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PAD AND nitric oxide

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https://www.readbyqxmd.com/read/28821752/hybrid-nitric-oxide-donor-and-its-carrier-for-the-treatment-of-peripheral-arterial-diseases
#1
Duong Q Le, Aneetta E Kuriakose, Dat X Nguyen, Kytai T Nguyen, Suchismita Acharya
Nitric oxide (NO) has been known to promote physiological angiogenesis to treat peripheral arterial diseases (PAD) by increasing the vascular endothelial growth factor (VEGF) level in endothelial cells (ECs) and preventing platelet adherence and leukocyte chemotaxis. However, the ongoing ischemic event during peripheral ischemia produces superoxide and diminishes the NO bioavailability by forming toxic peroxynitrite anion. Here we disclose an efficacious hybrid molecule 4-(5-Amino-1,2,3-oxadiazol-3-yl)-2,2,6,6-tetramethyl-1-piperidinol (SA-2) containing both antioxidant and NO donor functionalities that provide a therapeutic level of NO necessary to promote angiogenesis and to protect ECs against hydrogen peroxide-induced oxidative stress...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28700908/endothelial-glycocalyx-mediated-nitric-oxide-production-in-response-to-selective-afm-pulling
#2
Anne Marie W Bartosch, Rick Mathews, John M Tarbell
Nitric oxide (NO) is a regulatory molecule in the vascular system and its inhibition due to endothelial injury contributes to cardiovascular disease. The glycocalyx is a thin layer of glycolipids, glycoproteins, and proteoglycans on the surface of mammalian epithelial cells. Extracellular forces are transmitted through the glycocalyx to initiate intracellular signaling pathways. In endothelial cells (ECs), previous studies have shown the glycocalyx to be a significant mediator of NO production; degradation of the endothelial glycocalyx layer (EGL) drastically reduces EC production of NO in response to fluid shear stress...
July 11, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28688873/extracorporeal-shockwave-therapy-for-peripheral-arterial-disease-a-review-of-the-potential-mechanisms-of-action
#3
REVIEW
Ali Raza, Amy Harwood, Joshua Totty, George Smith, Ian Chetter
BACKGROUND: Lower limb peripheral arterial disease (PAD) affects 20% of population over 65 years. Extracorporeal shockwave therapy (ESWT) has recently emerged as a novel, safe, and effective treatment option. This review aims to assess the mechanism of action by which ESWT improves symptoms in patients with PAD. METHODS: MEDLINE and EMBASE databases were searched in line with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Any article investigating the mechanism of action of ESWT in PAD was considered for inclusion...
July 6, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28688385/circular-dichroism-in-photoelectron-images-from-aligned-nitric-oxide-molecules
#4
Ananya Sen, S T Pratt, K L Reid
We have used velocity map photoelectron imaging to study circular dichroism of the photoelectron angular distributions (PADs) of nitric oxide following two-color resonance-enhanced two-photon ionization via selected rotational levels of the A (2)Σ(+), v(')=0 state. By using a circularly polarized pump beam and a counter-propagating, circularly polarized probe beam, cylindrical symmetry is preserved in the ionization process, and the images can be reconstructed using standard algorithms. The velocity map imaging set up enables individual ion rotational states to be resolved with excellent collection efficiency, rendering the measurements considerably simpler to perform than previous measurements conducted with a conventional photoelectron spectrometer...
July 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28680087/electronegative-low-density-lipoprotein-increases-the-risk-of-ischemic-lower-extremity-peripheral-artery-disease-in-uremia-patients-on-maintenance-hemodialysis
#5
Chiz-Tzung Chang, Ming-Yi Shen, An-Sean Lee, Chun-Cheng Wang, Wei-Yu Chen, Chia-Ming Chang, Kuan-Cheng Chang, Nicole Stancel, Chu-Huang Chen
Electronegative low-density lipoprotein (LDL) has been shown to increase coronary artery disease risk in hemodialysis patients, but its effect on the risk of peripheral artery disease (PAD) remains unclear. We separated plasma LDL from 90 uremia patients undergoing hemodialysis into 5 subfractions (L1-L5) according to charge by using fast-protein liquid chromatography with an anion-exchange column and examined the distribution of L5-the most electronegative LDL subfraction-in total LDL (i.e. L5%). During a 5-year period, we followed up with these patients until the occurrence of ischemic lower-extremity PAD...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28437655/peripheral-artery-disease-redox-signaling-oxidative-stress-basic-and-clinical-aspects
#6
REVIEW
Sebastian Steven, Andreas Daiber, Jörn F Dopheide, Thomas Münzel, Christine Espinola-Klein
Reactive oxygen and nitrogen species (ROS and RNS, e.g. H2O2, nitric oxide) confer redox regulation of essential cellular signaling pathways such as cell differentiation, proliferation, migration and apoptosis. At higher concentrations, ROS and RNS lead to oxidative stress and oxidative damage of biomolecules (e.g. via formation of peroxynitrite, fenton chemistry). Peripheral artery disease (PAD) is characterized by severe ischemic conditions in the periphery leading to intermittent claudication and critical limb ischemia (end stage)...
August 2017: Redox Biology
https://www.readbyqxmd.com/read/27983540/plasma-nitric-oxide-level-is-correlated-with-microvascular-functions-in-the-peripheral-arterial-disease
#7
Muzaffer Akkoca, Suzan Emel Usanmaz, Cuneyt Koksoy, Ugur Bengisun, Emine Demirel-Yilmaz
At present there is no widely accepted biomarker for monitoring of vascular functions. The purpose of this prospective study was to investigate the association of some blood biomarkers with vascular reactivity in patients with peripheral arterial diseases (PAD). A prospective evaluation was made of 3 groups comprising a control group of healthy individuals, and patients with PAD caused by either atherosclerosis or Buerger's disease. Microvascular perfusion was examined using laser Doppler imaging of cutaneous erythrocyte flux after iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP)...
2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27960614/long-term-individual-shear-rate-therapy-counterpulsation-enhances-plasma-nitrite-release-in-patients-with-pad
#8
RANDOMIZED CONTROLLED TRIAL
Michèle Brix, Eva-Elina Buschmann, Andreas Zietzer, Jonnel Anthony Jaurigue, Lulu Li, Constantin Jungk, Ivo Buschmann, Doreen Janke, Philipp Hillmeister
BACKGROUND: Individual shear rate therapy (ISRT) has been designed as a novel non-invasive treatment option for peripheral artery disease (PAD) patients and has been shown to improve endothelial function and walking distance. The aim of this study was to elucidate the impact of ISRT on the level of nitric oxide in patient blood plasma and the expression of related molecular markers in peripheral blood mononuclear cells (PBMCs). Molecular diagnostic tests were performed for two ISRT trials...
January 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/27876596/characterization-and-immunomodulatory-effects-of-glucans-from-pleurotus-albidus-a-promising-species-of-mushroom-for-farming-and-biomass-production
#9
Victor Costa Castro-Alves, Daniel Gomes, Nelson Menolli, Maurício Luís Sforça, João Roberto Oliveira do Nascimento
Polysaccharides from a number of mushroom species are recognized as functional food ingredients with potential health benefits, including immunomodulatory effects. In this study, polysaccharides extracted from the basidiome with cold water (BaCW), hot water (BaHW), and hot alkali (BaHA) solution, and exo- (MyEX) and endopolysaccharides (MyEN) from the submerged culture of Pleurotus albidus, a promising species for farming and biomass production, were analyzed for their chemical composition and structure and immunomodulatory effects on macrophages...
February 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27868196/differential-regulation-of-blood-flow-induced-neovascularization-and-mural-cell-recruitment-by-vascular-endothelial-growth-factor-and-angiopoietin-signalling
#10
Oliver A Stone, James G Carter, P Charles Lin, Ewa Paleolog, Maria J C Machado, David O Bates
KEY POINTS: Combining nitric oxide (NO)-mediated increased blood flow with angiopoietin-1-Tie2 receptor signalling induces arteriolargenesis - the formation of arterioles from capillaries - in a model of physiological angiogenesis. This NO-Tie-mediated arteriolargenesis requires endogenous vascular endothelial growth factor (VEGF) signalling. Inhibition of VEGF signalling increases pericyte coverage in microvessels. Together these findings indicate that generation of functional neovasculature requires close titration of NO-Tie2 signalling and localized VEGF induction, suggesting that the use of exogenous VEGF expression as a therapeutic for neovascularization may not be successful...
March 1, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/27616684/infrapatellar-fat-pad-aggravates-degeneration-of-acute-traumatized-cartilage-a-possible-role-for-interleukin-6
#11
J He, Y Jiang, P G Alexander, V Ulici, Y Zhu, S Wu, R S Tuan
OBJECTIVES: The infrapatellar fat pad (IPFP), which is located underneath the patella, close to cartilage surfaces, functions in distributing mechanical load and has been shown to produce cytokines. This study aims to assess the involvement of the IPFP in the progression of post-traumatic osteoarthritis (OA) through investigating the crosstalk between the IPFP and injured cartilage in vitro. METHODS: A single blunt impact (36 MPa) on healthy bovine articular cartilage explants was used to generate traumatized cartilage...
January 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27396508/exposure-to-high-fat-diet-since-post-weaning-induces-cardiometabolic-damage-in-adult-rats
#12
P Fiorino, A L V Américo, C R Muller, F S Evangelista, F Santos, A P O Leite, V Farah
AIMS: This study sought to investigate the metabolic, hemodynamic and autonomic responses in adult rats exposed to high-fat diet since post-weaning. MAIN METHODS: Young male Wistar rats were assigned into groups fed with standard normal diet (3% lipids; ND, n=8) or high-fat diet (30% lipids; HD, n=8) during 8weeks. Body composition, food intake, serum triglycerides, total cholesterol, insulin, leptin and adiponectin concentrations were determined. Hemodynamic and autonomic evaluations were performed...
September 1, 2016: Life Sciences
https://www.readbyqxmd.com/read/26942010/a-comparison-of-measures-of-endothelial-function-in-patients-with-peripheral-arterial-disease-and-age-and-gender-matched-controls
#13
Richard B Allan, Simon V Vun, J Ian Spark
This study compared flow-mediated dilatation (FMD), peripheral artery tonometry (PAT), and serum nitric oxide (NO) measures of endothelial function in patients with peripheral artery disease (PAD) against age/gender matched controls. 25 patients (mean age: 72.4 years, M : F 18 : 7) with established PAD and an age/gender matched group of 25 healthy controls (mean age: 72.4 years, M : F 18 : 7) were studied. Endothelial function was measured using the % FMD, reactive hyperemia index (RHI) using PAT and serum NO (μmol)...
2016: International Journal of Vascular Medicine
https://www.readbyqxmd.com/read/26912972/nanotamoxifen-delivery-system-toxicity-assessment-after-oral-administration-and-biodistribution-study-after-intravenous-delivery-of-radiolabeled-nanotamoxifen
#14
Jaya Shukla, Amit Kumar Dinda, Abhay Krishna Srivastava, Kamna Srivastava, Bhagwant Rai Mittal, Guru Pad Bandopadhyaya
Tamoxifen is the most prescribed anticancer oral drug for increasing overall survival and decreasing recurrence and the risk of contralateral disease. However, some side effects, such as endometrial and liver tumors, thromboembolic disorders, and drug resistance, are associated with long-term tamoxifen treatment. We assessed the hematologic and organ toxicity after oral administration of three different doses of nanotamoxifen formulations. We also performed biodistribution studies of Technetium-99m ((99m)Tc)-nanotamoxifen after intravenous administration...
January 2016: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/26411939/-recent-knowledge-of-smoking-and-peripheral-arterial-disease-in-lower-extremities
#15
REVIEW
Yoko Sotoda, Shigeki Hirooka, Hiroyuki Orita, Ichiro Wakabayashi
Peripheral arterial disease (PAD) is an atherosclerotic obstructive disease of the arteries in lower extremities. Patients with PAD show high rates of mortality from coronary artery disease (CAD) and stroke. Smoking as well as diabetes is an important risk factor for PAD. A lesion of PAD in the lower extremities tends to be more proximal in smokers than in nonsmokers and to be more distal in patients with diabetes than in nondiabetics. By a systematic review, the odds ratio for PAD of smokers vs nonsmokers has been reported to be in the range of 1...
2015: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
https://www.readbyqxmd.com/read/26156267/new-therapeutic-effects-of-cilostazol-in-patients-with-ischemic-disorders
#16
REVIEW
Federico Biscetti, Gianfranco Ferraccioli, Andrea Flex
Cilostazol (CIL) is effective for the treatment of patients with peripheral arterial disease (PAD). CIL is an orally administered drug with multiple effects, including anti-platelets aggregation, favorable functions on plasmatic lipids and vasodilator ones, but how these effects might be related to improvement in patients walking affected by PAD is not fully understood. The latest data demonstrate that nitric oxide (NO) is induced by CIL through endothelial nitric oxide synthase (eNOS) activation via a cyclic-AMP (cAMP)/ protein kinase A (PKA)- and PI3K/Akt- dependent mechanism...
2015: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/26134126/bilirubin-exerts-pro-angiogenic-property-through-akt-enos-dependent-pathway
#17
Yasumasa Ikeda, Hirofumi Hamano, Akiho Satoh, Yuya Horinouchi, Yuki Izawa-Ishizawa, Yoshitaka Kihira, Keisuke Ishizawa, Ken-Ichi Aihara, Koichiro Tsuchiya, Toshiaki Tamaki
Low serum bilirubin levels are associated with the risk of cardiovascular diseases including peripheral artery disease. Bilirubin is known to exert its property such as antioxidant effect or the enhancement of flow-mediated vasodilation, however, bilirubin action on angiogenesis remains unclear. To investigate the molecular mechanism of bilirubin on angiogenic effect, we first employed C57BL/6J mice with unilateral hindlimb ischemia surgery and divided the mice into two groups (vehicle-treated group and bilirubin-treated group)...
November 2015: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/26123989/effects-of-chronic-oral-l-arginine-administration-on-the-l-arginine-no-pathway-in-patients-with-peripheral-arterial-occlusive-disease-or-coronary-artery-disease-l-arginine-prevents-renal-loss-of-nitrite-the-major-no-reservoir
#18
Jessica Y Schneider, Sabine Rothmann, Frank Schröder, Jennifer Langen, Thomas Lücke, François Mariotti, Jean François Huneau, Jürgen C Frölich, Dimitrios Tsikas
Despite saturation of nitric oxide (NO) synthase (NOS) by its substrate L-arginine (Arg), oral and intravenous supplementation of Arg may enhance NO synthesis, a phenomenon known as "The L-arginine paradox". Yet, Arg is not only a source of NO, but is also a source for guanidine-methylated (N (G)) arginine derivatives which are all inhibitors of NOS activity. Therefore, Arg supplementation may not always result in enhanced NO synthesis. Concomitant synthesis of N (G)-monomethyl arginine (MMA), N (G),N (G)-dimethylarginine (asymmetric dimethylarginine, ADMA) and N (G),N (G´)-dimethylarginine (symmetric dimethylarginine, SDMA) from supplemented Arg may outweigh and even outbalance the positive effects of Arg on NO...
September 2015: Amino Acids
https://www.readbyqxmd.com/read/26031828/biosynthesis-of-homoarginine-harg-and-asymmetric-dimethylarginine-adma-from-acutely-and-chronically-administered-free-l-arginine-in-humans
#19
RANDOMIZED CONTROLLED TRIAL
Arslan Arinc Kayacelebi, Jennifer Langen, Katharina Weigt-Usinger, Kristine Chobanyan-Jürgens, François Mariotti, Jessica Y Schneider, Sabine Rothmann, Jürgen C Frölich, Dorothee Atzler, Chi-Un Choe, Edzard Schwedhelm, Jean François Huneau, Thomas Lücke, Dimitrios Tsikas
Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis, whereas L-arginine (Arg) and L-homoarginine (hArg) serve as substrates for NO synthesis. ADMA and other methylated arginines are generally believed to exclusively derive from guanidine (N (G))-methylated arginine residues in proteins by protein arginine methyltransferases (PRMTs) that use S-adenosylmethionine (SAM) as the methyl donor. L-Lysine is known for decades as a precursor for hArg, but only recent studies indicate that arginine:glycine amidinotransferase (AGAT) is responsible for the synthesis of hArg...
September 2015: Amino Acids
https://www.readbyqxmd.com/read/25981561/plasma-levels-of-acylated-ghrelin-in-children-with-pulmonary-hypertension-associated-with-congenital-heart-disease
#20
Gang Li, Jiyi Xia, Peng Jia, Jian Zhao, Yuqin Sun, Changxue Wu, Bin Liu
This study aims to estimate plasma levels of acylated ghrelin in children with pulmonary hypertension (PH) associated with congenital heart disease (CHD) and to correlate the levels of acylated ghrelin with endothelin-1 (ET-1), nitric oxide (NO), and clinical hemodynamic parameters. We investigated the plasma concentration of acylated ghrelin, ET-1, NO, and the hemodynamic parameters in 20 children with CHD, 20 children with PH-CHD, and 20 normal children. Plasma-acylated ghrelin and NO levels were significantly higher in CHD group than in control subjects (P < 0...
October 2015: Pediatric Cardiology
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