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Thyroid associated orbitopathy

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https://www.readbyqxmd.com/read/29422752/epidemiology-and-clinical-features-of-thyroid-associated-orbitopathy-in-accra
#1
Edith Mawunyo Ackuaku-Dogbe, Josephine Akpalu, Benjamin Abaidoo
PURPOSE: Thyroid-associated orbitopathy (TAO), a clinical manifestation of Graves' disease, is an autoimmune disorder of the orbital and periorbital tissue. Data on the epidemiology and clinical presentation of TAO in Africa are generally scarce and unavailable in Ghana. We investigated the epidemiology and clinical features of TAO among patients with thyroid disorders attending the Korle Bu Teaching Hospital, Accra. SUBJECTS AND METHODS: This was a descriptive cross-sectional study of patients diagnosed with thyroid disorders which was conducted at the endocrine and orbital clinics of the Korle Bu Teaching Hospital...
October 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/29391576/change-in-eyelid-parameters-after-orbital-decompression-in-thyroid-associated-orbitopathy
#2
Hong Hyun Park, Yeoun Sook Chun, Nam Ju Moon, Jee Taek Kim, Sang Joon Park, Jeong Kyu Lee
PURPOSE: To investigate quantitative changes in eyelid parameters after orbital decompression surgery in thyroid-associated orbitopathy using the PC-based program, Eyelid Analysis Software (EAS). METHODS: This study included 202 eyes of 109 thyroid-associated orbitopathy patients. Digital photographs of the patients in primary gaze were taken just before and after orbital decompression surgery, and exophthalmos degree was measured by Hertel exophthalmometry (Hertel Exophthalmometer SKU:52400; Oculus, Arlington, VA, USA)...
February 2, 2018: Eye
https://www.readbyqxmd.com/read/29381976/thyroid-associated-orbitopathy-in-patients-with-thyroid-carcinoma-a-case-report-of-5-cases
#3
Peng Yu, Siyue Liu, Xinrong Zhou, Teng Huang, Yaling Li, Hong Wang, Gang Yuan
RATIONALE: Thyroid-associated orbitopathy (TAO) is most often seen in patients with autoimmune thyroid disease. Data about TAO occurred in patients with thyroid carcinoma are rare. We give a report of 5 patients to present the clinical characteristics, treatment, and prognosis of this type of case. PATIENT CONCERNS: Five thyroid carcinoma patients presented with orbitopathy. Among them, two patients (patient 1 and 4) were hyperthyroid and TSH receptor antibody (TRAb) positive, two patients (patient 3 and 5) were euthyroid and displayed slightly elevated TRAb titres, one patient (patient 2) was euthyroid and TRAb negative...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29377287/multimodal-assessment-of-orbital-immune-cell-infiltration-and-tissue-remodeling-during-development-of-graves-disease-by-1-h19-f-mri
#4
Ulrich Flögel, Anke Schlüter, Christoph Jacoby, Sebastian Temme, J Paul Banga, Anja Eckstein, Jürgen Schrader, Utta Berchner-Pfannschmidt
PURPOSE: To evaluate key molecular and cellular features of Graves orbitopathy (GO) by simultaneous monitoring of alterations in morphology, inflammatory patterns, and tissue remodeling. METHODS: To this end, we utilized a murine model of GO induced by immunization with a human thyroid-stimulating hormone receptor A-subunit plasmid. Altogether, 52 mice were used: 27 GOs and 25 controls (Ctrl) immunized with β-galactasidose plasmid. From these, 17 GO and 12 Ctrl mice were subjected to multimodal MRI at 9...
January 27, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29373659/simultaneous-aesthetic-eyelid-surgery-and-orbital-decompression-for-rehabilitation-of-thyroid-eye-disease-the-one-stage-approach
#5
Francesco P Bernardini, Brent Skippen, Alessandra Zambelli, Benjamin Riesco, Martin H Devoto
Background: Aesthetic rehabilitation of thyroid orbitopathy includes orbital decompression, correction of eyelid retraction and aesthetic blepharoplasty, performed traditionally in separate stages. Objectives: To report the results of orbital decompression surgery associated with aesthetic eyelid surgery in one stage for aesthetic rehabilitation of patients affected by thyroid eye disease. Methods: Retrospective, multi centric study including 40 consecutive patients, who underwent orbital decompression surgery associated with aesthetic eyelid surgery in two centers: Genova (Group 1) + Buenos Aires (Group 2)...
January 24, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29334744/-selenium-treatment-in-thyreopathies
#6
Štefan Sotak
Selenium (latin Selenium) is a micronutrient embedded in several proteins. In adults, the thyroid is the organ with the highest amount of selenium per gram of tissue. Selenium levels in the body depend on the characteristics of the population and its diet and geographic area. In the thyroid, selenium is required for the antioxidant function and for the metabolism of thyroid hormones. The literature suggests that selenium supplementation of patients with Hashimotos thyroiditis is associated with a reduction in antithyroperoxidase antibody levels...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29332250/the-levels-of-12-cytokines-and-growth-factors-in-tears-hyperthyreosis-vs-euthyreosis
#7
Jelena Juri Mandić, Ana Kozmar, Sanja Kusačić-Kuna, Anamarija Jazbec, Krešimir Mandić, Danijela Mrazovac, Nenad Vukojević
PURPOSE: Simultaneous analyses of the contents and ratios of 12 cytokines and growth factors in single samples of human tears were performed, and the results were compared between a group of healthy subjects and a group of patients with Graves' hyperthyreosis (GH) without thyroid-associated orbitopathy (TAO). METHODS: Determinations and concentration measurements of interleukins (IL-2, IL4, IL-6, IL-8, IL-10, IL-1α, and IL-1β) interferon (IFN-γ), tumor necrosis factor (TNF-α), monocyte chemoattractant protein (MCP-1), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF) were performed with single tear samples from 21 patients with hyperthyreosis and 22 healthy subjects...
January 14, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29330045/thyroid-associated-orbitopathy-when-should-we-operate
#8
REVIEW
Stuart R Seiff, Lilly H Wagner
No abstract text is available yet for this article.
January 9, 2018: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29260102/tocilizumab-as-a-steroid-sparing-agent-for-the-treatment-of-graves-orbitopathy
#9
David J Russell, Lilly H Wagner, Stuart R Seiff
Purpose: To describe the effect of tocilizumab in two patients with thyroid associated orbitopathy (TAO). Observations: We present two patients with TAO who could not tolerate corticosteroids and had a reduction in clinical and laboratory markers of inflammatory activity with subsequent tocilizumab therapy. Conclusions and importance: The IL-6 receptor antibody tocilizumab is a promising candidate for the treatment of TAO because it selectively targets a key inflammatory mediator and has a favorable side effect profile...
September 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29214313/rna-sequencing-gene-expression-profiling-of-orbital-adipose-derived-stem-cell-population-implicate-hox-genes-and-wnt-signaling-dysregulation-in-the-pathogenesis-of-thyroid-associated-orbitopathy
#10
Wensi Tao, Juan A Ayala-Haedo, Matthew G Field, Daniel Pelaez, Sara T Wester
Purpose: The purpose of this study was to characterize the intrinsic cellular properties of orbital adipose-derived stem cells (OASC) from patients with thyroid-associated orbitopathy (TAO) and healthy controls. Methods: Orbital adipose tissue was collected from a total of nine patients: four controls and five patients with TAO. Isolated OASC were characterized with mesenchymal stem cell-specific markers. Orbital adipose-derived stem cells were differentiated into three lineages: chondrocytes, osteocytes, and adipocytes...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29182030/biomarkers-of-ocular-surface-disease-using-impression-cytology
#11
REVIEW
Suzanne Hagan
Impression cytology (IC) is a technique which permits the retrieval of the outermost layer of ocular surface cells via the use of various types of filters. It is a minimally invasive method of evaluating human conjunctival epithelial cell morphology in the diagnosis of dry eye disease, a common and distressing disorder associated with ageing, contact lens wear, autoimmune disorders and refractive (LASIK) surgery. IC may also be utilized in the diagnosis of other ocular diseases, such as keratoconus and thyroid orbitopathy...
December 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29151039/pretibial-myxoedema-without-thyroid-associated-orbitopathy-in-a-patient-with-graves-disease
#12
Sailesh Lodha, Nimisha Jain, Anil Bhansali
No abstract text is available yet for this article.
November 18, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29053503/lenalidomide-associated-thyroid-related-eyelid-retraction
#13
Geraldine R Slean, Rona Z Silkiss
Several antineoplastic treatments have been responsible for thyroid dysfunction and thyroid eye disease. Min, Vaidya, and Becker (2011) reported a case of euthyroid Graves orbitopathy after treatment with ipilimumab with the patient displaying proptosis and myositis in the setting of normal thyroid function tests and elevated thyroid antibodies. The authors report a case of a 76-year-old woman who developed right upper lid retraction and proptosis after 2.5 years of treatment with lenalidomide for multiple myeloma...
October 19, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28935968/electrophysiological-studies-in-thyroid-associated-orbitopathy-a-systematic-review
#14
Tiara W U Iao, Shi Song Rong, An Ni Ling, Mårten E Brelén, Alvin Lerrmann Young, Kelvin K L Chong
Dysthyroid optic neuropathy (DON) is the commonest cause of blindness in thyroid associated orbitopathy (TAO). While diagnosis remains clinical, objective tests for eyes with early or equivocal findings are lacking. Various electrophysiological studies (EPS) have been reported, yet the types and parameters useful for DON remain inconclusive. We performed a systematic literature search in MEDLINE, EMBASE and the Cochrane databases via the OVID platform up to August 20, 2017. 437 records were identified for screening and 16 original studies (1327 eyes, 787 patients) were eligible for review...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28887209/thyroid-associated-orbitopathy-and-tears-a-proteomics-study
#15
Edina Kishazi, Marianne Dor, Simone Eperon, Aurélie Oberic, Mehrad Hamedani, Natacha Turck
To date, Thyroid-Associated Orbitopathy (TAO), an autoimmune inflammatory disease affecting the eye, remains poorly characterised and its diagnosis challenging. The aim of this study was to investigate the tears of the TAO patients in order to identify potential biomarkers. Two independent quantitative Tandem Mass Tag™ 6-plex experiments were done. After in-solution digestion and isoelectric fractionation, the 12 fractions were analysed with a LTQ Orbitrap Velos coupled to a liquid chromatography. Raw files were searched against Swiss-Prot-AC database using Proteome Discoverer software, with a false discovery rate of 1% at peptide and protein levels...
January 6, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/28860913/fat-removal-orbital-decompression-for-thyroid-associated-orbitopathy-the-right-procedure-for-the-right-patient
#16
REVIEW
Eman Al-Sharif, Adel H Alsuhaibani
Orbital decompression is an effective and invaluable procedure for addressing some of the chronic manifestations of Graves' Ophthalmopathy (GO) such as exophthalmos and orbital congestion. Fat-removal orbital decompression (FROD) started to gain popularity after its introduction in the late 20th century. Among the therapeutic armamentarium of techniques and approaches available for orbital decompression, FROD has proven its efficacy and safety in addition to its ability to reduce proptosis in a relatively predictable manner...
July 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28845325/ocular-causes-of-abnormal-head-position-strabismus-clinic-data
#17
Kadriye Erkan Turan, Hande Taylan Şekeroğlu, İrem Koç, Esra Vural, Jale Karakaya, Emin Cumhur Şener, Ali Şefik Sanaç
OBJECTIVES: To determine the most common ocular causes and types of abnormal head position (AHP) and describe their clinical features. MATERIALS AND METHODS: Patients with AHP who had been followed in the strabismus unit were retrospectively reviewed. Demographic features and orthoptic characteristics were recorded. RESULTS: A total of 163 patients including 61 women (37.4%) and 102 men (62.6%), with a mean age of 19.9±18.3 were recruited...
August 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28721111/visual-consequences-of-medications-for-multiple-sclerosis-the-good-the-bad-the-ugly-and-the-unknown
#18
REVIEW
Heather E Moss
Multiple sclerosis (MS) is associated with vision changes both due to MS effects on visual pathways and due to medication effects on the visual pathways. Distinguishing the causes of vision change are critical to appropriate diagnosis and management. The incidence, presentation, and treatment of fingolimod-associated macular edema, alemtuzumab-associated thyroid orbitopathy, and progressive multifocal leukoencephalopathy in MS patients are reviewed. Evidence for beneficial effects of acute, chronic, and symptomatic MS medications on vision is presented...
2017: Eye and Brain
https://www.readbyqxmd.com/read/28500433/the-effect-of-orbital-radiation-therapy-on-thyroid-associated-orbitopathy-complicated-with-dysthyroid-optic-neuropathy
#19
REVIEW
Yang Wang, Huifang Zhou, Xianqun Fan
Thyroid-associated orbitopathy (TAO) is an inflammatory autoimmune disorder. The most serious complication of TAO is dysthyroid optic neuropathy (DON), which can lead to permanent vision loss because of volume expansion in the orbital apex. Orbital radiation therapy (ORT) is an anti-inflammatory treatment used in the treatment of active TAO. Clinical studies support radiotherapy as having a modest effect on DON, and early radiotherapy may protect against disease progression to DON. Current studies suggest that radiotherapy is generally safe...
September 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28439882/prevalence-and-clinical-relevance-of-thyroid-stimulating-hormone-receptor-blocking-antibodies-in-autoimmune-thyroid-disease
#20
T Diana, J Krause, P D Olivo, J König, M Kanitz, B Decallonne, G J Kahaly
The prevalence and clinical relevance of thyroid stimulating hormone (TSH) receptor (TSHR) blocking antibodies (TBAb) in patients with autoimmune thyroid disease (AITD) was investigated. Serum TBAb were measured with a reporter gene bioassay using Chinese hamster ovary cells. Blocking activity was defined as percentage inhibition of luciferase expression relative to induction with bovine TSH alone (cut-off 40% inhibition). All samples were measured for TSHR stimulatory antibody (TSAb) and TSHR binding inhibiting immunoglobulins (TBII)...
September 2017: Clinical and Experimental Immunology
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