keyword
MENU ▼
Read by QxMD icon Read
search

Sorbitol

keyword
https://www.readbyqxmd.com/read/28436957/pyruvate-kinase-m2-activation-may-protect-against-the-progression-of-diabetic-glomerular-pathology-and-mitochondrial-dysfunction
#1
Weier Qi, Hillary A Keenan, Qian Li, Atsushi Ishikado, Aimo Kannt, Thorsten Sadowski, Mark A Yorek, I-Hsien Wu, Samuel Lockhart, Lawrence J Coppey, Anja Pfenninger, Chong Wee Liew, Guifen Qiang, Alison M Burkart, Stephanie Hastings, David Pober, Christopher Cahill, Monika A Niewczas, William J Israelsen, Liane Tinsley, Isaac E Stillman, Peter S Amenta, Edward P Feener, Matthew G Vander Heiden, Robert C Stanton, George L King
Diabetic nephropathy (DN) is a major cause of end-stage renal disease, and therapeutic options for preventing its progression are limited. To identify novel therapeutic strategies, we studied protective factors for DN using proteomics on glomeruli from individuals with extreme duration of diabetes (ł50 years) without DN and those with histologic signs of DN. Enzymes in the glycolytic, sorbitol, methylglyoxal and mitochondrial pathways were elevated in individuals without DN. In particular, pyruvate kinase M2 (PKM2) expression and activity were upregulated...
April 24, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28425323/enhanced-solubility-of-piperine-using-hydrophilic-carrier-based-potent-solid-dispersion-systems
#2
Thenmozhi Kathavarayan, Young Je Yoo
CONTEXT: Piperine alkaloid, an important constituent of black pepper exhibits numerous therapeutic properties whereas its usage as a drug is limited due to its poor solubility in aqueous medium, which leads to poor bioavailability. OBJECTIVE: Herein a new method has been developed to improve the solubility of this drug based on the development of solid dispersions with improved dissolution rate using hydrophilic carriers such as sorbitol (Sor), polyethylene glycol (PEG) and polyvinyl pyrrolidone K30 (PVP) by solvent method...
April 20, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28422384/natural-antioxidant-flavonoids-in-formalin-induced-mice-paw-inflammation-inhibition-of-mitochondrial-sorbitol-dehydrogenase-activity
#3
Ebtehal Mohammad F, Wedad A Hasan, Eman G Mohamed
Flavonoids have reported to cover interesting multiple pharmacological properties. This study evaluated the effect of apigenin or silymarin in paw inflammation induced by formalin in mice. Mice were divided into four groups: I: positive control group; II: apigenin, 3 mg/kg (i.p.); III: silymarin 50 mg/kg (p.o.); IV: meloxicam 10 mg/kg (p.o.), the reference drug. Therapies were administered once a day for 7 days. The curative effects were assessed on inflammatory, oxidative stress and neurotransmitter biomarkers, and apoptosis...
April 19, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28420061/metabolic-profiling-reveals-new-serum-biomarkers-of-lupus-nephritis
#4
J Li, X-W Xie, H Zhou, B Wang, M-J Zhang, F-Y Tang
Metabolomics has been applied to explore altered metabolite profiles in disease and identify unique metabolic signatures specific to certain pathologies. The aim of the current study is to characterize the metabolic profile of patients diagnosed with lupus nephritis (LN) and explore new insights into underlying disease processes. A metabolomic approach using ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry (UPLC-HRMS) was developed in serum samples from 32 LN patients, 30 idiopathic nephrotic syndrome (INS) patients and 28 healthy controls (HCs)...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28417465/effects-of-rare-sugar-d-allulose-on-heat-induced-gelation-of-surimi-prepared-from-marine-fish
#5
Masahiro Ogawa, Masaki Inoue, Shigeru Hayakawa, Siwaporn O'Charoen, Makiko Ogawa
BACKGROUND: d-allulose (Alu), the C3-epimer of D-fructose, is noncalorie sweetener (0.39 kcal g(-1) ) with a suppressive effect on postprandial blood glucose elevation. The aim of this study was to investigate the effects of Alu used as sweetener and gel improver instead of sucrose on heat-induced gelation of surimi. RESULTS: The puncture test of a heat-induced surimi gel showed that the surimi gel with 50 g kg(-1) . Alu had 15 and 6 % higher gel strength than the counterpart gel with sucrose (Suc) and that with sorbitol (Sor), respectively...
April 18, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28407891/antioxidants-and-%C3%AE-glucosidase-inhibitors-from-liucha-young-leaves-and-shoots-of-sibiraea-laevigata
#6
Jian-Qiang Zhao, Yan-Ming Wang, Yan-Long Yang, Ying Zeng, Li-Juan Mei, Yan-Ping Shi, Yan-Duo Tao
The young leaves and shoots of Sibiraea laevigata, known as "Liucha", are used as tea by Tibetans to improve digestion after meals. Long-term consumption of "Liucha" will cause weight loss. In present work, we reported on the isolation and NMR and chemical analysis-based elucidation of seven new sorbitol O-caffeic acid ester derivatives named sorbitol esters A-G (1-7) and eighteen known phenolic compounds from S. laevigata. All of the isolates were evaluated for their antioxidant and α-glucosidase inhibitory activities...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28401458/purification-characterization-and-thermostability-improvement-of-xylanase-from-bacillus-amyloliquefaciens-and-its-application-in-pre-bleaching-of-kraft-pulp
#7
Sharad Kumar, Izharul Haq, Jyoti Prakash, Sudheer Kumar Singh, Shivaker Mishra, Abhay Raj
Xylanases have important industrial applications but are most extensively utilized in the pulp and paper industry as a pre-bleaching agent. We characterized a xylanase from Bacillus amyloliquefaciens strain SK-3 and studied it for kraft pulp bleaching. The purified enzyme had a molecular weight of ~50 kDa with optimal activity at pH 9.0 and 50 °C. The enzyme showed good activity retention (85%) after 2 h incubation at 50 °C and pH 9.0. This enzyme obeyed Michaelis-Menten kinetics with regard to beechwood xylan with K m and V max values of 5...
May 2017: 3 Biotech
https://www.readbyqxmd.com/read/28401430/bilateral-effects-of-excipients-on-protein-stability-preferential-interaction-type-of-excipient-and-surface-aromatic-hydrophobicity-of-protein
#8
Lili Wen, Xianxian Zheng, Xinyue Wang, Hairong Lan, Zongning Yin
PURPOSE: Understanding the mechanism of protein-excipient interaction and illuminating the influencing factors on protein stability are key steps in the rational design of protein formulations. The objective of this study was to assess effects of preferential interaction type of excipient and surface aromatic hydrophobicity of protein on protein solution stability. METHODS: The preferential interaction between excipient and aromatic hydrophobic area of protein was investigated by solubility and fluorescence studies of amino acid derivatives in excipient solutions...
April 11, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28396712/interplay-of-chemical-and-thermal-gradient-on-bacterial-migration-in-a-diffusive-microfluidic-device
#9
Nithya Murugesan, Purbarun Dhar, Tapobrata Panda, Sarit K Das
Living systems are constantly under different combinations of competing gradients of chemical, thermal, pH, and mechanical stresses allied. The present work is about competing chemical and thermal gradients imposed on E. coli in a diffusive stagnant microfluidic environment. The bacterial cells were exposed to opposing and aligned gradients of an attractant (1 mM sorbitol) or a repellant (1 mM NiSO4) and temperature. The effects of the repellant/attractant and temperature on migration behavior, migration rate, and initiation time for migration have been reported...
March 2017: Biomicrofluidics
https://www.readbyqxmd.com/read/28393159/self-assembly-behaviors-of-dibenzylidene-sorbitol-hybrid-organogels-with-inorganic-silica
#10
Wei-Chi Lai, Po-Hsun Huang
Molecular interactions, rheological behaviors and microstructures of 1,3:2,4-dibenzylidene-d-sorbitol (DBS)/poly(ethylene glycol) (PEG) organogel-inorganic silica hybrid materials are discussed in this study. DBS can dissolve in low-molecular-weight PEG to form organogels. The self-assembly behavior of these organogels was significantly influenced by the addition of the inorganic silica. The π interactions between the phenyl rings of DBS were not influenced by silica addition; however, the addition of silica affected the intermolecular hydrogen bonding of DBS, which interacts with PEG...
April 10, 2017: Soft Matter
https://www.readbyqxmd.com/read/28390875/effect-of-non-nutritive-sugars-to-decrease-the-survivorship-of-spotted-wing-drosophila-drosophila-suzukii
#11
Man-Yeon Choi, Siew Bee Tang, Seung-Joon Ahn, Kaushalya G Amarasekare, Peter Shearer, Jana C Lee
In this study, we investigated the effects of non-nutritive sugars and sugar alcohols on the survivorship of spotted wing drosophila, Drosophila suzukii, and found erythritol and erythrose as potentially insecticidal to the fly. In a dose-dependent study, erythritol and erythrose significantly reduced fly longevity, with 100% mortality with 1, 0.5, 0.1 & 0.05M doses after feeding for 7days. When sucrose and erythritol solutions were provided separately to flies for 7days, there was no effect on survivorship regardless of erythritol concentrations...
April 5, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28385729/modelling-of-dolichol-mass-spectra-isotopic-envelopes-as-a-tool-to-monitor-isoprenoid-biosynthesis
#12
Adam Jozwiak, Agata Lipko, Magdalena Kania, Witold Danikiewicz, Liliana Surmacz, Agnieszka Witek, Jacek Wojcik, Konrad Zdanowski, Cezary Pączkowski, Tadeusz Chojnacki, Jaroslaw Poznanski, Ewa Swiezewska
The co-operation of the mevalonate (MVA) and methylerythritol phosphate (MEP) pathways, operating in parallel in plants to generate isoprenoid precursors, has been studied extensively. Elucidation of the isoprenoid metabolic pathways is indispensable for rational design of plant and microbial systems for production of industrially valuable terpenoids. Here we describe a new method, based on numerical modeling of mass spectra of metabolically labeled dolichols (Dols), designed to quantitatively follow the co-operation of the MVA and MEP reprogrammed upon osmotic stress (sorbitol treatment)...
April 6, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28385331/generalized-verrucosis-and-abnormal-t-cell-activation-due-to-homozygous-taok2-mutation
#13
Vered Molho-Pessach, Yuval Ramot, Maxim Mogilevsky, Leonor Cohen-Daniel, Eli M Eisenstein, Abdulsalam Abu-Libdeh, Ihab Siam, Michael Berger, Rotem Karni, Abraham Zlotogorski
BACKGROUND: Generalized verrucosis (GV) is a chronic and progressive cutaneous human papillomavirus (HPV) infection resulting in multiple warts and associated with acquired or genetic immune defects. We identified a consanguineous Arab family manifesting GV and recurrent bacterial and viral infections, in association with inflammatory bowel disease (IBD). OBJECTIVE: To identify the mutated gene responsible for GV, recurrent infections and IBD, in this family. METHODS: Flow cytometry of peripheral blood mononuclear cells was performed, as well as proliferation and cell cycle assays of T cells...
March 27, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28376141/viability-and-infectivity-of-tuber-borchii-after-cryopreservation
#14
F Piattoni, P Leonardi, B Siham, M Iotti, A Zambonelli
BACKGROUND: Truffles (Tuber spp.) are the most precious ectomycorrhizal edible mushrooms whose biodiversity is seriously endangered. OBJECTIVE: To develop a protocol for cryopreservation of Tuber spp. mycelia using T. borchii as a model species, verifying whether conservation in liquid nitrogen may affect viability, growth rate, hyphal morphology and infectivity. MATERIALS AND METHODS: Cryopreservation was performed using sorbitol, sucrose and DMSO as cryoprotectants...
January 2017: Cryo Letters
https://www.readbyqxmd.com/read/28375037/the-influence-of-stevia-on-the-flow-shear-and-compression-behavior-of-sorbitol-a-pharmaceutical-excipient-for-direct-compression
#15
Hana Hurychová, Pavel Ondrejček, Zdenka Šklubalová, Barbora Vraníková, Tomáš Svěrák
Good flow and compaction properties are necessary for manipulation of particulate material in the pharmaceutical industry. The influence of the addition of an alternative sweetener, rebaudioside A, in a concentration 0.2% w/w and 0.5% w/w on the flow, shear and compaction properties of sorbitol for direct compaction, Merisorb® 200, was investigated in this work. Rebaudioside A worsened the flow properties of sorbitol: the Hausner ratio, the compressibility index and the mass flow rate through the aperture of a model hopper...
April 4, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28374036/dependence-of-the-hydration-status-of-bacterial-light-harvesting-complex-2-on-polyol-cosolvents
#16
Ying Shi, Jie Yu, Long-Jiang Yu, Peng Wang, Li-Min Fu, Jian-Ping Zhang, Zheng-Yu Wang-Otomo
Low molecular weight (MW) polyols are organic osmolytes influencing protein structure and activity. We have intended to investigate the effects of low MW polyols on the optical and the excited-state properties of the light-harvesting complex 2 (LH2) isolated from the photosynthetic bacterium Thermochromatium (Tch.) tepidum, a thermophile growing at ∼50 °C. Steady state spectroscopy demonstrated that, on increasing glycerol or sorbitol fractions up to 60% (polyol/water, v/v), the visible absorption of carotenoids (Crts) remained unchanged, while the near infrared Qy absorption of bacteriochlorophyll a (BChl) at 800 nm (B800) and 850 nm (B850) varied slightly...
April 4, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28372462/polysaccharides-extraction-from-opuntia-stricta-and-their-protective-effect-against-hepg2-cell-death-and-hypolipidaemic-effects-on-hyperlipidaemia-rats-induced-by-high-fat-diet
#17
Bahira Harrabi, Khaled Athmouni, Latifa Hamdaoui, Lobna Ben Mahmoud, Ahmed Hakim, Abdelfattah El Feki, Khaled Zeghal, Hanéne Ghozzi
The aim of this study was to analyse cytoprotective effect of polysaccharides compound from Opuntia stricta (O. stricta) cladode (POS) in vitro including its radical scavenging activities and protective effects against hypercholesterolaemia. Our results showed that glucose was the dominant monosaccharides (30.35%). Arabinose, pyranose, fructose, galactose, glucose, sorbitol, S-inositol, M-inositol, trehalose and saccharose found in this species. O. stricta polysaccharides did not cause any cytotoxic effect on HepG2 cells within the range of concentrations tested (0-400 μgml(-1))...
April 3, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28370621/nitrate-dependent-shoot-sodium-accumulation-and-osmotic-functions-of-sodium-in-arabidopsis-under-saline-conditions
#18
Rocío Álvarez-Aragón, Alonso Rodríguez-Navarro
Improving crop plants to be productive in saline soils or under irrigation with saline water would be an important technological advance in overcoming the food and freshwater crises that threaten the world population. However, even if the transformation of a glycophyte into a plant that thrives under seawater irrigation were biologically feasible, current knowledge about Na(+) effects would be insufficient to support this technical advance. Intriguingly, crucial details about Na(+) uptake and its function in the plant have not yet been well established...
April 2, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28363147/renewable-energy-production-by-photoelectrochemical-oxidation-of-organic-wastes-using-wo3-photoanodes
#19
Dimitrios Raptis, Vassilios Dracopoulos, Panagiotis Lianos
The present work has studied renewable hydrogen production by photoelectrocatalytic degradation of model organic substances representing biomass derived organic wastes. Its purpose was to show that renewable energy can be produced by consuming wastes. The study has been carried out by employing nanoparticulate WO3 photoanodes in the presence of ethanol, glycerol or sorbitol, i.e. three substances which are among typical biomass products. In these substances, the molecular weight and the number of hydroxyl groups increases from ethanol to sorbitol...
March 22, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28358909/amelioration-of-cognitive-impairments-in-appswe-ps1de9-mice-is-associated-with-metabolites-alteration-induced-by-total-salvianolic-acid
#20
Li Shen, Bing Han, Yuan Geng, Jinhua Wang, Zhengmin Wang, Mingwei Wang
PURPOSE: Total salvianolic acid (TSA) is extracted from salvia miltiorrhiza; however, to date, there has been limited characterization of its effects on metabolites in Alzheimer's disease model-APPswe/PS1dE9 mice. The main objective of this study was to investigate the metabolic changes in 7-month-old APPswe/PS1dE9 mice treated with TSA, which protects against learning and memory impairment. METHODS: APPswe/PS1dE9 mice were treated with TSA (30 mg/kg·d and 60 mg/kg·d, i...
2017: PloS One
keyword
keyword
75060
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"