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Siddharth Jain, Animesh Ray, Manish Soneja, S Leve Joseph Devarajan, Shyam Madabhushi, Anitha Swamy, T Naveen, S K Sharma
A known case of primary Sjogren's syndrome with chronic kidney disease presented with respiratory symptoms and subsequent altered sensorium. Chest imaging suggested cavitating lung lesions in both the lungs. Serum c-ANCA was positive without any upper respiratory tract involvement or active urinary sediments. Treatment with appropriate anti-microbials produced no improvement in the respiratory or neurological parameters. MRI brain revealed tell-tale signs of CNS vascultis. A diagnosis of GPA was made as per European Medical Agency algorithm and the patient was started on immune-suppressants to which there was dramatic response...
October 2016: Journal of the Association of Physicians of India
Ann Esquivel, William W Busse
Anaphylaxis is a serious and potentially life-threatening allergic reaction that may follow the ingestion of foods. Although these reactions usually follow a common clinical pattern and often demonstrate IgE sensitization to the antigen in question, both the clinical presentation and causative allergen may be atypical, surprising, and difficult to identify. Failure to identify the actual cause of the reaction can compromise treatment and complicate long-term care. Here, we present a patient who had symptoms of anaphylaxis after eating salmon, but confirmation of the causative allergen was not readily apparent...
October 17, 2016: Journal of Allergy and Clinical Immunology in Practice
Laurel L Ballantyne, Yuan Yan Sin, Osama Y Al-Dirbashi, Xinzhi Li, David J Hurlbut, Colin D Funk
Arginase-1 (Arg1) converts arginine to urea and ornithine in the distal step of the urea cycle in liver. We previously generated a tamoxifen-inducible Arg1 deficient mouse model (Arg1-Cre) that disrupts Arg1 expression throughout the whole body and leads to lethality ≈ 2 weeks after gene disruption. Here, we evaluate if liver-selective Arg1 loss is sufficient to recapitulate the phenotype observed in global Arg1 knockout mice, as well as to gauge the effectiveness of gene delivery or hepatocyte transplantation to rescue the phenotype...
December 2016: Molecular Genetics and Metabolism Reports
Antonio Zingarelli, Sara Seitun, Roberto Delfino, Alberto Valbusa, Manrico Balbi, Claudio Brunelli
No abstract text is available yet for this article.
December 2016: Minerva Cardioangiologica
Anjali Nagpal, Chris Juttner, Monica Anne Hamilton-Bruce, Paul Rolan, Simon A Koblar
The encouraging pace of discovery and development in the field of regenerative medicine holds tremendous potential for bringing therapies to the clinic that may offer meaningful benefit to patients, particularly in diseases with no or suboptimal therapeutic options. Academic researchers will continue to play a critical role in developing concepts and therapies, thus determining whether regenerative medicine will be able to live up to this potential that clearly excites clinicians, researchers and patients alike...
October 17, 2016: Advanced Drug Delivery Reviews
John Srbely, Brian Vadasz, Jay Shah, Naomi Lynn Gerber, Siddhartha Sikdar, Dinesh Kumbhare
No abstract text is available yet for this article.
November 2016: Clinical Journal of Pain
Feng Chen, Jun Jiang, Dan-Dan Tian, Qi Wen, Yong-Hui Li, Jun-Qing Zhang, Chen Cheng, Tengfei Wang
Cardiovascular disease still remains the primary cause of death worldwide and the obesity is becoming recognized as one of the most critical contributing risk factors. The increased prevalence of obesity casts a cloud over the global health and the whole societies will still be burdened in the future. Therefore, prevention and therapy of obesity is a beneficial strategy for the prevention of chronic cardiovascular disease. Numerous studies have demonstrated that gut microbiota takes part in human health and disease including obesity...
October 14, 2016: Current Pharmaceutical Design
Wei Yee Wan, Ahsan Mughal, Kelly Ward
Psoas abscess is commonly regarded as an unusual cause for back pains and usually associated with significant risk factors or co-morbidities. We describe the clinical presentation and findings of a young male Caucasian with bilateral psoas abscesses caused by an unusual organism, Janibacter terrae (an environmental organism) not previously described in literature and the challenges faced in managing this infection. There are very few case reports of this organism causing opportunistic infections, all reported bacteraemia mainly in patients with significant co-morbidities...
October 19, 2016: Acta Clinica Belgica
James Sapontis, Steven P Marso, David J Cohen, William Lombardi, Dimitri Karmpaliotis, Jeffrey Moses, William J Nicholson, Ashish Pershad, R Michael Wyman, Anthony Spaedy, Stephen Cook, Parag Doshi, Robert Federici, Craig R Thompson, Karen Nugent, Kensey Gosch, John A Spertus, J Aaron Grantham
BACKGROUND: Patients with chronic total occlusions of a coronary artery represent a complex, yet common, clinical conundrum among patients with ischemic heart disease. Chronic total occlusion angioplasty is increasingly being used as a treatment for these complex lesions. There is a compelling need to better quantify the safety, efficacy, benefits, and costs of the procedure. METHODS: To address these gaps in knowledge, we designed the Outcomes, Patient Health Status, and Efficiency IN Chronic Total Occlusion Hybrid Procedures (OPEN CTO) study, an investigator-initiated multicenter, single-arm registry including 12 centers with a planned enrollment of 1000 patients...
October 13, 2016: Coronary Artery Disease
Robert Jackson, Philip Cheng, Sarah Moreman, Nicola Davey, Lisa Owen
Constipation is a common and often overlooked problem, but it can cause serious complications for patients including pain, nausea, urinary retention, and prolonged hospital admission. There are no recognised criteria for the diagnosis of constipation in the acute hospital setting, and it is often the role of the ward doctor to identify and manage this problem. Completion and monitoring of "stool charts" by nursing and medical staff is key to proper recognition and management of constipation. A baseline study found that while charts were completed well, they were only monitored by doctors 17...
2016: BMJ Quality Improvement Reports
Richard X Davey
BACKGROUND: The misnamed 'vitamin' D is actually the hormone calcitriol (1,25 dihydroxyhydroxyvitamin D). It has a central regulatory role in calcium metabolism, and more widely in the immune system. The prohormone calcifediol (25 hydroxyvitamin D) is more easily measured in the laboratory and is the analyte used in reference interval formulation. Being highly lipid soluble, both calcifediol and calcitriol travel in the bloodstream on carriage proteins, principally on vitamin D binding protein, DBP...
October 13, 2016: Annals of Clinical Biochemistry
Lyndon G Amorin-Woods, Gregory F Parkin-Smith, Lee Nedkoff, Colleen Fisher
BACKGROUND: Practice-based data collection can offer insight into the nature of chiropractic practice and contribute to resolving the conundrum of the chiropractic profession's role in contemporary healthcare, subsequently informing care service policy. However, there is little formal data available about chiropractic practice to inform decision-makers about the nature and role of chiropractic within the context of a modern multidisciplinary healthcare context in Australia, particularly at a local and regional level...
2016: Chiropractic & Manual Therapies
Joanna Rorbach, Fei Gao, Christopher A Powell, Aaron D'Souza, Robert N Lightowlers, Michal Minczuk, Zofia M Chrzanowska-Lightowlers
The recent developments in cryo-EM have revolutionized our access to previously refractory structures. In particular, such studies of mammalian mitoribosomes have confirmed the absence of any 5S rRNA species and revealed the unexpected presence of a mitochondrially encoded tRNA (mt-tRNA) that usurps this position. Although the cryo-EM structures resolved the conundrum of whether mammalian mitoribosomes contain a 5S rRNA, they introduced a new dilemma: Why do human and porcine mitoribosomes integrate contrasting mt-tRNAs? Human mitoribosomes have been shown to integrate mt-tRNA(Val) compared with the porcine use of mt-tRNA(Phe) We have explored this observation further...
October 11, 2016: Proceedings of the National Academy of Sciences of the United States of America
Chang Liu, Yuanmei Ma, Yang Yang, Yuan Zheng, Jian Shang, Yusen Zhou, Shibo Jiang, Lanying Du, Jianrong Li, Fang Li
Porcine epidemic diarrhea coronavirus (PEDV) is currently devastating the US pork industry by causing 80-100% fatality rate in infected piglets. Coronavirus spike proteins mediate virus entry into cells, a process that requires the spike proteins to be proteolytically activated. It has been a conundrum what proteases activate PEDV entry. Here we systematically investigated the roles of different proteases in PEDV entry using pseudovirus entry, biochemical, and live virus infection assays. We found that PEDV spike is activated by lysosomal cysteine proteases, but not proprotein convertases or cell-surface serine proteases...
October 11, 2016: Journal of Biological Chemistry
Christoph Partes, Can Yildirim, Swen Schuster, Martin Kind, Jan W Bats, Michael Zharnikov, Andreas Terfort
A series of three homologous arene[2,3-d]-oxazole-2-thiols (benzoxazole-2-thiol (BOxSH), naphthaleneoxazole-2-thiol (NOxSH), and anthraceneoxazoline-2-thiol (AOxSH)) were deposited onto Au(111) to obtain surfaces suitable as injection layers for organic electronics. The guiding idea was that the increasingly extended conjugated system would lower the band gap of the films while the introduction of the annellated heteroaromatic ring would provide the opportunity for pseudo-symmetric attachment of the sulfur anchor, what should lower the conformational freedom of the system...
October 11, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
K Prabhath Kiran Reddy, Rajendra Prasad S
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Rajendra Kumar Agrawal, Hong-Wei Wang, Marlene Belfort
Group II introns are large catalytic RNAs that form a ribonucleoprotein (RNP) complex by binding to an intron-encoded protein (IEP). The IEP, which facilitates both RNA splicing and intron mobility, has multiple activities including reverse transcriptase. Recent structures of a group II intron RNP complex and of IEPs from diverse bacteria fuel arguments that group II introns are ancestrally related to eukaryotic spliceosomes as well as to telomerase and viruses. Furthermore, recent structural studies of various functional states of the spliceosome allow us to draw parallels between the group II intron RNP and the spliceosome...
October 11, 2016: RNA Biology
Lisa Hutchinson
No abstract text is available yet for this article.
October 11, 2016: Nature Reviews. Clinical Oncology
Lijing Liu, Fathi-Mohamed Sonbol, Bethany Huot, Yangnan Gu, John Withers, Musoki Mwimba, Jian Yao, Sheng Yang He, Xinnian Dong
It is an apparent conundrum how plants evolved effector-triggered immunity (ETI), involving programmed cell death (PCD), as a major defence mechanism against biotrophic pathogens, because ETI-associated PCD could leave them vulnerable to necrotrophic pathogens that thrive on dead host cells. Interestingly, during ETI, the normally antagonistic defence hormones, salicylic acid (SA) and jasmonic acid (JA) associated with defence against biotrophs and necrotrophs respectively, both accumulate to high levels. In this study, we made the surprising finding that JA is a positive regulator of RPS2-mediated ETI...
October 11, 2016: Nature Communications
Kaila Adia Story
Although a Black femme identity has been defined and embodied by many as an identity with Black feminist roots and revolutionary potentials, Black femmes are still rendered hypervisible and invisible through racist and heteronormative politics. Similarly, embodying a Black femme identity as a professor in academia often engenders these same pretenses of hypervisibility and invisibility. This essay explores what this existential conundrum has been for me as both a Black femme and professor of Black queer and feminist studies, while illuminating the mix of forces within academia that have attempted to stifle my chosen sexual identity and gendered performance...
October 10, 2016: Journal of Lesbian Studies
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