keyword
https://read.qxmd.com/read/38529776/alterations-of-peripheral-lymphocyte-subsets-in-isolated-rapid-eye-movement-sleep-behavior-disorder
#1
JOURNAL ARTICLE
Yuanchu Zheng, Yatong Li, Huihui Cai, Wenyi Kou, Chen Yang, Siming Li, Jiawei Wang, Ning Zhang, Tao Feng
BACKGROUND: Adaptive immune dysfunction may play a crucial role in Parkinson's disease (PD) development. Isolated rapid eye movement sleep behavior disorder (iRBD) represents the prodromal stage of synucleinopathies, including PD. Elucidating the peripheral adaptive immune system is crucial in iRBD, but current knowledge remains limited. OBJECTIVE: This study aimed to characterize peripheral lymphocyte profiles in iRBD patients compared with healthy control subjects (HCs)...
March 26, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/38520943/quantifying-cerebral-blood-flow-changes-using-arterial-spin-labeling-a-comparative-study-of-idiopathic-rapid-eye-movement-sleep-behavior-disorder-and-parkinson-s-disease
#2
JOURNAL ARTICLE
Yuqi Zhi, Mingshen Chen, Chunshan Zhou, Yongxu Yang, Yan Huang, Xiaoyun Liang, Ping Wang, Xiaoyu Cheng, Chengjie Mao, Zhen Jiang, Yakang Dai, Bo Peng, Jiangtao Zhu
INTRODUCTION: Idiopathic rapid eye movement sleep behavior disorder (iRBD) and Parkinson's disease (PD) have been found to have changes in cerebral perfusion and overlap of some of the lesioned brain areas. However, a consensus regarding the specific location and diagnostic significance of these cerebral blood perfusion alternations remains elusive in both iRBD and PD. The present study evaluated the patterns of cerebral blood flow changes in iRBD and PD. MATERIAL AND METHODS: A total of 59 right-handed subjects were enrolled, including 15 patients with iRBD, 20 patients with PD, and 24 healthy controls (HC)...
March 22, 2024: Magnetic Resonance Imaging
https://read.qxmd.com/read/38519273/brain-first-vs-body-first-parkinson-s-disease-an-update-on-recent-evidence
#3
REVIEW
Jacob Horsager, Per Borghammer
We recently proposed a new disease model of Parkinson's disease - the a-Synuclein Origin site and Connectome model. The model posits that the initial pathology starts either in the olfactory bulb or amygdala leading to a brain-first subtype, or in the enteric nervous system leading to a body-first subtype. These subtypes should be distinguishable early in the disease course on a range of imaging, clinical, and neuropathological markers. Here, we review recent original human studies, which tested the predictions of the model...
March 15, 2024: Parkinsonism & related Disorders
https://read.qxmd.com/read/38517805/opportunities-and-pitfalls-of-rem-sleep-behavior-disorder-and-olfactory-dysfunction-as-early-markers-in-parkinson-s-disease
#4
REVIEW
Beatrice Orso, Sarah Brosse, Johannes Frasnelli, Dario Arnaldi
During its pre-motor stage, Parkinson's disease (PD) presents itself with a multitude of non-motor symptoms with different degrees of specificity and sensitivity. The most important among them are REM sleep behavior disorder (RBD) and olfactory dysfunction. RBD is a parasomnia characterized by the loss of REM sleep muscle atonia and dream-enacting behaviors. Olfactory dysfunction in individuals with prodromal PD is usually described as hyposmia (reduced sense of smell) or anosmia (complete loss of olfactory function)...
March 22, 2024: Journal of Parkinson's Disease
https://read.qxmd.com/read/38502973/mitochondrial-dna-deletions-in-the-cerebrospinal-fluid-of-patients-with-idiopathic-rem-sleep-behaviour-disorder
#5
JOURNAL ARTICLE
Margalida Puigròs, Anna Calderon, Daniel Martín-Ruiz, Mònica Serradell, Manel Fernández, Amaia Muñoz-Lopetegi, Gerard Mayà, Joan Santamaria, Carles Gaig, Anna Colell, Eduard Tolosa, Alex Iranzo, Ramon Trullas
BACKGROUND: Idiopathic rapid eye movement (REM) sleep behaviour disorder (IRBD) represents the prodromal stage of Lewy body disorders (Parkinson's disease (PD) and dementia with Lewy bodies (DLB)) which are linked to variations in circulating cell-free mitochondrial DNA (cf-mtDNA). Here, we assessed whether altered cf-mtDNA release and integrity are already present in IRBD. METHODS: We used multiplex digital PCR (dPCR) to quantify cf-mtDNA copies and deletion ratio in cerebrospinal fluid (CSF) and serum in a cohort of 71 participants, including 1) 17 patients with IRBD who remained disease-free (non-converters), 2) 34 patients initially diagnosed with IRBD who later developed either PD or DLB (converters), and 3) 20 age-matched controls without IRBD or Parkinsonism...
March 18, 2024: EBioMedicine
https://read.qxmd.com/read/38499543/turning-alterations-detected-by-mobile-health-technology-in-idiopathic-rem-sleep-behavior-disorder
#6
JOURNAL ARTICLE
Cinzia Zatti, Andrea Pilotto, Clint Hansen, Andrea Rizzardi, Marcello Catania, Robbin Romijnders, Leandro Purin, Maria P Pasolini, Eva Schaeffer, Andrea Galbiati, Luigi Ferini-Strambi, Daniela Berg, Walter Maetzler, Alessandro Padovani
Idiopathic REM sleep Behavior Disorder (iRBD) is a condition at high risk of developing Parkinson's disease (PD) and other alpha-synucleinopathies. The aim of the study was to evaluate subtle turning alterations by using Mobile health technology in iRBD individuals without subthreshold parkinsonism. A total of 148 participants (23 persons with polysomnography-confirmed iRBD without subthreshold parkinsonism, 60 drug-naïve PD patients, and 65 age-matched controls were included in this prospective cross-sectional study...
March 18, 2024: NPJ Parkinson's Disease
https://read.qxmd.com/read/38497896/eeg-rhythmic-and-arrhythmic-spectral-components-and-functional-connectivity-at-resting-state-may-predict-the-development-of-synucleinopathies-in-idiopathic-rem-sleep-behavior-disorder
#7
JOURNAL ARTICLE
J Hernandez, J-M Lina, J Dubé, A Lafrenière, J-F Gagnon, J-Y Montplaisir, R B Postuma, J Carrier
STUDY OBJECTIVES: Idiopathic/isolated REM-sleep behavior disorder (iRBD) often precedes the onset of synucleinopathies. Here, we investigated whether baseline resting-state EEG advanced spectral power and functional connectivity differ between iRBD patients who converted towards a synucleinopathy at follow-up and those who did not. METHODS: Eighty-one participants with iRBD (66.89±6.91 years) underwent a baseline resting-state EEG recording, a neuropsychological assessment and a neurological examination...
March 18, 2024: Sleep
https://read.qxmd.com/read/38494747/rapid-eye-movement-sleep-behavior-disorder-and-its-relation-to-parkinson-s-disease-the-potential-of-graph-measures-as-brain-biomarkers-to-identify-the-underlying-physiopathology-of-the-disorder
#8
REVIEW
Milad Najafzadeh, Fatemeh Mohammadian, Sara Mirabian, Zohre Ganji, Hossein Akbari, Masoud Rezaie, Esmaeil Ranjbar, Hoda Zare, Shahrokh Nasseri, Luigi Ferini-Strambi
Rapid eye movement behavior disorder (RBD) is a parasomnia characterized by the loss of skeletal muscle atonia during the rapid eye movement (REM) sleep phase. On the other hand, idiopathic RDB (iRBD) is considered the prelude of the various α-synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy. Consequently, over 40% of patients eventually develop PD. Recent neuroimaging studies utilizing structural magnetic resonance imaging (s-MRI), diffusion-weighted imaging (DWI), and functional magnetic resonance imaging (fMRI) with graph theoretical analysis have demonstrated that patients with iRBD and Parkinson's disease have extensive brain abnormalities...
March 2024: Brain and Behavior
https://read.qxmd.com/read/38491789/sleep-disorders-cause-parkinson-s-disease-or-the-reverse-is-true-good-gaba-good-night
#9
REVIEW
Hayder M Al-Kuraishy, Ali I Al-Gareeb, Ali K Albuhadily, Yaser Hosny Ali Elewa, Ammar Al-Farga, Faisal Aqlan, Mahmoud Hosny Zahran, Gaber El-Saber Batiha
BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative brain disease due to degeneration of dopaminergic neurons (DNs) presented with motor and non-motor symptoms. PD symptoms are developed in response to the disturbance of diverse neurotransmitters including γ-aminobutyric acid (GABA). GABA has a neuroprotective effect against PD neuropathology by protecting DNs in the substantia nigra pars compacta (SNpc). It has been shown that the degeneration of GABAergic neurons is linked with the degeneration of DNs and the progression of motor and non-motor PD symptoms...
March 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38489578/free-water-imaging-of-the-nucleus-basalis-of-meynert-in-patients-with-idiopathic-rem-sleep-behavior-disorder-and-parkinson-disease
#10
JOURNAL ARTICLE
Dongling Zhang, Liche Zhou, Chenxi Lu, Tao Feng, Jun Liu, Tao Wu
BACKGROUND AND OBJECTIVES: Cognitive impairments are common in idiopathic REM sleep behavior disorder (iRBD), in which the cholinergic degeneration of nucleus basalis of Meynert (NBM) may play an important role. However, the progressive changes of NBM, the relationship between progressive NBM degeneration and progression of cognitive impairments, and whether degeneration of the NBM can predict cognitive decline in patients with iRBD remain unclear. This study aimed to investigate the cross-sectional and longitudinal microstructural alterations in the NBM of patients with iRBD using free-water imaging and whether free water in the NBM is related to cognitive, mood, and autonomic function...
April 9, 2024: Neurology
https://read.qxmd.com/read/38489198/perspectives-of-people-at-risk-on-parkinson-s-prevention-research
#11
REVIEW
Jessi L Keavney, Soania Mathur, Karlin Schroeder, Ray Merrell, Sergio A Castillo-Torres, Virginia Gao, Grace F Crotty, Michael A Schwarzschild, John M Poma
 The movement toward prevention trials in people at-risk for Parkinson's disease (PD) is rapidly becoming a reality. The authors of this article include a genetically at-risk advocate with the LRRK2 G2019 S variant and two patients with rapid eye movement sleep behavior disorder (RBD), one of whom has now been diagnosed with PD. These authors participated as speakers, panelists, and moderators in the "Planning for Prevention of Parkinson's: A Trial Design Forum" hosted by Massachusetts General Hospital in 2021 and 2022...
March 14, 2024: Journal of Parkinson's Disease
https://read.qxmd.com/read/38482885/eeg-spectro-spatial-covariance-patterns-related-to-phenoconversion-in-isolated-rem-sleep-behavior-disorder-and-their-longitudinal-trajectories-in-%C3%AE-synucleinopathies
#12
JOURNAL ARTICLE
Kyoungeun Park, Jung Hwan Shin, Jung-Ick Byun, El Jeong, Han-Joon Kim, Ki-Young Jung
STUDY OBJECTIVES: This study aimed to identify electroencephalographic (EEG) spectro-spatial covariance patterns associated with phenoconversion in isolated rapid eye movement sleep behavior disorder (iRBD) patients and explore their longitudinal trajectories within α-synucleinopathies. METHODS: We assessed 47 participants, including 35 iRBD patients and 12 healthy controls (HC), through baseline eye-closed resting EEGs. iRBD patients underwent follow-up EEG assessments and 18 iRBD patients converted (12 to Parkinson's disease (PD), 6 to dementia with Lewy bodies (DLB)) during follow-up...
March 14, 2024: Sleep
https://read.qxmd.com/read/38479482/microstructural-alterations-of-the-hypothalamus-in-parkinson-s-disease-and-probable-rem-sleep-behavior-disorder
#13
JOURNAL ARTICLE
Cheng Zhou, Jia You, Xiaojun Guan, Tao Guo, Jingjing Wu, Haoting Wu, Chenqing Wu, Jingwen Chen, Jiaqi Wen, Sijia Tan, Xioajie Duanmu, Jianmei Qin, Peiyu Huang, Baorong Zhang, Wei Cheng, Jianfeng Feng, Xiaojun Xu, Linbo Wang, Minming Zhang
BACKGROUND: Whether there is hypothalamic degeneration in Parkinson's disease (PD) and its association with clinical symptoms and pathophysiological changes remains controversial. OBJECTIVES: We aimed to quantify microstructural changes in hypothalamus using a novel deep learning-based tool in patients with PD and those with probable rapid-eye-movement sleep behavior disorder (pRBD). We further assessed whether these microstructural changes associated with clinical symptoms and free thyroxine (FT4) levels...
March 11, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38477376/microglial-activation-and-progression-of-nigrostriatal-dysfunction-in-isolated-rem-sleep-behavior-disorder
#14
JOURNAL ARTICLE
Kristian Staer, Alex Iranzo, Morten Gersel Stokholm, Victor S Hvingelby, Erik Hvid Danielsen, Karen Østergaard, Mónica Serradell, Marit Otto, Kristina B Svendsen, Alicia Garrido, Dolores Vilas, Joan Santamaria, Arne Møller, Carles Gaig, David J Brooks, Per Borghammer, Eduardo Tolosa, Nicola Pavese
BACKGROUND: Using 11 C-(R)-PK11195-PET, we found increased microglia activation in isolated REM sleep behavior disorder (iRBD) patients. Their role remains to be clarified. OBJECTIVES: The objective is to assess relationships between activated microglia and progression of nigrostriatal dysfunction in iRBD. METHODS: Fifteen iRBD patients previously scanned with 11 C-(R)-PK11195 and 18 F-DOPA-PET underwent repeat 18 F-DOPA-PET after 3 years...
March 13, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/38470080/the-motor-dysfunction-seen-in-isolated-rem-sleep-behavior-disorder
#15
JOURNAL ARTICLE
Cristina Simonet, Laura Pérez-Carbonell, Miquel A Galmés-Ordinas, Brook F R Huxford, Harneek Chohan, Aneet Gill, Guy Leschziner, Andrew J Lees, Anette Schrag, Alastair J Noyce
BACKGROUND: Isolated Rapid Eye Movement (REM) sleep Behavior Disorder (iRBD) requires quantitative tools to detect incipient Parkinson's disease (PD). METHODS: A motor battery was designed and compared with the Movement Disorder Society-Unified Parkinson's Disease Rating Scale part III (MDS-UPDRS-III) in people with iRBD and controls. This included two keyboard-based tests (BRadykinesia Akinesia INcoordination tap test and Distal Finger Tapping) and two dual tasking tests (walking and finger tapping)...
March 12, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/38467937/comprehensive-proteomics-of-csf-plasma-and-urine-identify-ddc-and-other-biomarkers-of-early-parkinson-s-disease
#16
JOURNAL ARTICLE
Jarod Rutledge, Benoit Lehallier, Pardis Zarifkar, Patricia Moran Losada, Marian Shahid-Besanti, Dan Western, Priyanka Gorijala, Sephira Ryman, Maya Yutsis, Gayle K Deutsch, Elizabeth Mormino, Alexandra Trelle, Anthony D Wagner, Geoffrey A Kerchner, Lu Tian, Carlos Cruchaga, Victor W Henderson, Thomas J Montine, Per Borghammer, Tony Wyss-Coray, Kathleen L Poston
Parkinson's disease (PD) starts at the molecular and cellular level long before motor symptoms appear, yet there are no early-stage molecular biomarkers for diagnosis, prognosis prediction, or monitoring therapeutic response. This lack of biomarkers greatly impedes patient care and translational research-L-DOPA remains the standard of care more than 50 years after its introduction. Here, we performed a large-scale, multi-tissue, and multi-platform proteomics study to identify new biomarkers for early diagnosis and disease monitoring in PD...
March 11, 2024: Acta Neuropathologica
https://read.qxmd.com/read/38466158/presynaptic-dopaminergic-imaging-characterizes-patients-with-rem-sleep-behavior-disorder-due-to-synucleinopathy
#17
JOURNAL ARTICLE
Dario Arnaldi, Pietro Mattioli, Stefano Raffa, Matteo Pardini, Federico Massa, Alex Iranzo, Andres Perissinotti, Aida Niñerola-Baizán, Carles Gaig, Monica Serradell, Amaia Muñoz-Lopetegi, Gerard Mayà, Claudio Liguori, Mariana Fernandes, Fabio Placidi, Agostino Chiaravalloti, Karel Šonka, Petr Dušek, David Zogala, Jiri Trnka, Bradley F Boeve, Toji Miyagawa, Val J Lowe, Tomoyuki Miyamoto, Masayuki Miyamoto, Monica Puligheddu, Michela Figorilli, Alessandra Serra, Michele T Hu, Johannes C Klein, Frederik Bes, Dieter Kunz, Valérie Cochen De Cock, Delphine de Verbizier, Giuseppe Plazzi, Elena Antelmi, Michele Terzaghi, Irene Bossert, Kristína Kulcsárová, Alessio Martino, Alessandro Giuliani, Marco Pagani, Flavio Nobili, Silvia Morbelli
OBJECTIVE: To apply a machine learning analysis to clinical and presynaptic dopaminergic imaging data of patients with rapid eye movement (REM) sleep behavior disorder (RBD) to predict the development of Parkinson disease (PD) and dementia with Lewy bodies (DLB). METHODS: In this multicenter study of the International RBD study group, 173 patients (mean age 70.5 ± 6.3 years, 70.5% males) with polysomnography-confirmed RBD who eventually phenoconverted to overt alpha-synucleinopathy (RBD due to synucleinopathy) were enrolled, and underwent baseline presynaptic dopaminergic imaging and clinical assessment, including motor, cognitive, olfaction, and constipation evaluation...
March 11, 2024: Annals of Neurology
https://read.qxmd.com/read/38456361/cortical-macro-and-microstructural-changes-in-parkinson-s-disease-with-probable-rapid-eye-movement-sleep-behavior-disorder
#18
JOURNAL ARTICLE
Jèssica Pardo, Victor Montal, Anna Campabadal, Javier Oltra, Carme Uribe, Ignacio Roura, Núria Bargalló, Maria J Martí, Yaroslau Compta, Alex Iranzo, Juan Fortea, Carme Junqué, Bàrbara Segura
BACKGROUND: Evidence regarding cortical atrophy patterns in Parkinson's disease (PD) with probable rapid eye movement sleep behavior disorder (RBD) (PD-pRBD) remains scarce. Cortical mean diffusivity (cMD), as a novel imaging biomarker highly sensitive to detecting cortical microstructural changes in different neurodegenerative diseases, has not been investigated in PD-pRBD yet. OBJECTIVES: The aim was to investigate cMD as a sensitive measure to identify subtle cortical microstructural changes in PD-pRBD and its relationship with cortical thickness (CTh)...
March 8, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/38443213/melanopsin-retinal-ganglion-cell-function-in-alzheimer-s-vs-parkinson-s-disease-an-exploratory-meta-analysis-and-review-of-pupillometry-protocols
#19
REVIEW
Oliver Leopold Steiner, Jan de Zeeuw
BACKGROUND: Neurodegenerative diseases share retinal abnormalities. Chromatic pupillometry allows in vivo assessment of photoreceptor functional integrity, including melanopsin-expressing retinal ganglion cells. This exploratory meta-analysis assesses retinal photoreceptor functionality in Alzheimer's vs. Parkinson's disease and conducts an in-depth review of applied pupillometric protocols. METHODS: Literature reviews on PubMed and Scopus from 1991 to August 2023 identified chromatic pupillometry studies on Alzheimer's disease (AD; n = 42 patients from 2 studies) and Parkinson's disease (PD; n = 66 from 3 studies)...
February 27, 2024: Parkinsonism & related Disorders
https://read.qxmd.com/read/38437860/cholinergic-changes-in-lewy-body-disease-implications-for-presentation-progression-and-subtypes
#20
JOURNAL ARTICLE
Niels Okkels, Michel J Grothe, John-Paul Taylor, Steen Gregers Hasselbalch, Tatyana D Fedorova, Karoline Knudsen, Sygrid van der Zee, Teus van Laar, Nicolaas Bohnen, Per Borghammer, Jacob Horsager
Cholinergic degeneration is significant in Lewy body disease, including Parkinson's disease, dementia with Lewy bodies, and isolated REM sleep behavior disorder. Extensive research has demonstrated cholinergic alterations in the central nervous system of these disorders. More recently, studies have revealed cholinergic denervation in organs that receive parasympathetic denervation. This enables a comprehensive review of cholinergic changes in Lewy body disease, encompassing both central and peripheral regions, various disease stages, and diagnostic categories...
March 4, 2024: Brain
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