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https://www.readbyqxmd.com/read/28634266/30-years-of-the-mineralocorticoid-receptor-the-brain-mineralocorticoid-receptor-a-saga-in-three-episodes
#1
REVIEW
Marian Joëls, E Ronald de Kloet
In 1968, Bruce McEwen discovered that (3)H-corticosterone administered to adrenalectomised rats is retained in neurons of hippocampus rather than those of hypothalamus. This discovery signalled the expansion of endocrinology into the science of higher brain regions. With this in mind, our contribution highlights the saga of the brain mineralocorticoid receptor (MR) in three episodes. First, the precloning era dominated by the conundrum of two types of corticosterone-binding receptors in the brain, which led to the identification of the high-affinity corticosterone receptor as the 'promiscuous' MR cloned in 1987 by Jeff Arriza and Ron Evans in addition to the classical glucocorticoid receptor (GR)...
July 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28632576/understanding-the-constipation-conundrum-predictors-of-obtaining-an-abdominal-radiograph-during-the-emergency-department-evaluation-of-pediatric-constipation
#2
Claire A MacGeorge, Daniel C Williams, Natalie Vajta, Kristen Morella, Paul G Thacker, Scott Russell, William T Basco, David G Bundy
OBJECTIVES: Many children with constipation who are evaluated in emergency departments (EDs) receive an abdominal radiograph (AR) despite evidence-based guidelines discouraging imaging. The objectives of this study were to identify predictors associated with obtaining an AR and to determine if ARs were associated with a longer length of stay (LOS) among children with constipation evaluated in the ED. METHODS: A review of billing and electronic health records was conducted in an academic pediatric ED for children ages 0 to 17 years who had a primary discharge diagnosis of constipation from July 2013 to June 2014...
June 20, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28625203/understanding-temporal-relationships-between-depression-falls-and-physical-activity-in-a-cohort-of-post-hospitalized-older-adults-a-breakthrough-or-a-conundrum
#3
Den-Ching A Lee, Aislinn F Lalor, Grant Russell, Rene Stolwyk, Ted Brown, Fiona McDermott, Terry P Haines
BACKGROUND: Clinical depression affects approximately 15% of community-dwelling older adults, of which half of these cases present in later life. Falls and depressive symptoms are thought to co-exist, while physical activity may protect an older adult from developing depressive symptoms. This study investigates the temporal relationships between depressive symptoms, falls, and participation in physical activities amongst older adults recently discharged following extended hospitalization...
June 19, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28623706/primary-inferior-vena-cava-smooth-muscle-tumor-with-diffuse-bizarre-giant-nuclei-and-low-mitotic-rate-a-nomenclatural-conundrum
#4
Runjan Chetty, Sangeetha N Kalimuthu, Hanna-Riikka Heinonen
A male patient with obstructive jaundice was found to have an incidental nodule within the inferior vena cava (IVC), below the level of the renal vein, on abdominal imaging. At the time of the Whipple's procedure for pancreatic adenocarcinoma, the IVC mass measuring 3.4×2.7×2.2 cm was also removed. Histologically, the lesion was well circumscribed, composed focally of spindle-shaped cells with cigar-shaped nuclei reminiscent of smooth muscle and a dominant pervasive, pleomorphic, bizarre giant cell component...
June 4, 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/28621485/the-conundrums-of-human-development-implications-for-the-study-of-child-and-adolescent-disorder
#5
EDITORIAL
Alice M Gregory
The conundrums inherent in the study of child and adolescent development are likely never far from the minds of the readers of JCPP. The complexity of development is flagged clearly in this issue. Included papers remind us that the link between associations (here maternal depression and child internalising problems) can change over short time periods. Even when the magnitude of associations stay consistent over time (here between the home environment and depression), there may be different aetiological processes underlying these links...
July 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28616183/dissecting-spatiotemporal-patterns-of-functional-diversity-through-the-lens-of-darwin-s-naturalization-conundrum
#6
Sara E Campbell, Nicholas E Mandrak
Darwin's naturalization conundrum describes the paradigm that community assembly is regulated by two opposing processes, environmental filtering and competitive interactions, which predict both similarity and distinctiveness of species to be important for establishment. Our goal is to use long-term, large-scale, and high-resolution temporal data to examine diversity patterns over time and assess whether environmental filtering or competition plays a larger role in regulating community assembly processes. We evaluated Darwin's naturalization conundrum and how functional diversity has changed in the Laurentian Great Lakes fish community from 1870 to 2010, which has experienced frequent introductions of non-native species and extirpations of native species...
June 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28601560/stochastic-modeling-yields-a-mechanistic-framework-for-spindle-attachment-error-correction-in-budding-yeast-mitosis
#7
Emily S Tubman, Sue Biggins, David J Odde
Proper segregation of the replicated genome requires that kinetochores form and maintain bioriented, amphitelic attachments to microtubules from opposite spindle poles and eliminate erroneous, syntelic attachments to microtubules from the same spindle pole. Phosphorylation of kinetochore proteins destabilizes low-tension kinetochore-microtubule attachments, yet tension stabilizes bioriented attachments. This conundrum for forming high-tension amphitelic attachments is recognized as the "initiation problem of biorientation (IPBO)...
June 6, 2017: Cell Systems
https://www.readbyqxmd.com/read/28596233/adaptable-interaction-between-aquaporin-1-and-band-3-reveals-a-potential-role-of-water-channel-in-blood-co2-transport
#8
Kate Hsu, Ting-Ying Lee, Ammasi Periasamy, Fu-Jen Kao, Li-Tzu Li, Chuang-Yu Lin, Hui-Ju Lin, Marie Lin
Human CO2 respiration requires rapid conversion between CO2 and HCO3(-) Carbonic anhydrase II facilitates this reversible reaction inside red blood cells, and band 3 [anion exchange (AE)-1] provides a passage for HCO3(-) flux across the cell membrane. These 2 proteins are core components of the CO2 transport metabolon. Intracellular H2O is necessary for CO2/HCO3(-) conversion. However, abundantly expressed aquaporin (AQP)-1 in erythrocytes is thought not to be part of band 3 complexes or the CO2 transport metabolon...
June 8, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28594780/clinical-conundrums-is-one-clinician-s-quandary-the-next-clinical-trial
#9
Mark A Turrentine
No abstract text is available yet for this article.
June 6, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28590947/the-conundrum-of-equitable-organ-allocation-in-heart-transplantation-the-moving-target-of-candidate-risk-score
#10
Luciano Potena, Kiran K Khush
No abstract text is available yet for this article.
June 6, 2017: Transplantation
https://www.readbyqxmd.com/read/28587525/the-conundrum-of-h2o2-signaling-and-the-emerging-role-of-peroxiredoxins-as-redox-relay-hubs
#11
Sarah Stöcker, Koen Van Laer, Ana Mijuskovic, Tobias P Dick
SIGNIFICANCE: H2O2 is known to act as a messenger in signal transduction. How H2O2 leads to selective and efficient oxidation of specific thiols on specific signaling proteins remains one of the most important open questions in redox biology. Recent Advances: Increasing evidence implicates thiol peroxidases as mediators of protein thiol oxidation. Recently, this evidence has been extended to include the peroxiredoxins. Peroxiredoxins are exceptionally sensitive to H2O2, abundantly expressed and capture most of the H2O2 that is generated inside cells...
June 6, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28584696/redefining-acute-relapses-in-multiple-sclerosis-implications-for-phase-3-clinical-trials-and-treatment-algorithms
#12
EDITORIAL
Jagannadha Avasarala
Relapses in multiple sclerosis are defined as periods of clinical worsening and radiological progression. Magnetic resonance imaging data, however, are not always supportive of "clinical worsening," and clinical symptoms of worsening may not always be present in cases of acute relapse. In the pharmaceutical domain, this discordance between "clinical worsening" and "radiological progression" has never been fully elucidated, and no Phase 3 clinical study has addressed this conundrum. Thus, the true number of acute relapse cases enrolled in Phase 3 clinical studies remains unclear...
March 2017: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/28584380/prospective-study-design-conundrum-disease-registry-for-cutaneous-leishmaniasis
#13
Kanica Kaushal
No abstract text is available yet for this article.
May 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28577336/on-discontinuing-treatment-in-schizophrenia-a-clinical-conundrum
#14
EDITORIAL
Robin Emsley
No abstract text is available yet for this article.
January 12, 2017: NPJ Schizophrenia
https://www.readbyqxmd.com/read/28572093/heart-rhythm-conundrum
#15
Rhodri Huw Davies, Dewi Eurfyl Thomas
No abstract text is available yet for this article.
June 1, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28569807/upgrading-protected-areas-to-conserve-wild-biodiversity
#16
Robert M Pringle
International agreements mandate the expansion of Earth's protected-area network as a bulwark against the continued extinction of wild populations, species, and ecosystems. Yet many protected areas are underfunded, poorly managed, and ecologically damaged; the conundrum is how to increase their coverage and effectiveness simultaneously. Innovative restoration and rewilding programmes in Costa Rica's Área de Conservación Guanacaste and Mozambique's Parque Nacional da Gorongosa highlight how degraded ecosystems can be rehabilitated, expanded, and woven into the cultural fabric of human societies...
May 31, 2017: Nature
https://www.readbyqxmd.com/read/28567321/neuropsychiatric-manifestations-in-a-patient-with-panhypopituitarism
#17
Oluwole Jegede, Ajouka Jeyakumar, Thyarapan Balakumar, Alyssa Raghu, Katherine I Chang, Katarina Soewono, Mario Gustave, Ayodeji Jolayemi
We present a case of an incidental diagnosis of panhypopituitarism in a 68-year-old African American man admitted to our psychiatric inpatient unit with symptoms suggestive of schizophrenia. The case was unusual as a first-episode psychosis given the patient's age. In the course of his admission, the patient's clinical condition deteriorated culminating in a sudden altered mental status which prompted a transfer to the medical floors and further investigations. A head CT scan and a pituitary MRI revealed a near total resection of the pituitary while laboratory investigations revealed hyponatremia and a grossly low hormone profile...
2017: Case Reports in Psychiatry
https://www.readbyqxmd.com/read/28560250/on-discontinuing-treatment-in-schizophrenia-a-clinical-conundrum
#18
EDITORIAL
Robin Emsley
No abstract text is available yet for this article.
2017: NPJ Schizophrenia
https://www.readbyqxmd.com/read/28553383/hemophagocytic-lymphohistiocytosis-a-diagnostic-conundrum
#19
Brittany Grzybowski, Vijay A Vishwanath
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of excessive immune activation causing widespread inflammation and tissue destruction leading to multi-organ dysfunction and failure. Making the diagnosis of HLH could be quite challenging due to the broad range of presenting symptoms and their lack of specificity. After ruling out considerations for differential diagnoses, recognizing the most common presenting signs and symptoms of HLH, including neurologic dysfunction, and having a high clinical suspicion for HLH in the setting of inflammatory/demyelinating diseases are important for prompt diagnosis and treatment...
January 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/28553153/interprofessional-education-development-not-for-the-faint-of-heart
#20
Deborah B Fahs, Linda Honan, Rosana Gonzalez-Colaso, Eve R Colson
Interprofessional education (IPE) has the potential to improve communication, collaboration and coordination of care, leading to improved health care outcomes. Promoting IPE has become an aim for many professional schools. However, there are challenges to implementing meaningful curricula that involve multiple health care professional schools. In this study, we outline 12 lessons learned when designing and implementing an Interprofessional Longitudinal Clinical Experience (ILCE) for 247 students from a School of Nursing, Medicine and Physician Associate Program in New England...
2017: Advances in Medical Education and Practice
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