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https://www.readbyqxmd.com/read/28530795/modelling-living-cells-response-to-surface-tension-and-chemical-patterns
#1
Marco Macis, Francesca Lugli, Francesco Zerbetto
Mechanobiology is an important epigenetic factor. It influences cell functioning and bears on gene induction, protein synthesis, cell growth and differentiation. In the presence of patterned chemical cues, living cells can take shapes that are far from that of a drop of fluid. These shapes are characterized by inward curvatures that are pinned at the points of location of the cues. The mechano-chemical interactions that orchestrate cell behavior is simulated and controlled by modeling the cells as made by parcels of fluid...
May 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28526527/cellular-scale-model-of-growth-plate-an-in-silico-model-of-chondrocyte-hypertrophy
#2
H A Castro-Abril, J M Guevara, M A Moncayo, S J Shefelbine, L A Barrera, D A Garzón-Alvarado
The growth plate is the responsible for longitudinal bone growth. It is a cartilaginous structure formed by chondrocytes that are continuously undergoing a differentiation process that starts with a highly proliferative state, followed by cellular hypertrophy, and finally tissue ossification. Within the growth plate chondrocytes display a characteristic columnar organization that potentiates longitudinal growth. Both chondrocyte organization and hypertrophy are highly regulated processes influenced by biochemical and mechanical stimuli...
May 16, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28522885/dynamically-tunable-cell-culture-platforms-for-tissue-engineering-and-mechanobiology
#3
Koichiro Uto, Jonathan H Tsui, Cole A DeForest, Deok-Ho Kim
Human tissues are sophisticated ensembles of many distinct cell types embedded in the complex, but well-defined, structures of the extracellular matrix (ECM). Dynamic biochemical, physicochemical, and mechano-structural changes in the ECM define and regulate tissue-specific cell behaviors. To recapitulate this complex environment in vitro, dynamic polymer-based biomaterials have emerged as powerful tools to probe and direct active changes in cell function. The rapid evolution of polymerization chemistries, structural modulation, and processing technologies, as well as the incorporation of stimuli-responsiveness, now permit synthetic microenvironments to capture much of the dynamic complexity of native tissue...
February 2017: Progress in Polymer Science
https://www.readbyqxmd.com/read/28513702/stretchable-impedance-sensor-for-mammalian-cell-proliferation-measurements
#4
Xudong Zhang, William Wang, Fang Li, Ioana Voiculescu
This paper presents the fabrication and testing of a novel stretchable electric cell-substrate impedance sensing (ECIS) lab on a chip device. This is the first time that ECIS electrodes were fabricated on a stretchable polydimethylsiloxane (PDMS) substrate and ECIS measurements were performed on mammalian cells exposed to cyclic strain. The stretchable ECIS biosensors simulate in vitro the dynamic environment of organisms, such as pulsation, bending and stretching, which enables investigations on cell behavior that undergoes mechanical stimuli in biological tissue...
May 17, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28502789/supported-lipid-bilayer-platforms-to-probe-cell-mechanobiology
#5
REVIEW
Roxanne Glazier, Khalid Salaita
Mammalian and bacterial cells sense and exert mechanical forces through the process of mechanotransduction, which interconverts biochemical and physical signals. This is especially important in contact-dependent signaling, where ligand-receptor binding occurs at cell-cell or cell-ECM junctions. By virtue of occurring within these specialized junctions, receptors engaged in contact-dependent signaling undergo oligomerization and coupling with the cytoskeleton as part of their signaling mechanisms. While our ability to measure and map biochemical signaling within cell junctions has advanced over the past decades, physical cues remain difficult to map in space and time...
May 11, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28494959/mechanosensitive-conformation-of-vinculin-regulates-its-binding-to-mapk1
#6
Kiavash Garakani, Hengameh Shams, Mohammad R K Mofrad
Extracellular matrix stiffness sensing by living cells is known to play a major role in a variety of cell mechanobiological processes, such as migration and differentiation. Various membrane and cytoplasmic proteins are involved in transmitting and transducing environmental signals to biochemical cascades. Protein kinases play a key role in regulating the activity of focal adhesion proteins. Recently, an interaction between mitogen-activated protein kinase (MAPK1) and vinculin was experimentally shown to mediate this process...
May 9, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28488754/virtual-endovascular-treatment-of-intracranial-aneurysms-models-and-uncertainty
#7
REVIEW
Ali Sarrami-Foroushani, Toni Lassila, Alejandro F Frangi
Virtual endovascular treatment models (VETMs) have been developed with the view to aid interventional neuroradiologists and neurosurgeons to pre-operatively analyze the comparative efficacy and safety of endovascular treatments for intracranial aneurysms. Based on the current state of VETMs in aneurysm rupture risk stratification and in patient-specific prediction of treatment outcomes, we argue there is a need to go beyond personalized biomechanical flow modeling assuming deterministic parameters and error-free measurements...
May 10, 2017: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/28483699/mechanical-phenotyping-of-cells-and-extracellular-matrix-as-grade-and-stage-markers-of-lung-tumor-tissues
#8
Valeria Panzetta, Ida Musella, Ida Rapa, Marco Volante, Paolo A Netti, Sabato Fusco
The mechanical cross-talk between cells and the extra-cellular matrix (ECM) regulates the properties, functions and healthiness of the tissues. When this is disturbed it changes the mechanical state of the tissue components, singularly or together, and cancer, along with other diseases, may start and progress. However, the bi-univocal mechanical interplay between cells and the ECM is still not properly understood. In this study we show how a microrheology technique gives us the opportunity to evaluate the mechanics of cells and the ECM at the same time...
May 5, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28478795/cell-biology-biophysics-and-mechanobiology-from-the-basics-to-clinics
#9
Y Zeng
Cell biology, biomechanics and biophysics are the key subjects that guide our understanding in diverse areas of tissue growth, development, remodeling and homeostasis. Novel discoveries such as molecular mechanism, and mechanobiological mechanism in cell biology, biomechanics and biophysics play essential roles in our understanding of the pathogenesis of various human diseases, as well as in designing the treatment of these diseases. In addition, studies in these areas will also facilitate early diagnostics of human diseases, such as cardiovascular diseases and cancer...
April 29, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28476202/periodontal-ligament-entheses-and-their-adaptive-role-in-the-context-of-dentoalveolar-joint-function
#10
REVIEW
Jeremy D Lin, Andrew T Jang, Michael P Kurylo, Jonathan Hurng, Feifei Yang, Lynn Yang, Arvin Pal, Ling Chen, Sunita P Ho
OBJECTIVE: The dynamic bone-periodontal ligament (PDL)-tooth fibrous joint consists of two adaptive functionally graded interfaces (FGI), the PDL-bone and PDL-cementum that respond to mechanical strain transmitted during mastication. In general, from a materials and mechanics perspective, FGI prevent catastrophic failure during prolonged cyclic loading. This review is a discourse of results gathered from literature to illustrate the dynamic adaptive nature of the fibrous joint in response to physiologic and pathologic simulated functions, and experimental tooth movement...
May 2, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28453955/acoustic-tweezing-cytometry-enhances-osteogenesis-of-human-mesenchymal-stem-cells-through-cytoskeletal-contractility-and-yap-activation
#11
Xufeng Xue, Xiaowei Hong, Zida Li, Cheri X Deng, Jianping Fu
Human mesenchymal stem cells (hMSCs) have great potential for cell-based therapies for treating degenerative bone diseases. It is known that mechanical cues in the cell microenvironment play an important role in regulating osteogenic (bone) differentiation of hMSCs. However, mechanoregulation of lineage commitment of hMSCs in conventional two-dimensional (2D) monocultures or bioengineered three-dimensional (3D) tissue constructs remains suboptimal due to complex biomaterial design criteria for hMSC culture...
April 22, 2017: Biomaterials
https://www.readbyqxmd.com/read/28448920/the-effect-of-equiaxial-stretching-on-the-osteogenic-differentiation-and-mechanical-properties-of-human-adipose-stem-cells
#12
Sanni Virjula, Feihu Zhao, Joni Leivo, Sari Vanhatupa, Joose Kreutzer, Ted J Vaughan, Anna-Maija Honkala, Marlitt Viehrig, Conleth A Mullen, Pasi Kallio, Laoise M McNamara, Susanna Miettinen
Although mechanical cues are known to affect stem cell fate and mechanobiology, the significance of such stimuli on the osteogenic differentiation of human adipose stem cells (hASCs) remains unclear. In this study, we investigated the effect of long-term mechanical stimulation on the attachment, osteogenic differentiation and mechanical properties of hASCs. Tailor-made, pneumatic cell stretching devices were used to expose hASCs to cyclic equiaxial stretching in osteogenic medium. Cell attachment and focal adhesions were visualised using immunocytochemical vinculin staining on days 3 and 6, and the proliferation and alkaline phosphatase activity, as a sign of early osteogenic differentiation, were analysed on days 0, 6 and 10...
April 13, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28429161/on-the-in-vivo-function-of-the-mitral-heart-valve-leaflet-insights-into-tissue-interstitial-cell-biomechanical-coupling
#13
Chung-Hao Lee, Will Zhang, Kristen Feaver, Robert C Gorman, Joseph H Gorman, Michael S Sacks
There continues to be a critical need for developing data-informed computational modeling techniques that enable systematic evaluations of mitral valve (MV) function. This is important for a better understanding of MV organ-level biomechanical performance, in vivo functional tissue stresses, and the biosynthetic responses of MV interstitial cells (MVICs) in the normal, pathophysiological, and surgically repaired states. In the present study, we utilized extant ovine MV population-averaged 3D fiducial marker data to quantify the MV anterior leaflet (MVAL) deformations in various kinematic states...
April 20, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28427319/mechanobiological-modelling-of-tendons-review-and-future-opportunities
#14
Mark S Thompson, M Nazri Bajuri, Hanifeh Khayyeri, Hanna Isaksson
Tendons are adapted to carry large, repeated loads and are clinically important for the maintenance of musculoskeletal health in an increasing, actively ageing population, as well as in elite athletes. Tendons are known to adapt to mechanical loading. Also, their healing and disease processes are highly sensitive to mechanical load. Computational modelling approaches developed to capture this mechanobiological adaptation in tendons and other tissues have successfully addressed many important scientific and clinical issues...
May 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28406209/mechanobiology-a-measure-of-molecular-muscle
#15
Michael Eisenstein
No abstract text is available yet for this article.
April 12, 2017: Nature
https://www.readbyqxmd.com/read/28403507/endothelial-dysfunction-and-mechanobiology-in-pathological-cutaneous-scarring-lessons-learned-from-soft-tissue-fibrosis
#16
REVIEW
C Huang, L Liu, Z You, Y Zhao, J Dong, Y Du, R Ogawa
Hypertrophic scars/keloids are pathogenic scars that are characterized by collagen and fibroblast accumulation. The endothelia in the lesions are mechanosensitive and participate actively in the pathogenesis of these scars. The present review summarizes how endothelium responds to mechanical stimuli such as shear, stretch, and hydrostatic pressure. It also shows that in heart, liver, kidney, and lung fibrosis, endothelial dysfunctions (EDs) associate with changes in vascular tone, endothelial permeability, coagulation, and vasomodulation that result in inflammation, hypertension, and coagulation...
April 12, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28391171/a-two-scale-modeling-and-computational-framework-for-vibration-induced-raynaud-syndrome
#17
Yue Hua, Pierre Lemerle, Jean-François Ganghoffer
Hand-Arm Vibration syndrome (HAVS), usually caused by long-term use of hand-held power tools, can in certain manifestations alter the peripheral blood circulation in the hand-arm region. HAVS typically occurs after exposure to cold, causing an abnormally strong vasoconstriction of blood vessels. A pathoanatomical mechanism suggests that a reduction of the lumen of the blood vessels in VWF (Vibration White Finger) subjects, due to either hypertrophy or thickening of the vessel wall, may be at the origin of the disease...
March 28, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28377988/bone-fracture-healing-in-mechanobiological-modeling-a-review-of-principles-and-methods
#18
REVIEW
Mohammad S Ghiasi, Jason Chen, Ashkan Vaziri, Edward K Rodriguez, Ara Nazarian
Bone fracture is a very common body injury. The healing process is physiologically complex, involving both biological and mechanical aspects. Following a fracture, cell migration, cell/tissue differentiation, tissue synthesis, and cytokine and growth factor release occur, regulated by the mechanical environment. Over the past decade, bone healing simulation and modeling has been employed to understand its details and mechanisms, to investigate specific clinical questions, and to design healing strategies. The goal of this effort is to review the history and the most recent work in bone healing simulations with an emphasis on both biological and mechanical properties...
June 2017: Bone Reports
https://www.readbyqxmd.com/read/28372277/mechanobiology-of-mesenchymal-stem-cells-which-interest-for-cell-based-treatment
#19
Céline Huselstein, R Rahouadj, N de Isla, D Bensoussan, J F Stoltz, Y P Li
Thanks to their immune properties, the mesenchymal stem cells (MSC) are a promising source for cell therapy. Current clinical trials show that MSC administrated to patients can treat different diseases (graft-versus-host disease (GVHD), liver cirrhosis, systemic lupus, erythematosus, rheumatoid arthritis, type I diabetes…). In this case, the most common mode of cell administration is the intravenous injection, and the hemodynamic environment of cells induced by blood circulation could interfere on their behavior during the migration and homing towards the injured site...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28372275/examples-of-multiscale-and-multiphysics-numerical-modeling-of-biological-tissues
#20
Daniel George, Camille Spingarn, Caroline Dissaux, Mathieu Nierenberger, Ranya Abdel Rahman, Yves Rémond
Predictive theoretical-numerical modeling of the behavior and evolution of biological tissue is a difficult task since many of the required knowledge tools (experimental, theoretical and numerical) are still not well understood. We present here some methodologies and results specific to multiscale and multiphysics numerical modeling of biological tissues applied to the predictive behavior of cortical veins depending on their local constituents' microstructure and for bone remodeling and reconstruction as a function of the local mechanobiology...
2017: Bio-medical Materials and Engineering
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