Jun Lin, Xiaoxiao Jiang, Meng Dong, Xiaomeng Liu, Qiwei Shen, Yuanyuan Huang, Hanlin Zhang, Rongcai Ye, Huiqiao Zhou, Chunlong Yan, Shouli Yuan, Xiangnan Wu, Li Chen, Yanfang Wang, Min He, Yi Tao, Zhaoyun Zhang, Wanzhu Jin
Intermittent fasting (IF), as a dietary intervention for weight loss, takes effects primarily through increasing energy expenditure. However, whether inter-organ systems play a key role in IF remains unclear. Here, a novel hepatokine, pregnancy zone protein (PZP) is identified, which has significant induction during the refeeding stage of IF. Further, loss of function studies and protein therapeutic experiment in mice revealed that PZP promotes diet-induced thermogenesis through activating brown adipose tissue (BAT)...
September 13, 2021: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)