keyword
https://read.qxmd.com/read/38368072/rapid-eye-movement-sleep-behavior-disorder-management-and-prognostic-counseling
#21
REVIEW
Roneil Malkani
Management of rapid eye movement sleep behavior disorder (RBD) includes reducing injurious dream-enactment behaviors, risk of injury to self and bedpartner, and vivid or disruptive dreams and improving sleep quality and bedpartner sleep disruption. Safety precautions should be reviewed at each visit. Medications to reduce RBD symptoms such as melatonin, clonazepam, pramipexole, and rivastigmine should be considered for most patients. Isolated RBD confers a high lifetime risk of neurodegenerative diseases with a latency often spanning many years...
March 2024: Sleep Medicine Clinics
https://read.qxmd.com/read/38368071/rapid-eye-movement-sleep-behavior-disorder-clinical-presentation-and-diagnostic-criteria
#22
REVIEW
Brandon M Jones, Stuart J McCarter
Rapid eye movement (REM) sleep behavior disorder (RBD) classically presents with repetitive complex motor behavior during sleep with associated dream mentation. The diagnosis requires a history of repetitive complex motor behaviors and polysomnographic demonstration of REM sleep without atonia (RSWA) or capturing dream enactment behaviors. RSWA is best evaluated in the chin or flexor digitorum superficialis muscles. The anterior tibialis muscle is insufficiently accurate to be relied upon solely for RBD diagnosis...
March 2024: Sleep Medicine Clinics
https://read.qxmd.com/read/38368066/educational-resources-to-support-patients-with-parasomnias
#23
REVIEW
Courtney D Molina, Adreanne Rivera, Alon Y Avidan
This article serves to help reduce patient burden in searching for credible information about parasomnias-abnormal behaviors during sleep-including sleepwalking, night terrors, and rapid eye movement sleep behavior disorder. It exhibits a compiled list of accessible online resources about parasomnias as well as detailed descriptions about each resource. By increasing patient accessibility to clinically validated resources, patients are more empowered to take an active role in managing their conditions, collaborating with their health-care practitioners in clinical management, enrolling in registries, and joining newsletters sponsored by these resources...
March 2024: Sleep Medicine Clinics
https://read.qxmd.com/read/38367532/associations-of-sleep-related-variables-with-reverse-dipping-patterns-of-blood-pressure-in-%C3%AE-synucleinopathies
#24
JOURNAL ARTICLE
Yunchuang Sun, Luhua Wei, Fan Li, Chen Ling, Fei Zhai, Yunfeng Lv, Hong Zhou, Cheng Zhang, Jing Ma, Jing Chen, Wei Sun, Zhaoxia Wang
INTRODUCTION: The reverse dipping blood pressure (BP) pattern is very common in α-synucleinopathies. We aimed to explore the associations of sleep-related variables with abnormal BP circadian rhythms in Parkinson's disease (PD) and multiple system atrophy (MSA). METHODS: A total of 126 patients, 76 with PD and 50 with MSA, were included. All participants underwent ambulatory BP monitoring and full-night polysomnography (PSG). We analyzed abnormal dipping patterns and sleep-related parameters, including moderate to severe obstructive sleep apnea (OSA), rapid eye movement behavior disorder (RBD), average oxygen saturation (SaO2 %), lowest SaO2 %, duration of SaO2 % <90%, and apnea-hypopnea index (AHI)...
February 12, 2024: Parkinsonism & related Disorders
https://read.qxmd.com/read/38367357/slow-wave-sleep-and-rem-sleep-without-atonia-predict-motor-progression-in-parkinson-s-disease
#25
JOURNAL ARTICLE
Meng-Xing Tao, Lin Meng, Wei-Ye Xie, Han-Xing Li, Jin-Ru Zhang, Jia-Hui Yan, Xiao-Yu Cheng, Fen Wang, Cheng-Jie Mao, Yun Shen, Chun-Feng Liu
BACKGROUND: Growing evidence supports the potential role of sleep in the motor progression of Parkinson's disease (PD). Slow-wave sleep (SWS) and rapid eye movement (REM) sleep without atonia (RWA) are important sleep parameters. The association between SWS and RWA with PD motor progression and their predictive value have not yet been elucidated. METHODS: We retro-prospectively analyzed clinical and polysomnographic data of 136 patients with PD. The motor symptoms were assessed using Unified Parkinson's Disease Rating Scale Part III (UPDRS III) at baseline and follow-up to determine its progression...
February 8, 2024: Sleep Medicine
https://read.qxmd.com/read/38359614/extracellular-vesicles-contain-filamentous-alpha-synuclein-and-facilitate-the-propagation-of-parkinson-s-pathology
#26
JOURNAL ARTICLE
Yuta Ishiguro, Taiji Tsunnemi, Tomoyo Shimada, Asako Yoroisaka, Shin-Ichi Ueno, Haruka Takeshige-Amano, Taku Hatano, Yuichi Inoue, Shinji Saiki, Nobutaka Hattori
Parkinson's disease (PD) is characterized by the pathological deposition of a-synuclein (a-syn) inclusions, known as Lewy bodies/neurites. Emerging evidence suggests that extracellular vesicles (EVs) play a role in facilitating the spreading of Lewy pathology between the peripheral nervous system and the central nervous system. We analyzed serum EVs obtained from patients with PD (n = 142), multiple system atrophy (MSA) (n = 18), progressive supranuclear palsy (PSP) (n = 28), rapid eye movement sleep behavior disorder (n = 31), and controls (n = 105)...
February 2, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38341655/disclosing-the-risk-associated-with-isolated-rem-behavior-disorder-the-sleep-experts-perspective
#27
JOURNAL ARTICLE
Francesca Ingravallo, Alessandra D'Alterio, Andrea Rossetti, Elena Antelmi, Giuseppe Plazzi
BACKGROUND: Isolated rapid-eye-movement sleep behavior disorder (iRBD) is associated with a high risk for phenoconversion to a neurodegenerative disorder, but the optimal approach for disclosure of this risk to patients is still debated. OBJECTIVES: The aim of this study was to explore views and experiences of iRBD experts regarding risk disclosure. METHODS: In this qualitative study, semi-structured interviews with sleep experts caring for patients with iRBD were analyzed through a conventional content analysis approach...
February 11, 2024: Movement Disorders Clinical Practice
https://read.qxmd.com/read/38341229/macro-and-micro-sleep-dysfunctions-as-translational-biomarkers-for-parkinson-s-disease
#28
JOURNAL ARTICLE
Marcelo M S Lima, Adriano D S Targa, Gustavo Z Dos Santos Lima, Clarissa F Cavarsan, Pablo Torterolo
Sleep disturbances are highly prevalent among patients with Parkinson's disease (PD) and often appear from the early-phase disease or prodromal stages. In this chapter, we will discuss the current evidence addressing the links between sleep dysfunctions in PD, focusing most closely on those data from animal and mathematical/computational models, as well as in human-based studies that explore the electrophysiological and molecular mechanisms by which PD and sleep may be intertwined, whether as predictors or consequences of the disease...
2024: International Review of Neurobiology
https://read.qxmd.com/read/38340219/clinical-features-disease-progression-and-nuclear-imaging-in-atxn2-related-parkinsonism-in-a-longitudinal-cohort
#29
JOURNAL ARTICLE
Yi-Dan Xu, Xin-Yue Zhou, Si-Di Wei, Feng-Tao Liu, Jue Zhao, Yi-Lin Tang, Bo Shen, Zheng-Tong Ding, Jian-Jun Wu, Yi-Min Sun, Jian Wang
BACKGROUND: Spinocerebellar ataxia 2 (SCA2) with a low range of CAG repeat expansion of ATXN2 gene can present with predominant or isolated parkinsonism that closely resembles Parkinson's disease (PD). This study is aimed at comparing clinical features, disease progression, and nuclear imaging between ATXN2-related parkinsonism (ATXN2-P) and PD. METHODS: Three hundred and seventy-seven clinically diagnosed PD with family history were screened by multiplex ligation-dependent probe amplification, whole-exome sequencing or target sequencing, and dynamic mutation testing of 10 SCA subtypes...
February 10, 2024: Neurological Sciences
https://read.qxmd.com/read/38337608/gender-difference-in-rem-sleep-behavior-disorder-in-japanese-population-polysomnography-and-sleep-questionnaire-study
#30
JOURNAL ARTICLE
Mamiko Mano, Atsuhiko Nomura, Ryujiro Sasanabe
Rapid eye movement (REM) sleep behavior disorder (RBD) is generally common among males and is an established risk factor for neurodegenerative diseases. As the population ages, the prevalence of α-synucleinopathy (such as Parkinson's disease) is increasing. Additionally, the number of female patients is increasing in Japan. Therefore, we aimed to clarify the clinical characteristics of RBD from the perspective of gender differences in the Japanese population. The proportion of male RBD patients (65.2%) was significantly higher than that of female patients (34...
February 5, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38330231/eeg-based-machine-learning-models-for-the-prediction-of-phenoconversion-time-and-subtype-in-irbd
#31
JOURNAL ARTICLE
El Jeong, Yong Woo Shin, Jung-Ick Byun, Jun-Sang Sunwoo, Monica Roascio, Pietro Mattioli, Laura Giorgetti, Francesco Famà, Gabriele Arnulfo, Dario Arnaldi, Han-Joon Kim, Ki-Young Jung
STUDY OBJECTIVES: Idiopathic/Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal stage of α-synucleinopathies and eventually phenoconverts to overt neurodegenerative diseases including Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). Associations of baseline resting-state electroencephalography (EEG) with phenoconversion have been reported. In this study, we aimed to develop machine learning models to predict phenoconversion time and subtype using baseline EEG features in patients with iRBD...
February 8, 2024: Sleep
https://read.qxmd.com/read/38325344/associations-between-sleep-disorders-and-impulsive-compulsive-behaviors-in-parkinson-s-disease-a-prospective-cohort-study
#32
JOURNAL ARTICLE
Meijie Ye, Xiaoying Kang, Ida K Karlsson, Yu Wang, Qianqian Ji, Qi Liu, Xiaowei Xu, Sara Hägg, Fang Fang, Karin Wirdefeldt, Yiqiang Zhan
OBJECTIVE: To examine the associations of excessive daytime sleepiness (EDS) and probable rapid eye movement sleep behavior disorder (pRBD), respectively, with impulsive-compulsive behaviors (ICB) over a 5-year follow-up in patients with early Parkinson's disease (PD). METHODS: The Parkinson's Progression Markers Initiative is a multicenter cohort study based on an ongoing and open-ended registry. Longitudinal associations of sleep disorders with ICB over 5-year follow-up visits were estimated using generalized linear mixed-effects models among PD participants...
February 7, 2024: Neuroepidemiology
https://read.qxmd.com/read/38315966/-99m-tc-hmpao-spect-perfusion-signatures-associated-with-clinical-progression-in-patients-with-isolated-rem-sleep-behavior-disorder
#33
JOURNAL ARTICLE
Shady Rahayel, Ronald Postuma, Andrée-Ann Baril, Bratislav Misic, Amélie Pelletier, Jean-Paul Soucy, Jacques Montplaisir, Alain Dagher, Jean-François Gagnon
BACKGROUND AND OBJECTIVES: Idiopathic/isolated REM sleep behavior disorder (iRBD) is associated with dementia with Lewy bodies and Parkinson disease. Despite evidence of abnormal cerebral perfusion in iRBD, there is currently no pattern that can predict whether an individual will develop dementia with Lewy bodies or Parkinson disease. The objective was to identify a perfusion signature associated with conversion to dementia with Lewy bodies in iRBD. METHODS: Patients with iRBD underwent video-polysomnography, neurologic and neuropsychological assessments, and baseline 99m Tc-HMPAO SPECT to assess relative cerebral blood flow...
February 2024: Neurology
https://read.qxmd.com/read/38313757/masseter-vestibular-evoked-myogenic-potentials-a-new-tool-to-assess-the-vestibulomasseteric-reflex-pathway
#34
REVIEW
Aishwarya Nagarajan, Sujeet Kumar Sinha
PURPOSE: This review article provides the readers with an in-depth insight in understanding and interpreting various research literatures on the masseter vestibular evoked myogenic potentials (mVEMP). The article also reviews the contemporary researches involving the clinical applications of the mVEMP. CONCLUSIONS: Masseter VEMP is an evolving yet clinically promising neuro-otology test tool that has recently gained more research interest and is considered an additional tool to diagnose various vestibular disorders...
January 2024: Journal of Otology
https://read.qxmd.com/read/38295625/functional-connectivity-based-classification-of-rapid-eye-movement-sleep-behavior-disorder
#35
JOURNAL ARTICLE
Toma Matsushima, Kenji Yoshinaga, Noritaka Wakasugi, Hiroki Togo, Takashi Hanakawa
BACKGROUND: Isolated rapid eye movement sleep behavior disorder (iRBD) is a clinically important parasomnia syndrome preceding α-synucleinopathies, thereby prompting us to develop methods for evaluating latent brain states in iRBD. Resting-state functional magnetic resonance imaging combined with a machine learning-based classification technology may help us achieve this purpose. METHODS: We developed a machine learning-based classifier using functional connectivity to classify 55 patients with iRBD and 97 healthy elderly controls (HC)...
January 22, 2024: Sleep Medicine
https://read.qxmd.com/read/38295508/comparison-of-quantitative-rem-without-atonia-parameters-in-isolated-rem-sleep-behavior-disorder-and-early-untreated-parkinson-s-disease
#36
JOURNAL ARTICLE
Pavla Perinova, Jiri Nepozitek, Simona Dostalova, Ondrej Bezdicek, Evzen Ruzicka, Petr Dusek, Karel Sonka
OBJECTIVES: To analyze REM sleep without atonia (RWA) metrics in patients with isolated REM sleep behavior disorder (iRBD), Parkinson's disease (PD) and healthy subjects and compare them in terms of degree of presumed brainstem damage. METHODS: Forty-nine iRBD patients, 62 PD patients and 38 healthy controls were included into the analysis. Detailed polysomnographic and clinical data including motor, olfactory, autonomic, and cognitive assessment were obtained in all participants and subsequently compared within groups without RBD (i...
February 2024: Sleep Medicine
https://read.qxmd.com/read/38289245/risk-stratification-for-phenoconversion-in-patients-with-isolated-rem-sleep-behavior-disorder-a-follow-up-study-from-turkey
#37
JOURNAL ARTICLE
G Benbir-Senel, N Albayrak, I Yanik, E Gokcen-Polat, C H Schenck, D Karadeniz
INTRODUCTION: Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is one of the strongest prodromal markers of alpha-synucleinopathies. We aimed to investigate non-invasive clinical and quantitative predictors of phenoconversion from iRBD to parkinsonism. PATIENTS AND METHODS: We prospectively followed-up a total of 45 patients (57.8% men) for eight years. Clinical assessments, Sniffin' Sticks Odor Identification Test, Farnsworth-Munsell 100 Hue Color Vision test, Beck Depression Inventory and Rome III Criteria for constipation were performed...
February 1, 2024: Revista de Neurologia
https://read.qxmd.com/read/38279053/%C3%AE-synuclein-reduces-acetylserotonin-o-methyltransferase-mediated-melatonin-biosynthesis-by-microtubule-associated-protein-1-light-chain-3-beta-related-degradation-pathway
#38
JOURNAL ARTICLE
Congcong Jia, Lulu Tian, Cheng Cheng, Jun Zhang, Murad Al-Nusaif, Tianbai Li, Huijia Yang, Yushan Lin, Song Li, Weidong Le
Previous studies have demonstrated that α-synuclein (α-SYN) is closely associated with rapid eye movement sleep behavior disorder (RBD) related to several neurodegenerative disorders. However, the exact molecular mechanisms are still rarely investigated. In the present study, we found that in the α-SYNA53T induced RBD-like behavior mouse model, the melatonin level in the plasma and pineal gland were significantly decreased. To elucidate the underlying mechanism of α-SYN-induced melatonin reduction, we investigated the effect of α-SYN in melatonin biosynthesis...
January 27, 2024: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/38277299/under-diagnosis-of-dementia-with-lewy-bodies-in-individuals-racialized-as-black-hypotheses-regarding-potential-contributors
#39
REVIEW
Melissa J Armstrong, Lisa L Barnes
Dementia with Lewy bodies (DLB) is one of the most common degenerative dementias after Alzheimer's disease (AD) dementia. DLB is under-diagnosed across populations but may be particularly missed in older Black adults. The object of this review was to examine key features of DLB and potential associations with race in order to hypothesize why DLB may be under-diagnosed in Black adults in the U.S. In terms of dementia, symptoms associated with high rates of co-pathology (e.g., AD, vascular disease) in older Black adults may obscure the clinical picture that might suggest Lewy body pathology...
January 24, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38271662/montreal-cognitive-assessment-and-the-clock-drawing-test-to-identify-mci-and-predict-dementia-in-isolated-rem-sleep-behavior-disorder
#40
JOURNAL ARTICLE
Émile Cogné, Ronald B Postuma, Marie-Joëlle Chasles, Jessie De Roy, Jacques Montplaisir, Amélie Pelletier, Isabelle Rouleau, Jean-François Gagnon
BACKGROUND AND OBJECTIVES: Patients with isolated/idiopathic REM sleep behavior disorder (iRBD) are at high risk for developing mild cognitive impairment (MCI) and dementia with Lewy bodies (DLB). However, there is a lack of scientific knowledge regarding the accuracy of cognitive screening tools to identify these conditions in iRBD. This study aimed to determine in iRBD the psychometrics of 2 screening tests to discriminate patients with MCI and those at risk of DLB. METHODS: We retrospectively selected and followed 64 patients with polysomnography-confirmed iRBD seen in sleep clinic between 2006 and 2021, 32 with MCI (mean age 68...
February 27, 2024: Neurology
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