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https://www.readbyqxmd.com/read/29165364/the-rosiglitazone-like-effects-of-vitexilactone-a-constituent-from-vitex-trifolia-l-in-3t3-l1-preadipocytes
#1
Atsuyoshi Nishina, Masaya Itagaki, Daisuke Sato, Hirokazu Kimura, Yasuaki Hirai, Nyunt Phay, Makoto Makishima
The increased number of patients with type 2 diabetes (T2D) has become a worldwide problem, and insulin sensitizers such as thiazolidinediones (TZDs) are used as therapeutic agents. We found that extracts of Vitex trifolia L. (V. trifolia), a medicinal plant from Myanmar, induced adipogenesis similar to rosiglitazone (ROS), which is a TZD, in 3T3-L1 preadipocytes. In the present study, we attempted to isolate from V. trifolia those compounds that showed ROS-like effects. Among the extracts of hexane, ethyl acetate, and methanol obtained from V...
November 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29165090/inhibition-of-adipogenesis-by-thiourea-derivatives
#2
Hina Siddiqui, Sarah Shafi, Farah Mukhtar, Asma Ejaz, Atta-Ur-Rahman, M Iqbal Choudhary
BACKGROUND: Obesity is one of the major health problem with inherent risk of type 2 diabetes, hypertension, CVDs etc. Adipogenesis is a major contributor in the process of obesity. Inhibition of adipocytes is one of the key approach to treat obesity. OBJECTIVE: To discover the new inhibitors of adipogenesis as the treatment for the obesity. METHOD: We describe here the synthesis and anti-adipogenic activity of thiourea derivatives 1-14. These derivatives were synthesized by the reactions of phenyl and pentafluorophenyl isothiocyanate with different aromatic amines...
November 20, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/29164883/raspberry-ketone-reduced-lipid-accumulation-in-3t3-l1-cells-and-ovariectomy-induced-obesity-in-wistar-rats-by-regulating-autophagy-mechanisms
#3
Sy-Ying Leu, Yi-Chen Chen, Yung-Chieh Tsai, Yao-Wen Hung, Chih-Hsiung Hsu, Yen-Mei Lee, Pao-Yun Cheng
This study aimed to determine the anti-obesity effects of raspberry ketone (RK), one of the major aromatic compounds contained in raspberry, and its underlying mechanisms. During adipogenesis of 3T3-L1 cells, RK (300 μM) significantly reduced lipid accumulation and downregulated the expression of CCAAT/enhancer-binding protein α (C/EBPα), peroxisome proliferation-activated receptor γ (PPARγ), fatty acid-binding protein 4 (FABP4), and fatty acid synthase (FAS). RK also reduced the expression of light chain 3B (LC3B), autophagy-related protein 12 (Atg12), sirtuin 1 (SIRT1), and phosphorylated-tuberous sclerosis complex 2 (TSC2), whereas it increased the level of p62 and phosphorylated-mammalian target of rapamycin (mTOR)...
November 22, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29162103/phenolic-compounds-apigenin-hesperidin-and-kaempferol-reduce-in-vitro-lipid-accumulation-in-human-adipocytes
#4
Saioa Gómez-Zorita, Arrate Lasa, Naiara Abendaño, Alfredo Fernández-Quintela, Andrea Mosqueda-Solís, Maria Pilar Garcia-Sobreviela, Jose M Arbonés-Mainar, Maria P Portillo
BACKGROUND: Adipocytes derived from human mesenchymal stem cells (MSCs) are widely used to investigate adipogenesis. Taking into account both the novelty of these MSCs and the scarcity of studies focused on the effects of phenolic compounds, the aim of the present study was to analyze the effect of apigenin, hesperidin and kaempferol on pre-adipocyte and mature adipocytes derived from this type of cells. In addition, the expression of genes involved in TG accumulation was also measured...
November 21, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29160030/dihydromyricetin-enhances-glucose-uptake-by-inhibition-of-mek-erk-pathway-and-consequent-down-regulation-of-phosphorylation-of-ppar%C3%AE-in-3t3-l1-cells
#5
Lei Liu, Min Zhou, Hedong Lang, Yong Zhou, Mantian Mi
Accumulating evidence suggests that inhibition of mitogen-activated protein kinase signalling can reduce phosphorylation of peroxisome proliferator-activated receptor γ (PPARγ) at serine 273, which mitigates obesity-associated insulin resistance and might be a promising treatment for type 2 diabetes. Dihydromyricetin (DHM) is a flavonoid that has many beneficial pharmacological properties. In this study, mouse fibroblast 3T3-L1 cells were used to investigate whether DHM alleviates insulin resistance by inhibiting PPARγ phosphorylation at serine 273 via the MEK/ERK pathway...
November 21, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29158445/pdgfr%C3%AE-pdgfr%C3%AE-signaling-balance-modulates-progenitor-cell-differentiation-into-white-and-beige-adipocytes
#6
Zhanguo Gao, Alexes C Daquinag, Fei Su, Brad Snyder, Mikhail G Kolonin
Relative abundance of thermogenic beige adipocytes and lipid-storing white adipocytes in adipose tissue underlie its metabolic activity. The roles of adipocyte progenitor cells, which express PDGFRα or PDGFRβ, in adipose tissue function have remained unclear. Here, by defining the developmental timing of PDGFRα and PDGFRβ expression in mouse subcutaneous and visceral adipose depots, we uncover depot-specificity of preadipocyte delineation. We demonstrate that PDGFRα expression precedes PDGFRβ expression in all subcutaneous but only in a fraction of visceral adipose stromal cells...
November 20, 2017: Development
https://www.readbyqxmd.com/read/29158057/the-wnt-%C3%AE-catenin-pathway-contributes-to-the-regulation-of-adipocyte-development-induced-by-docosahexaenoic-acid-in-grass-carp-ctenopharyngodon-idellus
#7
Pin Liu, Jing-Jing Tian, Hong Ji, Jian Sun, Chao Li, Ji-Qin Huang, Yang Li, Hai-Bo Yu, Er-Meng Yu, Jun Xie
Docosahexaenoic acid (DHA) has been suggested to inhibit adipogenesis in fish; the mechanism behind this observation remains largely unknown. The present study was to investigate the effects of DHA on the adipocyte differentiation of grass carp by using transcriptomic technology. Confluent primary cultured differentiating adipocytes were co-incubated with either 0μM or 100μM DHA for 2days (early phase of differentiation) and 7days (late phase). The results showed that 100μM DHA promoted adipogenesis at 2days but decreased lipid accumulation at 7days of treatment compared to that of the control...
November 17, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29156375/downregulation-of-the-protein-synthesis-machinery-is-a-major-regulatory-event-during-early-adipogenic-differentiation-of-human-adipose-derived-stromal-cells
#8
Bruna H Marcon, Fabíola B Holetz, Guillermo Eastman, Ana Carolina Origa-Alves, Mariana Andrea Amorós, Alessandra Melo de Aguiar, Carmen K Rebelatto, Paulo R S Brofman, Jose Sotelo-Silveira, Bruno Dallagiovanna
Commitment of adult stem cells involves the activation of specific gene networks regulated from transcription to protein synthesis. Here, we used ribosome profiling to identify mRNAs regulated at the translational level, through both differential association to polysomes and modulation of their translational rates. We observed that translational regulation during the differentiation of human adipose-derived stromal cells (hASCs, also known as adipose-derived mesenchymal stem cells), a subset of which are stem cells, to adipocytes was a major regulatory event...
November 1, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/29155314/mesenchymal-stromal-cell-irradiation-interferes-with-the-adipogenic-osteogenic-differentiation-balance-improving-their-hematopoietic-supporting-ability
#9
Silvia Preciado, Sandra Muntión, Ana Rico, Luis A Pérez Romasanta, Teresa L Ramos, Rebeca Ortega, Javier Borrajo, Luis A Corchete, Concepción Rodríguez, María Díez-Campelo, Luis I Sánchez-Abarca, María-Consuelo Del Cañizo, Fermín Sánchez-Guijo
Bone marrow-mesenchymal stromal cells are precursors of adipocytes and osteoblasts and key regulators of hematopoiesis. Irradiation is widely used in conditioning regimens. Despite mesenchymal stromal cells are radio-resistant, the effects of low-dose irradiation on their behavior have not been extensively explored. Our aim was to evaluate the effect of 2.5 Gy on mesenchymal stromal cells. Cells from 25 healthy donors were either irradiated or not (the latter were used as controls). Cells were characterized following ISCT criteria, including in vitro differentiation assays...
November 16, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29154466/%C3%AE-fosb-regulates-rosiglitazone-induced-milk-fat-synthesis-and-cell-survival
#10
Xuefeng Wei, Hui Li, Guangwei Zhao, Jiameng Yang, Lihui Li, Yongzhen Huang, Xianyong Lan, Yun Ma, Huiling Zheng, Hong Chen
Rosiglitazone induces adipogenesis in adipocyte and regulates cell survival and differentiation in number of cell types. However, whether PPARγ regulates the synthesis of milk fat and cell survival in goat mammary gland remains unknown. Rosiglitazone strongly enhanced cellular triacylglycerol content and accumulation of lipid droplet in goat mammary epithelial cells (GMEC). Furthermore, ΔFosB decreased the expression of PPARγ at both mRNA and protein levels, and rosiglitazone-induced milk fat synthesis was abolished by ΔFosB overexpression...
November 20, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29153558/novel-indole-and-triazole-based-hybrid-molecules-exhibit-potent-anti-adipogenic-and-antidyslipidemic-activity-by-activating-wnt3a-%C3%AE-catenin-pathway
#11
Sujith Rajan, Surendra Puri, Durgesh Kumar, Madala Hari Babu, Kripa Shankar, Salil Varshney, Ankita Srivastava, Abhishek Gupta, M Sridhar Reddy, Anil N Gaikwad
Obesity and dyslipidemia is the two facet of metabolic syndrome, which needs further attention. Recent studies indicate triazole and indole derivatives have remarkable anti-obesity/antidyslipidemic activity. To harness the above-mentioned potential, a series of novel triazole clubbed indole derivatives were prepared using click chemistry and evaluated for anti-adipogenic activity. Based on the structure-activity relationship, essential functional groups which potentiate anti-adipogenic activity were identified...
October 16, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29153512/dose-and-type-dependent-effects-of-long-chain-fatty-acids-on-adipogenesis-and-lipogenesis-of-bovine-adipocytes
#12
Chen Yanting, Q Y Yang, G L Ma, M Du, J H Harrison, E Block
Differentiation and lipid metabolism of adipocytes have a great influence on milk performance, health, and feed efficiency of dairy cows. The effects of dietary long-chain fatty acids (FA) on adipogenesis and lipogenesis of dairy cows are often confounded by other nutritional and physiological factors in vivo. Therefore, this study used an in vitro approach to study the effect of dose and type of long-chain FA on adipogenesis and lipogenesis of bovine adipocytes. Stromal vascular cells were isolated from adipose tissue of dairy cows and induced into mature adipocytes in the presence of various long-chain FA including myristic, palmitic, stearic, oleic, or linoleic acid...
November 15, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29152131/microrna-130b-attenuates-dexamethasone-induced-increase-of-lipid-accumulation-in-porcine-preadipocytes-by-suppressing-ppar-%C3%AE-expression
#13
Shifeng Pan, Yixin Cui, Xuan Dong, Tangjie Zhang, Hua Xing
In this study, two experiments were conducted to determine the role of miR-130b in dexamethasone (DEX)-induced lipid accumulation. Porcine preadipocytes were treated with 10(-6) M DEX for 48 h to investigate effects of DEX in lipid accumulation. Next, in order to illustrate the regulatory role of miR-130b on lipid accumulation induced by DEX, miRNA scrambled control (miR-SC), miR-130b overexpression plasmid and miR-130b inhibitor were respectively transfected into porcine preadipocytes at 24 h before DEX treatment for 48 h (miR-SC-DEX, miR-130b-DEX and miR-130b-inhibitor-DEX)...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29152100/differential-regulation-of-mrnas-and-lncrnas-related-to-lipid-metabolism-in-two-pig-breeds
#14
Wanlong Huang, Xiuxiu Zhang, Ai Li, Lingli Xie, Xiangyang Miao
Long non-coding RNAs (lncRNAs) can regulate lipid metabolism and adipogenesis. However, there is little research on the role of lncRNAs in fat deposition in pig. In this study, RNA-seq technology was used to analyze the gene expression profiles of subcutaneous adipose tissue in Laiwu (LW) and Large White (LY) pigs. Then, key lncRNAs and genes associated with lipid metabolism and adipogenic differentiation were identified. Fifty four lncRNAs and 482 known mRNAs were differentially expressed in the two pig breeds...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29147909/the-role-of-the-antioxidant-protein-dj-1-in-type-2-diabetes-mellitus
#15
Daniel Eberhard, Eckhard Lammert
Type 2 diabetes mellitus (T2DM) is a worldwide escalating health disorder resulting from insulin resistance and functional loss of insulin-producing beta cells that finally cause chronically elevated blood glucose concentrations. Here we review the role of ubiquitously expressed antioxidant protein DJ-1 in the pathogenesis of T2DM. In beta cells, DJ-1 protects against oxidative stress, endoplasmic reticulum stress, and streptozotocin- and cytokine-induced stress and preserves beta cell viability and insulin secretion...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29140299/pdgfr%C3%AE-regulated-by-mir-34a-and-foxo1-promotes-adipogenesis-in-porcine-intramuscular-preadipocytes-through-erk-signaling-pathway
#16
Yun-Mei Sun, Jin Qin, Shu-Ge Liu, Rui Cai, Xiao-Chang Chen, Xiang-Ming Wang, Wei-Jun Pang
Suitable intramuscular fat (IMF) content improves porcine meat quality. The vital genes regulating IMF deposition are necessary for the selection and breeding of an IMF trait. However, the effect and mechanism of PDGFRα on IMF deposition are still unclear. Here, PDGFRα is moderately expressed in porcine longissimus dorsi muscle (LD), whereas it highly expressed in white adipose tissue (WAT). Moreover, PDGFRα-positive cells were located in the gaps of LD fibers which there were IMF adipocytes. Compared with 180-day-old and lean-type pigs, the levels of PDGFRα were much higher in one-day-old and fat-type pigs...
November 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29139087/the-role-of-reactive-oxygen-species-in-adipogenic-differentiation
#17
Danielle de Villiers, Marnie Potgieter, Melvin A Ambele, Ladislaus Adam, Chrisna Durandt, Michael S Pepper
Interest in reactive oxygen species and adipocyte differentiation/adipose tissue function is steadily increasing. This is due in part to a search for alternative avenues for combating obesity, which results from the excess accumulation of adipose tissue. Obesity is a major risk factor for complex disorders such as cancer, type 2 diabetes, and cardiovascular diseases. The ability of mesenchymal stromal/stem cells (MSCs) to differentiate into adipocytes is often used as a model for studying adipogenesis in vitro...
November 15, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29138673/the-beneficial-effects-of-quercetin-curcumin-and-resveratrol-in-obesity
#18
REVIEW
Yueshui Zhao, Bo Chen, Jing Shen, Lin Wan, Yinxin Zhu, Tao Yi, Zhangang Xiao
Over the past two decades, obesity has been one of the major public health concerns in most countries. In the search for new molecules that could be used for the treatment of obesity, good perspectives have been opened up for polyphenols, a class of natural bioactive phytochemicals. Experimental and limited clinical trial evidence supports that some polyphenols such as quercetin, curcumin, and resveratrol have potential benefit functions on obesity treatment. This brief review focuses on the main functions of the above-named polyphenols on adipose tissue...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29138456/prep1-prevents-premature-adipogenesis-of-mesenchymal-progenitors
#19
Giorgia Maroni, Vsevolod A Tkachuk, Alexander Egorov, Marco J Morelli, Raffaele Luongo, Elena Levantini, Francesco Blasi, Maria Cristina Magli, Dmitry Penkov
Transcriptional regulators are crucial in adipocyte differentiation. We now show that the homeodomain-containing transcription factor Prep1 is a repressor of adipogenic differentiation since its down-regulation (DR) in both ex vivo bone marrow-derived mesenchymal stromal cells (MSC) and in vitro 3T3-L1 preadipocytes significantly increases their adipogenic differentiation ability. Prep1 acts at a stage preceding the activation of the differentiation machinery because its DR makes cells more prone to adipogenic differentiation even in the absence of the adipogenic inducers...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29138256/low-neonatal-plasma-n-6-n-3-pufa-ratios-regulate-offspring-adipogenic-potential-and-condition-adult-obesity-resistance
#20
Michael C Rudolph, Matthew R Jackman, David M Presby, Julie A Houck, Patricia G Webb, Ginger C Johnson, Taylor K Soderborg, Becky A de la Houssaye, Ivana V Yang, Jacob E Friedman, Paul S MacLean
Adipose tissue expansion (ATE) progresses rapidly during postnatal life, influenced by both prenatal maternal factors and postnatal developmental cues. The ratio of n-6 relative to n-3 polyunsaturated fatty acids (PUFA) is thought to regulate perinatal adipogenesis, but the cellular mechanisms and long-term effects are not well understood. We lowered the fetal and postnatal n-6/n-3 PUFA ratio exposure in wildtype offspring, under standard maternal dietary fat amounts, to test effects of low n-6/n-3 ratios on offspring adipogenesis and adipogenic potential...
November 14, 2017: Diabetes
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