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Liver metastasis imaging

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https://www.readbyqxmd.com/read/27905289/cerebral-alveolar-echinococcosis-concomitant-with-liver-and-lung-lesions-in-a-young-adult-patient-case-report-and-literature-review
#1
Osman Ersegun Batçık, Ahmet Öğrenci, Orkun Koban, Murat Şakir Ekşi, Turgay Bilge
We present the case of a 25-year-old male harboring multiple brain lesions mimicking tumor metastasis that were revealed to be caused by Echinococcus multilocularis. Cerebral echinococcosis with multiple lesions is rare and might be confused with a brain abscess, tuberculoma, or metastatic tumor disease. Brain magnetic resonance imaging and serological studies are helpful in the differential diagnosis. In case of E. multilocularis, cerebral invasion is the late stage of the disease that necessitates an aggressive treatment protocol...
September 2016: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/27904130/solitary-metastasis-to-a-distant-lymph-node-in-the-descending-mesocolon-after-primary-resection-for-hepatocellular-carcinoma-is-surgical-resection-valid
#2
Yuki Aisu, Hiroaki Furuyama, Tomohide Hori, Takafumi Machimoto, Toshiyuki Hata, Yoshio Kadokawa, Shigeru Kato, Yasuhisa Ando, Yuichiro Uchida, Daiki Yasukawa, Yusuke Kimura, Maho Sasaki, Yuichiro Takamatsu, Tunehiro Yoshimura
BACKGROUND Lymph node metastasis of hepatocellular carcinoma is rare, and lymph nodes located on hepatic hilar and hepatoduodenal ligaments are primary targets. Metastasis to a mesocolic lymph node has not been reported previously. CASE REPORT A 65-year-old woman with liver cirrhosis underwent primary resection of hepatocellular carcinoma. Two and a half years later, tumor marker levels increased remarkably and imaging revealed a mesocolic mass. The tumor measured 27 mm in diameter and showed characteristic findings consistent with hepatocellular carcinoma in dynamic computed tomographic images, although the tumor was negative in fluorine-18-fluorodeoxyglucose positron emission tomographic images...
December 1, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27871163/a-case-of-endoscopically-complete-remission-of-esophageal-neuroendocrine-tumors-by-concurrent-chemoradiation-therapy
#3
Myung Hee Kim, Hyun Yong Jeong, Jae Kyu Seong, Hee Seok Moon, Sun Hyung Kang, Duk Ki Kim
Neuroendocrine tumors (NETs) of the esophagus are extremely rare, aggressive and have a poor prognosis. Combined therapy using chemotherapy, radiotherapy and/or surgery appear effective. Here, we present a patient with a complaint of dysphagia who was diagnosed with this rare tumor. Upper gastrointestinal endoscope of a 46-year-old female revealed a localized ulcerative lesion in the middle esophagus. Histologic exam of biopsy specimens indicated a neuroendocrine carcinoma. The tumor cells were arranged in microtubular structures, with small and round cells containing scanty cytoplasm...
November 25, 2016: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/27864816/giant-insulinoma-report-of-a-case-and-review-of-published-reports
#4
Kazumitsu Ueda, Tetsuro Taira, Hiroyuki Hakoda, Shoko Nakata, Shinya Okata, Takeshi Nagai, Shigeo Aoki, Hideyuki Mishima, Akihiko Sako, Tsunehiko Maruyama, Minoru Okumura
BACKGROUND: Larger insulinomas are reportedly more likely to be malignant; however, their biological behavior has not been clearly elucidated. We here report the characteristics and treatment of a giant insulinoma with local invasion and lymph node metastasis. We also review published reports concerning the clinical features of giant insulinomas and comparing their grading with that of pancreatic neuroendocrine tumors. CASE PRESENTATION: A 71-year-old man was referred to our hospital for investigation of persistent hypoglycemia...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27861987/comparison-of-contrast-enhanced-ultrasonograpy-with-gd-eob-dtpa-enhanced-mri-in-the-diagnosis-of-liver-metastasis-from-colorectal-cancer
#5
Kazue Shiozawa, Manabu Watanabe, Takashi Ikehara, Yasushi Matsukiyo, Michio Kogame, Yoshinori Kikuchi, Yuichiro Otsuka, Hironori Kaneko, Yoshinori Igarashi, Yasukiyo Sumino
PURPOSE: To compare contrast-enhanced ultrasonography (CEUS) using Sonazoid with Gd-EOB-DTPA-enhanced MRI (EOB-MRI) in the diagnosis of liver metastases in patients with colorectal cancer. METHODS: A total of 69 patients diagnosed with or suspected of having liver metastasis were enrolled. These hepatic lesions were diagnosed by histopathological examination after surgical resection or based on follow-up using various imaging modalities. The diagnostic accuracies of CEUS and EOB-MRI were compared...
November 12, 2016: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/27822263/focal-sinusoidal-obstruction-syndrome-caused-by-oxaliplatin-induced-chemotherapy-a-case-report
#6
Takaharu Kawai, Shintaro Yamazaki, Atsuko Iwama, Tokio Higaki, Masahiko Sugitani, Tadatoshi Takayama
INTRODUCTION: Sinusoidal obstruction syndrome (SOS) is a severe adverse event of long-term chemotherapy in patients with colorectal cancer. It usually develops as liver congestion due to diffuse microscopic obstruction in liver parenchyma. In contrast, it sometimes appears as a liver mass occurring with local parenchymal hemorrhaging, and is often misdiagnosed as liver metastasis. CASE PRESENTATION: A 40-year-old woman with rectal cancer underwent high anterior resection and partial liver resection of segment 7 due to synchronous liver metastasis...
September 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/27812769/use-of-non-invasive-imaging-to-monitor-response-to-aflibercept-treatment-in-murine-models-of-colorectal-cancer-liver-metastases
#7
Karianne G Fleten, Kine M Bakke, Gunhild M Mælandsmo, Andreas Abildgaard, Kathrine Røe Redalen, Kjersti Flatmark
The liver is the most frequent metastatic site in colorectal cancer (CRC), and relevant orthotopic in vivo models are needed to study the efficacy of anticancer drugs in the metastatic setting. A challenge when utilizing such models is monitoring tumor growth during the experiments. In this study, experimental liver metastases were established in nude mice by splenic injection of the CRC cell lines HT29 and HCT116, and the mice were treated with the antiangiogenic drug aflibercept. Tumor growth was monitored using magnetic resonance imaging (MRI) and bioluminescence imaging (BLI)...
November 3, 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27807951/complete-remission-of-liver-metastasis-in-a-lung-cancer-patient-with-epidermal-growth-factor-mutation-achieved-with-icotinib
#8
Zhouyu Zhu, Ying Chai
A 65-year-old Chinese male was referred to our hospital for epidermal growth factor receptor (EGFR)-mutated advanced non-small cell lung cancer (NSCLC). Aggressive combined therapy with surgical resection of the right upper lung lesion and chemotherapy was performed. One month later, continued Icotinib treatment was used as magnetic resonance imaging revealed liver metastasis (LM). Interestingly, complete remission of the patient's LM lesions was achieved in six months. To our knowledge, this is the first report documenting a successful case of an NSCLC patient with LM treated with Icotinib after receiving a radical resection for pulmonary carcinoma...
November 2016: Thoracic Cancer
https://www.readbyqxmd.com/read/27803830/hepatoid-adenocarcinoma-of-the-urachus
#9
Daniel Fernando Gallego, Carlos Muñoz, Carlos Andrés Jimenez, Edwin Carrascal
Hepatoid adenocarcinoma of the urachus is a rare condition. We present the case of a 51-year-old female who developed abdominal pain and hematuria. Pelvic magnetic resonance imaging (MRI) reported an urachal mass with invasion to the bladder that was resected by partial cystectomy. On light microscopy the tumor resembled liver architecture, with polygonal atypical cells in nest formation and trabecular structures. Immunochemistry was positive for alfa-fetoprotein (AFP) and serum AFP was elevated. Hepatoid adenocarcinomas have been reported in multiple organs, being most commonly found in the stomach and the ovaries...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27796544/the-intensity-of-18fdg-uptake-does-not-predict-tumor-growth-in-patients-with-metastatic-differentiated-thyroid-cancer
#10
Marie Terroir, Isabelle Borget, François Bidault, Marcel Ricard, Frédéric Deschamps, Dana Hartl, Lambros Tselikas, Laurent Dercle, Jean Lumbroso, Eric Baudin, Amandine Berdelou, Désirée Deandreis, Martin Schlumberger, Sophie Leboulleux
PURPOSE: In patients with metastatic differentiated thyroid carcinoma (DTC), fluorodeoxyglucose (FDG) uptake as well as age, tumor size and radioactive iodine (RAI) uptake are prognostic factors for survival. High FDG uptake is a poor prognostic factor and lesions with high FDG uptake are often considered aggressive, but the predictive value of FDG uptake for morphological progression is unknown. The principal aim of this retrospective single center study was to determine whether the intensity of FDG uptake was correlated on a per lesion analysis with tumor growth rate (TGR) expressed as the percentage of increase in tumor size during 1 year (1-year TGR)...
October 29, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27788726/-clinical-features-of-malignant-tumor-liver-infiltration-with-liver-failure-as-initial-clinical-manifestation-a-single-center-retrospective-analysis-of-9-cases
#11
J P Liu, H B Ning, K Li, M Y Zhang, W Li, C S Mao, H W Wu, Y Kang, J Shang
Objective: To investigate the clinical features of patients with liver failure caused by tumor diffuse liver infiltration. Methods: A retrospective analysis was performed for the clinical data of 1008 patients with liver failure who were admitted to our hospital from July 2009 to December 2015. Among these patients, 9 had acute liver failure caused by liver metastasis of malignant tumor. Their clinical manifestations, laboratory markers, clinical progress, and outcome were observed, and the clinical features were summarized...
September 20, 2016: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/27785973/hepatic-radiation-injury-mimicking-metastasis-in-distal-esophageal-cancer
#12
Karel Demey, Hans Van Veer, Philippe Nafteux, Christophe M Deroose, Karin Haustermans, Johan Coolen, Vincent Vandecaveye, Willy Coosemans, Eric Van Cutsem
INTRODUCTION: A new hypermetabolic lesion on (18)FDG-PET/CT after neo-adjuvant chemoradiotherapy for distal esophageal cancer can be a hepatic metastasis and should be examined carefully before esophagectomy. CASE-REPORT: We present a case of acute and nodular radiation-induced injury of the left liver after neo-adjuvant chemoradiotherapy for distal esophageal cancer, which resembles a hepatic metastasis on (18)FDG-PET/CT. Acute and nodular radiation hepatitis (RH) can be a potential cause of false-positive findings of malignancy and therefore exclude patients who could benefit from esophagectomy...
October 27, 2016: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/27783272/periportal-low-attenuation-associated-with-liver-metastasis-from-colorectal-cancer-evaluation-using-multi-detector-row-ct-with-pathological-correlation
#13
Ryo Takaji, Shunro Matsumoto, Maki Kiyonaga, Yasunari Yamada, Hiromu Mori, Yukio Iwashita, Masayuki Ohta, Masafumi Inomata, Naoki Hijiya, Masatsugu Moriyama, Hajime Takaki, Kengo Fukuzawa, Hirotoshi Yonemasu
OBJECTIVES: Periportal low attenuation (PPLA) associated with metastatic liver cancer is occasionally seen on multi-detector-row CT (MDCT). The purpose of this study was to investigate the MDCT patterns of the PPLA and to correlate it with pathological findings. METHODS: We retrospectively reviewed the MDCT images of 63 patients with metastatic liver cancers from colorectal adenocarcinoma. On MDCT scans, PPLA associated with liver metastasis was visualized in six patients with colorectal cancer...
October 25, 2016: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/27781248/-application-of-multidisciplinary-treatment-in-patients-with-liver-metastasis-of-colorectal-cancer
#14
Hao Li, Xiaohui Du, Shaoyou Xia, Songyan Li, Jian Xu, Guijun Zou, Shidong Hu
OBJECTIVE: To evaluate the application of multidisciplinary treatment (MDT) in patients with liver metastasis of colorectal cancer(CLM). METHODS: Clinical data of 118 patients with liver metastasis of colorectal cancer, including 32 patients with MDT (MDT group) and 86 patients without MDT (control group), from February 2014 to April 2015 in PLA General Hospital were analyzed retrospectively. Compliance of preoperative examination and adjuvant therapy, and efficacy-associated indexes were compared between the two groups...
October 25, 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27775935/pet-ct-as-an-alternative-to-fiducial-markers-guidance-in-liver-metastasis-treatment
#15
Fernanda Granato, Andre C Felicio, Lilian Yuri Itaya Yamaga, Solange Amorim Nogueira, Taise Vitor
The liver is the organ most commonly affected by colorectal cancer metastasis. Currently, liver resection is the treatment of choice, but in cases where it is not possible, intensity-modulated radiation therapy is an alternative. We report the case of a 57-year-old woman whose colorectal carcinoma metastasized to the liver. She was referred for implantation of fiducial markers for intensity-modulated radiation therapy planning. PET-CT stands out as an additional tool for distinguishing metabolically active tumor tissue from other tissues, ensuring effective introduction of percutaneous fiducial markers, especially in cases where use of conventional imaging techniques is limited...
October 21, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27768066/long-term-high-resolution-intravital-microscopy-in-the-lung-with-a-vacuum-stabilized-imaging-window
#16
Carolina Rodriguez-Tirado, Takanori Kitamura, Yu Kato, Jeffery W Pollard, John S Condeelis, David Entenberg
Metastasis to secondary sites such as the lung, liver and bone is a traumatic event with a mortality rate of approximately 90% (1). Of these sites, the lung is the most difficult to assess using intravital optical imaging due to its enclosed position within the body, delicate nature and vital role in sustaining proper physiology. While clinical modalities (positron emission tomography (PET), magnetic resonance imaging (MRI) and computed tomography (CT)) are capable of providing noninvasive images of this tissue, they lack the resolution necessary to visualize the earliest seeding events, with a single pixel consisting of nearly a thousand cells...
October 6, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27764803/cd133-cd54-cd44-circulating-tumor-cells-as-a-biomarker-of-treatment-selection-and-liver-metastasis-in-patients-with-colorectal-cancer
#17
Chao Fang, Chuanwen Fan, Cun Wang, Qiaorong Huang, Wentong Meng, Yongyang Yu, Lie Yang, Zhihai Peng, Jiankun Hu, Yuan Li, Xianming Mo, Zongguang Zhou
INTRODUCTION: Liver is the most common site of distant metastasis in colorectal cancer (CRC). Early diagnosis and appropriate treatment selection decides overall prognosis of patients. However, current diagnostic measures were basically imaging but not functional. Circulating tumor cells (CTCs) known as hold the key to understand the biology of metastatic mechanism provide a novel and auxiliary diagnostic strategy for CRC with liver metastasis (CRC-LM). RESULTS: The expression of CD133+ and CD133+CD54+CD44+ cellular subpopulations were higher in the peripheral blood of CRC-LM patients when compared with those without metastasis (P<0...
October 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27762594/metastatic-patterns-of-solitary-fibrous-tumors-a-single-institution-experience
#18
Ailbhe C O'Neill, Sree Harsha Tirumani, Woo S Do, Abhishek R Keraliya, Jason L Hornick, Atul B Shinagare, Nikhil H Ramaiya
OBJECTIVE: The objective of our study was to evaluate the metastatic patterns and imaging features of solitary fibrous tumors (SFTs). MATERIALS AND METHODS: This retrospective study included 139 patients with pathologically proven SFT, 49 of whom developed metastases. Electronic medical records and all available images were reviewed to record the pattern and imaging appearances of metastatic disease, and comparisons of thoracic SFTs and extrathoracic SFTs were also performed...
October 20, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27761301/occult-primary-neuroendocrine-tumor-metastasis-to-the-breast-detected-on-screening-mammogram
#19
Fabiana Policeni, Brittany Pakalniskis, Limin Yang
Metastatic tumors are rare in the breast. Well-differentiated neuroendocrine tumors (WDNETs) are slow-growing neoplasms that arise from neuroendocrine cells, particularly in the gastrointestinal tract and bronchial tree. Metastatic WDNET to the breast is a rare entity. We present a case report of ileal WDNET metastatic to the breast which was initially identified as a small mass in the patient's left breast on screening mammography. Targeted ultrasound identified a suspicious mass, and ultrasound-guided percutaneous core biopsy was performed...
2016: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/27760789/the-biodistribution-and-immune-suppressive-effects-of-breast-cancer-derived-exosomes
#20
Shu Wen Wen, Jaclyn Sceneay, Luize Goncalves Lima, Christina S F Wong, Melanie Becker, Sophie Krumeich, Richard J Lobb, Vanessa Castillo, Ke Ni Wong, Sarah Ellis, Belinda S Parker, Andreas Möller
Small membranous secretions from tumor cells, termed exosomes, contribute significantly to intercellular communication and subsequent reprogramming of the tumor microenvironment. Here, we use optical imaging to determine that exogenously administered fluorescently labeled exosomes derived from highly metastatic murine breast cancer cells distributed predominantly to the lung of syngeneic mice, a frequent site of breast cancer metastasis. At the sites of accumulation, exosomes were taken up by CD45(+) bone marrow-derived cells...
December 1, 2016: Cancer Research
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