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pulmonary nodule diagnosis

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https://www.readbyqxmd.com/read/29334967/risk-factors-and-treatment-of-pneumothorax-secondary-to-granulomatosis-with-polyangiitis-a-clinical-analysis-of-25-cases
#1
REVIEW
Xuhua Shi, Yongfeng Zhang, Yuewu Lu
OBJECTIVES: To investigate the risk factors and treatment strategies for pneumothorax secondary to granulomatosis with polyangiitis (GPA). METHOD: Retrospective analysis of cases with pneumothorax secondary to GPA from our own practice and published on literature. RESULTS: A total of 25 patients, 18 males and 7 females, mean age 44 ± 15.7 years, were analyzed. Diagnosis included pneumothorax (11 cases), hydropneumothorax (n = 5), empyema (n = 8) and hemopneumothorax (n = 1)...
January 15, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29322720/invasive-aspergillus-pseudomembranous-and-obstructive-tracheo-bronchitis-in-an-immuno-competent-patient
#2
Ramesh S Pal, Sonam Spalgais, Amit Kumar Murar, Umesh Chandra Ojha
A 19 year female, presented with life threatening haemoptysis and cough with minimum expectoration for 3 months. Bronchoscopy showed multiple nodules in airway. The direct microscopy and culture of sputum revealed fungal elements and Aspergillus flavus respectively. Serum Galactomannan was positive. Thus diagnosis of invasive aspergillus tracheo-bronchitis made. She responded to voriconazole. Aspergillus tracheo-bronchitis is a rare form of invasive pulmonary aspergillosis in immuno-competent host. Aspergillus spp in respiratory samples should not be routinely discarded as colonization...
November 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29320833/-analysis-of-9-cases-of-nodular-type-of-pulmonary-cryptococcosis-with-coexisting-lung-cancer-confirmed-by-pathological-examinations
#3
H Y Li, C Q Lan, H Weng, S X Chen, Q H Lin, J B Huang
Objective: To describe the characteristics of the nodular type of pulmonary cryptococcosis (PC) with coexisting lung cancer. Methods: A total of 9 cases of PC with coexisting lung cancer, admitted to Fuzhou Pulmonary Hospital of Fujian from 1st January 2009 to 31th December 2016, and confirmed by pathological examinations, were studied and the related literature were reviewed. Results: The patients consisted of 1 male and 8 females, with a mean age of (53±10) years (range, 38 to 68 years). Four patients (44...
November 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29312770/development-of-pulmonary-langerhans-cell-histiocytosis-in-a-patient-with-established-adenocarcinoma-of-the-lung
#4
Or Kalchiem-Dekel, Adina Paulk, Seth J Kligerman, Allen P Burke, Nirav G Shah, Renee K Dixon
Newly-appearing lung nodules on surveillance imaging in patients with pre-existing lung cancer can present a diagnostic dilemma when attempting to differentiate between metastatic disease, infection, and other inflammatory conditions. Here we report a case of an EGFR-/ALK-/BRAF+ metastatic adenocarcinoma patient who underwent lung biopsy for evaluation of upper-lobe predominant lung nodules revealed to represent pulmonary Langerhans cell histiocytosis (PLCH). The patient was a heavy smoker and admitted to increase her smoking habit after initially learning about her diagnosis with lung cancer...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29311420/computer-aided-diagnosis-of-lung-cancer-the-effect-of-training-datasets-on-classification-accuracy-of-lung-nodules
#5
Jing Gong, Ji-Yu Liu, Xi-Wen Sun, Bin Zheng, Sheng-Dong Nie
This study aims to develop a computer-aided diagnosis (CADx) scheme for classification between malignant and benign lung nodules, and also assess whether CADx performance changes in detecting nodules associated with early and advanced stage lung cancer. Methods: The study involves 243 biopsy-confirmed pulmonary nodules. Among them, 76 are benign, 81 are stage I and 86 are stage III malignant nodules. Cases are partitioned into 3 datasets involving: (1) all nodules, (2) benign and stage I malignant nodules, and (3) benign and stage III malignant nodules...
January 9, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29304756/medical-treatment-of-an%C3%A2-unusual-cerebral-hydatid-disease
#6
Shu Chen, Ning Li, Feifei Yang, Jiqin Wu, Yuekai Hu, Shenglei Yu, Qi Chen, Xuan Wang, Xinyu Wang, Yuanyuan Liu, Jianming Zheng
BACKGROUND: Hydatid disease is a worldwide zoonosis produced by the larval stage of cestodes of the Echinococcus genus. Hydatid disease primarily involves the liver and lungs. The brain is involved in less than 2% of cases. Surgery has long been the only choice for the treatment, but chemotherapy has been successfully replaced surgery in some special cases. CASE PRESENTATION: We report a rare hydatid disease case which presented with multiple lesions in right frontal lobe, an uncommon site, and in the liver and lungs...
January 5, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29299093/systemic-air-embolism-after-percutaneous-lung-biopsy-a-manageable-complication
#7
Lucas Fiore, Nathan Elie Frenk, Guilherme Lopes Pinheiro Martins, Publio Cesar Cavalcante Viana, Marcos Roberto de Menezes
CT-guided percutaneous biopsy is a resourceful and widely used tool to evaluate pulmonary nodules that frequently avoids costly and unnecessary surgeries. Severe complications occur in less than 1% of cases and include gas embolism, which is rarely documented. We report a case of gas embolism after transthoracic biopsies and discuss the pathophysiology and the benefits of early diagnosis and proper management.
June 2017: Journal of Radiology Case Reports
https://www.readbyqxmd.com/read/29296228/ct-guided-hookwire-localization-before-video-assisted-thoracoscopic-surgery-for-solitary-ground-glass-opacity-dominant-pulmonary-nodules-radiologic-pathologic-analysis
#8
Hao-Zhe Huang, Guang-Zhi Wang, Li-Chao Xu, Guo-Dong Li, Ying Wang, Yao-Hui Wang, Xin-Hong He, Wen-Tao Li
The optimal screening or treatment strategies of solitary pulmonary nodules especially ground-glass opacities (GGOs) remain controversial. With CT-guided Hookwire localization, it is accurate to find the small lesions during video-assisted thoracoscopic surgery (VATS). In this study, we evaluate the efficiency and safety of CT-guided Hookwire localization of GGO-dominant (GGO component > 50%) pulmonary nodules before VATS and investigate the correlation between the radiologic features and pathology. From April 2008 to April 2014, a total of 273 patients with solitary GGO-dominant pulmonary nodules were included...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29290809/near-infrared-intraoperative-imaging-of-thoracic-sympathetic-nerves-from-preclinical-study-to-clinical-trial
#9
Kunshan He, Jian Zhou, Fan Yang, Chongwei Chi, Hao Li, Yamin Mao, Bengang Hui, Kun Wang, Jie Tian, Jun Wang
The sympathetic nervous system controls and regulates the activities of the heart and other organs. Sympathetic nervous system dysfunction leads to disease. Therefore, intraoperative real-time imaging of thoracic sympathetic nerves (ITSN) would be of great clinical significance for diagnosis and therapy. The aim of this experimental study was to evaluate the feasibility and validity of intraoperative ITSN using indocyanine green (ICG). METHODS: ITSN using ICG was performed on 10 rabbits to determine its feasibility...
2018: Theranostics
https://www.readbyqxmd.com/read/29282351/marked-18-fuorine-fluorodeoxyglucose-fdg-avidity-of-an-intrapulmonary-typical-carcinoid-tumor-manifesting-as-a-bronchocele-in-an-asymptomatic-middle-aged-woman
#10
Camila Saadé-Yordán, Edward McBurney-Henriquez, Ricardo González-Santoni, Carmen Gurrea-Rosas, José Montalvo-Fitzpatrick, José A Maldonado-Vargas
BACKGROUND Intrapulmonary carcinoid tumors (ICTs) are malignant, slow-growing tumors classified as either: i) typical, less aggressive, well-differentiated tumors or ii) atypical, more aggressive, poorly-differentiated tumors. Most typical carcinoid tumors originate in the central airway and present with symptoms related to bronchial obstruction. In contrast, atypical carcinoids tend to occur more peripherally and are generally detected incidentally as a solitary pulmonary nodule (SPN). Typical carcinoid tumors usually do not exhibit increased metabolic activity on positron emission tomography with 18-fuorine-fluorodeoxyglucose (FDG PET) as would be expected for malignant tumors...
December 28, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29279481/lupus-pleuritis-with-silicotic-nodules-in-the-parietal-pleura
#11
Kazuo Tsuchiya, Mikio Toyoshima, Atsuki Fukada, Daisuke Akahori, Kazuhito Funai, Takafumi Suda
A 63-year-old man with occupational exposure to silica presented with cutaneous ulcer, pleuritic pain, and a fever. Laboratory data showed lymphopenia and positive serum antinuclear and anti-DNA antibodies. Computed tomography of the chest showed egg shell-like calcification of the hilar and mediastinal lymph nodes without pulmonary parenchymal involvement of silicosis. A surgical biopsy showed silicotic nodules with surrounding infiltration of lymphocytes and plasma cells in the parietal pleura. With a diagnosis of systemic lupus erythematosus (SLE), systemic corticosteroid therapy was given, which led to the resolution of symptoms and laboratory abnormalities...
December 27, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29261826/communication-about-the-probability-of-cancer-in-indeterminate-pulmonary-nodules
#12
Amelia W Maiga, Stephen A Deppen, Pierre P Massion, Carol Callaway-Lane, Rhonda Pinkerman, Robert S Dittus, Eric S Lambright, Jonathan C Nesbitt, Eric L Grogan
Importance: Clinical guidelines recommend that clinicians estimate the probability of malignancy for patients with indeterminate pulmonary nodules (IPNs) larger than 8 mm. Adherence to these guidelines is unknown. Objectives: To determine whether clinicians document the probability of malignancy in high-risk IPNs and to compare these quantitative or qualitative predictions with the validated Mayo Clinic Model. Design, Setting, and Participants: Single-institution, retrospective cohort study of patients from a tertiary care Department of Veterans Affairs hospital from January 1, 2003, through December 31, 2015...
December 20, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29251406/response-evaluation-criteria-in-solid-tumors-recist-following-neoadjuvant-chemotherapy-in-osteosarcoma
#13
Lillian M Guenther, R Grant Rowe, Patricia T Acharya, David W Swenson, Stephanie C Meyer, Catherine M Clinton, Dongjing Guo, Madhumitha Sridharan, Wendy B London, Holcombe E Grier, Kirsten Ecklund, Katherine A Janeway
BACKGROUND: In osteosarcoma, patient survival has not changed in over 30 years. Multiple phase II trials have been conducted in osteosarcoma using the Response Evaluation Criteria in Solid Tumors (RECIST) as a primary endpoint; however, none of these have revealed new treatment strategies. We investigated RECIST in newly diagnosed patients who received neoadjuvant chemotherapy proven to be beneficial. METHODS: Patients treated from 1986 to 2011 for newly diagnosed osteosarcoma with paired tumor imaging before and after adequate neoadjuvant chemotherapy were included in this retrospective study...
December 18, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29245323/lung-adenocarcinoma-and-pulmonary-metastases-coexist-in-a-patient-with-papillary-thyroid-carcinoma-a-case-report
#14
Changhai Cheng, Jinxin Zhou, Xiaonan Shao
RATIONALE: Multiple primary malignant tumors (MPMTs) are defined as 2 or more independent primary malignancies of different histologies/origins in the same individual. Although the incidence of MPMTs is being increasing, second primary cancer (SPC) is still rare and difficult to distinguish from metastasis. Here, we present a case of thyroid carcinoma with lung metastasis and primary lung cancer. PATIENTS CONCERNS: The patient was a 66-year-old man diagnosed of papillary thyroid carcinoma (PTC) with lymph nodes, lung, and skeletons metastases...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29245295/lymphangiomatosis-involving-the-pulmonary-and-extrapulmonary-lymph-nodes-and-surrounding-soft-tissue-a-rare-case-report
#15
Xuhua Fang, Ziling Huang, Yu Zeng, Xuyou Zhu, Siqi Wang, Xiaoting Yu, Xian Li, Chunyan Wu, Xianghua Yi
BACKGROUND: Diffuse pulmonary lymphangiomatosis (DPL) mainly affects the lung and pleura. There are very few pathological reports of lung damage accompanied by diffuse involvement of the extrapulmonary lymph nodes and surrounding soft tissue. The clinicopathological significance of coexistence of pulmonary and extrapulmonary lesions is unknown. METHODS: Here, we report a 16-year-old male patient. The pathological specimens of the supraclavicular lymph node and soft tissue together with the lung biopsy were analyzed by pathological observation and immunohistochemical staining...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29243307/pulmonary-nodules-and-nodular-scleritis-in-a-teenager-with-superficial-granulomatous-pyoderma-gangrenosum
#16
Francisco A Contreras-Verduzco, Sara E Espinosa-Padilla, Luz Orozco-Covarrubias, Adriana Alva-Chaire, César M Rojas-Maruri, Marimar Sáez-de-Ocariz
Superficial granulomatous pyoderma gangrenosum, a rare variant of pyoderma gangrenosum, has been considered to be the most benign form of the disease. We present the case of a 15-year-old boy with pulmonary involvement and nodular scleritis associated with this unusual type of pyoderma gangrenosum and discuss its differential diagnosis.
December 15, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29238021/-granulomatosis-with-polyangiitis-complicated-with-gastrointestinal-perforation-a-case-report-and-review-of-literature
#17
Takao Kiboshi, Kentaro Isoda, Koichi Furukawa, Tomoyuki Wakahara, Kenichiro Otani, Kayo Ueda, Junichi Konma, Kazuhiro Teramura, Nozomi Ueno, Hiroshi Fujiwara, Takeshi Shoda
  A 51-year-old man was detected nasal bleeding, multiple pulmonary nodule and mass, urinalysis abnormality, renal involvement and high titer of proteinase 3-anti-neutrophil cytoplasmic antibody (PR3-ANCA), and was suspected of granulomatosis with polyangiitis and initiated with steroid pulse therapy. On the day after the start of steroid pulse therapy, generalized peritonitis due to ileal perforation occurred, and emergency ileectomy and peritonitis surgery were performed. Induction therapy with steroid pulse therapy, plasma exchange and intravenous cyclophosphamide therapy (IVCY) and maintenance therapy with glucocorticoid and azathioprine led to good therapeutic outcomes...
2017: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29221316/recent-advances-in-the-management-of-pulmonary-tuberculoma-with-focus-on-the-use-of-tubeless-video-assisted-thoracoscopic-surgery
#18
REVIEW
Zhaohua Xia, Kun Qiao, Jianxing He
Pulmonary tuberculoma are benign solitary pulmonary nodules representing up to 25% of all resected solitary pulmonary nodules. However, the differentiation between pulmonary tuberculoma and lung cancer, as well as between active tuberculoma and inactive tuberculoma remains a clinical challenge. The present review summarizes the recent advances in the management of pulmonary tuberculoma, including radiological findings, the response to anti-tuberculosis treatment and surgical treatments. Application of the novel tubeless video-assisted thoracoscopic surgery (VATS) technique in both the diagnosis and treatment of pulmonary tuberculoma has been found to be safe and feasible and leads to less surgical trauma, which results in reduced length of hospitalization and better post-operative quality of life...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29214064/bronchoscopy-for-the-diagnosis-of-peripheral-lung-lesions
#19
REVIEW
Samjot Singh Dhillon, Kassem Harris
Peripheral pulmonary lesions (PPLs) are generally considered as lesions in the peripheral one-third of the lung although a precise definition and radiographic anatomical landmarks separating central and peripheral lesion does not yet exist. The radiographic detection of such lesions has increased significantly with the adoption of lung cancer screening programs. These lesions are not directly visible by regular flexible bronchoscopes as they are usually distal to the lobar and segmental bronchi. Traditionally, depending on location and clinical stage at presentation, these lesions were typically sampled by computerized tomography (CT) guided needle or surgical biopsy although some centers also used ultrasound and fluoroscopy guided percutaneous needle biopsy...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29201223/application-of-positron-emission-tomography-computed-tomography-in-the-diagnosis-of-pulmonary-ground-glass-nodules
#20
Lili Hu, Yuanwei Pan, Zhigang Zhou, Jianbo Gao
The aim of the present study was to investigate the value of positron emission tomography-computed tomography (PET-CT) using 18F-fluorodeoxyglucose in the clinical diagnosis of pulmonary ground-glass nodule. In total, 54 patients with pulmonary GGN that were identified by PET-CT examination were selected and confirmed by pathology and clinical diagnosis in hospital between April 2014 and April 2015. The association between PET-CT findings and pathology, and the value of PET-CT were then evaluated. In the 54 patients, solitary pulmonary GGN with a nodule diameter of between 0...
November 2017: Experimental and Therapeutic Medicine
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