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pulmonary nodule diagnosis

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https://www.readbyqxmd.com/read/28214126/pulmonary-nodules-in-african-migrants-caused-by-chronic-schistosomiasis
#1
REVIEW
Federico Gobbi, Dora Buonfrate, Andrea Angheben, Anna Beltrame, Matteo Bassetti, Luca Bertolaccini, Giuseppe Bogina, Simone Caia, Silvia Duranti, Maria Gobbo, Valentina Marchese, Stefania Marocco, Maria Merelli, Geraldo Monteiro, Alberto Terzi, Zeno Bisoffi
Schistosomiasis is a neglected tropical disease that can cause mainly hepatic and genitourinary damage, depending on the species. Involvement of the lungs has been commonly described in acute infection (Katayama syndrome) and chronic infection (pulmonary hypertension). Although rarely reported in the scientific literature, cases of lung nodules due to chronic schistosome infection are also possible and are probably more frequent than commonly thought. Here we report seven cases of African migrants who were diagnosed with chronic schistosomiasis and pulmonary nodules due to deposition of schistosome eggs, and we compare our findings to the case reports found in the scientific literature...
February 14, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28203428/multiple-cavitating-pulmonary-nodules-rare-manifestation-of-benign-metastatic-leiomyoma
#2
Sa Ra Lee, Youn-I Choi, Seok Jeong Lee, Sung Shine Shim, Jin Hwa Lee, Yoo Kyung Kim, Soon Hee Sung
Benign metastasizing leiomyoma (BML) is a rare disease of pathologically benign, but the tumor metastasizes to other organs. The most common organ involved in BML is lung. Pulmonary involvement usually manifested as multiple nodules on chest X-ray, however we experienced an interesting case of a 52-year-old premenopausal woman who presented with multiple bilateral lung cavitations and nodules on a chest X-ray without any respiratory symptoms. Chest computed-tomography identified multiple cavitary lesions of 5-12 mm in diameter and well-defined nodules of 5-10 mm in diameter in both lung fields...
January 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28202941/risk-of-pleural-recurrence-in-early-stage-lung-cancer-patients-after-percutaneous-transthoracic-needle-biopsy-a-meta-analysis
#3
Ting Wang, Lili Luo, Qinghua Zhou
Percutaneous transthoracic needle biopsies (PTNB) are widely used for the diagnosis of a peripheral pulmonary nodules, but the risk of pleural recurrence in lung cancer patients remains undetermined. Our meta-analysis aims to answer the question whether PTNB strategy increases the risk of recurrence. PubMed, EMBASE, The Cochrane Library, and China National Knowledge Infrastructure (CNKI) were searched from inception to January 9, 2016. A total of 1242 patients from 5 studies were included. The results showed that PTNB does not increase risk of total recurrence (Odds Ratio,0...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28194087/occupational-bronchiolitis-induced-by-cotton-dust-exposure-in-a-nonsmoker
#4
Richa Mittal, Pawan Gupta, Sunil K Chhabra
The most well-known disease caused by cotton dust is byssinosis though it is also associated with chronic obstructive airways disease, and very rarely, interstitial lung disease. Obliterative bronchiolitis has never been reported in this setting. We report a 63-year-old, nonsmoker male, who presented with complaints of cough and exertional dyspnoea for 10 years. He had worked in textile industry for 35 years and symptoms had persisted even after quitting. Examination revealed prolonged expiration with expiratory wheeze, and pulmonary function tests revealed severe airflow limitation with air trapping and impaired diffusion capacity...
May 2016: Indian Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28183501/an-unusual-cause-of-pulmonary-nodules-after-stem-cell-transplantation
#5
Anna K Brady, Jonathan R Fromm, Siddhartha G Kapnadak
A man in his 20s with a history of classical Hodgkin's lymphoma was admitted with fever. His original lymphoma diagnosis was made 3 years prior, when he had presented with lymphadenopathy and a mediastinal mass. He had relapsed disease despite chemotherapy and radiation. As a result, he underwent autologous peripheral blood stem cell transplant (SCT) 6 months prior to current presentation and subsequently allogeneic SCT 2 months prior for added graft vs tumor effect.
February 2017: Chest
https://www.readbyqxmd.com/read/28182861/diffuse-pulmonary-ossification-in-fibrosing-interstitial-lung-diseases-prevalence-and-associations
#6
Ryoko Egashira, Joseph Jacob, Maria A Kokosi, Anne-Laure Brun, Alexandra Rice, Andrew G Nicholson, Athol U Wells, David M Hansell
Purpose To investigate the prevalence of diffuse pulmonary ossification (DPO) in patients with fibrosing interstitial lung disease (ILD) and determine whether there are differences among the types of ILDs. Materials and Methods Institutional review board approval was given and patient consent was not required for this study. The study population comprised 892 consecutive patients with fibrosing ILD, including 456 patients with idiopathic pulmonary fibrosis (IPF) (men, 366; women, 90; median age, 72 years [range, 38-93 years]), 244 with nonspecific interstitial pneumonia (men, 79; women, 165; median age, 60...
February 9, 2017: Radiology
https://www.readbyqxmd.com/read/28182730/68ga-dotatate-pet-ct-imaging-of-indeterminate-pulmonary-nodules-and-lung-cancer
#7
Ronald Walker, Stephen Deppen, Gary Smith, Chanjuan Shi, Jonathan Lehman, Jeff Clanton, Brandon Moore, Rena Burns, Eric L Grogan, Pierre P Massion
PURPOSE: 18F-FDG PET/CT is widely used to evaluate indeterminate pulmonary nodules (IPNs). False positive results occur, especially from active granulomatous nodules. A PET-based imaging agent with superior specificity to 18F-FDG for IPNs, is badly needed, especially in areas of endemic granulomatous nodules. Somatostatin receptors (SSTR) are expressed in many malignant cells including small cell and non-small cell lung cancers (NSCLCs). 68Ga-DOTATATE, a positron emitter labeled somatostatin analog, combined with PET/CT imaging, may improve the diagnosis of IPNs over 18F-FDG by reducing false positives...
2017: PloS One
https://www.readbyqxmd.com/read/28177201/factors-associated-with-the-diagnostic-yield-of-computed-tomography-guided-transbronchial-lung-biopsy
#8
Seon Cheol Park, Cheong Ju Kim, Chang Hoon Han, Sun Min Lee
BACKGROUND: Computed tomography (CT) may be useful for increasing the diagnostic yield of transbronchial lung biopsy (TBLB). However, only a few studies with small sample sizes have reported the diagnostic utility of CT-guided TBLB and the factors affecting the diagnostic accuracy of CT-guided TBLB are not well known. We evaluated the diagnostic yield of CT-guided TBLB and associated factors. METHODS: CT-guided TBLB was performed in 59 patients. Both conventional fluoroscopy and CT were used in all patients for TBLB...
February 8, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28144062/role-of-radial-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-in-the-diagnosis-of-pulmonary-nodules-case-report-and-literature-review
#9
Sahajal Dhooria, Inderpaul Singh Sehgal, Nalini Gupta, Ashutosh Nath Aggarwal, Digambar Behera, Ritesh Agarwal
The diagnosis of pulmonary nodules can be made using several methods including computed tomography (CT)-guided fine-needle aspiration (FNA), radial endobronchial ultrasound (EBUS)-guided sampling techniques (transbronchial lung biopsy [TBLB], transbronchial brush, bronchoalveolar lavage, or transbronchial needle aspiration [TBNA]), or occasionally with convex probe (CP) EBUS-TBNA. While CT-guided FNA is associated with a high (25%) rate of pneumothorax, the CP-EBUS cannot reach lesions beyond the interlobar region...
January 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28133244/-a-case-of-minimal-thyroid-carcinoma-diagnosed-by-a-solitary-pulmonary-metastasis
#10
Hiroshi Kawai, Ryoma Sugimoto, Norichika Iga, Hirokuni Ikeda, Ryosuke Yoshida, Naohisa Waki, Masahiro Ishizaki, Hideyuki Nishi, Kazuki Yamashita
We report a case of minimal thyroid carcinoma diagnosed by a solitary pulmonary metastasis. A 70's man visited a medical practitioner because of chest discomfort, and there was an abnormality on the chest X-ray. Chest computed tomography(CT) showed a nodule in the right middle lobe of the lung. Positron emission tomography with 18-fluorodeoxyglucose(FDG)-PET revealed increased FDG uptake in that tumor, but did not reveal any other lesion. The tumor was clinically suspected to be a carcinoid tumor, primary lung cancer, metastatic lung cancer, or a benign tumor...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28131426/preoperative-localization-of-lung-nodules-with-fiducial-markers-feasibility-and-technical-considerations
#11
Amita Sharma, Shaunagh McDermott, Douglas J Mathisen, Jo-Anne O Shepard
BACKGROUND: The purpose of this study was to determine whether computed tomography-guided fiducial placement is a feasible and safe localization procedure to aid resection of small pulmonary nodules. METHODS: A retrospective review was performed of 20 nodules (mean size 11 mm; range, 6 to 19 mm) referred for preoperative computed tomography-guided fiducial placement in 19 patients (average age 64 ± 11 years; 13 women and 6 men). RESULTS: The technical success rate for the placement of fiducials was 95%, with deployment of fiducials into the pleural space in 1 case...
January 25, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28127434/pulmonary-cryptococcosis-mimicking-a-metastasis-in-a-patient-with-ewing-sarcoma
#12
Akio Sakamoto, Masanori Hisaoka
Cryptococcosis is an invasive fungal infection that is common in immunocompromised patients. A 22-year-old woman with Ewing sarcoma in the right proximal humerus was treated by resection and chemotherapy. Computed tomography detected a small nodule in her right upper pulmonary lobe after completion of her chemotherapy. With the presumptive diagnosis of pulmonary metastasis, she underwent resection. Evaluation of the resected specimen revealed pulmonary cryptococcosis, and the patient was treated with oral fluconazole for 18 weeks...
September 2016: Respirology Case Reports
https://www.readbyqxmd.com/read/28126538/rethinking-autoantibody-signature-panels-for-cancer-diagnosis-a-brief-report
#13
Michael J Campa, Elizabeth B Gottlin, James E Herndon, Edward F Patz
INTRODUCTION: Most pulmonary nodules found on imaging studies are indeterminate, but because of the concern for lung cancer, all patients require further evaluation with resultant radiation risk, significant cost and delays in diagnosis. We hypothesized that a diagnostic blood test based on detection of autoantibodies against cancer antigens would be able to distinguish a benign nodule from lung cancer. METHODS: We identified a panel of 25 serum autoantibodies associated with NSCLC and constructed a protein microarray containing the autoantigens...
January 23, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28116091/pulmonary-benign-metastasizing-leiomyoma-presented-as-acute-respiratory-distress
#14
Jean Pastré, Karine Juvin, Bertrand Grand, Laure Gibault, Judith Valcke, Dominique Israël-Biet
Benign metastasizing leiomyoma (BML) is a very rare condition and is characterized by the presence of benign smooth muscle tumours in organs distant from the uterus, most commonly the lung. It generally affects women of reproductive age and prognostic is usually excellent. However, the course of the disease is unpredictable. We report here the case of a 76-year-old woman with a previous medical history of uterine benign leiomyomas in whom BML was acutely revealed by a respiratory distress due to voluminous pulmonary and pleural leiomyomas requiring surgical extraction...
March 2017: Respirology Case Reports
https://www.readbyqxmd.com/read/28115167/physician-assessment-of-pre-test-probability-of-malignancy-and-adherence-with-guidelines-for-pulmonary-nodule-evaluation
#15
Nichole T Tanner, Alexander Porter, Michael Gould, Xiao-Jun Li, Anil Vachani, Gerard A Silvestri
BACKGROUND: The annual incidence of pulmonary nodules is estimated at 1.57 million. Guidelines recommend utilizing an initial assessment of nodule probability for malignancy (pCA). A previous study found that despite this recommendation, physicians did not follow guidelines. METHODS: Physician (n= 337) and two previously validated risk model assessment of cancer pre-test probability were evaluated for performance in 337 patients with pulmonary nodules based on final diagnosis and compared...
January 20, 2017: Chest
https://www.readbyqxmd.com/read/28115008/hereditary-hemorrhagic-telangiectasia-liver-disease-and-elevated-serum-testosterone-osler-weber-rendu-syndrome-a-case-report
#16
R Dissanayake, K P K Y M D S Wickramarathne, S N Seneviratne, S N Perera, M U J Fernando, V P Wickramasinghe
BACKGROUND: A Sri Lankan girl with hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome) is described. CASE PRESENTATION: She presented with recurrent spontaneous epistaxis, pulmonary arterio venous malformation and oral telangiectasia. A diagnosis of Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome) was made based on the presence of three Curacao criteria (out of four). Evaluations of her jaundice revealed chronic parenchymal liver disease with multiple nodules in the liver with early portal hypertension...
January 23, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28113928/automatic-scoring-of-multiple-semantic-attributes-with-multi-task-feature-leverage-a-study-on-pulmonary-nodules-in-ct-images
#17
Sihong Chen, Jing Qin, Xing Ji, Baiying Lei, Tianfu Wang, Dong Ni, Jie-Zhi Cheng
The gap between the computational and semantic features is the one of major factors that bottlenecks the computer-aided diagnosis (CAD) performance from clinical usage. To bridge this gap, we exploit three multi-task learning (MTL) schemes to leverage heterogeneous computational features derived from deep learning models of stacked denoising autoencoder (SDAE) and convolutional neural network (CNN), as well as hand-crafted Haar-like and HoG features, for the description of 9 semantic features for lung nodules in CT images...
November 16, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28113302/multi-level-contextual-3d-cnns-for-false-positive-reduction-in-pulmonary-nodule-detection
#18
Qi Dou, Hao Chen, Lequan Yu, Jing Qin, Pheng Ann Heng
OBJECTIVE: False positive reduction is one of the most crucial components in an automated pulmonary nodule detection system, which plays an important role in lung cancer diagnosis and early treatment. The objective of this paper is to effectively address the challenges in this task and therefore to accurately discriminate the true nodules from a large number of candidates. METHODS: We propose a novel method employing 3D convolutional neural networks (CNNs) for false positive reduction in automated pulmonary nodule detection from volumetric CT scans...
September 26, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28105096/nocardiosis-in-ectopic-acth-syndrome-a-case-report-and-review-of-11-cases-from-the-literature
#19
Lichen Xu, Qiaomai Xu, Meifang Yang, Hainv Gao, Mingzhi Xu, Weihang Ma
Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) associated with nocardiosis is rare, and little information is available regarding its clinical characteristics. In this study, the case of a 35-year-old male patient who showed significant cushingoid features and had a cough with yellow phlegm for 1 month is described. Pulmonary computed tomography (CT) scanning and (18)F-fluorodeoxyglucose positron emission tomography combined with CT identified two different lesions in the mediastinum and pulmonary region, respectively...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28104952/pitfalls-in-interpretation-of-fdg-pet-ct-septic-pulmonary-emboli-mimicking-metastases-in-a-case-of-gastric-carcinoma
#20
Harkirat Singh, Aftab Alam, T V S V G K Tilak, Prateek Kinra, Brijesh K Soni
Inflammatory lesions may sometimes show intense tracer uptake and mimic neoplastic lesions on (18) F-fluoro-deoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT). We report one such false positive case on FDG PET/CT, where septic pulmonary emboli (SPE) mimicked pulmonary metastases. A 45-year-old man with stomach cancer had an indwelling central venous catheter (CVC) in situ while on neoadjuvant chemotherapy. He underwent FDG PET/CT scan for response assessment and the images revealed multiple, intensely FDG avid, peripheral, lung nodules with feeding vessels, which were suspicious for pulmonary metastases...
October 2016: Indian Journal of Radiology & Imaging
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