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https://www.readbyqxmd.com/read/29332027/phyllodes-tumors-of-the-breast-clinicopathological-analysis-of-106-cases-from-a-single-institution
#1
Boubacar Efared
BACKGROUND: Phyllodes tumors (PT) are uncommon biphasic tumors, accounting for less than 1% of all breast primary neoplasms. They form a wide variety of tumors ranging from benign to malignant. Several histological features are used to grade PT into 3 categories: benign (grade I), borderline (grade II) and malignant (grade III) tumors. The aim of our study was to analyse histolopathological, radiological and clinical features of PT from an experience of a single center. METHODS: It was a retrospective study including 106 patients diagnosed with phyllodes tumors on surgical specimens at the department of pathology, of Hassan II university hospital (Fez, Morocco), from 2009 to 2016...
January 10, 2018: Breast Disease
https://www.readbyqxmd.com/read/29328960/the-unusual-suspects-a-review-of-unusual-benign-and-malignant-male-breast-imaging-cases
#2
REVIEW
Victoria L Mango, Sarah Goodman, Kim Clarkin, Ralph T Wynn, Lauren Friedlander, Hanina Hibshoosh, Richard Ha
Male breast disease is uncommon. Men presenting with breast symptoms may represent unique diagnostic challenges for the radiologist, particularly if imaging findings are not classic for gynecomastia or carcinoma. In this paper we review 10 unusual male breast cases, 5 benign and 5 malignant, including the radiologic findings, differential diagnosis, pathology and management.
December 28, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/29325342/-computer-aided-diagnosis-system-of-breast-ultrasound-based-on-support-vector-machine-a-clinical-analysis
#3
Z W Chen, H M Wang, J B Wu, X Y Wang, M Lin, Y Lin, H H Zhang, B J Ten, X X Huang
Objective: To investigate the value of based on support vector machine (SVM) breast ultrasonography technology of Computer-Assisted diagnosis (CAD) for differential diagnosis of benign and malignant breast masses. Methods: Total of 143 patients who had 151 breast masses were collected in Fujian Maternity and Children Health Hospital or The Fist Affiliated Hospital of Fujian Medical University from June 2014 to December 2015. Based on pathological results as the gold standard, the diagnostic efficiency of CAD and ultrasonography were compared...
December 26, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29322559/cest-dixon-for-human-breast-lesion-characterization-at-3-t-a-preliminary-study
#4
Shu Zhang, Stephen Seiler, Xinzeng Wang, Ananth J Madhuranthakam, Jochen Keupp, Emily E Knippa, Robert E Lenkinski, Elena Vinogradov
PURPOSE: Chemical exchange saturation transfer (CEST) MRI for breast lesion characterization is promising. However, artifacts are prone to develop in breast CEST imaging as a result of strong lipid signals. The aims of the study are (i) to develop and validate the CEST-Dixon imaging sequence for simultaneous water-fat separation and B0 mapping; and (ii) use the CEST-Dixon method to characterize suspicious lesions in patients undergoing percutaneous biopsy. METHODS: The gradient-echo multi-echo Dixon acquisition is used to create fat-free CEST and B0 maps...
January 10, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29302019/implications-of-nipple-discharge-in-hong-kong-chinese-women
#5
W M Kan, C Chen, A Kwong
INTRODUCTION: There are no recent data on nipple discharge and its association with malignancy in Hong Kong Chinese women. This study reported our 5-year experience in the management of patients with nipple discharge, and our experience of mammography, ultrasonography, ductography, and nipple discharge cytology in an attempt to determine their role in the management of nipple discharge. METHODS: Women who attended our Breast Clinic in a university-affiliated hospital in Hong Kong were identified by retrospective review of clinical data from January 2007 to December 2011...
January 5, 2018: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/29299762/risk-reduction-surgery-rrs-for-tubo-ovarian-cancer-in-an-irish-gynaecological-practice-an-analysis-of-indications-and-outcomes
#6
Claire Thompson, Ciara McCormick, Waseem Kamran, Ciaran O'Riain, Lucy Norris, David Gallagher, Noreen Gleeson
BACKGROUND: High-grade serous carcinoma (HGSC) is the most common tubo-ovarian cancer. The fallopian tube harbours the precursor lesion: serous tubal intraepithelial carcinoma (STIC). Bilateral salpingo-oophorectomy is an effective risk-reducing surgical (RRS) strategy for breast cancer susceptibility gene mutation carriers (BRCAm). The value of RRS in those without defined genetic risk is unknown but these women represent a substantial cohort in prophylactic surgical practice. METHODS: This is a retrospective review of RRS at an Irish university teaching hospital...
January 3, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29285483/an-evaluation-of-ultrasound-features-of-breast-fibroadenoma
#7
Alireza Namazi, Atoosa Adibi, Mahshid Haghighi, Morteza Hashemi
Background: Breast cancer is among the most common cancers in the world. Ultrasound evaluations of breast have come into attention as an alternative route. Ultrasound features of benign lesions such as fibroadenoma can be overlapping with those in a malignant tumor. Here, we assessed the reports of breast ultrasound in patients with pathologic diagnosis of fibroadenoma. Materials and Methods: We conducted a cross-sectional study and enrolled female patients with confirmed histologic diagnosis of fibroadenoma...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29285048/erratum-follow-up-outcomes-of-benign-pathology-initially-assigned-as-breast-imaging-reporting-and-data-system-category-4a-and-3
#8
Ji Young You, Hee Jung Suh, Yunju Kim, Jae Kwan Jun, Haydee Ojeda-Fournier, Kyounglan Ko
[This corrects the article on p. 304 in vol. 20, PMID: 28970857.].
December 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29258587/association-between-mammographic-breast-density-and-histologic-features-of-benign-breast-disease
#9
Karthik Ghosh, Robert A Vierkant, Ryan D Frank, Stacey Winham, Daniel W Visscher, Vernon S Pankratz, Christopher G Scott, Kathleen Brandt, Mark E Sherman, Derek C Radisky, Marlene H Frost, Lynn C Hartmann, Amy C Degnim, Celine M Vachon
BACKGROUND: Over 40% of women undergoing breast screening have mammographically dense breasts. Elevated mammographic breast density (MBD) is an established breast cancer risk factor and is known to mask tumors within the dense tissue. However, the association of MBD with high risk benign breast disease (BBD) is unknown. METHOD: We analyzed data for 3400 women diagnosed with pathologically confirmed BBD in the Mayo Clinic BBD cohort from 1985-2001, with a clinical MBD measure (either parenchymal pattern (PP) or Breast Imaging Reporting and Data Systems (BI-RADS) density) and expert pathology review...
December 19, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29251387/utilization-of-multiple-savi-scout-surgical-guidance-system-reflectors-in-the-same-breast-a-single-institution-feasibility-study
#10
Priya H Jadeja, Victoria Mango, Sejal Patel, Lauren Friedlander, Elise Desperito, Everick Ayala-Bustamante, Ralph Wynn, Margaret Chen-Seetoo, Bret Taback, Sheldon Feldman, Richard Ha
SAVI SCOUT Surgical Guidance System has been shown to be a reliable and safe alternative to wire localization in breast surgery. This study evaluated the feasibility of using multiple reflectors in the same breast. We performed an IRB-approved, HIPAA-compliant, single-institution retrospective review of 183 patients who underwent breast lesion localization and excision using SAVI SCOUT Surgical Guidance System (Cianna Medical) between June 2015 and January 2017. We performed a subset analysis in 42 patients in whom more than one reflector was placed...
December 18, 2017: Breast Journal
https://www.readbyqxmd.com/read/29234710/polypoid-endometriosis-mimicking-invasive-cancer-in-an-obese-postmenopausal-tamoxifen-user
#11
William T Jaegle, Jason C Barnett, Bridget R Stralka, Nicole P Chappell
Background: Tamoxifen is a medication often used for the treatment and prevention of breast cancer. It is classically associated with several gynecological side effects to include a thickened endometrial stripe, increased uterine polyp formation, and an increased risk of uterine cancer. Rarely tamoxifen use has been associated with proliferation of endometriosis often severe enough to mimic a late-stage gynecologic malignancy. Case: A 62-year-old Gravida 0 postmenopausal female with a medical history of severe obesity, infertility, and preventative tamoxifen use presented for evaluation of gross hematuria...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29213007/the-value-of-lesion-size-as-an-adjunct-to-the-bi-rads-mri-2013-descriptors-in-the-diagnosis-of-solitary-breast-masses
#12
Makiko Kawai, Masako Kataoka, Shotaro Kanao, Mami Iima, Natsuko Onishi, Akane Ohashi, Rena Sakaguchi, Masakazu Toi, Kaori Togashi
PURPOSE: This study aimed to evaluate the MRI findings of breast solitary masses in diagnostic procedures to decide the appropriate category based on American College of Radiology (ACR) BI-RADS-MRI 2013, with the focus on lesion size. METHODS: A retrospective review of 2,603 consecutive breast MRI reports identified 250 pathologically-proven solitary breast masses. Dynamic-contrast enhanced images and diffusion-weighted images were performed on a 3.0/1.5 Tesla Scanner with a 16/4 channel dedicated breast coil...
December 7, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/29210533/rapid-differential-diagnosis-of-breast-microcalcification-using-targeted-near-infrared-fluorophores
#13
Min Ho Park, Wonbong Lim, Danbi Jo, Jin Seok Jung, Subin Kim, Jangho Kim, Hyo Soon Lim, Ji Shin Lee, Jung-Joon Min, Hoon Hyun
Early detection and differential diagnosis of breast microcalcifications are of significant importance in effective treatment of early breast cancer, because mineral composition of breast calcification is directly associated with different pathological states. However, applying image-based modalities for component identification in breast calcification remains challenging, because no calcification-specific contrast agent is available to distinguish between benign and malignant (type I and type II, respectively) calcifications of breast lesions...
December 6, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29208778/comparison-of-the-ultrasound-guided-tru-cut-biopsy-with-postoperative-histopathology-results-in-patients-with-breast-mass
#14
Mehmet Emin Gunes
AIM: We aimed to compare the tru-cut biopsy and postoperative pathology results of breast lesions with suspicion of malignancy. Furthermore we aimed to determine the efficacy, specificity and sensitivity of the tru-cut biopsy. METHODOLOGY: 140 patients who were operated due to breast mass following tru-cut biopsy were retrospectively evalu-ated. Patients' demographic characteristics, imaging findings, biopsy and histopathology results were compared. RESULTS: The mean age of 140 patients was 51...
November 29, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29207184/cullin%C3%A2-7-is-a-predictor-of-poor-prognosis-in-breast-cancer-patients-and-is-involved-in-the-proliferation-and-invasion-of-breast-cancer-cells-by-regulating-the-cell-cycle-and-microtubule-stability
#15
Ni Qiu, Yufang He, Siming Zhang, Xinpeng Hu, Mingsheng Chen, Hongsheng Li
Cullin 7 is the 'scaffold' of the cullin-RING-based E3 ligases which catalyze the final step of the ubiquitination cascade in eukaryotic organisms. Although one study has reported the involvement of cullin 7 in the invasion and migration of breast cancer cells without further exploration of its mechanisms, the expression of cullin 7 in breast cancer tissues and its clinical significance have not been reported. The present study evaluated cullin 7 protein expression in malignant and benign breast tissues using immunochemistry, and further analyzed the association of positive cullin 7 expression in breast cancer tissues with clinicopathological characteristics of breast cancer patients...
November 21, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29197112/invasion-in-breast-lesions-the-role-of-the-epithelial-stroma-barrier
#16
REVIEW
Emad A Rakha, Islam Miligy, Kylie L Gorringe, Michael S Toss, Andrew R Green, Stephen B Fox, Fernando C Schmitt, Puay-Hoon Tan, Gary M Tse, Sunil Badve, Thomas Decker, Anne Vincent-Salomon, David J Dabbs, Maria P Foschini, Filipa Moreno, Yang Wentao, Felipe C Geyer, Jorge S Reis-Filho, Sarah E Pinder, Sunil R Lakhani, Ian O Ellis
Despite the significant biological, behavioural and management differences between ductal carcinoma in situ (DCIS) and invasive carcinoma of the breast, they share many morphological and molecular similarities. Differentiation of these two different lesions in breast pathological diagnosis is typically based on the presence of an intact barrier between the malignant epithelial cells and stroma, namely the myoepithelial cell (MEC) layer and surrounding basement membrane (BM). Despite being robust diagnostic criteria, the identification of MECs and BM to differentiate in situ from invasive carcinoma is not always straightforward...
December 2, 2017: Histopathology
https://www.readbyqxmd.com/read/29187920/-benign-tumors-of-the-breast-in-the-department-of-senology-at-the-university-hospital-aristide-le-dantec-dakar-senegal
#17
Serigne Modou Kane Gueye, Mamour Gueye, Mariétou Thiam Coulibaly, Diana Mahtouk, Jean Charles Moreau
Introduction: This study aimed to identify the epidemiological, clinical and therapeutic features of benign tumors of the breast treated in the department of senology at the university hospital Aristide Le Dantec, Dakar. Methods: We conducted a cross-sectional, descriptive and analytical study of 220 patients treated in the Department of Senology at the University Hospital Aristide Le Dantec, Dakar over the period from 1 January 2008 to 31 December 2013. Results: 220 patients out of 984 consultants had benign tumor of the breast (22...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29187884/a-single-nucleotide-polymorphism-in-hpgd-gene-is-associated-with-prostate-cancer-risk
#18
Xiaofei Qi, Yu Wang, Jianquan Hou, Yuhua Huang
Introduction: The HPGD gene was associated with some cancers, such as colorectal, breast, prostate, and bladder. However, detailed role of 15-hydroxyprostaglandin dehydrogenase (HPGD) gene remain unclear in prostate cancer. The study was to investigate the correlation between rs8752 that located in the 3'untranslated region (UTR) of the 15-hydroxyprostaglandin dehydrogenase (HPGD) gene and prostate cancer (PCa) risk. Materials and Methods: 109 patients from the First Affiliate Hospital of Soochow University were recruited...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29183534/papillary-breast-lesions-association-with-malignancy-and-upgrade-rates-on-surgical-excision
#19
Hanh-Tam Tran, Asma Mursleen, Sahar Mirpour, Omar Ghanem, Maen J Farha
Intraductal papilloma falls under the category of benign breast mass. However, recent studies show that it can harbor occult carcinoma. The management of benign intraductal papilloma remains controversial because of its nonspecific radiologic and histological findings, as well as its association with surrounding malignant pathology. The purpose of this study is to investigate upgrade rates of a benign intraductal papilloma on surgical excision and the need for surgical excision of papillary lesions diagnosed at core needle biopsy...
November 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29169930/breast-lesion-excision-system-in-the-diagnosis-and-treatment-of-intraductal-papillomas-a-feasibility-study
#20
Laura Niinikoski, Katja Hukkinen, Marjut H K Leidenius, Anders Ståhls, Tuomo J Meretoja
OBJECTIVES: This study aims to evaluate the feasibility of Breast Lesion Excision System (BLES) in the treatment of intraductal papillomas. MATERIAL AND METHODS: All patients with a needle biopsy -based suspicion of an intraductal papilloma who consequently underwent a BLES procedure at Helsinki University Hospital between 2011 and 2016 were included in this retrospective study. The purpose of the BLES procedure was either to excise the entire lesion or in few cases to achieve better sampling...
November 14, 2017: European Journal of Surgical Oncology
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