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https://www.readbyqxmd.com/read/29764803/effectiveness-of-a-combined-web-based-and-ecological-momentary-intervention-for-incoming-first-year-university-students-protocol-for-a-3-arm-randomized-controlled-trial
#1
Benjamin C Riordan, Saleh Moradi, Kate B Carey, Tamlin S Conner, Kyungho Jang, Kelly E Reid, Damian Scarf
BACKGROUND: Alcohol use among university students is common, and those who drink often choose to drink heavily (ie, 4 or more drinks per session for women or 5 or more for men). Web-based interventions (WBIs), in which students complete assessments and receive personalized feedback about their alcohol use, and ecological momentary interventions (EMIs), which use mobile devices as a method of delivering intervention information, are 2 methods that have had some success in reducing alcohol use among university students...
May 15, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29697840/validating-the-efficacy-of-single-stage-breast-conserving-therapy-using-multicatheter-partial-breast-brachytherapy-based-on-updated-astro-guidelines
#2
Kazuhiko Sato, Hiromi Fuchikami, Naoko Takeda, Masahiro Kato, Takahiro Shimo, Tomohiko Okawa
Based on the accumulating evidence for equivalent results of partial-breast irradiation (PBI) and whole-breast irradiation (WBI) in breast-conserving therapy (BCT), the American Society for Radiation Oncology (ASTRO) updated the consensus statement (CS) to expand the range of potential candidates for PBI outside clinical trials. Of the various techniques, PBI using multicatheter interstitial brachytherapy (MCB) is the oldest and has long-term data. In this study, the efficacy of single-stage BCT using MCB-PBI achieved by an intraoperative catheter placement was validated on updated ASTRO guidelines...
April 25, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/29695570/predicting-survival-after-whole-brain-irradiation-for-cerebral-metastases-in-patients-with-cancer-of-the-bladder
#3
Dirk Rades, Liesa Dziggel, Lisa Manig, Stefan Janssen, Mai Trong Khoa, Vuong Ngoc Duong, Vu Huu Khiem, Steven E Schild
BACKGROUND/AIM: This study aimed to create a predictive tool for estimating the remaining lifespan of patients after whole-brain irradiation (WBI) for cerebral metastases from bladder cancer. PATIENTS AND METHODS: In 34 of these patients clinical parameters were analyzed for survival including age at start of WBI, gender, Karnofsky score, number of cerebral metastases and involvement of extra-cranial sites of metastasis. RESULTS: Involvement of extra-cranial sites (14%) and Karnofsky score (9%) showed the greatest difference regarding 6-month survival and were considered for the tool...
May 2018: In Vivo
https://www.readbyqxmd.com/read/29656285/sociocultural-and-familial-factors-associated-with-weight-bias-internalization
#4
Rebecca L Pearl, Thomas A Wadden, Jena Shaw Tronieri, Ariana M Chao, Naji Alamuddin, Zayna M Bakizada, Emilie Pinkasavage, Robert I Berkowitz
BACKGROUND/AIMS: Sociocultural and familial factors associated with weight bias internalization (WBI) are currently unknown. The present study explored the relationship between interpersonal sources of weight stigma, family weight history, and WBI. METHODS: Participants with obesity (N = 178, 87.6% female, 71.3% black) completed questionnaires that assessed the frequency with which they experienced weight stigma from various interpersonal sources. Participants also reported the weight status of their family members and completed measures of WBI, depression, and demographics...
April 14, 2018: Obesity Facts
https://www.readbyqxmd.com/read/29623550/evaluation-of-adaptive-radiotherapy-art-by-use-of-replanning-the-tumor-bed-boost-with-repeated-computed-tomography-ct-simulation-after-whole-breast-irradiation-wbi-for-breast-cancer-patients-having-clinically-evident-seroma
#5
Omer Sager, Ferrat Dincoglan, Bora Uysal, Selcuk Demiral, Hakan Gamsiz, Yelda Elcim, Esin Gundem, Bahar Dirican, Murat Beyzadeoglu
PURPOSE: The aim of this study is to evaluate adaptive radiotherapy (ART) by use of replanning the tumor bed boost with repeated computed tomography (CT) simulation after whole breast irradiation (WBI) for breast cancer patients having clinically evident seroma. MATERIALS AND METHODS: Forty-eight patients with clinically evident seroma at the time of planning CT simulation for WBI were included. Two RT treatment plannings were generated for each patient based on the initial CT simulation and tumor bed boost CT simulation to assess seroma and boost target volume (BTV) changes during WBI...
April 5, 2018: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29599370/predictive-factors-for-local-control-and-survival-in-patients-with-cancer-of-unknown-primary-cup-irradiated-for-cerebral-metastases
#6
Dirk Rades, Liesa Dziggel, Stefan Janssen, Mai Trong Khoa, Vuong Ngoc Duong, Vu Huu Khiem, Niklas Gebauer, Tobias Bartscht, Steven E Schild
BACKGROUND/AIM: To identify predictors of local control and survival after whole-brain irradiation (WBI) for cerebral metastases from cancer of unknown primary (CUP). PATIENTS AND METHODS: In 140 patients receiving WBI alone or following resection, seven factors were investigated including treatment approach, WBI-regimen, age, gender, Eastern Cooperative Oncology Group (ECOG) performance score, number of cerebral lesions and extra-cerebral metastases. RESULTS: On univariate analysis, resection plus WBI and boost (p=0...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29571855/quantification-of-whole-body-bradykinesia-in-parkinson-s-disease-participants-using-multiple-inertial-sensors
#7
Sara Memar, Mehdi Delrobaei, Marcus Pieterman, Kenneth McIsaac, Mandar Jog
Bradykinesia (slowness of movement) is a common motor symptom of Parkinson's disease (PD) that can severely affect quality of life for those living with the disease. Assessment and treatment of PD motor symptoms largely depends on clinical scales such as the Unified Parkinson's Disease Rating Scale (UPDRS). However, such clinical scales rely on the visual assessment by a human observer, naturally resulting in inter-rater variability. Although previous studies have developed objective means for measuring bradykinesia in PD patients, their evaluation was restricted by the type of movement and number of joints assessed...
April 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29553003/maladaptive-behaviours-associated-with-generalized-anxiety-disorder-an-item-response-theory-analysis
#8
Alison E J Mahoney, Megan J Hobbs, Jill M Newby, Alishia D Williams, Gavin Andrews
BACKGROUND: Cognitive models of generalized anxiety disorder (GAD) suggest that maladaptive behaviours may contribute to the maintenance of the disorder; however, little research has concentrated on identifying and measuring these behaviours. To address this gap, the Worry Behaviors Inventory (WBI) was developed and has been evaluated within a classical test theory (CTT) approach. AIMS: As CTT is limited in several important respects, this study examined the psychometric properties of the WBI using an Item Response Theory approach...
March 19, 2018: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/29548340/utilizing-clinical-pathways-and-web-based-conferences-to-improve-quality-of-care-in-a-large-integrated-network-using-breast-cancer-radiation-therapy-as-the-model
#9
Katherine S Chen, Scott M Glaser, Allison E Garda, John A Vargo, M Saiful Huq, Dwight E Heron, Sushil Beriwal
BACKGROUND: Clinical pathways outline criteria for dose homogeneity and critical organ dosimetry. Based upon an internal audit showing suboptimal compliance with dosimetric parameters in whole breast irradiation (WBI), we conducted a mandatory web-based teaching conference for the network. This study reports the impact of this initiative on subsequent treatment plans. METHODS: Radiation treatment plans were collected for the 10 most recent patients receiving WBI at 16 institutions within the UPMC Hillman Cancer Center network...
March 16, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29545124/radiation-therapy-for-the-whole-breast-executive-summary-of-an-american-society-for-radiation-oncology-astro-evidence-based-guideline
#10
Benjamin D Smith, Jennifer R Bellon, Rachel Blitzblau, Gary Freedman, Bruce Haffty, Carol Hahn, Francine Halberg, Karen Hoffman, Kathleen Horst, Jean Moran, Caroline Patton, Jane Perlmutter, Laura Warren, Timothy Whelan, Jean L Wright, Reshma Jagsi
INTRODUCTION: The purpose of this guideline is to offer recommendations on fractionation for whole breast irradiation (WBI) with or without a tumor bed boost and guidance on treatment planning and delivery. METHODS AND MATERIALS: The American Society for Radiation Oncology (ASTRO) convened a task force to address 5 key questions focused on dose-fractionation for WBI, indications and dose-fractionation for tumor bed boost, and treatment planning techniques for WBI and tumor bed boost...
March 8, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29522691/a-multifaceted-investigation-into-the-effects-of-acute-exercise-on-indices-of-brain-function
#11
Jeremy J Walsh
Participation in regular exercise is important for the maintenance and improvement of brain health across the lifespan. These beneficial effects are realized almost immediately, as a single bout of exercise transiently improves cognitive function after cessation from exercise. This postexercise time period represents an opportunity to strategically prescribe cognitively stimulating activities for enhancing brain plasticity and function. Mechanistically, acute exercise is proposed to upregulate brain-derived neurotrophic factor (BDNF) expression and increase regional activation and arousal of brain areas involved in cognitive control; however, the specific mechanisms underlying this facilitation are poorly understood...
March 9, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29515101/synergistic-actions-of-fgf2-and-bone-marrow-transplantation-mitigate-radiation-induced-intestinal-injury
#12
Byoung Hyuck Kim, Hee-Won Jung, Seok Hyun Seo, Hyemi Shin, Jeanny Kwon, Jae Myoung Suh
Unwanted radiological or nuclear exposure remains a public health risk for which effective therapeutic countermeasures are lacking. Here, we evaluated the efficacy of fibroblast growth factor-2 (FGF2) in treating radiation-induced gastrointestinal syndrome (RIGS) incurred by lethal whole-body irradiation (WBI) when administered in conjunction with bone marrow transplantation (BMT). In vitro experiments indicated FGF2 treatment increased proliferation, reduced apoptosis, and upregulated AKT-GSK3β/β-catenin signaling in irradiated IEC-6 cells...
March 7, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29485078/hippocampal-sparing-during-craniospinal-irradiation-what-did-we-learn-about-the-incidence-of-perihippocampus-metastases
#13
Laetitia Padovani, Frédérique Chapon, Nicolas André, Mohamed Boucekine, Anne Geoffray, Franck Bourdeau, Julien Masliah-Planchon, Line Claude, Aymeri Huchet, Anne Laprie, Stephane Supiot, Bernard Coche-Dequéant, Christine Kerr, Claire Alapetite, Julie Leseur, Tandat Nguyen, Sophie Chapet, Valerie Bernier, Pierre-Yves Bondiau, Georges Noel, Jean Louis Habrand, Stephanie Bolle, François Doz, Christelle Dufour, Xavier Muracciole, Christian Carrie
PURPOSE: To identify the incidence of patients with perihippocampal metastases to assess the risk of brain relapse when sparing the hippocampal area. Medulloblastoma (MB) represents 20% of pediatric brain tumors. For high-risk MB patients, the 3- to 5-year event-free survival rate has recently improved from 50% to >76%. Many survivors, however, experience neurocognitive side effects. Several retrospective studies of patients receiving whole brain irradiation (WBI) have suggested a relationship between the radiation dose to the hippocampus and neurocognitive decline...
March 15, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29485067/long-term-patient-reported-outcomes-in-older-breast-cancer-survivors-a-population-based-survey-study
#14
Cameron W Swanick, Xiudong Lei, Ying Xu, Yu Shen, Nathan A Goodwin, Grace L Smith, Sharon H Giordano, Kelly K Hunt, Reshma Jagsi, Simona F Shaitelman, Susan K Peterson, Benjamin D Smith
PURPOSE: For older women with breast cancer, local therapy options may include lumpectomy plus whole-breast irradiation (Lump + WBI), lumpectomy plus brachytherapy (Lump + Brachy), lumpectomy alone (Lump alone), mastectomy without radiation therapy (Mast alone), and mastectomy plus radiation therapy (Mast + RT). We surveyed a population-based cohort of older breast cancer survivors to assess the association of local therapy with long-term quality-of-life outcomes. METHODS AND MATERIALS: We used nationally comprehensive Medicare claims to identify women aged ≥67 years in whom nonmetastatic breast cancer was diagnosed in 2009, who were treated with 1 of the 5 aforementioned treatment options, and who were still alive in 2015...
March 15, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29349713/patient-reported-outcomes-of-catheter-based-accelerated-partial-breast-brachytherapy-and-whole-breast-irradiation-a-single-institution-experience
#15
Krishan R Jethwa, Mohamed M Kahila, Kristin C Mara, William S Harmsen, David M Routman, Geralyn M Pumper, Kimberly S Corbin, Jeff A Sloan, Kathryn J Ruddy, Tina J Hieken, Sean S Park, Robert W Mutter
PURPOSE: Accelerated partial breast irradiation (APBI) and whole breast irradiation (WBI) are treatment options for early-stage breast cancer. The purpose of this study was to compare patient-reported-outcomes (PRO) between patients receiving multi-channel intra-cavitary brachytherapy APBI or WBI. METHODS: Between 2012 and 2015, 131 patients with ductal carcinoma in situ (DCIS) or early stage invasive breast cancer were treated with adjuvant APBI (64) or WBI (67) and participated in a PRO questionnaire...
May 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29342297/an-exact-goodness-of-fit-test-based-on-the-occupancy-problems-to-study-zero-inflation-and-zero-deflation-in-biological-dosimetry-data
#16
Amanda Fernández-Fontelo, Pedro Puig, Elizabeth A Ainsbury, Manuel Higueras
The goal in biological dosimetry is to estimate the dose of radiation that a suspected irradiated individual has received. For that, the analysis of aberrations (most commonly dicentric chromosome aberrations) in scored cells is performed and dose response calibration curves are built. In whole body irradiation (WBI) with X- and gamma-rays, the number of aberrations in samples is properly described by the Poisson distribution, although in partial body irradiation (PBI) the excess of zeros provided by the non-irradiated cells leads, for instance, to the Zero-Inflated Poisson distribution...
January 12, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29332158/combined-sublethal-irradiation-and-agonist-anti-cd40-enhance-donor-t-cell-accumulation-and-control-of-autochthonous-murine-pancreatic-tumors
#17
Lindsay K Ward-Kavanagh, Kathleen M Kokolus, Timothy K Cooper, Aron E Lukacher, Todd D Schell
Tumor-reactive T lymphocytes can promote the regression of established tumors. However, their efficacy is often limited by immunosuppressive mechanisms that block T cell accumulation or function. ACT provides the opportunity to ameliorate immune suppression prior to transfer of tumor-reactive T cells to improve the therapeutic benefit. We evaluated the combination of lymphodepleting whole body irradiation (WBI) and agonist anti-CD40 (αCD40) antibody on control of established autochthonous murine neuroendocrine pancreatic tumors following the transfer of naïve tumor-specific CD8 T cells...
April 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29299946/a-new-approach-for-modeling-patient-overall-radiosensitivity-and-predicting-multiple-toxicity-endpoints-for-breast-cancer-patients
#18
Chamberlain Mbah, Kim De Ruyck, Silke De Schrijver, Charlotte De Sutter, Kimberly Schiettecatte, Chris Monten, Leen Paelinck, Wilfried De Neve, Hubert Thierens, Catharine West, Gustavo Amorim, Olivier Thas, Liv Veldeman
INTRODUCTION: Evaluation of patient characteristics inducing toxicity in breast radiotherapy, using simultaneous modeling of multiple endpoints. METHODS AND MATERIALS: In 269 early-stage breast cancer patients treated with whole-breast irradiation (WBI) after breast-conserving surgery, toxicity was scored, based on five dichotomized endpoints. Five logistic regression models were fitted, one for each endpoint and the effect sizes of all variables were estimated using maximum likelihood (MLE)...
January 4, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29282078/short-course-hypofractionated-whole-breast-irradiation-after-conservative-surgery-a-single-institution-phase-ii-study
#19
Paola Pinnarò, Carolina Giordano, Alessia Farneti, Adriana Faiella, Giuseppe Iaccarino, Valeria Landoni, Diana Giannarelli, Patrizia Vici, Lidia Strigari, Giuseppe Sanguineti
BACKGROUND: To assess the oncologic outcomes of hypofractionated whole breast irradiation (Hypo-WBI). METHODS: Eligible patients had undergone breast conservative surgery for early breast cancer (pTis-2) and none/limited nodal involvement. Hypo-WBI consisted of 34 Gy in 10 daily fractions over 2 weeks to the whole breast three-dimensional conformal radiotherapy (3DCRT), followed by a single fraction of 8 Gy to the tumor bed after 1 week (electrons). Primary endpoint is freedom from ipsilateral breast tumor recurrence (IBTR)...
December 27, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29251449/determining-the-optimal-cut-off-scores-for-the-workplace-bullying-inventory
#20
Marie Hutchinson, Joanne Bradbury, Graeme Browne, John Hurley
BACKGROUND: Over the past two decades, there has been considerable research into workplace bullying. One area that remains poorly developed is a tool with the capacity to accurately differentiate between exposed and unexposed employees. AIM: To determine optimal cut-off scores for the Workplace Bullying Inventory (WBI) that accurately classify cases of exposure to workplace bullying. DISCUSSION: Secondary analysis of data collected from Australian public sector employees ( n =2,197) was conducted...
December 18, 2017: Nurse Researcher
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