Bao Kong, Chae Young Han, Se Ik Kim, David A Patten, Youngjin Han, Euridice Carmona, Dar-Bin Shieh, Annie C Cheung, Anne-Marie Mes-Masson, Mary-Ellen Harper, Yong Sang Song, Benjamin K Tsang
BACKGROUND: Mitochondrial dynamics (e.g. fission/fusion) play an important role in controlling chemoresistance in representative gynecologic malignancies, ovarian and cervical cancer. Processing the long form of Optic atrophy (L-Opa)1 is a distinctive character of mitochondrial fragmentation, associated with chemosensitivity. Here, we examined the role of prohibitin (Phb)1 in increasing L-Opa1 processing via the regulating mitochondrial protease, Oma1 and its direct interaction with p-p53 (ser15) and pro-apoptotic Bcl-2 antagonist/killer (Bak) 1 in the signaling axis and if this phenomenon is associated with prognosis of patients...
June 7, 2022: Journal of Ovarian Research