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Whole brain irradiation

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https://www.readbyqxmd.com/read/29599370/predictive-factors-for-local-control-and-survival-in-patients-with-cancer-of-unknown-primary-cup-irradiated-for-cerebral-metastases
#1
Dirk Rades, Liesa Dziggel, Stefan Janssen, Mai Trong Khoa, Vuong Ngoc Duong, Vu Huu Khiem, Niklas Gebauer, Tobias Bartscht, Steven E Schild
BACKGROUND/AIM: To identify predictors of local control and survival after whole-brain irradiation (WBI) for cerebral metastases from cancer of unknown primary (CUP). PATIENTS AND METHODS: In 140 patients receiving WBI alone or following resection, seven factors were investigated including treatment approach, WBI-regimen, age, gender, Eastern Cooperative Oncology Group (ECOG) performance score, number of cerebral lesions and extra-cerebral metastases. RESULTS: On univariate analysis, resection plus WBI and boost (p=0...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29557535/the-breast-graded-prognostic-assessment-is-associated-with-the-survival-outcomes-in-breast-cancer-patients-receiving-whole-brain-re-irradiation
#2
Shih-Fan Lai, Yu-Hsuan Chen, Tony Hsiang-Kuang Liang, Che-Yu Hsu, Huang-Chun Lien, Yen-Sen Lu, Chiun-Sheng Huang, Sung-Hsin Kuo
INTRODUCTION: Whole brain (WB) re-irradiation for breast cancer patients with progressive brain metastasis after first-course WB radiotherapy (WBRT) is controversial. In this study, we sought to investigate the association between the molecular sub-classifications and breast-specific Graded Prognostic Assessment (GPA, which includes the Karnofsky performance status, molecular subtypes, and age as its indices) and the outcomes of breast cancer patients who received WB re-irradiation. METHODS: Twenty-three breast cancer patients who received WB re-irradiation for relapsed and progressive intracranial lesions after first-course WBRT between 2004 and 2016 were retrospectively reviewed...
March 20, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29554321/robotic-radiosurgery-for-brain-metastases-diagnosed-with-either-space-or-mprage-sequence-cyber-space-a-single-center-prospective-randomized-trial
#3
Rami A El Shafie, Angela Paul, Denise Bernhardt, Kristin Lang, Thomas Welzel, Tanja Sprave, Adriane Hommertgen, Johannes Krisam, Daniela Schmitt, Sebastian Klüter, Kai Schubert, Christina Klose, Meinhard Kieser, Jürgen Debus, Stefan Rieken
BACKGROUND: Stereotactic radiosurgery (SRS) of brain metastases (BM) is recommended in oligometastatic scenarios as a less toxic treatment alternative to whole-brain radiotherapy. Recent findings support SRS for patients with multiple (>3) BM. Furthermore, advances in MR imaging have facilitated the detection of very small BM, as advances in SRS technology have facilitated the highly conformal and simultaneous treatment of multiple target lesions. OBJECTIVE: To compare efficacy and toxicity of repeated frameless robotic SRS of up to 10 simultaneous BM through a single-center prospective randomized trial...
March 15, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29551465/the-possible-role-of-maintenance-treatment-for-primary-central-nervous-system-lymphoma
#4
REVIEW
Osnat Bairey, Tali Siegal
Primary central nervous system lymphoma (PCNSL) is a rare and aggressive brain tumor. The prognosis is poor, with high rates of relapse and disease progression after treatment. In addition, PCNSL affects a largely older population, so that a significant proportion of patients are ineligible for intensive therapies and high-dose chemotherapy. The elderly patients are also susceptible to the accelerated and detrimental cognitive side effects of whole-brain irradiation which is an alternative consolidation to high-dose chemotherapy...
March 11, 2018: Blood Reviews
https://www.readbyqxmd.com/read/29507854/primary-intramedullary-malignant-lymphoma-in-the-cervical-cord-with-a-presyrinx-state
#5
Kohei Chida, Atsushi Sugawara, Takahiro Koji, Takaaki Beppu, Yoshiharu Mue, Tamotsu Sugai, Knuaki Ogasawara
A 79-year-old man presented with primary intramedullary malignant lymphoma with a presyrinx state in the cervical cord manifesting as left hemiparesis and hemidysesthesia. The magnetic resonance imaging (MRI) scan showed an intramedullary mass in the cervical spinal cord at the level of C1 and T2-weighted image prolongation from the medulla to the level of C5. According to the progression of hemiparesis, he underwent an emergency removal of the tumor under general anesthesia. The tumor was totally removed, and the peritumoral signal abnormality was not present in the postoperative MRI...
December 30, 2017: Curēus
https://www.readbyqxmd.com/read/29493009/cranial-irradiation-increases-tumor-growth-in-experimental-breast-cancer-brain-metastasis
#6
Amanda M Hamilton, Suzanne M Wong, Eugene Wong, Paula J Foster
Whole-brain radiotherapy is the standard of care for patients with breast cancer with multiple brain metastases and, although this treatment has been essential in the management of existing brain tumors, there are many known negative consequences associated with the irradiation of normal brain tissue. In our study, we used in vivo magnetic resonance imaging analysis to investigate the influence of radiotherapy-induced damage of healthy brain on the arrest and growth of metastatic breast cancer cells in a mouse model of breast cancer brain metastasis...
March 1, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29485078/hippocampal-sparing-during-craniospinal-irradiation-what-did-we-learn-about-the-incidence-of-perihippocampus-metastases
#7
Laetitia Padovani, Frédérique Chapon, Nicolas André, Mohamed Boucekine, Anne Geoffray, Franck Bourdeau, Julien Masliah-Planchon, Line Claude, Aymeri Huchet, Anne Laprie, Stephane Supiot, Bernard Coche-Dequéant, Christine Kerr, Claire Alapetite, Julie Leseur, Tandat Nguyen, Sophie Chapet, Valerie Bernier, Pierre-Yves Bondiau, Georges Noel, Jean Louis Habrand, Stephanie Bolle, François Doz, Christelle Dufour, Xavier Muracciole, Christian Carrie
PURPOSE: To identify the incidence of patients with perihippocampal metastases to assess the risk of brain relapse when sparing the hippocampal area. Medulloblastoma (MB) represents 20% of pediatric brain tumors. For high-risk MB patients, the 3- to 5-year event-free survival rate has recently improved from 50% to >76%. Many survivors, however, experience neurocognitive side effects. Several retrospective studies of patients receiving whole brain irradiation (WBI) have suggested a relationship between the radiation dose to the hippocampus and neurocognitive decline...
March 15, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29477038/post-irradiation-protective-effects-of-ectoine-on-brain-and-testicles-in-male-mice
#8
Rowaida Refaat, Dalia Sarhan, Metwali Kotb, Eman El-Abd, Emad El-Bassiouni
BACKGROUND: The present study aimed to investigate the possible post-irradiation protective effects of ectoine on CNS and testes of male mice. METHODS: The study included thirty male Swiss albino mice (20-22 gm). Mice were divided into five groups (six each); controls (injected intraperitoneally with 0.2 ml saline), irradiated group1 (received six Gy whole body x-irradiation single dose, injected with saline, and sacrificed after one day), irradiated group 2 (x-irradiated, injected with saline, and sacrificed after one week), ectoine group 1 (x-irradiated, injected with 200 mg/kg ectoine, and sacrificed after one day), and ectoine group 2 (x-irradiated, injected daily with 200 mg/kg ectoine, and sacrificed after one week)...
October 4, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29440180/resistance-promoting-effects-of-ependymoma-treatment-revealed-through-genomic-analysis-of-multiple-recurrences-in-a-single-patient
#9
Christopher A Miller, Sonika Dahiya, Tiandao Li, Robert Fulton, Matthew D Smyth, Gavin P Dunn, Joshua B Rubin, Elaine R Mardis
BACKGROUND: As in other brain tumors, multiple recurrences after complete resection and irradiation of supratentorial ependymoma are common and frequently result in patient death. This standard-of-care treatment was established in the pre-genomic era without the ability to evaluate the effect that mutagenic therapies may exert on tumor evolution and in promoting resistance, recurrence, and death. We seized a rare opportunity to characterize treatment effects and the evolution of a single patient's ependymoma across four recurrences after different therapies...
February 13, 2018: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/29435016/cranial-irradiation-inhibits-hippocampal-neurogenesis-via-dnmt1-and-dnmt3a
#10
Shengjun Ji, Xin Ding, Jiang Ji, Haohao Wu, Rui Sun, Xiaoyang Li, Liyuan Zhang, Ye Tian
Impairment of neurogenesis in the hippocampus following whole-brain irradiation is the most important mechanism of radiation-induced cognitive dysfunction. However, the underlying mechanism remains obscure, meaning an ideal therapeutic target has not been identified. Evidence indicates that DNA methylation in neurons regulates synaptic plasticity and neuronal network activity. In the present study, the expression of DNA methyltransferases (DNMTs) in the hippocampus was analyzed to investigate their potential function in radiation-induced neurogenesis impairment...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29427386/diffusion-mri-monitoring-of-specific-structures-in-the-irradiated-rat-brain
#11
Julie Constanzo, Matthieu Dumont, Réjean Lebel, Luc Tremblay, Kevin Whittingstall, Laurence Masson-Côté, Sameh Geha, Philippe Sarret, Martin Lepage, Benoit Paquette, Maxime Descoteaux
PURPOSE: The analysis of biological and mesoscopic structures properties by diffusion MRI (dMRI) in brain after radiation therapy remains challenging. In our study, we described the consequences associated with an unwanted dose to healthy tissue, assessing radiation-induced brain alterations of living rats with dMRI compared to histopathology and behavioral assays. METHODS: The right primary motor cortex M1 of the rat brain was targeted by stereotactic radiosurgery with a mean radiation dose of 41 Gy...
February 9, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29413284/brainstem-injury-in-pediatric-patients-with-posterior-fossa-tumors-treated-with-proton-beam-therapy-and-associated-dosimetric-factors
#12
Michelle S Gentile, Beow Y Yeap, Harald Paganetti, Claire P Goebel, Dillon E Gaudet, Sara L Gallotto, Elizabeth A Weyman, Michael L Morgan, Shannon M MacDonald, Drosoula Giantsoudi, Judith Adams, Nancy J Tarbell, Hanne Kooy, Torunn I Yock
PURPOSE: Proton radiation therapy is commonly used in young children with brain tumors for its potential to reduce late effects. However, some proton series report higher rates of brainstem injury (0%-16%) than most photon series (2.2%-8.6%). We report the incidence of brainstem injury and a risk factor analysis in pediatric patients with posterior fossa primary tumors treated with proton radiation therapy at our institution. METHODS AND MATERIALS: The study included 216 consecutive patients treated between 2000 and 2015...
March 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29404305/profile-of-patients-undergoing-palliative-radiotherapy-a-single-institute-study-from-a-tertiary-care-oncology-center
#13
Virender Suhag, B S Sunita, Pankaj Vats, Nilotpal Chakravarty, Mayuri Jain, Rekha S Vashisht
Background: Palliative radiotherapy (PRT) plays a significant role in the palliation of symptoms in patients with cancer and constitutes nearly 50% of the workload in different settings. Aims: The aim is to study patient-, disease-, and treatment-related characteristics in locoregionally advanced and metastatic malignancies meriting palliative management. Setting and Design: This was a retrospective observational study in a tertiary care government institute with academic and research potential...
October 2017: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/29378267/safety-of-combined-pd-1-pathway-inhibition-and-intracranial-radiation-therapy-in-non-small-cell-lung-cancer
#14
Harper G Hubbeling, Emily F Schapira, Nora K Horick, Kelly E H Goodwin, Jessica J Lin, Kevin S Oh, Alice T Shaw, William A Mehan, Helen A Shih, Justin F Gainor
INTRODUCTION: Intracranial metastases are a common cause of morbidity and mortality in patients with advanced NSCLC, and are frequently managed with radiation therapy (RT). The safety of cranial RT in the setting of treatment with immune checkpoint inhibitors (ICIs) has not been established. METHODS: We identified patients with advanced NSCLC with brain metastases who received cranial RT and were treated with or without programmed cell death 1/programmed death ligand 1 inhibitors between August 2013 and September 2016...
January 31, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29370245/metamaterial-based-transmit-and-receive-system-for-whole-body-magnetic-resonance-imaging-at-ultra-high-magnetic-fields
#15
Tim Herrmann, Thorsten Liebig, Johannes Mallow, Christian Bruns, Jörg Stadler, Judith Mylius, Michael Brosch, Jan Taro Svedja, Zhichao Chen, Andreas Rennings, Henning Scheich, Markus Plaumann, Marcus J B Hauser, Johannes Bernarding, Daniel Erni
Magnetic resonance imaging (MRI) at ultra-high fields (UHF), such as 7 T, provides an enhanced signal-to-noise ratio and has led to unprecedented high-resolution anatomic images and brain activation maps. Although a variety of radio frequency (RF) coil architectures have been developed for imaging at UHF conditions, they usually are specialized for small volumes of interests (VoI). So far, whole-body coil resonators are not available for commercial UHF human whole-body MRI systems. The goal of the present study was the development and validation of a transmit and receive system for large VoIs that operates at a 7 T human whole-body MRI system...
2018: PloS One
https://www.readbyqxmd.com/read/29366417/protective-effects-of-magnesium-sulfate-on-radiation-induced-brain-injury-in-rats
#16
Na Chen, Run-Jun Xu, Li-Li Wang, Meng Zhang, Shi-Cheng Feng, Ju-Ying Zhou, Yu Tu
The effect of magnesium sulfate on brain tissue of SD rats irradiated by 6MeV electron was investigated. SD rats were divided into three groups: control group, irradiation (IR group) and irradiation treated with magnesium sulfate (IR+M group). After being anesthetized, the whole brains of IR group and IR+M group were exposed to 6 MeV electron radiation. IR+M group was i.p. injected with 10% magnesium sulfate (400 mg/kg) one day before radiation and three day, five days after radiation. And on the 1st, 3rd, 7th and 14th day after radiation, SD rats were euthanatized to take brain tissue for the detection of calcium, redox status and cell apoptosis, as well as the expression of NF-κB and ICAM-1...
January 23, 2018: Current Drug Delivery
https://www.readbyqxmd.com/read/29361626/-secondary-dementia-due-to-leptomeningeal-metastasis-of-breast-cancer-improved-by-whole-brain-radiation
#17
Mariko Asai, Hiroshi Tanaka, Yasutomo Goto, Tetsuya Yamada, Norihiro Yuasa, Eiji Takeuchi, Hideo Miyake, Hidemasa Nagai, Yuichiro Yoshioka, Masataka Okuno, Natsuko Kawai, Takayuki Minami, Takuya Nagao, Shingo Maeda, Koichi Mouri, Kouji Fukata, Hironori Mizuno, Takuji Iwase, Kanji Miyata
A 62-year-old woman received chemotherapy for breast cancer with bone metastasis and malignant pleural and pericardial effusion. She was examined by imaging for progressive cognitive impairment and headache. Enhanced MRI findings showed multiple solid tumors on brain surface, and brain perfusion scintigraphy showed blood flow decrease in both parietal lobes. She was diagnosed with secondary dementia due to leptomeningeal metastases of breast cancer, and whole brain external irradiation was performed(30 Gy/15 Fr)...
December 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29359989/a-role-for-endothelial-cells-in-radiation-induced-inflammation
#18
Martina Boström, Marie Kalm, Yohanna Eriksson, Cecilia Bull, Anders Ståhlberg, Thomas Björk-Eriksson, Nina Hellström Erkenstam, Klas Blomgren
PURPOSE: To unravel the role of the vasculature in radiation-induced brain tissue damage. MATERIALS AND METHODS: Postnatal day 14 mice received a single dose of 10 Gy cranial irradiation and were sacrificed 6 hours, 24 hours or 7 days post-irradiation. Endothelial cells were isolated from the hippocampus and cerebellum using fluorescence-activated cell sorting, followed by cell cycle analysis and gene expression profiling. RESULTS: Flow cytometric analysis revealed that irradiation increased the percentage of endothelial cells, relative to the whole cell population in both the hippocampus and the cerebellum...
January 23, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29344836/boost-irradiation-integrated-to-whole-brain-radiotherapy-in-the-management-of-brain-metastases
#19
Ágnes Dobi, Emese Fodor, Anikó Maráz, Zsófia Együd, Adrienne Cserháti, László Tiszlavicz, Zita Reisz, Pál Barzó, Zoltán Varga, Katalin Hideghéty
Our retrospective analysis aimed to evaluate the clinical value of dose intensification schemes: WBRT and consecutive, delayed, or simultaneous integrated boost (SIB) in brain metastasis (BM) management. Clinical data and overall survival (OS) of 468 patients with BM from various primaries treated with 10 × 3 Gy WBRT (n = 195), WBRT+ 10 × 2 Gy boost (n = 125), or simultaneously 15 × 2.2 Gy WBRT+0.7 Gy boost (n = 148) during a 6-year period were statistically analysed. Significant difference in OS could be detected with additional boost to WBRT (3...
January 17, 2018: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29333126/impact-on-radiation-dose-and-volume-v57-gy-of-the-brain-on-recurrence-and-survival-of-patients-with-glioblastoma-multiformae
#20
Igor Stojkovski, Valentina Krstevska, Snezhana Smichkoska
Background: The aim of the study was to analyze impact of irradiated brain volume V57 Gy (volume receiving 57 Gy and more) on time to progression and survival of patients with glioblastoma. Patients and methods: Dosimetric analysis of treatment plan data has been performed on 70 patients with glioblastoma, treated with postoperative radiochemotherapy with temozolomide, followed by adjuvant temozolomide. Patients were treated with 2 different methods of definition of treatment volumes and prescription of radiation dose...
December 2017: Radiology and Oncology
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