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https://www.readbyqxmd.com/read/28214553/mimicking-oxygen-delivery-and-waste-removal-functions-of-blood
#1
Huaifa Zhang, Jake E Barralet
In addition to immunological and wound healing cell and platelet delivery, ion stasis and nutrient supply, blood delivers oxygen to cells and tissues and removes metabolic wastes. For decades researchers have been trying to develop approaches that mimic these two immediately vital functions of blood. Oxygen is crucial for the long-term survival of tissues and cells in vertebrates. Hypoxia (oxygen deficiency) and even at times anoxia (absence of oxygen) can occur during organ preservation, organ and cell transplantation, wound healing, in tumors and engineering of tissues...
February 15, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28213294/a-low-cost-simplified-and-scaleable-pneumotachograph-and-face-mask-for-neonatal-mouse-respiratory-measurements
#2
Jenny J Sun, Roshan Nanu, Russell S Ray
INTRODUCTION: Neonatal respiratory disorders are a leading cause of perinatal mortality due to complications resulting from premature births and prenatal exposure to drugs of abuse, but optimal treatments for these symptoms are still unclear due to a variety of confounds and risk factors. Mouse models present an opportunity to study the underlying mechanisms and efficacy of potential treatments of these conditions with controlled variables. However, measuring respiration in newborn mice is difficult and commercial components are expensive and often require modification, creating a barrier and limiting our understanding of the short and long-term effects of birth complications on respiratory function...
February 15, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28202125/-effect-of-telomerase-activation-on-biological-behaviors-of-neural-stem-cells-in-rats-with-hypoxic-ischemic-insults
#3
Jun-Jie Meng, Shi-Ping Li, Feng-Yan Zhao, Yu Tong, De-Zhi Mu, Yi Qu
OBJECTIVE: To investigate the effect of telomerase activation on biological behaviors of neural stem cells after hypoxic-ischemic insults. METHODS: The neural stem cells passaged in vitro were divided into four groups: control, oxygen-glucose deprivation (OGD), OGD+cycloastragenol (CAG) high concentration (final concentration of 25 μM), and OGD+CAG low concentration (final concentration of 10 μM). The latter three groups were subjected to OGD. Telomerase reverse transcriptase (TERT) expression level was evaluated by Western blot...
February 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28174331/humidity-and-inspired-oxygen-concentration-during-high-flow-nasal-cannula-therapy-in-neonatal-and-infant-lung-models
#4
Yusuke Chikata, Saki Ohnishi, Masaji Nishimura
BACKGROUND: High-flow nasal cannula therapy (HFNC) for neonate/infants can deliver up to 10 L/min of heated and humidified gas, and FIO2 can be adjusted to between 0.21 and 1.0. With adults, humidification and actual FIO2 are known to vary according to inspiratory and HFNC gas flow, tidal volume (VT), and ambient temperature. There have been few studies focused on humidification and FIO2 in HFNC settings for neonates/infants, so we performed a bench study to investigate the influence of gas flow, ambient temperature, and respiratory parameters on humidification and actual FIO2 in a neonate/infant simulation...
February 7, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28161017/high-flow-oxygen-therapy-in-acute-bronchiolitis
#5
Steve Cunningham, Ricardo M Fernandes
No abstract text is available yet for this article.
February 1, 2017: Lancet
https://www.readbyqxmd.com/read/28161016/high-flow-warm-humidified-oxygen-versus-standard-low-flow-nasal-cannula-oxygen-for-moderate-bronchiolitis-hfwho-rct-an-open-phase-4-randomised-controlled-trial
#6
Elizabeth Kepreotes, Bruce Whitehead, John Attia, Christopher Oldmeadow, Adam Collison, Andrew Searles, Bernadette Goddard, Jodi Hilton, Mark Lee, Joerg Mattes
BACKGROUND: Bronchiolitis is the most common lung infection in infants and treatment focuses on management of respiratory distress and hypoxia. High-flow warm humidified oxygen (HFWHO) is increasingly used, but has not been rigorously studied in randomised trials. We aimed to examine whether HFWHO provided enhanced respiratory support, thereby shortening time to weaning off oxygen. METHODS: In this open, phase 4, randomised controlled trial, we recruited children aged less than 24 months with moderate bronchiolitis attending the emergency department of the John Hunter Hospital or the medical unit of the John Hunter Children's Hospital in New South Wales, Australia...
February 1, 2017: Lancet
https://www.readbyqxmd.com/read/28149597/nasal-high-flow-oxygen-therapy-after-extubation-the-road-is-open-but-don-t-drive-too-fast
#7
EDITORIAL
Antoine Rabbat, Kim Blanc, Aurélie Lefebvre, Christine Lorut
No abstract text is available yet for this article.
December 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28149541/high-flow-nasal-cannula-in-extubated-patients-is-it-advantageous-over-conventional-oxygen-therapy
#8
EDITORIAL
Jian-Jun Zhang, Bing Dai
No abstract text is available yet for this article.
December 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28124736/high-flow-nasal-cannula-hfnc-versus-nasal-continuous-positive-airway-pressure-ncpap-for-the-initial-respiratory-management-of-acute-viral-bronchiolitis-in-young-infants-a-multicenter-randomized-controlled-trial-tramontane-study
#9
Christophe Milési, Sandrine Essouri, Robin Pouyau, Jean-Michel Liet, Mickael Afanetti, Aurélie Portefaix, Julien Baleine, Sabine Durand, Clémentine Combes, Aymeric Douillard, Gilles Cambonie
PURPOSE: Nasal continuous positive airway pressure (nCPAP) is currently the gold standard for respiratory support for moderate to severe acute viral bronchiolitis (AVB). Although oxygen delivery via high flow nasal cannula (HFNC) is increasingly used, evidence of its efficacy and safety is lacking in infants. METHODS: A randomized controlled trial was performed in five pediatric intensive care units (PICUs) to compare 7 cmH2O nCPAP with 2 L/kg/min oxygen therapy administered with HFNC in infants up to 6 months old with moderate to severe AVB...
February 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28123947/nasal-high-flow-therapy-for-type-ii-respiratory-failure-in-copd-a-report-of-four-cases
#10
Ivan Pavlov, Patrice Plamondon, Stéphane Delisle
Herein we present a report of four cases of severe type II respiratory failure that had contraindications both to conventional non-invasive ventilation and to endotracheal intubation. In all four cases, we successfully used a high-flow nasal oxygen device as a rescue device, with very reassuring outcomes.
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28110612/efficacy-of-high-flow-nasal-cannula-therapy-in-intensive-care-units
#11
Timothy N Liesching, Yuxiu Lei
PURPOSE: We conducted a meta-analysis to compare the physiological and clinical outcomes of high-flow nasal cannula (HFNC) with standard oxygen (O2) or conventional noninvasive ventilation (NIV) in intensive care units (ICUs). PROCEDURES: We selected the full-text prospective studies comparing HFNC with standard O2 or NIV in ICU. The continuous variables were analyzed with sample size-adjusted pooled t test. The categorical variables were extracted and combined for recalculating odds ratio...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28095826/non-invasive-respiratory-support-for-infants-with-bronchiolitis-a-national-survey-of-practice
#12
H Turnham, R S Agbeko, J Furness, J Pappachan, A G Sutcliffe, P Ramnarayan
BACKGROUND: Bronchiolitis is a common respiratory illness of early childhood. For most children it is a mild self-limiting disease but a small number of children develop respiratory failure. Nasal continuous positive airway pressure (nCPAP) has traditionally been used to provide non-invasive respiratory support in these children, but there is little clinical trial evidence to support its use. More recently, high-flow nasal cannula therapy (HFNC) has emerged as a novel respiratory support modality...
January 17, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28089816/can-high-flow-nasal-cannula-reduce-the-rate-of-endotracheal-intubation-in-adult-patients-with-acute-respiratory-failure-compared-with-conventional-oxygen-therapy-and-noninvasive-positive-pressure-ventilation-a-systematic-review-and-meta-analysis
#13
Yue-Nan Ni, Jian Luo, He Yu, Dan Liu, Ni Zhong, Jiangli Cheng, Bin-Miao Liang, Zong-An Liang
BACKGROUND: The effects of high flow nasal cannula (HFNC) on adult patients with acute respiratory failure (ARF) are controversial. We aimed to further determine the effectiveness of HFNC in reducing the rate of endotracheal intubation in adult patients with ARF by comparison to noninvasive positive pressure ventilation (NIPPV) and conventional oxygen therapy (COT). METHODS: The Pubmed, Embase, Medline, Cochrane Central Register of Controlled Trials (CENTRAL) as well as the Information Sciences Institute (ISI) Web of Science were searched for all the controlled studies that compared HFNC with NIPPV and COT in adult patients having ARF...
January 13, 2017: Chest
https://www.readbyqxmd.com/read/28086831/evaluation-of-the-cytotoxicity-of-the-bithionol-cisplatin-combination-in-a-panel-of-human-ovarian-cancer-cell-lines
#14
Vijayalakshmi N Ayyagari, Tsung-Han Jeff Hsieh, Paula L Diaz-Sylvester, Laurent Brard
BACKGROUND: Combination drug therapy appears a promising approach to overcome drug resistance and reduce drug-related toxicities in ovarian cancer treatments. In this in vitro study, we evaluated the antitumor efficacy of cisplatin in combination with Bithionol (BT) against a panel of ovarian cancer cell lines with special focus on cisplatin-sensitive and cisplatin-resistant cell lines. The primary objectives of this study are to determine the nature of the interactions between BT and cisplatin and to understand the mechanism(s) of action of BT-cisplatin combination...
January 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28009154/high-flow-nasal-cannula-oxygen-therapy-work-in-progress-in-respiratory-critical-care
#15
Annia Schreiber, Fabiano DI Marco, Fulvio Braido, Paolo Solidoro
After a planned extubation, the re-occurrence of acute respiratory distress needing the restoration of invasive mechanical support is a severe phenomenon associated with several important consequences, including increased morbidity, Intensive Care Unit mortality, and an enormous financial burden. So far, the most commonly used techniques to ameliorate gas exchange in the postextubation period were low-flow oxygen therapy and non-invasive ventilation (NIV). High flows through nasal cannulae (HFNC) is a system which allows increased CO2 wash-out of anatomical dead space, positive nasopharyngeal pressure, a relatively constant FiO2, and an improvement of mucociliary function...
December 2016: Minerva Medica
https://www.readbyqxmd.com/read/27984228/new-innovations-in-circulatory-support-with-ventricular-assist-device-and-extracorporeal-membrane-oxygenation-therapy
#16
Robert N Sladen
The past decade has seen an exponential increase in the application and development of durable long-term as well as nondurable short-term mechanical circulatory support for cardiogenic shock and acute or chronic heart failure. Support has evolved from bridge-to-transplant to destination therapy, bridge to rescue, bridge to decision making, and bridge to a bridge. Notable trends include device miniaturization, minimally invasive and/or percutaneous insertion, and efforts to superimpose pulsatility on continuous flow...
December 15, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27977876/introducing-high-flow-nasal-cannula-to-the-neonatal-transport-environment
#17
Michael A Boyle, Arunava Dhar, Rajiv Chaudhary, Susan Kent, S Samantha O'Hare, Theodore Dassios, Susan Broster
No abstract text is available yet for this article.
December 15, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27977538/continuous-venovenous-hemofiltration-in-children-less-than-or-equal-to-10-kg-a-single-center-experience
#18
Sirée Kaempfen, Pompa Dutta-Kukreja, Quen Mok
OBJECTIVES: The aim of this study was to review the data from patients with a body weight less than or equal to 10 kg who required continuous venovenous hemofiltration, to assess the feasibility and problems associated with continuous venovenous hemofiltration in this population and compare the results with the current literature. DESIGN: Retrospective study design. SETTING: PICU in a single tertiary pediatric referral center. PATIENTS: Children less than or equal to 10 kg who received continuous venovenous hemofiltration between January 2008 and July 2014 were included in the study...
February 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/27941165/leishmania-recombinant-antigen-modulates-macrophage-effector-function-facilitating-early-clearance-of-intracellular-parasites
#19
Anuradha Ratna, Sunil K Arora
BACKGROUND: Immunmodulation combined with chemotherapy has emerged as an alternative to treat infections. The study evaluates immunomodulatory properties of a Leishmania recombinant protein (rA6) in activating macrophages and clearing intracellular parasites. METHODS: The rA6 from a previously identified cDNA clone was analyzed for inducing the production of nitric oxide (NO) and reactive oxygen species (ROS) in macrophages, post and prior to infection with promastigotes by Griess method and flow cytometry...
December 2016: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27940177/-use-of-high-flow-nasal-cannula-in-infants-with-bronchiolitis-in-a-pediatric-emergency-department
#20
M Guimaraes, M Pomedio, M Viprey, L Kanagaratnam, K Bessaci
High-flow nasal cannula oxygen therapy (HFNC) is a technique for noninvasive ventilation commonly used in pediatric intensive care units for respiratory distress, particularly in acute bronchiolitis. HFNC was introduced in the pediatric emergency department of the Reims university hospital for the treatment of infants with moderate to severe acute viral bronchiolitis. This retrospective observational study aimed to investigate the use of HFNC in a pediatric emergency ward, describing the groups of infants with acute viral bronchiolitis to be treated either with conventional oxygen therapy or with HFNC therapy...
January 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
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