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https://www.readbyqxmd.com/read/29774840/widespread-treponema-pallidum-infection-in-nonhuman-primates-tanzania
#1
Idrissa S Chuma, Emmanuel K Batamuzi, D Anthony Collins, Robert D Fyumagwa, Luisa K Hallmaier-Wacker, Rudovick R Kazwala, Julius D Keyyu, Inyasi A Lejora, Iddi F Lipende, Simone Lüert, Filipa M D Paciência, Alexander Piel, Fiona A Stewart, Dietmar Zinner, Christian Roos, Sascha Knauf
We investigated Treponema pallidum infection in 8 nonhuman primate species (289 animals) in Tanzania during 2015-2017. We used a serologic treponemal test to detect antibodies against the bacterium. Infection was further confirmed from tissue samples of skin-ulcerated animals by 3 independent PCRs (polA, tp47, and TP_0619). Our findings indicate that T. pallidum infection is geographically widespread in Tanzania and occurs in several species (olive baboons, yellow baboons, vervet monkeys, and blue monkeys)...
June 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29774452/lymphedema-following-cancer-therapy-overview-and-options
#2
Michael Bernas, Saskia R J Thiadens, Betty Smoot, Jane M Armer, Paula Stewart, Jay Granzow
This summit focusing on lymphedema following cancer therapy was held during the 7th International Symposium on Cancer Metastasis through the Lymphovascular System. It was unique for the inclusion of patients with lymphedema joining physicians, therapists, healthcare professionals, and researchers to highlight what is known and more importantly what is unknown about the current state of research and treatment in the United States. The session opened with an introduction to lymphedema and then explored the incidence of multiple cancer-related lymphedemas, imaging tools and techniques useful for the diagnosis of lymphatic system abnormalities, and the new findings concerning the genetics of cancer-related lymphedema...
May 17, 2018: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/29773803/a-novel-small-molecule-chaperone-of-rod-opsin-and-its-potential-therapy-for-retinal-degeneration
#3
Yuanyuan Chen, Yu Chen, Beata Jastrzebska, Marcin Golczak, Sahil Gulati, Hong Tang, William Seibel, Xiaoyu Li, Hui Jin, Yong Han, Songqi Gao, Jianye Zhang, Xujie Liu, Hossein Heidari-Torkabadi, Phoebe L Stewart, William E Harte, Gregory P Tochtrop, Krzysztof Palczewski
Rhodopsin homeostasis is tightly coupled to rod photoreceptor cell survival and vision. Mutations resulting in the misfolding of rhodopsin can lead to autosomal dominant retinitis pigmentosa (adRP), a progressive retinal degeneration that currently is untreatable. Using a cell-based high-throughput screen (HTS) to identify small molecules that can stabilize the P23H-opsin mutant, which causes most cases of adRP, we identified a novel pharmacological chaperone of rod photoreceptor opsin, YC-001. As a non-retinoid molecule, YC-001 demonstrates micromolar potency and efficacy greater than 9-cis-retinal with lower cytotoxicity...
May 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29772230/replacing-c189-in-the-bzip-domain-of-zta-with-s-t-v-or-a-changes-dna-binding-specificity-to-four-types-of-double-stranded-dna
#4
Sreejana Ray, Desiree Tillo, Nima Assad, Aniekanabasi Ufot, Christopher Deppmann, Stewart R Durell, Aleksey Porollo, Charles Vinson
Zta is a bZIP transcription factor (TF) in the Epstein-Barr virus that binds unmethylated and methylated DNA sequences. Substitution of cysteine 189 of Zta to serine (Zta(C189S)) results in a virus that is unable to execute the lytic cycle which was attributed to a change in binding to methylated DNA sequences. To learn more about the role of this position in defining sequence-specific DNA binding, we mutated cysteine 189 to four other amino acids producing Zta(C189S), Zta(C189T), Zta(C189A), and Zta(C189V) mutants...
May 14, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29771896/how-simple-mistakes-and-short-term-bias-elevate-cardiovascular-risk
#5
EDITORIAL
Ralph Ah Stewart
No abstract text is available yet for this article.
May 18, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29771231/food-choice-motives-attitude-towards-and-intention-to-adopt-personalised-nutrition
#6
Audrey Rankin, Brendan P Bunting, Rui Poínhos, Ivo A van der Lans, Arnout Rh Fischer, Sharron Kuznesof, Mdv Almeida, Jerko Markovina, Lynn J Frewer, Barbara J Stewart-Knox
OBJECTIVE: The present study explored associations between food choice motives, attitudes towards and intention to adopt personalised nutrition, to inform communication strategies based on consumer priorities and concerns.Design/SettingA survey was administered online which included the Food Choice Questionnaire (FCQ) and items assessing attitudes towards and intention to adopt personalised nutrition. SUBJECTS: Nationally representative samples were recruited in nine EU countries (n 9381)...
May 17, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29770834/advances-in-drug-discovery-for-human-beta-cell-regeneration
#7
REVIEW
Esra Karakose, Courtney Ackeifi, Peng Wang, Andrew F Stewart
The numbers of insulin-secreting pancreatic beta cells are reduced in people with type 1 and type 2 diabetes. Driving beta cell regeneration in the pancreases of people with diabetes would be an attractive approach to reversing diabetes. While adult human beta cells have long been believed to be terminally differentiated and, therefore, irreversibly quiescent, it has become clear over recent years that this is not true. More specifically, both candidate and unbiased high-throughput screen approaches have revealed several classes of molecules that are clearly able to induce human beta cell proliferation...
May 16, 2018: Diabetologia
https://www.readbyqxmd.com/read/29770076/the-use-of-technology-to-improve-health-care-to-saskatchewan-s-first-nations-communities
#8
I Khan, N Ndubuka, K Stewart, V McKinney, I Mendez
Background: Saskatchewan is a province of over one million people and over 13% are Indigenous peoples, many of whom live on reserve lands. Despite continued efforts, access to health care remains a significant challenge for these Indigenous people, especially those in the North. Objective: To address this challenge, Saskatchewan's health care providers have been incorporating the use of technology for various health services. This paper describes various ways technology has been used in First Nations communities in Saskatchewan...
June 1, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29769641/erratum-braid-a-unifying-paradigm-for-the-analysis-of-combined-drug-action
#9
Nathaniel R Twarog, Elizabeth Stewart, Courtney Vowell Hammill, Anang A Shelat
This corrects the article DOI: 10.1038/srep25523.
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29768654/evidence-for-a-third-male-type-in-a-male-dimorphic-model-species
#10
Kathryn A Stewart, Tom P G Van den Beuken, Flor T Rhebergen, Jacques A Deere, Isabel M Smallegange
No abstract text is available yet for this article.
May 16, 2018: Ecology
https://www.readbyqxmd.com/read/29768092/are-only-infants-held-more-often-on-the-left-if-so-why-testing-the-attention-emotion-hypothesis-with-an-infant-a-vase-and-two-chimeric-tests-one-emotional-one-not
#11
Lauren Julius Harris, Rodrigo A Cárdenas, Nathaniel D Stewart, Jason B Almerigi
Most adults, especially women, hold infants and dolls but not books or packages on the left side. One reason may be that attention is more often leftward in response to infants, unlike emotionally neutral objects like books and packages. Women's stronger bias may reflect greater responsiveness to infants. Previously, we tested the attention hypothesis by comparing women's side-of-hold of a doll, book, and package with direction-of-attention on the Chimeric Faces Test (CFT) [Harris, L. J., Cárdenas, R. A...
May 16, 2018: Laterality
https://www.readbyqxmd.com/read/29768043/haptic-foot-pedal-influence-of-shoe-type-age-and-gender-on-subjective-pulse-perception
#12
Claudia Geitner, Stewart Birrell, Claudia Krehl, Paul Jennings
OBJECTIVE: This study investigates the influence of shoe type (sneakers and safety boots), age, and gender on the perception of haptic pulse feedback provided by a prototype accelerator pedal in a running stationary vehicle. BACKGROUND: Haptic feedback can be a less distracting alternative to traditionally visual and auditory in-vehicle feedback. However, to be effective, the device delivering the haptic feedback needs to be in contact with the person. Factors such as shoe type vary naturally over the season and could render feedback that is perceived well in one situation, unnoticeable in another...
June 2018: Human Factors
https://www.readbyqxmd.com/read/29767645/authors-response-to-letter-to-the-editor-by-allen-et-al-regarding-joint-statement-from-the-american-college-of-surgeons-committee-on-trauma-acs-cot-and-the-american-college-of-emergency-physicians-acep-regarding-the-clinical-use-of-resuscitative-endovascular
#13
Debra G Perina, Christopher S Kang, Eileen M Bulger, Ronald M Stewart, Robert J Winchell, Megan Brenner, Sharon Henry, Leonard J Weireter, Michael C Chang, Michael F Rotondo
No abstract text is available yet for this article.
2018: Trauma surgery & acute care open
https://www.readbyqxmd.com/read/29767643/response-to-letter-to-the-editor-from-dubose-and-colleagues-regarding-the-joint-statement-from-the-american-college-of-surgeons-committee-on-trauma-acs-cot-and-the-american-college-of-emergency-physicians-acep-regarding-the-clinical-use-of-resuscitative-endovascular
#14
Megan Brenner, Debra G Perina, Eileen M Bulger, Robert J Winchell, Christopher S Kang, Sharon Henry, Ronald M Stewart, Leonard J Weireter, Michael C Chang, Michael F Rotondo
No abstract text is available yet for this article.
2018: Trauma surgery & acute care open
https://www.readbyqxmd.com/read/29767548/disruption-of-chloroplast-function-through-downregulation-of-phytoene-desaturase-enhances-the-systemic-accumulation-of-an-aphid-borne-phloem-restricted-virus
#15
Stacy L DeBlasio, Ana Rita Rebelo, Katherine Parks, Stewart Gray, Michelle Cilia
Chloroplasts play a central role in pathogen defense in plants. However, the majority of studies explaining the relationship between pathogens and chloroplasts have focused on pathogens that infect mesophyll cells. In contrast, the family Luteoviridae comprises RNA viruses that replicate and traffic exclusively in the phloem. Recently, our lab has shown that Potato leafroll virus (PLRV), the type species in the genus Polerovirus, forms an extensive interaction network with chloroplast-localized proteins, which is partially dependent on the PLRV capsid readthrough domain (RTD)...
May 16, 2018: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/29766789/metabolomics-a-high-throughput-screen-for-biochemical-and-bioactivity-diversity-in-plants-and-crops
#16
Alexandre Foito, Derek Stewart
Plants and crops contain a staggering diversity of compounds, many of which have pharmacological activity towards a variety of diseases. These properties have been exploited by traditional and modern medicine providing important sources of healthcare to this day. The contribution of natural products (such as plant-derived) to the modern pharmacopeia is indeed significant; however, the process of identifying novel bioactive compounds from biological sources has been a central challenge in the discovery of natural products...
May 15, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29766622/evaluating-the-implementation-of-confusion-assessment-method-intensive-care-unit-using-a-quality-improvement-approach
#17
C Stewart, S Bench
Quality improvement (QI) is a way through which health care delivery can be made safer and more effective. Various models of quality improvement methods exist in health care today. These models can help guide and manage the process of introducing changes into clinical practice. The aim of this project was to implement the use of a delirium assessment tool into three adult critical care units within the same hospital using a QI approach. The objective was to improve the identification and management of delirium...
May 15, 2018: Nursing in Critical Care
https://www.readbyqxmd.com/read/29766419/biomonitoring-of-chlorpyrifos-exposure-and-health-risk-assessment-among-applicators-on-rice-farms-in-ghana
#18
Albert Atabila, Ross Sadler, Dung Tri Phung, Jonathan N Hogarh, Stewart Carswell, Scott Turner, Renu Patel, Des Connell, Cordia Chu
Chlorpyrifos is a neurotoxic insecticide that is widely used in the agricultural sector of Ghana. The main objective of this study was to evaluate the levels of chlorpyrifos exposure and health risk among applicators (n = 21) on irrigated rice farms in Ghana, based on a typical application event. Pre- and post-application urine samples (24-h) were collected from the applicators and analysed for 3,5,6-trichloro-2-pyridinol (TCP), using LC-MS/MS. The levels of chlorpyrifos-absorbed dose with the applicators were estimated from the urinary TCP levels...
May 15, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29766223/does-wildfire-open-a-policy-window-local-government-and-community-adaptation-after-fire-in-the-united-states
#19
Miranda H Mockrin, Hillary K Fishler, Susan I Stewart
Becoming a fire adapted community that can coexist with wildfire is envisioned as a continuous, iterative process of adaptation, but it is unclear how communities may pursue adaptation. Experience with wildfire and other natural hazards suggests that disasters may open a "window of opportunity" leading to local government policy changes. We examined how destructive wildfire affected progress toward becoming fire adapted in eight locations in the United States. We found that community-level adaptation following destructive fires is most common where destructive wildfire is novel and there is already government capacity and investment in wildfire regulation and land use planning...
May 15, 2018: Environmental Management
https://www.readbyqxmd.com/read/29766135/joint-statement-from-the-american-college-of-surgeons-committee-on-trauma-acs-cot-and-the-american-college-of-emergency-physicians-acep-regarding-the-clinical-use-of-resuscitative-endovascular-balloon-occlusion-of-the-aorta-reboa
#20
Megan Brenner, Eileen M Bulger, Debra G Perina, Sharon Henry, Christopher S Kang, Michael F Rotondo, Michael C Chang, Leonard J Weireter, Michael Coburn, Robert J Winchell, Ronald M Stewart
No abstract text is available yet for this article.
2018: Trauma surgery & acute care open
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