keyword
MENU ▼
Read by QxMD icon Read
search

Sorbitol

keyword
https://www.readbyqxmd.com/read/28821765/the-protective-action-of-osmolytes-on-the-deleterious-effects-of-gamma-rays-and-atmospheric-pressure-plasma-on-protein-conformational-changes
#1
Pankaj Attri, Minsup Kim, Thapanut Sarinont, Eun Ha Choi, Hyunwoong Seo, Art E Cho, Kazunori Koga, Masaharu Shiratani
Both gamma rays and atmospheric pressure plasma are known to have anticancer properties. While their mechanism actions are still not clear, in some contexts they work in similar manner, while in other contexts they work differently. So to understand these relationships, we have studied Myoglobin protein after the treatment of gamma rays and dielectric barrier discharge (DBD) plasma, and analyzed the changes in thermodynamic properties and changes in the secondary structure of protein after both treatments. The thermodynamic properties were analyzed using chemical and thermal denaturation after both treatments...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821127/a-comparative-study-on-cellulose-nanocrystals-extracted-from-bleached-cotton-and-flax-and-used-for-casting-films-with-glycerol-and-sorbitol-plasticisers
#2
Emilia Csiszár, Sebestyén Nagy
Cellulose nanocrystals (CNCs) were released from bleached cotton and flax by a sulphuric acid hydrolysis with about 40 and 34% yield, respectively. The rod-like cotton-CNC particles were slightly longer and wider and had a less pronounced aggregation ability in aqueous suspension than the flax-CNC ones. Films were cast from the CNC suspensions with sorbitol and glycerol plasticisers. The concept behind this research was to explore how the plasticisers - with similar structure but different molecular weight - and their concentrations affect the perceptible and measured properties of CNC films...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28820747/involvement-of-hyperglycemia-in-the-development-of-platelet-procoagulant-response-the-role-of-aldose-reductase-and-platelet-swelling
#3
Tomasz Rusak, Tomasz Misztal, Malgorzata Rusak, Justyna Branska-Januszewska, Marian Tomasiak
: Rise in mean platelet volume (MPV) has been demonstrated to be associated with increased platelet reactivity. In diabetes patients, augmented MPV was proposed to contribute to increased risk of thrombotic complications. Therefore, the aim of this study was to investigate whether under hyperglycemic conditions, aldose reductase (AR)-mediated sorbitol formation and associated rise in cell volume, which subsequently results in platelet hyperactivation. Platelets were obtained from 30 healthy volunteers and 13 patients with diabetes...
September 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/28819874/effect-of-elicitors-on-the-production-of-pyrroloquinazoline-alkaloids-by-stimulating-anthranilate-synthase-activity-in-adhatoda-vasica-nees-cell-cultures
#4
Bharat Singh, Pooran M Sahu, Ram A Sharma
Pyrroloquinazoline alkaloids are medicinally important compounds, determined by HPLC from cell cultures of Adhatoda vasica . The maximum production of vasicinone (12-fold) and vasicine (8.3-fold) was enhanced by stimulating the anthranilate synthase activity via feeding of tryptophan and sorbitol. The decoction of Adhatoda vasica leaves is used for the treatment of throat irritations, inflammations and recommended as expectorant. The plant species contains pyrroloquinazoline alkaloids and has been reported to demonstrate various biological activities...
August 17, 2017: Planta
https://www.readbyqxmd.com/read/28810774/effect-of-solute-nature-on-the-polyamorphic-transition-in-glassy-polyol-aqueous-solutions
#5
Yoshiharu Suzuki
I examined the polyamorphic behavior of glassy dilute aqueous solutions of polyols (ethylene glycol, glycerol, meso-erythritol, xylitol, and D-sorbitol) under pressure at low temperatures. Although the volume change of the glassy aqueous solution varied continuously against pressure, the rate of the volume change appeared to vary discontinuously at the onset pressure of the gradual polyamorphic transition. It is thought that low-density liquid-like solvent water and high-density liquid-like solvent water coexist during the transition...
August 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28810704/yeast-kch1-and-kch2-membrane-proteins-play-a-pleiotropic-role-in-membrane-potential-establishment-and-monovalent-cation-homeostasis-regulation
#6
Kristina Felcmanova, Petra Neveceralova, Hana Sychrova, Olga Zimmermannova
The Kch1 and Kch2 plasma-membrane proteins were identified in Saccharomyces cerevisiae as being essential for the activation of a high-affinity Ca2+ influx system. We searched for Kch proteins roles in the maintenance of cation homeostasis and tested the effect of kch1 and/or kch2 deletions on various physiological parameters. Compared to wild-type, kch1 kch2 mutant cells were smaller, relatively hyperpolarised, grew better under limited K+ conditions and exhibited altered growth in the presence of monovalent cations...
August 1, 2017: FEMS Yeast Research
https://www.readbyqxmd.com/read/28801371/small-intestinal-bacterial-overgrowth-may-increase-the-likelihood-of-lactose-and-sorbitol-but-not-fructose-intolerance-false-positive-diagnosis
#7
Tsachi Tsadok Perets, Dalal Hamouda, Olga Layfer, Olga Ashorov, Doron Boltin, Sigal Levy, Yaron Niv, Ram Dickman
BACKGROUND: Small intestinal bacterial overgrowth (SIBO) is defined as a bacterial count of more than 10(5) colony-forming units per milliliter in duodenal aspirate. It shares many symptoms with carbohydrate intolerance, which makes the clinical distinction of the disorders difficult. The aim of the study was to examine the relationship between a positive carbohydrate breath test and the presence of SIBO suggested by a positive lactulose hydrogen breath test. METHODS: The electronic database of the gastroenterology laboratory of a tertiary medical center was searched for all patients clinically tested for SIBO in 2012-2013 for whom previous results for lactose, fructose, and/or sorbitol breath test were available...
August 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28794311/functional-oil-from-black-seed-differentially-inhibits-aldose-reductase-and-ectonucleotidase-activities-by-up-regulating-cellular-energy-in-haloperidol-induced-hepatic-toxicity-in-rat-liver
#8
Akintunde Jacob Kehinde
In this study, the effect of rate-limiting enzymes involved in degradation of hepatic adenosine and intracellular sorbitol was investigated in rats exposed to haloperidol (HAL) and treated with functional oil (FO), containing principal active phytochemicals from black seed. Animals were divided into six groups (n=10): Distilled water, HAL 15 mg/kg, pre-administration/HAL 15 mg/kg, co-administration/HAL 15 mg/kg, post-administration/HAL 15 mg/kg, FO 150 mg/kg. The results of this study revealed that the activities of ectonucleotidase and aldose-reductase were significantly increased in HAL-treated rats when compared with the control (p < 0...
August 8, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28776673/molecular-characterization-of-excipients-preferential-interactions-with-therapeutic-monoclonal-antibodies
#9
Jehoon Kim, Mark R H Krebs, Bernhardt L Trout
OBJECTIVES: This study reports global and local monoclonal antibody (mAb)-excipient interactions and the resulting thermodynamic and stabilization effects. METHODS: Molecular dynamics simulations are applied to quantify the interactions of key excipients (sucrose, sorbitol, arginine, citrate, histidine and NaCl) used in the formulations of three mAbs. The dynamic surface properties of the mAbs and preferential interaction coefficients for the excipients based on validated potential parameters are computed, in addition to the spatial aggregation propensity...
August 4, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28772825/flame-retardancy-of-carbon-fibre-reinforced-sorbitol-based-bioepoxy-composites-with-phosphorus-containing-additives
#10
Andrea Toldy, Péter Niedermann, Ákos Pomázi, György Marosi, Beáta Szolnoki
Carbon fibre reinforced flame-retarded bioepoxy composites were prepared from commercially available sorbitol polyglycidyl ether (SPE) cured with cycloaliphatic amine hardener. Samples containing 1, 2, and 3% phosphorus (P) were prepared using additive type flame retardants (FRs) resorcinol bis(diphenyl phosphate) (RDP), ammonium polyphosphate (APP), and their combinations. The fire performance of the composites was investigated by limiting oxygen index (LOI), UL-94 tests, and mass loss calorimetry. The effect of FRs on the glass transition temperature, and storage modulus was evaluated by dynamic mechanical analysis (DMA), while the mechanical performance was investigated by tensile, bending, and interlaminar shear measurements, as well as by Charpy impact test...
April 27, 2017: Materials
https://www.readbyqxmd.com/read/28769974/flavonoid-accumulation-plays-an-important-role-in-the-rust-resistance-of-malus-plant-leaves
#11
Yanfen Lu, Qi Chen, Yufen Bu, Rui Luo, Suxiao Hao, Jie Zhang, Ji Tian, Yuncong Yao
Cedar-apple rust (Gymnosporangium yamadai Miyabe) is a fungal disease that causes substantial injury to apple trees and results in fruit with reduced size and quality and a lower commercial value. The molecular mechanisms underlying the primary and secondary metabolic effects of rust spots on the leaves of Malus apple cultivars are poorly understood. Using HPLC, we found that the contents of flavonoid compounds, especially anthocyanin and catechin, were significantly increased in rust-infected symptomatic tissue (RIT)...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28766915/metabolomics-analysis-reveals-distinct-profiles-of-nonmuscle-invasive-and-muscle-invasive-bladder-cancer
#12
Divya Sahu, Yair Lotan, Bryan Wittmann, Bruce Neri, Donna E Hansel
Urothelial carcinoma is the most common form of bladder cancer, but pathway changes that occur with stage-wise progression have not been well defined. We used a metabolomics approach to identify potential metabolic pathways uniquely altered in normal urothelium, nonmuscle-invasive bladder cancer (NMIBC), and muscle-invasive bladder cancer (MIBC). We performed global metabolomic profiling using GC-mass spectrometry (MS) and LC-MS platforms to identify metabolite signatures between normal urothelium and high-grade urothelial carcinoma of different stages...
August 1, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28766033/antifungal-mechanism-of-the-combination-of-cinnamomum-verum-and-pelargonium-graveolens-essential-oils-with-fluconazole-against-pathogenic-candida-strains
#13
Rym Essid, Majdi Hammami, Dorra Gharbi, Ines Karkouch, Thouraya Ben Hamouda, Salem Elkahoui, Ferid Limam, Olfa Tabbene
The present study aimed to investigate the anti-Candida activity of ten essential oils (EOs) and to evaluate their potential synergism with conventional drugs. The effect on secreted aspartic protease (SAP) activity and the mechanism of action were also explored. The antifungal properties of essential oils were investigated using standard micro-broth dilution assay. Only Cinnamomum verum, Thymus capitatus, Syzygium aromaticum, and Pelargonium graveolens exhibited a broad spectrum of activity against a variety of pathogenic Candida strains...
August 1, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28759789/changes-in-carbohydrate-levels-and-relative-water-content-rwc-to-distinguish-dormancy-phases-in-sweet-cherry
#14
Heiko Kaufmann, Michael Blanke
Perennial trees require chilling, i.e. a period of cold temperature in the winter, for flowering next spring; sweet cherry is particularly prone to lack of chilling. The objective of this study is to identify possible transition points to clearly distinguish dormancy phases by relating carbohydrate and relative water content (RWC) in reproductive buds to concomitant chilling fulfilment. This contribution proposes the use of four transition points between the dormancy phases and their characterization in terms of carbohydrates, water contents in combination with chilling values and may allow upscaling to other dormancy studies in trees; two groups of cherry varieties were defined based on their different initial sorbitol and starch level in the autumn...
July 19, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28758816/the-interactions-of-cephalosporins-on-polyol-pathway-enzymes-from-sheep-kidney
#15
Bülent Şengül, Şükrü Beydemir
CONTEXT: Cephalosporins are derived from the fungus Acremonium. Due to their strong bactericidal ability, these drugs have to a wide usage in medicine. OBJECTIVE: An investigation of the effects on sheep renal aldose reductase (AR) and sorbitol dehydrogenase (SDH) of cefoperazone, cefazolin, cefuroxime, ceftazidime and ceftriaxone as cephalosporin drugs was carried out in the present study. METHODS: AR and SDH were purified from sheep kidney by ion exchange, gel filtration and affinity methods with approximately 219- and 484-fold, respectively...
July 31, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28755991/optimization-of-high-concentration-endostatin-formulation-harmonization-of-excipients-contributions-on-colloidal-and-conformational-stabilities
#16
Shujing Wang, Xinyi Zhang, Guoliang Wu, Zhou Tian, Feng Qian
Recently, increasing research efforts have been devoted into developing high-concentration protein drugs for subcutaneous injection, especially for those with short half-lives and high-dose requirement. Proteins at high concentrations normally present increased colloidal and structural instability, such as aggregation, fibrillation and gelation, which significantly challenges the high-concentration formulation development of protein drugs. Here we used endostatin, a 20kD recombinant protein, as a model drug for high-concentration formulation optimization...
July 26, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28754261/elucidating-the-weak-protein-protein-interaction-mechanisms-behind-the-liquid-liquid-phase-separation-of-a-mab-solution-by-different-types-of-additives
#17
Guoliang Wu, Shujing Wang Co-First, Zhou Tian, Ning Zhang, Han Sheng, Weiguo Dai, Feng Qian
Liquid-liquid phase separation (LLPS) has long been observed during the physical stability investigation of therapeutic protein formulations. The buffer conditions and the presence of various excipients are thought to play important roles in the formulation development of monoclonal antibodies (mAbs). In this study, the effects of several small-molecule excipients (histidine, alanine, glycine, sodium phosphate, sodium chloride, sorbitol and sucrose) with diverse physical-chemical properties on LLPS of a model IgG1 (JM2) solutions were investigated by multiple techniques, including UV-vis spectroscopy, circular dichroism, differential scanning calorimetry/fluorimetry, size exclusion chromatography and dynamic light scattering...
July 25, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28745839/transcription-factor-agseb1-affects-development-osmotic-stress-response-and-secondary-metabolism-in-marine-derived-aspergillus-glaucus
#18
Yuan Wu, Yanna Ren, Xiangshan Zhou, Menghao Cai, Yuanxing Zhang
Fungi possess sophisticated regulatory systems to respond to a vast array of environmental signals. Among these responsive networks, some genes play critical roles in the regulation of various cellular processes. Here, we identified a putative transcriptional factor Agseb1 in Aspergillus glaucus, a marine-derived filamentous fungus. Agseb1 encodes a protein with two C2 H2 zinc fingers at the C-terminus, similar to the placement of these motifs in msn2/4 of Saccharomyces cerevisia, where they are positioned to allow binding to the CCCCT-box of stress-specific genes...
July 26, 2017: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/28727605/in-vitro-compatibility-of-contact-lenses-with-corneal-epithelial-cells
#19
Ajay K Vijay, Zohra Fadli, Carol Lakkis, Chantal Coles-Brennan, Mark D P Willcox
PURPOSE: To determine the interaction of contact lenses of different materials with corneal epithelial cells grown in tissue culture. METHODS: Two different corneal epithelial cell lines were grown to confluence in culture media. Two hydrogel contact lenses with and without polyvinylpyrrolidone (PVP) {1-DAY ACUVUE MOIST (1-Day ACUVUE [hydrogel lenses]) and a silicone hydrogel contact lens, AIR OPTIX NIGHT & DAY} were removed from their blister packs, washed in phosphate-buffered saline, and applied to the cells...
July 18, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28727570/hyperosmotic-stress-stimulates-autophagy-via-polycystin-2
#20
Daniel Peña-Oyarzun, Rodrigo Troncoso, Catalina Kretschmar, Cecilia Hernando, Mauricio Budini, Eugenia Morselli, Sergio Lavandero, Alfredo Criollo
Various intracellular mechanisms are activated in response to stress, leading to adaptation or death. Autophagy, an intracellular process that promotes lysosomal degradation of proteins, is an adaptive response to several types of stress. Osmotic stress occurs under both physiological and pathological conditions, provoking mechanical stress and activating various osmoadaptive mechanisms. Polycystin-2 (PC2), a membrane protein of the polycystin family, is a mechanical sensor capable of activating the cell signaling pathways required for cell adaptation and survival...
July 5, 2017: Oncotarget
keyword
keyword
75060
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"