keyword
https://read.qxmd.com/read/38491789/sleep-disorders-cause-parkinson-s-disease-or-the-reverse-is-true-good-gaba-good-night
#1
REVIEW
Hayder M Al-Kuraishy, Ali I Al-Gareeb, Ali K Albuhadily, Yaser Hosny Ali Elewa, Ammar Al-Farga, Faisal Aqlan, Mahmoud Hosny Zahran, Gaber El-Saber Batiha
BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative brain disease due to degeneration of dopaminergic neurons (DNs) presented with motor and non-motor symptoms. PD symptoms are developed in response to the disturbance of diverse neurotransmitters including γ-aminobutyric acid (GABA). GABA has a neuroprotective effect against PD neuropathology by protecting DNs in the substantia nigra pars compacta (SNpc). It has been shown that the degeneration of GABAergic neurons is linked with the degeneration of DNs and the progression of motor and non-motor PD symptoms...
March 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38489578/free-water-imaging-of-the-nucleus-basalis-of-meynert-in-patients-with-idiopathic-rem-sleep-behavior-disorder-and-parkinson-disease
#2
JOURNAL ARTICLE
Dongling Zhang, Liche Zhou, Chenxi Lu, Tao Feng, Jun Liu, Tao Wu
BACKGROUND AND OBJECTIVES: Cognitive impairments are common in idiopathic REM sleep behavior disorder (iRBD), in which the cholinergic degeneration of nucleus basalis of Meynert (NBM) may play an important role. However, the progressive changes of NBM, the relationship between progressive NBM degeneration and progression of cognitive impairments, and whether degeneration of the NBM can predict cognitive decline in patients with iRBD remain unclear. This study aimed to investigate the cross-sectional and longitudinal microstructural alterations in the NBM of patients with iRBD using free-water imaging and whether free water in the NBM is related to cognitive, mood, and autonomic function...
April 9, 2024: Neurology
https://read.qxmd.com/read/38489198/perspectives-of-people-at-risk-on-parkinson-s-prevention-research
#3
REVIEW
Jessi L Keavney, Soania Mathur, Karlin Schroeder, Ray Merrell, Sergio A Castillo-Torres, Virginia Gao, Grace F Crotty, Michael A Schwarzschild, John M Poma
 The movement toward prevention trials in people at-risk for Parkinson's disease (PD) is rapidly becoming a reality. The authors of this article include a genetically at-risk advocate with the LRRK2 G2019 S variant and two patients with rapid eye movement sleep behavior disorder (RBD), one of whom has now been diagnosed with PD. These authors participated as speakers, panelists, and moderators in the "Planning for Prevention of Parkinson's: A Trial Design Forum" hosted by Massachusetts General Hospital in 2021 and 2022...
March 14, 2024: Journal of Parkinson's Disease
https://read.qxmd.com/read/38482885/eeg-spectro-spatial-covariance-patterns-related-to-phenoconversion-in-isolated-rem-sleep-behavior-disorder-and-their-longitudinal-trajectories-in-%C3%AE-synucleinopathies
#4
JOURNAL ARTICLE
Kyoungeun Park, Jung Hwan Shin, Jung-Ick Byun, El Jeong, Han-Joon Kim, Ki-Young Jung
STUDY OBJECTIVES: This study aimed to identify electroencephalographic (EEG) spectro-spatial covariance patterns associated with phenoconversion in isolated rapid eye movement sleep behavior disorder (iRBD) patients and explore their longitudinal trajectories within α-synucleinopathies. METHODS: We assessed 47 participants, including 35 iRBD patients and 12 healthy controls (HC), through baseline eye-closed resting EEGs. iRBD patients underwent follow-up EEG assessments and 18 iRBD patients converted (12 to Parkinson's disease (PD), 6 to dementia with Lewy bodies (DLB)) during follow-up...
March 14, 2024: Sleep
https://read.qxmd.com/read/38479482/microstructural-alterations-of-the-hypothalamus-in-parkinson-s-disease-and-probable-rem-sleep-behavior-disorder
#5
JOURNAL ARTICLE
Cheng Zhou, Jia You, Xiaojun Guan, Tao Guo, Jingjing Wu, Haoting Wu, Chenqing Wu, Jingwen Chen, Jiaqi Wen, Sijia Tan, Xioajie Duanmu, Jianmei Qin, Peiyu Huang, Baorong Zhang, Wei Cheng, Jianfeng Feng, Xiaojun Xu, Linbo Wang, Minming Zhang
BACKGROUND: Whether there is hypothalamic degeneration in Parkinson's disease (PD) and its association with clinical symptoms and pathophysiological changes remains controversial. OBJECTIVES: We aimed to quantify microstructural changes in hypothalamus using a novel deep learning-based tool in patients with PD and those with probable rapid-eye-movement sleep behavior disorder (pRBD). We further assessed whether these microstructural changes associated with clinical symptoms and free thyroxine (FT4) levels...
March 11, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38477376/microglial-activation-and-progression-of-nigrostriatal-dysfunction-in-isolated-rem-sleep-behavior-disorder
#6
JOURNAL ARTICLE
Kristian Staer, Alex Iranzo, Morten Gersel Stokholm, Victor S Hvingelby, Erik Hvid Danielsen, Karen Østergaard, Mónica Serradell, Marit Otto, Kristina B Svendsen, Alicia Garrido, Dolores Vilas, Joan Santamaria, Arne Møller, Carles Gaig, David J Brooks, Per Borghammer, Eduardo Tolosa, Nicola Pavese
BACKGROUND: Using 11 C-(R)-PK11195-PET, we found increased microglia activation in isolated REM sleep behavior disorder (iRBD) patients. Their role remains to be clarified. OBJECTIVES: The objective is to assess relationships between activated microglia and progression of nigrostriatal dysfunction in iRBD. METHODS: Fifteen iRBD patients previously scanned with 11 C-(R)-PK11195 and 18 F-DOPA-PET underwent repeat 18 F-DOPA-PET after 3 years...
March 13, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/38470080/the-motor-dysfunction-seen-in-isolated-rem-sleep-behavior-disorder
#7
JOURNAL ARTICLE
Cristina Simonet, Laura Pérez-Carbonell, Miquel A Galmés-Ordinas, Brook F R Huxford, Harneek Chohan, Aneet Gill, Guy Leschziner, Andrew J Lees, Anette Schrag, Alastair J Noyce
BACKGROUND: Isolated Rapid Eye Movement (REM) sleep Behavior Disorder (iRBD) requires quantitative tools to detect incipient Parkinson's disease (PD). METHODS: A motor battery was designed and compared with the Movement Disorder Society-Unified Parkinson's Disease Rating Scale part III (MDS-UPDRS-III) in people with iRBD and controls. This included two keyboard-based tests (BRadykinesia Akinesia INcoordination tap test and Distal Finger Tapping) and two dual tasking tests (walking and finger tapping)...
March 12, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/38467937/comprehensive-proteomics-of-csf-plasma-and-urine-identify-ddc-and-other-biomarkers-of-early-parkinson-s-disease
#8
JOURNAL ARTICLE
Jarod Rutledge, Benoit Lehallier, Pardis Zarifkar, Patricia Moran Losada, Marian Shahid-Besanti, Dan Western, Priyanka Gorijala, Sephira Ryman, Maya Yutsis, Gayle K Deutsch, Elizabeth Mormino, Alexandra Trelle, Anthony D Wagner, Geoffrey A Kerchner, Lu Tian, Carlos Cruchaga, Victor W Henderson, Thomas J Montine, Per Borghammer, Tony Wyss-Coray, Kathleen L Poston
Parkinson's disease (PD) starts at the molecular and cellular level long before motor symptoms appear, yet there are no early-stage molecular biomarkers for diagnosis, prognosis prediction, or monitoring therapeutic response. This lack of biomarkers greatly impedes patient care and translational research-L-DOPA remains the standard of care more than 50 years after its introduction. Here, we performed a large-scale, multi-tissue, and multi-platform proteomics study to identify new biomarkers for early diagnosis and disease monitoring in PD...
March 11, 2024: Acta Neuropathologica
https://read.qxmd.com/read/38466158/presynaptic-dopaminergic-imaging-characterizes-patients-with-rem-sleep-behavior-disorder-due-to-synucleinopathy
#9
JOURNAL ARTICLE
Dario Arnaldi, Pietro Mattioli, Stefano Raffa, Matteo Pardini, Federico Massa, Alex Iranzo, Andres Perissinotti, Aida Niñerola-Baizán, Carles Gaig, Monica Serradell, Amaia Muñoz-Lopetegi, Gerard Mayà, Claudio Liguori, Mariana Fernandes, Fabio Placidi, Agostino Chiaravalloti, Karel Šonka, Petr Dušek, David Zogala, Jiri Trnka, Bradley F Boeve, Toji Miyagawa, Val J Lowe, Tomoyuki Miyamoto, Masayuki Miyamoto, Monica Puligheddu, Michela Figorilli, Alessandra Serra, Michele T Hu, Johannes C Klein, Frederik Bes, Dieter Kunz, Valérie Cochen De Cock, Delphine de Verbizier, Giuseppe Plazzi, Elena Antelmi, Michele Terzaghi, Irene Bossert, Kristína Kulcsárová, Alessio Martino, Alessandro Giuliani, Marco Pagani, Flavio Nobili, Silvia Morbelli
OBJECTIVE: To apply a machine learning analysis to clinical and presynaptic dopaminergic imaging data of patients with rapid eye movement (REM) sleep behavior disorder (RBD) to predict the development of Parkinson disease (PD) and dementia with Lewy bodies (DLB). METHODS: In this multicenter study of the International RBD study group, 173 patients (mean age 70.5 ± 6.3 years, 70.5% males) with polysomnography-confirmed RBD who eventually phenoconverted to overt alpha-synucleinopathy (RBD due to synucleinopathy) were enrolled, and underwent baseline presynaptic dopaminergic imaging and clinical assessment, including motor, cognitive, olfaction, and constipation evaluation...
March 11, 2024: Annals of Neurology
https://read.qxmd.com/read/38456361/cortical-macro-and-microstructural-changes-in-parkinson-s-disease-with-probable-rapid-eye-movement-sleep-behavior-disorder
#10
JOURNAL ARTICLE
Jèssica Pardo, Victor Montal, Anna Campabadal, Javier Oltra, Carme Uribe, Ignacio Roura, Núria Bargalló, Maria J Martí, Yaroslau Compta, Alex Iranzo, Juan Fortea, Carme Junqué, Bàrbara Segura
BACKGROUND: Evidence regarding cortical atrophy patterns in Parkinson's disease (PD) with probable rapid eye movement sleep behavior disorder (RBD) (PD-pRBD) remains scarce. Cortical mean diffusivity (cMD), as a novel imaging biomarker highly sensitive to detecting cortical microstructural changes in different neurodegenerative diseases, has not been investigated in PD-pRBD yet. OBJECTIVES: The aim was to investigate cMD as a sensitive measure to identify subtle cortical microstructural changes in PD-pRBD and its relationship with cortical thickness (CTh)...
March 8, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/38443213/melanopsin-retinal-ganglion-cell-function-in-alzheimer-s-vs-parkinson-s-disease-an-exploratory-meta-analysis-and-review-of-pupillometry-protocols
#11
REVIEW
Oliver Leopold Steiner, Jan de Zeeuw
BACKGROUND: Neurodegenerative diseases share retinal abnormalities. Chromatic pupillometry allows in vivo assessment of photoreceptor functional integrity, including melanopsin-expressing retinal ganglion cells. This exploratory meta-analysis assesses retinal photoreceptor functionality in Alzheimer's vs. Parkinson's disease and conducts an in-depth review of applied pupillometric protocols. METHODS: Literature reviews on PubMed and Scopus from 1991 to August 2023 identified chromatic pupillometry studies on Alzheimer's disease (AD; n = 42 patients from 2 studies) and Parkinson's disease (PD; n = 66 from 3 studies)...
February 27, 2024: Parkinsonism & related Disorders
https://read.qxmd.com/read/38437860/cholinergic-changes-in-lewy-body-disease-implications-for-presentation-progression-and-subtypes
#12
JOURNAL ARTICLE
Niels Okkels, Michel J Grothe, John-Paul Taylor, Steen Gregers Hasselbalch, Tatyana D Fedorova, Karoline Knudsen, Sygrid van der Zee, Teus van Laar, Nicolaas Bohnen, Per Borghammer, Jacob Horsager
Cholinergic degeneration is significant in Lewy body disease, including Parkinson's disease, dementia with Lewy bodies, and isolated REM sleep behavior disorder. Extensive research has demonstrated cholinergic alterations in the central nervous system of these disorders. More recently, studies have revealed cholinergic denervation in organs that receive parasympathetic denervation. This enables a comprehensive review of cholinergic changes in Lewy body disease, encompassing both central and peripheral regions, various disease stages, and diagnostic categories...
March 4, 2024: Brain
https://read.qxmd.com/read/38436278/neuronal-intranuclear-inclusion-disease-misdiagnosed-as-parkinson-s-disease-a-case-report
#13
JOURNAL ARTICLE
Dandan Yu, Jing Li, Hongfei Tai, Jing Ma, Zaiqiang Zhang, Wei Tang
Neuronal intranuclear inclusion disease (NIID) is a rare progressive neurodegenerative disease that mainly manifests as dementia, muscle weakness, sensory disturbances, and autonomic nervous dysfunction. Herein, we report a 68-year-old Chinese woman who was hospitalized because of resting tremor and bradykinesia that had been present for 7 years. Five years prior, bradykinesia and hypermyotonia had become apparent. She had urinary incontinence and rapid eye movement sleep behavior disorder. She was diagnosed with Parkinson's disease (PD) and received levodopa and pramipexole, which relieved her motor symptoms...
March 2024: Journal of International Medical Research
https://read.qxmd.com/read/38432692/predictors-for-early-onset-psychotic-symptoms-in-patients-newly-diagnosed-with-parkinson-s-disease-without-psychosis-at-baseline-a-5-year-cohort-study
#14
JOURNAL ARTICLE
Jing Chen, Baoyu Chen, Danhua Zhao, Xiaotong Feng, Qi Wang, Yuan Li, Junyi Chen, Chaobo Bai, Xintong Guo, Xiaoyu He, Lin Zhang, Junliang Yuan
AIMS: To investigate the risk factors for early-onset psychosis in Parkinson's disease (PD) in a cohort of patients from the Parkinson's Progression Markers Initiative. METHODS: Longitudinal data on motor and non-motor features, dopamine transporter (DAT) imaging, and cerebrospinal fluid (CSF) measurements were collected. The survival probability of psychotic symptoms, potential risk factors for psychosis development over a 5-year follow-up period, and the performance of the prediction model were evaluated...
March 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38430690/longitudinal-brain-changes-in-parkinson-s-disease-with-severe-olfactory-deficit
#15
JOURNAL ARTICLE
Kazuya Kawabata, Epifanio Bagarinao, Klaus Seppi, Werner Poewe
INTRODUCTION: Olfactory dysfunction and REM sleep behavior disorder (RBD) are associated with distinct cognitive trajectories in the course of Parkinson's disease (PD). The underlying neurobiology for this relationship remains unclear but may involve distinct patterns of neurodegeneration. This study aimed to examine longitudinal cortical atrophy and thinning in early-stage PD with severe olfactory deficit (anosmia) without and with concurrent probable RBD. METHODS: Longitudinal MRI data over four years of 134 de novo PD and 49 healthy controls (HC) from the Parkinson Progression Marker Initiative (PPMI) cohort were analyzed using a linear mixed-effects model...
February 27, 2024: Parkinsonism & related Disorders
https://read.qxmd.com/read/38427318/sleep-spindle-density-and-temporal-clustering-are-associated-with-sleep-dependent-memory-consolidation-in-parkinson-s-disease
#16
JOURNAL ARTICLE
Soraya Lahlou, Marta Kaminska, Julien Doyon, Julie Carrier, Madeleine Sharp
STUDY OBJECTIVES: Sleep is required for successful memory consolidation. Sleep spindles, bursts of oscillatory activity occurring during non-REM sleep, are known to be crucial for this process and, recently, it has been proposed that the temporal organization of spindles into clusters might additionally play a role in memory consolidation. In Parkinson's disease, spindle activity is reduced, and this reduction has been found to be predictive of cognitive decline. However, it remains unknown whether alterations in sleep spindles in Parkinson's disease are predictive of sleep-dependent cognitive processes like memory consolidation, leaving open questions about the possible mechanisms linking sleep and more general cognitive state in Parkinson's patients...
March 1, 2024: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://read.qxmd.com/read/38424131/sleep-disorders-in-parkinson-s-disease-an-early-and-multiple-problem
#17
JOURNAL ARTICLE
Pauline Dodet, Marion Houot, Smaranda Leu-Semenescu, Jean-Christophe Corvol, Stéphane Lehéricy, Graziella Mangone, Marie Vidailhet, Emmanuel Roze, Isabelle Arnulf
In Parkinson's disease (PD), it remains unclear whether sleep disorders including insomnia, REM sleep behavior disorder (RBD), excessive daytime sleepiness (EDS), restless legs syndrome (RLS) and sleep-disordered breathing (SDB), are isolated or combined, interact with each other and are associated with clinical factors. We sought to determine the prevalence and combinations of the main sleep disorders, and their clinical and polysomnographic associations in early stage PD. Sleep disorders were systematically diagnosed after medical interview and video-polysomnography in 162 participants with early stage PD and 58 healthy controls from the baseline of the longitudinal ICEBERG cohort...
February 29, 2024: NPJ Parkinson's Disease
https://read.qxmd.com/read/38409939/biomarkers-of-neurodegeneration-in-isolated-and-antidepressant-related-rapid-eye-movement-sleep-behavior-disorder
#18
JOURNAL ARTICLE
Francesco Biscarini, Fabio Pizza, Stefano Vandi, Alex Incensi, Elena Antelmi, Vincenzo Donadio, Raffaele Ferri, Rocco Liguori, Giuseppe Plazzi
BACKGROUND AND PURPOSE: This study compared the features of isolated rapid eye movement (REM) sleep behavior disorder (iRBD) and antidepressant-related REM sleep behaviour disorder (RBD) with the aim of highlighting markers that might distinguish the two entities. METHODS: The observational cohort study included RBD patients with and without antidepressant use (antiD+ and antiD- patients, respectively), without cognitive impairment and parkinsonism. Clinical features of RBD, subtle motor and non-motor symptoms of parkinsonism, sleep architecture, REM atonia index, dopamine transporter-single photon emission computed tomography (DAT-SPECT) and skin biopsies for the intraneuronal alpha-synuclein (α-syn), were evaluated in the baseline work-up...
February 26, 2024: European Journal of Neurology
https://read.qxmd.com/read/38390630/gba1-rs3115534-is-associated-with-rem-sleep-behavior-disorder-in-parkinson-s-disease-in-nigerians
#19
JOURNAL ARTICLE
Oluwadamilola Omolara Ojo, Sara Bandres-Ciga, Mary B Makarious, Peter Wild Crea, Dena G Hernandez, Henry Houlden, Mie Rizig, Andrew B Singleton, Alastair J Noyce, Mike A Nalls, Cornelis Blauwendraat, Njideka Ulunma Okubadejo
BACKGROUND: Rapid eye movement (REM) sleep behavior disorder (RBD) is an early feature of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Damaging coding variants in Glucocerebrosidase (GBA1) are a genetic risk factor for RBD. Recently, a population-specific non-coding risk variant (rs3115534) was found to be associated with PD risk and earlier onset in individuals of African ancestry. OBJECTIVES: We aimed to investigate whether the GBA1 rs3115534 PD risk variant is associated with RBD in persons with PD...
February 23, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/38375860/-hitting-and-yelling-during-sleep-diagnosis-and-implications-of-rem-sleep-behavior-disorder
#20
JOURNAL ARTICLE
Karin D van Dijk, Sirwan K L Darweesh, Odile A van den Heuvel, Sebastiaan Overeem, Ysbrand D van der Werf, W C T M Pijpers
Rapid eye movement (REM) sleep behavior disorder is characterized by dream enactment during REM sleep. Due to different treatment requirements, it is important to distinguish REM sleep behavior disorder from other causes of nocturnal restlessness, including sleep apnea, non-REM parasomnia and sleep-related hypermotor epilepsy. In addition, a diagnosis of isolated REM sleep behavior disorder is impactful, because it carries a greatly increased risk for the later development of Parkinson's disease and related synucleinopathies...
February 8, 2024: Nederlands Tijdschrift Voor Geneeskunde
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