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Thyroid associated orbitopathy

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https://www.readbyqxmd.com/read/27902601/time-course-of-graves-orbitopathy-after-total-thyroidectomy-and-radioiodine-therapy-for-thyroid-cancer
#1
Camille Louvet, Annamaria De Bellis, Bruno Pereira, Claire Bournaud, Antony Kelly, Salwan Maqdasy, Beatrice Roche, Francoise Desbiez, Francoise Borson-Chazot, Igor Tauveron, Marie Batisse-Lignier
The risk of cancer is relatively higher in Graves' patients presenting simultaneously with thyroid nodules. Radioiodine (RAI) therapy recommended in high-risk differentiated thyroid carcinoma may be associated with worsening of a pre-existing Graves' orbitopathy (GO) or developing a new onset. The impact of RAI therapy in patients with differentiated thyroid cancer on the course of a pre-exisiting GO has not been specifically investigated.The aim of this study is to assess the influence of RAI treatment administered for differentiated thyroid cancer on the course of a pre-existing GO...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27844093/fractional-anisotropy-and-diffusivity-changes-in-thyroid-associated-orbitopathy
#2
Ji Sung Han, Hyung Suk Seo, Young Hen Lee, Hwa Lee, Sang-Il Suh, Eun-Kee Jeong, Nabraj Sapkota, Ki Joon Kim
INTRODUCTION: To investigate the extraocular muscle (EOM) changes in thyroid-associated orbitopathy (TAO) on DTI and the correlations between DTI parameters and clinical features. METHODS: Twenty TAO patients and 20 age- and sex-matched controls provided informed consent and were enrolled. Ten-directional DTI was acquired in orbit. Fractional anisotropy (FA), mean, axial, and radial diffusivities were obtained at medial and lateral EOMs in both orbits. EOM thickness was measured in patients using axial CT images...
November 14, 2016: Neuroradiology
https://www.readbyqxmd.com/read/27843806/a-2016-italian-survey-about-the-clinical-use-of-selenium-in-thyroid-disease
#3
Roberto Negro, Roberto Attanasio, Franco Grimaldi, Claudio Marcocci, Rinaldo Guglielmi, Enrico Papini
BACKGROUND: Selenium (Se) is a trace element that plays key roles in thyroid physiology. Se deficiency is associated with increased risk of thyroid disease. Some evidence suggests that Se supplementation may be beneficial in autoimmune thyroid disease (either hypo- or hyperthyroidism). OBJECTIVES: We sought to examine the use of Se in daily clinical practice among Italian endocrinologists. METHODS: Members of the Associazione Medici Endocrinologi (AME) were invited to participate in a web-based survey investigating the use of Se in different clinical conditions...
September 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27828690/immunoglobulin-g4-related-thyroid-disorders-diagnostic-challenges-and-clinical-outcomes
#4
Deep Dutta, Arvind Ahuja, Chitra Selvan
Ig-G4 related disease (IgG4RD) is a heterogeneous disorder with multi-organ involvement recognised as a separate entity at the start of this century only. It is currently one of the hottest areas of clinical and translational research across specialties. Thyroid involvement in IgG4RD is rare, believed to occur in less than 4% of cases, may be isolated or may be associated with other organ involvement. As of today Riedel's thyroiditis, fibrosing variant of Hashimoto's thyroiditis, and few patients of Graves' orbitopathy represent the types of IgG4-related thyroid disease (IgG4RTD)...
2016: Endokrynologia Polska
https://www.readbyqxmd.com/read/27780830/can-we-predict-relapse-in-graves-disease-results-from-a-systematic-review-and-meta-analysis
#5
Tristan Struja, Hannah Fehlberg, Alexander Kutz, Larissa Guebelin, Christian Degen, Beat Muller, Philipp Schuetz
BACKGROUND: Identification of pre-treatment risk factors predicting relapse in patients with hyperthyroidism of Graves' disease after stopping anti-thyroid drugs [ATD] is decisive to guide therapeutic options. PURPOSE: We performed a systematic search and meta-analysis to study predictors for relapse after stopping ATD in patients with Graves' disease. METHODS: Based on a pre-specified protocol, we searched PubMed, EMBASE and Cochrane in July 2015 for case-control, controlled, and randomized-controlled trials reporting risk factors for relapse after stopping ATD...
October 25, 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27732097/variables-affecting-the-long-term-outcome-of-graves-orbitopathy-following-high-dose-intravenous-glucocorticoid-pulse-therapy-in-patients-not-treated-with-orbital-radiotherapy
#6
Marenza Leo, Teresa Mautone, Ilaria Ionni, Maria Antonietta Profilo, Elena Sabini, Francesca Menconi, Barbara Mazzi, Roberto Rocchi, Francesco Latrofa, Marco Nardi, Paolo Vitti, Claudio Marcocci, Michele Marinò
OBJECTIVE: Intravenous (iv) glucocorticoids (GC) (ivGC) are used for active Graves orbitopathy (GO), but factors affecting GO outcome are poorly understood. We performed a retrospective study to investigate the variables affecting GO after ivGC. METHODS: We evaluated 83 consecutive GO patients treated with ivGC but not orbital radiotherapy (ORT) and re-examined them after a median of 47 months. The endpoints were the relationships between GO outcome or additional treatments with age, sex, smoking habits, thyroid volume, thyroid treatment, time since thyroid treatment, antithyroid-stimulating hormone receptor antibodies (TRAb), GO duration, GO features, and follow-up time...
October 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27706674/immunological-impression-cytology-of-the-conjunctival-epithelium-in-patients-with-thyroid-orbitopathy-related-dry-eye
#7
S L Hsu, P Y Lee, C H Chang, C H Chen
Thyroid orbitopathy (TO) is an autoimmune disease that is complicated by ocular surface disorders, leading to discomfort. Dry eye is very prevalent in patients with TO. Recent studies on the pathogenesis of dry eye have focused on the inflammatory process, and some supporting evidence has been discovered. Because TO is a disorder of autoimmune origin, we assumed that the association between TO and dry eye is related to inflammation. Inflammation of the ocular surface in TO-related dry eye has not been well studied...
August 30, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27682712/an-update-on-thyroid-associated-ophthalmopathy-in-children-and-adolescents
#8
Justyna Szczapa-Jagustyn, Anna Gotz-Więckowska, Jarosław Kocięcki
BACKGROUND: Risk of developing thyroid-associated ophthalmopathy (TAO) in children and adolescents is similar or may be even slightly higher than in adults. The aim of this article is to review and summarize current knowledge regarding diagnostic and therapeutic measures in pediatric TAO. CONTENT: MEDLINE and EMBASE papers were searched using the terms 'pediatric Graves' ophthalmopathy' 'pediatric Graves' orbitopathy', 'thyroid-associated ophthalmopathy in childhood and adolescence' from the year 1970 to December 2015...
October 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27534827/efficacy-and-safety-of-radioiodine-therapy-for-mild-graves-ophthalmopathy-in-dependence-on-cigarette-consumption-a-half-year-of-follow-up
#9
Agata Czarnywojtek, Krzesisława Komar-Rychlicka, Małgorzata Zgorzalewicz-Stachowiak, Nadia Sawicka-Gutaj, Kosma Woliński, Paweł Gut, Maria Płazinska, Barbara Torlińska, Ewa Florek, Joanna Waligórska-Stachura, Marek Ruchała
INTRODUCTION    Graves' Orbitopathy (GO) is an autoimmune disease associated with Graves' disease. Therapy is largely dependent on the severity and activity of ocular changes. Particular attention should be given to radioiodine therapy (RIT). Although its application is a valuable method of the treatment of hyperthyroidism, it may be followed by worsening of GO. OBJECTIVES    The aim of the present article is to indicate how the severity of nicotine addiction influences the response for RAI treatment in GO patients...
August 18, 2016: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/27521067/2016-american-thyroid-association-guidelines-for-diagnosis-and-management-of-hyperthyroidism-and-other-causes-of-thyrotoxicosis
#10
Douglas S Ross, Henry B Burch, David S Cooper, M Carol Greenlee, Peter Laurberg, Ana Luiza Maia, Scott A Rivkees, Mary Samuels, Julie Ann Sosa, Marius N Stan, Martin A Walter
BACKGROUND: Thyrotoxicosis has multiple etiologies, manifestations, and potential therapies. Appropriate treatment requires an accurate diagnosis and is influenced by coexisting medical conditions and patient preference. This document describes evidence-based clinical guidelines for the management of thyrotoxicosis that would be useful to generalist and subspecialty physicians and others providing care for patients with this condition. METHODS: The American Thyroid Association (ATA) previously cosponsored guidelines for the management of thyrotoxicosis that were published in 2011...
October 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27465670/the-phenotype-of-newly-diagnosed-graves-disease-in-italy-in-recent-years-is-milder-than-in-the-past-results-of-a-large-observational-longitudinal-study
#11
L Bartalena, E Masiello, F Magri, G Veronesi, E Bianconi, F Zerbini, M Gaiti, E Spreafico, D Gallo, P Premoli, E Piantanida, M L Tanda, M Ferrario, P Vitti, L Chiovato
OBJECTIVE: The Merseburg triad (hyperthyroidism, goiter, and orbitopathy) characterizes classical description of Graves' disease (GD). Aim of this observational, longitudinal study was to evaluate the current clinical features of newly diagnosed GD in Italy. MATERIALS AND METHODS: In two Northern Italy centers (Varese and Pavia), 283 consecutive patients (211 women, 72 men; mean age 47.4 years) with newly diagnosed GD were recruited in the years 2010-2014. Diagnosis was based on established criteria, and thyroid volume was assessed by ultrasonography...
December 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27365323/orbital-fat-volumetry-and-water-fraction-measurements-using-t2-weighted-fse-ideal-imaging-in-patients-with-thyroid-associated-orbitopathy
#12
Y Kaichi, K Tanitame, H Itakura, H Ohno, M Yoneda, Y Takahashi, Y Akiyama, K Awai
BACKGROUND AND PURPOSE: The quantitative evaluation of orbital fat proliferation and edema and the assessment of extraocular muscles are useful for diagnosing and monitoring thyroid-associated orbitopathy. To evaluate therapy-induced quantitative changes in the orbital fat of patients with thyroid-associated orbitopathy, we performed volumetric and water fraction measurements by using T2-weighted FSE iterative decomposition of water and fat with echo asymmetry and least-squares estimation (FSE-IDEAL) imaging...
June 30, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27359290/variables-affecting-the-long-term-outcome-of-graves-orbitopathy-following-high-dose-intravenous-glucocorticoid-pulse-therapy-in-patients-not-treated-with-orbital-radiotherapy
#13
Marenza Leo, Teresa Mautone, Ilaria Ionni, Maria Antonietta Profilo, Elena Sabini, Francesca Menconi, Barbara Mazzi, Roberto Rocchi, Francesco Latrofa, Marco Nardi, Paolo Vitti, Claudio Marcocci, Michele Marinò
Objective Intravenous (iv) glucocorticoids (GC) (ivGC) are used for active Graves' orbitopathy (GO), but factors affecting GO outcome are poorly known. Here we performed a retrospective study aimed at investigating the variables affecting GO after ivGC. Methods We evaluated 83 consecutive GO patients treated with ivGC, but not with orbital radiotherapy, and re-examined them after a median period of 47 months. The end-points were the relation between GO outcome or additional treatments with age, gender, smoking, thyroid volume, thyroid treatment, time since thyroid treatment, TRAb, GO duration, GO features and follow-up time...
June 30, 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27304844/association-of-polymorphisms-in-macro-domain-containing-2-with-thyroid-associated-orbitopathy
#14
Jwu Jin Khong, Kathryn P Burdon, Yi Lu, Lefta Leonardos, Kate J Laurie, John P Walsh, Adam D Gajdatsy, Peter R Ebeling, Alan A McNab, Thomas G Hardy, Richard J Stawell, Garry J Davis, Dinesh Selva, Angelo Tsirbas, Grant W Montgomery, Stuart Macgregor, Jamie E Craig
PURPOSE: Thyroid-associated orbitopathy (TO) is an autoimmune-mediated orbital inflammation that can lead to disfigurement and blindness. Multiple genetic loci have been associated with Graves' disease, but the genetic basis for TO is largely unknown. This study aimed to identify loci associated with TO in individuals with Graves' disease, using a genome-wide association scan (GWAS) for the first time to our knowledge in TO. METHODS: Genome-wide association scan was performed on pooled DNA from an Australian Caucasian discovery cohort of 265 participants with Graves' disease and TO (cases) and 147 patients with Graves' disease without TO (controls)...
June 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27255721/letter-to-the-editor-comment-on-thyroid-stimulating-antibodies-are-highly-prevalent-in-hashimoto-thyroiditis-and-associated-orbitopathy-dear-editor
#15
Mustafa Sahin, Rifat Emral
No abstract text is available yet for this article.
June 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27158617/corneal-biomechanical-changes-and-intraocular-pressure-in-patients-with-thyroid-orbitopathy
#16
Zofia Pniakowska, Anna Klysik, Roman Gos, Piotr Jurowski
AIM: To determine the relevance of the objective parameters addressing the altered biomechanical properties of cornea for glaucoma monitoring in patients with mild or moderate thyroid associated orbitopathy (TAO), and in healthy individuals. METHODS: Twenty-five patients with TAO (group 1) and 25 healthy adults (group 2) were included to the study. Both groups were of a similar age and the ratio women:man. For each patient, the following parameters of both eyes were measured with ocular response analyzer (ORA): corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann correlated intraocular pressure (IOPg) and corneal compensated intraocular pressure (IOPcc)...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27136135/ocular-and-orbital-side-effects-of-checkpoint-inhibitors-a-review-article
#17
Joëlle Antoun, Cherif Titah, Isabelle Cochereau
PURPOSE OF REVIEW: Checkpoint inhibitors have been increasingly considered as new targets for cancer therapies. Patients receiving checkpoint inhibitors develop many immune-related adverse events (IRAEs). However, ophthalmic IRAEs are rare and have been reported in less than 1% of patients. To date, few case reports evaluating the ophthalmological side-effects of checkpoint inhibitors have been published. In this review, we plan to report the different ocular and orbital side-effects of the checkpoint inhibitors, and to help guide ophthalmologists and oncologists in their management...
July 2016: Current Opinion in Oncology
https://www.readbyqxmd.com/read/27099835/the-2016-european-thyroid-association-european-group-on-graves-orbitopathy-guidelines-for-the-management-of-graves-orbitopathy
#18
Luigi Bartalena, Lelio Baldeschi, Kostas Boboridis, Anja Eckstein, George J Kahaly, Claudio Marcocci, Petros Perros, Mario Salvi, Wilmar M Wiersinga
Graves' orbitopathy (GO) is the main extrathyroidal manifestation of Graves' disease, though severe forms are rare. Management of GO is often suboptimal, largely because available treatments do not target pathogenic mechanisms of the disease. Treatment should rely on a thorough assessment of the activity and severity of GO and its impact on the patient's quality of life. Local measures (artificial tears, ointments and dark glasses) and control of risk factors for progression (smoking and thyroid dysfunction) are recommended for all patients...
March 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27090092/the-natural-history-of-subclinical-hyperthyroidism-in-graves-disease-the-rule-of-thirds
#19
Sviatlana Zhyzhneuskaya, Caroline Addison, Vasileios Tsatlidis, Jolanta U Weaver, Salman Razvi
BACKGROUND: There is little information regarding the natural history of subclinical hyperthyroidism (SH) due to Graves' disease (GD). METHODS: A prospective analysis was conducted of patients with SH due to GD between 2007 and 2013 with at least 12 months of follow-up. SH was diagnosed if serum thyrotropin (TSH) was below the laboratory reference range (0.4-4.0 mIU/L) and when thyroid hormones were normal. GD was confirmed by either a raised TSH receptor antibody (TRAb) level or uniform uptake on Technetium scan...
June 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27079592/botulinum-toxin-injection-for-restrictive-myopathy-of-thyroid-associated-orbitopathy-success-rate-and-predictive-factors
#20
Mohammad Reza Akbari, Ahmad Ameri, Ali Reza Keshtkar Jaafari, Arash Mirmohammadsadeghi
PURPOSE: To evaluate the rate of and predictive factors for successful treatment of restrictive myopathy in thyroid-associated orbitopathy (TAO) using botulinum toxin injection. METHODS: Twenty patients with restrictive myopathy of TAO were enrolled in the study. Abnormal thyroid function test results were not a prerequisite for inclusion. In each extraocular muscle 25 units of botulinum toxinA were injected. The success rate, calculated at 2 years or last follow-up before surgery, was defined as proportion of the cases with esotropia of <10(Δ), vertical deviation of <5(Δ), and no diplopia in primary position and downgaze for at least 1 year...
April 2016: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
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