Karolina A P Wijnands, Dennis M Meesters, Kevin W Y van Barneveld, Ruben G J Visschers, Jacob J Briedé, Benjamin Vandendriessche, Hans M H van Eijk, Babs A F M Bessems, Nadine van den Hoven, Christian J H von Wintersdorff, Peter Brouckaert, Nicole D Bouvy, Wouter H Lamers, Anje Cauwels, Martijn Poeze
Enhanced arginase-induced arginine consumption is believed to play a key role in the pathogenesis of sickle cell disease-induced end organ failure. Enhancement of arginine availability with L-arginine supplementation exhibited less consistent results; however, L-citrulline, the precursor of L-arginine, may be a promising alternative. In this study, we determined the effects of L-citrulline compared to L-arginine supplementation on arginine-nitric oxide (NO) metabolism, arginine availability and microcirculation in a murine model with acutely-enhanced arginase activity...
July 2015: Nutrients