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https://www.readbyqxmd.com/read/29149459/the-economic-impact-of-nursing
#1
EDITORIAL
Sharon M Brownie
Economics includes 'the condition of a region or group as regards material prosperity' (Oxford Dictionaries, 2017). The links between material prosperity versus poverty, health status and quality of life are well documented as are the devastating impacts of population disparities on the aforementioned indicators (Association of State and Territorial Health Officials, 2012). Poor health affects the ability of people to work, generate income and care for their families- a widely understood conundrum. In short, economic position impacts health status and health status impacts economic prosperity...
November 17, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29147590/paroxysmal-nocturnal-hemoglobinuria-in-pregnancy-a-dilemma-in-treatment-and-thromboprophylaxis
#2
Arpan Patel, Athira Unnikrishnan, Martina Murphy, Robert Egerman, Sarah Wheeler, Ashley Richards, John Wingard
Paroxysmal nocturnal hemoglobinuria (PNH) is a hematologic disorder characterized by an acquired somatic mutation in the phosphatidylinositol glycan class A gene which leads to a higher risk for increased venous and arterial thrombosis. Current treatment for PNH includes eculizumab. Pregnant patients who have PNH have higher risk for thrombosis and hemorrhage with both pregnancy and their underlying PNH. Treatment frequently poses conundrum. The safety and efficacy of eculizumab during pregnancy and breast feeding have not been extensively studied and contraception has been recommended due to potential for teratogenicity...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/29145378/the-cloud-conundrum
#3
Kate Marvel
No abstract text is available yet for this article.
November 14, 2017: Scientific American
https://www.readbyqxmd.com/read/29144862/are-physician-orders-for-life-sustaining-treatments-the-answer-to-the-end-of-life-care-quality-conundrums-in-cancer-care
#4
Keith M Swetz
No abstract text is available yet for this article.
November 16, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29141887/apoptosis-in-mesenchymal-stromal-cells-induces-in-vivo-recipient-mediated-immunomodulation
#5
Antonio Galleu, Yanira Riffo-Vasquez, Cristina Trento, Cara Lomas, Luigi Dolcetti, Tik Shing Cheung, Malte von Bonin, Laura Barbieri, Krishma Halai, Sophie Ward, Ling Weng, Ronjon Chakraverty, Giovanna Lombardi, Fiona M Watt, Kim Orchard, David I Marks, Jane Apperley, Martin Bornhauser, Henning Walczak, Clare Bennett, Francesco Dazzi
The immunosuppressive activity of mesenchymal stromal cells (MSCs) is well documented. However, the therapeutic benefit is completely unpredictable, thus raising concerns about MSC efficacy. One of the affecting factors is the unresolved conundrum that, despite being immunosuppressive, MSCs are undetectable after administration. Therefore, understanding the fate of infused MSCs could help predict clinical responses. Using a murine model of graft-versus-host disease (GvHD), we demonstrate that MSCs are actively induced to undergo perforin-dependent apoptosis by recipient cytotoxic cells and that this process is essential to initiate MSC-induced immunosuppression...
November 15, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/29134360/protein-kinase-c-in-the-cerebellum-its-significance-and-remaining-conundrums
#6
REVIEW
Hirokazu Hirai
Protein kinase C (PKC), a family of serine/threonine protein kinases, mediates a myriad of patho-physiological cellular events in various tissues. The originally discovered PKC (conventional) requires the binding of diacylglycerol and Ca(2+) for full activation. The conventional PKC consists of four isoforms, PKCα, PKCβI/βII, and PKCγ. PKCα and PKCβI/βII are expressed in the cells of various tissues including the brain, while PKCγ is present specifically in neurons of the brain and spinal cord. The cerebellum expresses the largest amount of PKC with all its four isoforms...
November 13, 2017: Cerebellum
https://www.readbyqxmd.com/read/29134273/o-cdc7-kinase-where-art-thou
#7
Robert A Sclafani, Jay R Hesselberth
Although Cdc7 protein kinase is important for regulating DNA replication in all eukaryotes and is a target for cancer therapy, it has never been localized in cells. Recently, a novel molecular genomic method used by our laboratory to localize Cdc7 to regions of chromosomes. Originally, mutations in the CDC7 gene were found in the classic cdc mutant collection of Hartwell et al. (Genetics 74:267-286, 1973). The CDC7 gene was found to encode a protein kinase called DDK that has been studied for many years, establishing its precise role in the initiation of DNA replication at origins...
November 13, 2017: Current Genetics
https://www.readbyqxmd.com/read/29134200/intraoceanic-subduction-spanned-the-pacific-in-the-late-cretaceous-paleocene
#8
Mathew Domeier, Grace E Shephard, Johannes Jakob, Carmen Gaina, Pavel V Doubrovine, Trond H Torsvik
The notorious ~60° bend separating the Hawaiian and Emperor chains marked a prominent change in the motion of the Pacific plate at ~47 Ma (million years ago), but the origin of that change remains an outstanding controversy that bears on the nature of major plate reorganizations. Lesser known but equally significant is a conundrum posed by the pre-bend (~80 to 47 Ma) motion of the Pacific plate, which, according to conventional plate models, was directed toward a fast-spreading ridge, in contradiction to tectonic forcing expectations...
November 2017: Science Advances
https://www.readbyqxmd.com/read/29130448/a-review-on-the-effects-of-current-chemotherapy-drugs-and-natural-agents-in-treating-non-small-cell-lung-cancer
#9
Chih-Yang Huang, Da-Tong Ju, Chih-Fen Chang, P Muralidhar Reddy, Bharath Kumar Velmurugan
Lung cancer is the leading cause of cancer deaths worldwide, and this makes it an attractive disease to review and possibly improve therapeutic treatment options. Surgery, radiation, chemotherapy, targeted treatments, and immunotherapy separate or in combination are commonly used to treat lung cancer. However, these treatment types may cause different side effects, and chemotherapy-based regimens appear to have reached a therapeutic plateau. Hence, effective, better-tolerated treatments are needed to address and hopefully overcome this conundrum...
December 2017: BioMedicine
https://www.readbyqxmd.com/read/29130411/the-implant-conundrum
#10
John R Lewis
No abstract text is available yet for this article.
December 2017: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/29127765/high-aldosterone-and-cortisol-levels-in-salt-wasting-congenital-adrenal-hyperplasia-a-clinical-conundrum
#11
Sirisha Kusuma Boddu, Sheeja Madhavan
BACKGROUND: Salt wasting syndrome (hyponatremia, hyperkalemia, dehydration, metabolic acidosis) in early infancy could be caused by either mineralocorticoid deficiency as in congenital adrenal hyperplasia (CAH) and adrenal insufficiency or mineralocorticoid resistance as in pseudohypoaldosteronism (PHA). In salt wasting CAH, serum aldosterone and cortisol levels are expected to be low. Cross reactivity between high levels of adrenal steroid precursors and aldosterone has recently been reported resulting in elevated aldosterone levels in CAH, leading to difficulty in differentiating between CAH and PHA...
November 11, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29127137/ethics-of-treatment-interruption-trials-in-hiv-cure-research-addressing-the-conundrum-of-risk-benefit-assessment
#12
Gail E Henderson, Holly L Peay, Eugene Kroon, Rosemary Jean Cadigan, Karen Meagher, Thidarat Jupimai, Adam Gilbertson, Jill Fisher, Nuchanart Q Ormsby, Nitiya Chomchey, Nittaya Phanuphak, Jintanat Ananworanich, Stuart Rennie
Though antiretroviral therapy is the standard of care for people living with HIV, its treatment limitations, burdens, stigma and costs lead to continued interest in HIV cure research. Early-phase cure trials, particularly those that include analytic treatment interruption (ATI), involve uncertain and potentially high risk, with minimal chance of clinical benefit. Some question whether such trials should be offered, given the risk/benefit imbalance, and whether those who choose to participate are acting rationally...
November 10, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/29121206/effects-of-temperatures-on-immature-development-and-survival-of-the-invasive-stink-bug-hemiptera-pentatomidae
#13
Darcy A Reed, Fatemeh Ganjisaffar, John C Palumbo, Thomas M Perring
Bagrada hilaris (Burmeister) (Hemiptera: Pentatomidae) is a non-native stink bug that feeds primarily on cole crops and wild mustards. Its invasion into desert agriculture in California and Arizona presents a conundrum between rapid pest development at warm temperatures and severe damage to cool season crops. In this study, the development and survival of B. hilaris were determined at nine constant temperatures (ranging from 20-42°C) when reared on organically grown broccoli florets. Egg hatching was greatly delayed at 20°C, and first instar nymphs did not survive at this temperature...
November 7, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29118838/a-complex-obstetric-case
#14
Michael Hoy, Kate Flavin, Venkat Prasad
A 33-year-old primigravida presented with severe sepsis, severe pre-eclampsia, peripartum cardiomyopathy and the haemolysis, elevated liver enzymes and low platelets syndrome manifesting over the course of 24 h causing a diagnostic conundrum and a difficult sequence of physiological problems to overcome. We describe a previously unreported sequence of events involving a pre-eclamptic, septic parturient to improve anaesthetic and intensive care physician awareness of confounding factors that complicate assessment and management of these patients...
August 2017: J Intensive Care Soc
https://www.readbyqxmd.com/read/29118041/marijuana-legalization-a-continuing-conundrum
#15
EDITORIAL
Edward P Krenzelok
No abstract text is available yet for this article.
November 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29109942/ductal-carcinoma-in-situ-biology-biomarkers-and-diagnosis
#16
REVIEW
Kylie L Gorringe, Stephen B Fox
Ductal carcinoma in situ (DCIS) is an often-diagnosed breast disease and a known, non-obligate, precursor to invasive breast carcinoma. In this review, we explore the clinical and pathological features of DCIS, fundamental elements of DCIS biology including gene expression and genetic events, the relationship of DCIS with recurrence and invasive breast cancer, and the interaction of DCIS with the microenvironment. We also survey how these various elements are being used to solve the clinical conundrum of how to optimally treat a disease that has potential to progress, and yet is also likely over-treated in a significant proportion of cases...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29109494/not-too-hot-not-too-cold-but-just-right
#17
Brian J Hanson, Aasma Shaukat
When ordering diagnostic tests, physicians are faced with a problem of not too many tests, not too few, but 'just right'. However, in medical diagnostics 'just right' may be very difficult to identify. Such is the conundrum presented in study by Rubenstein and colleagues regarding appropriate use of repeat esophagogastroduodenoscopy (EGD) in Veterans Health Administration (VHA) medical facilities. The important message of this paper is that out of 235,855 patients with an index EGD, 36% underwent repeat EGD over 5 years, of which only 9% (range 3-18%a cross VHA facilities) were classified as probable overuse...
November 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29107885/structure-based-mechanistic-insights-into-catalysis-by-small-self-cleaving-ribozymes
#18
REVIEW
Aiming Ren, Ronald Micura, Dinshaw J Patel
Small self-cleaving ribozymes are widely distributed in nature and are essential for rolling-circle-based replication of satellite and pathogenic RNAs. Earlier structure-function studies on the hammerhead, hairpin, glmS, hepatitis delta virus and Varkud satellite ribozymes have provided insights into their overall architecture, their catalytic active site organization, and the role of nearby nucleobases and hydrated divalent cations in facilitating general acid-base and electrostatic-mediated catalysis. This review focuses on recent structure-function research on active site alignments and catalytic mechanisms of the Rzb hammerhead ribozyme, as well as newly-identified pistol, twister and twister-sister ribozymes...
November 3, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/29102008/editorial-commentary-the-long-head-of-the-biceps-brachii-tendon-the-shoulder-surgeon-s-conundrum
#19
EDITORIAL
Michael G Ciccotti
The long head of the biceps tendon can be a significant pain generator in the setting of rotator cuff tearing. Surgeons who encounter long head of biceps tendon pathology at the time of rotator cuff repair can be confident in a high likelihood of statistically significant clinical improvement with concomitant long head of biceps surgery. Patients can be reliably counseled preoperatively that if they have both clinically apparent long head of biceps tendon pathology and rotator cuff tearing, and if they undergo long head of biceps tendon surgery with rotator cuff repair, they can expect comparable or better outcomes than isolated rotator cuff repair...
November 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29093000/pandora-s-prescription-the-pharmaceutical-pricing-vs-cost-conundrum
#20
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
November 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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