Ceri Evans, Kuda Mutasa, Sandra Rukobo, Margaret Govha, Patience Mushayanembwa, Bernard Chasekwa, Florence D Majo, Naume V Tavengwa, Jonathan Broad, Christie Noble, Ethan K Gough, Paul Kelly, Claire D Bourke, Jean H Humphrey, Robert Ntozini, Andrew J Prendergast
Children who are HIV-exposed but uninfected have increased infectious mortality compared to HIV-unexposed children, raising the possibility of immune abnormalities following exposure to maternal viraemia, immune dysfunction, and co-infections during pregnancy. In a secondary analysis of the SHINE trial in rural Zimbabwe we explored biological pathways underlying infant mortality, and maternal factors shaping immune development in HIV-exposed uninfected infants. Maternal inflammation and cytomegalovirus viraemia were independently associated with infant deaths: mortality doubled for each log10 rise in maternal C-reactive protein (adjusted hazard ratio (aHR) 2...
April 17, 2024: Nature Communications