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Extreme premature and sever leukocytosis

Thomas R Bauer, Suzanne M Pratt, Christina M Palena, Karthik Raj, Urs Giger
BACKGROUND: Leukocyte adhesion deficiency (LAD) or CD18 deficiency is an autosomal recessive immunodeficiency which has been described in people, cattle, dogs, and knockout mice. OBJECTIVES: The study goals were to characterize the clinicopathologic, immunologic, and molecular genetic features of feline LAD (FLAD) in a neutered male adult Domestic Longhair cat with severe leukocytosis and recurrent infections. METHODS: Flow cytometry evaluated surface expression of CD18 on neutrophils...
September 2017: Veterinary Clinical Pathology
Manasi Kadam Ladrigan, Philip E LeBoit, Ilona J Frieden
We describe a 2-month-old preterm neonate presenting with neonatal eosinophilic pustulosis, manifesting as grouped pustules on the cheeks, leukocytosis and marked blood eosinophilia, and histology demonstrating abundant eosinophils without follicular involvement. Complete resolution of his skin lesions occurred spontaneously by 4 months of age, paralleling a decline in his eosinophil count. We discuss the relationship of this eruption to other pustular disorders of infancy and hypothesize a mechanism that may initiate the eruption...
January 2008: Pediatric Dermatology
Adam Reich, Jacek C Szepietowski, Eugeniusz Baran
A 23-year-old woman was admitted to the Department of Dermatology 4 days postpartum with multiple disseminated pustules. A week earlier, she had received 500 mg of amoxicillin with 125 mg clavulanic acid for pharyngitis. After three doses, she noticed the first pustules appear on the chest and back, and the antibiotic treatment was discontinued. Three days later, during the 37th gestational week, she delivered her second child prematurely, but in generally good condition. After delivery, her skin lesions began to spread, and the patient developed fever up to 39 degrees C (102...
July 2006: Skinmed
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