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Thyroid associated orbitopathy

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https://www.readbyqxmd.com/read/28935968/electrophysiological-studies-in-thyroid-associated-orbitopathy-a-systematic-review
#1
Tiara W U Iao, Shi Song Rong, An Ni Ling, Mårten E Brelén, Alvin Lerrmann Young, Kelvin K L Chong
Dysthyroid optic neuropathy (DON) is the commonest cause of blindness in thyroid associated orbitopathy (TAO). While diagnosis remains clinical, objective tests for eyes with early or equivocal findings are lacking. Various electrophysiological studies (EPS) have been reported, yet the types and parameters useful for DON remain inconclusive. We performed a systematic literature search in MEDLINE, EMBASE and the Cochrane databases via the OVID platform up to August 20, 2017. 437 records were identified for screening and 16 original studies (1327 eyes, 787 patients) were eligible for review...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28887209/thyroid-associated-orbitopathy-and-tears-a-proteomics-study
#2
Edina Kishazi, Marianne Dor, Simone Eperon, Aurélie Oberic, Mehrad Hamedani, Natacha Turck
To date, Thyroid-Associated Orbitopathy (TAO), an autoimmune inflammatory disease affecting the eye, remains poorly characterised and its diagnosis challenging. The aim of this study was to investigate the tears of the TAO patients in order to identify potential biomarkers. Two independent quantitative Tandem Mass Tag™ 6-plex experiments were done. After in-solution digestion and isoelectric fractionation, the 12 fractions were analysed with a LTQ Orbitrap Velos coupled to a liquid chromatography. Raw files were searched against Swiss-Prot-AC database using Proteome Discoverer software, with a false discovery rate of 1% at peptide and protein levels...
September 5, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28860913/fat-removal-orbital-decompression-for-thyroid-associated-orbitopathy-the-right-procedure-for-the-right-patient
#3
REVIEW
Eman Al-Sharif, Adel H Alsuhaibani
Orbital decompression is an effective and invaluable procedure for addressing some of the chronic manifestations of Graves' Ophthalmopathy (GO) such as exophthalmos and orbital congestion. Fat-removal orbital decompression (FROD) started to gain popularity after its introduction in the late 20th century. Among the therapeutic armamentarium of techniques and approaches available for orbital decompression, FROD has proven its efficacy and safety in addition to its ability to reduce proptosis in a relatively predictable manner...
July 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28845325/ocular-causes-of-abnormal-head-position-strabismus-clinic-data
#4
Kadriye Erkan Turan, Hande Taylan Şekeroğlu, İrem Koç, Esra Vural, Jale Karakaya, Emin Cumhur Şener, Ali Şefik Sanaç
OBJECTIVES: To determine the most common ocular causes and types of abnormal head position (AHP) and describe their clinical features. MATERIALS AND METHODS: Patients with AHP who had been followed in the strabismus unit were retrospectively reviewed. Demographic features and orthoptic characteristics were recorded. RESULTS: A total of 163 patients including 61 women (37.4%) and 102 men (62.6%), with a mean age of 19.9±18.3 were recruited...
August 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28721111/visual-consequences-of-medications-for-multiple-sclerosis-the-good-the-bad-the-ugly-and-the-unknown
#5
REVIEW
Heather E Moss
Multiple sclerosis (MS) is associated with vision changes both due to MS effects on visual pathways and due to medication effects on the visual pathways. Distinguishing the causes of vision change are critical to appropriate diagnosis and management. The incidence, presentation, and treatment of fingolimod-associated macular edema, alemtuzumab-associated thyroid orbitopathy, and progressive multifocal leukoencephalopathy in MS patients are reviewed. Evidence for beneficial effects of acute, chronic, and symptomatic MS medications on vision is presented...
2017: Eye and Brain
https://www.readbyqxmd.com/read/28500433/the-effect-of-orbital-radiation-therapy-on-thyroid-associated-orbitopathy-complicated-with-dysthyroid-optic-neuropathy
#6
REVIEW
Yang Wang, Huifang Zhou, Xianqun Fan
Thyroid-associated orbitopathy (TAO) is an inflammatory autoimmune disorder. The most serious complication of TAO is dysthyroid optic neuropathy (DON), which can lead to permanent vision loss because of volume expansion in the orbital apex. Orbital radiation therapy (ORT) is an anti-inflammatory treatment used in the treatment of active TAO. Clinical studies support radiotherapy as having a modest effect on DON, and early radiotherapy may protect against disease progression to DON. Current studies suggest that radiotherapy is generally safe...
September 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28439882/prevalence-and-clinical-relevance-of-thyroid-stimulating-hormone-receptor-blocking-antibodies-in-autoimmune-thyroid-disease
#7
T Diana, J Krause, P D Olivo, J König, M Kanitz, B Decallonne, G J Kahaly
The prevalence and clinical relevance of thyroid stimulating hormone (TSH) receptor (TSHR) blocking antibodies (TBAb) in patients with autoimmune thyroid disease (AITD) was investigated. Serum TBAb were measured with a reporter gene bioassay using Chinese hamster ovary cells. Blocking activity was defined as percentage inhibition of luciferase expression relative to induction with bovine TSH alone (cut-off 40% inhibition). All samples were measured for TSHR stimulatory antibody (TSAb) and TSHR binding inhibiting immunoglobulins (TBII)...
September 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28356724/evaluation-of-the-association-between-subconjunctival-orbital-fat-prolapse-and-thyroid-associated-orbitopathy
#8
COMMENT
Sang Beom Han
No abstract text is available yet for this article.
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28336282/-management-of-upper-eyelid-retraction-associated-with-dysthyroid-orbitopathy-during-the-acute-inflammatory-phase-with-botulinum-toxin-type-a
#9
COMPARATIVE STUDY
A Nava Castañeda, J L Tovilla Canales, L Garnica Hayashi, A Velasco Y Levy
PURPOSE: To evaluate the efficacy of transconjunctival botulinum toxin type A (BTX-A) in the treatment of upper eyelid retraction in the active inflammatory phase of dysthyroid orbitopathy, establish the ideal dose, and evaluate side effects. METHODS: This is a comparative, prospective study in patients with thyroid orbitopathy, conducted at the Conde Ophthalmology Institute in Valenciana, Mexico. The patients included had dysthyroid orbitopathy in the inflammatory phase, and they were treated with subconjunctival injection of botulinum toxin type A (BTX-A) in the upper eyelid...
April 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28329891/treatment-of-extreme-strabismus-in-tao-thyroid-associated-orbitopathy-medial-rectus-and-inferior-rectus-tendon-elongation-as-an-alternative-to-conventional-strabismus-surgery-a-case-report
#10
M Wipf, A Palmowski-Wolfe
No abstract text is available yet for this article.
April 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28255299/selenium-and-thyroid-disease-from-pathophysiology-to-treatment
#11
REVIEW
Mara Ventura, Miguel Melo, Francisco Carrilho
Introduction. Selenium is a micronutrient embedded in several proteins. In adults, the thyroid is the organ with the highest amount of selenium per gram of tissue. Selenium levels in the body depend on the characteristics of the population and its diet, geographic area, and soil composition. In the thyroid, selenium is required for the antioxidant function and for the metabolism of thyroid hormones. Methods. We performed a review of the literature on selenium's role in thyroid function using PubMed/MEDLINE...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28243072/subconjunctival-orbital-fat-prolapse-and-thyroid-associated-orbitopathy-a-clinical-association
#12
Klio I Chatzistefanou, Christianna Samara, Ioannis Asproudis, Dimitrios Brouzas, Marilita M Moschos, Elisabeth Tsianta, George Piaditis
BACKGROUND: Thyroid associated orbitopathy (TAO) comprises a spectrum of well-recognized clinical signs including exophthalmos, eyelid retraction, soft tissue swelling, ocular misalignment, keratopathy as well as a number of less common manifestations. Subconjunctival fat prolapse is a rare clinical condition occurring typically spontaneously in elderly patients with a mean age of 65-72 years. We describe subconjunctival prolapse of orbital fat as an uncommon clinical association of TAO...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28130596/the-effect-of-orbital-decompression-surgery-on-interpupillary-distance-and-angle-kappa-in-patients-with-thyroid-associated-orbitopathy
#13
Joon Hyung Yeo, Sang Joon Park, Yeon Sook Chun, Jee Taek Kim, Nam Ju Moon, Jeong Kyu Lee
PURPOSE: The purpose was to investigate the effects of orbital decompression surgery on postoperative changes in interpupillary distance (IPD) and angle kappa in patients with thyroid-associated orbitopathy (TAO). METHODS: In patients with TAO who underwent orbital decompression surgery between January 1, 2014 and February 21, 2016, we measured exopthalmometry, IPD, inner intercanthal distance (IICD) and outer intercanthal distance (OICD) using a computer software program and angle kappa with an ORB scan II...
April 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28078992/smoking-and-eye-pathologies-a-systemic-review-part-ii-retina-diseases-uveitis-optic-neuropathies-thyroid-associated-orbitopathy
#14
Małgorzata Nita, Andrzej Grzybowski
BACKGROUND: Tobacco smoking has detrimental influence on human health. AIM: The analysis of influence of tobacco smoking on retina diseases, uveitis, optic neuropathies, and thyroidassociated orbitopathy in adults and children. METHODS: A comprehensive review of the literature performed through MEDLINE and PubMed searches, covering the years 2000-2016. RESULTS: In adults, tobacco smoking is a strong risk factor for age-related macular degeneration, polypoidal choroidal vasculopathy, uveitis and inflamed cystoid macular edema as well as Grave`s ophthalmopathy...
2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28076605/isolated-primary-amyloidosis-of-the-inferior-rectus-muscle-mimicking-graves-orbitopathy
#15
Mário Luiz Ribeiro Monteiro, Allan Christian Pieroni Gonçalves, Alanna Mara Pinheiro Sobreira Bezerra
The diagnosis of Graves' orbitopathy is usually straightforward. However, orbital diseases that mimick some clinical signs of Graves' orbitopathy may cause diagnostic confusion, particularly when associated to some form of thyroid dysfunction. This report describes the rare occurrence of localized inferior rectus muscle amyloidosis in a patient with autoimmune hypothyroidism, who was misdiagnosed as Graves' orbitopathy. A 48-year-old man complained of painless progressive proptosis on the left side and intermittent vertical diplopia for 6 months...
October 2016: Einstein
https://www.readbyqxmd.com/read/27990368/evaluation-of-retinal-nerve-fiber-layer-thickness-profile-in-thyroid-ophthalmopathy-without-optic-nerve-dysfunction
#16
Kumari Mugdha, Apjit Kaur, Neha Sinha, Sandeep Saxena
AIM: To evaluate retinal nerve fiber layer (RNFL) thickness profile in patients of thyroid ophthalmopathy with no clinical signs of optic nerve dysfunction. METHODS: A prospective, case-control, observational study conducted at a tertiary care centre. Inclusion criteria consisted of patients with eyelid retraction in association with any one of: biochemical thyroid dysfunction, exophthalmos, or extraocular muscle involvement; or thyroid dysfunction in association with either exophthalmos or extra-ocular muscle involvement; or a clinical activity score (CAS)>3/7...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27967219/a-survey-of-clinical-practice-patterns-in-management-of-graves-disease-in-the-middle-east-and-north-africa
#17
Salem A Beshyah, Aly B Khalil, Ibrahim H Sherif, Mahmoud M Benbarka, Syed Abbas Raza, Wiam Hussein, Ali S Alzahrani, Asma Chadli
OBJECTIVE: Graves disease (GD) is commonly seen in endocrine clinical practice. The objective of this study was to evaluate the current diagnosis and management of patients with GD in the Middle East and North Africa (MENA). METHODS: An electronic survey on GD management was performed using an online questionnaire of a large pool of practicing physicians. Responses from 352 eligible and willing physicians were included in this study. They were mostly endocrinologists (157) and internal medicine physicians (116)...
March 2017: Endocrine Practice
https://www.readbyqxmd.com/read/27902601/time-course-of-graves-orbitopathy-after-total-thyroidectomy-and-radioiodine-therapy-for-thyroid-cancer
#18
MULTICENTER STUDY
Camille Louvet, Annamaria De Bellis, Bruno Pereira, Claire Bournaud, Antony Kelly, Salwan Maqdasy, Beatrice Roche, Francoise Desbiez, Francoise Borson-Chazot, Igor Tauveron, Marie Batisse-Lignier
The risk of cancer is relatively higher in Graves' patients presenting simultaneously with thyroid nodules. Radioiodine (RAI) therapy recommended in high-risk differentiated thyroid carcinoma may be associated with worsening of a pre-existing Graves' orbitopathy (GO) or developing a new onset. The impact of RAI therapy in patients with differentiated thyroid cancer on the course of a pre-exisiting GO has not been specifically investigated.The aim of this study is to assess the influence of RAI treatment administered for differentiated thyroid cancer on the course of a pre-existing GO...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27844093/fractional-anisotropy-and-diffusivity-changes-in-thyroid-associated-orbitopathy
#19
Ji Sung Han, Hyung Suk Seo, Young Hen Lee, Hwa Lee, Sang-Il Suh, Eun-Kee Jeong, Nabraj Sapkota, Ki Joon Kim
INTRODUCTION: To investigate the extraocular muscle (EOM) changes in thyroid-associated orbitopathy (TAO) on DTI and the correlations between DTI parameters and clinical features. METHODS: Twenty TAO patients and 20 age- and sex-matched controls provided informed consent and were enrolled. Ten-directional DTI was acquired in orbit. Fractional anisotropy (FA), mean, axial, and radial diffusivities were obtained at medial and lateral EOMs in both orbits. EOM thickness was measured in patients using axial CT images...
December 2016: Neuroradiology
https://www.readbyqxmd.com/read/27843806/a-2016-italian-survey-about-the-clinical-use-of-selenium-in-thyroid-disease
#20
Roberto Negro, Roberto Attanasio, Franco Grimaldi, Claudio Marcocci, Rinaldo Guglielmi, Enrico Papini
BACKGROUND: Selenium (Se) is a trace element that plays key roles in thyroid physiology. Se deficiency is associated with increased risk of thyroid disease. Some evidence suggests that Se supplementation may be beneficial in autoimmune thyroid disease (either hypo- or hyperthyroidism). OBJECTIVES: We sought to examine the use of Se in daily clinical practice among Italian endocrinologists. METHODS: Members of the Associazione Medici Endocrinologi (AME) were invited to participate in a web-based survey investigating the use of Se in different clinical conditions...
September 2016: European Thyroid Journal
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