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https://www.readbyqxmd.com/read/28637056/-urosepsis-in-children
#1
Josef Oswald
Urinary tract infections (UTI) are the most common infectious diseases in children. Urosepsis in childhood, though rare, is the most complicated possible variant. In newborns and infants, unspecific symptoms are a significant barrier to a fast and reliable diagnosis, which is crucial to successful treatment. In addition to urine and laboratory tests as well as non-invasive examinations (ultrasound), there may be an indication for invasive examinations of the kidneys (DMSA scans) in cases of a severe infection...
June 21, 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28612056/critical-appraisal-of-the-top-down-approach-for-vesicoureteral-reflux
#2
REVIEW
Ahmed Abdelhalim, Antoine E Khoury
Vesicoureteral reflux (VUR) has been linked to recurrent urinary tract infections (UTIs), renal scarring, hypertension, renal insufficiency and end-stage kidney disease. Different imaging strategies have been proposed to approach children presenting with UTI to sort out patients with significant VUR while minimizing patient morbidity, radiation exposure and financial burden. None of these imaging strategies is universally accepted. The"top-down approach" (TDA) aims at restricting the number of voiding cystourethrograms (VCUGs) and its associated morbidity while identifying patients with clinically-significant reflux...
June 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28605996/in-vitro-exposure-of-bull-sperm-cells-to-dmsa-coated-maghemite-nanoparticles-does-not-affect-cell-functionality-or-structure
#3
Denise Ferreira Caldeira, Fernanda Paulini, Renata Carvalho Silva, Ricardo Bentes de Azevedo, Carolina Madeira Lucci
Magnetic nanoparticles can be used in different areas of biology. It is therefore important to know the effects of such nanomaterials on germline cells as they may traverse the blood-testis barrier. This work aimed to evaluate the response of bull sperm after exposure to a magnetic fluid containing DMSA-coated maghemite nanoparticles (MNP-DMSA) in order to determine nanotoxicity. Bull sperm was incubated with MNP-DMSA at final concentrations of 0.06, 0.03 or 0.015 mg Fe/mL. Sperm kinetics, plasma membrane integrity and acrosome reaction were evaluated over a four-hour incubation period...
June 12, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28555450/usefulness-of-parametric-renal-clearance-images-in-the-assessment-of-basic-risk-factors-for-renalnal-clearance-images-in-the-assessment-of-basic-risk-factors-for-renal-scarring-in-children-with-recurrent-urinary-tract-infections
#4
Ewa Pietrzak-Stelasiak, Małgorzata Bieńkiewicz, Wojciech Woźnicki, Krystyna Bubińska, Magdalena Kowalewska-Pietrzak, Anna Płachcińska, Jacek Kuśmierek
BACKGROUND: Clinically confirmed incidents of acute pyelonephritis (APN) following recurrent infections of urinary tract (UTI) form basic risk factors for renal scarring in children. Vesico-uretheral reflux (VUR) of higher grade is additional risk factor for this scarring. Opinions on diagnostic value of summed sequential images of renal uptake phase (SUM) of dynamic renal scintigraphy in detection of renal scars are diverse. However, several publications point to higher diagnostic efficacy of clearance parametric images (PAR) generated from this study...
2017: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/28533635/tc-99m-ethylenedicysteine-and-tc-99m-dimercaptosuccinic-acid-scintigraphy-comparison-of-the-two-for-detection-of-scarring-and-differential-cortical-function
#5
Anitha Dharmalingam, Shwetal U Pawar, Sandesh V Parelkar, Suruchi S Shetye, Mangala K Ghorpade, Gundu H Tilve
CONTEXT: The differential cortical function obtained by Tc-99m EC is comparable to that of Tc-99m DMSA. However, identification of scars on Tc-99m EC images needs to be studied. AIMS: The aim of the study is to evaluate role of Tc-99m EC for detection of scarring and differential cortical function by comparing with Tc-99m DMSA. SETTINGS AND DESIGN: Prospective observational study of recurrent UTI; minimum 6 weeks after acute episode; when urine examination is negative for pus cells...
April 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28509132/transient-fanconi-syndrome-in-two-preterm-infants-with-hydronephrosis-and-urinary-tract-infection
#6
Takahiro Tominaga, Takeshi Sato, Yosuke Ichihashi, Naoko Amano, Yasuaki Kobayashi, Midori Awazu
Type IV renal tubular acidosis is known to occur in obstructive uropathy with urinary tract infection. Fanconi syndrome, however, has not been described in these settings. We report two preterm infants who developed Fanconi syndrome associated with hydronephrosis and urinary tract infection. Patient 1 is a boy with 21 trisomy, bilateral renal hypoplasia and bilateral vesicoureteral reflux delivered at 35 weeks' gestation. At postnatal day 42, he developed Fanconi syndrome after urinary tract infection, which persisted until the surgical correction of vesicoureteral reflux...
May 2017: CEN Case Reports
https://www.readbyqxmd.com/read/28488726/prediction-of-renal-cortical-defect-and-scar-using-neutrophil-to-lymphocyte-ratio-in-children-with-febrile-urinary-tract-infection
#7
Jeong Won Lee, Joon Soo Park, Kyeong Bae Park, Gyeong Hee Yoo, Seung Soo Kim, Sang Mi Lee
AIM: This study is aimed to evaluate the predictive value of the neutrophil-to-lymphocyte ratio (NLR) for cortical defect on initial and follow-up Tc-99m dimercaptosuccinic acid (DMSA) scan in children with the first febrile urinary tract infection (UTI). METHODS: We retrospectively enrolled 179 children with the first febrile UTI who underwent DMSA scan and laboratory tests. In patients with abnormal DMSA scan findings, follow-up DMSA scan was performed at least 6 months after the initial scan...
May 10, 2017: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/28484294/interobserver-variability-in-interpretation-of-planar-and-spect-tc-99m-dmsa-renal-scintigraphy-in-children
#8
Nermina Beslic, Renata Milardovic, Amera Sadija, Lejla Dzananovic, Semra Cavaljuga
OBJECTIVE: This study objective was to evaluate interobserver agreement between individual pairs of three nuclear medicine physicians in interpretation of renal cortical scintigraphy in children with respect to the mode of acquisition (planar vs. SPECT), diagnoses and kidney site (left vs. right). MATERIALS AND METHODS: Thirty children were imaged in planar and SPECT mode per protocol upon the injection of Tc-99m DMSA dose adjusted to their body weight. Patients were classified according to diagnoses into four groups...
March 2017: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28477320/controversies-regarding-management-of-vesico-ureteric-reflux
#9
Ramesh Babu, Sujit Chowdhary
The primary goal in the management of a child with urinary tract infection (UTI) is to prevent recurrence of UTI and acquired renal damage. Approximately 15% of children develop renal scarring after a first episode of febrile UTI. Vesico-ureteric reflux (VUR) is diagnosed in 30-40% of children imaged after first febrile UTI. The 'top-down' approach involving ultrasound and dimercaptosuccinic acid scan (DMSA) first after an appropriate interval following UTI, can help in avoiding voiding cystourethrogram (VCUG), an invasive test with higher radiation exposure...
May 6, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28466457/comparison-of-99mtc-dmsa-renal-scintigraphy-with-biochemical-and-histopathological-findings-in-animal-models-of-acute-kidney-injury
#10
Hossein Fatemikia, Mohammad Seyedabadi, Zynab Karimi, Kiarash Tanha, Majid Assadi, Kaveh Tanha
Biochemical and histological assays are currently used for the diagnosis and characterization of kidney injury. The purpose of this study was to compare technetium-99m-labeled dimercaptosuccinic acid ((99m)Tc-DMSA) renal scintigraphy, as a non-invasive method, with common biochemical and histopathological methods in two animal models of acute kidney injury. Nephrotoxicity was induced either by gentamicin (100 mg/kg/day for one week) or unilateral ureteral ligation (UUO). Renal scintigraphy was performed 1 h after intravenous injection of 99mTc-DMSA (3 mCi)...
May 2, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28458233/raman-and-drift-spectra-vibrational-assignments-and-quantum-mechanical-calculations-of-centrosymmetric-meso-2-3-dimercaptosuccinic-acid
#11
Ibrahim A Shaaban, Abdalla Karoyo, Lee D Wilson, Tarek A Mohamed
The Raman spectrum (3700-100cm(-1)) of meso-2,3-Dimercaptosuccinic acid (meso-DMSA; C4H6O4S2) was recorded in the solid phase using 514.5 and 785nm excitation lines. Whereas, the DRIFT spectrum (4000-400cm(-1)) of the sample powdered in KBr was obtained. Moreover, DFT-B3LYP/6-31G(d) geometry optimization and frequency calculations were carried out for centrosymmetric trans (Ci), gauche (C1; G(+)/G(-)) and eclipsed (Cs; Ef and C1; E(+)/E(-)) rotational isomers in favor of a trans conformation, the least energy with real frequencies...
April 18, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28453880/predicting-postnatal-renal-function-of-prenatally-detected-posterior-urethral-valves-using-fetal-diffusion-weighted-magnetic-resonance-imaging-with-apparent-diffusion-coefficient-determination
#12
Alice Faure, Nicoleta Panait, Michel Panuel, Pierre Alessandrini, Claude D'Ercole, Kathia Chaumoitre, Thierry Merrot
METHODS: Between 2003 and 2014, 11 MRI were performed on fetuses (between 28-32 weeks) in whom second trimester sonography suggested severe bilateral urinary tract anomalies, suspected of PUV. RESULTS: The ADC of the 11 fetuses ranged from 1.3 to 2.86 mm2 s - 1 (median = 1.79 mm2s - 1, normal range for fetal kidney: 1.1-1.8). Two pregnancies with ADC > 2.6 mm2s - 1 were interrupted; the autopsy confirmed PUV and Potter syndrome. For the remaining nine babies, the follow-up was 5...
April 28, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28417852/nuclear-medicine-in-pediatric-nephro-urology-an-overview
#13
REVIEW
Iosif Mendichovszky, Bernardita Troncoso Solar, Naima Smeulders, Marina Easty, Lorenzo Biassoni
In the context of ante-natally diagnosed hydronephrosis, the vast majority of children with a dilated renal pelvis do not need any surgical treatment, as the dilatation resolves spontaneously with time. Slow drainage demonstrated at Tc-99m-mercaptoacetyltriglycine (MAG3) renography does not necessarily mean obstruction. Obstruction is defined as resistance to urinary outflow with urinary stasis at the level of the pelvic-ureteric junction (PUJ) which, if left untreated, will damage the kidney. Unfortunately this definition is retrospective and not clinically helpful...
May 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28377028/transurethral-incision-of-ureterocele-does-the-time-of-presentation-affect-the-need-for-further-surgical-interventions
#14
A Hodhod, R Jednak, J Khriguian, M El-Sherbiny
OBJECTIVES: Ureterocele management is considered to be one of the famous debates in pediatric urology. Despite some considering transurethral ureterocele incision (TUI) as a temporary line of treatment, others have reported good results in terms of being a definitive treatment. The present study evaluated the feasibility of TUI as a definitive line of management. Moreover, it studied the impact of presentation on the outcomes. PATIENTS AND METHODS: The charts of patients who had ureteroceles from 1995 to 2015 were retrospectively reviewed...
March 18, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28373085/choose-your-cell-model-wisely-the-in-vitro-nanoneurotoxicity-of-differentially-coated-iron-oxide-nanoparticles-for-neural-cell-labeling
#15
Freya Joris, Daniel Valdepérez, Beatriz Pelaz, Tianqiang Wang, Shareen H Doak, Bella B Manshian, Stefaan J Soenen, Wolfgang J Parak, Stefaan C De Smedt, Koen Raemdonck
Currently, there is a large interest in the labeling of neural stem cells (NSCs) with iron oxide nanoparticles (IONPs) to allow MRI-guided detection after transplantation in regenerative medicine. For such biomedical applications, excluding nanotoxicity is key. Nanosafety is primarily evaluated in vitro where an immortalized or cancer cell line of murine origin is often applied, which is not necessarily an ideal cell model. Previous work revealed clear neurotoxic effects of PMA-coated IONPs in distinct cell types that could potentially be applied for nanosafety studies regarding neural cell labeling...
April 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28370971/top-down-approach-is-possible-strategy-for-predicting-break-through-futis-and-renal-scars-in-infants
#16
Shina Kawai, Takahiro Kanai, Taiju Hyuga, Shigeru Nakamura, Jun Aoyagi, Takane Ito, Takashi Saito, Jun Odaka, Rieko Furukawa, Toshinori Aihara, Hideo Nakai
BACKGROUND: Several reports have mainly examined whether acute-phase technetium-99m dimercaptosuccinic acid (DMSA) scintigraphy can detect vesicoureteral reflux (VUR) and recommend acute-phase DMSA scintigraphy for initial imaging in children with febrile urinary tract infections (fUTIs). Recently, it has been emphasized the importance of identifying patients who have risks of recurrent fUTIs (r-fUTIs). To clarify the effectiveness of DMSA scintigraphy for predicting r-fUTIs in infants, we investigated the relationship between the defects on DMSA scintigraphy and r- fUTIs...
March 31, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28349748/rash-and-pyrexia-after-succimer-dimercaptosuccinic-acid-dmsa
#17
Anneka Varma, Sally M Bradberry, J Allister Vale
No abstract text is available yet for this article.
March 28, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28319815/shape-dependent-enzyme-like-activity-of-co3o4-nanoparticles-and-their-conjugation-with-his-tagged-egfr-single-domain-antibody
#18
Wei Zhang, Jinlai Dong, Yang Wu, Peng Cao, Lina Song, Ming Ma, Ning Gu, Yu Zhang
In this study, Co3O4 nanopolyhedrons, nanocubes, nanoplates and nanorods were synthesized and characterized. Furthermore, the peroxidase- and catalase-like activities of these Co3O4 nanoparticles (NPs) were studied and influence of the exposed crystal planes was explored. According to their morphology and peroxidase-like activity, dimercaptosuccinic acid (DMSA) modified Co3O4 nanopolyhedrons synthesized via coprecipitation method (Co3O4 NHs) were selected as a proper candidate for the immunohistochemical (IHC) detection of epidermal growth factor receptor (EGFR) expression in non-small cell lung cancer (NSCLC) tissues...
June 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28299237/asymptomatic-urolithiasis-complicated-by-nephrocutaneous-fistula
#19
Marion Hamard, Gaël Amzalag, Christoph D Becker, Pierre-Alexandre Poletti
Asymptomatic spontaneous nephrocutaneous fistula is a rare and severe complication of chronic urolithiasis. We report a case of 56-year-old woman with a nephrocutaneous fistula (NFC) which developed from a superinfected urinoma following calyceal rupture due to an obstructing calculus in the left ureter. The patient was clinically asymptomatic and came to the emergency department for a painless left flank fluctuating mass. This urinoma was superinfected, with a delayed development of renal abscesses and perirenal phlegmon found on contrast-enhanced uro-computed tomography (CT), responsible for left renal vein thrombophlebitis and left psoas abscess...
2017: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/28256495/the-evaluation-of-renal-parenchymal-scarring-using-static-renal-scintigraphy-after-percutaneous-nephrolithotomy-operations
#20
S Yalcinkaya, N Ates, M Yuksel, E Islamoglu, H Tokgoz, E U Ates, A Yildız, S Yilmaz, M Savas
OBJECTIVE: To analyze whether operative techniques and other variables related to patient and renal stone characteristics affect potential renal parenchymal damage. MATERIALS AND METHODS: The study population comprised 64 patients who underwent percutaneous nephrolithotomy operations (PCNL). Data of the operated renal units, renal stone burden, route and number of entries, dilation techniques, duration of surgery, preoperative and postoperative glomerular filtration rate (GFR) and relative dimercaptosuccinic acid (DMSA) uptakes, as well as the changes in hemoglobin values, were recorded and analyzed for all patients...
March 2017: Nigerian Journal of Clinical Practice
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