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https://www.readbyqxmd.com/read/29233628/xanthogranulomatous-pyelonephritis-in-a-paediatric-cohort-1963-2016-outcomes-from-a-large-single-center-series
#1
I Stoica, F O'Kelly, M B McDermott, F M J Quinn
BACKGROUND: Xanthogranulomatous pyelonephritis (XGP) is an uncommon chronic destructive granulomatous inflammation of the kidney. It was first described in 1916, and is thought to affect 6/1000 cases of pyelonephritis. Its manifestations are varied, and with a limited number of cases in the literature, the optimal diagnosis and management of XGP in the paediatric cohort is still unknown. MATERIAL AND METHODS: The medical records of children who were diagnosed and treated for XGP at the current unit during the period 1963-2016, inclusive, were retrospectively reviewed...
November 24, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29223716/alkaline-degradation-of-lyophilized-dmsa-prior-to-labeling-with-99mtc-identification-and-development-of-the-degradation-pathway-by-hplc-and-ms
#2
Erika V Almeida, Samuel L De Brito
INTRODUCTION: Complexes of technetium-99m (99mTc) with meso-dimercaptosuccinic acid (DMSA) have been widely used as diagnostic agents in nuclear medicine. The degradation products (DP) of DMSA formed under different forced conditions have been identified through HPLC-DAD and LC-MSn studies. In this study, the DMSA kit was subjected to forced degradation under hydrolysis conditions as prescribed by the International Conference on Harmonization (ICH) guideline Q1A. METHODS: Chromatographic separation was accomplished on a reverse phase Shim-Pack VP-ODS (150 mm × 4...
November 10, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29218427/the-role-of-nonautologous-and-autologous-adipose-derived-mesenchymal-stem-cell-in-acute-pyelonephritis
#3
Shabnam Sabetkish, Nastaran Sabetkish, Mahba Ataei Talebi, Shahnaz Halimi, Abdol-Mohammad Kajbafzadeh
We compared the therapeutic effects of autologous and nonautologous adipose-derived mesenchymal stem cell (ADMSC), in ameliorating the renal function in a rabbit model of acute pyelonephritis. The difference of perirenal and neck subcutaneous ADMSCs were also evaluated. Twenty female rabbits were apportioned to 5 groups. In group I (n = 4), the rabbits were injected direct inoculation of Escherichia coli (E. coli) into the right kidney. In group II (n = 4), autologous ADMSCs obtained from nape adipose tissue were injected into the subcapsular space 1 week after E...
December 7, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/29211403/the-role-of-fetal-maternal-microchimerism-as-a-natural-born-healer-in-integrity-improvement-of-maternal-damaged-kidney
#4
Abdol-Mohammad Kajbafzadeh, Shabnam Sabetkish, Nastaran Sabetkish
PURPOSE: To identify the fetal stem cell (FSC) response to maternal renal injury with emphasis on renal integrity improvement and Y chromosome detection in damaged maternal kidney. MATERIALS AND METHODS: Eight non-green fluorescent protein (GFP) transgenic Sprague- Dawley rats were mated with GFP-positive transgenic male rats. Renal damage was induced on the right kidney at gestational day 11. The same procedure was performed in eight non-pregnant rats as control group...
December 7, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29204797/prevention-of-renal-scarring-in-acute-pyelonephritis-by-probiotic-therapy-an-experimental-study
#5
Nastaran Sabetkish, Shabnam Sabetkish, Mohammad Javad Mohseni, Abdol-Mohammad Kajbafzadeh
We evaluated the protective effects of probiotic administration as a prophylaxis treatment and immediately after fever onset in increasing the immune response and decreasing the renal scarring in a rat model of acute pyelonephritis. Twenty-four rats were apportioned to three groups. In GI (n = 8), the rats were injected with direct inoculation of Escherichia coli into the right kidney. In GII (n = 8), the rats received a probiotic regimen 1 month before E. coli injection and the probiotic regimen was continued for the next 2 months...
December 4, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29187904/multimodality-imaging-of-angiogenesis-in-a-rabbit-atherosclerotic-model-by-gebp11-peptide-targeted-nanoparticles
#6
Tao Su, Ya-Bin Wang, Dong Han, Jing Wang, Shun Qi, Lei Gao, Ya-Hui Shao, Hong-Yu Qiao, Jiang-Wei Chen, Shu-Hui Liang, Yong-Zhan Nie, Jia-Yi Li, Feng Cao
Background and Aims: Angiogenesis is an important pathological process during progression of plaque formation, which can result in plaque hemorrhage and vulnerability. This study aims to explore non-invasive imaging of angiogenesis in atherosclerotic plaque through magnetic resonance imaging (MRI) and positron emission tomography (PET) by using GEBP11 peptide targeted magnetic iron oxide nanoparticles in a rabbit model of atherosclerosis. Methods: The dual-modality imaging probe was constructed by coupling 2, 3-dimercaptosuccinnic acid-coated paramagnetic nanoparticles (DMSA-MNPs) and the PET 68Ga chelator 1,4,7-triazacyclononane-N, N', N''-triacetic acid (NOTA) to GEBP11 peptide...
2017: Theranostics
https://www.readbyqxmd.com/read/29164462/ameliorative-effect-of-the-anticancer-agent-salinomycin-on-cadmium-induced-hepatotoxicity-and-renal-dysfunction-in-mice
#7
Kalina Kamenova, Yordanka Gluhcheva, Ivelin Vladov, Silviya Stoykova, Juliana Ivanova
This study presents experimental data on the effects of the tetraethylammonium salt of salinomycinic acid (Sal) on Cd-induced hepatotoxicity and renal dysfunction in Cd-treated mice compared to those of meso-2,3-dimercaptosuccinic acid (DMSA). Forty 60-day-old male ICR mice were randomized into five groups: control group (untreated mice), Cd group (Cd(II) acetate 20 mg/kg body weight provided orally once per day for 14 days), Cd + DMSA group (exposed to Cd(II) acetate as the Cd-exposed group followed by DMSA 20 mg/kg body weight provided orally once per day for 14 days), and Cd + Sal group (exposed to Cd(II) acetate as the Cd-exposed group followed by Sal 20 mg/kg body weight once per day for 14 days)...
November 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29144626/super-selective-robot-assisted-partial-nephrectomy-using-near-infrared-flurorescence-versus-early-unclamping-of-the-renal-artery-results-of-a-prospective-matched-pair-analysis
#8
Cecilia Lanchon, Valentin Arnoux, Gaëlle Fiard, Jean-Luc Descotes, Jean-Jacques Rambeaud, Jean-Benjamin Lefrancq, Delphine Poncet, Nicolas Terrier, Camille Overs, Quentin Franquet, Jean-Alexandre Long
INTRODUCTION: Super-selective clamping of tumor-specific segmental arteries was developed to eliminate ischemia of the remnant kidney while limiting hemorrhage during partial nephrectomy. The objective is to evaluate the benefice of super-selective clamping on renal functional outcome, compared to early-unclamping of the renal artery. MATERIALS AND METHODS: From March 2015 to July 2016, data from 30 patients undergoing super-selective robot-assisted PN (RAPN) for a solitary tumor by a single surgeon were prospectively collected...
November 19, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29142969/elucidation-of-renal-scars-in-children-with%C3%A2-vesicoureteral-reflux-using-contrast-enhanced-ultrasound-a-pilot%C3%A2-study
#9
David S Hains, Harris L Cohen, M Beth McCarville, Ellen E Ellison, Amy Huffman, Stacey Glass, Aslam H Qureshi, Keith R Pierce, Ashlyn L Cahill, Ashley Dixon, Noel Delos Santos
Introduction: Vesicoureteral reflux is a common disorder in children but can result in kidney scarring following acute pyelonephritis. The gold standard diagnostic to detect renal scars in children is (99m)Tc-dimercaptosuccinic acid (DMSA) scintigraphy. DMSA has a number of limitations including radiation exposure, need for sedation, and radiotracer supply shortages. Contrast-enhanced ultrasound (CEUS) is a technique whereby biocompatible microspheres of inert gas are administered i.v...
May 2017: KI Reports
https://www.readbyqxmd.com/read/29125524/expectant-use-of-cic-in-newborns-with-spinal-dysraphism-report-of-clinical-outcomes
#10
Matthew D Timberlake, Adam J Kern, Richard Adams, Candice Walker, Bruce J Schlomer, Micah A Jacobs
PURPOSE: Report urologic outcomes among newborns with spinal dysraphism managed within an expectant clean intermittent catheterization (CIC) program. METHODS: Newborns were followed clinically and with serial ultrasound (US). Urodynamics (UD) and dimercaptosuccinic acid (DMSA) renal scan were obtained at 3-6 months, 1 year, 3 years, then as needed. Patients with initial evaluation after 6 months were excluded. RESULTS: Median follow-up was 3...
October 20, 2017: Journal of Pediatric Rehabilitation Medicine
https://www.readbyqxmd.com/read/29100793/discrimination-of-culture-negative-pyelonephritis-in-children-with-suspected-febrile-urinary-tract-infection-and-negative-urine-culture-results
#11
Jun Ho Lee
BACKGROUND: We investigated whether the C-reactive protein (CRP) level, urine electrolytes, and urine sodium-potassium ratio (uNa/K) could be useful markers for discriminating children with culture negative pyelonephritis (CNP) from children with suspected febrile urinary tract infection (fUTI) and negative urine culture results. METHODS: We examined 264 children experiencing their first fUTI consecutively admitted to our hospital between January 2011 and October 2014...
October 25, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/29093113/availability-of-99m-tc-dmsa
#12
Justin Paolino, S Ted Treves
No abstract text is available yet for this article.
November 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29090653/tuberculous-pyelonephritis-in-children-three-case-reports
#13
Nimisha Arora, Abhijeet Saha, Manpreet Kaur
Tuberculous pyelonephritis is rare in children; three case reports are presented. Case 1 was an 11-year-old girl with a previous history of pulmonary tuberculosis who presented with flank pain and fever for 10 days. An ultrasound suggested focal pyelonephritis, and a contrast-enhanced computed tomography (CECT) scan demonstrated acute focal pyelonephritis and a perinephric collection. Mycobacterium tuberculosis was cultured in the urine. She responded well to anti-tuberculous treatment (ATT). Case 2 was a 13-year-old boy who presented with fever, haematuria, burning micturition, proteinuria (3+) and cervical lymphadenopathy...
November 1, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/29063135/metal-chelators-and-neurotoxicity-lead-mercury-and-arsenic
#14
REVIEW
Geir Bjørklund, Joachim Mutter, Jan Aaseth
This article reviews the clinical use of the metal chelators sodium 2,3-dimercapto-1-propanesulfonate (DMPS), meso-2,3-dimercaptosuccinic acid (DMSA), and calcium disodium edetate (CaEDTA, calcium EDTA) in overexposure and poisonings with salts of lead (Pb), mercury (Hg), and arsenic (As). DMSA has considerably lower toxicity than the classic heavy metal antagonist BAL (2,3-dimercaptopropanol) and is also less toxic than DMPS. Because of its adverse effects, CaEDTA should be replaced by DMSA as the antidote of choice in treating moderate Pb poisoning...
October 24, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28994595/pertechnetate-induced-addition-of-sulfide-in-small-olefinic-acids-formation-of-tco-dimercaptosuccinate-2-5-and-tco-mercaptosuccinate-2-3-analogues
#15
Kimberly M Reinig, Rachel Seibert, Daniel Velazquez, Jakob Baumeister, Firouzeh Najafi Khosroshahi, Wei Wycoff, Jeff Terry, John E Adams, Carol A Deakyne, Silvia S Jurisson
Technetium-99 ((99)Tc) is important to the nuclear fuel cycle as a long-lived radionuclide produced in ∼6% fission yield from (235)U or (239)Pu. In its most common chemical form, namely, pertechnetate ((99)TcO4(-)), it is environmentally mobile. In situ hydrogen sulfide reduction of pertechnetate has been proposed as a potential method to immobilize environmental (99)TcO4(-) that has entered the environment. Reactions of (99)TcO4(-) with sulfide in solution result in the precipitation of Tc2S7 except when olefinic acids, specifically fumaric or maleic acid, are present; a water-soluble (99)Tc species forms...
November 6, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28984254/yield-of-imaging-performed-as-per-indian-society-of-pediatric-nephrology-guidelines-in-children-with-urinary-tract-infection
#16
Rajiv Sinha, Devdeep Mukherjee, Jayati Sengupta, Subhasis Saha, Sushmita Banerjee
OBJECTIVE: To assess yield of imaging performed as per Indian Society of Pediatric Nephrology (ISPN) urinary tract infection (UTI) guideline. METHODS: Ultrasonography (USG), voiding cystourethrography (VCUG) and dimercaptosuccinic-acid (DMSA) scintigraphy were performed in 183 children (age 0-5y) with first episode (age 0-1y) of UTI or recurrent (age <5y) UTI, as per ISPN recommendations. RESULTS: Significant abnormalities were detected in 110 (63%), with vesicoureteric reflux (VUR) grades 3-5 in 31% and renal scars in 43%...
September 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28982546/what-did-we-find-from-imaging-studies-in-childhood-uti-and-which-studies-are-mandatory
#17
Prayong Vachvanichsanong, Pornsak Dissaneewate, Edward McNeil
OBJECTIVE: To evaluate the imaging results of childhood UTI in our setting, and examine if it would be appropriate to apply the recent guideline changes regarding imaging studies as routine practice in Thailand. METHODS: Medical records of UTI children aged 0-15 years were reviewed, with focus on renal ultrasound (RUS), cystogram and (99mTc)dimercaptosuccinic acid (DMSA) renal scan results to determine congenital anomalies of the kidney and urinary tract (CAKUT) and renal damage...
October 2, 2017: Urology
https://www.readbyqxmd.com/read/28981712/patient-specific-dosimetry-for-pediatric-imaging-of-99mtc-dimercaptosuccinic-acid-with-gate-monte-carlo-code
#18
Mahmoud Bagheri, Ali Asghar Parach, Seid Kazem Razavi-Ratki, Reza Nafisi-Moghadam, Mohammad Ali Jelodari
In this study, radiation absorbed dose of 99mTc-dimercaptosuccinic acid (DMSA) in critical organs was calculated using Monte Carlo simulation. Ten child patients with genitourinary abnormalities were imaged using a series of planar, SPECT and MRI, after injection with 99mTc-DMSA. Patient-specific organ segmentation was performed on MRI and used as input in GATE. Organs with substantial uptake included kidneys, bladder and liver. The mean organ absorbed dose coefficients (mGy/MBq) were 0.063, 0.058, 0.018, 0...
August 5, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28979776/usefulness-of-99m-tc-dimercaptosuccinic-acid-renal-scan-in-the-diagnosis-and-follow-up-of-acute-tubulointerstitial-nephritis-in-children
#19
Enrico Vidal, Elisabetta Miorin, Pietro Zucchetta, Elisa Benetti, Germana Longo, Davide Meneghesso, Mattia Parolin, Luisa Murer
BACKGROUND: Symptoms and signs of acute tubulointerstitial nephritis (ATIN) are nonspecific; therefore, renal biopsy is often necessary to clarify the diagnosis. The aim of this study was to evaluate the use of (99m)Tc-dimercaptosuccinic acid (DMSA) scintigraphy in the diagnosis and follow-up of ATIN. METHODS: We retrospectively reviewed the charts of five patients (nine renal units) with a median age of 14 years who underwent DMSA scan after a clinical and/or biopsy-proven diagnosis of ATIN...
October 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28965578/synthesis-and-characterization-of-new-1-hydroxy-2-pyridinethione-derivatives-their-lead-complexes-and-efficacy-in-the-treatment-of-acute-lead-poisoning-in-rats
#20
Manal H Al Khabbas, Samah A Ata, Kamal I Abu-Dari, Maha F Tutunji, Mohammad S Mubarak
A number of new mono- and dihydroxypyridinethione ligands have been synthesized via reaction of dimethylamine and amino acid esters with the active amide obtained from the reaction of 1-hydroxy-2-pyridinethione-4-carboxylic acid (1) and 1,1'-carbonyldiimidazole in DMF. Moreover, the lead complexes of these new ligands were also prepared. Structures of the newly synthesized compounds have been confirmed by different spectroscopic methods such as IR, (1)H NMR, and (13)C NMR, and by elemental analysis. The effect of these synthesized ligands on the excretion of lead, iron, and zinc, and their distribution in kidneys, liver, and bones in acutely intoxicated rats was investigated and results, for lead, were compared with those of the known drug meso-2,3-dimercaptosuccinic acid (DMSA)...
December 2017: Journal of Trace Elements in Medicine and Biology
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