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https://www.readbyqxmd.com/read/29115681/imiquimod-5-cream-as-a-therapeutic-option-for-extramammary-paget-s-disease
#1
Masahide Sawada, Junji Kato, Toshiharu Yamashita, Akihiro Yoneta, Tokimasa Hida, Kohei Horimoto, Sayuri Sato, Hisashi Uhara
A wide local excision is the standard treatment for extramammary Paget's disease (EMPD), though this treatment often leads to permanent anogenital mutilation and functional impairment. The purpose of our study is to evaluate the efficacy and safety of the topical application of imiquimod 5% cream for non-invasive EMPD. We examined nine patients with EMPD. Eight of the nine patients were treated with imiquimod 5% cream three times per week for 16 weeks; one case was treated for 6 weeks. The response rate was 100% including five complete remissions...
November 8, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29113769/advanced-scrotal-extramammary-paget-s-disease-treated-with-apatinib-a-case-report
#2
Yun-Ni Zhang, Ye Chen, Feng Gao, Ni Chen, Ji-Yan Liu
No abstract text is available yet for this article.
October 16, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29082243/mammary-and-extramammary-paget-s-disease-presented-different-expression-pattern-of-steroid-hormone-receptors
#3
Songxia Zhou, Weixiang Zhong, Ruiqin Mai, Guohong Zhang
BACKGROUND AND OBJECTIVES: Paget's disease (PD) is a rare intraepithelial adenocarcinoma, which is composed of mammary (MPD) and extramammary Paget's disease (EMPD). Currently, the published literature contains scant data on expression pattern of steroid hormone receptors in MPD and EMPD. METHODS: Expression of estrogen receptor (ER) and androgen receptor (AR) was evaluated in 88 MPD and 72 EMPD by using immunohistochemical staining and H-score method. RESULTS: Positive expression of AR was significantly higher in EMPD (61...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29079166/benefits-of-urologic-dermatologic-consultations-for-the-diagnosis-of-cutaneous-penile-lesions-a%C3%A2-prospective-study
#4
Edouard Fortier, Arnaud Cerruti, Christian Le Clec'h, Abdel-Rahmène Azzouzi, Pierre Bigot
INTRODUCTION: We evaluated the benefits of a specialized consultation created in 2014 for cutaneous penile lesions. MATERIALS AND METHODS: We performed a descriptive prospective study evaluating all patients sent for a monthly urologic-dermatologic consultation at a French university hospital from September 2014 to September 2015 for cutaneous penile lesions. All patients evaluated were included. We collected the demographic data, clinical examination findings, and the proposed diagnosis and treatment for every patient...
October 5, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29072945/neuroendocrine-tumors-of-the-breast
#5
REVIEW
Lauren Elizabeth Rosen, Paolo Gattuso
Primary neuroendocrine tumors of the breast are a rare and underrecognized subtype of mammary carcinoma. Neuroendocrine tumors of the breast occur predominately in postmenopausal women. The tumors are subclassified into well-differentiated and poorly differentiated neuroendocrine tumors, and invasive breast carcinoma with neuroendocrine features. Well-differentiated tumors show architectural similarity to carcinoids of other sites but lack characteristic neuroendocrine nuclei. Poorly differentiated neuroendocrine tumors are morphologically identical to small cell carcinoma of the lung...
November 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29054795/topical-ala-pdt-as-alternative-therapeutic-option-in-treatment-recalcitrant-dermatosis-report-of-4-cases
#6
REVIEW
Calvina Theresia, Jie Zheng, Xiao-Ying Chen
BACKGROUND: Topical Photodynamic therapy (PDT) is widely acknowledged for its safety and effectiveness in treating oncologic skin diseases such as basal cell carcinoma, actinic keratosis and squamous cell carcinoma in situ. Despite its broad applications in dermatology, this method is a relatively new therapeutic option for treating inflammatory/infectious skin diseases. OBJECTIVES: To determine whether topical PDT is a safe and effective treatment option in treating treatment-recalcitrant dermatosis...
October 17, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29033402/5-aminolevulinic-acid-5-ala-fluorescence-guided-mohs-surgery-resection-of-penile-scrotal-extramammary-paget-s-disease
#7
Xiaoqiong Peng, Wei Qian, Jiangang Hou
This report aims to evaluate the usefulness of 5-aminolevulinic acid (5-ALA) fluorescence-guided Mohs surgery resection of penile-scrotal extramammary Paget's disease for achieving maximum tumor resection. Between January 2014 and December 2015, 5 patients underwent surgical resection of a penile-scrotal extramammary Paget's disease in department of urology, Huashan hospital, Fudan University. All patients were coated with 5-ALA (concentration of 20%) throughout the scrotum and the visible range of the lesion plus a 2cm margin 3 hours before the induction of anesthesia...
October 16, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28992669/-a-case-of-secondary-extramammary-paget-s-disease-aroundthe-cutaneous-stoma-after-radical-cystectomy
#8
Sohei Kanda, Kazutoshi Okubo, Takuya Hida, Jin Kono, Takeshi Takahashi, Kenji Mitsumori, Toshihide Shimada, Kazuo Nishimura
We present a case of secondary extramammary Paget's disease around the cutaneous ureterostomy stoma after radical cystectomy. An 85-year-old man with bacillus calmette-guérin refractory high-grade urothelial carcinoma underwent radical cystectomy and cutaneous ureterostomy construction. After right ureter cancer diagnosis, he underwent right nephroureterectomy 3 years after the cystectomy. He developed refractory dermatitis around the cutaneous stoma 1 year after the nephroureterectomy. Skin biopsy revealed secondary extramammary Paget's disease, cured by skin excision around the cutaneous stoma and skin grafting...
September 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28976448/invasive-paget-disease-of-the-vulva
#9
Chiara Borghi, Giorgio Bogani, Antonino Ditto, Fabio Martinelli, Mauro Signorelli, Valentina Chiappa, Cono Scaffa, Stefania Perotto, Umberto Leone Roberti Maggiore, Dario Recalcati, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: Extramammary Paget disease of the vulva (EPDV) is a rare occurrence with an indolent and relapsing course. Progression to invasion occurs in 4% to 19% of cases. The aim of this study is to report clinical-pathological features and outcomes of patients treated for invasive EPDV. METHODS: Data of consecutive patients treated between 2000 and 2017 for invasive EPDV were reviewed. RESULTS: Among 79 patients with EPDV, 10 (12.7%) presented a microinvasive or invasive form at first diagnosis or during follow-up...
October 3, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28945622/clinical-benefits-of-preoperative-conventional-fluorescence-diagnosis-in-surgical-treatment-of-extramammary-paget-disease
#10
Miaojian Wan, Han Ma, Yue Zhao, Lin Xie, Zhirui Chen
BACKGROUND: In extramammary Paget disease (EMPD), initial margins of surgical excision are difficult to determine preoperatively. Fluorescence diagnosis (FD) may have utility as a noninvasive method for delineating tumor boundaries. OBJECTIVE: The relationship between FD-delineated borders and results of multiple scouting biopsies (MSBs) in EMPD was investigated, evaluating the potential clinical role of FD. MATERIALS AND METHODS: A cohort of 21 patients was studied, looking for consistencies between FD and MSB results...
September 20, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28935274/a-matter-of-margins-surgical-and-pathologic-risk-factors-for-recurrence-in-extramammary-paget-s-disease
#11
Beverly Long, Adam R Schmitt, Amy L Weaver, Michaela McGree, Jamie N Bakkum-Gamez, Jerry Brewer, William A Cliby
OBJECTIVES: To determine surgical and pathologic variables associated with recurrence in extramammary Paget's disease (EMPD). METHODS: Medical records of patients seeking care for EMPD from 1/1992-9/2015 were reviewed. Follow-up was restricted to 5years following primary surgery. Recurrence-free survival (RFS) was estimated using the Kaplan-Meier method. Risk factors were evaluated for an association with recurrence and positive margins, respectively, using Cox proportional hazards regression and logistic regression...
November 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28918854/erratum-to-extramammary-paget-s-disease-of-the-oral-mucosa-and-perioral-skin-oral-surg-oral-med-oral-pathol-oral-radiol-2017-124-2-e157-e163
#12
Xiangjian Wang, Lanyan Wu, Xueke Shi, Xin He, Wei Li, Hongmei Zhou
No abstract text is available yet for this article.
November 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28900484/chemokine-receptors-cxcr4-and-cxcr7-are-associated-with-tumor-aggressiveness-and-prognosis-in-extramammary-paget-disease
#13
Kun Chang, Gao-Xiang Li, Yun-Yi Kong, Xu-Xia Shen, Yuan-Yuan Qu, Zhong-Wei Jia, Yue Wang, Bo Dai, Ding-Wei Ye
Chemokines are involved in many aspects of oncogenesis, including regulation of cancer cell growth, dissemination and host-tumor response. However, the potential of the chemokine receptors, CXCR4 and CXCR7, in serving as biomarkers in extramammary Paget's disease (EMPD) has been rarely examined. Expressions of CXCR4 and CXCR7 were evaluated in 92 EMPD specimens by immunohistochemistry. High expression of CXCR4 and CXCR7 were both correlated with regional lymph node metastasis and presence of lymphovascular invasion...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28893632/patients-experiences-with-extramammary-paget-s-disease-an-online-pilot-study-querying-a-patient-support-group
#14
Paul H Chung, Jeremy T Kampp, Bryan B Voelzke
OBJECTIVE: To illustrate the heterogeneous care delivered to patients with Extramammary Paget's Disease (EMPD), a rare and lethal malignancy with poorly described treatment methodologies, by characterizing the clinical and pathological characteristics of an international patient support group. METHODS: Institutional review board approval was obtained to develop and distribute a non-validated survey to patients from an international, online EMPD support group. The survey was developed to capture patient clinical and pathological details and was distributed between January 2017 and February 2017...
September 8, 2017: Urology
https://www.readbyqxmd.com/read/28891079/successful-ts-1-monotherapy-as-the-second-line-treatment-for-advanced-extramammary-paget-s-disease-a-report-of-two-cases
#15
Junji Kato, Tokimasa Hida, Toshiharu Yamashita, Shiori Kamiya, Kohei Horimoto, Sayuri Sato, Hitomi Takahashi, Masahide Sawada, Mao Yamada, Hisashi Uhara
There is no standard chemotherapeutic treatment for advanced extramammary Paget's disease, though the effectiveness of some chemotherapy regimens, including docetaxel, has been reported. In this report, we report that TS-1 monotherapy was effective in two patients with advanced extramammary Paget's disease after docetaxel treatment failure. TS-1 monotherapy may be useful as the second-line treatment for patients with advanced extramammary Paget's disease.
September 11, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28887080/a-rare-case-of-metastatic-extramammary-paget-disease-of-the-spine-and-review-of-the-literature
#16
A Karim Ahmed, C Rory Goodwin, Nancy Abu-Bonsrah, Doreen Nguyen, Daniel M Sciubba
Extramammary Paget disease is an intraepithelial neoplasm affecting cells rich in apocrine glands-often located in the vulvar, scrotal, or perianal region. It typically affects older patients, between the ages of 50 and 80years old, and is most often limited to the epidermis. A 47-year-old Asian male first presented with enlargement of the right inguinal lymph node. A subsequent biopsy revealed extrammamary Paget disease of the scrotum. The patient eventually developed significant worsening back pain with bilateral lower extremity numbness and weakness three months later...
November 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28846155/dermoscope-guided-lesional-biopsy-to-diagnose-ema-ck7-ck20-extramammary-paget-s-disease-with-an-extensive-lesion
#17
Antonio Chuh, Vijay Zawar, Regina Fölster-Holst
Dermoscopy has been reported to facilitate the diagnosis of extramammary Paget's disease (EMPD).(1-3) We report here the first application of dermoscope-guided lesional biopsy to confirm the diagnosis of EMPD. A 60-year-old male presented with a pruritic and painful rash over his left groin region for six months. This article is protected by copyright. All rights reserved.
August 28, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28827914/extramammary-paget-s-disease-of-the-perianal-region
#18
S Devaji Rao, Meera Govindarajan
Extramammary Paget's disease (EMPD) is uncommon and only a few cases have been reported in the literature. They are identical to the Mammary Paget's disease. This can occur where the apocrine glands are in abundance, more commonly in the genitalia and perianal area. We report here a case of Extramammary Paget's disease in the perianal region. The colourful background of this ulcer is analysed and the literature reviewed.
August 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28751104/myofibroblastic-fibroblastic-and-myoid-lesions-of-the-breast
#19
REVIEW
Gregor Krings, Patrick McIntire, Sandra J Shin
Myofibroblastic, fibroblastic and/or myoid lesions are rare in the breast but comprise the majority of mammary mesenchymal spindle cell lesions. Whereas most have similar features to their counterparts at extramammary sites, pseudoangiomatous stromal hyperplasia is considered a breast-specific myofibroblastic proliferation on the same spectrum as myofibroblastoma. Other lesions with myofibroblastic/fibroblastic differentiation include fibromatosis and nodular fasciitis, as well as more aggressive tumors such as the rarely reported myofibrosarcoma, inflammatory myofibroblastic tumor and fibrosarcoma...
September 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28731239/new-technology-discloses-the-tumour-margin-of-extramammary-paget-disease
#20
COMMENT
N Hatta
No abstract text is available yet for this article.
July 2017: British Journal of Dermatology
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