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https://www.readbyqxmd.com/read/28544181/the-k-2-conundrum
#1
Jasmine K Janes, Joshua M Miller, Julian R Dupuis, René M Malenfant, Jamieson C Gorrell, Catherine I Cullingham, Rose L Andrew
Assessments of population genetic structure have become an increasing focus as they can provide valuable insight into patterns of migration and gene flow. STRUCTURE, the most highly cited of several clustering-based methods, was developed to provide robust estimates without the need for populations to be determined a priori. STRUCTURE introduces the problem of selecting the optimal number of clusters and as a result the ΔK method was proposed to assist in the identification of the 'true' number of clusters...
May 21, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28539452/interactions-between-hiv-1-gag-and-viral-rna-genome-enhance-virion-assembly
#2
Kari A Dilley, Olga A Nikolaitchik, Andrea Galli, Ryan C Burdick, Louis Levine, Kelvin Li, Alan Rein, Vinay K Pathak, Wei-Shau Hu
Most HIV-1 virions contain two copies of full-length viral RNA, indicating that genome packaging is efficient and tightly regulated. However, the structural protein Gag is the only component required for the assembly of noninfectious virus-like particles and the viral RNA is dispensable in this process. The mechanism that allows HIV-1 to achieve such high efficiency of genome packaging when a packageable viral RNA is not required for virus assembly is currently unknown. In this report, we examined the role of HIV-1 RNA in virus assembly and found that packageable HIV-1 RNA enhances particle production when Gag is expressed at levels similar to those in cells containing one provirus...
May 24, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28536849/nmd-monitors-translational-fidelity-24-7
#3
REVIEW
Alper Celik, Feng He, Allan Jacobson
Nonsense-mediated mRNA decay (NMD) is generally thought to be a eukaryotic mRNA surveillance pathway tasked with the elimination of transcripts harboring an in-frame premature termination codon (PTC). As presently conceived, NMD acting in this manner minimizes the likelihood that potentially toxic polypeptide fragments would accumulate in the cytoplasm. This notion is to be contrasted to the results of systematic RNA-Seq and microarray analyses of NMD substrates in multiple model systems, two different experimental approaches which have shown that many mRNAs identified as NMD substrates fail to contain a PTC...
May 23, 2017: Current Genetics
https://www.readbyqxmd.com/read/28532925/does-femtosecond-laser-assisted-cataract-surgery-improve-corneal-endothelial-safety-the-debate-and-conundrum
#4
EDITORIAL
David F Chang
No abstract text is available yet for this article.
April 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28529426/nasal-ala-reconstruction-surgical-conundrum
#5
Ana Ortins-Pina, Ana Isabel Teixeira, Maria Sanches, Ana Isabel Gouveia, Paulo Leal Filipe, João Maia Silva
No abstract text is available yet for this article.
January 2017: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/28523103/toward-resolving-the-resveratrol-conundrum-synthesis-and-in-vivo-pharmacokinetic-evaluation-of-bcp-resveratrol
#6
Yi Ling Goh, Yan Ting Cui, Vishal Pendharkar, Vikrant A Adsool
Over the last few decades, resveratrol has gained significance due to its impressive array of biological activities; however, its true potential as a drug has been severely constrained by its poor bioavailability. Indeed, several studies have implicated this bioavailability trait as a major road-block to resveratrol's potential clinical applications. To mitigate this pharmacokinetic issue, we envisioned a tactical bioisosteric modification of resveratrol to bicyclo[1.1.1]pentane (BCP) resveratrol. Relying on the beneficial bioisosteric potential demonstrated by the BCP-scaffold, we hypothesized that BCP-resveratrol would have an inherently better in vivo PK profile as compared to its natural counterpart...
May 11, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28521705/thalidomide-induced-deep-venous-thrombosis-in-a-case-of-steroid-dependent-erythema-nodosum-leprosum-a-management-conundrum
#7
Upinder Kaur, Sankha Shubhra Chakrabarti, Indrajeet Singh Gambhir, Rohit Singh
Thalidomide, previously banned owing to the issues of teratogenicity is being used and tested for a variety of dermatological and non dermatological conditions. The drug has been approved for the management of ENL and Multiple myeloma. The drug is commonly known to produce adverse effects like peripheral neuropathy and constipation. Deep vein thrombosis (DVT) is one of the serious adverse effects seen with thalidomide use, especially in malignancies and is relatively uncommon in non cancer settings like ENL...
May 18, 2017: Current Drug Safety
https://www.readbyqxmd.com/read/28503413/the-feeding-conundrum
#8
EDITORIAL
Sreeram Subramanian, Srinivas Murki
No abstract text is available yet for this article.
April 2017: Translational pediatrics
https://www.readbyqxmd.com/read/28501412/sudden-death-in-a-diver-a-diagnostic-conundrum
#9
Scott Dougherty, Maziar Khorsandi, Myra Adelbai, Vipin Zamvar, James Francis
We discuss the case of an experienced diver who ran out of air during his final ascent while scuba diving. He lost consciousness rapidly after surfacing and despite immediate cardiopulmonary resuscitation, could not be revived. On arrival at the emergency department he was noted to have copious amounts of blood in his upper airway and had developed extensive subcutaneous emphysema. Large amounts of air were observed in the central circulation following a postmortem computerized tomography scan as well as pneumomediastinum, a small right-sided hemothorax, and extensive subcutaneous emphysema...
May 10, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28500120/the-clinical-conundrum-of-diagnosing-and-treating-systemic-sarcoidosis-in-a-high-tb-burden-area
#10
Krishnadas Thulasidoss, Lavanya Asokan, Piyush Chandra, Pravinkumar Rejliwal
A 53-year-old woman from Southern India presented with weight loss, anorexia, fever and asthenia. Whole body positron emission tomography/computed tomography (PET-CT) showed fluorodeoxyglucose-avid mediastinal and abdominal lymphadenopathy with hepatic, splenic, parotid and lacrimal glandular inflammations. Endoscopic ultrasound-guided fine needle aspiration of subcarinal lymph node showed non-caseating granulomas. Initial serum ACE level was elevated but with normal calcium. Despite the suspicion of sarcoidosis, a trial of antituberculosis therapy was started empirically due to similar presentations of disseminated tuberculosis (TB) in this high endemic area...
May 12, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28499594/the-value-of-salvage-surgery-after-stereotactic-body-radiotherapy-failure-a-sticky-conundrum
#11
EDITORIAL
Benjamin Wei
No abstract text is available yet for this article.
April 23, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28479784/cerebral-microbleeds-treatment-conundrum-in-acute-ischemic-stroke
#12
EDITORIAL
Ramnath Santosh Ramanathan
No abstract text is available yet for this article.
April 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28478996/prediction-of-response-to-antipsychotics-in-patients-with-dementia-remains-a-conundrum
#13
EDITORIAL
D P Devanand
No abstract text is available yet for this article.
April 11, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28476940/mechanisms-of-regulation-and-diversification-of-deubiquitylating-enzyme-function
#14
REVIEW
Pawel Leznicki, Yogesh Kulathu
Deubiquitylating (or deubiquitinating) enzymes (DUBs) are proteases that reverse protein ubiquitylation and therefore modulate the outcome of this post-translational modification. DUBs regulate a variety of intracellular processes, including protein turnover, signalling pathways and the DNA damage response. They have also been linked to a number of human diseases, such as cancer, and inflammatory and neurodegenerative disorders. Although we are beginning to better appreciate the role of DUBs in basic cell biology and their importance for human health, there are still many unknowns...
May 5, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28476233/genetics-of-multiple-endocrine-neoplasia-type-1-multiple-endocrine-neoplasia-type-2-syndromes
#15
REVIEW
Samuel M Hyde, Gilbert J Cote, Elizabeth G Grubbs
Multiple endocrine neoplasia syndromes types 1 and 2 represent well-characterized yet clinically heterogeneous hereditary conditions for which diagnostic and management recommendations exist; genetic testing for these inherited endocrinopathies is included in these guidelines and is an important part of identifying affected patients and their family members. Understanding of these mature syndromes is challenged as more individuals undergo genetic testing and genetic data are amassed, with the potential to create clinical conundrums that may have an impact on individualized approaches to management and counseling...
June 2017: Endocrinology and Metabolism Clinics of North America
https://www.readbyqxmd.com/read/28475517/hailey-hailey-disease-with-coexistent-herpes-virus-infection-insights-into-the-diagnostic-conundrum-of-herpetic-pseudoherpetic-features-in-cutaneous-acantholytic-disorders
#16
Claire S Leitch, Anusha P Panthagani, Michael J Tidman, Asok Biswas
The specific histopathologic diagnosis of a primary acantholytic disorder takes into account the distribution and extent of acantholysis, presence or absence of dyskeratosis, nature of the dermal inflammatory cell infiltrate, and immunofluorescence findings. Herpes virus infection is a common cause of secondary acantholysis where distinctive viral cytopathic changes aid in making it a clear-cut diagnosis in majority of cases. We present a case of coexistence of Hailey-Hailey disease and herpes simplex virus infection to compare and contrast their histopathologic features...
April 25, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28474895/solving-the-density-functional-conundrum-elimination-of-systematic-errors-to-derive-accurate-reaction-enthalpies-of-complex-organic-reactions
#17
Arkajyoti Sengupta, Krishnan Raghavachari
The failure of available density functional methods to compute accurate reaction enthalpies of common organic reactions is well documented. Herein, we demonstrate that the disparate results from different functionals stem from the systematic errors in the underlying elementary reactions that represent the changes in the bonding environment between reactants and products. We develop a rigorous protocol to correct for these systematic errors and obtain dramatically improved results with deviations of only 1-2 kcal/mol for most functionals...
May 5, 2017: Organic Letters
https://www.readbyqxmd.com/read/28467481/pheromone-independent-unisexual-development-in-cryptococcus-neoformans
#18
Rachana Gyawali, Youbao Zhao, Jianfeng Lin, Yumeng Fan, Xinping Xu, Srijana Upadhyay, Xiaorong Lin
The fungus Cryptococcus neoformans can undergo a-α bisexual and unisexual reproduction. Completion of both sexual reproduction modes requires similar cellular differentiation processes and meiosis. Although bisexual reproduction generates equal number of a and α progeny and is far more efficient than unisexual reproduction under mating-inducing laboratory conditions, the α mating type dominates in nature. Population genetic studies suggest that unisexual reproduction by α isolates might have contributed to this sharply skewed distribution of the mating types...
May 3, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28466506/bolus-clearance-in-esophagogastric-junction-outflow-obstruction-is-associated-with-strength-of-peristalsis
#19
A Jain, J R Baker, J H Rubenstein, J W Chen
BACKGROUND: A manometric diagnosis of esophagogastric junction outflow obstruction (EGJOO) without a mechanical cause creates a therapeutic conundrum. The aim of this study was to assess esophageal bolus clearance in EGJOO and assess manometric factors associated with clearance in EGJOO. METHODS: Bolus clearance was assessed using line-tracing method and contour method to determine Complete Bolus Transit (CBT) and Functional Clearance (FC), respectively, on combined High-Resolution Impedance Manometry (HRIM)...
May 3, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28463143/the-conundrum-of-retroperitoneal-liposarcoma-to-be-more-aggressive-or-less-aggressive
#20
EDITORIAL
Elizabeth H Baldini
No abstract text is available yet for this article.
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
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