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https://www.readbyqxmd.com/read/28203167/metastasis-of-colon-cancer-to-the-breast
#1
Swei H Tsung
Breast metastases from extramammary neoplasms are extremely rare, and even more so is metastasis of colon cancer to the breast. Despite its rarity, metastatic disease to the breast is an important diagnostic issue because its treatment differs greatly from that of primary cancer. Proper diagnosis of this rare event requires an accurate clinical history, proper immunohistochemical workup, and a high level of suspicion.
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28178005/surgical-treatment-and-outcomes-of-patients-with-extramammary-paget-disease-a-cohort-study
#2
Sharon J Kim, Agnieszka K Thompson, Adeel S Zubair, Clark C Otley, Christopher J Arpey, Christian L Baum, Randall K Roenigk, Christine M Lohse, Jerry D Brewer
BACKGROUND: Extramammary Paget disease (EMPD) is a rare intraepithelial adenocarcinoma occurring mainly in the anogenital region. Traditional management with wide local excision has shown high recurrence rates, thus Mohs micrographic surgery (MMS) has emerged as a promising treatment option. OBJECTIVE: To compare long-term outcomes after treatment with MMS or excision for primary EMPD. METHODS AND MATERIALS: Retrospective cohort review was conducted for 207 patients with EMPD treated at Mayo Clinic in Rochester, MN, between 1961 and 2012...
February 6, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28166615/successful-use-of-radiotherapy-in-the-treatment-of-extramammary-paget-s-disease-in-vulvar-area
#3
Antonella Tammaro, Veronica Giulianelli, Irene Romano, Eleonora DE Vito, Francesca R Parisella, Maria Giubettini, Severino Persechino
No abstract text is available yet for this article.
April 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28150330/serum-cytokeratin-19-fragment-21-1-is-a-useful-tumor-marker-for-the-assessment-of-extramammary-paget-s-disease
#4
Junji Kato, Yasuyuki Sumikawa, Tokimasa Hida, Takafumi Kamiya, Kohei Horimoto, Shiori Kamiya, Sayuri Sato, Hitomi Takahashi, Masahide Sawada, Toshiharu Yamashita
Cytokeratin 19 fragment 21-1 (CYFRA 21-1) has been used as a tumor marker for several malignancies. However, to date, no studies have assessed whether CYFRA 21-1 could be a useful marker for extramammary Paget's disease (EMPD). The present study aimed to evaluate the significance of CYFRA 21-1 as a serum tumor marker for EMPD progression. Concentrations of serum CYFRA 21-1 and carcinoembryonic antigen (CEA) in 13 cases of EMPD were measured prior to undergoing treatment at Sapporo Medical University Hospital from January 2014 to May 2016...
February 2, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28107259/paget-s-disease-of-the-vulva-a-review-of-20-years-experience
#5
Raghava Parashurama, Vivek Nama, Richard Hutson
BACKGROUND: Extramammary Paget's disease is a rare condition, and the vulva is a common site for it to occur. Despite this, there is a paucity of literature on Paget's disease of the vulva (VPD). A Cochrane meta-analysis could not draw any conclusions on interventions in VPD. Our aim was to review our practice and improve further management of VPD in our center. METHODS: We reviewed all the cases presented to Leeds Gynaecological Oncology Centre between 1988 and 2016...
January 19, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28098399/myb-cd117-and-sox-10-expression-in-cutaneous-adnexal-tumors
#6
Mara Therese P Evangelista, Jeffrey P North
BACKGROUND: Elevated MYB expression has been documented in adenoid cystic carcinoma (ACC), cylindroma, and spiradenoma, but the specificity of this finding is unknown. CD117 and SOX-10 expression also occurs in some cutaneous adnexal tumors. This study assesses MYB, CD117, and SOX-10 expression in cutaneous adnexal tumors. METHODS: Retrospective analysis of 184 benign adnexal tumors (140 eccrine/apocrine, 40 follicular, and 10 sebaceous), and 30 malignant adnexal tumors was performed with MYB, SOX-10, and CD117 immunostaining...
January 18, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28076009/delineating-extramammary-findings-at-breast-mr-imaging
#7
Yiming Gao, Opeyemi Ibidapo, Hildegard K Toth, Linda Moy
Breast magnetic resonance (MR) imaging is the only breast imaging modality that consistently encompasses extramammary structures in the thorax and upper abdomen. Incidental extramammary findings on breast MR images of patients with a history of breast cancer or other malignancies are significantly more likely to be malignant and may affect staging and treatment. An understanding of the frequency, distribution, and context of extramammary findings on breast MR images and a familiarity with common and uncommon sites of breast cancer metastasis inform the differential diagnosis and prompt the appropriate diagnostic next step, to differentiate benign from malignant findings...
January 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28058078/extramammary-paget-s-disease-of-anal-canal-associated-with-rectal-adenoma-without-invasive-carcinoma
#8
Vaibhav Chumbalkar, Timothy A Jennings, Sanaz Ainechi, Edward C Lee, Hwajeong Lee
Extramammary Paget's disease (EMPD) is a rare disease which is found in apocrine-rich locations such as anogenital region, axilla and rarely in other sites. Perianal EMPD is often reported as the involvement of perianal skin, but involvement of anal mucosa is very rare. Based on pathogenesis and association with either synchronous or metachronous malignancy, EMPD can be divided into primary and secondary types. Treatment approach for these two types of Paget's disease and their prognosis is different, thus it is important to make the distinction...
December 2016: Gastroenterology Research
https://www.readbyqxmd.com/read/28052404/perineal-reconstruction-with-multiple-perforator-flaps-based-on-anatomical-divisions
#9
Joon P Hong, Chang G Kim, Hyun S Suh, Hoon Kim, Chi S Yoon, Kyu N Kim
PURPOSE: Reconstruction of perineal defects remains a challenge because such defects can be extensive, complex, and three-dimensional. This report presents a retrospective review of our past 5 years of experience in perineal reconstruction, and suggests a simple algorithmic approach according to anatomical divisions with multiple pedicled perforator flaps for extensive perineal defects. METHODS: From January 2011 to December 2015, 16 patients, including 5 men and 11 women, underwent reconstruction of extensive perineal defects...
January 4, 2017: Microsurgery
https://www.readbyqxmd.com/read/28028810/three-dimensional-evaluation-of-subclinical-extension-of-extramammary-paget-s-disease-visualization-of-histological-border-and-its-comparison-to-clinical-border
#10
T Murata, T Honda, G Egawa, A Kitoh, T Dainichi, A Otsuka, S Nakajima, S Kore-Eda, Y Kaku, S Nakamizo, Y Endo, A Fujisawa, Y Miyachi, K Kabashima
BACKGROUND: In extramammary Paget's disease (EMPD), Paget cells are sometimes detected outside the clinical border (subclinical extension). The spreading pattern of Paget cells in subclinical extension, however, remains unclear. In addition, the macroscopic appearances of lesions accompanied by subclinical extension are totally unknown. OBJECTIVES: To characterize the spreading pattern of Paget cells as well as the macroscopic appearance of lesions of EMPD with subclinical extension...
December 27, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27994832/mayo-clinic-cancer-center-experience-of-metastatic-extramammary-paget-disease-1998-2012
#11
Leslie Padrnos, Nina Karlin, Thorvardur R Halfdanarson
Extramammary Paget disease (EMPD) is a rare cutaneous malignancy. The most common presentation of EMPD is the vulva followed by perianal involvement. Most cases are localized to the dermis with treatment focused on surgery, topical treatment or radiotherapy. Recurrence is frequent despite therapies utilized. Metastatic extramammary Paget disease is uncommon and, as such, standard treatment guidelines do not exist. This study sought to evaluate the treatment regimens and outcomes of patients treated at a Mayo Clinic Center from 1998-2012...
November 17, 2016: Rare Tumors
https://www.readbyqxmd.com/read/27976423/mohs-micrographic-surgery-of-rare-cutaneous-tumors
#12
Sophie C Flohil, Charlotte B van Lee, Jessica Beisenherz, Marc A M Mureau, Lucy I H Overbeek, Tamar Nijsten, Renate R van den Bos
BACKGROUND: Recurrence rates after Mohs micrographic surgery (MMS) for rare cutaneous tumors are poorly defined. OBJECTIVE: Investigate the recurrence rate after MMS for rare cutaneous tumors at a university center. METHODS & MATERIALS: Retrospective review of all rare cutaneous tumors treated with MMS at a large university center between January 2008 and December 2012. To detect all recurrences, patients were linked to The nationwide network and registry of histo- and cytopathology (PALGA)...
December 15, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27832673/extramammary-paget-disease-of-the-vulva-case-report
#13
Bianca Ruschel Hillmann, Amanda Amaro Pereira, Luiz Fernando Sommacal
Extramammary Paget disease (EPD) is a rare malign neoplasm that may affect the vulva and has manifestations common to benign diseases such as itching, pain and eczema. This leads to delay in diagnosis and consequent worse prognosis. The definitive diagnosis is obtained by biopsy of the vulva, which shows Paget cells. The treatment of choice is wide excision with margins, which leads to sequelae, functional and aesthetic. Recurrence is common. This article reports the case of a 48-year-old female patient with history of vulvar itching for the past 2 years, who had been submitted to various treatments for benign pathologies...
October 2016: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/27793323/extramammary-findings-in-diagnostic-breast-magnetic-resonance-imaging-among-patients-with-known-breast-cancer-incidence-and-cost-analysis
#14
Lisa M Hayes, Julia S Frebault, Jeffrey Landercasper, Andrew J Borgert, Choua A Vang, Jeanne M Johnson, Jared H Linebarger
BACKGROUND: Extramammary findings (EMFs) are common on breast magnetic resonance imaging (MRI). METHODS: A retrospective review of breast MRIs in breast cancer patients between January 2009 and December 2014 was performed to identify EMF occurrences, resultant evaluation, and added cost. RESULTS: EMFs were noted in 185 (59%) of 316 MRIs. Overall, 201 new EMFs were identified with 178 (89%) benign and 23 (11%) malignant. New malignant findings included 19 metastatic nodes (18 axillary, 1 internal mammary) and 4 primary malignancies (2 thyroid, 2 lung)...
December 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27772880/primary-invasive-extramammary-paget-s-disease-on-penoscrotum-a-clinicopathological-analysis-of-41-cases
#15
Yunyi Kong, Xuxia Shen, Jiaojie Lv, Bo Shu
No abstract text is available yet for this article.
February 2016: Pathology
https://www.readbyqxmd.com/read/27766674/cutaneous-metastasis-of-inflammatory-breast-carcinoma-mimicking-an-erythema-annulare-centrifugum-a-sign-of-locally-recurrent-cancer
#16
V Sabater, F Ferrando, A Morera, L Palomar
Erythema annulare centrifugum (EAC) is a clinical reaction pattern that includes lupus erythematosus, spongiotic dermatitis (particularly pityriasis rosea), pseudolymphoma and cutaneous B-cell lymphoma. However, it can be the result of cutaneous metastasis by an internal carcinoma. We present the case of a 38-year-old woman with bilateral inflammatory breast cancer following multimodal therapy. After chemotherapy, the patient developed EAC on her back, clinically suspect of subacute cutaneous lupus erythematosus...
December 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27761174/spinal-metastases-of-extramammary-paget-disease-with-radiologic-pathologic-correlation
#17
Jason T Little, Vance T Lehman, Jonathan M Morris, Julia S Lehman, Felix E Diehn
Extramammary Paget disease (EMPD) is an uncommon malignancy. It manifests either in the primary form in the skin as an intraepithelial neoplasm, or in secondary form as pagetoid (intraepithelial) spread of an underlying internal carcinoma to the skin. Although local invasion and recurrence of primary extramammary Paget disease are relatively frequent, widespread metastases are rare. As such, there are very few reports and little characterization of the radiologic features of widespread spinal metastases. To our knowledge, there are no prior reports of a metastatic extramammary Paget disease presenting as a painful pathologic vertebral body compression fracture...
May 2016: Journal of Radiology Case Reports
https://www.readbyqxmd.com/read/27746643/perianal-and-vulvar-extramammary-paget-disease-a-report-of-six-cases-and-mapping-biopsy-of-the-anal-canal
#18
Yuzo Nagai, Sinsuke Kazama, Daisuke Yamada, Takuya Miyagawa, Koji Murono, Koji Yasuda, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Kazushige Kawai, Yuri Masui, Hiroaki Nozawa, Hironori Yamaguchi, Soichiro Ishihara, Takafumi Kadono, Toshiaki Watanabe
Treatment of perianal and vulvar extramammary Paget disease (EMPD), rare intraepithelial malignancies, is often challenging because of its potential to spread into the anal canal. However, there is still no consensus regarding the optimal resection margin within the anal canal. Between 2004 and 2014, six patients (three with perianal EMPD and three with vulvar EMPD) in which the spread of Paget cells into the anal canal was highly suspected were referred to our department. To evaluate the disease extent within the anal canal, preoperative mapping biopsy of the anal canal was performed in five out of six patients...
October 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27717438/preneoplastic-and-primary-scrotal-cancer-updates-on-pathogenesis-and-diagnostic-evaluation
#19
REVIEW
Yao Zhu, Ding-Wei Ye
Occupational exposure has been causally linked to scrotal cancer. Primary preventative care and avoiding carcinogenic substances have decreased the incidence and changed the treatment of scrotal cancer. The current incidence of scrotal malignancy is approximately 1 per 1,000,000 male persons/year. The rarity of cases and of research impedes our understanding of the changing nature of scrotal cancer. This article summarizes the current knowledge, focusing mainly on pathogenesis and diagnostic evaluation, which may influence prevention and early recognition of the disease...
November 2016: Urologic Clinics of North America
https://www.readbyqxmd.com/read/27689055/three-directional-reconstruction-of-a-massive-perineal-defect-after-wide-local-excision-of-extramammary-paget-s-disease
#20
Seung Woo Cho, Hak Chang, Sung Tack Kwon
Extramammary Paget's disease (EMPD) is a rare, slow-growing intraepithelial malignancy that mainly involves the genital region, including the vulva, penis, scrotum, perianal, and periurethral areas. Although several treatment options exist, wide local excision with a safe margin is considered the treatment of choice. After resection of the lesion, it is often challenging to reconstruct the defect because defects in the perineal region require adequate volume for protection and are susceptible to infections, which is a particularly significant risk for large defects...
September 2016: Archives of Plastic Surgery
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