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https://www.readbyqxmd.com/read/28515964/radiologic-pathologic-correlation-acellular-dermal-matrix-alloderm-%C3%A2-used-in-breast-reconstructive-surgery
#1
Christine U Lee, Aleh Bobr, Jorge Torres-Mora
Acellular dermal matrix (ADM) such as Alloderm(®) is sometimes used in tissue reconstruction in primary and reconstructive breast surgeries. As ADM is incorporated into the native tissues, the evolving imaging findings that would correlate with varying degrees of host migration and neoangiogenesis into the matrix can be challenging to recognize. In the setting of a palpable or clinical area of concern after breast reconstructive surgery following breast cancer, confident diagnosis of a mass representing ADM rather than recurring or developing disease can be challenging...
2017: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/28512241/assessment-of-breast-cancer-risk-factors-reveals-subtype-heterogeneity
#2
Johanna Holm, Louise Eriksson, Alexander Ploner, Mikael Eriksson, Mattias Rantalainen, Jingmei Li, Per Hall, Kamila Czene
Subtype heterogeneity for breast cancer risk factors has been suspected, potentially reflecting etiological differences and implicating risk prediction. However, reports are conflicting regarding presence of heterogeneity for many exposures. To examine subtype heterogeneity across known breast cancer risk factors, we conducted a case-control analysis of 2,632 breast cancers and 15,945 controls in Sweden. Molecular subtype was predicted from pathology-record derived immunohistochemistry markers by a classifier trained on PAM50 subtyping...
May 16, 2017: Cancer Research
https://www.readbyqxmd.com/read/28511385/intra-operative-diagnosis-of-breast-lesions-by-imprint-cytology-and-frozen-section-with-histopathological-correlation
#3
Asha Mahadevappa, Thattamparambil Gopalakrishnan Nisha, Gubbanna V Manjunath
INTRODUCTION: The most common malignant tumour among women is breast carcinoma. Early lesions of the breast including carcinoma are potentially curable if treated properly in the era of breast conservative therapy. For this purpose different diagnostic strategies are in practice. Intra operative Imprint Cytology (IC) and Frozen Section (FS) have a role in spite of the intense recognition of aspiration cytology in the following settings: inconclusive cytological/core biopsy findings; for evaluation of lumpectomy margins and intra operative nodal status...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28491908/lack-of-agreement-between-radiologists-implications-for-image-based-model-observers
#4
Juhun Lee, Robert M Nishikawa, Ingrid Reiser, Margarita L Zuley, John M Boone
We tested the agreement of radiologists' rankings of different reconstructions of breast computed tomography images based on their diagnostic (classification) performance and on their subjective image quality assessments. We used 102 pathology proven cases (62 malignant, 40 benign), and an iterative image reconstruction (IIR) algorithm to obtain 24 reconstructions per case with different image appearances. Using image feature analysis, we selected 3 IIRs and 1 clinical reconstruction and 50 lesions. The reconstructions produced a range of image quality from smooth/low-noise to sharp/high-noise, which had a range in classifier performance corresponding to AUCs of 0...
April 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28482624/shear-wave-speed-imaging-of-breast-lesions-speed-within-the-lesion-fat-to-lesion-speed-ratio-or-gland-to-lesion-speed-ratio
#5
Xiao-Long Li, Wei-Wei Ren, Hui-Jun Fu, Ya-Ping He, Qiao Wang, Li-Ping Sun, Le-Hang Guo, Bo-Ji Liu, Lin Fang, Hui-Xiong Xu
OBJECTIVE: To evaluate the diagnostic performance of shear wave speed (SWS) within the lesion, fat-to-lesion speed ratio (FLR), and gland-to-lesion speed ratio (GLR) for differentiation between benign and malignant breast lesions using a novel SWS imaging technique. METHODS: From April 2016 to June 2016, 182 breast lesions were prospectively included in the study. For each lesion, SWS-lesion, FLR, and GLR were calculated. Pathological results were used as the reference standard...
May 2, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28482623/diagnostic-value-of-contrast-enhanced-ultrasound-and-shear-wave-elastography-for%C3%A2-breast-lesions-of-sub-centimeter
#6
Li-Hua Xiang, Ming-Hua Yao, Guang Xu, Huan Pu, Hui Liu, Yan Fang, Rong Wu
BACKGROUD: Contrast-enhanced ultrasound (CEUS) and shear-wave elastography (SWE) are used for diagnostic purposes. OBJECTIVE: Investigate the diagnostic value of CEUS and SWE for breast lesions of sub-centimeter diameter. METHODS: Sixty-two patients (mean age: 49.3±12.1 years) with 66 lesions (mean diameter, 8.1±1.5 mm) were analyzed. Conventional ultrasound (US), CEUS and SWE were undertaken. Pathologic specimens were obtained through biopsy or surgery...
May 2, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28475933/surgical-implications-and-variability-in-the-use-of-the-flat-epithelial-atypia-diagnosis-on-breast-biopsy-specimens
#7
Laura S Samples, Mara H Rendi, Paul D Frederick, Kimberly H Allison, Heidi D Nelson, Thomas R Morgan, Donald L Weaver, Joann G Elmore
OBJECTIVES: Flat epithelial atypia (FEA) is a relatively new diagnostic term with uncertain clinical significance for surgical management. Any implied risk of invasive breast cancer associated with FEA is contingent upon diagnostic reproducibility, yet little is known regarding its use. MATERIALS AND METHODS: Pathologists in the Breast Pathology Study interpreted one of four 60-case test sets, one slide per case, constructed from 240 breast biopsy specimens. An electronic data form with standardized diagnostic categories was used; participants were instructed to indicate all diagnoses present...
May 3, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28470744/mri-guided-breast-interventions
#8
Anika L McGrath, Elissa R Price, Peter R Eby, Habib Rahbar
Magnetic resonance imaging (MRI)-guided interventions, including biopsies and wire localizations, are fundamental to any breast imaging practice due to the high sensitivity but limited specificity of breast MRI. The basic steps of MRI-guided biopsies are similar regardless of the vendor or platform, and technical considerations include approach planning, patient preparation and positioning, lesion targeting, and directional sampling using a vacuum-assisted biopsy technique. Unique challenges related to MRI-guided biopsies include vanishing lesions due to contrast washout, obscuration of the biopsy site due to susceptibility artifacts, and limited access to posteromedial lesions...
May 4, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28454081/expression-characteristic-of-cxcr1-in-different-breast-tissues-and-the-relevance-between-its-expression-and-efficacy-of-neo-adjuvant-chemotherapy-in-breast-cancer
#9
Miao-Qun Xue, Jun Liu, Jian-Feng Sang, Lei Su, Yong-Zhong Yao
OBJECTIVE: To investigate chemokine receptor CXCR1 expression characteristic in different breast tissues and analyze the relationship between CXCR1 expression changes in breast cancer tissue and efficacy of neo-adjuvant chemotherapy. RESULTS: Chemokine receptor CXCR1 was lowly expressed in normal breast tissues and breast fibroadenoma, but highly expressed in breast cancer. It was significantly correlated with pathological stage, tumor cell differentiation, and lymph node metastasis (P < 0...
April 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28438672/the-management-strategy-of-benign-solitary-intraductal-papilloma-on-breast-core-biopsy
#10
Dayoung Ko, Eunyoung Kang, So Yeon Park, Sun Mi Kim, Mijung Jang, Bo La Yun, Sumin Chae, Yerang Jang, Hye Jin Kim, Sung-Won Kim, Eun-Kyu Kim
BACKGROUND: Intraductal papilloma (IDP) is well-known as one of the common benign breast lesions requiring excision. However, treatment of IDP without atypia is controversial. The aim of our study was to determine the proper management of solitary IDP by core needle biopsy (CNB). PATIENTS AND METHODS: We retrospectively reviewed patients with solitary IDP confirmed by CNB from March 2003 to March 2015. We collected data about final pathology after excision, as well as clinical, histologic, and radiologic findings at initial diagnosis...
April 1, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28430555/beyond-wires-and-seeds-reflector-guided-breast-lesion-localization-and-excision
#11
Victoria L Mango, Ralph T Wynn, Sheldon Feldman, Lauren Friedlander, Elise Desperito, Sejal N Patel, Ameer Gomberawalla, Richard Ha
Purpose To evaluate outcomes of Savi Scout (Cianna Medical, Aliso Viejo, Calif) reflector-guided localization and excision of breast lesions by analyzing reflector placement, localization, and removal, along with target excision and rates of repeat excision (referred to as re-excision). Materials and Methods A single-institution retrospective review of 100 women who underwent breast lesion localization and excision by using the Savi Scout surgical guidance system from June 2015 to May 2016 was performed. By using image guidance 0-8 days before surgery, 123 nonradioactive, infrared-activated, electromagnetic wave reflectors were percutaneously inserted adjacent to or within 111 breast targets...
April 21, 2017: Radiology
https://www.readbyqxmd.com/read/28418338/diagnosis-of-nipple-discharge-value-of-magnetic-resonance-imaging-and-ultrasonography-in-comparison-with-ductoscopy
#12
Ravza Yılmaz, Ömer Bender, Fatma Çelik Yabul, Menduh Dursun, Mehtap Tunacı, Gülden Acunas
BACKGROUND: Pathologic nipple discharge, which is a common reason for referral to the breast imaging service, refers to spontaneous or bloody nipple discharge that arises from a single duct. The most common cause of nipple discharge is benign breast lesions, such as solitary intraductal papilloma and papillomatosis. Nevertheless, in rare cases, a malignant cause of nipple discharge can be found. AIMS: To study the diagnostic value of ultrasonography, magnetic resonance imaging, and ductoscopy in patients with pathologic nipple discharge, compare their efficacy, and investigate the importance of magnetic resonance imaging in the diagnosis of intraductal pathologies...
April 5, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28399535/17%C3%AE-estradiol-and-gonadotropin-levels-for-the-diagnosis-of-the-benign-form-of-breast-development-in-girls-aged-up-to-4-years-in-real-life-clinical-practice
#13
Martin Österbrand, Hans Fors, Kerstin Allvin, Ensio Norjavaara
BACKGROUND: Early onset of breast development in a young girl is usually a benign and isolated prepubertal condition, i.e., premature thelarche (PT), but can sometimes be progressive and the first sign of pubertal precocity (PP). Serum 17β-estradiol (17β-E2) level is a possible marker to differentiate between benign and pathological forms of breast development. We defined an upper serum 17β-E2 level for benign, "classic" PT for girls aged 9-48 months. METHODS: Serum 17β-E2 was analysed with a highly sensitive extraction radioimmunoassay (RIA)...
April 11, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28383279/accuracy-of-diffusion-kurtosis-imaging-in-characterization-of-breast-lesions
#14
Alexandra Christou, Abraham Ghiatas, Dimitrios Priovolos, Konstantia Veliou, Haralambos Bougias
OBJECTIVE: The aim of this study was to evaluate the accuracy of diffusion kurtosis in the characterization and differentiation of breast lesions. METHODS: 49 females with 53 breast lesions underwent breast MRI. The MRI magnetic field is 1.5 T, and the protocol is standard MRI sequences, dynamic sequences pre- and post-contrast agent administration and diffusion images. Diffusion kurtosis imaging (DKI) was applied as part of our standard breast MRΙ protocol. Two experienced radiologists on breast MRI, blinded to the final diagnosis, reviewed the parametric maps and placed a volume of interest on all slices including each lesion...
May 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28376591/-pathologic-changes-of-spontaneous-tumors-in-sprague-dawley-and-wistar-rats
#15
Y N He, S C Zhang, H M Zhang
Objective: To investigate the spontaneous neoplastic lesions and their incidences in Sprague-Dawley (SD) and Wistar rats, and to accumulate background data for carcinogenicity studies. Methods: One hundred and eighty SD rats and 240 Wistar rats (4-week old) , half in each sex, were used in this study. The rats were housed routinely under specific pathogen-free environment and euthanized after 104 weeks. Histopathological examination was undertaken for all animals including deaths and scheduled euthanasia. The types and incidences of spontaneous tumors were gathered statistically...
April 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28371110/computer-aided-heterogeneity-analysis-in-breast-mr-imaging-assessment-of-ductal-carcinoma-in-situ-correlating-histologic-grade-and-receptor-status
#16
Shinn-Huey S Chou, Eva C Gombos, Sona A Chikarmane, Catherine S Giess, Jagadeesan Jayender
PURPOSE: To identify breast MR imaging biomarkers to predict histologic grade and receptor status of ductal carcinoma in situ (DCIS). MATERIALS AND METHODS: Informed consent was waived in this Health Insurance Portability and Accountability Act-compliant Institutional Review Board-approved study. Case inclusion was conducted from 7332 consecutive breast MR studies from January 1, 2009, to December 31, 2012. Excluding studies with benign diagnoses, studies without visible abnormal enhancement, and pathology containing invasive disease yielded 55 MR-imaged pathology-proven DCIS seen on 54 studies...
April 3, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28370098/sonographic-findings-of-accessory-breast-tissue-in-axilla-and-related-diseases
#17
Hyo Soon Lim, Shin Jung Kim, Jang Mi Baek, Jin Woong Kim, Sang Soo Shin, Hyun Ju Seon, Suk Hee Heo
Accessory breast tissue results from failed regression of primitive mammary tissue and is most often located in the axilla. Accessory breast tissue itself is normal and should not be misdiagnosed as an abnormality. Both benign and malignant diseases that occur in the normal breast can also develop in accessory breast tissue in the axilla. In this pictorial essay, we show sonographic findings of normal accessory breast tissue in the axilla and various lesions that occur in accessory axillary breast tissue, along with other imaging findings and pathologic features...
April 3, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28370063/total-variation-based-dce-mri-decomposition-by-separating-lesion-from-background-for-time-intensity-curve-estimation
#18
Hui Liu, Yuanjie Zheng, Dong Liang, Pinpin Tang, Fuquan Ren, Lina Zhang, Weizuo Zhao
PURPOSE: This study aims to obtain the accurate time intensity curve (TIC) of a dynamic contrast-enhanced magnetic resonance image (DCE-MRI) by eliminating the normal tissue enhancement and obtaining pure lesion information. The TIC of DCE-MRI is sometimes distorted because of the influence of normal tissue. In this paper, a new tracer-kinetic modeling based on total variation (DC-TV) is proposed to address this problem by decomposing the DCE-MRI into the normal tissue image and the lesion image...
March 30, 2017: Medical Physics
https://www.readbyqxmd.com/read/28353380/characteristics-of-a-breast-pathology-consultation-practice
#19
Ellen G East, Lili Zhao, Judy C Pang, Julie M Jorns
CONTEXT: - Intradepartmental consultation is a routine practice commonly used for new diagnoses. Expert interinstitutional case review provides insight into particularly challenging cases. OBJECTIVE: - To investigate the practice of breast pathology consultation at a large tertiary care center. DESIGN: - We reviewed breast pathology cases sent for private consultation and internal cases reviewed by multiple pathologists at a tertiary center...
April 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28351284/impact-of-breast-cancer-awareness-month-on-detection-of-breast-cancer-in-a-private-hospital
#20
Onder Karabay, Mustafa Hasbahceci, Huseyin Kadioglu
Objective Breast cancer awareness month increases public awareness in association with increased rates of screening and new diagnoses. This study aimed to evaluate the effect of breast cancer awareness month on primary diagnosis of breast cancer. Methods Asymptomatic women with the intention of breast cancer screening were included. The non-BCAM (Breast cancer awareness month) group were screened from February to September 2016 and the BCAM group during October 2016. Ultrasound and mammography were performed in all women and in those aged ≥ 40 years, respectively...
January 1, 2017: Journal of International Medical Research
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