keyword
MENU ▼
Read by QxMD icon Read
search

mechanobiology

keyword
https://www.readbyqxmd.com/read/28823079/mechanobiological-model-of-arterial-growth-and-remodeling
#1
Maziyar Keshavarzian, Clark A Meyer, Heather N Hayenga
A coupled agent-based model (ABM) and finite element analysis (FEA) computational framework is developed to study the interplay of bio-chemo-mechanical factors in blood vessels and their role in maintaining homeostasis. The agent-based model implements the power of REPAST Simphony libraries and adapts its environment for biological simulations. Coupling a continuum-level model (FEA) to a cellular-level model (ABM) has enabled this computational framework to capture the response of blood vessels to increased or decreased levels of growth factors, proteases and other signaling molecules (on the micro scale) as well as altered blood pressure...
August 19, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28817244/key-developments-that-impacted-the-field-of-mechanobiology-and-mechanotransduction
#2
Michelle Wall, David Butler, Alicia El Haj, Josephine C Bodle, Elizabeth G Loboa, Albert J Banes
Advances in mechanobiology have evolved through insights from multiple disciplines including structural engineering, biomechanics, vascular biology, and orthopaedics. In this paper, we reviewed the impact of key reports related to the study of applied loads on tissues and cells and the resulting signal transduction pathways. We addressed how technology has helped advance the burgeoning field of mechanobiology (over 33,600 publications from 1970-2016). We analyzed the impact of critical ideas and then determined how these concepts influenced the mechanobiology field by looking at the citation frequency of these reports as well as tracking how the overall number of citations within the field changed over time...
August 17, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28811171/molecular-sensors-of-blood-flow-in-endothelial-cells
#3
REVIEW
Sara Baratchi, Khashayar Khoshmanesh, Owen L Woodman, Simon Potocnik, Karlheinz Peter, Peter McIntyre
Mechanical stress from blood flow has a significant effect on endothelial physiology, with a key role in initiating vasoregulatory signals. Disturbances in blood flow, such as in regions of disease-associated stenosis, arterial branch points, and sharp turns, can induce proatherogenic phenotypes in endothelial cells. The disruption of vascular homeostasis as a result of endothelial dysfunction may contribute to early and late stages of atherosclerosis, the underlying cause of coronary artery disease. In-depth knowledge of the mechanobiology of endothelial cells is essential to identifying mechanosensory complexes involved in the pathogenesis of atherosclerosis...
August 12, 2017: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/28807504/bone-up-craniomandibular-development-and-hard-tissue-biomineralization-in-neonate-mice
#4
Khari D Thompson, Holly E Weiss-Bilka, Elizabeth B McGough, Matthew J Ravosa
The presence of regional variation in the osteogenic abilities of cranial bones underscores the fact that the mechanobiology of the mammalian skull is more complex than previously recognized. However, the relationship between patterns of cranial bone formation and biomineralization remains incompletely understood. In four strains of mice, micro-computed tomography was used to measure tissue mineral density during perinatal development in three skull regions (calvarium, basicranium, mandible) noted for variation in loading environment, embryological origin, and ossification mode...
January 29, 2017: Zoology: Analysis of Complex Systems, ZACS
https://www.readbyqxmd.com/read/28755470/the-role-of-mechanobiology-in-progression-of-rotator-cuff-muscle-atrophy-and-degeneration
#5
Michael C Gibbons, Anshuman Singh, Adam J Engler, Samuel R Ward
Rotator cuff (RC) muscles undergo several detrimental changes following mechanical unloading resulting from RC tendon tear. In this review, we highlight the pathological causes and consequences of mechanical alterations at the whole muscle, muscle fiber, and muscle resident cell level as they relate to RC disease progression. In brief, the altered mechanical loads associated with RC tear lead to architectural, structural, and compositional changes at the whole-muscle and muscle fiber level. At the cellular level, these changes equate to direct disruption of mechanobiological signaling, which is exacerbated by mechanically regulated biophysical and biochemical changes to the cellular and extra-cellular environment (also known as the stem cell "niche")...
July 29, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28754649/stretching-single-fibrin-fibers-hampers-their-lysis
#6
Wei Li, Tomas Lucioni, Rongzhong Li, Keith Bonin, Samuel S Cho, Martin Guthold
Blood clots, whose main structural component is a mesh of microscopic fibrin fibers, experience mechanical strain from blood flow, clot retraction and interactions with platelets and other cells. We developed a transparent, striated and highly stretchable substrate made from fugitive glue (a styrenic block copolymer) to investigate how mechanical strain affects lysis of single, suspended fibrin fibers. In this suspended fiber assay, lysis manifested itself by fiber elongation, thickening (disassembly), fraying and collapse...
July 25, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28754443/nanoscale-mechanobiology-of-cell-adhesions
#7
REVIEW
Shumin Xia, Pakorn Kanchanawong
Proper physiological functions of cells and tissues depend upon their abilities to sense, transduce, integrate, and generate mechanical and biochemical signals. Although such mechanobiological phenomena are widely observed, the molecular mechanisms driving these outcomes are still not fully understood. Cell adhesions formed by integrins and cadherins receptors are key structures that process diverse sources of signals to elicit complex mechanobiological responses. Since the nanoscale is the length scale at which molecules interact to relay force and information, the understanding of cell adhesions at the nanoscale level is important for grasping the inner logics of cellular decision making...
July 25, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28747783/engineering-the-geometrical-shape-of-mesenchymal-stromal-cells-through-defined-cyclic-stretch-regimens
#8
Brandan Walters, Tatiana Uynuk-Ool, Miriam Rothdiener, Julian Palm, Melanie L Hart, Jan P Stegemann, Bernd Rolauffs
Stem cells have been predicted to improve disease outcomes and patient lives. Steering stem cell fate - through controlling cell shape - may substantially accelerate progress towards this goal. As mesenchymal stromal cells (MSCs) are continuously exposed in vivo to a dynamically changing biomechanical environment, we hypothesized that exogenous forces can be applied for engineering a variety of significantly different MSC shapes. We applied specific cyclic stretch regimens to human MSCs and quantitatively measured the resulting cell shape, alignment, and expression of smooth muscle (SMC) differentiation markers, as those have been associated with elongated morphology...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747514/mechanoresponsive-stem-cells-to-target-cancer-metastases-through-biophysical-cues
#9
Linan Liu, Shirley X Zhang, Wenbin Liao, Henry P Farhoodi, Chi W Wong, Claire C Chen, Aude I Ségaliny, Jenu V Chacko, Lily P Nguyen, Mengrou Lu, George Polovin, Egest J Pone, Timothy L Downing, Devon A Lawson, Michelle A Digman, Weian Zhao
Despite decades of effort, little progress has been made to improve the treatment of cancer metastases. To leverage the central role of the mechanoenvironment in cancer metastasis, we present a mechanoresponsive cell system (MRCS) to selectively identify and treat cancer metastases by targeting the specific biophysical cues in the tumor niche in vivo. Our MRCS uses mechanosensitive promoter-driven mesenchymal stem cell (MSC)-based vectors, which selectively home to and target cancer metastases in response to specific mechanical cues to deliver therapeutics to effectively kill cancer cells, as demonstrated in a metastatic breast cancer mouse model...
July 26, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28743639/bidirectional-mechanobiology-between-cells-and-their-local-extracellular-matrix-probed-by-atomic-force-microscopy
#10
REVIEW
Jordi Alcaraz, Jorge Otero, Ignasi Jorba, Daniel Navajas
There is growing recognition that the mechanical interactions between cells and their local extracellular matrix (ECM) are central regulators of tissue development, homeostasis, repair and disease progression. The unique ability of atomic force microscopy (AFM) to probe quantitatively mechanical properties and forces at the nanometer or micrometer scales in all kinds of biological samples has been instrumental in the recent advances in cell and tissue mechanics. In this review we illustrate how AFM has provided important insights on our current understanding of the mechanobiology of cells, ECM and cell-ECM bidirectional interactions, particularly in the context of soft acinar tissues like the mammary gland or pulmonary tissue...
July 22, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28735414/bone-mechanobiology-in-mice-toward-single-cell-in-vivo-mechanomics
#11
Ariane Scheuren, Esther Wehrle, Felicitas Flohr, Ralph Müller
Mechanically driven bone (re)modeling is a multiscale process mediated through complex interactions between multiple cell types and their microenvironments. However, the underlying mechanisms of how cells respond to mechanical signals are still unclear and are at the focus of the field of bone mechanobiology. Traditionally, this complex process has been addressed by reducing the system to single scales and cell types. It is only recently that more integrative approaches have been established to study bone mechanobiology across multiple scales in which mechanical load at the organ level is related to molecular responses at the cellular level...
July 22, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28705250/effect-of-manufacturing-and-experimental-conditions-on-the-mechanical-and-surface-properties-of-silicone-elastomer-scaffolds-used-in-endothelial-mechanobiological-studies
#12
Marc-Antoine Campeau, Audrey Lortie, Pierrick Tremblay, Marc-Olivier Béliveau, Dominic Dubé, Ève Langelier, Léonie Rouleau
BACKGROUND: Mechanobiological studies allow the characterization of cell response to mechanical stresses. Cells need to be supported by a material with properties similar to the physiological environment. Silicone elastomers have been used to produce various in vitro scaffolds of different geometries for endothelial cell studies given its relevant mechanical, optical and surface properties. However, obtaining defined and repeatable properties is a challenge as depending on the different manufacturing and processing steps, mechanical and surface properties may vary significantly between research groups...
July 14, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28696483/combined-bone-ingrowth-and-remodelling-around-uncemented-acetabular-component-a-multiscale-mechanobiology-based-finite-element-analysis
#13
Kaushik Mukherjee, Sanjay Gupta
Bone ingrowth and remodelling are two different evolutionary processes which might occur simultaneously. Both these processes are influenced by local mechanical stimulus. However, a combined study on bone ingrowth and remodelling has rarely been performed. This study is aimed at understanding the relationship between bone ingrowth and adaptation and their combined influence on fixation of the acetabular component. Based on 3-D macroscale FE model of implanted pelvis and microscale FE model of implant-bone interface, a multiscale framework has been developed...
July 11, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28696002/mitochondrial-dysfunction-is-an-acute-response-of-articular-chondrocytes-to-mechanical-injury
#14
Michelle L Delco, Edward D Bonnevie, Lawrence J Bonassar, Lisa A Fortier
Mitochondrial (MT) dysfunction is known to occur in chondrocytes isolated from end-stage osteoarthritis (OA) patients, but the role of MT dysfunction in the initiation and early pathogenesis of post-traumatic OA (PTOA) remains unclear. The objective of this study was to investigate chondrocyte MT function immediately following mechanical injury in cartilage, and to determine if the response to injury differed between a weight bearing region (medial femoral condyle; MFC) and a non-weight bearing region (distal patellofemoral groove; PFG) of the same joint...
July 11, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28694489/high-frequency-components-of-hemodynamic-shear-stress-profiles-are-a-major-determinant-of-shear-mediated-platelet-activation-in-therapeutic-blood-recirculating-devices
#15
Filippo Consolo, Jawaad Sheriff, Silvia Gorla, Nicolò Magri, Danny Bluestein, Federico Pappalardo, Marvin J Slepian, Gianfranco B Fiore, Alberto Redaelli
We systematically analyzed the relative contributions of frequency component elements of hemodynamic shear stress waveforms encountered in cardiovascular blood recirculating devices as to overall platelet activation over time. We demonstrated that high frequency oscillations are the major determinants for priming, triggering and yielding activated "prothrombotic behavior" for stimulated platelets, even if the imparted shear stress has low magnitude and brief exposure time. Conversely, the low frequency components of the stress signal, with limited oscillations over time, did not induce significant activation, despite being of high magnitude and/or exposure time...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28688729/cellular-mechanosensing-of-the-biophysical-microenvironment-a-review-of-mathematical-models-of-biophysical-regulation-of-cell-responses
#16
REVIEW
Bo Cheng, Min Lin, Guoyou Huang, Yuhui Li, Baohua Ji, Guy M Genin, Vikram S Deshpande, Tian Jian Lu, Feng Xu
Cells in vivo reside within complex microenvironments composed of both biochemical and biophysical cues. The dynamic feedback between cells and their microenvironments hinges upon biophysical cues that regulate critical cellular behaviors. Understanding this regulation from sensing to reaction to feedback is therefore critical, and a large effort is afoot to identify and mathematically model the fundamental mechanobiological mechanisms underlying this regulation. This review provides a critical perspective on recent progress in mathematical models for the responses of cells to the biophysical cues in their microenvironments, including dynamic strain, osmotic shock, fluid shear stress, mechanical force, matrix rigidity, porosity, and matrix shape...
June 21, 2017: Physics of Life Reviews
https://www.readbyqxmd.com/read/28684609/single-and-collective-cell-migration-the-mechanics-of-adhesions
#17
Chiara De Pascalis, Sandrine Etienne-Manneville
Chemical and physical properties of the environment control cell proliferation, differentiation, or apoptosis in the long term. However, to be able to move and migrate through a complex three-dimensional environment, cells must quickly adapt in the short term to the physical properties of their surroundings. Interactions with the extracellular matrix (ECM) occur through focal adhesions or hemidesmosomes via the engagement of integrins with fibrillar ECM proteins. Cells also interact with their neighbors, and this involves various types of intercellular adhesive structures such as tight junctions, cadherin-based adherens junctions, and desmosomes...
July 7, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28684607/forces-that-shape-fission-yeast-cells
#18
Fred Chang
One of the major challenges of modern cell biology is to understand how cells are assembled from nanoscale components into micrometer-scale entities with a specific size and shape. Here I describe how our quest to understand the morphogenesis of the fission yeast Schizosaccharomyces pombe drove us to investigate cellular mechanics. These studies build on the view that cell shape arises from the physical properties of an elastic cell wall inflated by internal turgor pressure. Consideration of cellular mechanics provides new insights into not only mechanisms responsible for cell-shape determination and growth, but also cellular processes such as cytokinesis and endocytosis...
July 7, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28682003/impact-insertion-of-osteochondral-grafts-interference-fit-and-central-graft-reduction-affect-biomechanics-and-cartilage-damage
#19
Alvin W Su, Yunchan Chen, Dustin H Wailes, Van W Wong, Shengqiang Cai, Albert C Chen, William D Bugbee, Robert L Sah
An osteochondral graft (OCG) is an effective treatment for articular cartilage and osteochondral defects. Impact of an OCG during insertion into the osteochondral recipient site (OCR) can cause chondrocyte death and matrix damage. The aim of the present study was to analyze the effects of graft-host interference fit and a modified OCG geometry on OCG insertion biomechanics and cartilage damage. The effects of interference fit (radius of OCG - radius of OCR), loose (0.00mm), moderate (0.05mm), tight (0.10mm), and of a tight fit with OCG geometry modification (central region of decreased radius) were analyzed for OCG cylinders and OCR blocks from adult bovine knee joints with an instrumented drop tower apparatus...
July 6, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28680670/finite-element-modelling-of-mechanobiological-factors-influencing-sesamoid-tissue-morphology-in-the-patellar-tendon-of-an-ostrich
#20
Kyle P Chadwick, Sandra J Shefelbine, Andrew A Pitsillides, John R Hutchinson
The appearance and shape of sesamoid bones within a tendon or ligament wrapping around a joint are understood to be influenced by both genetic and epigenetic factors. Ostriches (Struthio camelus) possess two sesamoid patellae (kneecaps), one of which (the distal patella) is unique to their lineage, making them a good model for investigating sesamoid tissue development and evolution. Here we used finite-element modelling to test the hypothesis that specific mechanical cues in the ostrich patellar tendon favour the formation of multiple patellae...
June 2017: Royal Society Open Science
keyword
keyword
75108
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"