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Maria Eugenia Fortes Brollo, Patricia Hernández Flores, Lucía Gutiérrez, Christer Johansson, Domingo Francisco Barber, María Del Puerto Morales
The aggregation processes of magnetic nanoparticles in biosystems are analysed by comparing the magnetic properties of three systems with different spatial distributions of the nanoparticles. The first one is iron oxide nanoparticles (NPs) of 14 nm synthesized by coprecipitation with two coatings, (3-aminopropyl)trimethoxysilane (APS) and dimercaptosuccinic acid (DMSA). The second one is liposomes with encapsulated nanoparticles, which have different configurations depending on the NP coating (NPs attached to the liposome surface or encapsulated in its aqueous volume)...
June 20, 2018: Physical Chemistry Chemical Physics: PCCP
Kirushanthi Sakthithasan, Pierre Lévy, Joël Poupon, Robert Garnier
BACKGROUND: We evaluated the efficacy of two antidotes, edetate calcium disodium (CaNa2 EDTA) and dimercaptosuccinic acid (DMSA), for the treatment of lead poisoning in adults. METHODS: Thirty-seven patients with blood lead concentrations >40 μg/dL and positive CaNa2 EDTA lead mobilization were randomized to receive 1050 mg/m2 /day of oral DMSA (n = 21) or 500 mg/m2 /day of intravenous CaNa2 EDTA (n = 16) over two five-day courses separated by a 10-day rest period...
June 11, 2018: Clinical Toxicology
Sara Fuentes, Andrés Gómez-Fraile, Isabel Carrillo-Arroyo, Daniel Cabezalí-Barbancho, Cristina Tordable-Ojeda
OBJECTIVES: In recent years, different studies have mentioned the recurrence of vesicoureteral reflux (VUR) endoscopically resolved, an exceptional event after open surgery. The aim of this study is to describe the evolution of the cases of recurrence identified in our center to assess the importance of this event. METHOD: We have identified the cases of VUR that recurred after successful endoscopic treatment in our anesdepartment. We have analyzed diagnostic tests, management and final outcome...
June 2018: Archivos Españoles de Urología
Çağla Serpil Doğan, Nevin Semerci Koyun, Gülşah Kaya Aksoy, Bülent Çekiç, Murat Savaş, Elif Çomak
OBJECTIVE: In this study, we aimed to assess renal outcomes of delayed diagnosis of dilating primary vesicoureteral reflux (VUR) following recurrent febrile urinary tract infections (fUTIs) and its diagnostic imaging procedures. MATERIAL AND METHODS: The medical records of patients who underwent ultrasonography (US), non- acute dimercaptosuccinic acid (Tc-99mDMSA) scintigraphy and voiding cystourethrography (VCUG), and who were older than 2 years at the time of VUR diagnosis were retrospectively reviewed...
May 31, 2018: Turkish Journal of Urology
Eda Tokat, Serhat Gurocak, Iyimser Ure, Cenk Acar, Zafer Sınık, Mustafa Ozgur Tan
BACKGROUND/PURPOSE: The "European Association of Urology (EAU) Guidelines on Vesicoureteral Reflux (VUR) in Children (September 2012)" established risk classification by analyzing and defining risk factors for each patient. In this study we aimed to investigate how our initial treatment procedures were affected by EAU/ESPU guideline vesicoureteral reflux risk grouping and to compare the early clinical results of treatments performed before and after the risk classification in our patients with VUR...
June 2, 2018: Journal of Pediatric Surgery
Bo Ae Yun, Eun Mi Yang, Chan Jong Kim
BACKGROUND: Urinary tract infection (UTI) is the most common bacterial infection in infants. Renal parenchymal involvement is an important prognostic factor; however, early detection of parenchymal involvement in UTI may be difficult during infancy. This study aimed to assess whether a recently established biomarker of UTI, neutrophil gelatinase-associated lipocalin (NGAL), can serve as a useful marker for the detection of cortical defects (CD) and to determine the appropriate diagnostic cut-off value of NGAL in infants with febrile UTI...
September 2018: Annals of Laboratory Medicine
Yasar Kandur, Ahmet Salan, Ahmet Gokhan Guler, Fatih Tuten
PURPOSE: Ureteropelvic junction obstruction (UPJO) is one of the most common causes of hydronephrosis other than transient hydronephrosis. In children with unilateral hydronephrosis, mercaptoacetyltriglycine-3 diuretic renography (MAG3 ) is used to calculate differential renal function and to assess drainage. The aim of our study is to examine whether anteroposterior pelvic diameter on renal ultrasound (US) scan can predict both differential renal function (DFR) and obstruction in pediatric patients, and whether an US adequately identifies those patients who need further investigation...
May 24, 2018: International Urology and Nephrology
Guobin Mao, Chen Liu, Mingyuan Du, Yuwei Zhang, Xinghu Ji, Zhike He
Galactose oxidase is a copper-activated enzyme and have a vital role in metabolism of galactose. Much of the work is focused on determining the amount of galactose in the blood rather than measuring the amount of galactose oxidase to urge the galactosemia patients to restrict milk intake. Here, a simple and effective method was developed for Cu2+ and copper-activated enzyme detection based on homogenous alloyed CdZnTeS quantum dots (QDs). Meso- 2,3-dimercaptosuccinic acid (DMSA) was used as the reducing agent for preparing QDs and the highest quantum yield of CdZnTeS QDs was 69...
August 1, 2018: Talanta
Danka Pokrajac, Lejla Kapur-Pojskic, Sandra Vegar-Zubovic, Renata Milardovic
Background: The pathogenesis of renal scarring (RS) after first febrile urinary tract infection (UTI) in children is multifactorial. In addition to well-known risk factors, a role for genetic predisposition has been suggested. Aims: To determine whether deoxyribonucleic acid (DNA) polymorphisms at the plasminogen activator inhibitor -1 (PAI-1) gene were associated with evolution to RS following a febrile UTI in infants. Materials and Methods: Our research included 100 infants, 84 girls and 16 boys, ages up to 1 year with a first febrile UTI, increased inflammatory parameters and positive urine culture treated at the Pediatric Clinic II of the University Clinical Center Sarajevo (UCCS)...
April 2018: Medical Archives
Natalia Alvarez, Reyes Delgado Alvira, Yurema Gonzalez Ruiz, Rafael Fernandez Atuan, Alexander Siles Hinojosa, Miguel Angel Rihuete Heras, Marisa Justa Roldan, Jesus Gracia Romero
Introduction: Vesicoureteral reflux (VUR) is one of the most common ailments in children. Evidence-based guidelines recommend conservative treatment in children with VUR, followed by endoscopic surgery in those with breakthrough febrile urinary tract infections (UTIs). Despite this fact, the management of VUR is still controversial. Our objective is to evaluate the conservative strategy in children with primary VUR in terms of renal function and scarring, and identify factors associated with poor prognosis in those children...
2018: Central European Journal of Urology
Yordanka Gluhcheva, Kalina Kamenova, Petar Dorkov, Yulia Lobanova, Margarita Skalnaya, Juliana Ivanova
Cadmium (Cd) is an environmental pollutant shown to induce multi organ dysfunction. In this study we present novel data about the effects of meso-2,3-dimercaptosuccinic acid (DMSA), monensin and salinomycin on the concentration of Cd in skeletal muscles of mice exposed to Cd (II) acetate treatment for 14 days. The impact of Cd and the chelating agents on the endogenous concentrations of calcium (Ca), copper (Cu), iron (Fe), magnesium (Mg), phosphorous (P), selenium (Se) and zinc (Zn) was also investigated. Subacute exposure of mice to Cd (II) acetate resulted in a significant accumulation of the toxic metal ion in the skeletal muscles compared to the untreated controls...
April 20, 2018: Journal of Trace Elements in Medicine and Biology
Alice Bosakova, Dana Salounova, Jaroslav Havelka, Otakar Kraft, Pavel Sirucek, Radim Kocvara, Michal Hladik
INTRODUCTION: Static renal scintigraphy is the gold standard for detection of inflammatory changes in the renal parenchyma in acute pyelonephritis. Our aim was to determine whether diffusion-weighted magnetic resonance imaging (DW-MRI) was comparable with static renal scintigraphy (DMSA-SRS) to demonstrate acute renal parenchymal lesions. OBJECTIVE: To compare 99m Tc-dimercaptosuccinic acid static renal scintigraphy (DMSA-SRS) with diffusion-weighted magnetic resonance imaging (DW-MRI) for detecting acute inflammatory changes in the renal parenchyma in children with febrile urinary tract infection...
March 13, 2018: Journal of Pediatric Urology
Il Ki Hong, Mi Hae Chung, Joong Hyun Bin, Kyung-Yil Lee, Jung Sue Kim, Chung Ho Kim, Jin-Soon Suh
BACKGROUND: Vesicoureteral reflux (VUR) is an important urologic anomaly that causes renal injury in children with febrile urinary tract infection (UTI). The present study aimed to evaluate the associations of abnormalities detected on technetium-99m-labeled dimercaptosuccinic acid (DMSA) scans, focusing on the association with VUR of the levels of relative decrease in kidney function and cortical defects after a first febrile UTI in children. METHODS: All 171 children underwent ultrasonography, DMSA scan and voiding cystourethrography (VCUG)...
March 6, 2018: Pediatrics and Neonatology
Luke Harper, Yan Lefevre, Xavier Delforge, David Bourquard, Cyril Ferdynus
No abstract text is available yet for this article.
March 20, 2018: World Journal of Pediatrics: WJP
Kamil R Wierzbinski, Tomasz Szymanski, Natalia Rozwadowska, Jakub D Rybka, Agnieszka Zimna, Tomasz Zalewski, Karolina Nowicka-Bauer, Agnieszka Malcher, Magdalena Nowaczyk, Michal Krupinski, Michal Fiedorowicz, Piotr Bogorodzki, Pawel Grieb, Michal Giersig, Maciej K Kurpisz
Myocardial infarction (MI) is one of the most frequent causes of death in industrialized countries. Stem cells therapy seems to be very promising for regenerative medicine. Skeletal myoblasts transplantation into postinfarction scar has been shown to be effective in the failing heart but shows limitations such, e.g. cell retention and survival. We synthesized and investigated superparamagnetic iron oxide nanoparticles (SPIONs) as an agent for direct cell labeling, which can be used for stem cells imaging. High quality, monodisperse and biocompatible DMSA-coated SPIONs were obtained with thermal decomposition and subsequent ligand exchange reaction...
February 27, 2018: Scientific Reports
Jun Aoyagi, Takahiro Kanai, Jun Odaka, Takane Ito, Takashi Saito, Hiroyuki Betsui, Rieko Furukawa, Waka Nakata, Takanori Yamagata
The utility of non-enhanced magnetic resonance imaging (MRI) has not been examined extensively for diagnosing acute pyelonephritis (APN) in children. The aims of this study were to compare non-enhanced MRI with technetium-99 m dimercaptosuccinic acid (99m Tc-DMSA) renal scintigraphy in detecting APN. Six boys and one girl with temperature ≥38°C and positive urine culture received both non-enhanced MRI with whole body diffusion-weighted imaging (DWI) and 99m Tc-DMSA scintigraphy ≤7 days from the fever onset...
February 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
M A Momin, M N A Abdullah, M S Reza
Renal scintigraphy is an imaging method that uses small amount of radioactive materials called radiotracers, a Gamma camera and a computer to evaluate kidney functions and its anatomy. The present work reports the comparison of the relative renal functions (RRF) calculated with technetium-99m dimercaptosuccinic acid (99m Tc‑DMSA) and technetium-99m diethylenetriaminepentaacetic acid (99m Tc‑DTPA) for kidney patients of ages between 5 months and 71 years. A total of 50 patients including 29 male and 21 female has been selected and studied for renography...
January 2018: Physica Medica: PM
Camille Overs, Youssef Teklali, Bernard Boillot, Delphine Poncet, Pierre-Yves Rabattu, Yohan Robert, Christian Piolat
BACKGROUND: To evaluate the management and long term renal function with DMSA scintigraphy in pediatric severe traumatic kidney injury (STKI) grade IV (STKI IV) and V (STKI V) at the trauma center of Grenoble Teaching Hospital. METHODS: This is a single-center observational retrospective study between 2004 and 2014. All children under the age of 15 managed at the Grenoble teaching Hospital for a STKI IV or V were included. The trauma grade was radiologically diagnosed on arrival at hospital, using the classification of the American Association for Surgery of Trauma...
February 17, 2018: Journal of Trauma and Acute Care Surgery
Colbey W Freeman, Talissa A Altes, Patrice K Rehm, Eduard E de Lange, Luke Lancaster, John P Mugler, James T Patrie, Sean Corbett, Carlos Leiva-Salinas, Lucia Flors
OBJECTIVE: The purpose of this study was to determine whether unenhanced MRI without sedation is a feasible substitute for dimercaptosuccinic acid (DMSA) scintigraphy in the detection of renal scars in pediatric patients. SUBJECTS AND METHODS: Patients scheduled for 99m Tc-labeled DMSA scintigraphy for assessment of possible renal scars were recruited to undergo unenhanced MRI (free-breathing fat-suppressed T2-weighted single-shot turbo spin-echo and T1-weighted gradient-echo imaging, 13 minutes' total imaging time)...
April 2018: AJR. American Journal of Roentgenology
Yu Liu, Xiaolin Lv, Heng Liu, Zijian Zhou, Jianpan Huang, Shenglan Lei, Shuhui Cai, Zhong Chen, Yanli Guo, Zhiwei Chen, Xi Zhou, Liming Nie
Stimuli-responsive nanoprobes that integrate multi-modal imaging capacities are highly desirable for precise tumor visualization. Herein, novel porous gold nanocluster-decorated manganese monoxide nanocomposites (MnO@Au NCs) were synthesized via a facile approach. The porous gold nanocluster layer was germinated on the surface of the as-prepared MnO@DMSA NPs through simple reduction of chloroauric acid in the presence of hydroxylamine hydrochloride. The MnO@Au NCs could be effectively internalized by tumor cells and slowly release Mn2+ ions within the acidic tumor microenvironment, improving the visualization of the tumor morphology...
February 22, 2018: Nanoscale
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