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https://www.readbyqxmd.com/read/29157034/effects-of-single-dose-preemptive-pregabalin-and-intravenous-ibuprofen-on-postoperative-opioid-consumption-and-acute-pain-after-laparoscopic-cholecystectomy
#1
Omer Karaca, Huseyin U Pınar, Emin Turk, Rafi Dogan, Ali Ahiskalioglu, Sezen K Solak
PURPOSE: Non-opioid medications as a part of multimodal analgesia has been increasingly suggested in the management of acute post-surgical pain. The present study was planned to compare the efficacy of the combination of pregabalin plus ıv ibuprofen. METHODS: 58 patients were included in this prospective, randomized, double-blinded study. The pregabalin group (Group P, n = 29) received 150 mg pregabalin, the pregabalin plus ibuprofen group (Gropu PI, n = 29) received 150 mg pregabalin and 400mg ıv ibuprofen before surgery...
November 20, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29153295/effect-of-single-intra-cutaneous-injection-for-acute-thoracic-herpes-zoster-and-incidence-of-postherpetic-neuralgia
#2
Ji-Zheng Cui, Jin-Wei Zhang, Fang Yan, Xiao-Na Yang, Xin-Ling Wang, Zhi-Bin Zhao, Xiao-Bao Zhang, Zhu-Sheng Geng
The therapeutic effect of postherpetic neuralgia (PHN) is often disappointing and challenging. The role of intra-cutaneous injection of local anesthetic and steroids in preventing PHN remains unknown. The purpose of this study was to investigate the effect of a single intra-cutaneous injection of ropivacaine plus methylprednisolone on acute thoracic herpes zoster (HZ) pain intensity and duration, eruptive duration, and PHN incidence. A total of 97 patients with acute thoracic HZ diagnosed 1-7 days after the onset of the rash were randomly assigned to receive either 15 mL of 37...
November 15, 2017: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/29146440/clodronate-a-vesicular-atp-release-blocker
#3
REVIEW
Yoshinori Moriyama, Masatoshi Nomura
Clodronate is a first-generation bisphosphonate used worldwide for antiresorptive therapy for osteoporosis. Although clodronate is analgesic in nature, its mechanism and efficacy were unknown for some time. Recently, clodronate was identified as a selective and potent inhibitor for vesicular nucleotide transporter (VNUT), a transporter responsible for vesicular storage of ATP. Clodronate inhibits vesicular ATP release from neurons and reduces chronic neuropathic and inflammatory pain following blockade of purinergic chemical transmission...
November 13, 2017: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/29121288/benefit-and-harm-of-pregabalin-in-acute-pain-treatment-a-systematic-review-with-meta-analyses-and-trial-sequential-analyses
#4
M L Fabritius, C Strøm, S Koyuncu, P Jæger, P L Petersen, A Geisler, J Wetterslev, J B Dahl, O Mathiesen
Pregabalin has demonstrated anti-hyperalgesic properties and was introduced into acute pain treatment in 2001. Our aim was to evaluate the beneficial and harmful effects of pregabalin in postoperative pain management. We included randomized clinical trials investigating perioperative pregabalin treatment in adult surgical patients. The review followed Cochrane methodology, including Grading of Recommendations Assessment, Development, and Evaluation (GRADE), and used trial sequential analyses (TSAs). The primary outcomes were 24 h morphine i...
October 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29111014/negative-myoclonus-induced-by-gabapentin-and-pregabalin-a-case-series-and-systematic-literature-review
#5
Jung Bin Kim, Jin-Man Jung, Moon-Ho Park, Eun Ju Lee, Do-Young Kwon
INTRODUCTION: Negative myoclonus is a jerky, brief, and sudden interruption of voluntary muscle contraction. Although gabapentin and pregabalin have been reported to induce positive myoclonus in some patients with impaired renal function, there are only a few studies describing pregabalin- or gabapentin-induced negative myoclonus. This study reviewed patients who had developed pregabalin- or gabapentin-induced negative myoclonus. METHODS: We collected the patients with negative myoclonus who were referred to the department of neurology at a university-affiliated hospital and selected pregabalin- or gabapentin-induced negative myoclonus...
November 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29104044/calcitonin-potentiates-the-anticonvulsant-and-antinociceptive-effects-of-valproic-acid-and-pregabalin-in-pentylenetetrazole-kindled-mice
#6
Nada M Hamada, Rehab H Ashour, Amany A Shalaby, Hussien M El-Beltagi
Antiepileptic drugs are the backbone for epilepsy management. Epilepsy may be accompanied by decreased pain threshold. Thus, anticonvulsant agents with antinociceptive properties are of great importance. This study investigated the possible anticonvulsant and antinociceptive effects of calcitonin in combination with either valproic acid or pregabalin and whether these effects might occur through γ-aminobutyric acid (GABA) modulation. Eighty-four male Balb/C mice were divided into 7 groups: control-naïve, pentylenetetrazole (PTZ)-induced seizures, PTZ-calcitonin, PTZ-valproic acid, PTZ-pregabalin, PTZ-calcitonin-valproic acid (PCV) combination, and PTZ-calcitonin-pregabalin (PCP) combination...
November 2, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29102165/effect-of-pregabalin-and-diclofenac-on-tactile-allodynia-mechanical-hyperalgesia-and-pro-inflammatory-cytokine-levels-il-6-il-1%C3%AE-induced-by-chronic-constriction-injury-of-the-infraorbital-nerve-in-rats
#7
Junad Khan, Noma Noboru, Yoshiki Imamura, Eli Eliav
The present study evaluated the effects of systemic pregabalin (PG) and diclofenac (Dic) on neuropathic orofacial pain induced by chronic constriction injury (CCI) of the infraorbital nerve (ION) and on the pro-inflammatory cytokines levels in the affected nerve. Fifty-four rats underwent left infra orbital nerve CCI, and 7 days after the procedure as the pain developed, the rats were randomly assigned to one of the treatment groups: PG 300, 30 or 10 mg/kg, Dic 10, 5 or 1 mg/kg or saline group (Sal) (n/group = 8)...
October 25, 2017: Cytokine
https://www.readbyqxmd.com/read/29101547/oral-pregabalin-for-acute-pain-relief-after-cervicofacial-surgery-a-systematic-review
#8
REVIEW
Sara Liébana-Hermoso, Francisco Javier Manzano-Moreno, Manuel Francisco Vallecillo-Capilla, Maria Victoria Olmedo-Gaya
OBJECTIVE: The objectives of this systematic review were to unify criteria on the effectiveness of oral pregabalin to treat acute post-operative pain after cervicofacial surgery, to establish the most effective dose regimens, and to determine its effect on rescue medicine consumption and its association with adverse effects. MATERIALS AND METHODS: PubMed/Medline (National Library of Medicine, Washington, DC), Scopus, Web of Science, and Cochrane databases were searched for studies in any language published between January 2000 and September 2016...
November 3, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29080243/limaprost-or-pregabalin-preoperative-and-postoperative-medication-for-pain-due-to-lumbar-spinal-stenosis
#9
Yuji Kasukawa, Naohisa Miyakoshi, Takashi Kobayashi, Kazuma Kikuchi, Kunio Ebata, Noriyuki Ishikawa, Tetsuya Suzuki, Hiroshi Sasaki, Yuji Hatakeyama, Michio Hongo, Yoshinori Ishikawa, Daisuke Kudo, Toshiki Abe, Koichiro Okuyama, Tadato Kido, Mitsuho Chiba, Toyohito Segawa, Masazumi Suzuki, Takashi Mizutani, Ryota Kimura, Yuichi Ono, Jumpei Iida, Eiji Abe, Yoichi Shimada
PURPOSE: We aimed to evaluate the incidence of (and risk factors for) postoperative pregabalin and/or limaprost to treat persistent numbness and/or pain of the lower extremities after lumbar spinal stenosis (LSS) surgery. METHODS: Medical records of 329 patients (168 men 161 women; average age 70 years) were retrospectively reviewed for data on the duration of LSS diagnosis; LSS disease; preoperative medication (limaprost, pregabalin, combined limaprost/pregabalin; duration); symptoms; preoperative/postoperative intermittent claudication (IC); operation type; postoperative medication and period)...
October 27, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29066930/the-effect-of-pregabalin-or-duloxetine-on-arthritis-pain-a-clinical-and-mechanistic-study-in-people-with-hand-osteoarthritis
#10
Nidhi Sofat, Abiola Harrison, Mark D Russell, Salma Ayis, Patrick D Kiely, Emma H Baker, Thomas Richard Barrick, Franklyn A Howe
Osteoarthritis (OA) is the most prevalent arthritis worldwide and is characterized by chronic pain and impaired physical function. We hypothesized that heightened pain in hand OA could be reduced with duloxetine or pregabalin. In this prospective, randomized clinical study, we recruited 65 participants, aged 40-75 years, with a Numerical Rating Scale (NRS) for pain of at least 5. Participants were randomized to one of the following three groups: duloxetine, pregabalin, and placebo. The primary endpoint was the NRS pain score, and the secondary endpoints included the Australian and Canadian Hand Osteoarthritis Index (AUSCAN) pain, stiffness, and function scores and quantitative sensory testing by pain pressure algometry...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29064627/interpreting-the-effectiveness-of-opioids-and-pregabalin-for-pain-severity-pain-interference-and-fatigue-in-fibromyalgia-patients
#11
Fred Davis, Mark Gostine, Bradley A Roberts, Rebecca Risko, Joseph C Cappelleri, Alesia Sadosky
OBJECTIVE: To evaluate the effectiveness of opioids and/or pregabalin on patient-reported outcomes among fibromyalgia (FM) patients based on levels of improvement. METHODS: A total of 1,421 FM patients were identified with 3,082 observational periods of opioids with or without pregabalin use between April 2008 and February 2015. Patients were categorized by opioids, and pregabalin with and without opioids; opioids were designated by morphine equivalent dose (MED) of ≤20 (low MED), >20 to <100 (moderate MED), ≥100 (high MED), and pregabalin dosages ≤150mg, 151- 300mg, and 301-450mg...
October 24, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29049110/evidence-for-the-efficacy-of-systemic-opioid-sparing-analgesics-in-pediatric-surgical-populations-a-systematic-review
#12
REVIEW
Alyssa Zhu, Hubert A Benzon, T Anthony Anderson
While a large number of studies has examined the efficacy of opioid-sparing analgesics in adult surgical populations, fewer studies are available to guide postoperative pain treatment in pediatric patients. We systematically reviewed available publications on the use of systemic nonopioid agents for postoperative analgesia in pediatric surgical populations. A comprehensive literature search identified meta-analyses and randomized controlled trials (RCTs) assessing the effects of systemic, nonopioid agents on postoperative narcotic requirements or pain scores in pediatric surgical populations...
November 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29039325/comparative-role-of-pregabalin-and-carbamazepine-regarding-efficacy-in-painful-diabetic-neuropathy
#13
Raana Mahmood, Itrat Jawed, M Irfan Khan, Iffat Mahmood, Talat Tariq, Arfa Kamil, Faiza Z Sayeed, Bushra Z Sayeed
Neuropathic pain is the most severe and resistant type of pain which has impact on quality of life and behaviour; it most commonly occurs at night causing disturbed sleep. Diabetes mellitus is a common cause of painful neuropathy. In this study, we are comparing the effectiveness of old treatment Carbamazepine with Pregabalin in painful diabetic neuropathy. The study was an open-label trial conducted in Diabetic Clinic of Medical Unit-III, Jinnah Post-graduate Medical Center, Karachi. The duration of the study was 90 days, from December 2010 to March 2011...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29026967/a-rat-model-of-folfox-induced-neuropathy-effects-of-oral-dimiracetam-in-comparison-with-duloxetine-and-pregabalin
#14
Lorenzo Di Cesare Mannelli, Mario Maresca, Laura Micheli, Carlo Farina, Michael W Scherz, Carla Ghelardini
BACKGROUND AND AIM: The FOLFOX family of chemotherapy regimens are hampered by the development of a painful neuropathy. Current clinical treatments are inadequate, and furthermore, the research of innovative drugs is strongly disadvantaged by the absence of a preclinical model based on the complete mixture of FOLFOX components. The aim of this study was to set up a rat model of FOLFOX-induced neuropathy in rats, validate its predictability by reference drugs, and evaluate the effectiveness of the new anti-neuropathic compound dimiracetam...
October 12, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29023146/is-there-a-role-for-combined-use-of-gabapentin-and-pregabalin-in-pain-control-too-good-to-be-true
#15
Helen Senderovich, Geetha Jeyapragasan
Gabapentin (Neurontin) and Pregabalin (Lyrica) are first and second-generation α2δ [1,2] ligands, respectively, and are both approved for use as adjunctive therapy in pain control. Although they do not bind to gamma-aminobutyric acid (GABA) receptors they have been successfully used to treat neuropathic pain conditions. Their mechanism of action is not yet fully understood, but research has demonstrated promising results. Despite their similarities, they have been used in combination in both clinical and research situations, and have been noted to have a synergistic effect in pain control without concern for clinically significant pharmacokinetic interactions...
October 12, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29016927/clinical-use-of-pregabalin-in-general-practice-in-catalonia-spain-a-population-based-cross-sectional-study
#16
Montserrat Viñas-Bastart, Míriam Oms-Arias, Àfrica Pedraza-Gutiérrez, Irene Lizano-Díez, Pilar Modamio, Eduardo L Mariño
Objective: The aim of this study was to determine the pattern of use of pregabalin and the appropriateness of treatment, so that interventions could be designed to improve various clinical approaches to the use of pregabalin to include unlicensed indications. Design: A descriptive, cross-sectional, multicenter study was performed between April 2014 and January 2015. Setting: Fifty-three primary health care centers covering 1,250,000 inhabitants...
July 17, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28991361/withdrawn-anticonvulsants-for-fibromyalgia
#17
REVIEW
Nurcan Üçeyler, Claudia Sommer, Brian Walitt, Winfried Häuser
BACKGROUND: Fibromyalgia (FM) is a clinically well-defined chronic condition of unknown aetiology characterised by chronic widespread pain that often co-exists with sleep problems and fatigue. People often report high disability levels and poor health-related quality of life (HRQoL). Drug therapy focuses on reducing key symptoms and disability, and improving HRQoL. Anticonvulsants (antiepileptic drugs) are drugs frequently used for the treatment of chronic pain syndromes. OBJECTIVES: To assess the benefits and harms of anticonvulsants for treating FM symptoms...
October 9, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28988433/does-a-single-dose-of-pregabalin-help-with-postoperative-pain-after-septoplasty
#18
Ni Chen, Christian Soneru, Ashutosh Kacker
No abstract text is available yet for this article.
October 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28984402/efficacy-acceptability-and-safety-of-cognitive-behavioural-therapies-in-fibromyalgia-syndrome-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#19
REVIEW
K Bernardy, P Klose, P Welsch, W Häuser
This updated systematic review aimed at evaluating the efficacy, acceptability and safety of cognitive behavioural therapies (CBTs) in fibromyalgia syndrome (FMS). Clinicaltrials.gov, Cochrane Library, MEDLINE, PsycINFO and SCOPUS were searched from September 2013 to May 2017. Randomized controlled trials (RCTs) comparing CBTs with controls were analysed. Primary outcomes were ≥50% pain relief, ≥20% improvement of health-related quality of life (HRQoL), negative mood, fatigue, disability, acceptability and safety at end of therapy and at 6 months follow-up...
October 6, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28972983/gabapentin-opioids-and-the-risk-of-opioid-related-death-a-population-based-nested-case-control-study
#20
Tara Gomes, David N Juurlink, Tony Antoniou, Muhammad M Mamdani, J Michael Paterson, Wim van den Brink
BACKGROUND: Prescription opioid use is highly associated with risk of opioid-related death, with 1 of every 550 chronic opioid users dying within approximately 2.5 years of their first opioid prescription. Although gabapentin is widely perceived as safe, drug-induced respiratory depression has been described when gabapentin is used alone or in combination with other medications. Because gabapentin and opioids are both commonly prescribed for pain, the likelihood of co-prescription is high...
October 2017: PLoS Medicine
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