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pneumococcus and serotype 3 and infection

Rajendra-Prasad Janapatla, Chyi-Liang Chen, Mei-Hua Hsu, Wan-Ting Liao, Cheng-Hsun Chiu
PURPOSE: Pneumococcal virulence protein-based vaccines can provide serotype-independent protection against pneumococcal infections. Many studies, including clinical observational studies on Thomsen-Friedenrich antigen exposure and haemolytic uremic syndrome, defined the role of neuraminidases NanA, NanB and NanC in host-pneumococcus interaction. Since neuraminidases are major virulence proteins, they are potential targets for both vaccines and small molecule inhibitors. Here we explored the utility of three neuraminidases as protein vaccine antigens to generate neutralizing antibodies and to increase survival following pneumococcal infections...
March 20, 2018: Journal of Medical Microbiology
Celestine Aho, Audrey Michael, Mition Yoannes, Andrew Greenhill, Peter Jacoby, John Reeder, William Pomat, Gerard Saleu, Pioto Namuigi, Suparat Phuanukoonnon, Heidi Smith-Vaughan, Amanda J Leach, Peter Richmond, Deborah Lehmann
Streptococcus pneumoniae is a leading cause of pneumonia, the most common cause of childhood death. Papua New Guinean children experience high rates of nasopharyngeal pneumococcal colonization within weeks of birth, predisposing them to pneumococcal disease. In a trial to determine the safety and immunogenicity of early infant vaccination with 7-valent pneumococcal conjugate vaccine (7vPCV), we investigated the impact of early schedules on pneumococcal carriage. Infants were randomized at birth to receive 7vPCV in a 0-1-2-month (n = 101) or a 1-2-3-month (n = 105) schedule or no 7vPCV (n = 106)...
December 2016: Vaccine Reports
María E Toledo, Maria F Casanova, Nivaldo Linares-Pérez, Dagmar García-Rivera, Gilda Toraño Peraza, Indira Barcos Pina, Martha Montes de Oca, Laura M Rodriguez-Noda, Mayelín Mirabal, Beatriz Paredes, Dunia M Chávez Amaro, Darielys Santana Mederos, Yury Valdés-Balbín, Vicente Verez-Bencomo
BACKGROUND: A new vaccine candidate against pneumococcus is being developed in Cuba, and it is a priority of the national health system. There is limited information on nasopharyngeal colonization burden, though it is essential for monitoring the impact of the vaccine. The study aims to estimate the prevalence of nasopharyngeal colonization in children 2-18 months of age and identify circulating serotypes, antimicrobial resistance and its association with selected risk factors. METHODS: A cross-sectional study was conducted between October and December 2013 in Cienfuegos municipality...
January 2017: Pediatric Infectious Disease Journal
Marta Inês Cazentini Medeiros, Bento Vidal de Moura Negrini, Jorgete Maria E Silva, Samanta Cristine Grassi Almeida, Maria Luiza Leopoldo, Silva Guerra, Denise de Andrade
INTRODUCTION: Infections caused by Streptococcus pneumoniae (pneumococcus) still represent a challenge for health systems around the world. OBJECTIVE: The objective of this study was to assess microbiological and clinical aspects in hospitalized patients with invasive pneumococcus disease between 1998 and 2013. MATERIALS AND METHODS: This was a retrospective study that analyzed the results of pneumococcus identification, serotyping, and susceptibility testing found in the Adolfo Lutz Institute databank...
May 2016: Brazilian Journal of Infectious Diseases
Sara Tomczyk, Carmen S Arriola, Bernard Beall, Alvaro Benitez, Stephen R Benoit, LaShondra Berman, Joseph Bresee, Maria da Gloria Carvalho, Amanda Cohn, Kristen Cross, Maureen H Diaz, Louise K Francois Watkins, Ryan Gierke, Jose E Hagan, Aaron M Harris, Seema Jain, Lindsay Kim, Miwako Kobayashi, Stephen Lindstrom, Lesley McGee, Meredith McMorrow, Benjamin L Metcalf, Matthew R Moore, Iaci Moura, W Allan Nix, Edith Nyangoma, M Steven Oberste, Sonja J Olsen, Fabiana Pimenta, Christina Socias, Kathleen Thurman, Jessica Waller, Stephen H Waterman, Matthew Westercamp, Melinda Wharton, Cynthia G Whitney, Jonas M Winchell, Bernard Wolff, Curi Kim
BACKGROUND: From January 2014-July 2014, more than 46 000 unaccompanied children (UC) from Central America crossed the US-Mexico border. In June-July, UC aged 9-17 years in 4 shelters and 1 processing center in 4 states were hospitalized with acute respiratory illness. We conducted a multistate investigation to interrupt disease transmission. METHODS: Medical charts were abstracted for hospitalized UC. Nonhospitalized UC with influenza-like illness were interviewed, and nasopharyngeal and oropharyngeal swabs were collected to detect respiratory pathogens...
July 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
D S Vorobiev, I B Semenova, Yu V Volokh, E E Romanenko, A P Baturo, N A Mikhailova
AIM: Study protective activity of protein-containing antigens of pneumococcus, obtained from serotypes 6B, 10A, 14, 19F, 23F and 36R, against infection with heterologous strains of S. pneumoniae. MATERIALS AND METHODS: S. pneumoniae strains of serotypes 3, 6B, 10A, 14, 19F, 23F and 36R, obtained from the collection of pneumococcus strains of Mechnikov RIVS, were used in the study. Protein-containing antigens of S. pneumoniae were isolated by acetone precipitations of supernatant fraction of culture medium...
November 2015: Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii
Chiara Azzari, Martina Cortimiglia, Francesco Nieddu, Maria Moriondo, Giuseppe Indolfi, Romano Mattei, Massimo Zuliani, Beatrice Adriani, Roberto Degl'Innocenti, Guglielmo Consales, Donatella Aquilini, Giancarlo Bini, Massimo Edoardo Di Natale, Clementina Canessa, Silvia Ricci, Elisa de Vitis, Giusi Mangone, Angela Bechini, Paolo Bonanni, Angela Pasinato, Massimo Resti
The 7-valent pneumococcal conjugate vaccine (PCV7) produced a significant herd protection in unvaccinated adult population mostly because of pneumococcus carriage decrease in vaccinated children. It is not known if the 13-valent pneumococcal vaccine can give similar effect on adults. Aims of the work were to evaluate whether the 6 additional serotypes are present in nasopharynx of children and serotype distribution in invasive pneumococcal infections (IPD) in adults. Realtime-PCR was used to evaluate pneumococcal serotypes in adults with confirmed IPD and in nasopharyngeal swabs (NP) from 629 children not vaccinated or vaccinated with PCV7 and resident in the same geographical areas...
2016: Human Vaccines & Immunotherapeutics
Ellen Heinsbroek, Terence Tafatatha, Christina Chisambo, Amos Phiri, Oddie Mwiba, Bagrey Ngwira, Amelia C Crampin, Jonathan M Read, Neil French
The prevalence of Streptococcus pneumoniae (pneumococcus) carriage is higher in adults who are infected with human immunodeficiency virus (HIV) than in adults who are not. We hypothesized that infants exposed to HIV become carriers of nasopharyngeal pneumococcus earlier and more frequently than infants who are not exposed to HIV. We compared infant pneumococcal acquisition by maternal HIV status and household exposure in Karonga District, Malawi, in 2009-2011, before the introduction of pneumococcal conjugate vaccine...
January 1, 2016: American Journal of Epidemiology
O Ochoa-Gondar, E Figuerola-Massana, A Vila-Corcoles, C A Aguirre, C de Diego, E Satue, F Gomez, X Raga
OBJECTIVE: This study investigated incidence and serotype distribution of Streptococcus pneumoniae causing acute otitis media (AOM) in Catalonian children, evaluating vaccination effectiveness in the current era of extended valency pneumococcal conjugate vaccines (PCVs). METHODS: Population-based surveillance study that included all AOM cases with isolation of pneumococcus (from otic fluids/otorrea) identified among children ≤14 years in the region of Tarragona (Southern Catalonia, Spain) from 01/01/2007 to 31/12/2013...
December 2015: International Journal of Pediatric Otorhinolaryngology
Shabir A Madhi, Alane Izu, Marta C Nunes, Avye Violari, Mark F Cotton, Patrick Jean-Philippe, Keith P Klugman, Anne von Gottberg, Nadia van Niekerk, Peter V Adrian
BACKGROUND: Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus are all potentially pathogenic, which frequently colonize the nasopharynx (NP) prior to causing disease. We studied bacterial NP-colonization in 321 HIV-infected and 243 HIV-uninfected children vaccinated with 7-valent pneumococcal conjugate vaccine (PCV7) at 6, 10 and 14 weeks of age. METHODS: HIV-uninfected infants included those born to HIV-uninfected (HUU) and HIV-infected women (HEU); HIV-infected children with CD4+ lymphocyte ≥25% were randomized to initiate antiretroviral therapy immediately (ART-Immed) or when clinically indicated (ART-Def)...
May 28, 2015: Vaccine
Mainga Hamaluba, Rama Kandasamy, Susan Ndimah, Richard Morton, Marisa Caccamo, Hannah Robinson, Sarah Kelly, Aimee Field, Lily Norman, Emma Plested, Ben A V Thompson, Azhar Zafar, Simon A Kerridge, Rajeka Lazarus, Tessa John, Jane Holmes, Shannon N Fenlon, Katherine A Gould, Pauline Waight, Jason Hinds, Derrick Crook, Matthew D Snape, Andrew J Pollard
Using nasopharyngeal carriage as a marker of vaccine impact, pneumococcal colonization and its relation to invasive disease were examined in children, their parents, and older adults in the United Kingdom following introduction of 7-valent pneumococcal conjugate vaccine (PCV7) and prior to 13-valent pneumococcal conjugate vaccine (PCV13).A cross-sectional observational study was conducted, collecting nasopharyngeal swabs from children aged 25 to 55 months who had previously received 3 doses of PCV7, their parents, and adults aged ≥65 years...
January 2015: Medicine (Baltimore)
J-H Xu, W-J Dai, B Chen, X-Y Fan
As infection with Streptococcus pneumoniae (mainly via the mucosal route) is a leading cause of acute otitis media, sinus and bacterial pneumonia, the mucosal immunity plays an important role in the prevention of pneumococcal diseases. Therefore, intranasal vaccination may be an effective immunization strategy, but requires appropriate mucosal vaccine delivery systems. In this work, chitosan was used as a mucosal delivery system to form chitosan-PsaA nanoparticles based on ionotropic gelation methods and used to immunize BALB/c mice intranasally...
March 2015: Scandinavian Journal of Immunology
Layla K Mahdi, Tahereh Deihimi, Fatemeh Zamansani, Mario Fruzangohar, David L Adelson, James C Paton, Abiodun D Ogunniyi, Esmaeil Ebrahimie
BACKGROUND: Streptococcus pneumoniae (the pneumococcus) is the world's foremost microbial pathogen, killing more people each year than HIV, TB or malaria. The capacity to penetrate deeper host tissues contributes substantially to the ability of this organism to cause disease. Here we investigated, for the first time, functional genomics modulation of 3 pneumococcal strains (serotype 2 [D39], serotype 4 [WCH43] and serotype 6A [WCH16]) during transition from the nasopharynx to lungs to blood and to brain of mice at both promoter and domain activation levels...
2014: BMC Genomics
F Casas Maldonado, I Alfageme Michavila, V S Barchilón Cohen, J I Peis Redondo, D A Vargas Ortega
Community-acquired pneumonia is an acute respiratory infectious disease which has an incidence of 3-8 cases/1,000 inhabitants, and increases with age and comorbidities. The pneumococcus is the organism most frequently involved in community-acquired pneumonia in the adult (30-35%). Around 40% of patients with community-acquired pneumonia require hospital admission, and around 10% need to be admitted to an intensive care unit. The most serious forms of pneumococcal infection include invasive pneumococcal disease (IPD), which covers cases of bacteremia (associated or not to pneumonia), meningitis, pleuritis, arthritis, primary peritonitis and pericarditis...
September 2014: Semergen
José Portolés-Pérez, María Marques-Vidas, Juan J Picazo, Fernando González-Romo, Amós García-Rojas, Emilio Pérez-Trallero, Pedro Gil-Gregorio, Rafael de la Cámara, M Luisa Morató, Alejandro Rodríguez, José Barberán, Vicente Domínguez-Hernández, Manuel Linares-Rufo, Isabel Jimeno-Sanz, Francisco Sanz-Herrero, Javier Espinosa-Arranz, Valle García-Sánchez, María Galindo-Izquierdo, Alberto Martínez-Castelao
UNLABELLED: Invasive pneumococcal disease (IPD) is a serious problem in some risk groups: patients with stage 4 and 5 chronic kidney disease, stage 3 CKD undergoing immunosuppressive treatment, nephrotic syndrome or diabetes. These individuals are more susceptible to infections and more prone to suffering more severe and worsening symptoms. Vaccination is one of the strategies for preventing IPD, although vaccination coverage in this group at present is lower than desired. Currently, there are two vaccinations for adults...
2014: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
Sorasak Lochindarat, Jamaree Teeratakulpisarn, Boonyarat Warachit, Chulapong Chanta, Kiran Thapa, Gwendolyn L Gilbert, Yongyuth Wangroongsarb, Jean-Yves Pirçon, Melissa K Van Dyke, Yanfang Liu, William P Hausdorff
This study aimed to identify the bacterial etiology of empyema thoracis or parapneumonic pleural effusions in Thai children, with a focus on pneumococcus. This hospital-based, descriptive study included children aged < or = 16 years, diagnosed with empyema thoracis or parapneumonic pleural effusion, from whom a pleural fluid (PF) sample was taken between January 2008 and November 2009. PF and blood samples were cultured and PF samples were also tested by polymerase chain reaction (PCR) to assess whether evidence of an infection might be identified among culture-negative samples...
March 2014: Southeast Asian Journal of Tropical Medicine and Public Health
Pavinee Intakorn, Nuntigar Sonsuwan, Suwiwan Noknu, Greetha Moungthong, Jean-Yves Pirçon, Yanfang Liu, Melissa K Van Dyke, William P Hausdorff
BACKGROUND: Streptococcus pneumoniae (S. pneumoniae) and Haemophilus influenzae (H. influenzae) are considered major causes of bacterial acute otitis media (AOM) worldwide, but data from Asia on primary causes of AOM are limited. This tympanocentesis-based, multi-center, cross-sectional study assessed bacterial etiology and antimicrobial susceptibility of AOM in Thailand. METHODS: Children 3 to 59 months presenting with AOM (< 72 hours of onset) who had not received prescribed antibiotics, or subjects who received prescribed antibiotics but remained symptomatic after 48-72 hours (treatment failures), were eligible...
2014: BMC Pediatrics
Cheryl Cohen, Claire von Mollendorf, Linda de Gouveia, Nireshni Naidoo, Susan Meiring, Vanessa Quan, Vusi Nokeri, Melony Fortuin-de Smit, Babatyi Malope-Kgokong, David Moore, Gary Reubenson, Mamokgethi Moshe, Shabir A Madhi, Brian Eley, Ute Hallbauer, Ranmini Kularatne, Laura Conklin, Katherine L O'Brien, Elizabeth R Zell, Keith Klugman, Cynthia G Whitney, Anne von Gottberg
BACKGROUND: South Africa introduced 7-valent pneumococcal conjugate vaccine (PCV7) in April 2009 using a 2 + 1 schedule (6 and 14 weeks and 9 months). We estimated the effectiveness of ≥2 PCV7 doses against invasive pneumococcal disease (IPD) in human immunodeficiency virus (HIV)-infected and -uninfected children. METHODS: IPD (pneumococcus identified from a normally sterile site) cases were identified through national laboratory-based surveillance. Specimens were serotyped by Quellung or polymerase chain reaction...
September 15, 2014: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Qian Geng, Tao Zhang, Yunfang Ding, Yunzhen Tao, Yuzun Lin, Yunzhong Wang, Steven Black, Genming Zhao
BACKGROUND: Dissemination of antibiotic resistant clones is recognized as an important factor in the emergence and prevalence of resistance in pneumococcus. This study was undertaken to survey the antimicrobial susceptibility and serotypes distribution of pneumococci and to explore the circulating clones in hospitalized children in Suzhou, China. METHODS: The pneumococci were isolated from the nasopharyngeal aspirates of children less than 5 years of age admitted to Soochow-University-Affiliated-Children's-Hospital with respiratory infections...
2014: PloS One
Joon Young Song, Moon H Nahm, Hee Jin Cheong, Woo Joo Kim
BACKGROUND: Even though the pathogenicity and invasiveness of pneumococcus largely depend on capsular types, the impact of serotypes on post-viral pneumococcal pneumonia is unknown. METHODS AND FINDINGS: This study was performed to evaluate the impact of capsular serotypes on the development of pneumococcal pneumonia after preceding respiratory viral infections. Patients with a diagnosis of pneumococcal pneumonia were identified. Pneumonia patients were divided into two groups (post-viral pneumococcal pneumonia versus primary pneumococcal pneumonia), and then their pneumococcal serotypes were compared...
2014: PloS One
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