases
#20
REVIEW
Albert Y Wu, Michael G Daniel
With the rapid growth of the stem cell biology field, the prospect of regenerative medicine across multiple tissue types comes closer to reality. Several groundbreaking steps paved the way for applying stem cell biology to the several subfields within ophthalmology and oculoplastic surgery. These steps include the use of stem cell transplants as well as studies of various ophthalmologic pathologies at the molecular level. The necessity of stem cell transplant is readily apparent, having already been used for several studies such as artificial lacrimal gland design and eyelid reconstruction...
April 2017: Taiwan Journal of Ophthalmology
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