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https://www.readbyqxmd.com/read/29457376/delivery-of-allogeneic-adipose-stem-cells-in-polyethylene-glycol-fibrin-hydrogels-as-an-adjunct-to-meshed-autografts-after-sharp-debridement-of-deep-partial-thickness-burns
#1
David M Burmeister, Randolph Stone, Nicole Wrice, Alfred Laborde, Sandra C Becerra, Shanmugasundaram Natesan, Robert J Christy
Harvesting of autografts results in donor site morbidities and is limited in scenarios such as large total body surface area burns. In these instances, coverage is increased by meshing grafts at the expense of delayed biologic closure. Moreover, graft meshing increases the likelihood of contraction and hypertrophic scarring, limits range of motion, and worsens cosmesis. Many tissue engineering technologies have touted the promise of adipose-derived stem cells (ASCs) for burn wounds. The primary objective of the current study was to determine feasibility and efficacy of in situ ASC delivery via PEGylated fibrin (FPEG) hydrogels as adjuncts to meshed split thickness skin grafts in a porcine model...
February 18, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29453974/genetically-modified-bone-mesenchymal-stem-cells-with-tgf-%C3%AE-3-improve-wound-healing-and-reduce-scar-tissue-formation-in-a-rabbit-model
#2
Mingyong Li, Lin Qiu, Wei Hu, Xiang Deng, Hanfeng Xu, Youhan Cao, Zijian Xiao, Liangyu Peng, Shawn Johnson, Lyundup Alexey, Paul A Kingston, Qing Li, Yuanyuan Zhang
Extensive scar tissue formation often occurs after severe burn injury, trauma, or as one of complications after surgical intervention. Despite significant therapeutic advances, it is still a significant challenge to manage massive scar tissue formation while also promoting normal wound healing. The goal of this study was to investigate the therapeutic effect of bone mesenchymal stem cells (BMSCs) that were genetically modified to overexpress transforming growth factor-beta 3 (TGF-β 3 ), an inhibitor of myofibroblast proliferation and collagen type I deposition, on full-thickness cutaneous wound healing in a rabbit model...
February 14, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29453855/nerve-reinnervation-and-itch-behaviour-in-a-rat-burn-wound-model
#3
Tiam M Saffari, Barthold N Schüttenhelm, Johan W van Neck, Jan C Holstege
In this study, we investigated whether post-burn itch in rats, after a full thickness burn, is correlated to the nervous reinnervation of the burn wound area. For this purpose, we determined scratching duration (expressed as sec/hr) at 24 hours, 2, 4, 8 and 12 weeks post-burn and combined this with immunohistochemistry for protein gene product 9.5 (PGP9.5) to identify all nerve fibers, calcitonin gene related peptide (CGRP) to identify peptidergic fibers, tyrosine hydroxylase (TH) for sympathetic fibers and growth-associated protein 43 (GAP-43) for regrowing fibers...
February 17, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29452323/burr-hole-surgery-for-chronic-subdural-hematoma-with-extensive-scalp-burn-a-case-report
#4
Eijiro Echizen, Kei Miyata, Ken Yamashita, Takeshi Mikami, Eichi Narimatsu, Nobuhiro Mikuni
BACKGROUND: Neurosurgical intervention for a patient with an extensive scalp burn is rare, but it might be associated with the high risk of surgical site infection. CASE DESCRIPTION: An 80-year-old man had a severe and extensive scalp burn. A chronic subdural hematoma (CSDH) was observed on a head CT for the assessment of bacteremia during treatment in the intensive care unit. To evaluate whether the CSDH might underlie his prolonged fever and sepsis pathology, we urgently evacuated the hematoma using one burr hole...
February 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29448962/non-viral-gene-delivery-systems-for-tissue-repair-and-regeneration
#5
REVIEW
Pan Wu, Haojiao Chen, Ronghua Jin, Tingting Weng, Jon Kee Ho, Chuangang You, Liping Zhang, Xingang Wang, Chunmao Han
Critical tissue defects frequently result from trauma, burns, chronic wounds and/or surgery. The ideal treatment for such tissue loss is autografting, but donor sites are often limited. Tissue engineering (TE) is an inspiring alternative for tissue repair and regeneration (TRR). One of the current state-of-the-art methods for TRR is gene therapy. Non-viral gene delivery systems (nVGDS) have great potential for TE and have several advantages over viral delivery including lower immunogenicity and toxicity, better cell specificity, better modifiability, and higher productivity...
February 15, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29445581/eruptive-nevi-after-burn-injury
#6
Ali Tareen, Kristine Pallesen, Tine Vestergaard
Eruptive melanocytic nevi (EMN) is an unusual phenomenon characterized by the abrupt development of multiple melanocytic nevi over weeks to months in association with an underlying trigger. The underlying mechanisms are not fully understood, however, they have been associated with a variety of conditions. EMN is relatively uncommon and might be underreported due to the absence of close monitoring, insufficient recognition, and the presumed benign course of the condition. We describe the first case report of acral EMN associated with a burn wound on a 2-year-old child...
January 2018: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29443757/various-surgical-techniques-to-create-an-aesthetic-appearance-at-the-donor-site-of-anterolateral-thigh-free-flaps-based-on-the-oblique-branch-twenty-one-clinical-case-reports
#7
Chengliang Deng, Hai Li, Zairong Wei, Wenhu Jin, Kaiyu Nie, Shujun Li, Bihua Wu, Dali Wang
RATIONALE: Reducing the morbidity associated with anterolateral thigh (ALT) donor sites by performing aesthetic restoration has become a popular research topic. Various surgical techniques have been developed allowing for direct closure of the donor site. However, closure techniques for ALT donor sites based on the oblique branch have not been systematically reported. PATIENT CONCERNS: Data from 21 patients (18 males, 3 females) undergoing operative reconstruction with an ALT free flap between January 2016 and December 2016...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29442539/platelets-in-wound-healing-and-regenerative-medicine
#8
Julia Etulain
Although platelets are widely recognized as having a critical role in primary hemostasis and thrombosis, increasing experimental and clinical evidence identifies these enucleated cells as relevant modulators of other physiopathological processes including inflammation and tissue regeneration. These phenomena are mediated through the release of growth factors, cytokines, and extracellular matrix modulators that sequentially promote (i) revascularization of damaged tissue through the induction of migration, proliferation, differentiation, and stabilization of endothelial cells in new blood vessels; (ii) restoration of damaged connective tissue through migration, proliferation, and activation of fibroblasts; and (iii) proliferation and differentiation of mesenchymal stem cells into tissue-specific cell types...
February 14, 2018: Platelets
https://www.readbyqxmd.com/read/29442525/comparative-analysis-of-mesenchymal-stem-cells-from-bone-marrow-adipose-tissue-and-dental-pulp-as-sources-of-cell-therapy-for-zone-of-stasis-burns
#9
Ozan Luay Abbas, Orhan Özatik, Zeynep Burçin Gönen, Serdal Öğüt, Fikriye Yasemin Özatik, Hasan Salkın, Ahmet Musmul
INTRODUCTION: The implantation of mesenchymal stem cells (MSCs) has been shown to exert benefits for the survival of the zone-of-stasis. However, the clinical experience indicates the importance of selecting the right source and type of stem cells. Therefore, we planned the current study to perform a quantitative comparison of MSCs isolated from three different sources to provide information useful in selection of the optimal source and to see whether critical mechanisms are conserved between different populations...
February 14, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29440678/development-of-a-bacterial-cellulose-based-hydrogel-cell-carrier-containing-keratinocytes-and-fibroblasts-for-full-thickness-wound-healing
#10
Evelyn Yun Xi Loh, Najwa Mohamad, Mh Busra Fauzi, Min Hwei Ng, Shiow Fern Ng, Mohd Cairul Iqbal Mohd Amin
Bacterial cellulose (BC)/acrylic acid (AA) hydrogel has successfully been investigated as a wound dressing for partial-thickness burn wound. It is also a promising biomaterial cell carrier because it bears some resemblance to the natural soft tissue. This study assessed its ability to deliver human epidermal keratinocytes (EK) and dermal fibroblasts (DF) for the treatment of full-thickness skin lesions. In vitro studies demonstrated that BC/AA hydrogel had excellent cell attachment, maintained cell viability with limited migration, and allowed cell transfer...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29439974/efficacy-of-systemically-administered-polymyxins-in-mouse-burn-wound-infection-caused-by-multidrug-resistant-gram-negative-pathogens-a-proof-of-concept-study
#11
Yu-Wei Lin, Ke Chen, Jiping Wang, Tony Velkov, Qi Zhou, Jian Li
The efficacy of subcutaneously administered polymyxins against burn wound infections caused by Pseudomonas aeruginosa , Acinetobacter baumannii , and Klebsiella pneumoniae was examined in a murine infection model. Subcutaneously administered colistin and polymyxin B achieved a >2-log 10 reduction in the bacterial load for P. aeruginosa and A. baumannii infections, while wound infections by K. pneumoniae were less responsive (<1-log 10 reduction). This study highlights the potential therapeutic benefits of parenteral polymyxins for treating burn wound infections...
February 12, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29438144/long-term-scar-quality-after-treatment-of-standardized-partial-thickness-skin-graft-donor-sites
#12
Alexandra Schulz, Irene Rothermund, Rolf Lefering, Paul Christian Fuchs, Jennifer Schiefer
BACKGROUND: The long-term aesthetic appearance of scars is of great importance to patients. Biobrane (Smith and Nephew, Fort Worth, Texas), a biosynthetic skin dressing, is a successfully established dressing for the treatment of superficial wounds. A new silk barrier dressing (Dressilk; Prevor, Moulin de Verville, France) has also shown good results in wound healing. This study evaluated the long-term scar quality of superficial wounds treated with these dressings. METHODS: From February 2012 to May 2013, 11 patients with burns in need of skin grafting received donor site treatment...
March 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29432820/qpcr-detection-of-lichtheimia-species-in-bandages-associated-with-cutaneous-mucormycosis-in-burn-patients
#13
E Fréalle, S Rocchi, M Bacus, H Bachelet, L Pasquesoone, B Tavernier, D Mathieu, L Millon, M Jeanne
BACKGROUND: Cutaneous mucormycoses, mainly due to Lichtheimia (Absidia), have occurred on several occasions in the Burn Unit of the University Hospital of Lille, France. AIM: To investigate the potential vector role of non-sterile bandages used to hold in place sterile gauze used for wound dressing. METHODS: Mycological analysis by conventional culture, Mucorales qPCR, and Lichtheimia species-specific qPCR were performed on 8 crepe and 6 elasticized bandages that were sampled on two independent soccasions in March 2014 and July 2016...
February 9, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29430689/dystrophic-calcinosis-cutis-within-burns-successfully-treated-with-excision-and-secondary-intention-wound-healing
#14
K A Lockwood, T Oliphant
No abstract text is available yet for this article.
February 12, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29429747/treatment-of-corneal-chemical-alkali-burns-with-a-crosslinked-thiolated-hyaluronic-acid-film
#15
Gina L Griffith, Barbara Wirostko, Hee-Kyoung Lee, Lauren E Cornell, Jennifer S McDaniel, David O Zamora, Anthony J Johnson
PURPOSE: The study objective was to test the utilization of a crosslinked, thiolated hyaluronic acid (CMHA-S) film for treating corneal chemical burns. METHODS: Burns 5.5mm in diameter were created on 10 anesthetized, male New Zealand white rabbits by placing a 1N NaOH soaked circular filter paper onto the cornea for 30s. Wounds were immediately rinsed with balanced salt solution (BSS). CMHA-S films were placed in the left inferior fornix of five injured and five uninjured animals...
February 8, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29425875/burn-wound-healing-potential-of-a-polysaccharide-from-sanguisorba-officinalis-l-in-mice
#16
Hongfang Zhang, Junjie Chen, Ying Cen
Sanguisorba officinalis L. is widely used in China to treat various wounds, particularly burns. The present study was carried to evaluate the healing efficacy of a purified polysaccharide (SOP) from the roots of S. officinalis L. on burn wound models in mice. The results indicated that oral administration of SOP (50 and 200 mg/kg) significantly stimulated wound contraction and reduced epithelialization time as compared to control group, which might be mediated by promoting collagen synthesis as evidenced by an increase of hydroxyproline content...
February 6, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29424945/in-vitro-and-in-vivo-investigation-of-a-novel-amniotic-based-chitosan-dressing-for-wound-healing
#17
Maryam Momeni, Mohammad Zarehaghighi, Mirhamed Hajimiri, Ghasemali Khorasani, Rassoul Dinarvand, Abdolhossein Nekookar, Niloofar Sodeifi, Pardis Khosravani, Niloofar Shayanasl, Marzieh Ebrahimi
It is more than a decade that amniotic membrane has been used as a wound dressing because of its anti-inflammatory, anti-microbial, anti-fibrotic, anti-scaring properties, as well as its pain relieving and epithelialization promoting features. However, amniotic membrane had limited applications because it needs to suture in surgery, is highly fragile, firmly adhere to the wound and may cause bleeding and pain when changing the bandage. This study investigated the possibility of development of a novel amniotic-based chitosan gel dressing as a potential wound repair substrate with marked efficacy...
February 9, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29423009/negatively-charged-aerosol-improves-burn-wound-healing-by-promoting-enos-dependent-angiogenesis
#18
Jingling Zhao, Fei Zhou, Lei Chen, Bin Shu, Qiyi Zhai, Jun Wu, Xusheng Liu, Shaohai Qi, Yingbin Xu
Aerosols exist in the form of liquid or solid particles that stably suspending in air. Our previous studies have found that aerosol can accelerate chronic wound healing. However, the biological effects of aerosol in burn wound healing and the underlying molecular mechanism remain unclear. This study aimed to investigate the effects of aerosol on the healing of deep partial-thickness burn wounds and its regulatory mechanisms. By employing a self-controlled model of rats, we demonstrated that aerosol treatment not only increased the healing rate, but also improved the healing quality of deep partial-thickness burn wounds...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29421548/bacteria-responsive-intelligent-wound-dressing-simultaneous-in-situ-detection-and-inhibition-of-bacterial-infection-for-accelerated-wound-healing
#19
Jin Zhou, Danyu Yao, Zhiyong Qian, Sen Hou, Linhao Li, A Tobias A Jenkins, Yubo Fan
The evolved resistance of antibiotics exhibited by some dreaded clinical pathogens and formation of biofilms has caused life-threatening problems for patients with burns and other wounds. Here, in order to avoid antibiotic overuse, and thus decreasing the occurrence of antimicrobial-resistant bacteria, a theranostic wound dressing, composed of biocompatible UV-photocrosslinkable methacrylated gelatin (GelMA) encapsulating both antimicrobial and fluorescent vesicles, has been developed. The system can respond to the microbiological environment of the wound via a simple color change and antimicrobials release only when require and this is in essence passive as they do not respond to their local environments and benign bacteria, and only operates when pathogenic bacteria exist...
January 18, 2018: Biomaterials
https://www.readbyqxmd.com/read/29421318/antibacterial-resistance-biofilm-forming-ability-and-virulence-potential-of-pseudomonas-aeruginosa-isolated-from-burn-patients-in-northern-of-iran
#20
Leila Asadpour
OBJECTIVES: Pseudomonas aeruginosa is frequent in infectious diseases, such as burn and wound infections, making it one of the most promising opportunistic pathogens. The aim of this study was to investigate the antibiotic resistance, biofilm production capacity, and the frequency of genes, which are effective in the biofilm formation and virulence of Pseudomonas aeruginosa, from burn infections. METHODS: In this study, resistance of 90 P. aeruginosa strains to twelve antibacterial agents and extended-spectrum beta-lactamases (ESBLs) and Metallo-β-lactamases(MBL) enzymes production were phenotypically assessed according to Clinical & Laboratory Standards Institute guidelines...
February 5, 2018: Journal of Global Antimicrobial Resistance
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