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Liver metastasis imaging

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https://www.readbyqxmd.com/read/28543544/the-prognostic-utility-of-the-tumor-burden-score-based-on-preoperative-radiographic-features-of-colorectal-liver-metastases
#1
Kazunari Sasaki, Georgios A Margonis, Nikolaos Andreatos, Xu-Feng Zhang, Stefan Buettner, Jaeyun Wang, Amar Deshwar, Jin He, Christopher L Wolfgang, Matthew Weiss, Timothy M Pawlik
BACKGROUND: Recently, a tumor-burden "metro ticket" score (TBS) based on final pathology was proposed to predict outcome following resection of colorectal liver metastasis (CRLM). We sought to validate the TBS prognostic tool using preoperative radiologic cross-sectional imaging. METHODS: Imaging TBS was defined on a Cartesian plane that incorporated both maximum tumor size (x-axis) and lesion number (y-axis) assessed by pre-operative imaging. The discriminatory power (area under the curve [AUC]) and goodness-of-fit (Harrel's C statistic and Somer's D statistics) of the imaging TBS model was assessed...
May 25, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28540062/frequency-and-locations-of-systemic-metastases-in-merkel-cell-carcinoma-by-imaging
#2
Maria Kouzmina, Virve Koljonen, Junnu Leikola, Tom Böhling, Eila Lantto
BACKGROUND: The primary neuroendocrine skin cancer, Merkel cell carcinoma (MCC), has a well-known predilection to metastasize systemically. However, the experience of systemic metastases in MCC is mainly disseminated through case reports due to the rarity of MCC. PURPOSE: To elucidate the frequency and locations of systemic metastasis in MCC by reviewing the imaging of patients with metastatic MCC in a national cohort. MATERIAL AND METHODS: Patients with diagnosed metastatic MCC by imaging studies in Finland during 1999-2012 were included in this study...
March 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/28533646/image-findings-of-rare-case-of-peritoneal-carcinomatosis-from-non-small-cell-lung-cancer-and-response-to-erlotinib-in-f-18-fdg-positron-emission-tomography-computed-tomography
#3
Koramadai Karuppusamy Kamaleshwaran, Jephy Joseph, Radha Krishnan Kalarikal, Ajit Sugunan Shinto
Lung cancer is currently one of the most common malignancies in the world. Metastatic disease is observed in ~ 40% of patients with lung cancer, with the most common sites of metastasis being the bone, liver, brain and adrenal glands. Peritoneal carcinomatosis (PC) is defined as the progression of the primary cancer to the peritoneum. PC is a rare clinical event in lung cancer. Tyrosine kinase inhibitors targeting the epidermal growth factor receptor (EGFR), such as erlotinib are used for the treatment of patients with advanced non-small cell lung cancer (NSCLC)...
April 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28533641/image-findings-of-a-rare-case-of-neuroendocrine-tumor-metastatic-to-orbital-extraocular-muscle-in-gallium-68-dotanoc-positron-emission-tomography-computed-tomography-and-therapy-with-lutetium-177-dotatate
#4
Koramadai Karuppusamy Kamaleshwaran, Jephy Joseph, Indra Upadhya, Ajit Sugunan Shinto
Metastatic tumor is one of several etiologies of space-occupying masses in the orbit that accounts for 1-13% of all orbital masses. In the adult patient population, breast cancer is the most common tumor to metastasize to the orbit, followed by metastasis from the lung, prostate, and gastrointestinal tract. Carcinoid tumors are rare neuroendocrine neoplasms derived from enterochromaffin cells, which are found primarily in the gastrointestinal tract and bronchial tree. Liver metastases are the classic presentation of distant disease...
April 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28521452/assessment-of-high-sensitivity-c-reactive-protein-tests-for-the-diagnosis-of-hepatocellular-carcinoma-in-patients-with-hepatitis-b-associated-liver-cirrhosis
#5
Li-Na Ma, Xiao-Yan Liu, Zhen-Hui Lu, Li-Gang Wu, Yuan-Yuan Tang, Xia Luo, Yan-Chao Hu, Ting-Ting Yan, Qi Wang, Xiang-Chun Ding, Yan Xie
Hepatocellular carcinoma (HCC) is a common malignant tumor worldwide, with high morbidity and mortality. Chronic infection with hepatitis B virus (HBV) is a major risk factor for the development of hepatocellular carcinoma and the majority (~80%) of hepatocellular carcinoma patients in China exhibit co-morbidity with HBV-associated liver cirrhosis. The goal of reliable early diagnostic and prognostic techniques for HBV-associated HCC remains unrealized. The aim of the present study was to explore the efficacy of serum high-sensitivity C-reactive protein (hs-CRP) tests in the early diagnosis of HCC in patients with HBV-associated liver cirrhosis...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28511234/indications-results-and-clinical-impact-of-endoscopic-ultrasound-eus-guided-sampling-in-gastroenterology-european-society-of-gastrointestinal-endoscopy-esge-clinical-guideline-updated-january-2017
#6
Jean-Marc Dumonceau, Pierre H Deprez, Christian Jenssen, Julio Iglesias-Garcia, Alberto Larghi, Geoffroy Vanbiervliet, Guruprasad P Aithal, Paolo G Arcidiacono, Pedro Bastos, Silvia Carrara, László Czakó, Gloria Fernández-Esparrach, Paul Fockens, Àngels Ginès, Roald F Havre, Cesare Hassan, Peter Vilmann, Jeanin E van Hooft, Marcin Polkowski
For pancreatic solid lesions, ESGE recommends performing endoscopic ultrasound (EUS)-guided sampling as first-line procedure when a pathological diagnosis is required. Alternatively, percutaneous sampling may be considered in metastatic disease.Strong recommendation, moderate quality evidence.In the case of negative or inconclusive results and a high degree of suspicion of malignant disease, ESGE suggests re-evaluating the pathology slides, repeating EUS-guided sampling, or surgery.Weak recommendation, low quality evidence...
May 16, 2017: Endoscopy
https://www.readbyqxmd.com/read/28510280/modelling-the-iatrogenic-pancreatic-cancer-risk-after-islet-autotransplantation-in-mouse
#7
E Dugnani, V Pasquale, D Liberati, A Citro, E Cantarelli, S Pellegrini, P Marra, T Canu, G Balzano, M Scavini, A Esposito, C Doglioni, L Piemonti
Iatrogenic pancreatic cancer metastasis after islet infusion is a potential risk of islet autotransplantation performed after pancreatectomy. To model this risk islets and/or pancreatic exocrine clusters obtained from a genetically engineered mouse model for pancreatic ductal adenocarcinoma (the LSL-Kras(G12D/+) ;LSL-Trp53(R172H/+) ;Pdx-1-Cre, termed KPC mouse) were transplanted via the portal vein in syngeneic wild type (WT) severely diabetic recipients in the following treatment groups: group A (n=11) received KPC exocrine clusters in volume equal to 250 equivalent islets (IEQs); group B (n=12) received 250 WT IEQs mixed with KPC exocrine clusters (1:1 volume ratio); group C (n=5) received 250 KPC IEQs and group D (n=7) received 250 wild type IEQs...
May 16, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28508253/image-guided-transarterial-chemoembolization-with-drug-eluting-beads-loaded-with-doxorubicin-debdox-for-unresectable-hepatic-metastases-from-melanoma-technique-and-outcomes
#8
Jack Rostas, Alda Tam, Takami Sato, Larry Kelly, Cliff Tatum, Charles Scoggins, Kelly McMasters, Robert C G Martin
PURPOSE: Hepatic metastasis from melanoma represents a therapeutic dilemma, with limited effective options for the 85% of cases deemed unresectable. Systemic agents confer toxicity and, along with traditional local hepatic arterial-directed therapies such as transarterial chemoembolization, have not led to a significant increase in survival. The aim of this study was to investigate the safety and dose-limiting toxicity of DEBDOX for the treatment of unresectable hepatic metastases from melanoma...
May 15, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28501855/extracellular-ph-is-a-biomarker-enabling-detection-of-breast-cancer-and-liver-cancer-using-cest-mri
#9
Miaomiao Chen, Chaoying Chen, Zhiwei Shen, Xiaolei Zhang, Yanzi Chen, Fengfeng Lin, Xilun Ma, Caiyu Zhuang, Yifei Mao, Haochuan Gan, Peidong Chen, Xiaodan Zong, Renhua Wu
Extracellular pH (pHe) decrease is associated with tumor growth, invasion, metastasis, and chemoresistance, which can be detected by chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI). Here, we demonstrated that ioversol CEST MRI can be exploited to achieve pHe mapping of the liver cancer microenvironment. In in vitro studies, we firstly explored whether ioversol signal is pH-dependent, and calculated the function equation between the CEST effects of ioversol and pH values, in the range of 6...
April 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28497069/characterization-of-focal-liver-lesions-indistinctive-on-b-mode-ultrasound-benefits-of-contrast-enhanced-ultrasound
#10
Yi Dong, Feng Mao, Jiaying Cao, Peili Fan, Wen-Ping Wang
Aim. The aim of this prospective study was to evaluate the additional value of contrast-enhanced ultrasound (CEUS) in identifying and characterizing of focal liver lesions (FLLs) that are indistinctive on B mode ultrasound (BMUS). Methods. The study focused on 70 consecutive patients (male 46, female 24; mean age, 53.1 years ± 10). All lesions were detected by MRI but could not be clearly visualized by BMUS. CEUS was performed by injected SonoVue® (Bracco Imaging Spa, Milan, Italy) as a quick bolus into the antecubital vein...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28484824/prognostic-value-of-incidental-hypervascular-micronodules-detected-on-cone-beam-computed-tomography-angiography-of-patients-with-liver-metastasis
#11
Bruno C Odisio, Veronica L Cox, Silvana C Faria, Suguru Yamashita, Xiao Shi, Joe Ensor, Aaron K Jones, Armeen Mahvash, Sanjay Gupta, Alda L Tam, Jean-Nicolas Vauthey, Ravi Murthy
PURPOSE: To determine the clinical relevance of incidentally-found hypervascular micronodules (IHM) on cone-beam computed tomography angiography (CBCTA) in patients with liver metastasis undergoing transarterial (chemo)embolization (TACE/TAE). MATERIAL AND METHODS: This was a HIPAA-compliant institutional review board-approved single-institution retrospective review of 95 non-cirrhotic patients (52 men; mean age, 60 years) who underwent CBCTA prior to (chemo)embolic delivery...
May 8, 2017: European Radiology
https://www.readbyqxmd.com/read/28482388/-a-follow-up-report-of-childhood-hepatoblastoma-from-74-cases-in-a-single-center
#12
T Y Wang, C Pan, J Y Tang, Q D Ye, M Zhou, Y J Gao, W T Hu
Objective: To investigate the efficacy and the prognostic factors in pediatric hepatoblastoma according to the standard diagnostic and therapeutic regimen. Method: Eighty-four consecutive patients were enrolled in this study between June 2000 and June 2015. Diagnosis and staging was decided by the multi-disciplinary team including oncologists, surgeons, pathologists and sub-specialized radiologists refering to protocol of Children's Oncology Group(COG) and International Society of Pediatric Oncology Liver Tumor Study Group (SIOPEL) in a case observational study...
May 4, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28475013/evaluation-of-the-blood-supply-and-efficacy-of-transcatheter-arterial-chemoembolization-for-patients-with-liver-metastasis-using-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#13
Zu-Fei Wang, Xiao-Xi Fan, Min Xu, Min-Jiang Chen, Zhong-Wei Zhao, Jun-Dong Zhou, Jian-Fei Tu, Jing-Jing Song, Xiang-Hua Hu, Chen-Ying Lu, Fa-Zong Wu, Deng-Ke Zhang, Li Chen, Lu Liu, Xi-Hui Ying, Xiao-Fei Xu, Jian-Song Ji
Our study aims to evaluate the efficacy of transcatheter arterial chemoembolization in the treatment of patients with liver metastasis using integrated (18)F-fluorodeoxyglucose positron emission tomography/computed tomography. A total of 97 liver metastasis patients treated by transcatheter arterial chemoembolization were enrolled in this study. The (18)F-fluorodeoxyglucose positron emission tomography/computed tomography images of liver metastasis patients were collected before and after transcatheter arterial chemoembolization treatment...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28473915/long-term-complete-response-in-a-breast-cancer-patient-with-skeletal-muscle-metastases-diagnosed-using-18f-fdg-pet
#14
Diana Bello-Roufai, Daniele G Soares, Khaldoun Kerrou, Ahmed Khalil, Sandrine Richard, Joseph Gligorov, Jean-Pierre Lotz
Common sites for metastatic spreading from breast cancer are bones, lungs and liver, the skeletal muscle being an unusual site. Although rare, when skeletal muscle metastases occur they are associated with a poor prognosis. These metastases are clinically difficult to diagnose since they can be found without pain symptoms. Radiologically, magnetic resonance imaging has been considered better than computed tomography for imaging of the muscles and has been the first procedure to use in case of muscle metastasis suspicion...
February 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/28473088/acr-appropriateness-criteria-%C3%A2-suspected-liver%C3%A2-metastases
#15
Harmeet Kaur, Nicole M Hindman, Waddah B Al-Refaie, Hina Arif-Tiwari, Brooks D Cash, Victoria Chernyak, James Farrell, Joseph R Grajo, Jeanne M Horowitz, Michelle M McNamara, Richard B Noto, Aliya Qayyum, Tasneem Lalani, Ihab R Kamel
Liver metastases are the most common malignant liver tumors. The accurate and early detection and characterization of liver lesions is the key to successful treatment strategies. Increasingly, surgical resection in combination with chemotherapy is effective in significantly improving survival if all metastases are successfully resected. MRI and multiphase CT are the primary imaging modalities in the assessment of liver metastasis, with the relative preference toward multiphase CT or MRI depending upon the clinical setting (ie, surveillance or presurgical planning)...
May 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28470535/clinical-impact-of-cone-beam-computed-tomography-on-iterative-treatment-planning-during-ultrasound-guided-percutaneous-ablation-of-liver-malignancies
#16
Chiara Floridi, Alessandro Radaelli, Filippo Pesapane, Enrico Maria Fumarola, Michela Lecchi, Andrea Agostini, Andrea Giovagnoni, Gianpaolo Carrafiello, Bradford Wood
A standardized cone beam computed tomography (CBCT) protocol may impact optimal ablation probe(s) positioning during ultrasound-guided microwave ablation (MWA). To evaluate this hypothesis, 15 patients underwent ultrasound-guided percutaneous MWA of 15 liver lesions (10 hepatocellular carcinomas, 5 metastasis ranging 11-41 mm) with the ultrasound guidance assisted by a dedicated CBCT protocol. Pre-procedural enhanced CBCT (ceCBCT) was performed after intravenous contrast administration to visualize the lesion and determine the optimal approach using CBCT-based ablation planning software...
June 2017: Medical Oncology
https://www.readbyqxmd.com/read/28462646/primary-giant-aggressive-amelanotic-duodenal-melanoma
#17
R Kilambi, A N Singh, N R Dash, K S Madhusudhan, P Das
Primary malignant melanoma of the gastrointestinal tract is extremely rare. A 35-year-old man presented with complaints of abdominal pain and weight loss. Contrast enhanced computed tomography showed a large mass involving the duodenum and the superior mesenteric vessels. Upper gastrointestinal endoscopy demonstrated a large, friable mass along the duodenal wall and biopsy was suggestive of malignant melanoma. A detailed physical examination and whole body imaging (positron emission tomography and computed tomography) did not reveal any other lesion...
May 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28458594/hepatic-lesions-that-mimic-metastasis-on-radiological-imaging-during-chemotherapy-for-gastrointestinal-malignancy-recent-updates
#18
REVIEW
Sung-Hye You, Beom Jin Park, Yeul Hong Kim
During chemotherapy in patients with gastrointestinal malignancy, the hepatic lesions may occur as chemotherapy-induced lesions or tumor-associated lesions, with exceptions for infectious conditions and other incidentalomas. Focal hepatic lesions arising from chemotherapy-induced hepatopathies (such as chemotherapy-induced sinusoidal injury and steatosis) and tumor-associated eosinophilic abscess should be considered a mimicker of metastasis in patients with gastrointestinal malignancy. Accumulating evidence suggests that chemotherapy for gastrointestinal malignancy in the liver has roles in both the therapeutic effects for hepatic metastasis and injury to the non-tumor bearing hepatic parenchyma...
May 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/28455774/applications-of-fusion-fluorescence-imaging-using-indocyanine-green-in-laparoscopic-hepatectomy
#19
Muga Terasawa, Takeaki Ishizawa, Yoshihiro Mise, Yosuke Inoue, Hiromichi Ito, Yu Takahashi, Akio Saiura
BACKGROUND: Indocyanine green (ICG)-fluorescence imaging has been developed for real-time identification of hepatic tumors and segmental boundaries during hepatectomy. Fusion ICG-fluorescence imaging (real-time visualization of pseudocolor-fluorescence signals on white-light color images) may serve as a reliable navigation tool especially in laparoscopic hepatectomy, in which gross inspection and palpation are limited. METHODS: The study population consisted of 41 patients undergoing laparoscopic hepatectomy...
April 28, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28455622/focal-nodular-hyperplasia-that-mimicked-a-liver-metastasis-from-a-soft-tissue-sarcoma-a-case-report
#20
Masataka Amisaki, Soichiro Honjo, Noriyuki Iida, Satoshi Kuwamoto, Yoshiyuki Fujiwara
BACKGROUND: Imaging modalities (computed tomography (CT), ultrasonography, and magnetic resonance imaging (MRI)) have only limited ability to distinguish liver focal nodular hyperplasia (FNH) from metastatic liver tumors. Here, we report a patient who underwent surgery for benign FNH that mimicked a liver metastasis from soft tissue sarcoma (STS). CASE PRESENTATION: A 23-year-old man with a history of several surgeries for metastatic abdominal STS, developed a hepatic tumor accompanying peritoneal STS recurrence...
December 2017: Surgical Case Reports
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