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https://www.readbyqxmd.com/read/29588142/diffusion-weighted-magnetic-resonance-imaging-is-more-sensitive-than-dimercaptosuccinic-acid-scintigraphy-in-detecting-parenchymal-lesions-in-children-with-acute-pyelonephritis-a-prospective-study
#1
Alice Bosakova, Dana Salounova, Jaroslav Havelka, Otakar Kraft, Pavel Sirucek, Radim Kocvara, Michal Hladik
INTRODUCTION: Static renal scintigraphy is the gold standard for detection of inflammatory changes in the renal parenchyma in acute pyelonephritis. Our aim was to determine whether diffusion-weighted magnetic resonance imaging (DW-MRI) was comparable with static renal scintigraphy (DMSA-SRS) to demonstrate acute renal parenchymal lesions. OBJECTIVE: To compare99m Tc-dimercaptosuccinic acid static renal scintigraphy (DMSA-SRS) with diffusion-weighted magnetic resonance imaging (DW-MRI) for detecting acute inflammatory changes in the renal parenchyma in children with febrile urinary tract infection...
March 13, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29576374/prediction-of-vesicoureteral-reflux-in-children-with-febrile-urinary-tract-infection-using-relative-uptake-and-cortical-defect-in-dmsa-scan
#2
Il Ki Hong, Mi Hae Chung, Joong Hyun Bin, Kyung-Yil Lee, Jung Sue Kim, Chung Ho Kim, Jin-Soon Suh
BACKGROUND: Vesicoureteral reflux (VUR) is an important urologic anomaly that causes renal injury in children with febrile urinary tract infection (UTI). The present study aimed to evaluate the associations of abnormalities detected on technetium-99m-labeled dimercaptosuccinic acid (DMSA) scans, focusing on the association with VUR of the levels of relative decrease in kidney function and cortical defects after a first febrile UTI in children. METHODS: All 171 children underwent ultrasonography, DMSA scan and voiding cystourethrography (VCUG)...
March 6, 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29560586/children-with-abnormal-dmsa-nuclear-scan-present-a-higher-risk-of-recurrent-febrile-urinary-tract-infections
#3
EDITORIAL
Luke Harper, Yan Lefevre, Xavier Delforge, David Bourquard, Cyril Ferdynus
No abstract text is available yet for this article.
March 20, 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29487326/potential-use-of-superparamagnetic-iron-oxide-nanoparticles-for-in-vitro-and-in-vivo-bioimaging-of-human-myoblasts
#4
Kamil R Wierzbinski, Tomasz Szymanski, Natalia Rozwadowska, Jakub D Rybka, Agnieszka Zimna, Tomasz Zalewski, Karolina Nowicka-Bauer, Agnieszka Malcher, Magdalena Nowaczyk, Michal Krupinski, Michal Fiedorowicz, Piotr Bogorodzki, Pawel Grieb, Michal Giersig, Maciej K Kurpisz
Myocardial infarction (MI) is one of the most frequent causes of death in industrialized countries. Stem cells therapy seems to be very promising for regenerative medicine. Skeletal myoblasts transplantation into postinfarction scar has been shown to be effective in the failing heart but shows limitations such, e.g. cell retention and survival. We synthesized and investigated superparamagnetic iron oxide nanoparticles (SPIONs) as an agent for direct cell labeling, which can be used for stem cells imaging. High quality, monodisperse and biocompatible DMSA-coated SPIONs were obtained with thermal decomposition and subsequent ligand exchange reaction...
February 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29473304/non-enhanced-magnetic-resonance-imaging-versus-renal-scintigraphy-in-acute-pyelonephritis
#5
Jun Aoyagi, Takahiro Kanai, Jun Odaka, Takane Ito, Takashi Saito, Hiroyuki Betsui, Rieko Furukawa, Waka Nakata, Takanori Yamagata
The utility of non-enhanced magnetic resonance imaging (MRI) has not been examined extensively for diagnosing acute pyelonephritis (APN) in children. The aims of this study were to compare non-enhanced MRI with technetium-99 m dimercaptosuccinic acid (99m Tc-DMSA) renal scintigraphy in detecting APN. Six boys and one girl with temperature ≥38°C and positive urine culture received both non-enhanced MRI with whole body diffusion-weighted imaging (DWI) and99m Tc-DMSA scintigraphy ≤7 days from the fever onset...
February 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29472098/comparison-of-relative-renal-functions-calculated-with-99m-tc-dtpa-and-99m-tc-dmsa-for-kidney-patients-of-wide-age-ranges
#6
M A Momin, M N A Abdullah, M S Reza
Renal scintigraphy is an imaging method that uses small amount of radioactive materials called radiotracers, a Gamma camera and a computer to evaluate kidney functions and its anatomy. The present work reports the comparison of the relative renal functions (RRF) calculated with technetium-99m dimercaptosuccinic acid (99m Tc‑DMSA) and technetium-99m diethylenetriaminepentaacetic acid (99m Tc‑DTPA) for kidney patients of ages between 5 months and 71 years. A total of 50 patients including 29 male and 21 female has been selected and studied for renography...
January 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29462089/evaluation-of-the-management-of-severe-trauma-kidney-injury-and-long-term-renal-function-in-children
#7
Camille Overs, Youssef Teklali, Bernard Boillot, Delphine Poncet, Pierre-Yves Rabattu, Yohan Robert, Christian Piolat
BACKGROUND: To evaluate the management and long term renal function with DMSA scintigraphy in pediatric severe traumatic kidney injury (STKI) grade IV (STKI IV) and V (STKI V) at the trauma center of Grenoble Teaching Hospital. METHODS: This is a single-center observational retrospective study between 2004 and 2014. All children under the age of 15 managed at the Grenoble teaching Hospital for a STKI IV or V were included. The trauma grade was radiologically diagnosed on arrival at hospital, using the classification of the American Association for Surgery of Trauma...
February 17, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29446671/unenhanced-mri-as-an-alternative-to-99m-tc-labeled-dimercaptosuccinic-acid-scintigraphy-in-the-detection-of-pediatric-renal-scarring
#8
Colbey W Freeman, Talissa A Altes, Patrice K Rehm, Eduard E de Lange, Luke Lancaster, John P Mugler, James T Patrie, Sean Corbett, Carlos Leiva-Salinas, Lucia Flors
OBJECTIVE: The purpose of this study was to determine whether unenhanced MRI without sedation is a feasible substitute for dimercaptosuccinic acid (DMSA) scintigraphy in the detection of renal scars in pediatric patients. SUBJECTS AND METHODS: Patients scheduled for 99mTc-labeled DMSA scintigraphy for assessment of possible renal scars were recruited to undergo unenhanced MRI (free-breathing fat-suppressed T2-weighted single-shot turbo spin-echo and T1-weighted gradient-echo imaging, 13 minutes' total imaging time)...
February 15, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29412212/porous-gold-nanocluster-decorated-manganese-monoxide-nanocomposites-for-microenvironment-activatable-mr-photoacoustic-ct-tumor-imaging
#9
Yu Liu, Xiaolin Lv, Heng Liu, Zijian Zhou, Jianpan Huang, Shenglan Lei, Shuhui Cai, Zhong Chen, Yanli Guo, Zhiwei Chen, Xi Zhou, Liming Nie
Stimuli-responsive nanoprobes that integrate multi-modal imaging capacities are highly desirable for precise tumor visualization. Herein, novel porous gold nanocluster-decorated manganese monoxide nanocomposites (MnO@Au NCs) were synthesized via a facile approach. The porous gold nanocluster layer was germinated on the surface of the as-prepared MnO@DMSA NPs through simple reduction of chloroauric acid in the presence of hydroxylamine hydrochloride. The MnO@Au NCs could be effectively internalized by tumor cells and slowly release Mn2+ ions within the acidic tumor microenvironment, improving the visualization of the tumor morphology...
February 7, 2018: Nanoscale
https://www.readbyqxmd.com/read/29384833/a-review-of-paediatric-administered-radiopharmaceutical-activities-to-determine-compliance-with-prescription-guidelines
#10
Giovanni Bibbo, Victoria Sigalas, Ian Kirkwood
OBJECTIVE: Attempts are underway to standardize paediatric administered activities, but equally important is knowing the actual activities administered to patients. In this work, paediatric administered activities are reviewed to determine compliance with the institution-prescribed guidelines. PATIENTS AND METHODS: Paediatric administered activities for common studies at our institution, August 2011 to January 2017, have been analysed to determine their deviations from the set guideline tolerance of 10% from prescribed activities...
March 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29359888/management-of-paediatric-high-grade-blunt-renal-trauma-a-10-year-single-centre-uk-experience
#11
Kee Yong Wong, Ram Jeeneea, Andrew Healey, Laurence Abernethy, Harriet Corbett, Fiona McAndrew, Paul Losty
INTRODUCTION: To report the management and outcome of paediatric patients sustaining high grade blunt renal trauma. PATIENTS AND METHODS: Medical records were examined for all Grade III to Grade V blunt renal trauma cases admitted to a paediatric trauma centre during the era(s) 2005 to 2015. Data collected and analysed included - demographics, imaging modalities, management, length of hospital stay, complications and follow-up outcome(s). RESULTS: 18 children (12 males, 6 females) with mean age 11 years (4 - 15) were included...
January 23, 2018: BJU International
https://www.readbyqxmd.com/read/29341603/pokmt1-from-the-polyketomycin-biosynthetic-machinery-of-streptomyces-diastatochromogenes-t%C3%A3-6028-belongs-to-the-emerging-family-of-c-methyltransferases-that-act-on-coa-activated-aromatic-substrates
#12
Xun Guo, Ivana Crnovcic, Chin-Yuan Chang, Jun Luo, Jeremy R Lohman, Monica Papinski, Andreas Bechthold, Geoffrey P Horsman, Ben Shen
Recent biochemical characterizations of the MdpB2 CoA ligase and MdpB1 C-methyltransferase (C-MT) from the maduropeptin (MDP, 2) biosynthetic machinery revealed unusual pathway logic involving C-methylation occurring on a CoA-activated aromatic substrate. Here we confirmed this pathway logic for the biosynthesis of polyketomycin (POK, 3). Biochemical characterization unambiguously established that PokM3 and PokMT1 catalyze the sequential conversion of 6-methylsalicylic acid (6-MSA, 4) to form 3,6-dimethylsalicylyl-CoA (3,6-DMSA-CoA, 6), which serves as the direct precursor for the 3,6-dimethylsalicylic acid (3,6-DMSA) moiety in the biosynthesis of 3...
January 17, 2018: Biochemistry
https://www.readbyqxmd.com/read/29324920/technetium-99m-dimercaptosuccinic-acid-renal-scintigraphy-can-guide-clinical-management-in-congenital-hydronephrosis
#13
Biljana Bazić-Đorović, Marija Radulović, Marija Šišić, Ljiljana Jauković, Sanja Dugonjić, Dragan Pucar, Zoran Janković, Slobodanka Beatović, Milica Janković, Zoran Krstić, Boris Ajdinović
OBJECTIVE: The purpose of this study was to evaluate damage of the kidney with technetium-99m-dimercaptosuccinic acid (99m Tc-DMSA) scintigraphy in children with congenital hydronephrosis (CH) and the influence of other postnatal associated diagnoses on abnormal 99m Tc-DMSA findings. SUBJECTS AND METHODS: 99m Tc-DMSA scintigraphy in 54 children (17 girls and 37 boys), aged from 2 months to 5 years (median 11 months) with 66 congenital hydronephrotic renal units (RU) (42 unilateral hydronephrosis-29 boys and 13 girls; 12 bilateral hydronephrosis-8 boys and 4 girls) was performed...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29283363/dual-functional-nayf-4-yb-3-er-3-nayf-4-yb-3-nd-3-core-shell-nanoparticles-for-cell-temperature-sensing-and-imaging
#14
Zengliang Shi, Yue Duan, Xingjun Zhu, Qiwei Wang, DongDong Li, Ke Hu, Wei Feng, Fuyou Li, Chunxiang Xu
Lanthanide-doped up-conversion nanoparticles (UCNPs) provide a remote temperature sensing approach to monitoring biological microenvironments. In this research, the UCNPs of NaYF4 :Yb3+ , Er3+ @NaYF4 :Yb3+ , Nd3+ with hexagonal (β)-phase were synthesized and applied in cell temperature sensing as well as imaging after surface modification with meso-2, 3-dimercaptosuccinic acid. In the core-shell UCNPs, Yb3+ ions were introduced as energy transfer media between sensitizers of Nd3+ and activators of Er3+ to improve Er3+ emission and prevent their quenching behavior due to multiple energy levels of Nd3+ ...
March 2, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29233628/xanthogranulomatous-pyelonephritis-in-a-paediatric-cohort-1963-2016-outcomes-from-a-large-single-center-series
#15
I Stoica, F O'Kelly, M B McDermott, F M J Quinn
BACKGROUND: Xanthogranulomatous pyelonephritis (XGP) is an uncommon chronic destructive granulomatous inflammation of the kidney. It was first described in 1916, and is thought to affect 6/1000 cases of pyelonephritis. Its manifestations are varied, and with a limited number of cases in the literature, the optimal diagnosis and management of XGP in the paediatric cohort is still unknown. MATERIAL AND METHODS: The medical records of children who were diagnosed and treated for XGP at the current unit during the period 1963-2016, inclusive, were retrospectively reviewed...
November 24, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29223716/alkaline-degradation-of-lyophilized-dmsa-prior-to-labeling-with-99m-tc-identification-and-development-of-the-degradation-pathway-by-hplc-and-ms
#16
Erika V Almeida, Samuel L De Brito
INTRODUCTION: Complexes of technetium-99m (99mTc) with meso-dimercaptosuccinic acid (DMSA) have been widely used as diagnostic agents in nuclear medicine. The degradation products (DP) of DMSA formed under different forced conditions have been identified through HPLC-DAD and LC-MSn studies. In this study, the DMSA kit was subjected to forced degradation under hydrolysis conditions as prescribed by the International Conference on Harmonization (ICH) guideline Q1A. METHODS: Chromatographic separation was accomplished on a reverse phase Shim-Pack VP-ODS (150 mm × 4...
February 2018: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29218427/the-role-of-nonautologous-and-autologous-adipose-derived-mesenchymal-stem-cell-in-acute-pyelonephritis
#17
Shabnam Sabetkish, Nastaran Sabetkish, Mahba Ataei Talebi, Shahnaz Halimi, Abdol-Mohammad Kajbafzadeh
We compared the therapeutic effects of autologous and nonautologous adipose-derived mesenchymal stem cell (ADMSC), in ameliorating the renal function in a rabbit model of acute pyelonephritis. The difference of perirenal and neck subcutaneous ADMSCs were also evaluated. Twenty female rabbits were apportioned to 5 groups. In group I (n = 4), the rabbits were injected direct inoculation of Escherichia coli (E. coli) into the right kidney. In group II (n = 4), autologous ADMSCs obtained from nape adipose tissue were injected into the subcapsular space 1 week after E...
December 7, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/29211403/the-role-of-fetal-maternal-microchimerism-as-a-natural-born-healer-in-integrity-improvement-of-maternal-damaged-kidney
#18
Abdol-Mohammad Kajbafzadeh, Shabnam Sabetkish, Nastaran Sabetkish
PURPOSE: To identify the fetal stem cell (FSC) response to maternal renal injury with emphasis on renal integrity improvement and Y chromosome detection in damaged maternal kidney. MATERIALS AND METHODS: Eight non-green fluorescent protein (GFP) transgenic Sprague- Dawley rats were mated with GFP-positive transgenic male rats. Renal damage was induced on the right kidney at gestational day 11. The same procedure was performed in eight non-pregnant rats as control group...
December 7, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29204797/prevention-of-renal-scarring-in-acute-pyelonephritis-by-probiotic-therapy-an-experimental-study
#19
Nastaran Sabetkish, Shabnam Sabetkish, Mohammad Javad Mohseni, Abdol-Mohammad Kajbafzadeh
We evaluated the protective effects of probiotic administration as a prophylaxis treatment and immediately after fever onset in increasing the immune response and decreasing the renal scarring in a rat model of acute pyelonephritis. Twenty-four rats were apportioned to three groups. In GI (n = 8), the rats were injected with direct inoculation of Escherichia coli into the right kidney. In GII (n = 8), the rats received a probiotic regimen 1 month before E. coli injection and the probiotic regimen was continued for the next 2 months...
December 4, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29187904/multimodality-imaging-of-angiogenesis-in-a-rabbit-atherosclerotic-model-by-gebp11-peptide-targeted-nanoparticles
#20
Tao Su, Ya-Bin Wang, Dong Han, Jing Wang, Shun Qi, Lei Gao, Ya-Hui Shao, Hong-Yu Qiao, Jiang-Wei Chen, Shu-Hui Liang, Yong-Zhan Nie, Jia-Yi Li, Feng Cao
Background and Aims: Angiogenesis is an important pathological process during progression of plaque formation, which can result in plaque hemorrhage and vulnerability. This study aims to explore non-invasive imaging of angiogenesis in atherosclerotic plaque through magnetic resonance imaging (MRI) and positron emission tomography (PET) by using GEBP11 peptide targeted magnetic iron oxide nanoparticles in a rabbit model of atherosclerosis. Methods: The dual-modality imaging probe was constructed by coupling 2, 3-dimercaptosuccinnic acid-coated paramagnetic nanoparticles (DMSA-MNPs) and the PET68 Ga chelator 1,4,7-triazacyclononane-N, N', N''-triacetic acid (NOTA) to GEBP11 peptide...
2017: Theranostics
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