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https://www.readbyqxmd.com/read/29766708/axillary-extramammary-paget-s-disease-on-lymphadenectomy-scar-for-melanoma-an-instance-of-immunocompromised-district
#1
Roberta Giuffrida, Francesco Borgia, Maria Lentini, Roberta Cardia, Serafinella P Cannavò
No abstract text is available yet for this article.
June 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29763511/a-review-of-non-invasive-imaging-in-extramammary-paget-s-disease
#2
REVIEW
Claire-Audrey Y Bayan, Trisha Khanna, Veronica Rotemberg, Faramarz H Samie, Nathalie C Zeitouni
Extramammary Paget's Disease (EMPD) is a rare intraepithelial adenocarcinoma that classically manifests with pruritic, erythematous, scaling plaques. The clinical picture frequently mimics inflammatory or infectious conditions, and is thus commonly misdiagnosed. The assessment of tumor margins is equally challenging as tumors have a propensity to spread beyond clinically visible boundaries. Appropriate non-invasive diagnostic tools can assist in the early detection, diagnosis, and management of EMPD. This paper will review the literature on non-invasive imaging modalities used in EMPD...
May 15, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29763492/perianal-extramammary-paget-disease-treated-with-topical-imiquimod-and-oral-cimetidine
#3
Jayla Gray, Arielle Gray, James Swan, Joshua Eberhardt, Kumaran Mudaliar, Rebecca Tung
Extramammary Paget disease (EMPD) is a rare intraepithelial adenocarcinoma. The current mainstay of treatment is wide local excision. We present the case of a 56-year-old woman with perianal EMPD that recurred 4 years after initial treatment with wide local excision with Mohs micrographic surgery tissue processing of marginal tissue. Upon recurrence with anal canal involvement, the patient was treated with a 16-week combination course of topical imiquimod and oral cimetidine. There is growing evidence to support both the use of topical imiquimod for the treatment of EMPD as well as the antioncogenic effects of oral cimetidine...
April 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29761691/extramammary-paget-disease-of-the-penis-closely-mimicking-the-penile-analogue-of-stratified-mucin-producing-intraepithelial-lesion-smile
#4
Alessia Cimadamore, Marina Scarpelli, Liang Cheng, Antonio Lopez-Beltran, Rodolfo Montironi
No abstract text is available yet for this article.
May 14, 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29745285/p16-expression-in-extramammary-paget-s-disease-of-the-vulva-and-scrotum-is-not-human-papillomavirus-related
#5
Khaleel I Al-Obaidy, Chia-Sui Kao, Muhammad T Idrees
INTRODUCTION: Extramammary Paget disease (EMPD) of the vulva has been shown to express p16 by immunohistochemistry (IHC), however, p16 expression in the vulva and scrotum has not been extensively studied in relation to human papillomavirus (HPV) within EMPD of both the vulva and scrotum. DESIGN: Twenty-two cases of EMPD (vulva, 16; scrotum, 6) were found in our laboratory information system. P16 and HPV IHC were performed. Any p16 reactivity less than 10% was considered negative...
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29744813/assessment-of-the-methods-used-to-detect-her2-positive-advanced-extramammary-paget-s-disease
#6
Ikuko Hirai, Keiji Tanese, Yoshio Nakamura, Atsushi Otsuka, Yasuhiro Fujisawa, Yuki Yamamoto, Hiroo Hata, Taku Fujimura, Shigeto Matsushita, Koji Yoshino, Kaori Kameyama, Masayuki Amagai, Takeru Funakoshi
The human epidermal growth factor receptor 2 (HER2) is recognized as an oncogene as well as a therapeutic target in various cancers. Certain patients with advanced extramammary Paget's disease (EMPD) have also been reported to express HER2, which is therefore considered a therapeutic target for EMPD. However, an accurate methodology to determine HER2-positive EMPD has not been established. To assess the optimal methods for detection of HER2-positive EMPD, 73 EMPD samples were analyzed by immunohistochemical (IHC) staining, fluorescence in situ hybridization (FISH), and the HER2 testing algorithm for breast cancer of the American Society of Clinical Oncology/College of American Pathologists, which combined the results of IHC staining and FISH...
May 9, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29727346/imaging-features-of-extramammary-paget-disease-of-the-scrotum-a-case-report
#7
Sang Lim Choi, Sung Bin Park, Eun Sun Lee, Hyun Jeong Park, Jong Beum Lee, Byung Ihn Choi
Extramammary Paget disease (EMPD) is a rare intraepithelial malignancy originating in areas rich in apocrine glands, such as the vulva, perineum, perianal area, scrotum, and penis. A few reports of EMPD involving the scrotum have been described in the literature. However, only few reports have described imaging features observed in patients presenting with EMPD. We report EMPD in a patient showing scrotal involvement, focusing on imaging features, particularly those determined ultrasonographically.
January 5, 2018: Ultrasound Quarterly
https://www.readbyqxmd.com/read/29725859/surgical-treatment-for-extramammary-paget-s-disease
#8
REVIEW
Uwe Wollina, Alberto Goldman, Andrzej Bieneck, Mohamed Badawy Abdel-Naser, Sven Petersen
Extramammary Paget's disease (EMPD) is a rare, slow growing non-melanoma skin cancer.Diagnosis is often significantly delayed, since clinical presentation may resemble common benign dermatoses. Treatment is characterized by high recurrence rates. This is in part due to ill-defined margins and by frequent development of satellites. Improvement of outcome needs a better preoperative planning with fluorescence diagnostics or scouting biopsies. Mohs micrographic surgery has some advantages for patients, such as reduced relapse rates and prolonged relapse-free survival...
May 3, 2018: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29696480/perianal-extramammary-paget-s-disease-more-than-meets-the-eye
#9
Jeff Choi, Allison Zemek, Gordon K Lee, Cindy Kin
No abstract text is available yet for this article.
April 26, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29691588/serum-carcinoembryonic-antigen-level-as-a-marker-for-advanced-stage-and-chemotherapeutic-response-in-extramammary-paget-s-disease
#10
Hiroshi Umemura, Osamu Yamasaki, Tatsuya Kaji, Masaki Otsuka, Kenji Asagoe, Keiji Iwatsuki
No abstract text is available yet for this article.
April 24, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29685612/docetaxel-combined-with-cisplatin-for-metastatic-extramammary-paget-disease
#11
Hongzhou Cai, Weizhang Xu, Bin Yu, Xiao Li, Liangjun Zhu, Zicheng Xu, Jin Zhou, Yuxiao Zheng, Qing Zou, Yun Zeng, Xinwei Wang, Ting Xu
INTRODUCTION: Metastatic extramammary Paget disease (EMPD) as a rare intraepithelial carcinoma is fatal. However, no standardized chemotherapy has been established. We provided docetaxel combined with cisplatin to EMPD patients. PATIENTS AND METHODS: A total of 8 patients with metastatic EMPD were included in this study between July 2010 and July 2015 (mean age, 64.4 years); they underwent a mean of 9.4 cycles of chemotherapy. All the patients were treated with chemotherapy (docetaxel 60 mg/m2 on day 1; cisplatin 25 mg/m2 on days 1-3) as first-line treatment for > 6 cycle (at least 21 days per cycle)...
March 23, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29627436/ala-pdt-as-palliative-care-in-a-patient-with-secondary-perineum-empd
#12
Shuzhan Shen, Guolong Zhang, Peiru Wang, Yunfeng Zhang, Uma Keyal, Jie Ji, Xiuli Wang
Extramammary Paget's disease (EMPD) is a rare intraepithelial neoplasm arising in apocrine rich area of the skin. It is divided into primary and secondary EMPD based on whether there is an underlying malignancy, either local apocrine cancers or distant neoplasms. Therefore, all patients with EMPD should undergo an extensive and targeted cancer workup, depending on the histological staining pattern and the location. Surgical removal is considered the mainstay of treatment for patients with EMPD. Herein, we present a case of secondary EMPD where photodynamic therapy was effective in terms of improving symptoms and quality of life...
April 5, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29606821/pagetoid-bowen-disease-initially-misdiagnosed-as-ectopic-extramammary-paget-s-disease
#13
Jaewon Lee, Minwoo Kim, Jungyoon Moon, Hyun-Sun Yoon, Soyun Cho, Hyun-Sun Park
Pagetoid Bowen disease is a histological variant of Bowen disease which demonstrates large pale staining cells (pagetoid cells). It requires differential diagnosis from other cutaneous malignancies with similar patterns, such as extramammary Paget's disease (EMPD) and Pagetoid melanoma in situ . Herein, we report a case of Pagetoid Bowen disease which was initially misdiagnosed as ectopic EMPD.
April 2018: Annals of Dermatology
https://www.readbyqxmd.com/read/29575944/the-diagnosis-and-management-of-extramammary-paget-s-disease
#14
Takamichi Ito, Yumiko Kaku-Ito, Masutaka Furue
Extramammary Paget's disease (EMPD) is a rare neoplastic condition that commonly affects the anogenital area in the elderly. Owing to its low incidence, limited data regarding EMPD's diagnosis and treatment have been available. This review article aims to explore the current knowledge of EMPD to improve the management of this disease. Areas covered: This review outlines the diagnosis and management of EMPD. Articles on this issue that had been published in PubMed were identified and surveyed. We provide an overview of the reported studies, focusing on the recent advances in this field...
March 27, 2018: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29569629/corrigendum-metastatic-extramammary-paget-s-disease-pathogenesis-and-novel-therapeutic-approach
#15
Keitaro Fukuda, Takeru Funakoshi
[This corrects the article on p. 38 in vol. 8, PMID: 29503810.].
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29566925/genital-diseases-in-the-mature-woman
#16
Natalie Matthews, Vivian Wong, Joe Brooks, George Kroumpouzos
Vulvovaginal conditions are common in mature women. This reflects age-related changes in immunity and skin barrier function of vulvovaginal tissues. Vaginal atrophy is commonly complicated by dryness and inflammation, which makes postmenopausal atrophic vaginitis a virtually ubiquitous condition. The differential of vaginitis includes inflammatory, infectious, and malignant diseases, plus drug hypersensitivity. Atrophic vaginitis is treated with estrogen replacement therapy. Vulvovaginal malignant melanoma occurs predominantly in postmenopausal women and carries a poor prognosis...
March 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29549911/impact-of-breast-mri-in-women-eligible-for-breast-conservation-surgery-and-intra-operative-radiation-therapy
#17
Nitika Paudel, Kevin P Bethke, Lilian C Wang, Jonathan B Strauss, John P Hayes, Eric D Donnelly
PURPOSE: The current standard of care for women diagnosed with early stage breast cancer is breast-conserving surgery (BCS) followed by external beam radiation therapy, commonly delivered over 3-6 weeks. As an alternative, select patients can undergo intra-operative radiation therapy (IORT) at the time of BCT. This technique delivers a single fraction of radiation at the time of surgery, enabling patients to undergo both surgery and radiation in a single session. Our current study analyzed the value of incorporating breast MRI into the routine work-up of patients deemed eligible for IORT, to quantify the impact on patient eligibility and requirement for additional work-up...
March 2018: Surgical Oncology
https://www.readbyqxmd.com/read/29538255/the-role-of-radiotherapy-in-extramammary-paget-disease-a-systematic-review
#18
L Tagliaferri, C Casà, G Macchia, A Pesce, G Garganese, B Gui, G Perotti, S Gentileschi, F Inzani, R Autorino, S Cammelli, A G Morganti, V Valentini, M A Gambacorta
OBJECTIVE/PURPOSE: Extramammary Paget disease (EMPD) is a rare neoplasm of the skin generally affecting the anogenital area. Because of the low-frequency of the disease, no specific guidelines about the treatment strategy are available. Surgery is the recommended therapy for resectable and localized disease, but several other local treatments have been reported such as radiotherapy (RT). Most articles report small retrospective studies, referring to patients treated decades ago with large heterogeneity in terms of RT dose and technique...
March 17, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29536970/successful-treatment-of-metastatic-extramammary-paget-s-disease-with-pemetrexed-monotherapy-systematically-and-5-fluorouracil-topically
#19
Kexu Chen, Hanlin Liang, Jiewen Peng, Yanfang Zheng
Advanced extramammary Paget's disease does not have a standardized treatment guideline as its incidence is low and has been rarely reported in literature. Here we describe a case of metastatic extramammary Paget's disease successfully treated with topical 5-fluorouracil (5-FU) and systemic pemetrexed. The therapy was safe without any appreciable adverse effects like diarrhea, rash, neutropenia or fatigue; maintaining remission for more than 6 months. Thus, we propose 5-FU and pemetrexed as the first-line therapy for advanced extramammary Paget's disease, especially for aged patients with unresectable skin lesions...
March 12, 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29517496/intraoperative-immunostaining-for-cytokeratin-7-during-mohs-micrographic-surgery-demonstrates-low-local-recurrence-rates-in-extramammary-paget-s-disease
#20
MULTICENTER STUDY
Ali A Damavandy, Vitaly Terushkin, John A Zitelli, David G Brodland, Christopher J Miller, Jeremy R Etzkorn, Thuzar M Shin, Mark A Cappel, Mario Mitkov, Ali Hendi
BACKGROUND: Extramammary Paget's disease (EMPD) is a rare intraepithelial malignancy with high recurrence rates following standard surgical treatments, ranging from 22% to 60% in large retrospective reviews. OBJECTIVE: To evaluate the local recurrence rate of Mohs micrographic surgery (MMS) supplemented with intraoperative immunohistochemistry for cytokeratin-7 (MMS + CK-7) for primary and recurrent EMPD. MATERIALS AND METHODS: Retrospective, multi-center, cross-sectional study of patients treated using MMS + CK-7...
March 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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