Silvia Diviccaro, Monika Herian, Lucia Cioffi, Matteo Audano, Nico Mitro, Donatella Caruso, Silvia Giatti, Roberto Cosimo Melcangi
Despite its efficacy for treating androgenetic alopecia, finasteride, an inhibitor of 5α-reductase (i.e., the enzyme converting testosterone, T, into dihydrotestosterone, DHT), is associated with several side effects including sexual dysfunction (e.g., erectile dysfunction). These side effects may persist after drug suspension, inducing the so-called post-finasteride syndrome (PFS). The effects of subchronic treatment with finasteride (i.e., 20 days) and its withdrawal (i.e., 1 month) in rat corpus cavernosum have been explored here...
August 24, 2023: Andrology