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benign breast pathology

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https://www.readbyqxmd.com/read/29146885/mammary-phyllodes-tumour-a-15-year-multicentre-clinical-review
#1
Michael Co, Clement Chen, Julia Y Tsang, Gary Tse, Ava Kwong
AIMS: Phyllodes tumour (PT) is an uncommon fibroepithelial tumour of the breast. It has a spectrum of aggressiveness in biological behaviour with chance of local recurrence and, occasionally, metastasis. METHODS: A 15-year retrospective review from a multicentre database in Hong Kong was performed. RESULTS: Clinical and pathological records of 465 patients with 469 PTs between 1998 and 2014 were reviewed. Median age of occurrence was 44 years (range 12-86 years)...
November 16, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29137394/measuring-plasma-levels-of-three-micrornas-can-improve-the-accuracy-for-identification-of-malignant-breast-lesions-in-women-with-bi-rads-4-mammography
#2
Julia Alejandra Pezuk, Thiago Luiz Araujo Miller, José Luiz Barbosa Bevilacqua, Alfredo Carlos Simões Dornellas de Barros, Felipe Eduardo Martins de Andrade, Luiza Freire de Andrade E Macedo, Vera Aguilar, Amanda Natasha Menardo Claro, Anamaria Aranha Camargo, Pedro Alexandre Favoretto Galante, Luiz F L Reis
A BI-RADS category of 4 from a mammogram indicates suspicious breast lesions, which require core biopsies for diagnosis and have an approximately one third chance of being malignant. Human plasma contains many circulating microRNAs, and variations in their circulating levels have been associated with pathologies, including cancer. Here, we present a novel methodology to identify malignant breast lesions in women with BI-RADS 4 mammography. First, we used the miRNome array and qRT-PCR to define circulating microRNAs that were differentially represented in blood samples from women with breast tumor (BI-RADS 5 or 6) in comparison to controls (BI-RADS 1 or 2)...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29134380/radioactive-seed-localization-versus-wire-localization-for-nonpalpable-breast-lesions-a-two-year-initial-experience-at-a-large-community-hospital
#3
Lacey Stelle, Taylor Schoenheit, Allison Brubaker, Xiwei Tang, Peiyong Qu, Kimberly Cradock, Anna Higham
BACKGROUND: Radioactive seed localization (RSL) is a safe and effective alternative to wire localization (WL) for nonpalpable breast lesions. While several large academic institutions currently utilize RSL, few community hospitals have adopted this technique. OBJECTIVE: The aim of this study was to examine the experience of RSL versus WL at a large community hospital. METHODS: A retrospective chart review of patients who underwent RSL or WL for breast-conserving surgery from 1 November 2013 to 31 November 2015...
November 13, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29127495/size-and-heterologous-elements-predict-metastases-in-malignant-phyllodes-tumours-of-the-breast
#4
Valerie Cui Yun Koh, Aye Aye Thike, Nur Diyana Md Nasir, George Wai Cheong Yip, Boon Huat Bay, Puay Hoon Tan
Phyllodes tumours (PTs) of the breast are uncommon fibroepithelial neoplasms comprising 0.3-1.0% of all primary breast tumours. The majority of PTs are benign and generally well managed with surgery. However, malignant PTs, and occasionally borderline PTs, can behave in a clinically aggressive manner by metastasizing to distant organs. Although distant metastasis is rare, the prognosis of patients with metastasis is dismal as many are unresponsive to standard chemotherapy and the risk of death is high. In this study, we correlated clinicopathological parameters to survival outcomes in a cohort of patients diagnosed with malignant PTs in our institution...
November 10, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29110671/residual-microcalcifications-after-neoadjuvant-chemotherapy-for-locally-advanced-breast-cancer-comparison-of-the-accuracies-of-mammography-and-mri-in-predicting-pathological-residual-tumor
#5
Yeong Yi An, Sung Hun Kim, Bong Joo Kang
BACKGROUND: The aims of this study were to correlate residual mammographic microcalcifications after neoadjuvant chemotherapy (NAC) with pathological results and to compare the accuracy of mammography (MG) and magnetic resonance imaging (MRI) in predicting the size of residual tumors. METHODS: The imaging findings and pathological results for 29 patients with residual microcalcifications after NAC were reviewed. We compared the agreement of the measured extent of residual microcalcifications based on MG and residual enhancement based on MRI with the residual tumor size based on pathology...
November 6, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29094880/disorders-of-puberty-an-approach-to-diagnosis-and-management
#6
David A Klein, Jill E Emerick, Jillian E Sylvester, Karen S Vogt
Disorders of puberty can profoundly impact physical and psychosocial well-being. Precocious puberty is pubertal onset before eight years of age in girls and before nine years of age in boys. Patients with early isolated pubertal changes, prepubertal linear growth, and no worrisome neurologic symptoms typically have a benign pattern of development and should be monitored in the appropriate clinical context. Among patients with true precocious puberty, or full activation of the hypothalamic-pituitary-gonadal axis, most girls have an idiopathic etiology, whereas it is commonly due to identifiable pathology on imaging in boys...
November 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/29089809/coordination-of-radiologic-and-clinical-care-reduces-the-wait-time-to-breast-cancer-diagnosis
#7
E C McKevitt, C K Dingee, R Warburton, J S Pao, C J Brown, C Wilson, U Kuusk
BACKGROUND: In 2009, a Rapid Access Breast Clinic (rabc) was opened at our urban hospital. Compared with the traditional system (ts), the navigated care through the clinic was associated with a significantly shorter time to surgical consultation. Since 2009, many radiology facilities have introduced facilitated-care pathways for patients with breast pathology. Our objective was to determine if that change in diagnostic imaging pathways had eliminated the advantage in time to care previously shown for the rabc...
October 2017: Current Oncology
https://www.readbyqxmd.com/read/29080125/clinical-breast-concerns-in-low-risk-pediatric-patients-practice-review-with-proposed-recommendations
#8
Linda M Sanders, Pinky Sharma, Miriam El Madany, Alexander B King, Koren S Goodman, Alison Esteva Sanders
BACKGROUND: Fibroadenoma is overwhelmingly the most common pediatric breast lesion. Breast malignancy is quite uncommon in children, most frequently metastatic or hematological malignancy. Core biopsy has largely replaced excision for diagnosis of breast masses in adults. OBJECTIVE: The purpose of this study is two-fold: (1) compare utilization at our institution of interventional procedures vs. surgery for breast mass diagnosis in patients ≤18 years and (2) propose guidelines for breast imaging and biopsy in this population...
October 27, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29075317/multiple-oncogenic-viruses-are-present-in-human-breast-tissues-before-development-of-virus-associated-breast-cancer
#9
James S Lawson, Wendy K Glenn
BACKGROUND: Multiple oncogenic viruses including, mouse mammary tumor virus, bovine leukemia virus, human papilloma virus, and Epstein Barr virus, have been identified as separate infectious pathogens in human breast cancer. Here we demonstrate that these four viruses may be present in normal and benign breast tissues 1 to 11 years before the development of same virus breast cancer in the same patients. METHODS: We combined the data we developed during investigations of the individual four oncogenic viruses and breast cancer...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29065920/addition-of-t2-guided-optical-tomography-improves-noncontrast-breast-magnetic-resonance-imaging-diagnosis
#10
Jinchao Feng, Junqing Xu, Shudong Jiang, Hong Yin, Yan Zhao, Jiang Gui, Ke Wang, Xiuhua Lv, Fang Ren, Brian W Pogue, Keith D Paulsen
BACKGROUND: While dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) is recognized as the most sensitive examination for breast cancer detection, it has a substantial false positive rate and gadolinium (Gd) contrast agents are not universally well tolerated. As a result, alternatives to diagnosing breast cancer based on endogenous contrast are of growing interest. In this study, endogenous near-infrared spectral tomography (NIRST) guided by T2 MRI was evaluated to explore whether the combined imaging modality, which does not require contrast injection or involve ionizing radiation, can achieve acceptable diagnostic performance...
October 24, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29039725/high-risk-breast-lesions-a-machine-learning-model-to-predict-pathologic-upgrade-and-reduce-unnecessary-surgical-excision
#11
Manisha Bahl, Regina Barzilay, Adam B Yedidia, Nicholas J Locascio, Lili Yu, Constance D Lehman
Purpose To develop a machine learning model that allows high-risk breast lesions (HRLs) diagnosed with image-guided needle biopsy that require surgical excision to be distinguished from HRLs that are at low risk for upgrade to cancer at surgery and thus could be surveilled. Materials and Methods Consecutive patients with biopsy-proven HRLs who underwent surgery or at least 2 years of imaging follow-up from June 2006 to April 2015 were identified. A random forest machine learning model was developed to identify HRLs at low risk for upgrade to cancer...
October 17, 2017: Radiology
https://www.readbyqxmd.com/read/29024205/the-intact-%C3%A2-breast-lesion-excision-system-as-a-therapeutic-device-for-selected-benign-breast-lesions
#12
Miri Sklair-Levy, Shlomi Rayman, Ady Yosepovich, Andrew Zbar, David Goitein, Douglas Zippel
The aim of this paper is to evaluate our Unit's initial experience using the Intact breast lesion excision system as a therapeutic excision option for benign or borderline breast lesions, which otherwise would entail open operative excision. The study includes the first 111 patients who underwent therapeutic excision with the intact radiofrequency system between December 2012 and May 2016 performed at the Meirav Center for Breast Health, at the Chaim Sheba Medical Center, Ramat Gan Israel. The indications for the procedure included those patients who have benign, or atypical high risk lesions following a previous core needle biospy (CNB) who would have normally undergone conventional excision biopsy...
October 11, 2017: Breast Journal
https://www.readbyqxmd.com/read/29024198/mucocele-like-lesions-diagnosed-on-breast-core-biopsy-low-risk-of-upgrade-and-subsequent-carcinoma
#13
Gloria Zhang, Dana Ataya, Paulette L Lebda, Benjamin C Calhoun
Mucocele-like lesions of the breast diagnosed on core biopsy are usually excised to exclude the possibility of partial sampling of an invasive mucinous carcinoma. The goal of this study was to correlate the pathologic and radiologic features of mucocele-like lesions to determine if excision is mandatory. Over a 16 year period we identified 32 patients with mucocele-like lesions diagnosed on 27 (84%) stereotactic and 5 (16%) ultrasound-guided core biopsies. The indications for core biopsy were: calcifications in 24 (75%), a mass in 7 (22%), and a mass with calcifications in 1 (3%)...
October 11, 2017: Breast Journal
https://www.readbyqxmd.com/read/29016373/cancer-yield-of-incidental-breast-lesions-detected-on-chest-computed-tomography
#14
Terrance T Healey, Saurabh Agarwal, Ronak Patel, Lisa Ratanaprasatporn, Linda Ratanaprasatporn, Ana P Lourenco
OBJECTIVE: This study aimed to determine the cancer yield for abnormal breast findings initially identified on chest computed tomography (CT). MATERIALS AND METHODS: This institutional review board-approved, Health Insurance Portability and Accountability Act-compliant study retrospectively reviewed reports of 41,217 consecutive chest CT examinations done from January 1, 2006, to December 31, 2011, to identify those with breast findings noted in the impression of the report...
October 7, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28981408/multi-instance-multi-label-learning-for-multi-class-classification-of-whole-slide-breast-histopathology-images
#15
Caner Mercan, Selim Aksoy, Ezgi Mercan, Linda G Shapiro, Donald L Weaver, Joann G Elmore
Digital pathology has entered a new era with the availability of whole slide scanners that create high-resolution images of full biopsy slides. Consequently, the uncertainty regarding the correspondence between the image areas and the diagnostic labels assigned by pathologists at the slide level, and the need for identifying regions that belong to multiple classes with different clinical significance have emerged as two new challenges. However, generalizability of the state-of-theart algorithms, whose accuracies were reported on carefully selected regions of interest (ROI) for the binary benign versus cancer classification, to these multi-class learning and localization problems is currently unknown...
October 2, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28970859/invasive-micropapillary-carcinoma-in-axillary-ectopic-breast-and-synchronous-ductal-carcinoma-in-situ-in-the-contralateral-breast
#16
Seung Won Oh, Hyo Soon Lim, Ji Shin Lee, Sung Min Moon, Min Ho Park
The development of ectopic breast tissue is attributable to the failure of primitive mammary tissue to regress after the development of the mammary ridge, except at pectoral breast sites, and is most often evident in the axillae. Several benign and malignant breast diseases have been reported in ectopic axillary breast tissues. The most common cancerous pathology of ectopic breast tissue is invasive ductal carcinoma. Ectopic breast cancer presenting with simultaneous primary cancer of the pectoral breast is extremely rare...
September 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28970857/follow-up-outcomes-of-benign-pathology-initially-assigned-as-breast-imaging-reporting-and-data-system-category-4a-and-3
#17
Ji Young You, Hee Jung Suh, Yunju Kim, Jae Kwan Jun, Haydee Ojeda-Fournier, Kyounglan Ko
PURPOSE: This retrospective study investigated if the initially assigned category 4A or 3 in concordant benign lesions, after ultrasound (US)-guided core needle biopsy, could affect follow-up compliance. METHODS: Eight hundred thirty-eight concordant benign lesions, after core needle biopsy (674, initial category 4A group and 164, category 3 group) and follow-up US, were included in our study. If an immediate surgical excision-a surgical excision before the next follow-up-exists, those cases with pathologic reports were collected...
September 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28944115/demographics-and-incidence-of-histologically-confirmed-intracranial-tumors-a-five-year-two-center-prospective-study
#18
George S Stoyanov, Deyan L Dzhenkov, Martina Kitanova, Peter Ghenev, Anton B Tonchev
Introduction Intracranial tumors (ICTs) are a diverse group of malignancies that pose an immediate threat to patients' lives, no matter their local or metastatic origin, benign or malignant nature. These lesions have severe clinical courses and need to be diagnosed and treated as soon as possible, with pathological verification being the pivotal moment in the process of determining curative modalities. Aim The aim of this study was to compare the incidence of histologically confirmed ICTs in Eastern Bulgaria, based on their type (primary, metastatic, and non-volume occupying lesions (NVOL)), their respective subtypes, and incidence in a descriptive manner...
July 16, 2017: Curēus
https://www.readbyqxmd.com/read/28937373/radiological-tests-versus-pathological-diagnostics-complimentary-or-antagonistic-relationship-the-experience-of-a-tertiary-hospital
#19
Maria A Arafah, Hala M Kfoury
INTRODUCTION: Early detection of breast cancer plays a pivotal role in the outcome of the disease. Diagnostic modalities encompass radiological and pathological findings. The aim of this study is to evaluate the correlation between the results of these two modalities in a tertiary hospital. MATERIALS AND METHODS: From a total of 180 patients, 203 ultrasound-guided breast core needle biopsies (US-CNBs) were included in this study over a period of a year (May 2015 - May 2016)...
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28929806/clustered-microcysts-on-breast-ultrasound-what-is-an-appropriate-management-recommendation
#20
Heather I Greenwood, Amie Y Lee, Iryna V Lobach, Bianca M Carpentier, Rita I Freimanis, Loretta M Strachowski
OBJECTIVE: The objective of our study was to determine outcomes of lesions identified as clustered microcysts on breast ultrasound to augment the existing literature and help guide appropriate management recommendations. MATERIALS AND METHODS: We retrospectively identified cases at our institution, from January 2003 through December 2013, of all lesions classified as clustered microcysts at breast ultrasound. Breast ultrasound examinations were performed by the interpreting physician...
September 20, 2017: AJR. American Journal of Roentgenology
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