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Thyroid associated orbitopathy

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https://www.readbyqxmd.com/read/29873029/selenoproteins-in-human-body-focus-on-thyroid-pathophysiology
#1
REVIEW
Ana Valea, Carmen Emanuela Georgescu
Selenium (Se) has a multilevel, complex and dynamic effect on the human body as a major component of selenocysteine, incorporated into selenoproteins, which include the selenocysteine-containing enzymes iodothyronine deiodinases. At the thyroid level, these proteins play an essential role in antioxidant protection and hormone metabolism. This is a narrative review based on PubMed/Medline database research regarding thyroid physiology and conditions with Se and Se-protein interferences. In humans, Se-dependent enzyme functions are best expressed through optimal Se intake, although there is gap in our knowledge concerning the precise mechanisms underlying the interrelation...
June 5, 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29768627/tsh-receptor-antibodies-may-prevent-bone-loss-in-pre-and-postmenopausal-women-with-graves-disease-and-graves-orbitopathy
#2
Mira Siderova, Kiril Hristozov, Aleksandra Tsukeva
OBJECTIVE: Thyrotoxicosis is established risk factor for osteoporosis due to increased bone turnover. Glucocorticoids often administered for Graves' orbitopathy (GO) have additional negative effect on bone mineral density (BMD). Our aim was to examine the influence of thyroid hormones, TSH, TSH-receptor antibodies (TRAb) and glucocorticoid treatment on bone in women with Graves' thyrotoxicosis and Graves' orbitopathy (GO). SUBJECTS AND METHODS: Forty seven women with Graves' disease, mean age 55...
March 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29736194/thyroid-associated-orbitopathy-and-biomarkers-where-we-are-and-what-we-can-hope-for-the-future
#3
REVIEW
Natacha Turck, Simone Eperon, Maria De Los Angeles Gracia, Aurélie Obéric, Mehrad Hamédani
Background: Thyroid-associated orbitopathy (TAO) is the most common autoimmune disease of the orbit. It occurs more often in patients presenting with hyperthyroidism, characteristic of Graves' disease, but may be associated with hypothyroidism or euthyroidism. The diagnosis of TAO is based on clinical orbital features, radiological criteria, and the potential association with thyroid disease. To date, there is no specific marker of the orbital disease, making the early diagnosis difficult, especially if the orbital involvement precedes the thyroid dysfunction...
2018: Disease Markers
https://www.readbyqxmd.com/read/29729448/quality-of-life-and-neuropsychiatric-disorders-in-patients-with-graves-orbitopathy-current-concepts
#4
REVIEW
Alice Bruscolini, Marta Sacchetti, Maurizio La Cava, Marcella Nebbioso, Angela Iannitelli, Adele Quartini, Alessandro Lambiase, Massimo Ralli, Armando de Virgilio, Antonio Greco
Graves' disease (GD) is an autoimmune chronic thyroiditis frequently associated with development of Graves' orbitopathy (GO) characterized by proptosis, strabismus, impairment of visual function, ocular surface inflammation and dry eye. As consequence, patients with GO experience impairment of quality of life and social function and could develop a neurobehavioral syndrome, ranging from anxious to depressive or psychotic disorders. To date, the pathogenic mechanism underlying neuropsychiatric disorders in patients with GD has not been clearly understood...
May 2, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29666119/depot-specific-characteristics-of-adipose-tissue-derived-stromal-cells-in-thyroid-associated-orbitopathy
#5
Janice Siu Chong Wong, Wai Kit Chu, Benjamin Fuk-Loi Li, Chi-Pui Pang, Kelvin Kam-Lung Chong
BACKGROUND: Thyroid-associated orbitopathy (TAO) causes inflammatory fibroproliferation of periocular connective tissues. We compared adipose tissue-derived stem/stromal cells (ADSCs) from three adipose depots of each patient with TAO on mesenchymal, myofibrogenic, adipogenic properties and associated hyaluronan (HA) synthesis. METHODS: ADSCs were generated from periocular (eyelid, orbital) and subcutaneous (abdominal) adipose tissues of three patients with TAO...
April 17, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29593440/graves-disease-in-central-ghana-clinical-characteristics-and-associated-factors
#6
Osei Sarfo-Kantanka, Fred Stephen Sarfo, Eunice Oparebea Ansah, Ishmael Kyei
Background: Graves disease (GD) has increased in prevalence over the past decade in Africa. Despite this, the condition is not well described, especially in sub-Saharan Africa. Objective: We have described the clinical characteristics and associated factors of GD in a cohort of patients attending a resource-limited setting tertiary hospital. Methods: Patients were examined thoroughly and systematically tested for the degree of clinical and biochemical thyroid status...
2018: Clinical Medicine Insights. Endocrinology and Diabetes
https://www.readbyqxmd.com/read/29546054/serum-trace-elements-profile-in-graves-disease-patients-with-or-without-orbitopathy-in-northeast-china
#7
Yongping Liu, Shanshan Liu, Jinyuan Mao, Sichen Piao, Jing Qin, Shiqiao Peng, Xiaochen Xie, Haixia Guan, Yushu Li, Zhongyan Shan, Weiping Teng
Objective: The purpose of the present study was to investigate serum trace elements in Graves' disease (GD) patients with or without orbitopathy in Northeast China. Methods: Patients with newly diagnosed Graves' disease (HyGD) ( n = 66), GD patients with euthyroid status or subclinical thyroidism after treatment (EUGD) ( n = 55), GO patients with euthyroid status or subclinical thyroidism after treatment (GO) ( n = 57), and normal controls (NC) ( n = 66) were enrolled in this study...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29521049/elevated-serum-concentrations-of-metalloproteinases-mmp-2-mmp-9-and-their-inhibitors-timp-1-timp-2-in-patients-with-graves-orbitopathy
#8
Katarzyna Kapelko-Słowik, Mirosław Słowik, Marek Szaliński, Jarosław Dybko, Dariusz Wołowiec, Iwona Prajs, Anna Bohdanowicz-Pawlak, Monika Biernat, Donata Urbaniak-Kujda
BACKGROUND: Graves' orbitopathy (GO), also known as thyroid-associated ophthalmopathy, is characterized by dramatic tissue reactivity. Both inflammation and tissue remodeling characterize the clinical course of GO. Some data has been found regarding the association of MMPs and TIMPs in GO. MATERIAL AND METHODS: Serum concentrations of MMP-9, MMP-2, TIMP-1, and TIMP-2 were determined by ELISA method. OBJECTIVES: Forty-eight patients (34 females, 14 males, with median age 51...
January 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29422752/epidemiology-and-clinical-features-of-thyroid-associated-orbitopathy-in-accra
#9
Edith Mawunyo Ackuaku-Dogbe, Josephine Akpalu, Benjamin Abaidoo
PURPOSE: Thyroid-associated orbitopathy (TAO), a clinical manifestation of Graves' disease, is an autoimmune disorder of the orbital and periorbital tissue. Data on the epidemiology and clinical presentation of TAO in Africa are generally scarce and unavailable in Ghana. We investigated the epidemiology and clinical features of TAO among patients with thyroid disorders attending the Korle Bu Teaching Hospital, Accra. SUBJECTS AND METHODS: This was a descriptive cross-sectional study of patients diagnosed with thyroid disorders which was conducted at the endocrine and orbital clinics of the Korle Bu Teaching Hospital...
October 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/29391576/change-in-eyelid-parameters-after-orbital-decompression-in-thyroid-associated-orbitopathy
#10
Hong Hyun Park, Yeoun Sook Chun, Nam Ju Moon, Jee Taek Kim, Sang Joon Park, Jeong Kyu Lee
PURPOSE: To investigate quantitative changes in eyelid parameters after orbital decompression surgery in thyroid-associated orbitopathy using the PC-based program, Eyelid Analysis Software (EAS). METHODS: This study included 202 eyes of 109 thyroid-associated orbitopathy patients. Digital photographs of the patients in primary gaze were taken just before and after orbital decompression surgery, and exophthalmos degree was measured by Hertel exophthalmometry (Hertel Exophthalmometer SKU:52400; Oculus, Arlington, VA, USA)...
February 2, 2018: Eye
https://www.readbyqxmd.com/read/29381976/thyroid-associated-orbitopathy-in-patients-with-thyroid-carcinoma-a-case-report-of-5-cases
#11
Peng Yu, Siyue Liu, Xinrong Zhou, Teng Huang, Yaling Li, Hong Wang, Gang Yuan
RATIONALE: Thyroid-associated orbitopathy (TAO) is most often seen in patients with autoimmune thyroid disease. Data about TAO occurred in patients with thyroid carcinoma are rare. We give a report of 5 patients to present the clinical characteristics, treatment, and prognosis of this type of case. PATIENT CONCERNS: Five thyroid carcinoma patients presented with orbitopathy. Among them, two patients (patient 1 and 4) were hyperthyroid and TSH receptor antibody (TRAb) positive, two patients (patient 3 and 5) were euthyroid and displayed slightly elevated TRAb titres, one patient (patient 2) was euthyroid and TRAb negative...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29377287/multimodal-assessment-of-orbital-immune-cell-infiltration-and-tissue-remodeling-during-development-of-graves-disease-by-1-h-19-f-mri
#12
Ulrich Flögel, Anke Schlüter, Christoph Jacoby, Sebastian Temme, J Paul Banga, Anja Eckstein, Jürgen Schrader, Utta Berchner-Pfannschmidt
PURPOSE: To evaluate key molecular and cellular features of Graves orbitopathy (GO) by simultaneous monitoring of alterations in morphology, inflammatory patterns, and tissue remodeling. METHODS: To this end, we utilized a murine model of GO induced by immunization with a human thyroid-stimulating hormone receptor A-subunit plasmid. Altogether, 52 mice were used: 27 GOs and 25 controls (Ctrl) immunized with β-galactasidose plasmid. From these, 17 GO and 12 Ctrl mice were subjected to multimodal MRI at 9...
August 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29373659/simultaneous-aesthetic-eyelid-surgery-and-orbital-decompression-for-rehabilitation-of-thyroid-eye-disease-the-one-stage-approach
#13
Francesco P Bernardini, Brent Skippen, Alessandra Zambelli, Benjamin Riesco, Martin H Devoto
Background: Aesthetic rehabilitation of thyroid orbitopathy includes orbital decompression, correction of eyelid retraction and aesthetic blepharoplasty, performed traditionally in separate stages. Objectives: To report the results of orbital decompression surgery associated with aesthetic eyelid surgery in one stage for aesthetic rehabilitation of patients affected by thyroid eye disease. Methods: Retrospective, multi centric study including 40 consecutive patients, who underwent orbital decompression surgery associated with aesthetic eyelid surgery in two centers: Genova (Group 1) + Buenos Aires (Group 2)...
January 24, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29334744/-selenium-treatment-in-thyreopathies
#14
Štefan Sotak
Selenium (latin Selenium) is a micronutrient embedded in several proteins. In adults, the thyroid is the organ with the highest amount of selenium per gram of tissue. Selenium levels in the body depend on the characteristics of the population and its diet and geographic area. In the thyroid, selenium is required for the antioxidant function and for the metabolism of thyroid hormones. The literature suggests that selenium supplementation of patients with Hashimotos thyroiditis is associated with a reduction in antithyroperoxidase antibody levels...
December 0: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29332250/the-levels-of-12-cytokines-and-growth-factors-in-tears-hyperthyreosis-vs-euthyreosis
#15
Jelena Juri Mandić, Ana Kozmar, Sanja Kusačić-Kuna, Anamarija Jazbec, Krešimir Mandić, Danijela Mrazovac, Nenad Vukojević
PURPOSE: Simultaneous analyses of the contents and ratios of 12 cytokines and growth factors in single samples of human tears were performed, and the results were compared between a group of healthy subjects and a group of patients with Graves' hyperthyreosis (GH) without thyroid-associated orbitopathy (TAO). METHODS: Determinations and concentration measurements of interleukins (IL-2, IL4, IL-6, IL-8, IL-10, IL-1α, and IL-1β) interferon (IFN-γ), tumor necrosis factor (TNF-α), monocyte chemoattractant protein (MCP-1), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF) were performed with single tear samples from 21 patients with hyperthyreosis and 22 healthy subjects...
April 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29330045/thyroid-associated-orbitopathy-when-should-we-operate
#16
REVIEW
Stuart R Seiff, Lilly H Wagner
No abstract text is available yet for this article.
January 9, 2018: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29260102/tocilizumab-as-a-steroid-sparing-agent-for-the-treatment-of-graves-orbitopathy
#17
David J Russell, Lilly H Wagner, Stuart R Seiff
Purpose: To describe the effect of tocilizumab in two patients with thyroid associated orbitopathy (TAO). Observations: We present two patients with TAO who could not tolerate corticosteroids and had a reduction in clinical and laboratory markers of inflammatory activity with subsequent tocilizumab therapy. Conclusions and importance: The IL-6 receptor antibody tocilizumab is a promising candidate for the treatment of TAO because it selectively targets a key inflammatory mediator and has a favorable side effect profile...
September 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29214313/rna-sequencing-gene-expression-profiling-of-orbital-adipose-derived-stem-cell-population-implicate-hox-genes-and-wnt-signaling-dysregulation-in-the-pathogenesis-of-thyroid-associated-orbitopathy
#18
Wensi Tao, Juan A Ayala-Haedo, Matthew G Field, Daniel Pelaez, Sara T Wester
Purpose: The purpose of this study was to characterize the intrinsic cellular properties of orbital adipose-derived stem cells (OASC) from patients with thyroid-associated orbitopathy (TAO) and healthy controls. Methods: Orbital adipose tissue was collected from a total of nine patients: four controls and five patients with TAO. Isolated OASC were characterized with mesenchymal stem cell-specific markers. Orbital adipose-derived stem cells were differentiated into three lineages: chondrocytes, osteocytes, and adipocytes...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29182030/biomarkers-of-ocular-surface-disease-using-impression-cytology
#19
REVIEW
Suzanne Hagan
Impression cytology (IC) is a technique which permits the retrieval of the outermost layer of ocular surface cells via the use of various types of filters. It is a minimally invasive method of evaluating human conjunctival epithelial cell morphology in the diagnosis of dry eye disease, a common and distressing disorder associated with ageing, contact lens wear, autoimmune disorders and refractive (LASIK) surgery. IC may also be utilized in the diagnosis of other ocular diseases, such as keratoconus and thyroid orbitopathy...
December 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29151039/pretibial-myxoedema-without-thyroid-associated-orbitopathy-in-a-patient-with-graves-disease
#20
Sailesh Lodha, Nimisha Jain, Anil Bhansali
No abstract text is available yet for this article.
April 2018: Postgraduate Medical Journal
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