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Brunner's Gland

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https://www.readbyqxmd.com/read/28408987/saving-from-unnecessary-pancreaticoduodenectomy-brunner-s-gland-hamartoma-case-report-on-a-rare-duodenal-lesion-and-exhaustive-literature-review
#1
Andrea Peloso, Jacopo Viganò, Alessandro Vanoli, Tommaso Dominioni, Sandro Zonta, Dario Bugada, Carlo Maria Bianchi, Francesco Calabrese, Ilaria Benzoni, Marcello Maestri, Paolo Dionigi, Lorenzo Cobianchi
INTRODUCTION: Brunner's gland hamartoma (BGH) is an infrequently encountered, benign, polypoid proliferation of Brunner's glands. Usually these lesions are asymptomatic, just only occasionally presenting with duodenal obstruction or bleeding signs and mimicking a tumoral lesion. CASE PRESENTATION: A 72-year-old male, referred for recurrent vomiting and epigastralgia, was investigated and all preoperative findings were suggestive of a tumour of the duodenum. During the scheduled pancreaticoduodenectomy a mass, resultant to a polyp, was palpatory felt inside the duodenum and then successfully and completely resected through a duodenotomy avoiding surgical overtreatment and connected postoperative morbidities...
May 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28331876/giant-brunner-s-gland-hamartoma-as-a-cause-of-iron-deficiency-anemia
#2
Manraj Khosla, Farhoud Khosravi, James Cashman, Ananya Das
No abstract text is available yet for this article.
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28299229/a-giant-brunneroma-causing-gastrointestinal-bleeding-and-severe-anemia-requiring-transfusion-and-surgery
#3
Nicola C Frenkel, Miangela M Laclé, Inne H M Borel Rinkes, Izaak Q Molenaar, Jeroen Hagendoorn
Brunner's gland hamartoma, also called hyperplasia, adenoma, and Brunneroma, is an extremely rare benign proliferative lesion of Brunner's glands in the duodenum. While being mostly small and asymptomatic, they can result in gastrointestinal bleeding and obstruction. We report the case of a 54-year-old man presenting with melena and severe anemia requiring blood transfusion. CT scans showed a large mass of 8 cm in diameter, presumably arising in the duodenum. Endoscopic biopsies were not conclusive. As we were unable to determine the nature of the mass preoperatively and due to the severe symptoms, its size, and the uncertain malignant potential, a classic Whipple procedure was performed...
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/28275018/brunner-s-gland-hamartoma-a-rare-cause-of-iron-deficiency-anaemia-and-report-of-an-adapted-colonic-polyp-resection-technique
#4
Stephanie Judd, Suhag Patel, Edi Levi, Fadi Antaki
A man aged 65 years presented with symptomatic anaemia without overt gastrointestinal bleeding. An oesophagogastroduodenoscopy (EGD) was performed and he was found to have a large ulcerated pedunculated Brunner's gland hamartoma in the duodenal bulb. The polyp was resected using snare cautery in forward and retroflexed positions. Colonoscopy was also performed and a few diminutive polyps were resected. A year later, the patient returned for a surveillance EGD, and no residual polyp was noted. Haemoglobin and iron studies normalised within a few months after polypectomy, with resolution of symptoms...
March 8, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28258566/aquaporins-and-gland-secretion
#5
Christine Delporte
Aquaporins (AQPs ) are expressed in most exocrine and endocrine secretory glands. Consequently, summarizing the expression and functions of AQPs in secretory glands represents a daunting task considering the important number of glands present in the body, as well as the number of mammalian AQPs - thirteen. The roles played by AQPs in secretory processes have been investigated in many secretory glands. However, despite considerable research, additional studies are clearly needed to pursue our understanding of the role played by AQPs in secretory processes...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28203131/brunner-s-gland-adenoma-a-rare-cause-of-gastrointestinal-bleeding-case-report-and-systematic-review
#6
Michele Sorleto, Annette Timmer-Stranghöner, Helge Wuttig, Oliver Engelhard, Carsten Gartung
Brunner's gland adenoma is an extremely rare benign small bowel neoplasm, often discovered incidentally during upper gastrointestinal endoscopy or radiological diagnostics. In few cases, it tends to cause gastrointestinal hemorrhage or intestinal obstruction. We report here our experience with a 47-year-old woman with a Brunner's gland adenoma of more than 6 cm in size, located in the first part of the duodenum and causing gastrointestinal bleeding. Initially, we performed a partial endoscopic resection using endoloop and snare alternatively to prevent severe bleeding...
January 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/27994010/successful-surgical-excision-of-a-massive-symptomatic-partially-obstructing-brunner-s-gland-hamartoma-a-case-report
#7
Khortnal Delvecchio, Susan Seman
Brunner gland function within the duodenal epithelium is secretion of alkaline mucin to counteract acidic chyme. These glands may grow beyond the duodenal wall to become hamartomas. Rarely, they become large enough to cause obstructive symptoms in the upper gastrointestinal tract. We report a case of one of the largest lesions identified in the literature causing obstruction symptoms. A previously asymptomatic 65-year-old gentleman presented to the emergency department with a single-day history of colicky abdominal pain, cramping and vomiting...
December 18, 2016: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/27836826/brunner-s-gland-hyperplasia-causing-gastric-outlet-obstruction-in-a-3-year-old-child
#8
Lucy Henderson, Cathy Richards, Anne Willmott, Haitham Dagash
No abstract text is available yet for this article.
November 11, 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27739441/non-ampullary-duodenal-carcinomas-clinicopathologic-analysis-of-47-cases-and-comparison-with-ampullary-and-pancreatic-adenocarcinomas
#9
Yue Xue, Alessandro Vanoli, Serdar Balci, Michelle M Reid, Burcu Saka, Pelin Bagci, Bahar Memis, Hyejeong Choi, Nobuyike Ohike, Takuma Tajiri, Takashi Muraki, Brian Quigley, Bassel F El-Rayes, Walid Shaib, David Kooby, Juan Sarmiento, Shishir K Maithel, Jessica H Knight, Michael Goodman, Alyssa M Krasinskas, Volkan Adsay
Literature on non-ampullary-duodenal carcinomas is limited. We analyzed 47 resected non-ampullary-duodenal carcinomas. Histologically, 78% were tubular-type adenocarcinomas mostly gastro-pancreatobiliary type and only 19% pure intestinal. Immunohistochemistry (n=38) revealed commonness of 'gastro-pancreatobiliary markers' (CK7 55, MUC1 50, MUC5AC 50, and MUC6 34%), whereas 'intestinal markers' were relatively less common (MUC2 36, CK20 42, and CDX2 44%). Squamous and mucinous differentiation were rare (in five each); previously, unrecognized adenocarcinoma patterns were noted (three microcystic/vacuolated, two cribriform, one of comedo-like, oncocytic papillary, and goblet-cell-carcinoid-like)...
February 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27737521/giant-brunner-s-gland-hamartoma-of-the-duodenal-bulb-presenting-with-upper-gastrointestinal-bleeding-and-obstruction
#10
Ju Hyoung Lee, Kyeong Min Jo, Tae Oh Kim, Jong Ha Park, Seung Hyun Park, Jae Won Jung, So Chong Hur, Sung Yeun Yang
Brunner's gland hamartomas are small benign lesions that are most commonly found in the bulb of the duodenum. They are very uncommon, and most are found incidentally during upper gastrointestinal series or esophagogastroduodenoscopy. The lesions tend to be asymptomatic, but patients may present with symptoms of duodenal obstruction or hemorrhage secondary to ulceration. Histologically, a Brunner's gland hamartoma consists of the components of Brunner's gland cells, as well as glandular, adipose and muscle cells...
November 2016: Clinical Endoscopy
https://www.readbyqxmd.com/read/27579190/endoscopic-resection-of-a-pedunculated-brunner-s-gland-hamartoma-of-the-duodenum
#11
Masaya Iwamuro, Takehiro Tanaka, Satoko Ando, Tatsuhiro Gotoda, Hiromitsu Kanzaki, Seiji Kawano, Yoshiro Kawahara, Hiroyuki Okada
A 68-year-old Japanese woman presented with a solitary pedunculated polyp in the duodenum. Endoscopic ultrasonography showed multiple cystic structures in the polyp. The polyp was successfully resected by endoscopic snare polypectomy and pathologically diagnosed as Brunner's gland hamartoma. Because hamartomatous components were not identified in the stalk of the polyp, we speculate that the stalk developed from traction of the normal duodenal mucosa. When a solitary, pedunculated polyp with cystic structure within the submucosa is found in the duodenum, Brunner's gland hamartoma should be considered in the differential diagnosis, despite the rarity of the disease...
2016: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/27542128/glp-1-induces-barrier-protective-expression-in-brunner-s-glands-and-regulates-colonic-inflammation
#12
Claus H Bang-Berthelsen, Thomas L Holm, Charles Pyke, Lotte Simonsen, Rolf Søkilde, Flemming Pociot, R Scott Heller, Lasse Folkersen, Peter H Kvist, Malene Jackerott, Jan Fleckner, Mogens Vilién, Lotte B Knudsen, Anders Heding, Klaus S Frederiksen
BACKGROUND: Beneficial roles for glucagon-like peptide 1 (GLP-1)/GLP-1R signaling have recently been described in diseases, where low-grade inflammation is a common phenomenon. We investigated the effects of GLP-1 in Brunner's glands and duodenum with abundant expression of GLP-1 receptors, as well as GLP-1 effect on colonic inflammation. METHODS: RNA from Brunner's glands of GLP-1R knockout and wild-type mice were subjected to full transcriptome profiling. Array results were validated by quantitative reverse transcription polymerase chain reaction in wild-type mice and compared with samples from inflammatory bowel disease (IBD) patients and controls...
September 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27454489/discrimination-of-rat-brunner-s-gland-carbohydrate-antigens-by-site-specific-monoclonal-antibodies
#13
Tomoyuki Chimuro, Hiroyuki Kuroyama, Yukinobu Goso, Kazuhiko Ishihara, Makoto Kurihara
Mucus produced and secreted by gastrointestinal mucosa contains various types of mucins equipped with unique sugar chains considered to play critical roles in protecting mucous membranes; therefore, the identification and verification of mucin sugar chains is important for understanding the underlying mechanisms. In our previous work, we generated three monoclonal antibodies (mAbs), RGM22, RGM26, and RGM42, which recognize sugar chains in rat gastric mucin. Here, we immunohistochemically analyzed the rat gastrointestinal mucosa and found that the antigens recognized by RGM22 and RGM42 were expressed in the rat antrum and Brunner's glands, whereas that recognized by RGM26 was detected in the antrum, but rarely in Brunner's glands...
September 2, 2016: Carbohydrate Research
https://www.readbyqxmd.com/read/27426650/laparoscopic-treatment-of-a-brunner-s-gland-hamartoma-a-case-report
#14
Lisa Santy, Johan Fierens, Lieven Dedrye
Background Brunner's gland hyperplasia is a rare benign tumour and occurs most frequently in the upper part of the duodenum, mostly in the fifth or the sixth decade. Pathogenesis is still unknown. Symptoms are mostly absent, but larger lesions can cause gastric outlet obstruction or bleeding. Biopsies are necessary for differential diagnosis and to rule out cancerous changes. Mostly a resection is required. Methods A case report of a symptomatic Brunneroma is described with a review of the literature. RESULTS: A 72-year-old female presented with melena due to a post-pyloric Brunneroma...
April 21, 2016: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/27123125/brunner-s-gland-cyst-in-combination-with-gastrointestinal-stromal-tumor-a-case-report
#15
Xiqian Huo, Jishu Wei, Xinchun Liu, Junli Wu, Wentao Gao, Qiang Li, Kuirong Jiang, Cuncai Dai, Y I Miao
Brunner's gland cysts are rare benign lesions that are mainly observed in the first and the second regions of the duodenum. Patients with Brunner's gland cyst demonstrate no specific symptoms. The present study reports the case of a patient with Brunner's gland cyst located in the duodenum in combination with a gastrointestinal stromal tumor (GIST) in the same region. To the best of our knowledge, the present study reports the first case of Brunner's gland cyst with GIST. A 58-year-old female patient was referred to Tianchang Hospital of Traditional Chinese Medicine (Tianchang, China) with a one-month history of upper abdominal discomfort, diarrhea and recurrent vomiting following the intake of food...
May 2016: Oncology Letters
https://www.readbyqxmd.com/read/27055413/brunner-s-gland-hamartoma-a-cause-of-the-double-duct-sign
#16
M Kostalas, P Jackson, N Karanjia
Introduction Brunner's glands are submucosal glands found in the duodenum. Proliferation of these glands can lead to the formation of Brunner's gland hamartomas (BGHs), which are uncommon, asymptomatic and usually found incidentally. They are predominantly benign lesions, but instances of malignant transformation have been reported. Case History We describe a rare case in which a periampullary lesion was causing biliary obstruction on a background of weight loss, and was associated with dilatation of the common bile duct and pancreatic duct on computed tomography and magnetic resonance imaging...
July 2016: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/26965842/analysis-of-biopsies-from-duodenal-bulbs-of-all-endoscopy-patients-increases-detection-of-abnormalities-but-has-a-minimal-effect-on-diagnosis-of-celiac-disease
#17
Samantha A Stoven, Rok Seon Choung, Alberto Rubio-Tapia, Imad Absah, Dora M Lam-Himlin, Lucinda A Harris, Saowanee Ngamruengphong, Maria I Vazquez Roque, Tsung-Teh Wu, Joseph A Murray
BACKGROUND & AIMS: In patients with positive results from serologic tests for celiac disease, analysis of tissues samples from the duodenal bulb, in addition to those from other parts of the small bowel, might increase the diagnostic yield. However, biopsies are not routinely collected from the duodenal bulb due to concerns that villous atrophy detected there could be caused by other disorders (Brunner's glands or peptic duodenitis, gastric metaplasia, shorter villi, or lymphoid follicles)...
March 7, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/26811610/approach-to-the-endoscopic-resection-of-duodenal-lesions
#18
REVIEW
Jonathan P Gaspar, Edward B Stelow, Andrew Y Wang
Duodenal polyps or lesions are uncommonly found on upper endoscopy. Duodenal lesions can be categorized as subepithelial or mucosally-based, and the type of lesion often dictates the work-up and possible therapeutic options. Subepithelial lesions that can arise in the duodenum include lipomas, gastrointestinal stromal tumors, and carcinoids. Endoscopic ultrasonography with fine needle aspiration is useful in the characterization and diagnosis of subepithelial lesions. Duodenal gastrointestinal stromal tumors and large or multifocal carcinoids are best managed by surgical resection...
January 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26809626/-endoscopic-resection-of-sporadic-non-ampullary-duodenal-neoplasms-a-single-center-study
#19
Yoon Jeong Nam, Si Hyung Lee, Kyeong Ok Kim, Byung Ik Jang, Tae Nyeun Kim, Yong Jin Kim
BACKGROUND/AIMS: Sporadic non-ampullary duodenal neoplasms are rare and optimal treatment for these lesions remains undefined. Endoscopic resection of duodenal neoplasms is widely used recently and it is an alternative treatment strategy to surgical excision. This study aimed to evaluate the safety and efficacy of endoscopic resection of duodenal neoplasms and to determine its outcomes. METHODS: Patients who underwent endoscopic resection for non-ampullary duodenal neoplasms between January 2005 and December 2014 were analyzed retrospectively...
January 25, 2016: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/26805631/large-brunner-s-gland-hamartoma-with-annular-stricture-causing-gastric-outlet-obstruction
#20
LETTER
In Tae Hwang, Young Bum Cho, Dong Eun Park, Keum Ha Choi, Tae Hyeon Kim
No abstract text is available yet for this article.
March 2016: Korean Journal of Internal Medicine
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