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https://www.readbyqxmd.com/read/28732101/the-conundrum-of-digital-medicine
#1
EDITORIAL
David A Fisher
No abstract text is available yet for this article.
July 1, 2017: Orthopedics
https://www.readbyqxmd.com/read/28731910/new-answers-to-old-conundrums-what-antibodies-exosomes-and-inflammasomes-bring-to-the-conversation-canadian-national-transplant-research-program-international-summit-report
#2
Mélanie Dieudé, Lori J West, Daniel A Muruve, Lakshman Gunaratman, Thalachallour Mohanakumar, Emmanuel Zorn, Christopher W Cairo, Darren H Freed, Kirk R Schultz, Robert L Fairchild, Marie-Josée Hébert
Antibody-mediated injury is a major cause of allograft dysfunction and loss. Antibodies to ABH(O) blood group antigens are classical mediators of ABO-incompatible (ABOi) graft rejection, while donor-specific anti-HLA antibodies and, more recently, autoantibodies are appreciated as important contributors to allograft inflammation and dysfunction. In August 2016, the International Summit of the Canadian National Transplant Research Program focused on recent advances in the field of antibody-mediated rejection...
July 21, 2017: Transplantation
https://www.readbyqxmd.com/read/28727153/month-of-birth-is-associated-with-the-subsequent-diagnosis-of-autoimmune-hypothyroidism-a-nationwide-danish-register-based-study
#3
Marianne Thvilum, Frans Brandt, Thomas Heiberg Brix, Laszlo Hegedüs
BACKGROUND: The triggering of thyroid autoimmunity in the genetically susceptible remains a conundrum. Environmental exposures during gestation and/or early postnatally have proponents, as suggested in diabetes mellitus, with a higher incidence of births during spring and summer. Whether the development of autoimmune hypothyroidism (AIT) is influenced by month or season of birth is less clear. METHOD: Nationwide cohort study of 111,565 individuals diagnosed with AIT and four euthyroid controls per case, matched according to age and sex, were identified from Danish health registers...
July 20, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28725484/logarithmic-sensing-in-bacillus-subtilis-aerotaxis
#4
Filippo Menolascina, Roberto Rusconi, Vicente I Fernandez, Steven Smriga, Zahra Aminzare, Eduardo D Sontag, Roman Stocker
Aerotaxis, the directed migration along oxygen gradients, allows many microorganisms to locate favorable oxygen concentrations. Despite oxygen's fundamental role for life, even key aspects of aerotaxis remain poorly understood. In Bacillus subtilis, for example, there is conflicting evidence of whether migration occurs to the maximal oxygen concentration available or to an optimal intermediate one, and how aerotaxis can be maintained over a broad range of conditions. Using precisely controlled oxygen gradients in a microfluidic device, spanning the full spectrum of conditions from quasi-anoxic to oxic (60 n mol/l-1 m mol/l), we resolved B...
2017: NPJ Systems Biology and Applications
https://www.readbyqxmd.com/read/28715579/use-of-neoadjuvant-platinum-the-ongoing-conundrum
#5
Hope S Rugo, Karen Gelmon
No abstract text is available yet for this article.
July 13, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28711094/the-tattoo-removal-ethical-conundrum-should-a-physician-be-part-of-a-minor-patient-s-punishment
#6
Kousanee Chheda, Breton Yates, Hanspaul S Makkar, Jane M Grant-Kels
No abstract text is available yet for this article.
August 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28711073/lupus-nephritis-and-pregnancy-concerns-and-management
#7
Liz Lightstone, Michelle A Hladunewich
Pregnancy associated with lupus, especially lupus nephritis, is often fraught with concern for both the mother and fetus. Thus, it is paramount that care begins preconception so that proper planning in terms of optimizing the medical regimen, discontinuation of fetotoxic agents, and treatment of active disease can occur. It is well known that active nephritis at the time of conception is associated with poor outcomes. Even with quiescent disease, recent data indicate that being lupus anticoagulant-positive, nonwhite or Hispanic, and using antihypertensive medications were all predictors of worse pregnancy outcomes...
July 2017: Seminars in Nephrology
https://www.readbyqxmd.com/read/28710200/thyrotoxicosis-in-patients-with-hypothyroidism-is-not-just-overtreatment
#8
Punith Kempegowda, Ananth U Nayak
A 62-year-old Caucasian woman presented with hypothyroid symptoms and biochemical thyrotoxic picture. Previously, she underwent right-sided subtotal thyroidectomy and left partial thyroid lobectomy for thyroid lumps, and treated with thyroxine replacement for hypothyroidism. Although there were no significant findings on clinical examination, investigations confirmed thyrotoxicosis with positive autoimmunity against thyroid glandâ€"all in line with a diagnosis of Graves’ hyperthyroidism. We would like to highlight atypical presentations of thyroid dysfunction and conversion of underactive to overactive thyroid status with this case...
July 14, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28706972/fever-and-pancytopenia-in-a-liver-transplant-recipient-going-against-the-rules-of-occam-s-razor
#9
Lionel Hon Wai Lum, Fei Wen Chen, Louise Jackett, Simone I Strasser, Rebecca J Davis
The syndrome of fever and pancytopenia is not infrequently encountered postliver transplant, and a broad differential list of infectious and noninfectious aetiologies can be invoked. A transplant patient is susceptible to more than 1 opportunistic infection or disease process. We described the diagnostic conundrums in managing our patient who ran a complex protracted course postliver transplant. He was diagnosed to have both disseminated tuberculosis and graft-versus-host disease, a rare complication after solid organ transplantation...
July 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28701965/the-depression-conundrum-and-the-advantages-of-uncertainty
#10
REVIEW
Jan E Celie, Tom Loeys, Mattias Desmet, Paul Verhaeghe
According to the WHO (2012), the prevalence of unipolar depressive disorders is rising, even in those places where mental health treatments are widely available. The WHO predicts that these disorders will be the leading contributor to the global burden of disease by 2030. This sobering projection fits poorly with how psychological treatments for depression are presented in the mainstream scientific literature: as highly effective therapies, based upon a sound understanding of the causes of distress. There is a clear discrepancy between the rising prevalence figures on the one hand, and the confident claims of this effectiveness research on the other...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28701807/natriuretic-peptides-as-biomarkers-for-congestive-states-the-cardiorenal-divergence
#11
REVIEW
Abhilash Koratala, Amir Kazory
Congestion represents the primary reason for hospitalization of patients with heart failure and is associated with adverse outcomes. Fluid overload has been shown to be inadequately addressed in a significant subset of these patients in part due to lack of robust, reliable, and readily available biomarkers for objective assessment and monitoring of therapy. Natriuretic peptides have long been used in this setting, often in conjunction with other assessment tools such as imaging studies. Patients presenting with concomitant cardiac and renal dysfunction represent a unique population with regard to congestion in that the interactions between the heart and the kidney can affect the utility and performance of biomarkers of fluid overload...
2017: Disease Markers
https://www.readbyqxmd.com/read/28698293/the-conundrum-of-permanent-pacemaker-implantation-after-transcatheter-aortic-valve-implantation
#12
EDITORIAL
Anna Franzone, Stephan Windecker
No abstract text is available yet for this article.
July 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28690716/wilson-s-disease-and-diagnostic-conundrum-in-a-low-income-country
#13
Pratap Kumar Patra
Wilson's disease is a well-known leading cause of chronic liver disease in children. However it may remain undiagnosed in a resource limited setting for a long period. We describe a six year male child diagnosed Wilson's disease with extreme elevation of liver enzymes which is not reported earlier. The diagnosis was also baffling because of inconsistency of other laboratory parameters.
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28684677/the-role-of-the-core-non-homologous-end-joining-factors-in-carcinogenesis-and-cancer
#14
REVIEW
Brock J Sishc, Anthony J Davis
DNA double-strand breaks (DSBs) are deleterious DNA lesions that if left unrepaired or are misrepaired, potentially result in chromosomal aberrations, known drivers of carcinogenesis. Pathways that direct the repair of DSBs are traditionally believed to be guardians of the genome as they protect cells from genomic instability. The prominent DSB repair pathway in human cells is the non-homologous end joining (NHEJ) pathway, which mediates template-independent re-ligation of the broken DNA molecule and is active in all phases of the cell cycle...
July 6, 2017: Cancers
https://www.readbyqxmd.com/read/28679822/conundrums-at-the-end-of-life
#15
Jerald Winakur
No abstract text is available yet for this article.
July 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28675183/communication-breakdown-between-physicians-and-ibs-sufferers-what-is-the-conundrum-and-how-to-overcome-it
#16
T Jayaraman, R K Wong, D A Drossman, Y Y Lee
Irritable bowel syndrome is a disorder of gut-brain interaction that leads to a significant healthcare burden worldwide. A good physician-patient relationship is fundamental in managing patients who suffer from this poorly understood chronic disease. We highlight possible reasons for breakdown in communication between physicians and irritable bowel syndrome sufferers and suggest possible ways to overcome such pitfalls.
June 2017: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/28670912/mandibular-lytic-lesion-in-familial-paraganglioma-syndrome-type-i-a-clinical-conundrum
#17
Parul Sinha, Sonia N Yuen, Rebecca D Chernock, Bruce H Haughey
OBJECTIVE: The entity of primary mandibular paraganglioma (PGL) is not well accepted within the head and neck. Mandibular PGLs hitherto reported in literature are malignant metastatic lesions, mostly from a pheochromocytoma. METHODS: We report a case of mandibular lytic lesion in a young female with multifocal PGLs but no family history of PGLs. We also performed a literature search to identify published cases of mandibular PGL. RESULTS: Lack of established criteria for malignancy in a PGL made diagnosis and treatment challenging...
June 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28664856/controversies-and-conundrums-in-vocal-cord-dysfunction
#18
Philip G Bardin, Kathy Low, Laurence Ruane, Kenneth K Lau
No abstract text is available yet for this article.
July 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28658502/immediate-moxifloxacin-hypersensitivity-is-there-more-than-currently-meets-the-eye
#19
Athina L Van Gasse, Vito Sabato, A P Uyttebroek, Jessy Elst, Margaretha A Faber, Margo M Hagendorens, Christel Mertens, Chris H Bridts, Luc S De Clerck, Didier G Ebo
Immediate drug hypersensitivity reactions (IDHR) to moxifloxacin constitute a pathomechanistic conundrum and a diagnostic challenge. Our objective was to study whether simultaneous phenotyping and quantification of histamine release might add to our knowledge about the basophil activation properties of moxifloxacin and constitute a reliable diagnostic aid. Fifteen patients with an IDHR to moxifloxacin and 9 moxifloxacin challenged controls were selected. All had a basophil activation test (BAT) with moxifloxacin...
June 28, 2017: Allergy
https://www.readbyqxmd.com/read/28644134/the-conundrum-of-the-epstein-barr-virus-associated-gastric-carcinoma-in-the-americas
#20
REVIEW
Gonzalo Carrasco-Avino, Ismael Riquelme, Oslando Padilla, Miguel Villaseca, Francisco R Aguayo, Alejandro H Corvalan
Epstein-Barr virus-associated gastric carcinoma shows a higher prevalence in the Americas than Asia. We summarize all studies of Epstein Barr virus-associated gastric carcinoma in the Americas, focusing on host characteristics, environmental associations and phylogeographic diversity of Epstein-Barr virus strains. In the Americas, the prevalence of Epstein Barr virus-associated gastric carcinoma is 11.4%, more frequent in males and portray predominantly diffuse-type histology. EBERs, EBNAs, BARTs and LMP are the highest expressed genes; their variations in healthy individuals may explain the phylogeographic diversity of Epstein-Barr virus across the region...
June 15, 2017: Oncotarget
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