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benign breast pathology

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https://www.readbyqxmd.com/read/28641365/ultrasonography-guided-14-gauge-core-biopsy-of-the-breast-results-of-7-years-of-experience
#1
Inha Jung, Min Jung Kim, Hee Jung Moon, Jung Hyun Yoon, Eun-Kyung Kim
Purpose: This study assessed the outcomes of ultrasound (US)-guided core needle biopsies (CNBs) of breast lesions with at least 2 years of follow-up to determine the false-negative rate and to evaluate the diagnostic accuracy of CNB. Methods: We retrospectively analyzed 13,254 consecutive US-guided 14-gauge CNBs for breast lesions. We excluded biopsies if non-malignant biopsy result was not confirmed by surgical excision or US-guided vacuum-assisted biopsy, or fewer than 2 years of follow-up data were available...
May 17, 2017: Ultrasonography
https://www.readbyqxmd.com/read/28635141/high-sensitivity-non-invasive-detection-of-calcifications-deep-inside-biological-tissue-using-transmission-raman-spectroscopy
#2
Adrian Ghita, Pavel Matousek, Nick Stone
The aim of this research was to develop a novel approach to probe non-invasively the composition of inorganic chemicals buried deep in large volume biological samples. The method is based on advanced Transmission Raman Spectroscopy (TRS) permitting chemical specific detection within a large sampling volume. The approach could be beneficial to chemical identification of the breast calcifications detected during mammographic X-ray procedures. The chemical composition of a breast calcification reflects the pathology of the surrounding tissue, malignant or benign and potentially the grade of malignancy...
June 21, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28629810/spindle-cell-lesions-of-the-breast-an-approach-to-diagnosis
#3
REVIEW
Timothy Kwang Yong Tay, Puay Hoon Tan
Spindle cell lesions of the breast are among the less common entities encountered in breast pathology. They encompass a whole spectrum of benign reactive lesions to high grade malignant neoplasms. An accurate diagnosis is important to ensure that the patient receives the appropriate management. While this group of conditions broadly share the same basic morphology of a lesion composed of spindle cells, there are often recognizable differences on histology, which coupled with ancillary studies and correlation with the clinical and imaging findings, can help one to arrive at a specific diagnosis...
May 27, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28618754/evaluation-and-comparison-of-radiologic-pathologic-findings-in-invasive-cribriform-carcinoma-of-the-breast
#4
Pınar Balci, Işıl Başara Akin, Nevin Köremezli, Merih Güray Durak, Canan Altay, Naciye Sinem Gezer, Ali İbrahim Sevinç
BACKGROUND/AIM: This study aimed to report invasive cribriform carcinoma (ICC) with radiological and histopathologic correlations. MATERIALS AND METHODS: Seventy patients with ICC were classified into two groups; pure ICC patients and patients with >50% cribriform carcinoma component were included in group 1, while patients with <50% cribriform carcinoma component were included in group 2. All patients were reviewed according to American College of Radiology (ACR) breast imaging reporting and data system (BI-RADS) lexicon of mammography (MG), ultrasonography (US), and magnetic resonance imaging (MRI)...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28607282/laparoendoscopic-single-site-adnexal-surgery-preliminary-indian-experience
#5
Smitha Balusamy, Hrishikesh P Salgaonkar, Ramya Ranjan Behera, Ashwini Bhalerao-Gandhi, Deepraj S Bhandarkar
INTRODUCTION: Laparoendoscopic single-site surgery (LESS) is an emerging technique in gynaecology. The proposed advantages of the LESS include better cosmesis and reduction in pain. We report our preliminary experience with LESS in the treatment of adnexal pathology. MATERIALS AND METHODS: After a preoperative workup, LESS was offered to 37 patients between July 2009 and April 2015. All the procedures were carried out through a 2-2.5 cm transumbilical incision using conventional laparoscopic instruments...
July 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/28600957/a-rarity-in-breast-pathology-a-male-case-of-rosai-dorfman-disease-and-literature-review
#6
BenFauzi El-Attrache, Edna Kapenhas, Jack Morgani, Tahameena Ahmed
Rosai-Dorfman Disease (RDD) is a rare disease that normally presents with bilateral cervical lymph node enlargement. Systemic symptoms of fever and weight loss may be present but patients are usually asymptomatic. This benign disease tends to regress on its own without treatment but there have been cases that required treatment with steroids or chemotherapeutic regimes. Extranodal disease in the breast is extremely rare, with only three cases identified in the male breast. The patient in this study presented with an asymptomatic right breast lump identified incidentally...
May 15, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28598832/combination-of-conventional-ultrasonography-and-virtual-touch-tissue-imaging-quantification-for-differential-diagnosis-of-breast-lesions-smaller-than-10%C3%A2-mm
#7
Shu-Pin Zhang, Zeng Zeng, Hui Liu, Ming-Hua Yao, Guang Xu, Rong Wu
OBJECTIVE: To determine the value of combining conventional ultrasonography with virtual touch tissue imaging quantification (VTIQ) for differential diagnosis of breast lesions smaller than 10 mm. METHODS: A total of 98 breast lesions smaller than 10 mm were examined by conventional ultrasound and VTIQ using a Siemens ACUSON S3000 ultrasound machine. Pathologic diagnosis was established after surgery or fine needle biopsy. RESULTS: Malignant lesions were characterized by taller-than-wide shape, poorly circumscribed margin, and marked hypoechogenicity...
June 7, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28588154/ultrasonographic-evaluation-of-palpable-breast-mass-and-correlation-with-histopathology
#8
A B Jahan, M U Ahmed, M Begum, M M Hossain, M M Rahman, J M Sarwar, M Z Hossain, F Begum, P L Saha, S Haque, M Muktadira
Breast cancer is the most common malignancy in women and the second most common cause of cancer-related mortality. The distinction by physical examination of physiologic nodularity from abnormal masses can be difficult, while the clinical differentiation of a malignant mass from a benign one is difficult; the medical as well as potential legal consequences of missing a palpable carcinoma are high. There are significant number of reported cases of false-negative findings on mammography and the great desire not to miss a malignant lesion in the early stage of disease lead to aggressive biopsy, but the biopsy rate for cancer is only 10...
April 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28583649/spindle-cell-lesions-of-the-breast-multimodality-imaging-and-clinical-differentiation-of-pathologically-similar-neoplasms
#9
REVIEW
Sean D Raj, Kevin Sweetwood, Megha M Kapoor, Karuna M Raj, Chandandeep Nagi, Karla A Sepulveda, Emily L Sedgwick
Spindle cell lesions of the breast comprise a wide-range of entities including reactive, benign and malignant proliferations. They can be pathologically challenging to differentiate as there is often immunohistochemical and morphologic similarities with characteristic spindle shaped cellular patterns. Radiological and pathological correlation is essential. Radiology detects, defines the size and extent, and assists in localizing the lesions. Pathology confirms the diagnosis and provides prognostic parameters...
May 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28580069/granulomatous-mastitis-in-a-transgender-patient
#10
Kenny Q Sam, Frederick J Severs, Lilian O Ebuoma, Nagi S Chandandeep, Emily L Sedgwick
Granulomatous mastitis is a rare and benign inflammatory condition of the breast most commonly affecting women of child-bearing age as well as patients on oral contraceptives. This condition is important to identify due to its diagnostic mimicry of malicious entities such as breast carcinoma. Clinical and radiological findings are nonspecific and may overlap with breast carcinomas, thus pathologic confirmation is often necessary for definitive diagnosis. Although cases of granulomatous mastitis have been described in cisgender females, there have been no reported cases in the transgender patient, a growing patient population with few imaging guidelines...
February 2017: Journal of Radiology Case Reports
https://www.readbyqxmd.com/read/28573464/imaging-features-of-mammary-type-myofibroblastoma-of-soft-tissue-a-case-series-with-literature-review
#11
Gokhan Kuyumcu, Brian P Rubin, Carl Winalski
Mammary-type myofibroblastoma (MTM) is a rare, benign neoplasm that is histologically identical to myofibroblastoma of the breast, but occurring in an extramammary site. The masses have been reported in superficial and deep soft tissue sites and visceral locations with the inguinal area and lower extremities are the most common. Most previous reports of MTMs have concentrated on clinical and pathological findings, with very limited information regarding imaging characteristics. Here, we describe three cases of MTM diagnosed at our institution, with a focus on imaging findings...
June 1, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28569407/agreement-between-an-automated-volume-breast-scanner-and-handheld-ultrasound-for-diagnostic-breast-examinations
#12
Richard G Barr, Robert DeVita, Stamatia Destounis, Federica Manzoni, Annalisa De Silvestri, Carmine Tinelli
OBJECTIVES: To compare the agreement and interobserver variability of diagnostic handheld ultrasound (US) and a single volume on an automated breast volume scanner (ABVS) and to determine whether there was a significant difference if the ABVS was used by a sonographer or mammographic technologist. METHODS: Ninety patients scheduled for diagnostic US examinations were randomized to either handheld US or the ABVS first. The AVBS was randomized between a sonographer and a mammographic technologist performing the study...
June 1, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28537753/radiologic-pathologic-correlation-for-benign-results-after-mri-guided-breast-biopsy
#13
Katharine D Maglione, Amie Y Lee, Kimberly M Ray, Bonnie N Joe, Ronald Balassanian
OBJECTIVE: The majority of MRI-guided breast biopsies yield benign pathology. The purpose of this article is to provide a comprehensive overview of benign pathologic entities commonly encountered at MRI-guided breast biopsy. CONCLUSION: Proper radiologic-pathologic correlation is an integral component of MRI-guided breast biopsy. Familiarity with the spectrum of MRI findings and key histopathologic features of common benign entities will enhance the radiologist's confidence in determining concordance and lead to improved patient management recommendations...
May 24, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28537667/mechanism-of-the-high-coagulation-state-of-breast-cancer-tissue-factor
#14
X-K Mi, Q-R Liu, L Zhu, M-X Sang, L-R Guo, B-E Shan
OBJECTIVE: We conducted this study to analyze the mechanism behind the high coagulation state induced by circulating plasma microparticle tissue factor (MP-TF) in patients with breast cancer. PATIENTS AND METHODS: 87 cases of breast cancer patients (10 cases of TNM stage I, 16 cases of II, 32 cases of III, 29 cases of IV; 8 cases of pathological type in situ carcinoma, 15 cases of ductal carcinoma, 64 cases of invasive cancer) were used as the observation group and 20 cases of benign breast lesions were used as the control group to compare MP-TF levels of plasma and coagulation parameters including prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB) and D-dimer body (D-D) level and NF-κB signaling pathway index including P50, p65, TAK1 and IκBα levels...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28537415/-polymastia-in-unusual-localization-during-pregnancy
#15
A Humeňanská, L Havrlentová, S Jackanin, D Žiak, M Mazur
Polymastia is a fairly well-described and not entirely uncommon developmental anomaly in embryogenesis of the breast. It occurs in the milk line, most often in the axila but may also be present outside of this area. Clinical manifestation of polymastia is due to sex hormones, especially during puberty, pregnancy and lactation. Supernumerary/ aberrant breasts can undergo the same pathological changes, such as benign and malignant, as normally positioned breasts. In our case report we present a case of a pregnant patient with axillary polymasty bilaterally with benign tumors by ultrasound, further in anal and labia majora area...
2017: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/28535624/-utilisation-of-electrical-impedance-tomography-and-or-ultrasound-and-mammography-in-breast-disease-diagnosis-a-controlled-study
#16
F Xu, M X Li, H Z Jusko, Hongchuan Jiang
Objective: To investigate the diagnostic accuracy of electrical impedance tomography (EIT) for benign and malignant breast diseases incomparison to conventional ultrasonography and mammography. Methods: A total of 121 patients with 126 breast lesions who underwent mammography ultrasonography and EIT were enrolled in the study. All of these lessions were were confirmed by pathological biopsy. The accuracy, sensitivity, specificity, positive predictive value and negative predictive value of EIT, ultrasonography and mammography were calculated with histology as the gold standard...
May 16, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28535496/the-diagnostic-challenge-of-low-grade-ductal-carcinoma-in-situ
#17
Tracy Onega, Donald L Weaver, Paul D Frederick, Kimberly H Allison, Anna N A Tosteson, Patricia A Carney, Berta M Geller, Gary M Longton, Heidi D Nelson, Natalia V Oster, Margaret S Pepe, Joann G Elmore
BACKGROUND: Diagnostic agreement among pathologists is 84% for ductal carcinoma in situ (DCIS). Studies of interpretive variation according to grade are limited. METHODS: A national sample of 115 pathologists interpreted 240 breast pathology test set cases in the Breast Pathology Study and their interpretations were compared to expert consensus interpretations. We assessed agreement of pathologists' interpretations with a consensus reference diagnosis of DCIS dichotomised into low- and high-grade lesions...
May 20, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28515964/radiologic-pathologic-correlation-acellular-dermal-matrix-alloderm-%C3%A2-used-in-breast-reconstructive-surgery
#18
Christine U Lee, Aleh Bobr, Jorge Torres-Mora
Acellular dermal matrix (ADM) such as Alloderm(®) is sometimes used in tissue reconstruction in primary and reconstructive breast surgeries. As ADM is incorporated into the native tissues, the evolving imaging findings that would correlate with varying degrees of host migration and neoangiogenesis into the matrix can be challenging to recognize. In the setting of a palpable or clinical area of concern after breast reconstructive surgery following breast cancer, confident diagnosis of a mass representing ADM rather than recurring or developing disease can be challenging...
2017: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/28512241/assessment-of-breast-cancer-risk-factors-reveals-subtype-heterogeneity
#19
Johanna Holm, Louise Eriksson, Alexander Ploner, Mikael Eriksson, Mattias Rantalainen, Jingmei Li, Per Hall, Kamila Czene
Subtype heterogeneity for breast cancer risk factors has been suspected, potentially reflecting etiological differences and implicating risk prediction. However, reports are conflicting regarding presence of heterogeneity for many exposures. To examine subtype heterogeneity across known breast cancer risk factors, we conducted a case-control analysis of 2,632 breast cancers and 15,945 controls in Sweden. Molecular subtype was predicted from pathology-record derived immunohistochemistry markers by a classifier trained on PAM50 subtyping...
May 16, 2017: Cancer Research
https://www.readbyqxmd.com/read/28511385/intra-operative-diagnosis-of-breast-lesions-by-imprint-cytology-and-frozen-section-with-histopathological-correlation
#20
Asha Mahadevappa, Thattamparambil Gopalakrishnan Nisha, Gubbanna V Manjunath
INTRODUCTION: The most common malignant tumour among women is breast carcinoma. Early lesions of the breast including carcinoma are potentially curable if treated properly in the era of breast conservative therapy. For this purpose different diagnostic strategies are in practice. Intra operative Imprint Cytology (IC) and Frozen Section (FS) have a role in spite of the intense recognition of aspiration cytology in the following settings: inconclusive cytological/core biopsy findings; for evaluation of lumpectomy margins and intra operative nodal status...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
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