keyword
https://read.qxmd.com/read/38674056/understanding-functional-neurological-disorder-recent-insights-and-diagnostic-challenges
#1
REVIEW
Ioannis Mavroudis, Dimitrios Kazis, Fatima Zahra Kamal, Irina-Luciana Gurzu, Alin Ciobica, Manuela Pădurariu, Bogdan Novac, Alin Iordache
Functional neurological disorder (FND), formerly called conversion disorder, is a condition characterized by neurological symptoms that lack an identifiable organic purpose. These signs, which can consist of motor, sensory, or cognitive disturbances, are not deliberately produced and often vary in severity. Its diagnosis is predicated on clinical evaluation and the exclusion of other medical or psychiatric situations. Its treatment typically involves a multidisciplinary technique addressing each of the neurological symptoms and underlying psychological factors via a mixture of medical management, psychotherapy, and supportive interventions...
April 18, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38658293/how-stigma-unfolds-for-patients-with-functional-neurological-disorder
#2
JOURNAL ARTICLE
Caoimhe McLoughlin, Brodie McGhie-Fraser, Alan Carson, Tim Olde-Hartman, Jon Stone
OBJECTIVE: The aim of this study was to explore experiences of stigma in Functional Neurological Disorder (FND) from the perspective of the patient as it manifests from the onset of symptoms, up to diagnosis and subsequently. BACKGROUND: The existing literature clearly shows that stigma exists for many patients with FND, and is associated with poorer quality of life. However, it is less clear how stigma unfolds, and how it can be alleviated. METHODS: We performed a qualitative interview study with patients who were diagnosed with FND, using data based on semi-structured interviews...
April 16, 2024: Journal of Psychosomatic Research
https://read.qxmd.com/read/38645402/the-prevalence-of-hyperuricemia-and-the-association-between-hyperuricemia-and-age-in-patients-with-psychiatric-disorders-to-a-general-hospital-a-cross-section-study
#3
JOURNAL ARTICLE
Guodong Yang, Shuang Zhou, Yue Feng, Jiaran Lang, Yaxin Chen, Huipeng Ren
PURPOSE: In clinical work, it has been found that the prevalence of hyperuricemia (HUA) is significantly higher in younger patients with psychiatric disorders, but there are few studies in this area. The present study aims to evaluate the prevalence of HUA and the relationship between the HUA and age in hospitalized patients with psychiatric disorders in the real world, and to provide a theoretical basis for clinical staff to pay attention to the metabolic indicators of younger patients and for future related studies...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38643683/chronic-idiopathic-urinary-retention-comorbidity-and-outcome-in-102-individuals
#4
JOURNAL ARTICLE
Fintan Milligan, Charlotte Whittingham, Voula Granitsitotis, Helen Simpson, Julie Woodfield, Alan Carson, Jon Stone, Ingrid Hoeritzauer
OBJECTIVES: Chronic Idiopathic urinary retention is poorly understood. One small study suggests higher than expected rates of functional neurological disorder and pain comorbidity which may have implications for understanding the disorder. We investigated the frequency of functional neurological disorder, chronic pain other medical and psychiatric comorbidity, triggers of urinary retention, results of urodynamic assessment, medication history, management, and outcome in patients with chronic idiopathic urinary retention...
April 6, 2024: Journal of Psychosomatic Research
https://read.qxmd.com/read/38623749/personality-traits-related-to-cognitive-functioning-in-patients-with-functional-neurological-disorder
#5
JOURNAL ARTICLE
Lars de Vroege, Timothy L van Dijl, Jarinne E Woudstra-de Jong, Arjan C Videler, Willem J Kop
Cognitive symptoms are prevalent in patients with functional neurological disorder (FND). Several studies have suggested that personality traits such as neuroticism may play a pivotal role in the development of FND. FND has also been associated with alexithymia: patients with FND report difficulties in identifying, analyzing, and verbalizing emotions. Whether or not alexithymia and other personality traits are associated with cognitive symptomatology in patients with FND is unknown. In the current study, we explored whether the Big Five personality model factors (neuroticism, extraversion, openness, agreeableness, and conscientiousness) and alexithymia were associated with cognitive functioning in FND...
April 16, 2024: Journal of Clinical and Experimental Neuropsychology
https://read.qxmd.com/read/38615907/self-reported-anterograde-memory-loss-in-older-persons-that-is-not-validated-on-neuropsychological-assessment-considerations-for-a-dissociative-diagnosis
#6
JOURNAL ARTICLE
Philip Gerard Gasquoine
The past decade has witnessed amplified public awareness of age-related dementias. This has resulted in a dramatic rise in the number of older persons referred to memory clinics with a primary complaint of self-reported memory loss without an antecedent neurological event (e.g., stroke) who produce neuropsychological test profiles that lack evidence of such impairment. Since the latter part of the 19th century, a confusing array of changing terminology, criteria, and perceived causation have been ascribed to patients with unverified medical symptoms to implicate psychological causation...
April 14, 2024: Applied Neuropsychology. Adult
https://read.qxmd.com/read/38603918/psychological-flexibility-in-somatic-symptom-and-related-disorders-a-case-control-study
#7
JOURNAL ARTICLE
René J D M Selker, Tim Y Koppert, Jan H Houtveen, Rinie Geenen
A key diagnostic criterion of Somatic Symptom and related Disorders (SSD) comprises significant distress and excessive time-and-energy consuming thoughts, feelings, and behavior pertaining to somatic symptoms. This diagnostic criterion is lacking in central sensitivity syndromes (CSS), such as fibromyalgia, irritable bowel syndrome, and chronic fatigue syndrome. This strong emphasis on disturbed psychological processing of somatic symptoms, suggests that psychological flexibility is low in SDD. Psychological flexibility is defined as the ability to approach difficult or challenging internal states (thoughts, emotions, and bodily sensations) in a non-judgmental, mindful way, and being committed to pursue one's values...
May 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38584382/functional-neurological-disorders-challenging-the-mainstream-agnostic-causative-position
#8
JOURNAL ARTICLE
Anton Scamvougeras, David Castle
No abstract text is available yet for this article.
April 7, 2024: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://read.qxmd.com/read/38572274/primary-intramedullary-extradural-ewing-sarcoma
#9
Alameen Damer, Leslie Hamilton, Albert Tu, Donna L Johnston, Raveena Ramphal, Nagwa Wilson
Ewing sarcoma is the second most frequent primary bone tumour of childhood and adolescence. The aim of this report is to describe the imaging, pathology, clinical findings, and treatment of a primary intradural extramedullary Ewing sarcoma with a unique intracranial metastatic component in a pediatric patient. A 14-year-old girl with a history of mood disorders presented to the emergency department with a 3-week history of neck torticollis, cervical pain, paresis, and paresthesia of the upper and lower extremities on the left side...
June 2024: Radiology Case Reports
https://read.qxmd.com/read/38521891/social-cognition-in-parkinson-s-disease-and-functional-movement-disorders
#10
JOURNAL ARTICLE
Maria Caterina Silveri, Maria Rita Lo Monaco, Alice Tondinelli, Martina Petracca, Paola Zinzi, Serena Fragapane, Gino Pozzi, Francesco Pagnini, Anna Rita Bentivoglio, Sonia Di Tella
INTRODUCTION: Functional movement disorders (FMD) can overlap with Parkinson's disease (PD), and distinguishing between the two clinical conditions can be complex. Framing social cognition (theory of mind) (TOM) disorder, attention deficit, and psychodynamic features of FMD and PD may improve diagnosis. METHODS: Subjects with FMD and PD and healthy controls (HC) were administered tasks assessing TOM abilities and attention. The psychodynamic hypothesis of conversion disorder was explored by a questionnaire assessing dissociative symptoms...
March 23, 2024: Neurological Sciences
https://read.qxmd.com/read/38516259/posterior-cingulate-cortex-hyperactivity-in-conversion-disorder-a-pet-mri-study
#11
JOURNAL ARTICLE
Safiye Zeynep Tatlı, Mine Araz, Elgin Özkan, Elif Peker, Mehmetİlhan Erden, VesileŞentürk Cankorur
INTRODUCTION: Several neuroimaging studies have been conducted to demonstrate the specific structural and functional brain correlations of conversion disorder. Although the findings of neuroimaging studies are not consistent, when evaluated as a whole, they suggest the presence of significant brain abnormalities. The aim of this study is to investigate brain metabolic activity through F-18 fluorodeoxyglucose PET/MRI in order to shed light on the neural correlates of conversion disorder...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38515429/misdiagnosis-of-functional-neurological-symptom-disorders-in-paediatrics-narrative-review-and-relevant-case-report
#12
JOURNAL ARTICLE
Valentina Baglioni, Dario Esposito, Katerina Bernardi, Maria Novelli, Valerio Zaccaria, Serena Galosi, Francesco Pisani
Functional neurological symptom disorders (FNSD) pose a common challenge in clinical practice, particularly in pediatric cases where the clinical phenotypes can be intricate and easily confused with structural disturbances. The frequent coexistence of FNSDs with other medical disorders often results in misdiagnosis. In this review, we highlight the distinctions between FNSD and various psychiatric and neurological conditions. Contrary to the misconception that FNSD is a diagnosis of exclusion, we underscore its nature as a diagnosis of inclusion, contingent upon recognizing specific clinical features...
March 22, 2024: Clinical Child Psychology and Psychiatry
https://read.qxmd.com/read/38481748/the-differential-diagnosis-of-medical-and-psychogenic-disease-in-primary-care
#13
JOURNAL ARTICLE
Kosuke Ishizuka, Kiyoshi Shikino, Yu Li, Daiki Yokokawa, Tomoko Tsukamoto, Yasutaka Yanagita, Jumpei Kojima, Shiho Yamashita, Kazutaka Noda, Takanori Uehara, Masatomi Ikusaka
Diagnosis and management of psychogenic diseases such as conversion disorder, somatic symptom disorder (SSD), illness anxiety disorder, falsehood disorder, and psychotic disorder require an elaborate biopsychosocial approach and are often challenging. Herein, we propose the following points to differentiate medical diseases from these psychogenic diseases: correspondence between symptoms and objective findings or activities of daily living (ADL) impairment; placebo effect; clear provocative or palliative factors; progressive time course; paroxysmal or intermittent symptoms; unfamiliar but not strange expressions; symptoms worsen during sleep or rest...
March 2024: Journal of General and Family Medicine
https://read.qxmd.com/read/38481167/etiological-factors-and-symptom-triggers-in-functional-motor-symptoms-and-functional-seizures-a-pilot-investigation
#14
JOURNAL ARTICLE
L S Merritt Millman, Eleanor Short, Emily Ward, Biba Stanton, Abigail Bradley-Westguard, Laura H Goldstein, Joel S Winston, Mitul A Mehta, Timothy R Nicholson, Antje A T S Reinders, Anthony S David, Mark J Edwards, Trudie Chalder, Matthew Hotopf, Susannah Pick
OBJECTIVE: This study examined etiological factors and symptom triggers of functional motor symptoms (FMS) or functional seizures (FS) and assessed potential relationships with relevant clinical features (i.e., functional symptoms, quality of life, and general functioning). METHODS: Seventeen participants with FMS or FS and 17 healthy control participants underwent an in-depth clinical interview and completed questionnaires assessing adverse life events, psychological and physical symptoms, alexithymia, autistic traits, illness perceptions, health-related quality of life (HRQoL), and work and social functioning...
March 14, 2024: Journal of Neuropsychiatry and Clinical Neurosciences
https://read.qxmd.com/read/38458028/anger-regulation-in-patients-with-functional-neurological-disorder-a-systematic-review
#15
REVIEW
T L van Dijl, A C Videler, H P Aben, W J Kop
BACKGROUND: Functional neurological disorder (FND) has been associated with predisposing psychological factors, including dysregulation of anger-related processes. This paper provides a systematic review of the literature on anger regulation in FND. We evaluated anger-related research on patient self-report, observational, and laboratory based measures in FND. The review also addresses adverse childhood experiences and their relation with anger regulation, and the effects of therapies targeting anger regulation in FND...
March 2, 2024: General Hospital Psychiatry
https://read.qxmd.com/read/38422831/transient-resting-state-salience-limbic-co-activation-patterns-in-functional-neurological-disorders
#16
JOURNAL ARTICLE
Samantha Weber, Janine Bühler, Serafeim Loukas, Thomas A W Bolton, Giorgio Vanini, Rupert Bruckmaier, Selma Aybek
BACKGROUND: Functional neurological disorders were historically regarded as the manifestation of a dynamic brain lesion which might be linked to trauma or stress, although this association has not yet been directly tested yet. Analysing large-scale brain network dynamics at rest in relation to stress biomarkers assessed by salivary cortisol and amylase could provide new insights into the pathophysiology of functional neurological symptoms. METHODS: Case-control resting-state functional magnetic resonance imaging study of 79 patients with mixed functional neurological disorders (i...
February 28, 2024: NeuroImage: Clinical
https://read.qxmd.com/read/38382188/illness-representations-of-people-with-later-onset-functional-seizures
#17
JOURNAL ARTICLE
I A Williams, P G Morris, K Forristal, J Stone, D C Gillespie
PURPOSE: Although functional seizures can start at any age, little is known about the individuals for whom onset occurs after the age of 40. It has been proposed that health-related traumatic events are more relevant causal factors for people with 'later-onset functional seizures' than for those whose functional seizures begin earlier in life, however, the illness representations of people with later-onset functional seizures have not yet been investigated. This study aimed to understand the experiences and illness representations of people with later-onset functional seizures...
February 20, 2024: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/38361967/non-invasive-neuromodulation-of-the-right-temporoparietal-junction-using-theta-burst-stimulation-in-functional-neurological-disorder
#18
JOURNAL ARTICLE
Janine Bühler, Samantha Weber, Serafeim Loukas, Sebastian Walther, Selma Aybek
BACKGROUND: Disrupted sense of agency (SoA)-the sense of being the agent of one's own actions-has been demonstrated in patients with functional neurological disorder (FND), and a key area of the corresponding neuronal network is the right temporoparietal junction (rTPJ). Several functional MRI (fMRI) studies have found hypoactivation as well as hyperactivation of the rTPJ in FND. In a proof-of-concept study, we tested whether repetitive transcranial magnetic stimulation (rTMS) over the rTPJ could restore this aberrant activity...
2024: BMJ neurology open
https://read.qxmd.com/read/38361492/sun-pain-and-solar-dysesthesia-a-new-challenge-in-clinical-practice
#19
REVIEW
Piergiacomo Calzavara-Pinton, Francesco Tonon, Irene Calzavara-Pinton
BACKGROUND: A few patients report intense pain and other unpleasant sensations, such as burning, dysesthesia and hyperalgesia, after even brief exposure to the sun and in the absence of any skin lesion. Sometimes they also develop systemic symptoms, such as mild fever, fatigue, faintness and fainting. As a result, these patients carefully avoid even short-term sun exposure with a consequent severe negative impact on their lives. METHODS: We have reviewed the clinical findings and the results of photobiological investigations of 10 patients who presented this clinical picture...
March 2024: Photodermatology, Photoimmunology & Photomedicine
https://read.qxmd.com/read/38359638/forearm-bisection-task-suggests-an-alteration-in-body-schema-in-patients-with-functional-movement-disorders-motor-conversion-disorders
#20
JOURNAL ARTICLE
Veronica Nisticò, Neofytos Ilia, Francesca Conte, Giovanni Broglia, Claudio Sanguineti, Francesco Lombardi, Silvia Scaravaggi, Laura Mangiaterra, Roberta Tedesco, Orsola Gambini, Alberto Priori, Angelo Maravita, Benedetta Demartini
OBJECTIVES: To explore potential alterations of the Body Schema, the implicit sensorimotor representation of one's own body, in patients with Functional Movement Disorders (FMD, Motor Conversion Disorders), characterized by neurological symptoms of altered voluntary motor function that cannot be explained by typical medical conditions. This investigation is prompted by the potential dissociation from their reportedly intact sense of ownership. METHODS: 10 FMD patients and 11 healthy controls (HC) underwent the Forearm Bisection Task, aimed at assessing perceived body metrics, which consists in asking the subject, blindfolded, to repeatedly point at the perceived middle point of their dominant forearm with the index finger of their contralateral hand, and a psychometric assessment for anxiety, depression, alexithymia, and tendency to dissociation...
February 13, 2024: Journal of Psychosomatic Research
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