Serena Delbue, Elena Pariani, Silvia Parapini, Cristina Galli, Nicoletta Basilico, Sarah D'Alessandro, Sara Pellegrino, Elena Pini, Samuele Ciceri, Patrizia Ferraboschi, Paride Grisenti
Lysozyme (E.C. 3.2.1.17), an about 14 kDa protein and pI 11, widely spread in nature, is present in humans mainly in milk, saliva, and intestinal mucus as a part of innate defense mechanisms. It is endowed with antimicrobial activity due to its action as an N-acetylmuramidase, cleaving the 1-4β glycosidic linkage in the peptidoglycan layer of Gram-positive bacteria. This antimicrobial activity is exerted only against a limited number of Gram-negative bacteria. Different action mechanisms are proposed to explain its activity against Gram-negative bacteria, viruses, and fungi...
March 21, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry