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https://www.readbyqxmd.com/read/28076766/are-gut-microbes-responsible-for-post-dieting-weight-rebound
#1
Julien Chilloux, Marc-Emmanuel Dumas
One of the dieting conundrums in the age of the obesity epidemic is the cycle of weight loss and regain known as the "yo-yo effect." Thaiss et al. (2016) demonstrate that the microbiome plays a key role in this phenomenon and that simple dietary supplementations can reset the weight-rebound clock.
January 10, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28073288/pattern-versus-change
#2
Harleah G Buck, Judith Hupcey, Alexa Watach
It is imperative that dyadic heart failure (HF) self-care be carefully examined so we can develop interventions which improve patient outcomes. The purpose of this study was to qualitatively examine how patient/informal caregiver dyads mutually engage in managing the patient's HF at home. Twenty-seven dyads were interviewed using a theoretically derived interview guide. All interviews were digitally recorded and professionally transcribed, and iterative thematic analysis was conducted. Three descriptive themes emerged-Mutual engagement in self-care involves maintaining established patterns of engagement across the life course of the relationship, changing patterns according to whether it is day-to-day care or symptom management, and mobilizing the help of a third party as consultant...
January 1, 2017: Clinical Nursing Research
https://www.readbyqxmd.com/read/28072627/an-unsolved-conundrum-right-ventricular-dysfunction
#3
Pierfranco Terrosu
No abstract text is available yet for this article.
January 7, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28070561/the-discovery-of-a-conjugate-system-of-faults-in-the-wharton-basin-intraplate-deformation-zone
#4
Satish C Singh, Nugroho Hananto, Yanfang Qin, Frederique Leclerc, Praditya Avianto, Paul E Tapponnier, Helene Carton, Shengji Wei, Adam B Nugroho, Wishnu A Gemilang, Kerry Sieh, Sylvain Barbot
The deformation at well-defined, narrow plate boundaries depends on the relative plate motion, but how the deformation takes place within a distributed plate boundary zone remains a conundrum. This was confirmed by the seismological analyses of the 2012 great Wharton Basin earthquakes [moment magnitude (Mw) 8.6], which suggested the rupture of several faults at high angles to one another. Using high-resolution bathymetry and seismic reflection data, we report the discovery of new N294°E-striking shear zones, oblique to the plate fabric...
January 2017: Science Advances
https://www.readbyqxmd.com/read/28065662/hot-heads-cool-bodies-the-conundrums-of-human-bat-activity-research
#5
REVIEW
Lonneke Bahler, Frits Holleman, Jan Booij, Joost B Hoekstra, Hein J Verberne
Brown adipose tissue is able to increase energy expenditure by converting glucose and fatty acids into heat. Therefore, BAT is able to increase energy expenditure and could thereby facilitate weight loss or at least weight maintenance. Since cold is a strong activator of BAT, most prospective research is performed during cold to activate BAT. In current research, there are roughly two methods of cooling. Cooling by lowering ambient air temperature, which uses a fixed temperature for all subjects and personalized cooling, which uses cooling blankets or vests with temperatures that can be adjusted to the individual set point of shivering...
January 5, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28059729/a-conundrum-for-density-functional-theory
#6
Sharon Hammes-Schiffer
No abstract text is available yet for this article.
January 6, 2017: Science
https://www.readbyqxmd.com/read/28058619/cyber-attacks-and-terrorism-a-twenty-first-century-conundrum
#7
Marwan Albahar
In the recent years, an alarming rise in the incidence of cyber attacks has made cyber security a major concern for nations across the globe. Given the current volatile socio-political environment and the massive increase in the incidence of terrorism, it is imperative that government agencies rapidly realize the possibility of cyber space exploitation by terrorist organizations and state players to disrupt the normal way of life. The threat level of cyber terrorism has never been as high as it is today, and this has created a lot of insecurity and fear...
January 5, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28058081/fungal-esophagitis-presenting-with-esophagitis-dissecans-superficialis-cause-or-concurrence-a-diagnostic-conundrum
#8
Rashmee Patil, Tagore Sunkara, Mel A Ona, Vinaya Gaduputi, Madhavi Reddy
Esophagitis dissecans superficialis (EDS) is a rare desquamative disorder of the esophagus. It is characterized by sheets of sloughed squamous tissue with normal underlying mucosa. We present a case of a 68-year-old man with severe anemia and a positive fecal occult blood test who was found to have features suggestive of EDS during endoscopy. However, histological features were suggestive of both EDS and fungal esophagitis. To our knowledge, this is the first reported case in literature which discusses the clinical scenario of fungal infection being a possible etiology rather than a commonly accepted differential diagnosis of EDS...
December 2016: Gastroenterology Research
https://www.readbyqxmd.com/read/28046970/su-g-brc-05-conundrum-for-vmat-cranial-multiple-lesions-treated-with-hd120-mlc
#9
S Lim, L Kuo, L Happersett, D Lovelock, A Ballangrud, T LoSasso
PURPOSE: To commission a custom 6MV-SRS-AAA Eclipse beam model for VMAT multiple lesions cranial SRS treatment on a Varian TrueBeam STx. METHODS: Six clinical plans were created using a customized beam model with dosimetric-leaf-gap(DLG) optimized for clinical treatments. Each plan had 4-6 non-isocentric targets with size from 0.2 to 7.1cc. All fields were measured with EBT3 film in the coronal plane in a solid water phantom and with an AS1000 EPID using gantry rotation...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28044203/advances-with-neonatal-aerodigestive-science-in-the-pursuit-of-safe-swallowing-in-infants-invited-review
#10
Sudarshan R Jadcherla
Feeding, swallowing, and airway protection are three distinct entities. Feeding involves a process of sequential, neurosensory, and neuromotor interactions of reflexes and behaviors facilitating ingestion. Swallowing involves anterograde bolus movement during oral-, pharyngeal-, and esophageal phases of peristalsis into stomach. During these events, coordination with airway protection is vital for homeostasis in clearing any material away from airway vicinity. Neurological-airway-digestive inter-relationships are critical to the continuum of successful feeding patterns during infancy, either in health or disease...
January 2, 2017: Dysphagia
https://www.readbyqxmd.com/read/28043453/mechanical-vs-biologic-valves-our-modern-day-conundrum
#11
Thoralf M Sundt, Hartzell V Schaff, Edward G Soltesz, Miguel Sousa Uva, David H Adams
No abstract text is available yet for this article.
July 2016: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28035533/mitochondrial-cholesterol-and-the-paradox-in-cell-death
#12
Carmen García-Ruiz, Vicente Ribas, Anna Baulies, Jose C Fernández-Checa
Mitochondria are considered cholesterol-poor organelles, and obtain their cholesterol load by the action of specialized proteins involved in its delivery from extramitochondrial sources and trafficking within mitochondrial membranes. Although mitochondrial cholesterol fulfills vital physiological functions, such as the synthesis of bile acids in the liver or the formation of steroid hormones in specialized tissues, recent evidence indicates that the accumulation of cholesterol in mitochondria may be a key event in prevalent human diseases, in particular in the development of steatohepatitis (SH) and its progression to hepatocellular carcinoma (HCC)...
December 30, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28018526/the-burnout-conundrum-nature-versus-nurture
#13
EDITORIAL
Gail M Sullivan
No abstract text is available yet for this article.
December 2016: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/28001006/intracameral-antibiotic-the-vancomycin-conundrum
#14
EDITORIAL
Chandra Bala
No abstract text is available yet for this article.
December 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28000554/a-homodimer-model-can-resolve-the-conundrum-as-to-how-cytochrome-p450-oxidoreductase-and-cytochrome-b5-compete-for-the-same-binding-site-on-cytochrome-p450c17
#15
Jessica K Holien, Michael W Parker, Alan J Conley, C Jo Corbin, Raymond J Rodgers, Lisandra L Martin
Cytochrome P450 17α-hydroxylase, 17,20-lyase (P450c17) is a key enzyme in the synthesis of cortisol in the zona fascicula of the adrenal cortex, and the synthesis of androgen precursors in the adrenal zona reticularis and the gonads. Each of these reactions require electrons transferred by the electron donor cytochrome P450 oxidoreductase. The 17-hydroxylation of its substrate occurs in all cells where P450c17 is expressed. Remarkably, a second, subsequent reaction, namely the 17,20-lyase activity, only occurs in the zona reticularis and gonads...
December 20, 2016: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/27997498/quadratus-lumborum-block-conundrums-and-questions
#16
Luca La Colla, Bruce Ben-David
No abstract text is available yet for this article.
January 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/27992820/gja1-gene-variations-in-sudden-unexplained-nocturnal-death-syndrome-in-the-chinese-han-population
#17
Qiuping Wu, Yeda Wu, Liyong Zhang, Jinxiang Zheng, Shuangbo Tang, Jianding Cheng
Sudden unexplained nocturnal death syndrome (SUNDS) is a conundrum to both forensic pathologists and physicians, more than 80% of which the molecular pathogenesis remains unclear. Reported studies on both clinical and genetic phenotypes suggest SUNDS is related to congenital and acquired arrhythmias. Recent researches have linked the mutations of gene gap junction alpha 1 (GJA1) with arrhythmogenic cardiac disorders. In the present study, we investigate the potential correlation between GJA1 gene variations and the occurrence of SUNDS...
December 9, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27992394/the-conundrum-in-the-diagnosis-and-management-of-atypical-fulminant-measles-in-a-leukemia-survivor-on-maintenance-chemotherapy
#18
James Guoxian Huang, Allen Eng Juh Yeoh, Paul Anantharajah Tambyah, Mas Isa Suhaila
We report the diagnostic and therapeutic challenges in an unusually fulminant presentation of measles, presenting as severe necrotizing bronchiolitis with secondary hemophagocytic lymphohistiocytosis (HLH) in the absence of classical clinical features in an immunocompromised host on maintenance chemotherapy. Our patient had presented with features of a viral pneumonitis without the classical exanthem, in combination with HLH. Although rhinovirus-induced HLH was highly unusual, the positive rhinovirus swab result had distracted us from the eventual diagnosis...
January 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27989541/editorial-conundrums
#19
EDITORIAL
Philip D Lumb
No abstract text is available yet for this article.
February 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/27987285/the-changing-anatomic-position-of-squamous-cell-carcinoma-of-the-lung-a-new-conundrum
#20
William Krimsky, Nargiz Muganlinskaya, Saiyad Sarkar, Manasa Vulchi, Pujan Patel, Suman Rao, Joel Hammer, Ruth Evans, Muhammad Qureshi, Daniel Harley
BACKGROUND: Traditionally, squamous cell carcinoma (SCC) of the lung is a central rather than a peripheral form of lung cancer. Rates of SCC in the lung periphery are typically sited in the 15-30% range. Recently, we observed that a significant portion of newly diagnosed SCC was located on a periphery. A comprehensive review of the tumor data at our facility, a busy teaching hospital with a large cohort of cancer patients, was undertaken to assess whether there had been a substantive change in the traditional epidemiologic distributions of the lung cancer, specifically with respect to SCC...
2016: Journal of Community Hospital Internal Medicine Perspectives
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