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https://www.readbyqxmd.com/read/27914698/under-prescription-of-statins-in-patients-with-non-alcoholic-fatty-liver-disease
#1
M Del Ben, F Baratta, L Polimeni, D Pastori, L Loffredo, M Averna, F Violi, F Angelico
BACKGROUND AND AIM: Non-alcoholic fatty liver disease (NAFLD) is a common disease associated with high cardiovascular risk. Management of dyslipidaemia plays a pivotal role in the prevention of CV events and statins have proved to be safe in these patients. However, in everyday clinical practice statin prescription is sometimes limited because of the concern of physicians about side-effects. The aim of the study was to investigate if the presence of NAFLD affects the prescription of lipid-lowering treatment in a large series of patients with cardio-metabolic disorders...
September 28, 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/27912784/liraglutide-improves-metabolic-parameters-and-carotid-intima-media-thickness-in-diabetic-patients-with-the-metabolic-syndrome-an-18-month-prospective-study
#2
Manfredi Rizzo, Ali A Rizvi, Angelo Maria Patti, Dragana Nikolic, Rosaria Vincenza Giglio, Giuseppa Castellino, Giovanni Li Volti, Massimiliano Caprio, Giuseppe Montalto, Vincenzo Provenzano, Stefano Genovese, Antonio Ceriello
BACKGROUND: Liraglutide, a GLP-1 analogue, exerts several beneficial non-glycemic effects in patients with type-2 diabetes (T2DM), such as those on body weight, blood pressure, plasma lipids and inflammation markers. However, the effects of liraglutide on cardiovascular (CV) risk markers in subjects with the metabolic syndrome (MetS) are still largely unknown. We herein explored its effects on various cardio-metabolic risk markers of the MetS in subjects with T2DM. METHODS: We performed an 18-month prospective, real-world study...
December 3, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27880884/anti-atherosclerosis-and-cardio-protective-effects-of-the-angong-niuhuang-pill-on-a-high-fat-and-vitamin-d3-induced-rodent-model-of-atherosclerosis
#3
Wen-Juan Fu, Ting Lei, Zhen Yin, Jian-Hao Pan, Yu-Shuang Chai, Xiao-Yun Xu, Yi-Xi Yan, Zhi-Hua Wang, Jian Ke, Gang Wu, Ren-He Xu, Manish Paranjpe, Lintao Qu, Hong Nie
ETHNOPHARMACOLOGICAL RELEVANCE: The Angong Niuhuang Pill (ANP) is a well known Chinese traditional therapeutic for the treatment for diseases affecting the Central Nervous System (CNS). Components of the ANP formulation, including Bovis Calculus Sativus, Pulvis Bubali Comus Concentratus, Moschus, Margarita, Cinnabaris, Realgar, Coptidis Rhizoma, Scutellariae Radix, Gardeniae Fructus, Curcumae Radix, and Bomeolum Syntheticum, have been used for the treatment of stroke, encephalitis and emergency meningitis across Asia, especially in China for hundreds of years...
November 20, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27863915/prenatal-ultrasound-monitoring-of-homozygous-%C3%AE-0-thalassemia-induced-fetal-anemia
#4
REVIEW
Helena H L Lee, Annisa S L Mak, C F Poon, K Y Leung
A noninvasive approach by serial ultrasound examination at 12-15, 18, and 30 weeks of gestation can be used to exclude homozygous α(0)-thalassemia-induced fetal anemia. At 12-15 weeks of gestation, the predictive values for the fetal cardio-thoracic ratio were better than that for the placental thickness. At 16-20 weeks of gestation, measuring middle cerebral artery peak systolic velocity is associated with a low false-positive rate. However, the false-positive rate of this noninvasive approach can be about 3%, requiring an invasive test to confirm the diagnosis...
October 26, 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27819640/mature-teratoma-associated-with-bilateral-ovarian-carcinosarcoma-accidental-association-or-etiopathogenetic-determinism-case-report
#5
Rodica Birla, Elena-Roxana Catanescu, Andrei Caragui, Silviu Constantinoiu
Carcinosarcoma is a rare form of ovarian cancer with mixed origin, and its association with mature teratoma is extremely rare. We present the case of patient T. M. aged 67, admitted into our clinic on the 15/05/2016, F.O. 4877 for the increase of the abdominal volume. On admission, the patient was afebrile, conscious, cooperative, cardio-respiratory balanced, having the abdomen distended in volume, sharp dullness in the flanks, positive wave sign bioumoral within normal limits except: uric acid = 6.64 mg / dL, serum glucose = 113...
2016: Chirurgia
https://www.readbyqxmd.com/read/27665506/cardio-renal-syndrome-type-4-the-correlation-between-cardiorenal-ultrasound-parameters
#6
Silvia Lai, Mauro Ciccariello, Mira Dimko, Alessandro Galani, Silvio Lucci, Rosario Cianci, Amalia Mariotti
: Bakground/Aims: Cardiovascular diseases represent the leading causes of morbidity and mortality in patients with cronich kidney disease (CKD). The pathogenesis includes a complex, bidirectional interaction between heart and kidney termed cardiorenal syndrome type 4. The aim of study was to evaluate the association between renal and cardiovascular ultrasonographic parameters and identify early markers of cardiovascular risk. METHODS: A total of 35 patients with CKD and 25 healthy controls, were enrolled and we have evaluated inflammatory indexes, mineral metabolism, renal function, renal and cardiovascular ultrasonographic parameters...
2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27642290/machine-learning-to-predict-rapid-progression-of-carotid-atherosclerosis-in-patients-with-impaired-glucose-tolerance
#7
Xia Hu, Peter D Reaven, Aramesh Saremi, Ninghao Liu, Mohammad Ali Abbasi, Huan Liu, Raymond Q Migrino
OBJECTIVES: Prediabetes is a major epidemic and is associated with adverse cardio-cerebrovascular outcomes. Early identification of patients who will develop rapid progression of atherosclerosis could be beneficial for improved risk stratification. In this paper, we investigate important factors impacting the prediction, using several machine learning methods, of rapid progression of carotid intima-media thickness in impaired glucose tolerance (IGT) participants. METHODS: In the Actos Now for Prevention of Diabetes (ACT NOW) study, 382 participants with IGT underwent carotid intima-media thickness (CIMT) ultrasound evaluation at baseline and at 15-18 months, and were divided into rapid progressors (RP, n = 39, 58 ± 17...
December 2016: EURASIP Journal on Bioinformatics & Systems Biology
https://www.readbyqxmd.com/read/27514305/vein-of-galen-aneurysmal-malformation-vgam-in-the-fetus-a-retrospective-analysis-of-perinatal-prognostic-indicators-in-a-two-center-series-of-49-cases
#8
D Paladini, B Deloison, A Rossi, G E Chalouhi, C Gandolfo, P Sonigo, S Buratti, A E Millischer, G Tuo, Y Ville, A Pistorio, A Cama, L J Salomon
OBJECTIVE: Vein of Galen aneurysmal malformation (VGAM) is a rare anomaly in which an adequate perinatal management may warrant good neurological outcome. However, most fetal series are too scant to allow reliable statistical assessment of poor prognostic factors. Aim of this paper is to assess, in a two-center series of 49 cases, the prognostic value of several prenatal variables. The primary endpoint of the analysis is to identify possible prenatal indicators of poor outcome, in terms of mortality and cerebral disabilities...
August 12, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27433943/serum-levels-of-lp-a-are-related-to-waist-circumference-in-nafld-patients-with-low-prevalence-of-co-morbidities
#9
Giovanni Tarantino, Carmine Finelli, Saverio Gioa, Vincenzo Citro, Nicolina La Sala, Marco Gentile
BACKGROUND: Novel evidence suggests a relationship between circulating Lp(a) levels and the presence of cardiovascular events independently from the cardio-metabolic profile. METHODS AND RESULTS: The purpose of this study was to investigate serum Lp(a) concentrations in relation to carotid intima-media thickness (IMT), anthropometric measures, lipid profile, assessment of insulin resistance, and other parameters conventionally used to predict CVD risk, in obese patients suffering from hepatic steatosis (HS), the well-known nonalcoholic fatty liver disease (NAFLD)...
November 2016: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/27322245/next-generation-sequencing-approach-in-a-prenatal-case-of-cardio-facio-cutaneus-syndrome
#10
Mafalda Mucciolo, Claudio Dello Russo, Laura D'Emidio, Alvaro Mesoraca, Claudio Giorlandino
Cardiofaciocutaneous syndrome (CFCS) belongs to a group of developmental disorders due to defects in the Ras/Mitogen-Activated Protein Kinase (RAS/MAPK) signaling pathway named RASophaties. While postnatal presentation of these disorders is well known, the prenatal and neonatal characteristics are less recognized. Noonan syndrome, Costello syndrome, and CFCS diagnosis should be considered in pregnancies with a normal karyotype and in the case of ultrasound findings such as increased nuchal translucency, polyhydramnios, macrosomia and cardiac defect...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27167596/ultrasound-assessment-of-endothelial-function-a-technical-guideline-of-the-flow-mediated-dilation-test
#11
Paula Rodriguez-Miguelez, Nichole Seigler, Ryan A Harris
Cardiovascular disease is the primary cause of mortality and a major cause of disability worldwide. The dysfunction of the vascular endothelium is a pathological condition characterized mainly by a disruption in the balance between vasodilator and vasoconstrictor substances and is proposed to play an important role in the development of atherosclerotic cardiovascular disease. Therefore, a precise evaluation of endothelial function in humans represents an important tool that could help better understand the etiology of multiple cardio-centric pathologies...
2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27143395/interrelationships-among-various-measures-of-central-artery-stiffness
#12
Jisok Lim, Miriam Pearman, Wonil Park, Mohammed Alkatan, Hirofumi Tanaka
BACKGROUND: A number of different techniques and methodologies have been applied to quantify stiffness of arteries. Because measures of arterial stiffness differ in regards to measurement locations as well as properties, it is not clear how well these measures that are supposed to reflect the same arterial wall properties are related. METHODS: Interrelationships between different measures of arterial stiffness were evaluated in 50 apparently healthy subjects varying in age...
September 2016: American Journal of Hypertension
https://www.readbyqxmd.com/read/27125366/non-classical-monocytes-predict-progression-of-carotid-artery-bifurcation-intima-media-thickness-in-hiv-infected-individuals-on-stable-antiretroviral-therapy
#13
Dominic C Chow, Jamie M Kagihara, Guangxiang Zhang, Scott A Souza, Howard N Hodis, Yanjie Li, Brooks I Mitchell, Beau K Nakamoto, Kalpana J Kallianpur, Sheila M Keating, Philip J Norris, Lindsay B Kohorn, Lishomwa C Ndhlovu, Cecilia M Shikuma
BACKGROUND: Inflammation may contribute to cardiovascular disease (CVD) among antiretrovirally suppressed HIV-infected individuals. We assessed relationships of monocyte, CD8 T-cell activation and plasma biomarkers to changes in carotid artery intima-media thickness (CIMT). METHODS: Longitudinal study of HIV-infected subjects ≥40 years and on stable antiretroviral therapy (ART) ≥3 months. Peripheral blood mononuclear cells were immunophenotyped by multiparameteric flow cytometry to quantify classical (CD14(++)CD16(-)), intermediate (CD14(++)CD16(+)), non-classical (CD14(low/+)CD16(++)) and transitional (CD14(+)CD16(-)) monocyte subsets and activated (CD38(+)HLA-DR(+)) CD8(+) T-cells at baseline...
May 2016: HIV Clinical Trials
https://www.readbyqxmd.com/read/26944724/the-coexistence-of-carotid-and-lower-extremity-atherosclerosis-further-increases-cardio-cerebrovascular-risk-in-type-2-diabetes
#14
Mei-Fang Li, Cui-Chun Zhao, Ting-Ting Li, Yin-Fang Tu, Jun-Xi Lu, Rong Zhang, Ming-Yun Chen, Yu-Qian Bao, Lian-Xi Li, Wei-Ping Jia
BACKGROUND: Both carotid and lower limb atherosclerosis are associated with increased cardiovascular and cerebrovascular risks. However, it is still unclear whether the concomitant presence of carotid and lower extremity atherosclerosis further increases the cardiovascular and cerebrovascular risks. Therefore, our aim is to investigate whether the coexistence of carotid and lower extremity atherosclerosis was associated with higher cardiovascular and cerebrovascular risks in patients with type 2 diabetes...
2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/26847108/a-prospective-single-centre-randomised-study-evaluating-the-clinical-imaging-and-immunological-depth-of-remission-achieved-by-very-early-versus-delayed-etanercept-in-patients-with-rheumatoid-arthritis-vedera
#15
RANDOMIZED CONTROLLED TRIAL
Raluca B Dumitru, Sarah Horton, Richard Hodgson, Richard J Wakefield, Elizabeth M A Hensor, Paul Emery, Maya H Buch
BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory arthritis, with significant impact on quality of life and functional status. Whilst biologic disease modifying anti-rheumatic drugs (bDMARD) such as tumour necrosis factor-inhibitor (TNFi) agents have revolutionised outcomes in RA, early diagnosis with immediate conventional therapy, titrated in a treat to target approach is also associated with high remission rates. The main aim of the VEDERA study (Very Early versus Delayed Etanercept in Rheumatoid Arthritis) is to assess the depth of remission, sustainability of remission and immunological normalisation induced by very early TNFi with etanercept (ETN) or standard of care +/- delayed ETN...
February 5, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/26649350/ultrasound-in-the-evaluation-of-penetrating-thoraco-abdominal-trauma-a-review-of-the-literature
#16
REVIEW
Nicholas J Governatori, Turandot Saul, Sebastian D Siadecki, Resa E Lewiss
The use of ultrasound in the evaluation of blunt thoraco-abdominal trauma is well described. Evidence for the use of ultrasound in the evaluation of penetrating cardio-thoracic and abdominal trauma, however, is more limited and varied. Current literature demonstrates that ultrasound is an excellent screening tool for penetrating thoracic and cardiac injuries with a high sensitivity for detecting injury requiring acute intervention. For abdominal injuries, however, the sensitivity for detection of injury is low and thus the utility of ultrasound as a screening tool is limited...
December 2015: Medical Ultrasonography
https://www.readbyqxmd.com/read/26632075/vascular-and-chronological-age-in-subjects-with-erectile-dysfunction-a-cross-sectional-study
#17
Giulia Rastrelli, Giovanni Corona, Edoardo Mannucci, Mario Maggi
INTRODUCTION: Vascular age, as derived from the SCORE project algorithm for cardiovascular (CV) risk estimation, is an effective way for communicating CV risk. However, studies on its clinical correlates are scanty. AIM: To evaluate if the difference between vascular and chronological age (Δage), in a population of subjects with erectile dysfunction (ED), can identify men with a worse risk profile. METHODS: A consecutive series of 2,853 male patients attending the outpatient clinic for erectile dysfunction (ED) for the first time was retrospectively studied...
December 2015: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/26494162/prenatal-findings-in-cardio-facio-cutaneous-syndrome
#18
Ludivine Templin, Clarisse Baumann, Tiffany Busa, Hélène Heckenroth, Nathalie Pouvreau, Annick Toutain, Hélène Cave, Alain Verloes, Sabine Sigaudy, Nicole Philip
Our study was designed to analyze prenatal manifestations in patients affected with cardio-facio-cutaneous syndrome (CFCS), in order to define indications of DNA testing in utero. Prenatal features were extracted from a national database and additional data were collected from 16 families contacted through the French association of CFC-Costello syndrome. We collected results of ultrasound scan (USS) biometrics, presence of congenital birth defects, and polyhydramnios. From the database, increased nuchal translucency was present in 13% of pregnancies, polyhydramnios in 52%, macrosomia and/or macrocephaly in 16%...
February 2016: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/26306788/elusive-angiostrongylus-vasorum-infections
#19
Angela Di Cesare, Donato Traversa, Simone Manzocchi, Silvana Meloni, Eleonora Grillotti, Edoardo Auriemma, Fabrizio Pampurini, Cecilia Garofani, Fabrizio Ibba, Luigi Venco
BACKGROUND: The parasitic nematode Angiostrongylus vasorum causes severe clinical signs in dogs. The disease is often challenging because infected animals are often presented with clinical signs overlapping those of other diseases. METHODS: The present article describes six angiostrongylosis cases (Cases 1-6) that represent key examples of how canine angiostrongylosis may be extremely confounding. The six animals presented clinical signs compatible with canine angiostrongylosis but they were subjected to clinical examinations for other diseases (e...
2015: Parasites & Vectors
https://www.readbyqxmd.com/read/26196008/cayler-cardio-facial-syndrome-an-uncommon-condition-in-newborns
#20
Sunil Jayaram Pawar, Deepak Kumar Sharma, Sela Srilakshmi, Suguna Reddy Chejeti, Aakash Pandita
INTRODUCTION: Cayler cardio-facial syndrome is a rare syndrome associated with asymmetric crying faces with congenital heart disease. We report a newborn that was diagnosed as case of Cayler Cardio-facial syndrome based on clinical features and was confirmed with FISH analysis. CASE PRESENTATION: A term male baby, born to non-consanguineous couple through normal vaginal delivery was diagnosed to have asymmetric crying faces with deviation of angle of mouth to left side at the time of birth...
April 2015: Iranian Journal of Pediatrics
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