keyword
https://read.qxmd.com/read/38373627/high-incidence-of-sebaceous-gland-inflammation-in-aldose-reductase-deficient-mice
#1
JOURNAL ARTICLE
Anjali Mandava, Binhan Pham, Michelle Pedler, Biehuoy Shieh, Hari Gopalakrishnan, J Mark Petrash
Aldose reductase is a member of the 1B1 subfamily of aldo-keto reductase gene superfamily. The action of aldose reductase (AR) has been implicated in the pathogenesis of a variety of disease states, most notably complications of diabetes mellitus including neuropathy, retinopathy, nephropathy, and cataracts. To explore for mechanistic roles for AR in disease pathogenesis, we established mutant strains produced using Crispr-Cas9 to inactivate the AKR1B3 gene in C57BL6 mice. Phenotyping AR-knock out (ARKO) strains confirmed previous reports of reduced accumulation of tissue sorbitol levels...
February 17, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38272248/mitigation-of-lens-opacification-by-a-functional-food-in-a-diabetic-rodent-model
#2
JOURNAL ARTICLE
Krishna K Kalahasti, Ch Uday Kumar, Marka Nagaraju, J Mark Petrash, S Sreenivasa Reddy, G Bhanuprakash Reddy
The current study was designed to test a functional food (FF) mixture containing aldose reductase inhibitors and anti-glycation bioactive compounds for suppressing the onset and progression of cataracts in a diabetic rat model. Two-month-old Sprague Dawley rats were grouped as control (C), diabetes untreated (D), and diabetic rats treated with FF at two doses (FF1 = 1.35 g and FF2 = 6.25 g/100g of diet). Diabetes was induced by a single injection of streptozotocin. The FF is a mixture of amla, turmeric, black pepper, cinnamon, ginger, and fenugreek added to the rodent diet...
January 23, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38189482/maternal-serum-polyols-and-its-link-to-gestational-diabetes-mellitus-a-population-based-nested-case-control-study
#3
JOURNAL ARTICLE
Xiaoyong Li, Yu Liu, Yicheng Qi, Yiming Wu, Meng Wang, Jing Gao, Qing Su, Jing Ma, Li Qin
CONTEXT: Sugar alcohols (also called polyols) confer a"healthy"sugar substitute. One of possible reasons to support the safe use in pregnant women is their natural origin and the presence of polyols in maternal and fetal samples during normal human gestation. But little is known about the association between circulating sugar alcohols levels and maternal metabolic disorders during pregnancy. OBJECTIVE: We aimed to detect the concentration of the polyols in participants with and without GDM, and to investigate the association between maternal serum levels of polyols and gestational diabetes mellitus (GDM), as well as newborn outcomes...
January 8, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38185272/aldose-reductase-is-a-potential-therapeutic-target-for-neurodegeneration
#4
REVIEW
Mishal Rao, Kun-Che Chang
Neurodegeneration is a complex process involving various inflammatory mediators and cellular responses. Aldose reductase (AR) is a key enzyme in the polyol pathway, which converts glucose to sorbitol. Beyond its metabolic role, AR has also been found to play a significant role in modulating neuroinflammation. This review aims to provide an overview of the current knowledge regarding the involvement of AR inhibition in attenuating neuroinflammation and complications from diabetic neuropathies. Here, we review the literature regarding AR and neuropathy/neurodegeneration...
February 1, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38183105/design-of-mobile-and-website-health-application-devices-for-drug-tolerability-in-hereditary-fructose-intolerance
#5
JOURNAL ARTICLE
Elsa Izquierdo-García, Andrea Lázaro-Cebas, Berta Montero Pastor, Ana Such Díaz, Elena Alba Álvaro-Alonso, Laura López Guerra, Ismael Escobar-Rodríguez
BACKGROUND: Hereditary fructose intolerance (HFI) is a rare metabolic disease caused by aldolase B deficiency. The aim of our study was to analyse excipient tolerability in patients with HFI and other related diseases and to design mobile and website health applications to facilitate the search for drugs according to their tolerance. RESULTS: A total of 555 excipients listed in the Spanish Medicines Agency database (July 2023) were classified as suitable for HFI patients, suitable with considerations ((glucose and glucose syrup, intravenous sucrose, oral mannitol, polydextrose, gums and carrageenans, ethanol, sulfite caramel and vanilla), not recommended (intravenous mannitol) and contraindicated (fructose, oral sucrose, invert sugar, sorbitol, maltitol, lactitol, isomaltitol, fruit syrups, honey, sucrose esters and sorbitol esters)...
January 5, 2024: Orphanet Journal of Rare Diseases
https://read.qxmd.com/read/38127948/discovery-of-a-novel-benzothiadiazine-based-selective-aldose-reductase-inhibitor-as-potential-therapy-for-diabetic-peripheral-neuropathy
#6
JOURNAL ARTICLE
Ruyi Jin, Jin Wang, Mingyue Li, Tian Tang, Yidong Feng, Sha Zhou, Honglei Xie, Haiyu Feng, Jianshuang Guo, Ruijia Fu, Jiping Liu, Yuping Tang, Yajun Shi, Hui Guo, Yuwei Wang, Fayi Nie, Jing Li
Aldose reductase2 (ALR2), an activated enzyme in polyol pathway by hyperglycemia, has long been recognized as one of the most promising targets for diabetic complications especially in diabetic peripheral neuropathy (DPN). However, lots of ALR2 inhibitors showed serious sideeffects due to poor selectivity over aldehyde reductase (ALR1). Herein, we described the discovery of a series of benzothiadiazine acetic acid derivatives as potent and selective inhibitors against ALR2 and evaluation of their anti-DPN activities in vivo...
December 21, 2023: Diabetes
https://read.qxmd.com/read/38111407/aldose-reductase-and-protein-glycation-inhibitory-activity-of-dark-chocolate-assisted-zinc-oxide-nanoparticles
#7
JOURNAL ARTICLE
Vedha R Nair, Geetha R V, Parameswari R P
Introduction One of the most common health issues that the global population is dealing with is the associated complications of diabetes, which encompasses cataracts, peripheral neuropathy, vascular damage, impaired wound healing, retinal issues, and arterial wall stiffening. The present study is aimed to evaluate the effect of dark chocolate and its assisted zinc oxide nanoparticles against diabetes-associated complications. Materials and methods Zinc oxide nanoparticles were synthesized using commercially dark chocolate (DC-ZnO NP)...
November 2023: Curēus
https://read.qxmd.com/read/38105348/naringenin-hesperidin-and-quercetin-ameliorate-radiation-induced-damage-in-rats-in-vivo-and-in-silico-evaluations
#8
JOURNAL ARTICLE
Handan Uguz, Bahri Avcı, Esra Palabıyık, Ayşe Nurseli Sulumer, Hilal Kızıltunç Özmen, Yeliz Demir, Hakan Aşkın
In this study, we sought to determine how well naringenin, hesperidin, and quercetin prevented damage brought on by radiotherapy. During the investigation, 48 adult female Sprague Dawley rats were used. Eight groups of eight rats each were formed by randomly assigning the rats to the groups. The normal control group was represented by Group 1. Group 2 rats were those that received a dose of 15 Gray (Gy) of radiotherapy. The rats assigned to Group 3 received only Naringenin, whereas those assigned to Group 4 received only quercetine, and those assigned to Group 5 received only hesperidin...
December 17, 2023: Chemistry & Biodiversity
https://read.qxmd.com/read/38070508/atlas-of-fetal-metabolism-during-mid-to-late-gestation-and-diabetic-pregnancy
#9
REVIEW
Cesar A Perez-Ramirez, Haruko Nakano, Richard C Law, Nedas Matulionis, Jennifer Thompson, Andrew Pfeiffer, Junyoung O Park, Atsushi Nakano, Heather R Christofk
Mounting evidence suggests metabolism instructs stem cell fate decisions. However, how fetal metabolism changes during development and how altered maternal metabolism shapes fetal metabolism remain unexplored. We present a descriptive atlas of in vivo fetal murine metabolism during mid-to-late gestation in normal and diabetic pregnancy. Using 13 C-glucose and liquid chromatography-mass spectrometry (LC-MS), we profiled the metabolism of fetal brains, hearts, livers, and placentas harvested from pregnant dams between embryonic days (E)10...
January 4, 2024: Cell
https://read.qxmd.com/read/38014333/differential-responses-of-primary-neuron-secreted-mcp-1-and-il-9-to-type-2-diabetes-and-alzheimer-s-disease-associated-metabolites
#10
Brendan K Ball, Madison K Kuhn, Rebecca M Fleeman, Elizabeth A Proctor, Douglas K Brubaker
Type 2 diabetes (T2D) is implicated as a risk factor for Alzheimer's disease (AD), the most common form of dementia. In this work, we investigated neuroinflammatory responses of primary neurons to potentially circulating, blood-brain barrier (BBB) permeable metabolites associated with AD, T2D, or both. We identified nine metabolites associated with protective or detrimental properties of AD and T2D in literature (lauric acid, asparagine, fructose, arachidonic acid, aminoadipic acid, sorbitol, retinol, tryptophan, niacinamide) and stimulated primary mouse neuron cultures with each metabolite before quantifying cytokine secretion via Luminex...
November 17, 2023: bioRxiv
https://read.qxmd.com/read/37971280/bioequivalence-study-of-epalrestat-for-healthy-chinese-subjects
#11
JOURNAL ARTICLE
Dandan Yang, Xiaodan Wang, Yi Duan, Yichao Xu, Zourong Ruan, Bo Jiang, Honggang Lou, Jinliang Chen
Epalrestat is a reversible noncompetitive inhibitor of aldose reductase with selective inhibition of aldose reductase. It can inhibit the accumulation of sorbitol in red blood cells in patients with diabetic peripheral neuropathy and can improve patients' conscious symptoms and neurological dysfunction. This study was designed to evaluate the bioequivalence in healthy Chinese subjects of a new test formulation and reference formulation of oral epalrestat (50 mg) in the fasting state. The study was performed with 44 healthy Chinese subjects according to a randomized 2-way crossover design...
November 16, 2023: Clinical Pharmacology in Drug Development
https://read.qxmd.com/read/37928946/search-of-inhibitors-of-aldose-reductase-for-treatment-of-diabetic-cataracts-using-machine-learning
#12
JOURNAL ARTICLE
Trevor Chen, Richard Chen, Alvin You, Valentina L Kouznetsova, Igor F Tsigelny
PURPOSE: Patients with diabetes mellitus have an elevated chance of developing cataracts, a degenerative vision-impairing condition often needing surgery. The process of the reduction of glucose to sorbitol in the lens of the human eye that causes cataracts is managed by the Aldose Reductase Enzyme (AR), and it is been found that AR inhibitors may mitigate the onset of diabetic cataracts. There exists a large pool of natural and synthetic AR inhibitors that can prevent diabetic complications, and the development of a machine-learning (ML) prediction model may bring new AR inhibitors with better characteristics into clinical use...
2023: Adv Ophthalmol Pract Res
https://read.qxmd.com/read/37914263/in-silico-studies-anti-oxidant-properties-antisorbitol-dehydrogenase-anti-alpha-amylase-and-anti-gastrointestinal-cancer-potential-of-violanthin-as-a-natural-compound
#13
JOURNAL ARTICLE
Zhu Zhong, Zhongwei Chen, Jia Liu, Abdurahman Hajinur Hirad, Jun Sun
In vitro studies have shown flavonoids to be effective antioxidants. Flavonoid C-glycosides have antioxidant properties, but there are very few data on their cellular antioxidant activity. The chemical activities of violanthin against alpha amylase and sorbitol dehydrogenase were investigated utilizing the molecular docking study. The anti-cancer activities of the compounds were evaluated against MKN45, AGS, and KATO III cell lines. The chemical activities of violanthin against some of the expressed surface receptor proteins (estrogen receptor, folate receptor, and CD44) in the mentioned cell lines were estimated using molecular docking calculations...
2023: Journal of Oleo Science
https://read.qxmd.com/read/37877034/c2c12-muscle-myotubes-but-not-kidney-proximal-tubule-hk-2-cells-elevate-erythritol-synthesis-in-response-to-oxidative-stress
#14
JOURNAL ARTICLE
Semira R Ortiz, Martha S Field
BACKGROUND: As a biomarker, elevated serum erythritol concentrations predict type 2 diabetes and cardiovascular disease onset. Erythritol was recently shown to be a product of human glucose metabolism through the pentose phosphate pathway. The regulation of erythritol synthesis from glucose has been explored in cancer cells but not in nontransformed cells. OBJECTIVE: The kidneys and skeletal muscle have increased erythritol content in response to dietary sucrose, which suggests that they may significantly contribute to circulating erythritol concentrations...
October 2023: Current Developments in Nutrition
https://read.qxmd.com/read/37867268/new-horizons-in-diabetic-neuropathies-an-updated-review-on-their-pathology-diagnosis-mechanism-screening-techniques-pharmacological-and-future-approaches
#15
JOURNAL ARTICLE
Namra Aziz, Biswajit Dash, Pranay Wal, Prachi Kumari, Poonam Joshi, Ankita Wal
BACKGROUND: One of the largest problems for global public health is diabetes mellitus (DM) and its micro and macrovascular consequences. Although prevention, diagnosis, and treatment have generally improved, its incidence is predicted to keep rising over the coming years. Due to the intricacy of the molecular mechanisms, which include inflammation, oxidative stress, and angiogenesis, among others, discovering treatments to stop or slow the course of diabetic complications is still a current unmet need...
October 20, 2023: Current Diabetes Reviews
https://read.qxmd.com/read/37817655/nutritional-profile-gc-ms-analysis-and-in-silico-anti-diabetic-phytocompounds-candidature-of-jatropha-gossypifolia-leaf-extracts
#16
JOURNAL ARTICLE
Olasunkanmi Kayode Awote, Rahmon Ilesanmi Kanmodi, Success Chidera Ebube, Zainab Folashade Abdulganniyyu
BACKGROUND: Diabetes mellitus (DM) is a metabolic disorder known to impair many physiological functions via reactive oxygen species (ROS). Aldose reductase, Sorbitol dehydrogenase, Dipeptidyl peptidase IV, α-amylase and α-glucosidase are pharmacotherapeutic protein targets in type-2 diabetes. Inhibitors of these enzymes constitute a new class of drugs used in the treatment and management of type-2 diabetes mellitus. Some reports claim that medicinal plant extracts used as food (antioxidant source) can reduce these alterations by eliminating ROS caused by DM...
October 10, 2023: Current Drug Discovery Technologies
https://read.qxmd.com/read/37793822/anti-lung-cancer-anti-microbial-anti-%C3%AE-glucosidase-anti-sorbitol-dehydrogenase-and-in-silico-studies-of-wogonoside-and-isoliquiritigenin-as-natural-compounds
#17
JOURNAL ARTICLE
Xiancong Zeng, Mengxia Zhao, Hefeng Yao
Natural substances have long been used in cancer treatment, particularly in Chinese or Indian traditional medicine. Natural compounds are defined as chemical molecules that are found in fungus, marine animals, plants, or bacteria and have significant biological and pharmacological effects. Wogonoside and isoliquiritigenin are two well-known examples of plant-derived chemicals. Several modern anti-cancer medications also come from natural sources. The mic test was used to conduct tests on various natural substances' antimicrobial and antifungal properties...
2023: Journal of Oleo Science
https://read.qxmd.com/read/37788831/identification-of-potential-aldose-reductase-inhibitors-using-convolutional-neural-network-based-in-silico-screening
#18
JOURNAL ARTICLE
Kushagra Kashyap, Pinaki Prasad Mahapatra, Shakil Ahmed, Erdem Buyukbingol, Mohammad Imran Siddiqi
Aldose reductase (ALR2) is a notable enzyme of the polyol pathway responsible for aggravating diabetic neuropathy complications. The first step begins when it catalyzes the reduction of glucose to sorbitol with NADPH as a coenzyme. Elevated concentrations of sorbitol damage the tissues, leading to complications like neuropathy. Though considerable effort has been pushed toward the successful discovery of potent inhibitors, its discovery still remains an elusive task. To this end, we present a 3D convolutional neural network (3D-CNN) based ALR2 inhibitor classification technique by dealing with snapshots of images captured from 3D chemical structures with multiple rotations as input data...
October 3, 2023: Journal of Chemical Information and Modeling
https://read.qxmd.com/read/37649296/the-role-of-aldose-reductase-in-polyol-pathway-an-emerging-pharmacological-target-in-diabetic-complications-and-associated-morbidities
#19
JOURNAL ARTICLE
Jeetendra Kumar Gupta
The expression of aldose reductase leads to a variety of biological and pathological effects. It is a multifunctional enzyme which has a tendency to reduce aldehydes to the corresponding sugar alcohol. In diabetic conditions, the aldose reductase enzyme converts glucose into sorbitol using nicotinamide adenine dinucleotide phosphate as a cofactor. It is a key enzyme in polyol pathway which is a surrogate course of glucose metabolism. The polyol pathway has a significant impact on the aetiology of complications in individuals with end-stage diabetes...
August 30, 2023: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/37623837/metabolites-potentially-derived-from-gut-microbiota-associated-with-podocyte-proximal-tubule-and-renal-and-cerebrovascular-endothelial-damage-in-early-diabetic-kidney-disease-in-t2dm-patients
#20
JOURNAL ARTICLE
Lavinia Balint, Carmen Socaciu, Andreea Iulia Socaciu, Adrian Vlad, Florica Gadalean, Flaviu Bob, Oana Milas, Octavian Marius Cretu, Anca Suteanu-Simulescu, Mihaela Glavan, Silvia Ienciu, Maria Mogos, Dragos Catalin Jianu, Sorin Ursoniu, Victor Dumitrascu, Daliborca Vlad, Roxana Popescu, Ligia Petrica
Complications due to type 2 diabetes mellitus (T2DM) such as diabetic kidney disease (DKD) and cerebral small vessel disease (CSVD) have a powerful impact on mortality and morbidity. Our current diagnostic markers have become outdated as T2DM-related complications continue to develop. The aim of the investigation was to point out the relationship between previously selected metabolites which are potentially derived from gut microbiota and indicators of endothelial, proximal tubule (PT), and podocyte dysfunction, and neurosonological indices...
July 28, 2023: Metabolites
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