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https://www.readbyqxmd.com/read/29332158/combined-sublethal-irradiation-and-agonist-anti-cd40-enhance-donor-t-cell-accumulation-and-control-of-autochthonous-murine-pancreatic-tumors
#1
Lindsay K Ward-Kavanagh, Kathleen M Kokolus, Timothy K Cooper, Aron E Lukacher, Todd D Schell
Tumor-reactive T lymphocytes can promote the regression of established tumors. However, their efficacy is often limited by immunosuppressive mechanisms that block T cell accumulation or function. ACT provides the opportunity to ameliorate immune suppression prior to transfer of tumor-reactive T cells to improve the therapeutic benefit. We evaluated the combination of lymphodepleting whole body irradiation (WBI) and agonist anti-CD40 (αCD40) antibody on control of established autochthonous murine neuroendocrine pancreatic tumors following the transfer of naïve tumor-specific CD8 T cells...
January 13, 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29299946/a-new-approach-for-modeling-patient-overall-radiosensitivity-and-predicting-multiple-toxicity-endpoints-for-breast-cancer-patients
#2
Chamberlain Mbah, Kim De Ruyck, Silke De Schrijver, Charlotte De Sutter, Kimberly Schiettecatte, Chris Monten, Leen Paelinck, Wilfried De Neve, Hubert Thierens, Catharine West, Gustavo Amorim, Olivier Thas, Liv Veldeman
INTRODUCTION: Evaluation of patient characteristics inducing toxicity in breast radiotherapy, using simultaneous modeling of multiple endpoints. METHODS AND MATERIALS: In 269 early-stage breast cancer patients treated with whole-breast irradiation (WBI) after breast-conserving surgery, toxicity was scored, based on five dichotomized endpoints. Five logistic regression models were fitted, one for each endpoint and the effect sizes of all variables were estimated using maximum likelihood (MLE)...
January 4, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29282078/short-course-hypofractionated-whole-breast-irradiation-after-conservative-surgery-a-single-institution-phase-ii-study
#3
Paola Pinnarò, Carolina Giordano, Alessia Farneti, Adriana Faiella, Giuseppe Iaccarino, Valeria Landoni, Diana Giannarelli, Patrizia Vici, Lidia Strigari, Giuseppe Sanguineti
BACKGROUND: To assess the oncologic outcomes of hypofractionated whole breast irradiation (Hypo-WBI). METHODS: Eligible patients had undergone breast conservative surgery for early breast cancer (pTis-2) and none/limited nodal involvement. Hypo-WBI consisted of 34 Gy in 10 daily fractions over 2 weeks to the whole breast three-dimensional conformal radiotherapy (3DCRT), followed by a single fraction of 8 Gy to the tumor bed after 1 week (electrons). Primary endpoint is freedom from ipsilateral breast tumor recurrence (IBTR)...
December 27, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29251449/determining-the-optimal-cut-off-scores-for-the-workplace-bullying-inventory
#4
Marie Hutchinson, Joanne Bradbury, Graeme Browne, John Hurley
BACKGROUND: Over the past two decades, there has been considerable research into workplace bullying. One area that remains poorly developed is a tool with the capacity to accurately differentiate between exposed and unexposed employees. AIM: To determine optimal cut-off scores for the Workplace Bullying Inventory (WBI) that accurately classify cases of exposure to workplace bullying. DISCUSSION: Secondary analysis of data collected from Australian public sector employees ( n =2,197) was conducted...
December 18, 2017: Nurse Researcher
https://www.readbyqxmd.com/read/29204163/efficacy-of-single-stage-breast-conserving-treatment-using-multicatheter-partial-breast-brachytherapy-evaluated-by-gec-estro-phase-3-trial
#5
Kazuhiko Sato, Hiromi Fuchikami, Masahiro Kato, Takahiro Shimo, Jun Kubota, Naoko Takeda, Yuko Inoue, Hiroshi Seto, Tomohiko Okawa
Purpose: The GEC-ESTRO has reported the equivalent outcomes of partial breast irradiation (PBI) using multicatheter interstitial brachytherapy (MCB) to whole breast irradiation (WBI) in breast-conserving therapy (BCT). We performed single-stage BCT with partial breast brachytherapy by intraoperative catheter placement. After the categorization of patients into inclusion and exclusion criteria on this trial, our databases were evaluated in order to translate it to Japanese patients. Material and methods: Patients undergoing BCT were retrospectively examined between November 2007 and December 2015...
October 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29132560/alternatives-to-standard-fractionation-radiation-therapy-after-lumpectomy-hypofractionated-whole-breast-irradiation-and-accelerated-partial-breast-irradiation
#6
REVIEW
Nisha Ohri, Bruce G Haffty
Adjuvant whole-breast irradiation (WBI) after lumpectomy has been an established standard of care for decades. Standard-fractionation WBI delivered over 5 to 7 weeks can achieve durable tumor control with low toxicity but can be inconvenient for patients and cost ineffective. Hypofractionated WBI can be completed in 3 to 4 weeks and, based on long-term randomized data, is the preferred standard of care in select patients. Accelerated partial-breast irradiation can be delivered using even shorter treatment regimens...
January 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29114595/use-of-regional-nodal-irradiation-and-its-association-with-survival-for-women-with-high-risk-early-stage-breast-cancer-a-national-cancer-database-analysis
#7
Amy C Moreno, Yan Heather Lin, Isabelle Bedrosian, Yu Shen, Michael C Stauder, Benjamin D Smith, Thomas A Buchholz, Gildy V Babiera, Wendy A Woodward, Simona F Shaitelman
Purpose: The role of regional nodal irradiation (RNI) for patients with breast cancer remains controversial, particularly on the basis of nodal involvement. Using the National Cancer Database, we aimed to validate published data on whether expanding treatment fields from whole-breast irradiation (WBI) to encompass the regional nodes (WBI+RNI) affected overall survival (OS) for patients with node-positive (pN1-3) or high-risk node-negative (pN0) breast cancer treated with breast-conserving surgery and adjuvant chemotherapy...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29082666/internalizing-weight-stigma-prevalence-and-sociodemographic-considerations-in-us-adults
#8
Rebecca M Puhl, Mary S Himmelstein, Diane M Quinn
OBJECTIVE: This study aimed to conduct a comprehensive assessment of the presence, severity, and sociodemographic correlates of weight bias internalization (WBI) across three distinct samples of US adults. METHODS: Levels of WBI were compared in (1) a sample of adults with obesity and heightened risk of weight stigma (N = 456), (2) an online community sample (N = 519), and (3) a national online panel (N = 2,529). Samples 2 and 3 comprised adults with and without obesity...
October 30, 2017: Obesity
https://www.readbyqxmd.com/read/29059428/cost-effectiveness-analysis-comparing-conventional-hypofractionated-and-intraoperative-radiotherapy-for-early-stage-breast-cancer
#9
COMPARATIVE STUDY
Ashish A Deshmukh, Shervin M Shirvani, Lincy Lal, J Michael Swint, Scott B Cantor, Benjamin D Smith, Anna Likhacheva
Background: Early-stage breast cancer is among the most prevalent and costly malignancies treated in the American health care system. Adjuvant radiotherapy after lumpectomy represents a substantial portion of breast cancer expenditures. The relative value of novel radiotherapeutic approaches such as intraoperative radiotherapy (IORT) and hypofractionated whole breast irradiation (HF-WBI) compared with conventionally fractionated whole breast irradiation (CF-WBI) is unknown. Therefore, we used prospectively collected outcomes from randomized clinical trials (RCTs) to compare the cost-effectiveness of these approaches...
November 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28992110/nfat3-c4-mediated-excitotoxicity-in-hippocampal-apoptosis-during-radiation-induced-brain-injury
#10
Meiling Xu, Qiuhong Fan, Junjun Zhang, Yanfang Chen, Ruizhe Xu, Liesong Chen, Peifeng Zhao, Ye Tian
Whole brain irradiation (WBI) has become an indispensible tool in the treatment of head and neck cancer, and it has greatly improved patient survival rate and total survival time. In addition, prophylactic cranial irradiation (PCI) has dramatically decreased the incidence of brain metastatic carcinoma. However, WBI may induce temporary functional deficits or even progressive, irreversible cognitive dysfunction that compromises the quality of life for survivors. Unfortunately, the exact molecular mechanisms for cognitive damage remain elusive, and no treatment or preventative measures are available for use in the clinic...
August 10, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28972265/efficacy-of-a-web-based-intervention-for-concerned-spouses-of-service-members-and-veterans-with-alcohol-misuse
#11
Karen Chan Osilla, Thomas E Trail, Eric R Pedersen, Kristie L Gore, Anagha Tolpadi, Lindsey M Rodriguez
Concerned partners (CPs) of service members and veterans who misuse alcohol face help-seeking barriers and mental health problems. We used multiple regression to evaluate the efficacy of Partners Connect, a four-session web-based intervention (WBI) to address military CPs' mental health and communication. We randomized 312 CPs to the WBI or a control group. Five months later, WBI CPs reported significant reductions in their anxiety and increases in their social support compared to control CPs. Intervention dose was also associated with improved WBI CP outcomes...
October 3, 2017: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/28938661/efficacy-and-safety-of-accelerated-partial-breast-irradiation-a-meta-analysis-of-published-randomized-studies
#12
Gengchun Liu, Zhongyi Dong, Baqun Huang, Yuelong Liu, Yan Tang, Qing Li, Yihui Zhu
BACKGROUND AND PURPOSE: Accelerated partial breast irradiation (APBI) technology has theoretical advantages in comparison with traditional adjuvant radiation therapy (whole-breast irradiation; WBI) after breast-conserving surgery. However, published randomized controlled trials have shown inconsistent outcomes. Therefore, a comprehensive assessment of the effectiveness and safety of APBI technology is needed. RESULTS: A total of 7 studies of 7452 patients were included in this analysis...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28937316/age-dependent-responses-of-brain-myelin-integrity-and-behavioral-performance-to-radiation-in-mice
#13
Zhimeng Fu, Yunfei Zhao, Kaixiang Zhang, Jian Wang, Min Zhang, Xianghui Zhao
Radiation therapy is widely used to treat primary and metastatic brain tumors, but it may also lead to delayed neurological complications. Oligodendrocytes in the central nervous system produce myelin, and myelin integrity becomes highly vulnerable after brain irradiation. In this study, mice at different developmental stages were used to test the age-dependent sensitivity of myelin formation and maintenance, as well as behavioral performance after whole-brain irradiation (WBI). Mice at postnatal days 21 and 28 and at 2 months received a single dose of 25 Gy WBI...
November 2017: Radiation Research
https://www.readbyqxmd.com/read/28935854/comparison-of-helical-tomotherapy-and-direct-tomotherapy-in-bilateral-whole-breast-irradiation-in-a-case-of-bilateral-synchronous-grade-1-and-stage-1-breast-cancer
#14
Valentina Lancellotta, Martina Iacco, Elisabetta Perrucci, Claudio Zucchetti, Anna Concetta Dipilato, Lorenzo Falcinelli, Isabella Palumbo, Cynthia Aristei
BACKGROUND Synchronous bilateral breast cancer is rare. A case is presented where whole breast irradiation (WBI) was planned after breast conserving surgery in a patient with synchronous bilateral breast cancer. A comparison was made between the feasibility of helical tomotherapy and direct tomotherapy. CASE REPORT A 60-year-old woman was found to have bilateral breast nodules on routine mammographic screening, resulting in bilateral lumpectomy and sentinel lymph node biopsy. Histopathology showed a 6 mm diameter invasive ductal carcinoma in the right breast (Grade 1, hormone receptor positive, HER2 negative) and an 8mm diameter tubular carcinoma in the left breast (Grade 1, hormone receptor positive, HER2 negative)...
September 22, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28894694/evaluation-of-partial-breast-reirradiation-with-intraoperative-radiotherapy-after-prior-thoracic-radiation-a-single-institution-report-of-outcomes-and-toxicity
#15
Christine Chin, Priya Jadeja, Bret Taback, David P Horowitz, Sheldon M Feldman, Richard Ha, Eileen P Connolly
INTRODUCTION: Mastectomy is the current standard of care for ipsilateral breast tumor recurrences after prior whole breast irradiation (WBI). We report our single-institution experience with breast-conserving surgery (BCS) followed by intraoperative radiotherapy (IORT) as an alternative to salvage mastectomy for new or recurrent breast cancers that develop in the setting of prior thoracic radiation. METHODS: We performed an IRB-approved retrospective review of patients treated with breast IORT between September 2013 and November 2016...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28887747/reliability-and-validity-of-the-work-and-well-being-inventory-wbi-for-employees
#16
A A Vendrig, F G Schaafsma
Purpose The purpose of this study is to measure the psychometric properties of the Work and Wellbeing Inventory (WBI) (in Dutch: VAR-2), a screening tool that is used within occupational health care and rehabilitation. Our research question focused on the reliability and validity of this inventory. Methods Over the years seven different samples of workers, patients and sick listed workers varying in size between 89 and 912 participants (total: 2514), were used to measure the test-retest reliability, the internal consistency, the construct and concurrent validity, and the criterion and predictive validity...
September 8, 2017: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/28766757/sesamol-ameliorates-radiation-induced-dna-damage-in-hematopoietic-system-of-whole-body-%C3%AE-irradiated-mice
#17
Arun Kumar, Sandeep Choudhary, Jawahar S Adhikari, Nabo K Chaudhury
Ionizing radiation exposure is harmful and at high doses can lead to acute hematopoietic radiation syndrome. Therefore, agents that can protect hematopoietic system are important for development of radioprotector. Sesamol is a potential molecule for development of radioprotector due to its strong free radical scavenging and antioxidant properties. In the present study, sesamol was evaluated for its role in DNA damage and repair in hematopoietic system of γ-irradiated CB57BL/6 mice and compared with amifostine...
August 2, 2017: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/28766205/a-single-institution-retrospective-comparison-study-of-locoregional-recurrence-after-accelerated-partial-breast-irradiation-using-external-beam-fractionation-compared-with-whole-breast-irradiation-with-8%C3%A2-years-of-follow-up
#18
Shalin Shah, Alexandra Kyrillos, Kristine Kuchta, Hussain Habib, Megan Tobias, Vathsala Raghavan, Arif Shaikh, William Bloomer, Catherine Pesce, Katharine Yao
BACKGROUND: Accelerated partial breast irradiation (APBI) was developed to address disadvantages of overall treatment time and potentially unnecessary radiation associated with whole breast irradiation (WBI). We report updated results of our single institution study using an external beam APBI regimen with a median follow-up of 8 years. METHODS: A total of 290 APBI patients with AJCC Stage 0-II breast cancer were compared with 290 WBI patients with matched tumor characteristics...
August 1, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28756794/psychometric-properties-of-the-worry-behaviors-inventory-replication-and-extension-in-a-large-clinical-and-community-sample
#19
Alison E J Mahoney, Megan J Hobbs, Jill M Newby, Alishia D Williams, Gavin Andrews
BACKGROUND: The use of maladaptive behaviors by individuals with generalized anxiety disorder (GAD) is theoretically important and clinically meaningful. However, little is known about the specificity of avoidant behaviors to GAD and how these behaviors can be reliably assessed. AIMS: This study replicated and extended the psychometric evaluation of the Worry Behaviors Inventory (WBI), a brief self-report measure of avoidant behaviors associated with GAD. METHOD: The WBI was administered to a hospital-based sample of adults seeking treatment for symptoms of anxiety and/or depression (n = 639) and to a community sample (n = 55)...
July 31, 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/28751904/canopy-vegetation-indices-from-in-situ-hyperspectral-data-to-assess-plant-water-status-of-winter-wheat-under-powdery-mildew-stress
#20
Wei Feng, Shuangli Qi, Yarong Heng, Yi Zhou, Yapeng Wu, Wandai Liu, Li He, Xiao Li
Plant disease and pests influence the physiological state and restricts the healthy growth of crops. Physiological measurements are considered the most accurate way of assessing plant health status. In this paper, we researched the use of an in situ hyperspectral remote sensor to detect plant water status in winter wheat infected with powdery mildew. Using a diseased nursery field and artificially inoculated open field experiments, we detected the canopy spectra of wheat at different developmental stages and under different degrees of disease severity...
2017: Frontiers in Plant Science
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