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https://www.readbyqxmd.com/read/29915869/using-a-high-flow-nasal-cannula-provides-superior-results-to-oxymask-delivery-in-moderate-to-severe-bronchiolitis-a-randomized-controlled-study
#1
Ayse Betul Ergul, Emrah Calıskan, Hasan Samsa, Ikbal Gokcek, Ali Kaya, Gozde Erturk Zararsiz, Yasemin Altuner Torun
The effectiveness of using a face mask with a small diffuser for oxygen delivery (OxyMask) was compared to use of a high-flow nasal cannula (HFNC) in patients with moderate or severe bronchiolitis.The study population in this open, phase 4, randomized controlled trial consisted of 60 patients aged 1-24 months diagnosed with moderate or severe bronchiolitis and admitted to an intensive care unit (ICU) for oxygen therapy. The patients were randomized into two groups according to the method of oxygen delivery: a diffuser mask group and an HFNC group...
June 18, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29912414/peroxiredoxin-6-is-the-primary-antioxidant-enzyme-for-the-maintenance-of-viability-and-dna-integrity-in-human-spermatozoa
#2
Maria C Fernandez, Cristian O'Flaherty
STUDY QUESTION: Are all components of the peroxiredoxins (PRDXs) system important to control the levels of reactive oxygen species (ROS) to maintain viability and DNA integrity in spermatozoa? SUMMARY ANSWER: PRDX6 is the primary player of the PRDXs system for maintaining viability and DNA integrity in human spermatozoa. WHAT IS KNOWN ALREADY: Mammalian spermatozoa are sensitive to high levels of ROS and PRDXs are antioxidant enzymes proven to control the levels of ROS generated during sperm capacitation to avoid oxidative damage in the spermatozoon...
June 15, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29910540/high-flow-nasal-cannula-versus-conventional-oxygen-therapy-in-children-with-respiratory-distress
#3
Punthila Sitthikarnkha, Rujipat Samransamruajkit, Nuanchan Prapphal, Jitladda Deerojanawong, Suchada Sritippayawan
Purpose: The aim of this study is to determine the clinical efficacy of high-flow nasal cannula (HFNC) therapy compared with conventional oxygen therapy in children presented with respiratory distress. Study Design: This was a randomized controlled study. Materials and Methods: Infants and children aged between 1 month to 5 years who were admitted to our tertiary referral center for respiratory distress (July 1, 2014 to March 31, 2015) and met the inclusion criteria were recruited...
May 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29902866/disulfiram-copper-causes-ros-levels-alteration-cell-cycle-inhibition-and-apoptosis-in-acute-myeloid-leukaemia-cell-lines-with-modulation-in-the-expression-of-related-genes
#4
Saeed Hassani, Parisa Ghaffari, Bahram Chahardouli, Kamran Alimoghaddam, Ardeshir Ghavamzadeh, Shaban Alizadeh, Seyed H Ghaffari
The majority of acute myeloid leukaemia (AML) patients will die from their disease or therapy-related complications. There is an inevitable need to improve the survival of AML patients. Previous studies show that disulfiram (DSF), an anti-alcoholism drug with a low toxicity profile, demonstrates anticancer behaviors. Here, we evaluated the cytotoxicity and mechanistic action of DSF on the AML cell lines KG-1, NB4, and U937. The microculture tetrazolium test revealed that DSF alone or in combination with copper (Cu) is highly toxic to the AML cells at concentrations lower than those achievable in the clinical setting, with Cu increasing the DSF-induced inhibition of metabolic activity...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29892198/novel-quinazoline-based-sulfonamide-derivative-3d-induces-apoptosis-in-colorectal-cancer-by-inhibiting-jak2-stat3-pathway
#5
Omar Al-Obeed, Mansoor-Ali Vaali-Mohammed, Wagdy M Eldehna, Khayal Al-Khayal, Amer Mahmood, Hatem A Abdel-Aziz, Ahmed Zubaidi, Ahmed Alafeefy, Maha Abdulla, Rehan Ahmad
Introduction: Colorectal cancer (CRC) is a major worldwide health problem owing to its high prevalence and mortality rate. Developments in screening, prevention, biomarker, personalized therapies and chemotherapy have improved detection and treatment. However, despite these advances, many patients with advanced metastatic tumors still succumb to the disease. New anticancer agents are needed for treating advanced stage CRC as most of the deaths occur due to cancer metastasis. A recently developed novel sulfonamide derivative 4-((2-(4-(dimethylamino) phenyl)quinazolin-4-yl)amino)benzenesulfonamide (3D) has shown potent antitumor effect; however, the mechanism underlying the antitumor effect remains unknown...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29890848/inhaled-epoprostenol-through-noninvasive-routes-of-ventilator-support-systems
#6
Mahmoud A Ammar, Madhu Sasidhar, Simon W Lam
BACKGROUND: The administration of inhaled epoprostenol (iEPO) through noninvasive routes of ventilator support systems has never been previously evaluated. OBJECTIVE: Describe the use of iEPO when administered through noninvasive routes of ventilator support systems. METHODS: Critically ill patients admitted to the intensive care unit who received iEPO through noninvasive routes were analyzed. Improvements in respiratory status and hemodynamic parameters were evaluated...
June 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29884181/the-therapeutic-effect-of-mesenchymal-stem-cells-on-pulmonary-myeloid-cells-following-neonatal-hyperoxic-lung-injury-in-mice
#7
Ali Al-Rubaie, Andrea F Wise, Foula Sozo, Robert De Matteo, Chrishan S Samuel, Richard Harding, Sharon D Ricardo
BACKGROUND: Exposure to high levels of oxygen (hyperoxia) after birth leads to lung injury. Our aims were to investigate the modulation of myeloid cell sub-populations and the reduction of fibrosis in the lungs following administration of human mesenchymal stem cells (hMSC) to neonatal mice exposed to hyperoxia. METHOD: Newborn mice were exposed to 90% O2 (hyperoxia) or 21% O2 (normoxia) from postnatal days 0-4. A sub-group of hyperoxia mice were injected intratracheally with 2...
June 8, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29880331/clinical-outcomes-of-oxygen-therapy-using-high-flow-nasal-cannula-in-japan
#8
EDITORIAL
Makoto Hasegawa
No abstract text is available yet for this article.
June 4, 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29802651/using-high-flow-nasal-cannulas-for-infants-with-bronchiolitis-admitted-to-paediatric-wards-is-safe-and-feasible
#9
Paula Heikkilä, Paula Sokuri, Minna Mecklin, Kirsi Nuolivirta, Terhi Tapiainen, Outi Peltoniemi, Marjo Renko, Matti Korppi
AIM: Using a high-flow nasal cannula (HFNC) for infant bronchiolitis is increasingly common, but insufficiently studied. In this retrospective study, we examined the outcomes of HFNC and compared infants who did and did not respond to this oxygen delivery method. METHODS: This 2012-2015 study of six Finnish hospitals focused on 88 infants under 12 months who received HFNC: 53 on paediatric wards and 35 in paediatric intensive care units (PICUs). We reviewed patient files for underlying factors, clinical parameters and HFNC treatment...
May 26, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29796561/a-multiplexed-microfluidic-system-for-evaluation-of-dynamics-of-immune-tumor-interactions
#10
N Moore, D Doty, M Zielstorff, I Kariv, L Y Moy, A Gimbel, J R Chevillet, N Lowry, J Santos, V Mott, L Kratchman, T Lau, G Addona, H Chen, J T Borenstein
Recapitulation of the tumor microenvironment is critical for probing mechanisms involved in cancer, and for evaluating the tumor-killing potential of chemotherapeutic agents, targeted therapies and immunotherapies. Microfluidic devices have emerged as valuable tools for both mechanistic studies and for preclinical evaluation of therapeutic agents, due to their ability to precisely control drug concentrations and gradients of oxygen and other species in a scalable and potentially high throughput manner. Most existing in vitro microfluidic cancer models are comprised of cultured cancer cells embedded in a physiologically relevant matrix, collocated with vascular-like structures...
May 25, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29773297/the-clinical-practice-of-high-flow-nasal-cannula-oxygen-therapy-in-adults-a-japanese-cross-sectional-multicenter-survey
#11
Jiro Ito, Kazuma Nagata, Susumu Sato, Akira Shiraki, Naoki Nishimura, Shinyu Izumi, Ryo Tachikawa, Takeshi Morimoto, Keisuke Tomii
BACKGROUND: High-flow nasal cannula oxygen therapy (HFNC) is widely used mainly in the acute care setting, but limited data are available on real-world practice in adults. The objective of this study was to describe HFNC practices in Japanese adults. METHODS: A retrospective cross-sectional multicenter survey of adult patients receiving HFNC from January through March 2015 was conducted in 33 participating hospitals in Japan. RESULTS: We obtained information on 321 patients (median age, 76; 218 men, 103 women; median estimated PaO2 /FI O2, 178 mm Hg) from 22 hospitals...
May 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29764401/management-of-acute-respiratory-failure-in-interstitial-lung-diseases-overview-and-clinical-insights
#12
REVIEW
Paola Faverio, Federica De Giacomi, Luca Sardella, Giuseppe Fiorentino, Mauro Carone, Francesco Salerno, Jousel Ora, Paola Rogliani, Giulia Pellegrino, Giuseppe Francesco Sferrazza Papa, Francesco Bini, Bruno Dino Bodini, Grazia Messinesi, Alberto Pesci, Antonio Esquinas
BACKGROUND: Interstitial lung diseases (ILDs) are a heterogeneous group of diseases characterized by widespread fibrotic and inflammatory abnormalities of the lung. Respiratory failure is a common complication in advanced stages or following acute worsening of the underlying disease. Aim of this review is to evaluate the current evidence in determining the best management of acute respiratory failure (ARF) in ILDs. METHODS: A literature search was performed in the Medline/PubMed and EMBASE databases to identify studies that investigated the management of ARF in ILDs (the last search was conducted on November 2017)...
May 15, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29761012/an-overview-of-protective-strategies-against-ischemia-reperfusion-injury-the-role-of-hyperbaric-oxygen-preconditioning
#13
Ciprian Hentia, Alex Rizzato, Enrico Camporesi, Zhongjin Yang, Danina M Muntean, Dorel Săndesc, Gerardo Bosco
Introduction: Ischemia/reperfusion (I/R) injury, such as myocardial infarction, stroke, and peripheral vascular disease, has been recognized as the most frequent causes of devastating disorders and death currently. Protective effect of various preconditioning stimuli, including hyperbaric oxygen (HBO), has been proposed in the management of I/R. Methods: In this study, we searched and reviewed up-to-date published papers to explore the pathophysiology of I/R injury and to understand the mechanisms underlying the protective effect of HBO as conditioning strategy...
May 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29750833/high-flow-oxygen-therapy-is-safe-and-effective-in-infants-with-bronchiolitis
#14
EDITORIAL
Matti Korppi, Terhi Tapiainen
No abstract text is available yet for this article.
May 11, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29746214/a-two-component-assay-for-hypoxia-incorporating-long-term-nitroreduction-and-short-term-dna-damage-allows-differentiation-of-the-three-hypoxia-sub-types
#15
Cameron J Koch
Hypoxia in tumors has many well-characterized effects that are known to prevent optimal cancer treatment. Despite the existence of a large number of assays that have supported hypoxia as an important diagnostic, there is no routine clinical assay in use, and anti-hypoxia therapies have often not included parallel hypoxia measurements. Even with a functioning hypoxia assay, it is difficult to match the oxygen dependence of treatment resistance to that of the assay, and this mismatch can vary substantially from assay to assay and even from tumor to tumor [e...
May 10, 2018: Radiation Research
https://www.readbyqxmd.com/read/29719796/use-of-high-flow-nasal-cannula-in-obese-patients-receiving-colonoscopy-under-intravenous-propofol-sedation-a-case-series
#16
Chi Chan Lee, Osman Perez, Faryal I Farooqi, Trupti Akella, Sameer Shaharyar, Melissa Elizee
Intravenous sedation during colonoscopy has become the standard practice in the United States given its higher patient satisfaction and procedural quality. This practice is not free of side effects as a significant proportion of patients undergoing this procedure tend to have respiratory depression and desaturation events. Obesity, as it relates to higher levels of body mass index (BMI) has a positive correlation with the incidence of hypoxemia. During colonoscopy High flow nasal cannula (HFNC) may potentially improve oxygen performance in patients receiving colonoscopy under intravenous sedation...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29713153/long-term-effects-of-oxygen-enriched-high-flow-nasal-cannula-treatment-in-copd-patients-with-chronic-hypoxemic-respiratory-failure
#17
Line Hust Storgaard, Hans-Ulrich Hockey, Birgitte Schantz Laursen, Ulla Møller Weinreich
Background: This study investigated the long-term effects of humidified high-flow nasal cannula (HFNC) in COPD patients with chronic hypoxemic respiratory failure treated with long-term oxygen therapy (LTOT). Patients and methods: A total of 200 patients were randomized into usual care ± HFNC. At inclusion, acute exacerbation of COPD (AECOPD) and hospital admissions 1 year before inclusion, modified Medical Research Council (mMRC) score, St George's Respiratory Questionnaire (SGRQ), forced expiratory volume in 1 second (FEV1 ), 6-minute walk test (6MWT) and arterial carbon dioxide (PaCO2 ) were recorded...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29694995/respiratory-support-in-bronchiolitis-trial-evidence
#18
Steve Cunningham
Acute viral lower respiratory tract infection is frequently associated with hypoxemia and respiratory distress, sometimes progressing to hypercarbia and respiratory failure. In recent years, trials have assessed the effects of oxygen supplementation and respiratory support with high-flow oxygen therapy. An oxygen saturation target of 90% is as safe and clinically effective as 94% in infants with bronchiolitis. Trials of high-flow humidified oxygen have demonstrated safety, but as yet poorly demarcated an appropriate place for use within the clinical course of the disease...
May 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29685370/is-high-flow-nasal-cannula-more-effective-than-conventional-oxygen-therapy-for-preventing-escalation-of-respiratory-support-in-patients-with-acute-respiratory-failure
#19
EDITORIAL
Brit Long, Michael D April
No abstract text is available yet for this article.
April 20, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29683293/psoriasis-as-a-cardiovascular-risk-factor-updates-and-algorithmic-approach
#20
Emanuele Cozzani, Gianmarco Rosa, Martina Burlando, Aurora Parodi
Although psoriasis is predominantly a chronic inflammatory skin disorder, it has been known to be associated with cardiovascular disease. Patients with psoriasis, particularly with moderate to severe forms, present an increased rate of cardiovascular mortality, myocardial infarction and stroke. However the pathophysiology of the relationship between psoriasis and cardiovascular risk and comorbidities has not yet completely known. Chronic inflammation may be considered a solid link between psoriasis and related cardiovascular events...
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
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