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fever neutropenia

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https://www.readbyqxmd.com/read/29462193/the-influence-of-different-fever-definitions-on-diagnostics-and-treatment-after-diagnosis-of-fever-in-chemotherapy-induced-neutropenia-in-children-with-cancer
#1
Stéphanie Wagner, Eva K Brack, Eveline Stutz-Grunder, Philipp Agyeman, Kurt Leibundgut, Oliver Teuffel, Roland A Ammann
BACKGROUND: There is no evidence-based definition of the temperature limit defining fever (TLDF) in children with neutropenia. Lowering the TLDF is known to increase the number of episodes of fever in neutropenia (FN). This study aimed to investigate the influence of a lower versus standard TLDF on diagnostics and therapy. METHODS: In a single pediatric cancer center using a high standard TLDF (39°C tympanic-temperature) patients were observed prospectively (NCT01683370)...
2018: PloS One
https://www.readbyqxmd.com/read/29461916/outpatient-management-of-fever-and-neutropenia-in-adults-treated-for-malignancy-american-society-of-clinical-oncology-and-infectious-diseases-society-of-america-clinical-practice-guideline-update
#2
Randy A Taplitz, Erin B Kennedy, Eric J Bow, Jennie Crews, Charise Gleason, Douglas K Hawley, Amelia A Langston, Loretta J Nastoupil, Michelle Rajotte, Kenneth Rolston, Lynne Strasfeld, Christopher R Flowers
Purpose To provide an updated joint ASCO/Infectious Diseases Society of American (IDSA) guideline on outpatient management of fever and neutropenia in patients with cancer. Methods ASCO and IDSA convened an Update Expert Panel and conducted a systematic review of relevant studies. The guideline recommendations were based on the review of evidence by the Expert Panel. Results Six new or updated meta-analyses and six new primary studies were added to the updated systematic review. Recommendations Clinical judgment is recommended when determining which patients are candidates for outpatient management, using clinical criteria or a validated tool such as the Multinational Association of Support Care in Cancer risk index...
February 20, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29456976/respiratory-viruses-in-febrile-neutropenic-patients-with-respiratory-symptoms
#3
Mohsen Meidani, Seyed Alireza Mirmohammad Sadeghi
Background: Respiratory infections are a frequent cause of fever in neutropenic patients, whereas respiratory viral infections are not frequently considered as a diagnosis, which causes high morbidity and mortality in these patients. Materials and Methods: This prospective study was performed on 36 patients with neutropenia who admitted to hospital were eligible for inclusion with fever (single temperature of >38.3°C or a sustained temperature of >38°C for more than 1 h), upper and lower respiratory symptoms...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29451055/early-discontinuation-of-empirical-antibacterial-therapy-in-febrile-neutropenia-the-antibiostop-study
#4
Lenaïg Le Clech, Jean-Philippe Talarmin, Marie-Anne Couturier, Jean-Christophe Ianotto, Christophe Nicol, Ronan Le Calloch, Stéphanie Dos Santos, Pascal Hutin, Didier Tandé, Virginie Cogulet, Christian Berthou, Gaëlle Guillerm
INTRODUCTION: Immediate empirical antibiotic therapy is mandatory in febrile chemotherapy-induced neutropenia, but its optimal duration is unclear, especially in patients with fever of unknown origin (FUO). OBJECTIVES: The primary objective of this 20-month prospective observational study was to evaluate the feasibility and safety of short-term antibiotic treatment in afebrile or febrile patients exhibiting FUO, irrespective of their neutrophil count. The secondary objective was to describe the epidemiology of all episodes of febrile neutropenia...
February 16, 2018: Infectious Diseases
https://www.readbyqxmd.com/read/29429482/enteric-coronavirus-infection-in-adult-horses
#5
N Pusterla, R Vin, C M Leutenegger, L D Mittel, T J Divers
A new enteric virus of adult horses, equine coronavirus (ECoV), has recently been recognized. It is associated with fever, lethargy, anorexia, and less frequently, colic and diarrhea. This enteric virus is transmitted via the feco-oral route and horses become infected by ingesting fecally contaminated feed and water. Various outbreaks have been reported since 2010 from Japan, Europe and the USA. While the clinical signs are fairly non-specific, lymphopenia and neutropenia are often seen. Specific diagnosis is made by the detection of ECoV in feces by either quantitative real-time PCR, electron microscopy or antigen-capture ELISA...
January 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29411126/febrile-events-in-acute-lymphoblastic-leukemia-a-prospective-observational-multicentric-seifem-study-seifem-2012-b-all
#6
Roberta Di Blasi, Chiara Cattaneo, Russell E Lewis, Mario Tumbarello, Laura Angelici, Giulia Dragonetti, Alessandro Busca, Benedetta Cambò, Anna Candoni, Monica Cesarini, Simone Cesaro, Mario Delia, Rosa Fanci, Francesca Farina, Mariagrazia Garzia, Antonio Giordano, Bruno Martino, Lorella Melillo, Gianpaolo Nadali, Vincenzo Perriello, Marco Picardi, Angela Maria Quinto, Prassede Salutari, Angelica Spolzino, Adriana Vacca, Calogero Vetro, Michelle Zancanella, Annamaria Nosari, Franco Aversa, Livio Pagano
The purpose of the present study is to estimate the current incidence of febrile events (FEs) and infectious episodes in acute lymphoblastic leukemia (ALL) and evaluate the outcome. We analyzed data on all FEs in a cohort of patients affected by ALL admitted to 20 Italian hematologic centers during 21 months of observation from April 1, 2012 to December 31, 2013. Data about treatment phase, steroids, neutropenia, type and site of infection, and outcome of infection were collected. The population comprehended 271 ALL adult patients...
February 7, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29394975/sofosbuvir-adverse-events-profile-in-a-subset-of-pakistani-population
#7
Sarwat Iqbal, Muhammad Haroon Yousuf, Ayeha Raza, Muhammad Iftikhar Yousaf
OBJECTIVE: To determine frequency and pattern of adverse events reporting in a subset of Pakistani population being treated for chronic hepatitis C with sofosbuvir combination therapy. STUDY DESIGN: Descriptive study. PLACE AND DURATION OF STUDY: Department of Medicine, Gastroenterology Division, Shalamar Hospital, Lahore, from September 2015 to May 2016. METHODOLOGY: Patients who were offered sofosbuvir therapy for treatment of chronic hepatitis C were randomly enrolled...
February 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29355731/human-babesiosis-in-southeast-china-a-case-report
#8
Shanshan Huang, Lingling Zhang, Linong Yao, Jie Li, Hui Chen, Qingxiang Ni, Chenwei Pan, Lingxiang Jin
A 60-year-old female patient living in southeastern China presented with persistent fever, chills, night sweats, fatigue and dizziness for 12 days. Blood tests showed neutropenia, thrombocytopenia and active hemolytic anemia with elevated C-reactive protein. Broad spectrum antibiotics for a possible diagnosis of sepsis were administered without any response. Malaria was diagnosed initially after visualizing intraerythrocytic ring shaped parasites in bone marrow and blood smears. The region the patient lived in was an area of unstable endemicity for Plasmodium falciparum...
January 17, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29349917/risk-stratification-for-febrile-neutropenia-in-patients-with-testicular-germ-cell-tumors
#9
Angelika Terbuch, Florian Posch, Richard Partl, Brigitte Zurl, Thomas Bauernhofer, Martin Pichler, Joanna Szkandera, Georg C Hutterer, Karl Pummer, Karin S Kapp, Herbert Stöger, Armin Gerger, Michael Stotz
The aim of this study was to detect risk factors for febrile neutropenia (FN) in patients with testicular germ cell tumors (TGCT). In this retrospective cohort study at the Medical University of Graz, we included 413 consecutive TGCT patients who received adjuvant or curative treatment with cisplatin-based chemotherapy. FN occurred in 70 (16.9%) of 413 patients. In univariable logistic regression, higher age (odds ratio (OR) per 5 years = 1.17, 95% CI: 1.02-1.35, P = 0.022), reduced performance status (PS) (OR = 2...
January 19, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29334532/cost-effectiveness-and-improved-parent-and-provider-satisfaction-with-outpatient-management-of-pediatric-oncology-patients-with-low-risk-fever-and-neutropenia
#10
Abhishek Bavle, Amanda Grimes, Sibo Zhao, Daniel Zinn, Andrea Jackson, Binita Patel, Timothy Porea, Ankhi Dutta, Heidi Russell, Andras Heczey
On the basis of significant evidence for safety, the international pediatric fever and neutropenia committee recommends the identification and management of patients with "low-risk fever and neutropenia" (LRFN), outpatient with oral antibiotics, instead of traditional inpatient management. The aim of our study was to compare the cost-per-patient with these 2 strategies, and to evaluate parent and provider satisfaction with the outpatient management of LRFN. Between March 2016 and February 2017, 17 LRFN patients (median absolute neutrophil count, 90/μL) were managed at a single institution, per new guidelines...
January 12, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29322242/utility-of-fosfomycin-as-antibacterial-prophylaxis-in-patients-with-hematologic-malignancies
#11
Tanya Zapolskaya, Sarah Perreault, Dayna McManus, Jeffrey E Topal
PURPOSE: Prolonged and profound neutropenia is common among hematology and hematopoietic stem cell transplant (HSCT) patients as a result of chemotherapy. The National Comprehensive Cancer Network (NCCN) and Infectious Diseases Society of America (IDSA) currently recommend antibacterial prophylaxis in patients who are deemed at intermediate or high risk for infection. Specifically, fluoroquinolone prophylaxis should be considered for high-risk neutropenic patients. However, with prolonged and frequent exposure to fluoroquinolones, these high-risk patients may develop resistance to these agents...
January 10, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29319583/the-infectious-and-non-infectious-etiology-clinical-picture-and-outcome-of-neutropenia-in-immunocompetent-hospitalized-children
#12
Odeya David, Yariv Fruchtman, Ruslan Sergienko, Joseph Kapelushnik, Eugene Leibovitz
BACKGROUND: Acquired neutropenia in immunocompetent children is common and its differential diagnosis ranges from benign causes to life-threatening diseases. We described the etiology, clinical picture and outcome of new onset neutropenia in immunocompetent children assessed in the emergency department and hospitalized at our medical center. PATIENTS AND METHODS: Previously healthy children admitted with neutropenia (absolute neutrophil count [ANC] <1.5 x 10/L) were included...
January 9, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29310697/epidemiology-genetic-variants-and-clinical-course-of-natural-infections-with-anaplasma-phagocytophilum-in-a-dairy-cattle-herd
#13
Cornelia Silaghi, Marion Nieder, Carola Sauter-Louis, Gabriela Knubben-Schweizer, Kurt Pfister, Martin Pfeffer
BACKGROUND: Anaplasma phagocytophilum is an obligate intracellular, tick-transmitted bacterium that causes granulocytic anaplasmosis in humans and several mammalian species including domestic ruminants where it is called tick-borne fever (TBF). Different genetic variants exist but their impact with regard to putative differences in host associations and pathogenicity are not yet completely understood. METHODS: Natural infections with A. phagocytophilum in a dairy cattle herd in Germany were investigated over one pasture season by using serology, haematology, blood chemistry and polymerase chain reaction (PCR)...
January 8, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29310512/moxifloxacin-versus-levofloxacin-for-antibacterial-prophylaxis-in-acute-leukemia-patients
#14
Pauline Lee, Randall W Knoebel, Jennifer Pisano, Natasha N Pettit
Objective The primary endpoint of this study was to determine the incidence of febrile neutropenia among patients receiving either moxifloxacin or levofloxacin for antibacterial prophylaxis. Secondary endpoints were number of documented infections and in-hospital mortality in patients who develop febrile neutropenia. Methods A single-center retrospective cohort analysis at a large tertiary care academic medical center was conducted. This study included adult acute leukemia patients (age ≥18 years old) who received inpatient antibacterial prophylaxis (moxifloxacin or levofloxacin) from 1 July 2012 to 1 October 2014...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29299882/-about-98-cases-of-dengue-hospitalized-in-a-private-clinic-of-ouagadougou-epidemiology-diagnostic-and-evolution
#15
I Diallo, K A Sondo, H Tieno, E Y Tamelokpo, J Zoungrana, Y Sagna, M Savadogo, A Poda, O Guira, E A Diendéré, J Sakandé, Y J Drabo
Extremely widespread, the dengue is a reemerging infectious disease. In Burkina Faso, dengue is a reality that was little known. The aim of this study was to study epidemiology, diagnostic and outcomes of dengue patients in Ouagadougou. A retrospective study covered a period of two years, from 1 January 2013 to 31 December 2014 in a private clinic in Ouagadougou. Patients included in the study were hospitalized for fever and painful syndrome with a positive test to the dengue non-structural antigen 1 (NS1 Ag)...
December 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/29286213/risk-factors-for-invasive-fungal-infection-among-thai-oncologic-patients-with-febrile-neutropenia-and-cutaneous-presentation-a-5-year-retrospective-study-in-southern-thailand
#16
Kumpol Aiempanakit, Surarit Naorungroj, Kanokphorn Chiratikarnwong, Sauvarat Auepemkiate, Benjawan Apinantriyo
Background: Febrile neutropenia (FNP) is a condition defined by fever and neutropenia. There are current only limited data on related cutaneous manifestations. This study aimed to assess cutaneous lesions and their etiologies in a Thai group of FNP patients. Methods: A retrospective analysis was conducted on 43 non-transplant febrile neutropenic patients with concurrent cutaneous lesions, as determined by dermatopathologic studies at Songklanagarind Hospital in Thailand over a five-year period. Results: The mean age was 39 years (SD: 18...
December 29, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29281994/successful-treatment-of-cerebral-aspergillosis-case-report-of-a-patient-with-t-cell-large-granular-lymphocytic-leukemia-t-lgl
#17
Amin T Turki, Jassin Rashidi-Alavijeh, Jan Dürig, Guido Gerken, Peter-Michael Rath, Oliver Witzke
BACKGROUND: Invasive aspergillosis involving patients with neutropenia or severe immunosuppression, such as patients with hematologic malignancies is associated with high mortality. Patients with T-cell large granular lymphocytic leukemia (T-LGL) on the other hand are considered to be less vulnerable for severe opportunistic fungal infection as their course of disease is chronic and marked by less violent cytopenia then in e.g. Aplastic Anemia. Only neutropenia is regarded as independent risk factor for severe opportunistic infection in T-LGL patients...
December 28, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29242012/outcomes-of-immunocompetent-children-presenting-with-fever-and-neutropenia
#18
Osnat Wittmann, Ayelet Rimon, Dennis Scolnik, Miguel Glatstein
BACKGROUND: Neutropenia may alarm clinicians and prompt extensive evaluation in children with fever, even in immunocompetent patients. OBJECTIVE: Our aim was to determine outcomes in previously healthy febrile children presenting to the emergency department with severe neutropenia. METHODS: We reviewed data from infants and children aged 3-36 months with fever and severe neutropenia, defined as a peripheral neutrophil count <500 × 103/μL, at our institution between January 1, 2012 and December 31, 2015...
December 11, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29240030/a-case-of-familial-mediterranean-fever-having-intermittent-leukopenia
#19
Ilke Beyitler, Salih Kavukcu
Familial Mediterranean fever (FMF) is a genetically inherited autoinflammatory disorder characterized by inflammatory attacks and may result in amyloidosis as a severe complication. Elevation of acute phase reactants, including leukocytosis, is seen during attack periods. Here we describe a 13-year-old female patient with a very rare clinical presentation of FMF, who would experience FMF attacks when she did not regularly take her colchicine. During these attacks she had leukopenia and neutropenia instead of leukocytosis...
December 12, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29228331/clinical-characteristics-and-outcomes-of-patients-with-chronic-disseminated-candidiasis-who-need-adjuvant-corticosteroid-therapy
#20
Young-Rock Jang, Min-Chul Kim, Taeeun Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Jung Yong Hong, Dok Hyun Yoon, Cheolwon Suh, Jung-Hee Lee, Je-Hwan Lee, Kyoo-Hyung Lee, Sung-Han Kim
We performed a retrospective study involving 21 patients with chronic disseminate candidiasis (CDC) and 38 patients with candidemia. Neutropenia of >2 weeks' duration was more common in those with CDC (71%) than in those with candidemia (26%, P < .001), and the azole-resistant rate in patients with CDC (5%) was lower than that in those with candidemia (29%, P = .03). Of the 21 patients with CDC, five (24%) needed adjuvant corticosteroid therapy due to persistent debilitating fever (median, 19 days). Rapid defervescence (median, 5 days) occurred after adjuvant corticosteroid therapy...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
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