keyword
MENU ▼
Read by QxMD icon Read
search

mechanobiology

keyword
https://www.readbyqxmd.com/read/29227567/the-dog-is-a-model-for-the-study-of-human-hip-dysplasia
#1
Cecilia Pascual-Garrido, Farshid Guilak, Muhammad Farooq Rai, Michael D Harris, Mandi J Lopez, Rory J Todhunter, John C Clohisy
Developmental dysplasia of the hip (DDH) in humans is a common condition that is associated with hip pain, functional limitations, and secondary osteoarthritis (OA). Surgical treatment of DDH has improved in the last decade, allowing excellent outcomes at short- and mid-term follow-up. Still, the etiology, mechanobiology, and pathology underlying this disease are not well understood. A pre-clinical animal model of DDH could help advance the field with a deeper understanding of specific pathways that initiate hip joint degeneration secondary to abnormal biomechanics...
December 11, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29225392/a-computational-analysis-of-bone-formation-in-the-cranial-vault-using-a-coupled-reaction-diffusion-strain-model
#2
Chanyoung Lee, Joan T Richtsmeier, Reuben H Kraft
Bones of the murine cranial vault are formed by differentiation of mesenchymal cells into osteoblasts, a process that is primarily understood to be controlled by a cascade of reactions between extracellular molecules and cells. We assume that the process can be modeled using Turing's reaction-diffusion equations, a mathematical model describing the pattern formation controlled by two interacting molecules (activator and inhibitor). In addition to the processes modeled by reaction-diffusion equations, we hypothesize that mechanical stimuli of the cells due to growth of the underlying brain contribute significantly to the process of cell differentiation in cranial vault development...
June 2017: Journal of Mechanics in Medicine and Biology
https://www.readbyqxmd.com/read/29224376/regulation-of-follicle-growth-through-hormonal-factors-and-mechanical-cues-mediated-by-hippo-signaling-pathway
#3
Ikko Kawashima, Kazuhiro Kawamura
The ovary is an interesting organ that shows major structural changes within a short period of time during each reproductive cycle. Follicle development is controlled by local paracrine and systemic endocrine factors. Many hormonal and molecular analyses have been conducted to find the mechanisms underlying structural changes in ovaries, However, exact mechanisms still remain to be determined. Recent development of mechanobiology facilitates the understanding on the contribution of physical forces and changes in the mechanical properties of cells and tissues to physiology and pathophysiology...
December 9, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29222565/biomechanics-and-mechanobiology-of-saphenous-vein-grafts
#4
Keith Gooch, Michael Firstenberg, Brittany Shrefler, Benjamin Scandling
Within several weeks of use as coronary artery bypass grafts (CABG), saphenous veins (SV) exhibit significant intimal hyperplasia (IH). The fact that SV do not develop significant IH in their native venous environment coupled with the rapidity with which they develop IH following grafting into the arterial circulation suggests that factors associated with the isolation and preparation of SV and/or differences between the venous and arterial environments contribute to disease progression. There is strong evidence suggesting that mechanical trauma associated with traditional techniques of SV preparation can significantly damage the vessel and might potentially reduce graft patency though modern surgical techniques reduces these injuries...
December 9, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29209171/influence-of-mechanical-stimuli-on-schwann-cell-biology
#5
REVIEW
Sophie Belin, Kristen L Zuloaga, Yannick Poitelon
Schwann cells are the glial cells of the peripheral nervous system (PNS). They insulate axons by forming a specialized extension of plasma membrane called the myelin sheath. The formation of myelin is essential for the rapid saltatory propagation of action potentials and to maintain the integrity of axons. Although both axonal and extracellular matrix (ECM) signals are necessary for myelination to occur, the cellular and molecular mechanisms regulating myelination continue to be elucidated. Schwann cells in peripheral nerves are physiologically exposed to mechanical stresses (i...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29208288/rhombicuboctahedron-unit-cell-based-scaffolds-for-bone-regeneration-geometry-optimization-with-a-mechanobiology-driven-algorithm
#6
Antonio Boccaccio, Michele Fiorentino, Antonio E Uva, Luca N Laghetti, Giuseppe Monno
In a context more and more oriented towards customized medical solutions, we propose a mechanobiology-driven algorithm to determine the optimal geometry of scaffolds for bone regeneration that is the most suited to specific boundary and loading conditions. In spite of the huge number of articles investigating different unit cells for porous biomaterials, no studies are reported in the literature that optimize the geometric parameters of such unit cells based on mechanobiological criteria. Parametric finite element models of scaffolds with rhombicuboctahedron unit cell were developed and incorporated into an optimization algorithm that combines them with a computational mechanobiological model...
February 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29195023/computational-modeling-of-single-cell-mechanics-and-cytoskeletal-mechanobiology
#7
REVIEW
Vijay Rajagopal, William R Holmes, Peter Vee Sin Lee
Cellular cytoskeletal mechanics plays a major role in many aspects of human health from organ development to wound healing, tissue homeostasis and cancer metastasis. We summarize the state-of-the-art techniques for mathematically modeling cellular stiffness and mechanics and the cytoskeletal components and factors that regulate them. We highlight key experiments that have assisted model parameterization and compare the advantages of different models that have been used to recapitulate these experiments. An overview of feed-forward mechanisms from signaling to cytoskeleton remodeling is provided, followed by a discussion of the rapidly growing niche of encapsulating feedback mechanisms from cytoskeletal and cell mechanics to signaling...
November 30, 2017: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/29183939/understanding-the-extracellular-forces-that-determine-cell-fate-and-maintenance
#8
REVIEW
Aditya Kumar, Jesse K Placone, Adam J Engler
Stem cells interpret signals from their microenvironment while simultaneously modifying the niche through secreting factors and exerting mechanical forces. Many soluble stem cell cues have been determined over the past century, but in the past decade, our molecular understanding of mechanobiology has advanced to explain how passive and active forces induce similar signaling cascades that drive self-renewal, migration, differentiation or a combination of these outcomes. Improvements in stem cell culture methods, materials and biophysical tools that assess function have improved our understanding of these cascades...
December 1, 2017: Development
https://www.readbyqxmd.com/read/29181720/development-of-a-platform-for-studying-3d-astrocyte-mechanobiology-compression-of-astrocytes-in-collagen-gels
#9
John J E Mulvihill, Julia Raykin, Eric J Snider, Lisa A Schildmeyer, Irsham Zaman, Manu O Platt, Daniel J Kelly, C Ross Ethier
Glaucoma is a common optic neuropathy characterized by retinal ganglion cell death. Elevated intraocular pressure (IOP), a key risk factor for glaucoma, leads to significant biomechanical deformation of optic nerve head (ONH) cells and tissues. ONH astrocytes respond to this deformation by transforming to a reactive, proliferative phenotype, which has been implicated in the progression of glaucomatous vision loss. However, little is known about the mechanisms of this transformation. In this study, we developed a 3D collagen gel culture system to mimic features of ONH deformation due to elevated IOP...
November 27, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29179947/why-we-need-mechanics-to-understand-animal-regeneration
#10
REVIEW
Kevin Chiou, Eva-Maria S Collins
Mechanical forces are an important contributor to cell fate specification and cell migration during embryonic development in animals. Similarities between embryogenesis and regeneration, particularly with regards to pattern formation and large-scale tissue movements, suggest similarly important roles for physical forces during regeneration. While the influence of the mechanical environment on stem cell differentiation in vitro is being actively exploited in the fields of tissue engineering and regenerative medicine, comparatively little is known about the role of stresses and strains acting during animal regeneration...
October 16, 2017: Developmental Biology
https://www.readbyqxmd.com/read/29178811/cell-ecm-mechanobiology-forceful-tools-and-emerging-needs-for-basic-and-translational-research
#11
Andrew W Holle, Jennifer L Young, Krystyn J Van Vliet, Roger D Kamm, Dennis E Discher, Paul A Janmey, Joachim P Spatz, M Taher Saif
Extracellular biophysical cues have a profound influence on a wide range of cell behaviors, including growth, motility, differentiation, apoptosis, gene expression, adhesion and signal transduction. Cells not only respond to definitively mechanical cues from the extracellular matrix (ECM), but can also sometimes alter the mechanical properties of the matrix and hence influence subsequent matrix-based cues in both physiological and pathological processes. Interactions between cells and materials in vitro can modify cell phenotype and ECM structure, whether intentionally or inadvertently...
November 27, 2017: Nano Letters
https://www.readbyqxmd.com/read/29176756/cryogenic-3d-printing-of-super-soft-hydrogels
#12
Zhengchu Tan, Cristian Parisi, Lucy Di Silvio, Daniele Dini, Antonio Elia Forte
Conventional 3D bioprinting allows fabrication of 3D scaffolds for biomedical applications. In this contribution we present a cryogenic 3D printing method able to produce stable 3D structures by utilising the liquid to solid phase change of a composite hydrogel (CH) ink. This is achieved by rapidly cooling the ink solution below its freezing point using solid carbon dioxide (CO2) in an isopropanol bath. The setup was able to successfully create 3D complex geometrical structures, with an average compressive stiffness of O(1) kPa (0...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29170549/designer-biomaterials-for-mechanobiology
#13
Linqing Li, Jeroen Eyckmans, Christopher S Chen
No abstract text is available yet for this article.
November 24, 2017: Nature Materials
https://www.readbyqxmd.com/read/29150470/platelet-rich-plasma-in-achilles-tendon-healing-2-path-2-trial-protocol-for-a-multicentre-participant-and-assessor-blinded-parallel-group-randomised-clinical-trial-comparing-platelet-rich-plasma-prp-injection-versus-placebo-injection-for-achilles-tendon-rupture
#14
Joseph Alsousou, David J Keene, Philippa A Hulley, Paul Harrison, Susan Wagland, Christopher Byrne, Michael Maia Schlüssel, Susan J Dutton, Sarah E Lamb, Keith Willett
BACKGROUND: Achilles tendon injuries give rise to substantial long-lasting morbidity and pose considerable challenges for clinicians and patients during the lengthy healing period. Current treatment strategies struggle to curb the burden of this injury on health systems and society due to lengthy rehabilitation, work absence and reinjury risk. Platelet-rich plasma (PRP) is an autologous preparation that has been shown to improve the mechanobiological properties of tendons in laboratory and animal studies...
November 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29137624/compression-rate-dependent-nonlinear-mechanics-of-normal-and-impaired-porcine-knee-joints
#15
Marcel Leonardo Rodriguez, LePing Li
BACKGROUND: The knee joint performs mechanical functions with various loading and unloading processes. Past studies have focused on the kinematics and elastic response of the joint with less understanding of the rate-dependent load response associated with viscoelastic and poromechanical behaviors. METHODS: Forty-five fresh porcine knee joints were used in the present study to determine the loading-rate-dependent force-compression relationship, creep and relaxation of normal, dehydrated and meniscectomized joints...
November 14, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29125824/intraluminal-valves-development-function-and-disease
#16
REVIEW
Xin Geng, Boksik Cha, Md Riaj Mahamud, R Sathish Srinivasan
The circulatory system consists of the heart, blood vessels and lymphatic vessels, which function in parallel to provide nutrients and remove waste from the body. Vascular function depends on valves, which regulate unidirectional fluid flow against gravitational and pressure gradients. Severe valve disorders can cause mortality and some are associated with severe morbidity. Although cardiac valve defects can be treated by valve replacement surgery, no treatment is currently available for valve disorders of the veins and lymphatics...
November 1, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29115301/mechanical-forces-direct-stem-cell-behaviour-in-development-and-regeneration
#17
REVIEW
Kyle H Vining, David J Mooney
Stem cells and their local microenvironment, or niche, communicate through mechanical cues to regulate cell fate and cell behaviour and to guide developmental processes. During embryonic development, mechanical forces are involved in patterning and organogenesis. The physical environment of pluripotent stem cells regulates their self-renewal and differentiation. Mechanical and physical cues are also important in adult tissues, where adult stem cells require physical interactions with the extracellular matrix to maintain their potency...
November 8, 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/29115298/mechanobiology-of-collective-cell-behaviours
#18
REVIEW
Benoit Ladoux, René-Marc Mège
The way in which cells coordinate their behaviours during various biological processes, including morphogenesis, cancer progression and tissue remodelling, largely depends on the mechanical properties of the external environment. In contrast to single cells, collective cell behaviours rely on the cellular interactions not only with the surrounding extracellular matrix but also with neighbouring cells. Collective dynamics is not simply the result of many individually moving blocks. Instead, cells coordinate their movements by actively interacting with each other...
November 8, 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/29097692/quantitative-structural-mechanobiology-of-platelet-driven-blood-clot-contraction
#19
Oleg V Kim, Rustem I Litvinov, Mark S Alber, John W Weisel
Blood clot contraction plays an important role in prevention of bleeding and in thrombotic disorders. Here, we unveil and quantify the structural mechanisms of clot contraction at the level of single platelets. A key elementary step of contraction is sequential extension-retraction of platelet filopodia attached to fibrin fibers. In contrast to other cell-matrix systems in which cells migrate along fibers, the "hand-over-hand" longitudinal pulling causes shortening and bending of platelet-attached fibers, resulting in formation of fiber kinks...
November 2, 2017: Nature Communications
https://www.readbyqxmd.com/read/29093676/bioinspired-technologies-to-connect-musculoskeletal-mechanobiology-to-the-person-for-training-and-rehabilitation
#20
REVIEW
Claudio Pizzolato, David G Lloyd, Rod S Barrett, Jill L Cook, Ming H Zheng, Thor F Besier, David J Saxby
Musculoskeletal tissues respond to optimal mechanical signals (e.g., strains) through anabolic adaptations, while mechanical signals above and below optimal levels cause tissue catabolism. If an individual's physical behavior could be altered to generate optimal mechanical signaling to musculoskeletal tissues, then targeted strengthening and/or repair would be possible. We propose new bioinspired technologies to provide real-time biofeedback of relevant mechanical signals to guide training and rehabilitation...
2017: Frontiers in Computational Neuroscience
keyword
keyword
75108
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"