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https://www.readbyqxmd.com/read/28766757/sesamol-ameliorates-radiation-induced-dna-damage-in-hematopoietic-system-of-whole-body-%C3%AE-irradiated-mice
#1
Arun Kumar, Sandeep Choudhary, Jawahar S Adhikari, Nabo K Chaudhury
Ionizing radiation exposure is harmful and at high doses can lead to acute hematopoietic radiation syndrome. Therefore, agents that can protect hematopoietic system are important for development of radioprotector. Sesamol is a potential molecule for development of radioprotector due to its strong free radical scavenging and antioxidant properties. In the present study, sesamol was evaluated for its role in DNA damage and repair in hematopoietic system of γ-irradiated CB57BL/6 mice and compared with amifostine...
August 2, 2017: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/28766205/a-single-institution-retrospective-comparison-study-of-locoregional-recurrence-after-accelerated-partial-breast-irradiation-using-external-beam-fractionation-compared-with-whole-breast-irradiation-with-8%C3%A2-years-of-follow-up
#2
Shalin Shah, Alexandra Kyrillos, Kristine Kuchta, Hussain Habib, Megan Tobias, Vathsala Raghavan, Arif Shaikh, William Bloomer, Catherine Pesce, Katharine Yao
BACKGROUND: Accelerated partial breast irradiation (APBI) was developed to address disadvantages of overall treatment time and potentially unnecessary radiation associated with whole breast irradiation (WBI). We report updated results of our single institution study using an external beam APBI regimen with a median follow-up of 8 years. METHODS: A total of 290 APBI patients with AJCC Stage 0-II breast cancer were compared with 290 WBI patients with matched tumor characteristics...
August 1, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28756794/psychometric-properties-of-the-worry-behaviors-inventory-replication-and-extension-in-a-large-clinical-and-community-sample
#3
Alison E J Mahoney, Megan J Hobbs, Jill M Newby, Alishia D Williams, Gavin Andrews
BACKGROUND: The use of maladaptive behaviors by individuals with generalized anxiety disorder (GAD) is theoretically important and clinically meaningful. However, little is known about the specificity of avoidant behaviors to GAD and how these behaviors can be reliably assessed. AIMS: This study replicated and extended the psychometric evaluation of the Worry Behaviors Inventory (WBI), a brief self-report measure of avoidant behaviors associated with GAD. METHOD: The WBI was administered to a hospital-based sample of adults seeking treatment for symptoms of anxiety and/or depression (n = 639) and to a community sample (n = 55)...
July 31, 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/28751904/canopy-vegetation-indices-from-in-situ-hyperspectral-data-to-assess-plant-water-status-of-winter-wheat-under-powdery-mildew-stress
#4
Wei Feng, Shuangli Qi, Yarong Heng, Yi Zhou, Yapeng Wu, Wandai Liu, Li He, Xiao Li
Plant disease and pests influence the physiological state and restricts the healthy growth of crops. Physiological measurements are considered the most accurate way of assessing plant health status. In this paper, we researched the use of an in situ hyperspectral remote sensor to detect plant water status in winter wheat infected with powdery mildew. Using a diseased nursery field and artificially inoculated open field experiments, we detected the canopy spectra of wheat at different developmental stages and under different degrees of disease severity...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28734822/icotinib-versus-whole-brain-irradiation-in-patients-with-egfr-mutant-non-small-cell-lung-cancer-and-multiple-brain-metastases-brain-a-multicentre-phase-3-open-label-parallel-randomised-controlled-trial
#5
Jin-Ji Yang, Caicun Zhou, Yisheng Huang, Jifeng Feng, Sun Lu, Yong Song, Cheng Huang, Gang Wu, Li Zhang, Ying Cheng, Chengping Hu, Gongyan Chen, Li Zhang, Xiaoqing Liu, Hong Hong Yan, Fen Lai Tan, Wenzhao Zhong, Yi-Long Wu
BACKGROUND: For patients with non-small-cell lung cancer (NSCLC) and multiple brain metastases, whole-brain irradiation (WBI) is a standard-of-care treatment, but its effects on neurocognition are complex and concerning. We compared the efficacy of an epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI), icotinib, versus WBI with or without chemotherapy in a phase 3 trial of patients with EGFR-mutant NSCLC and multiple brain metastases. METHODS: We did a multicentre, open-label, parallel randomised controlled trial (BRAIN) at 17 hospitals in China...
July 19, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28732369/efficacy-and-safety-of-accelerated-partial-breast-irradiation-a-meta-analysis-of-published-randomized-studies
#6
Gengchun Liu, Zhongyi Dong, Baqun Huang, Yuelong Liu, Yan Tang, Qing Li, Yihui Zhu
BACKGROUND AND PURPOSE: Accelerated partial breast irradiation (APBI) technology has theoretical advantages in comparison with traditional adjuvant radiation therapy (whole-breast irradiation; WBI) after breast-conserving surgery. However, published randomized controlled trials have shown inconsistent outcomes. Therefore, a comprehensive assessment of the effectiveness and safety of APBI technology is needed. RESULTS: A total of 7 studies of 7452 patients were included in this analysis...
July 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732024/4-nitrophenylsulfonyl-piperazines-mitigate-radiation-damage-to-multiple-tissues
#7
Ewa D Micewicz, Kwanghee Kim, Keisuke S Iwamoto, Josephine A Ratikan, Genhong Cheng, Gayle M Boxx, Robert D Damoiseaux, Julian P Whitelegge, Piotr Ruchala, Christine Nguyen, Prabhat Purbey, Joseph Loo, Gang Deng, Michael E Jung, James W Sayre, Andrew J Norris, Dörthe Schaue, William H McBride
Our ability to use ionizing radiation as an energy source, as a therapeutic agent, and, unfortunately, as a weapon, has evolved tremendously over the past 120 years, yet our tool box to handle the consequences of accidental and unwanted radiation exposure remains very limited. We have identified a novel group of small molecule compounds with a 4-nitrophenylsulfonamide (NPS) backbone in common that dramatically decrease mortality from the hematopoietic acute radiation syndrome (hARS). The group emerged from an in vitro high throughput screen (HTS) for inhibitors of radiation-induced apoptosis...
2017: PloS One
https://www.readbyqxmd.com/read/28712278/in-vivo-dosimetry-and-acute-toxicity-in-breast-cancer-patients-undergoing-intraoperative-radiotherapy-as-boost
#8
Jason Joon Bock Lee, Jinhyun Choi, Sung Gwe Ahn, Joon Jeong, Ik Jae Lee, Kwangwoo Park, Kangpyo Kim, Jun Won Kim
PURPOSE: To report the results of a correlation analysis of skin dose assessed by in vivo dosimetry and the incidence of acute toxicity. This is a phase 2 trial evaluating the feasibility of intraoperative radiotherapy (IORT) as a boost for breast cancer patients. MATERIALS AND METHODS: Eligible patients were treated with IORT of 20 Gy followed by whole breast irradiation (WBI) of 46 Gy. A total of 55 patients with a minimum follow-up of 1 month after WBI were evaluated...
June 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28697858/accelerated-partial-breast-irradiation-for-elderly-women-with-early-breast-cancer-a-compromise-between-whole-breast-irradiation-and-omission-of-radiotherapy
#9
Shakeel Sumodhee, Johan Levy, Emmanuel Chamorey, Daniel Lam Cham Kee, Marie-Eve Chand, Mathieu Gautier, Isabelle Peyrottes, Emmanuel Barranger, Jean-Michel Hannoun-Levi
PURPOSE: Regarding adjuvant radiation therapy making decision for elderly women, Albert (2013) published a nomogram predicting the mastectomy-free survival (MFS) rate with or without adjuvant irradiation. Based on this approach, we proposed to investigate the use of accelerated partial breast irradiation (APBI) vs. whole breast irradiation (WBI) or endocrine therapy alone in elderly low-risk breast cancer patients. METHODS AND MATERIALS: For each elderly woman treated by conserving surgery and APBI (multicatheter interstitial high-dose-rate brachytherapy), 5- and 10-year MFS rates were calculated...
July 8, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28678260/why-nanoscale-tank-treads-move-structures-chemical-bonding-and-molecular-dynamics-of-a-doped-boron-cluster-b10c
#10
Ying-Jin Wang, Jin-Chang Guo, Hua-Jin Zhai
Planar boron clusters form dynamic rotors, either as molecular Wankel motors or subnanoscale tank treads, the latter being exemplified by an elongated B11(-) cluster. For an in-depth mechanistic understanding of the rotors, we investigate herein a doped boron cluster, B10C, in which a C atom isovalently substitutes B(-) in the B11(-) tank tread. Two critical structures are achieved: the Cs ((1)A') global minimum (GM) with C positioned in the peripheral ring and the C2v ((1)A1) local minimum (LM) with C in the diatomic core...
July 13, 2017: Nanoscale
https://www.readbyqxmd.com/read/28629952/analysis-of-outcomes-using-hypofractionated-tumor-bed-boost-combined-with-hypofractionated-whole-breast-irradiation-for-early-stage-breast-cancer
#11
Esther Yu, David Huang, Kara Leonard, Thomas Dipetrillo, David Wazer, Jaroslaw Hepel
INTRODUCTION: Tumor bed boost improves local control and is an important part of breast-conserving therapy. Data on the use of a hypofractioned tumor bed boost are needed. We performed a retrospective analysis of patients treated with hypofractionated whole breast irradiation (WBI) and hypofractionated boost to examine acute and delayed outcomes. MATERIALS AND METHODS: We examined the records of patients treated with hypofractionated WBI and tumor bed boost after lumpectomy for Stage 0 to II breast cancer...
May 25, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28549483/whole-breast-and-regional-nodal-irradiation-in-prone-versus-supine-position-in-left-sided-breast-cancer
#12
Pieter Deseyne, Bruno Speleers, Wilfried De Neve, Bert Boute, Leen Paelinck, Tom Van Hoof, Joris Van de Velde, Annick Van Greveling, Chris Monten, Giselle Post, Herman Depypere, Liv Veldeman
BACKGROUND: Prone whole breast irradiation (WBI) leads to reduced heart and lung doses in breast cancer patients receiving adjuvant radiotherapy. In this feasibility trial, we investigated the prone position for whole breast + lymph node irradiation (WB + LNI). METHODS: A new support device was developed for optimal target coverage, on which patients are positioned in a position resembling a phase from the crawl swimming technique (prone crawl position)...
May 26, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28545957/irradiation-in-a-flash-unique-sparing-of-memory-in-mice-after-whole-brain-irradiation-with-dose-rates-above-100gy-s
#13
Pierre Montay-Gruel, Kristoffer Petersson, Maud Jaccard, Gaël Boivin, Jean-François Germond, Benoit Petit, Raphaël Doenlen, Vincent Favaudon, François Bochud, Claude Bailat, Jean Bourhis, Marie-Catherine Vozenin
This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate. Spatial memory is preserved after WBI with mean dose rates above 100Gy/s, whereas 10Gy WBI at a conventional radiotherapy dose rate (0.1Gy/s) totally impairs spatial memory.
May 22, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28482018/the-weight-bias-internalization-scale-for-youth-validation-of-a-specific-tool-for-assessing-internalized-weight-bias-among-treatment-seeking-german-adolescents-with-overweight
#14
Cristina Ciupitu-Plath, Susanna Wiegand, Birgit Babitsch
 The study aimed to assess the psychometric properties of a partly adapted, German version of the Weight Bias Internalization Scale (WBIS-Y) in a sample of treatment-seeking adolescents with overweight. A survey ( N  = 191), including measures of weight bias internalization (WBI), self-esteem, self-efficacy, health-related quality of life, and body-related locus of control, was followed by semistructured interviews ( N  = 10). Cronbach's α, correlation, and factor analyses were performed. Interview data were subjected to inductive content analysis...
May 8, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/28458578/intraoperative-radiation-therapy-for-breast-cancer-patients-current-perspectives
#15
REVIEW
Sunil W Dutta, Shayna L Showalter, Timothy N Showalter, Bruce Libby, Daniel M Trifiletti
Accelerated partial breast irradiation (APBI) provides an attractive alternative to whole breast irradiation (WBI) through normal tissue radiation exposure and reduced treatment duration. Intraoperative radiation therapy (IORT) is a form of APBI with the shortest time interval, as it delivers the entirety of a planned radiation course at the time of breast surgery. However, faster is not always better, and IORT has been met with healthy skepticism. Patients treated with IORT have an increased compliance and overall satisfaction when compared to patients treated with WBI...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28409233/effects-of-a%C3%A2-web-based-follow-up-intervention-on-self-efficacy-in-obesity-treatment-for-women
#16
Sonja Rader, Thomas Ernst Dorner, Rudolf Schoberberger, Hilde Wolf
Obesity is a chronic disease requiring long-term care. The purpose of the current study was the evaluation of a web-based intervention (WBI), subsequent to an initial face to face life style treatment. In a randomized trial, 84 women received an introduction phase (4 months) and a training phase (2 months) where one group was trained in using WBI whereas the other arm received a printed manual (PMI). During the self-monitoring phase (6 months) participants either used the WBI or the PMI for follow-up support...
July 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28377213/risk-factors-and-state-of-the-art-indications-for-boost-irradiation-in-invasive-breast-carcinoma
#17
REVIEW
Alfredo Polo, Csaba Polgár, Jean-Michel Hannoun-Levi, Jose-Luis Guinot, Cristina Gutierrez, Razvan Galalae, Erik van Limbergen, Vratislav Strnad
PURPOSE: The aim of the study was to give recommendations on patient selection criteria for the administration of boost doses after whole-breast irradiation (WBI) in invasive breast cancer based on available clinical evidence complemented by expert opinion. METHODS AND MATERIALS: A systematic search of the PubMed database was conducted to identify factors associated with increased risk for local failure that can define risk groups, and to provide evidence for an adequate guidance to the use of the boost as a function of the risk of local recurrence in breast-conserving therapy...
May 2017: Brachytherapy
https://www.readbyqxmd.com/read/28370002/angular-under-sampling-effect-on-vmat-dose-calculation-an-analysis-and-a-solution-strategy
#18
Ji-Yeon Park, Feifei Li, Jonathan Li, Darren Kahler, Justin C Park, Guanghua Yan, Chihray Liu, Bo Lu
PURPOSE: Most VMAT algorithms compute the dose on discretized apertures with small angular separations for practical reasons. However, machines deliver the VMAT dose with a continuously moving MLC and gantry and a continuously changing dose rate. The computed dose can deviate from the delivered dose, especially if no, or loose, MLC movement constraints are applied for the VMAT optimization. The goal of this paper is to establish a simplified mathematical model to analyze the discrepancy between the VMAT plan calculation dose and the delivered dose and to provide a reasonable solution for clinical implementation...
April 1, 2017: Medical Physics
https://www.readbyqxmd.com/read/28367276/the-effect-of-whole-brain-radiation-wbi-and-karnofsky-performance-status-kps-on-survival-of-patients-receiving-stereotactic-radiosurgery-srs-for-second-brain-metastatic-event
#19
D R Brown, R Lanciano, C Heal, A Hanlon, J Yang, J Feng, M Stanley, R Buonocore, A Okpaku, W Ding, S Arrigo, J Lamond, L Brady
OBJECTIVE: The objective of the present study is to analyze prognostic factors affecting survival of patients receiving stereotactic radiosurgery (SRS) for second brain metastatic event (SBME) following initial treatment with whole brain irradiation (WBI), surgical resection, or previous SRS. METHODS: The 88 patients treated with SRS for SBME at Philadelphia CyberKnife between January 2006 and October 2013 were included in the study group. Cox proportional-hazards regression was used to identify prognostic factors that significantly impacted survival from the time of SRS for SBME...
2017: Journal of Radiation Oncology
https://www.readbyqxmd.com/read/28333304/further-insights-into-the-impact-of-mouse-follicle-stage-on-graft-outcome-in-an-artificial-ovary-environment
#20
M C Chiti, M M Dolmans, C M Lucci, F Paulini, J Donnez, C A Amorim
STUDY QUESTION: Are mouse preantral follicles differently affected by isolation, encapsulation and/or grafting procedures according to stage? SUMMARY ANSWER: Isolated secondary follicles showed superior ability to survive and grow after transplantation, which was not related to a particular effect of the isolation and/or grafting procedure, but rather to their own ability to induce neoangiogenesis. WHAT IS KNOWN ALREADY: Isolated and encapsulated mouse preantral follicles can survive (6-27%) and grow (80-100%) in a fibrin matrix with a low concentration of fibrinogen and thrombin (F12...
June 1, 2017: Molecular Human Reproduction
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