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https://www.readbyqxmd.com/read/28330254/enhanced-production-of-an-anti-malarial-compound-artesunate-by-hairy-root-cultures-and-phytochemical-analysis-of-artemisia-pallens-wall
#1
Zarna Pala, Vishnu Shukla, Anshu Alok, Subhash Kudale, Neetin Desai
Artemisinin and its derivatives are still one of the most effective drugs for the treatment of malaria. Artemisia pallens commonly known as Dhavanam, is an aromatic herb belonging to the family Asteraceae. Increasing the artemisinin content of A. pallens by genetic engineering would improve the availability of this much needed drug. In the present study, Agrobacterium rhizogenes (strain NCIM 5140) mediated genetic transformation of Artemisia pallens were carried out for hairy root induction. The effect of different media (Half MS, MS, MS along with BAP 0...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28323099/nanohydrogel-with-n-n-bis-acryloyl-cystine-crosslinker-for-high-drug-loading
#2
Marcin Mackiewicz, Jan Romanski, Ewa Drozd, Beata Gruber-Bzura, Piotr Fiedor, Zbigniew Stojek, Marcin Karbarz
Substantially improved hydrogel particles based on poly(N-isopropylacrylamide) (pNIPA) have been obtained. First, as a result of replacing commercially available N,N'-bis(acryloyl)cystamine (BAC), the crosslinker, with acryloyl derivative of cystine containing a carboxylic group (BISS), the hydrogel particles acquired improved stability vs. ionic strength and allowed further chemical modification of the chains, including the attachment of drug molecules. Next, a redox-initiated aqueous precipitation polymerization via the semi-batch method was used...
March 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28321530/pregnancy-in-patients-with-thalassemia-major-a-cohort-study-and-conclusions-for-an-adequate-care-management-approach
#3
E Cassinerio, I M Baldini, R S Alameddine, A Marcon, R Borroni, W Ossola, A Taher, M D Cappellini
An improvement in quality of life and survival occurred among thalassemia major (TM) patients: pregnancy in such patients has become a reality. Safe pregnancy and delivery require efforts to ensure the best outcomes. Between 2007 and 2016, 30 TM patients had 37 pregnancies. We analyzed the hematological parameters before, during, and after pregnancies and in 19 patients a cardiovascular magnetic resonance (CMR) T2* was performed. The mean age at first pregnancy was 30 ± 4 years; the current mean age is 35 ± 5 years...
March 20, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28320622/heavy-metal-concentrations-and-arsenic-speciation-in-animal-manure-composts-in-china
#4
Xinping Yang, Qian Li, Zhu Tang, Wenwen Zhang, Guanghui Yu, Qirong Shen, Fang-Jie Zhao
A nationwide survey of animal manure-based composts was carried out in China. Two hundred and twelve samples were collected and analyzed for the concentrations of 9 heavy metals or metalloids and arsenic (As) speciation. The concentrations of heavy metals vary widely (Zn 11.8-3692, Cu 3.6-916, Cr 0.7-6603, Ni 0.7-73, Pb 0.05-189, As 0.4-72, Co 0.1-94, Cd 0.01-8.7 and Hg 0.01-1.9mgkg(-1) dry weight). Compared with the maximum permissible values of the Chinese standard for organic fertilizers, 13.7% and 2.4% of the composts exceeded the limits for As (15mgkg(-1)) and Cd (3mgkg(-1)), respectively...
March 17, 2017: Waste Management
https://www.readbyqxmd.com/read/28317232/soil-parent-material-a-major-driver-of-plant-nutrient-limitations-in-terrestrial-ecosystems
#5
Laurent Augusto, David L Achat, Mathieu Jonard, David Vidal, Bruno Ringeval
Because the capability of terrestrial ecosystems to fix carbon is constrained by nutrient availability, understanding how nutrients limit plant growth is a key contemporary question. However, what drives nutrient limitations at global scale remains to be clarified. Using global data on plant growth, plant nutritive status, and soil fertility, we investigated to which extent soil parent materials explain nutrient limitations. We found that N limitation was not linked to soil parent materials, but was best explained by climate: ecosystems under harsh (i...
March 19, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28315984/thermomechanical-method-for-cement-extraction-in-revision-arthroplasty
#6
M Ghanem, A Koenig, F Dehn, C-E Heyde, C Josten
BACKGROUND: In joint revision surgery, bone cement extraction remains a major challenge which even today has not seen a satisfactory solution yet. We studied in an experimental setting the impact of heat sources on the mechanical properties and microstructure of bone cement and determined the glass transition temperature (T G) of bone cement. As a result, it would be possible to establish a thermomechanical method which makes use of the structural and material-specific property changes inherent in bone cement at elevated temperatures...
March 18, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28315496/remeex-device-external-mechanical-regulator-for-female-stress-urinary-incontinence-a-critical-review-of-a-single-operator-long-term-experience-on-implants-and-readjustments
#7
Franco Mantovani
OBJECTIVE: A single-operator, long-term (15 years) experience on a sling technique that allows a postoperative adjustment of its tension is presented to retrospectively report the objective and subjective outcomes in the treatment of female stress urinary incontinence (SUI). The readjustment option prevents the need of a reoperation in case of relapse with great compliance of the patients. MATERIALS AND METHODS: Indications for surgical tratment of SUI by ReMeEx included patients affected with not only true intrinsic sphyncteric deficency (ISD) and fixed urethra but also mild urethral hypermobility, previous incontinence surgery and relapsing conditions such as diabetes and obesity...
March 18, 2017: Urologia
https://www.readbyqxmd.com/read/28306360/the-antibiotic-pipeline-reviving-research-and-development-and-speeding-drugs-to-market
#8
Katherine H Luepke, John F Mohr
The combination of growing antimicrobial resistance with a dry pipeline has resulted in infections that can no longer be treated. Specific reasons have led to companies' exit from the antibacterial space, however recent incentives are spurring interest to reinvigorate the pipeline. Areas Covered: This article summarizes the available information on the discovery, developmental, and regulatory challenges in antibacterial development that have led to disinterest in the space, as well as ongoing incentives such as public-private partnerships and streamlined pathways to mend these challenges and bring new antibiotics to patients in need...
March 17, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28306250/co2-selective-absorbents-in-air-reverse-lipid-bilayer-structure-forming-neutral-carbamic-acid-in-water-without-hydration
#9
Fuyuhiko Inagaki, Chiaki Matsumoto, Takashi Iwata, Chisato Mukai
Emission gas and air contain not only CO2 but also plentiful moisture, making it difficult to achieve selective CO2 absorption without hydration. To generate absorbed CO2 (wet CO2) under heating, the need for external energy to release the absorbed water has been among the most serious problems in the fields of carbon dioxide capture and storage (CCS) and direct air capture (DAC). We found that the introduction of the hydrophobic phenyl group into alkylamines of CO2 absorbents improved the absorption selectivity between CO2 and water...
March 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28304413/carbon-nanotube-thin-film-transistors-fabricated-by-an-etching-based-manufacturing-compatible-process
#10
Boyuan Tian, Xuelei Liang, Jiye Xia, Han Zhang, Guodong Dong, Qi Huang, Lianmao Peng, Sishen Xie
Carbon nanotube thin film transistors (CNT-TFTs) have been regarded as strong competitors to currently commercialized TFT technologies. Though much progress has been achieved recently, CNT-TFT research is still in the stage of laboratory research. One critical challenge for commercializing CNT-TFT technology is that the commonly used device fabrication method is a lift-off based process, which is not suitable for mass production. In this paper, we report an etching based fabrication process for CNT-TFTs, which is fully manufacturing compatible...
March 17, 2017: Nanoscale
https://www.readbyqxmd.com/read/28299406/evaluation-of-the-health-status-of-the-silverside-odontesthes-bonariensis-at-a-ramsar-site-in-south-america
#11
M L Ballesteros, A C Hued, M Gonzalez, K S B Miglioranza, M A Bistoni
The objective of this work was to evaluate the health status of an economic and ecologically important fish species from Mar Chiquita Lake, a RAMSAR site located in Cordoba, Argentina, relative to the levels of selected persistent organic pollutants (POPs) in lake water and fish tissues. Odontesthes bonariensis was used as a model species, and its health was estimated by means of histological indices in gills and liver. Sampling was performed according to rainy and dry seasons (i.e. dry, rainy and post-rainy)...
March 16, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28295578/measurement-of-acetabular-version-based-on-biplanar-radiographs-with-3d-reconstructions-in-comparison-to-ct-as-reference-standard-in-cadavers
#12
Christoph A Agten, Maciej Jonczy, Oliver Ullrich, Christian W A Pfirrmann, Reto Sutter, Florian M Buck
INTRODUCTION: To quantify acetabular version using 3D reconstructions based on biplanar radiographs (BPR) with CT as reference standard. MATERIALS AND METHODS: No institutional review board approval was needed. Nine dry-bone pelvises underwent BPR in five different positions (rotation/tilt). 3D models of each pelvis were reconstructed by two radiologists on the basis of anatomical landmarks using semi-automated software. Automated software was used to assess the 3D models and to calculate acetabular versions perpendicular to the anterior pelvic plane on all levels in the craniocaudal direction in 1mm steps...
March 13, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28294500/geographical-variation-and-the-role-of-climate-in-leaf-traits-of-a-relic-tree-species-across-its-distribution-in-china
#13
Hongjie Meng, Xinzeng Wei, Scott B Franklin, Hao Wu, Mingxi Jiang
1.Intraspecific trait variation and trait-climate relationships are crucial for understanding a species' response to climate change. However, these phenomena have been rarely studied for tree species. Euptelea pleiospermum (E. pleiospermum) is a relic tree species with a wide distribution in China that offers a novel opportunity to examine such relationships. 2.Here, we measured 13 leaf traits of E. pleiospermum in 20 sites across its natural distribution in China. We investigated the extent of trait variation at local and regional scales, and developed geographic and climatic models to explain trait variation at the regional scale...
March 13, 2017: Plant Biology
https://www.readbyqxmd.com/read/28285981/novel-budesonide-particles-for-dry-powder-inhalation-dpi-prepared-using-a-microfluidic-reactor-coupled-with-ultrasonic-spray-freeze-drying
#14
Denis Saboti, Uroš Maver, Hak-Kim Chan, Odon Planinšek
Budesonide is a potent active pharmaceutical ingredient, often administered using respiratory devices such as metered dose inhalers (MDI), nebulizers and dry powder inhalers (DPI). Inhalable drug particles are conventionally produced by crystallization followed by milling. This approach tends to generate partially amorphous materials that require post-processing to improve the formulations' stability. Other methods involve homogenization or precipitation and often require the use of stabilizers, mostly surfactants...
March 9, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28285661/colonization-and-beneficial-effects-on-annual-ryegrass-by-mixed-inoculation-with-plant-growth-promoting-bacteria
#15
Nádia L Castanheira, Ana Catarina Dourado, Isabel Pais, José Semedo, Paula Scotti-Campos, Nuno Borges, Gilda Carvalho, Maria Teresa Barreto Crespo, Paula Fareleira
Multi-strain inoculants have increased potential to accomplish a diversity of plant needs, mainly attributed to its multi-functionality. This work evaluated the ability of a mixture of three bacteria to colonize and induce a beneficial response on the pasture crop annual ryegrass. Pseudomonas G1Dc10 and Paenibacillus G3Ac9 were previously isolated from annual ryegrass and were selected for their ability to perform multiple functions related to plant growth promotion. Sphingomonas azotifigens DSMZ 18530(T) was included due to nitrogen fixing ability...
May 2017: Microbiological Research
https://www.readbyqxmd.com/read/28282672/all-arthroscopic-autologous-matrix-induced-chondrogenesis-aided-repair-of-a-patellar-cartilage-defect-using-dry-arthroscopy-and-a-retraction-system
#16
Boguslaw Sadlik, Mariusz Puszkarz, Lidia Kosmalska, Martin Wiewiorski
The technique of all-arthroscopic autologous matrix-induced chondrogenesis (AMIC)-aided repair of patellar cartilage lesions using a retraction system and dry arthroscopy has been recently described. We report the first clinical and radiological data at a short-term follow-up. Twelve patients underwent AMIC-aided cartilage repair for a patellar lesion. All steps of the procedure were performed arthroscopically, which include the use of an intra-articularly placed retraction plate for distraction of the patellofemoral joint and evacuation of saline solution for collagen matrix insertion and fixation...
March 10, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28282067/evaluation-of-dry-eye-and-meibomian-gland-dysfunction-with-meibography-in-vitiligo
#17
M Palamar, P Kiyat, I Ertam, A Yagci
PurposeTo evaluate the dry eye and meibomian gland dysfunction (MGD) of vitiligo patients with meibography.MethodsTwenty eyes of 20 vitiligo patients (Group 1) and 20 eyes of 20 healthy individuals (Group 2) were enrolled. All subjects had undergone a comprehensive ophthalmic examination including corneal and conjunctival fluorescein staining (Oxford scale scoring), tear film break-up time (T-BUT), Schirmer 1 test, Ocular Surface Disease Index (OSDI) score assessment, and upper and lower eyelid meibography using infrared captures of a biomicroscope (Topcon, SL-D701, IJssel, The Netherlands)...
March 10, 2017: Eye
https://www.readbyqxmd.com/read/28270706/patients-with-burning-mouth-sensations-a-clinical-investigation-of-causative-factors-in-a-group-of-compete-denture-wearers-jordanian-population
#18
Gadeer Elea Mukatash-Nimri, Marwan A Al-Nimri, Omar G Al-Jadeed, Zaid R Al-Zobe, Khuzama K Aburumman, Nader A Masarwa
AIM: To find out the prevalence of "true" burning mouth syndrome and study the association between patients' spontaneous complaints of burning mouth and systemic conditions in a group of middle age and elderly "denture wearers" patients in Jordan. METHODS: A group of 129 patients (112 female and 17 male) of "complete denture wearers" subjects aged 40 years and over attended prosthetic clinic at King Hussein Medical Hospital complaining from oral burning, with no oral lesion possibly responsible for the burning sensations were selected...
January 2017: Saudi Dental Journal
https://www.readbyqxmd.com/read/28270542/effects-of-heat-and-moisture-exchangers-and-exhaled-humidity-on-aerosol-deposition-in-a-simulated-ventilator-dependent-adult-lung-model
#19
Arzu Ari, Khalid S Alwadeai, James B Fink
BACKGROUND: Many in vitro models report higher inhaled dose with dry versus heated humidity. Heat-and-moisture exchangers (HMEs) provide passive humidity in ventilator-dependent patients but act as a barrier to aerosol. The HMEs designed to allow aerosol delivery (HME-ADs) have not been well described. The purpose of this study is to determine the impact on aerosol deposition of HME-ADs with and without active exhaled humidity in a simulated ventilator-dependent adult model. METHODS: We used an in vitro lung model consisting of an intubated teaching mannequin with an endotracheal tube of 8...
March 7, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28270126/analysis-of-novel-sjogren-s-syndrome-autoantibodies-in-patients-with-dry-eyes
#20
Sandra Everett, Sahana Vishwanath, Vanessa Cavero, Long Shen, Lakshmanan Suresh, Kishore Malyavantham, Norah Lincoff-Cohen, Julian L Ambrus
BACKGROUND: Dry eye is a common problem in Ophthalmology and may occur for many reasons including Sjogren's syndrome (SS). Recent studies have identified autoantibodies, anti-salivary gland protein 1 (SP1), anti-carbonic anhydrase 6 (CA6) and anti-parotid secretory protein (PSP), which occur early in the course of SS. The current studies were designed to evaluate how many patients with idiopathic dry eye and no evidence of systemic diseases from a dry eye practice have these autoantibodies...
March 7, 2017: BMC Ophthalmology
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