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Whole brain irradiation

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https://www.readbyqxmd.com/read/28299642/cerebromicrovascular-dysfunction-predicts-cognitive-decline-and-gait-abnormalities-in-a-mouse-model-of-whole-brain-irradiation-induced-accelerated-brain-senescence
#1
Zoltan Ungvari, Stefano Tarantini, Peter Hertelendy, M Noa Valcarcel-Ares, Gabor A Fülöp, Sreemathi Logan, Tamas Kiss, Eszter Farkas, Anna Csiszar, Andriy Yabluchanskiy
Whole brain irradiation (WBI) is a mainstream therapy for patients with both identifiable brain metastases and prophylaxis for microscopic malignancies. However, it also promotes accelerated senescence in healthy tissues and leads to progressive cognitive dysfunction in up to 50% of tumor patients surviving long term after treatment, due to γ-irradiation-induced cerebromicrovascular injury. Moment-to-moment adjustment of cerebral blood flow (CBF) via neuronal activity-dependent cerebromicrovascular dilation (functional hyperemia) has a critical role in maintenance of healthy cognitive function...
February 2017: Geroscience
https://www.readbyqxmd.com/read/28297350/impact-of-small-mu-segment-and-dose-rate-on-delivery-accuracy-of-volumetric-modulated-arc-therapy-vmat
#2
Long Huang, Tingliang Zhuang, Anthony Mastroianni, Toufik Djemil, Taoran Cui, Ping Xia
Volumetric-modulated arc therapy (VMAT) plans may require more control points (or segments) than some of fixed-beam IMRT plans that are created with a limited number of segments. Increasing number of control points in a VMAT plan for a given prescription dose could create a large portion of the total number of segments with small number monitor units (MUs) per segment. The purpose of this study is to investigate the impact of the small number MU/segment on the delivery accuracy of VMAT delivered with various dose rates...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28283192/supine-craniospinal-irradiation-in-pediatric-patients-by-proton-pencil-beam-scanning
#3
Paolo Farace, Nicola Bizzocchi, Roberto Righetto, Francesco Fellin, Francesco Fracchiolla, Stefano Lorentini, Lamberto Widesott, Carlo Algranati, Barbara Rombi, Sabina Vennarini, Maurizio Amichetti, Marco Schwarz
BACKGROUND AND PURPOSE: Proton therapy is the emerging treatment modality for craniospinal irradiation (CSI) in pediatric patients. Herein, special methods adopted for CSI at proton Therapy Center of Trento by pencil beam scanning (PBS) are comprehensively described. MATERIALS AND METHODS: Twelve pediatric patients were treated by proton PBS using two/three isocenters. Special methods refer to: (i) patient positioning in supine position on immobilization devices crossed by the beams; (ii) planning field-junctions via the ancillary-beam technique; (iii) achieving lens-sparing by three-beams whole-brain-irradiation; (iv) applying a movable-snout and beam-splitting technique to reduce the lateral penumbra...
March 7, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28223673/-a-case-of-meningeal-carcinomatosis-and-small-cell-lung-carcinoma-effectively-treated-using-a-multidisciplinary-approach
#4
Kota Hikima, Mikie Nagayama, Takashi Sato, Takashi Inoue, Mutsumi Nagai
A 65-year-old man visited our hospital with dyspnea and cough. He was diagnosed with small cell lung carcinoma (cT4N2M1b, Stage IV). The disease partially responded to systemic chemotherapy. However, it was progressive and metastasized to the brain 3 months after 6 courses of chemotherapy. Therefore, whole brain irradiation was performed. Subsequently, weakness of the lower extremities and vesicorectal disturbances appeared. Meningeal carcinomatosis was diagnosed by enhanced magnetic resonance imaging and liquid examination...
February 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28182655/regional-analysis-of-volumes-and-reproducibilities-of-automatic-and-manual-hippocampal-segmentations
#5
Fabian Bartel, Hugo Vrenken, Fetsje Bijma, Frederik Barkhof, Marcel van Herk, Jan C de Munck
PURPOSE: Precise and reproducible hippocampus outlining is important to quantify hippocampal atrophy caused by neurodegenerative diseases and to spare the hippocampus in whole brain radiation therapy when performing prophylactic cranial irradiation or treating brain metastases. This study aimed to quantify systematic differences between methods by comparing regional volume and outline reproducibility of manual, FSL-FIRST and FreeSurfer hippocampus segmentations. MATERIALS AND METHODS: This study used a dataset from ADNI (Alzheimer's Disease Neuroimaging Initiative), including 20 healthy controls, 40 patients with mild cognitive impairment (MCI), and 20 patients with Alzheimer's disease (AD)...
2017: PloS One
https://www.readbyqxmd.com/read/28156673/palliative-whole-brain-radiotherapy-predictors-of-prescribing-5-versus-10-fractions
#6
Sarah Baker, Kim Paulson, Brock J Debenham, Sunita Ghosh, David L Ma, Fleur Huang, Karen P Chu, Diane Severin, John Amanie, Tirath Nijjar, Samir Patel, Ericka Wiebe, Brita Lavender Danielson, Bronwen LeGuerrier, Alysa M Fairchild
219 Background: The optimal dose for palliative whole brain radiotherapy (WBRT) continues to be debated. Common regimens include 20 Gy in five and 30 Gy in 10 fractions. We aimed to identify factors associated with WBRT dose schedules, hypothesizing that clinical prediction of survival (CPS) would influence prescribing practice. METHODS: Demographic and clinicopathologic data were collected for consecutive patients with brain metastases receiving WBRT through a dedicated palliative radiation oncology clinic...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28133024/-surgical-resection-of-solitary-brain-metastasis-from-breast-cancer
#7
Kei Kimizuka, Hiroshi Miyake, Junko Sugiyama, Michitaka Ogura, Nozomi Kamisada, Moritaka Ohhara, Woodae Kang, Reona Katoh, Hironobu Satoh, Noriaki Yokose, Shoshi Satoh, Masamichi Fukushima
BACKGROUND: Brain metastasis from breast cancer has a poor prognosis. For solitary cerebral metastases, surgical resection may contribute to the improvement of survival and QOL. We studied the prognosis and characteristics of solitary brain metastasis from breast cancer in patients undergoing surgical resection. METHODS: Seventeen patients had tumors metastatic to the brain at Kasukabe Municipal Hospital between June 2009 and May 2016, and 7 of them underwent craniotomy...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28126476/optimization-of-brain-metastases-radiotherapy-with-tomohda
#8
Slav Yartsev, Glenn Bauman
An upgrade of the helical tomotherapy technology by introducing variable fan-field width (dynamic jaws) reduced the penumbra in superior-inferior direction for the target. Possible implementation of this upgrade even for the cases of the targets with different dose prescriptions is proposed. An example of brain metastasis in proximity to the optical apparatus in need of the whole brain irradiation of 30 Gy and higher dose to the lesion is considered.
April 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28109544/cost-effectiveness-of-prophylactic-cranial-irradiation-with-hippocampal-avoidance-in-limited-stage-small-cell-lung-cancer
#9
Xuanlu M Qu, Mark V Mishra, Glenn S Bauman, Ben Slotman, Minesh Mehta, Vinai Gondi, Alexander V Louie
BACKGROUND AND PURPOSE: Prophylactic cranial irradiation (PCI) in limited stage small cell lung cancer (LS-SCLC) prevents brain metastases and improves survival, with the potential for neurocognitive toxicity. RTOG0933 demonstrated that hippocampal avoidance (HA) during whole brain radiotherapy preserves neurocognition. This study's objective was to evaluate the cost-effectiveness of HA-PCI in LS-SCLC through decision analysis. MATERIALS AND METHODS: A Markov model was developed to simulate the clinical course of LS-SCLC who received HA-PCI or conventional PCI (C-PCI)...
January 18, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28100859/-cotton-dam-wash-cytology-a-technique-for-diagnosis-and-prevention-of-dissemination-during-resection-of-metastatic-brain-tumors
#10
Koichi Mitsuya, Yoko Nakasu, Sachiyo Ono, Nakamasa Hayashi, Reiko Watanabe, Ichiro Ito
The management of brain metastases has been important in neurosurgical oncology. Resection of a brain metastasis carries an increased risk of leptomeningeal dissemination than other treatment modalities such as irradiation or pharmacotherapy. We have utilized intraoperative wash cytology of cotton patties covering the brain surface. The cytology information contributes to making a decision of postoperative whole brain radiation. We named the method as "cotton dam", that serves as a check and catch of neoplastic cells on the brain surface during resection surgery...
January 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28081463/analysis-of-the-results-of-recurrent-intracranial-meningiomas-treated-with-re-radiosurgery
#11
Moinay Kim, Do Hee Lee, Hyun Jung Kim Rn, Young Hyun Cho, Jeong Hoon Kim, Do Hoon Kwon
OBJECTS: Meningioma is the most common intracranial neoplasm, comprising approximately 30% of all primary intracranial tumors (Claus et al., 2005) [1]. Treatment options include observation, microsurgical resection, stereotactic radiosurgery (SRS), and whole brain radiation therapy (WBRT). Gamma knife radiosurgery (GKRS) is a very effective treatment for intracranial meningiomas; previous studies showed the tumor control rate at 5-10 years of follow-up as 84.3%-100% in all cases (Feigl et al...
February 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28075181/accelerated-or-conventional-whole-brain-irradiation-of-malignant-melanoma
#12
Ragnar Hultborn, Johanna Sand, Sara Kinhult, Lotta Lundgren, Ulrika Stierner, Ingela Turesson, Per Albertsson
No abstract text is available yet for this article.
January 11, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28064217/clinical-factors-asssociated-with-treatment-outcomes-following-whole-brain-irradiation-in-patients-with-prostate-cancer
#13
REVIEW
Liesa Dziggel, Steven E Schild, Theo Veninga, Amira Bajrovic, Dirk Rades
BACKGROUND/AIM: Patients with prostate cancer represent a small minority of cancer patients presenting with metastases to the brain. This study investigated the role of whole-brain irradiation (WBI) in this rare group. PATIENTS AND METHODS: Eighteen such patients were included. Clinical factors including fractionation program of WBI, age at WBI, Karnofsky performance score (KPS), number of metastases to the brain, involvement of extracerebral metastatic sites, time from prostate cancer diagnosis to WBI and recursive-partitioning-analysis (RPA) class were investigated regarding local (intracerebral) control and survival...
January 2, 2017: In Vivo
https://www.readbyqxmd.com/read/28061768/a-matched-pair-study-comparing-whole-brain-irradiation-alone-to-radiosurgery-or-fractionated-stereotactic-radiotherapy-alone-in-patients-irradiated-for-up-to-three-brain-metastases
#14
Dirk Rades, Stefan Janssen, Liesa Dziggel, Oliver Blanck, Amira Bajrovic, Theo Veninga, Steven E Schild
BACKGROUND: This matched-pair study was initiated to validate the results of a retrospective study of 186 patients published in 2007 that compared whole-brain irradiation (WBI) alone and radiosurgery (RS) alone for up to three brain metastases. METHODS: One-hundred-fifty-two patients receiving WBI alone for up to three brain metastases were matched with 152 patients treated with RS of fractionated stereotactic radiotherapy (FSRT) alone 1:1 for each of eight factors (age, gender, Eastern Oncology Cooperative Group (ECOG)-performance score, nature of tumor, brain metastases number, extra-cerebral spread, period from cancer detection to irradiation of brain metastases, and recursive partitioning analysis (RPA)-class...
January 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28048850/su-g-brc-14-multi-lesion-multi-rx-brain-radiosurgery-with-novel-single-isocenter-technique
#15
N Honig, S Alani, A Schlocker, N Shtraus, A Kanner
PURPOSE: There is a strong trend to treat multiple brain metastases with radiosurgery rather than whole brain irradiation. This feasibility study investigates a novel planning technique for radio-surgical treatment of multiple brain lesions with differing dose prescriptions, a single isocenter, and dynamic conformal arcs. The novel technique will be compared to the well-established single-isocenter volumetric modulated arc therapy (VMAT) technique commonly used for treating brain lesions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048574/su-f-t-349-dosimetric-comparison-of-three-different-simultaneous-integrated-boost-irradiation-techniques-for-multiple-brain-metastases-intensity-modulatedradiotherapy-hybrid-intensity-modulated-radiotherapy-and-volumetric-modulated-arc-therapy
#16
X Lin, T Sun, Y Yin
PURPOSE: To study the dosimetric impact of intensity-modulated radiotherapy (IMRT), hybrid intensity-modulated radiotherapy (h-IMRT) and volumetric modulated arc therapy(VMAT) for whole-brain radiotherapy (WBRT) with simultaneous integrated boost in patients with multiple brain metastases. METHODS: Ten patients with multiple brain metastases were included in this analysis. The prescribed dose was 45 Gy to the whole brain (PTVWBRT) and 55 Gy to individual brain metastases (PTVboost) delivered simultaneously in 25 fractions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047069/su-f-t-446-improving-craniospinal-irradiation-technique-using-volumetric-modulated-arc-therapy-vmat-planning-and-its-dosimetric-verification
#17
X Yang, M Tejani, X Jiang, E Elder, A Dhabaan
PURPOSE: The purpose of this study is to investigate a volumetric modulated arc therapy (VMAT) treatment planning technique for supine craniospinal irradiation (CSI). Evaluate the suitability of VMAT for CSI with dosimetric measurements and compare it to 3D conformal planning using specific plan metrics such as dose conformity, homogeneity, and dose of organs at risk (OAR). METHODS: Ten CSI patients treated with conventional 3D technique were re-planned with VMAT...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046705/su-f-t-202-an-evaluation-method-of-lifetime-attributable-risk-for-comparing-between-proton-beam-therapy-and-intensity-modulated-x-ray-therapy-for-pediatric-cancer-patients-by-averaging-four-dose-response-models-for-carcinoma-induction
#18
M Tamura, Y Ito, H Sakurai, M Mizumoto, S Kamizawa, S Murayama, H Yamashita, S Takao, R Suzuki, H Shirato
PURPOSE: To examine how much lifetime attributable risk (LAR) as an in silico surrogate marker of radiation-induced secondary cancer would be lowered by using proton beam therapy (PBT) in place of intensity modulated x-ray therapy (IMXT) in pediatric patients. METHODS: From 242 pediatric patients with cancers who were treated with PBT, 26 patients were selected by random sampling after stratification into four categories: a) brain, head, and neck, b) thoracic, c) abdominal, and d) whole craniospinal (WCNS) irradiation...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046453/su-g-tep3-09-proton-minibeam-radiation-therapy-increases-normal-tissue-resistance
#19
Y Prezado, W Gonzalez-Infantes, S Heinrich, D Labiod, M Juchaux, I Martinez-Rovira, C Nauraye, A Patriarca, C Peucelle, C Sebrie
PURPOSE: The dose tolerances of normal tissues continue being the main limitation in radiotherapy. To overcome it, we recently proposed a novel concept: proton minibeam radiation therapy (pMBRT) [1]. It allies the physical advantages of protons with the normal tissue preservation observed when irradiated with submillimetric spatially fractionated beams (minibeam radiation therapy) [2]. The dose distributions are such that the tumor receives a homogeneous dose distribution, while normal tissues benefit from the spatial fractionation of the dose...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28011499/development-of-a-survival-score-for-patients-with-cerebral-metastases-from-melanoma
#20
Lena Sehmisch, Steven E Schild, Dirk Rades
BACKGROUND/AIM: To develop a survival score for patients receiving whole-brain irradiation (WBI) alone for cerebral metastases from melanoma. PATIENTS AND METHODS: Forty-five patients who met the required criteria were included. WBI doses had to be >30 Gy. Six variables were analyzed: age, gender, Karnofsky performance score (KPS), number of cerebral metastases, extracranial metastatic spread and interval from diagnosis of melanoma until WBI. In order to estimate patients' survival scores, variables showing at least a trend (p<0...
2017: Anticancer Research
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