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mammographic density

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https://www.readbyqxmd.com/read/28633324/mammographic-density-reduction-as-a-prognostic-marker-for-postmenopausal-breast-cancer-results-using-a-joint-longitudinal-survival-modelling-approach
#1
Therese M-L Andersson, Michael J Crowther, Kamila Czene, Per Hall, Keith Humphreys
Previous studies have linked reductions in mammographic density after a breast cancer diagnosis to an improved prognosis. These studies focused on short-term change, using a two-stage process, treating estimated change as a fixed covariate in a survival model. We propose the use of a joint longitudinal-survival model. This enables us to model long-term trends in density while accounting for drop-out as well as for measurement error. We study the change in mammographic density after a breast cancer diagnosis and its association with prognosis (measured by cause-specific mortality), overall and with respect to hormone replacement therapy and tamoxifen treatment...
June 13, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28624977/interaction-of-mammographic-breast-density-with-menopausal-status-and-postmenopausal-hormone-use-in-relation-to-the-risk-of-aggressive-breast-cancer-subtypes
#2
Lusine Yaghjyan, Rulla M Tamimi, Kimberly A Bertrand, Christopher G Scott, Matthew R Jensen, V Shane Pankratz, Kathy Brandt, Daniel Visscher, Aaron Norman, Fergus Couch, John Shepherd, Bo Fan, Yunn-Yi Chen, Lin Ma, Andrew H Beck, Steven R Cummings, Karla Kerlikowske, Celine M Vachon
PURPOSE: We examined the associations of mammographic breast density with breast cancer risk by tumor aggressiveness and by menopausal status and current postmenopausal hormone therapy. METHODS: This study included 2596 invasive breast cancer cases and 4059 controls selected from participants of four nested case-control studies within four established cohorts: the Mayo Mammography Health Study, the Nurses' Health Study, Nurses' Health Study II, and San Francisco Mammography Registry...
June 17, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28621548/an-investigation-into-the-mammographic-appearances-of-missed-breast-cancers-when-recall-rates-are-reduced
#3
Norhashimah Mohd Norsuddin, Claudia Mello-Thoms, Warren Reed, Mary Rickard, Sarah Lewis
OBJECTIVES: This study investigated whether certain mammographic appearances of breast cancer are missed when radiologists read at lower recall rates. METHODS: Five radiologists read one identical test set of 200 mammographic (180 normal cases and 20 abnormal cases) three times and were requested to adhere to three different recall rate conditions: free recall, 15% and 10%. The radiologists were asked to mark the locations of suspicious lesions and provide a confidence rating for each decision...
June 16, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28613915/inter-country-analysis-of-breast-density-classification-using-visual-grading
#4
Christine N Damases, Peter Hogg, Mark F McEntee
OBJECTIVE: Disagreement in mammographic breast density (MBD) assessment can impact breast cancer risk stratification, choices of further breast cancer screening intervals and pathways. This study examines whether inter-country MBD expectations and assessment approaches are associated with differences in MBD assessment. METHODS: Twenty American Board of Radiology (ABR) examiners and 24 United Kingdom (UK) practitioners using the 4(th) edition BI-RADS(®) lexicon assessed 40 mammogram cases of 20 women...
June 14, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28583146/the-effect-of-volumetric-breast-density-on-the-risk-of-screen-detected-and-interval-breast-cancers-a-cohort-study
#5
Johanna O P Wanders, Katharina Holland, Nico Karssemeijer, Petra H M Peeters, Wouter B Veldhuis, Ritse M Mann, Carla H van Gils
BACKGROUND: In the light of the breast density legislation in the USA, it is important to know a woman's breast cancer risk, but particularly her risk of a tumor that is not detected through mammographic screening (interval cancer). Therefore, we examined the associations of automatically measured volumetric breast density with screen-detected and interval cancer risk, separately. METHODS: Volumetric breast measures were assessed automatically using Volpara version 1...
June 5, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28575868/increased-breast-tissue-receptor-activator-of-nuclear-factor-%C3%AE%C2%BAb-ligand-rankl-gene-expression-is-associated-with-higher-mammographic-density-in-premenopausal-women
#6
Adetunji T Toriola, Ha X Dang, Ian S Hagemann, Catherine M Appleton, Graham A Colditz, Jingqin Luo, Christopher A Maher
Increased mammographic breast density is associated with a 4-6-fold increased risk of breast cancer, yet lifestyle factors that can reduce dense breasts are yet to be identified, and viable prevention strategies to reduce breast density-associated breast cancer development are yet to be developed. We investigated the associations of breast tissue receptor activator of nuclear factor-κB (RANK) pathway gene expression with mammographic density in 48 premenopausal women, with no previous history of cancer. Gene expression levels were measured in total RNA isolated from formalin-fixed paraffin-embedded breast tissue samples, using the NanoString nCounter platform...
May 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28573551/two-dimensional-breast-dosimetry-improved-using-three-dimensional-breast-image-data
#7
REVIEW
John M Boone, Andrew M Hernandez, J Anthony Seibert
Conventional mammographic dosimetry has been developed over the past 40 years. Prior to the availability of high-resolution three-dimensional breast images, certain assumptions about breast anatomy were required. These assumptions were based on the information evident on two-dimensional mammograms; they included assumptions of thick skin, a uniform mixture of glandular and adipose tissue, and a median breast density of 50%. Recently, the availability of high-resolution breast CT studies has provided more accurate data about breast anatomy, and this, in turn, has provided the opportunity to update mammographic dosimetry...
June 1, 2017: Radiological Physics and Technology
https://www.readbyqxmd.com/read/28572739/patient-comfort-from-the-technologist-perspective-factors-to-consider-in-mammographic-imaging
#8
Christina C Mendat, Dave Mislan, Lisa Hession-Kunz
A sample size of 280 certified mammography technologists were surveyed to understand what factors affect patient discomfort during breast imaging. Given mammography technologists' level of patient involvement, they are uniquely positioned to observe factors that affect patient comfort. The findings suggest that according to technologists, multiple factors, including patient ethnicity, breast density, previous biopsy and lumpectomy experience, as well as psychological factors, impact breast discomfort during mammography...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28565960/comparison-of-subjective-and-fully-automated-methods-for-measuring-mammographic-density
#9
Nataliia Moshina, Marta Roman, Sofie Sebuødegård, Gunvor G Waade, Giske Ursin, Solveig Hofvind
Background Breast radiologists of the Norwegian Breast Cancer Screening Program subjectively classified mammographic density using a three-point scale between 1996 and 2012 and changed into the fourth edition of the BI-RADS classification since 2013. In 2015, an automated volumetric breast density assessment software was installed at two screening units. Purpose To compare volumetric breast density measurements from the automated method with two subjective methods: the three-point scale and the BI-RADS density classification...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28561776/qualitative-versus-quantitative-mammographic-breast-density-assessment-applications-for-the-us-and-abroad
#10
REVIEW
Stamatia Destounis, Andrea Arieno, Renee Morgan, Christina Roberts, Ariane Chan
Mammographic breast density (MBD) has been proven to be an important risk factor for breast cancer and an important determinant of mammographic screening performance. The measurement of density has changed dramatically since its inception. Initial qualitative measurement methods have been found to have limited consistency between readers, and in regards to breast cancer risk. Following the introduction of full-field digital mammography, more sophisticated measurement methodology is now possible. Automated computer-based density measurements can provide consistent, reproducible, and objective results...
May 31, 2017: Diagnostics
https://www.readbyqxmd.com/read/28558329/risk-stratification-of-women-with-false-positive-test-results-in-mammography-screening-based-on-mammographic-morphology-and-density-a-case-control-study
#11
Rikke Rass Winkel, My von Euler-Chelpin, Elsebeth Lynge, Pengfei Diao, Martin Lillholm, Michiel Kallenberg, Julie Lyng Forman, Michael Bachmann Nielsen, Wei Yao Uldall, Mads Nielsen, Ilse Vejborg
The long-term risk of breast cancer is increased in women with false-positive (FP) mammography screening results. We investigated whether mammographic morphology and/or density can be used to stratify these women according to their risk of future breast cancer METHODS: We undertook a case-control study nested in the population-based screening programme in Copenhagen, Denmark. We included 288 cases and 288 controls based on a cohort of 4743 women with at least one FP-test result in 1991-2005 who were followed up until 17 April 2008...
May 27, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28545469/age-related-terminal-duct-lobular-unit-involution-in-benign-tissues-from-chinese-breast-cancer-patients-with-luminal-and-triple-negative-tumors
#12
Changyuan Guo, Hyuna Sung, Shan Zheng, Jennifer Guida, Erni Li, Jing Li, Nan Hu, Joseph Deng, Jonine D Figueroa, Mark E Sherman, Gretchen L Gierach, Ning Lu, Xiaohong R Yang
BACKGROUND: Terminal duct lobular unit (TDLU) involution is a physiological process of breast tissue aging characterized by a reduction in the epithelial component. In studies of women with benign breast disease, researchers have found that age-matched women with lower levels of TDLU involution are at increased risk of developing breast cancer. We previously showed that breast cancer cases with core basal phenotype (CBP; estrogen receptor negative [ER(-)], progesterone receptor-negative [PR(-)], human epidermal growth factor receptor 2-negative [HER2(-)], cytokeratins (CK 5 or CK5/6)-positive [CK5/6(+)] and/or epidermal growth factor receptor-positive [EGFR(+)]) tumors had significantly reduced TDLU involution compared with cases with luminal A (ER(+) and/or PR(+), HER2(-), CK5/6(-), EGFR(-)) tumors from a population-based case-control study in Poland...
May 25, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28515107/a-randomized-double-blind-placebo-controlled-trial-of-the-effect-of-vitamin-d3-supplementation-on-breast-density-in-premenopausal-women
#13
Jacques Brisson, Sylvie Bérubé, Caroline Diorio, Benoit Masse, Julie Lemieux, Thierry Duchesne, Edgar Delvin, Reinhold Vieth, Martin J Yaffe, Jocelyne Chiquette
BACKGROUND: This double-blind, placebo-controlled parallel-group trial assessed whether oral supplementation with 1,000, 2,000 or 3,000 IU/day vitamin D3 over one year reduces percent mammographic breast density in premenopausal women. METHODS: The trial was conducted between October 2012 and June 2015, among premenopausal female volunteers from Quebec City (Quebec, Canada). Women were randomized with ratio 1:1:1:1 to one of four study arms (1,000, 2,000 or 3,000 IU/d vitamin D3 or placebo)...
May 17, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28512241/assessment-of-breast-cancer-risk-factors-reveals-subtype-heterogeneity
#14
Johanna Holm, Louise Eriksson, Alexander Ploner, Mikael Eriksson, Mattias Rantalainen, Jingmei Li, Per Hall, Kamila Czene
Subtype heterogeneity for breast cancer risk factors has been suspected, potentially reflecting etiological differences and implicating risk prediction. However, reports are conflicting regarding presence of heterogeneity for many exposures. To examine subtype heterogeneity across known breast cancer risk factors, we conducted a case-control analysis of 2,632 breast cancers and 15,945 controls in Sweden. Molecular subtype was predicted from pathology-record derived immunohistochemistry markers by a classifier trained on PAM50 subtyping...
May 16, 2017: Cancer Research
https://www.readbyqxmd.com/read/28495213/breast-density-legislation-in-new-england-a-survey-study-of-practicing-radiologists
#15
Ana P Lourenco, Roberta M DiFlorio-Alexander, Priscilla J Slanetz
RATIONALE AND OBJECTIVES: This study aimed to assess radiologists' knowledge about breast density legislation as well as perceived practice changes resulting from the enactment of breast density legislation. MATERIALS AND METHODS: This is an institutional review board-exempt anonymous email survey of 523 members of the New England Roentgen Ray Society. In addition to radiologist demographics, survey questions addressed radiologist knowledge of breast density legislation, knowledge of breast density as a risk factor for breast cancer, recommendations for supplemental screening, and perceived practice changes resulting from density notification legislation...
May 8, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28489877/low-back-pain-in-healthy-postmenopausal-women-and-the-effect-of-physical-activity-a-secondary-analysis-in-a-randomized-trial
#16
Mirca Marini, Benedetta Bendinelli, Melania Assedi, Daniela Occhini, Maria Castaldo, Jacopo Fabiano, Marco Petranelli, Mario Migliolo, Marco Monaci, Giovanna Masala
Epidemiological studies on the prevalence of musculoskeletal pain have consistently shown that this is a relevant health problem, with non-specific low back pain (LBP) being the most commonly reported in adult females. Conflicting data on the association between LBP symptoms and physical activity (PA) have been reported. Here, we investigated the prevalence of LBP and the effect of a 24-month non-specific PA intervention on changes in LBP prevalence in a series of Italian healthy postmenopausal women. We performed a secondary analysis in the frame of the DAMA trial, a factorial randomized intervention trial aimed to evaluate the ability of a 24-month intervention, based on moderate-intensity PA, and/or dietary modification, in reducing mammographic breast density in healthy postmenopausal women...
2017: PloS One
https://www.readbyqxmd.com/read/28473194/association-of-catechol-o-methyltransferase-polymorphism-val158met-and-mammographic-density-a-meta-analysis
#17
Roope A Kallionpää, Elina Uusitalo, Juha Peltonen
OBJECTIVES: The Val158Met polymorphism in catechol-O-methyltransferase (COMT) enzyme reduces the methylation of catechol estrogens, which may affect mammographic density. High mammographic density is a known risk factor of breast cancer. Our aim was to perform meta-analysis of the effect of COMT Val158Met polymorphism on mammographic density. METHODS: Original studies reporting data on mammographic density, stratified by the presence of COMT Val158Met polymorphism, were identified and combined using genetic models Met/Val vs...
August 15, 2017: Gene
https://www.readbyqxmd.com/read/28464481/correlation-of-mammographic-density-and-serum-calcium-levels-in-patients-with-primary-breast-cancer
#18
Carolin C Hack, Martin J Stoll, Sebastian M Jud, Katharina Heusinger, Werner Adler, Lothar Haeberle, Thomas Ganslandt, Felix Heindl, Rüdiger Schulz-Wendtland, Alexander Cavallaro, Michael Uder, Matthias W Beckmann, Peter A Fasching, Christian M Bayer
Percentage mammographic breast density (PMD) is one of the most important risk factors for breast cancer (BC). Calcium, vitamin D, bisphosphonates, and denosumab have been considered and partly confirmed as factors potentially influencing the risk of BC. This retrospective observational study investigated the association between serum calcium level and PMD. A total of 982 BC patients identified in the research database at the University Breast Center for Franconia with unilateral BC, calcium and albumin values, and mammogram at the time of first diagnosis were included...
June 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28458473/screening-methods-clinical-breast-examination-and-mammography-to-detect-breast-cancer-in-women-aged-40-49-years
#19
Navneet Takkar, Suman Kochhar, Priyanka Garg, A K Pandey, Usha Rani Dalal, Uma Handa
OBJECTIVE: The aim of this study is to detect breast cancer rate, nodal status, tumor size, and associated risk factors using clinical breast examination (CBE) and mammography as screening tools in women aged 40-49 years. MATERIALS AND METHODS: A total of 500 women were screened in a time period of 2 years, between the ages of 40-49 years for breast cancer. Screening tools used were CBE and mammography. Clinical history and risk factors related to breast cancer were recorded...
January 2017: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28456099/thyroid-disorders-and-mammographic-density-in-spanish-women-var-ddm-study
#20
Ana María Pedraza-Flechas, Virginia Lope, Carmen Vidal, Carmen Sánchez-Contador, Carmen Santamariña, Carmen Pedraz-Pingarrón, Pilar Moreo, Nieves Ascunce, Josefa Miranda-García, Rafael Llobet, Nuria Aragonés, Dolores Salas-Trejo, Marina Pollán, Beatriz Pérez-Gómez
OBJECTIVES: The association between breast cancer (BC) and thyroid disorders has been widely explored with unclear results. Mammographic density (MD) is one of the strongest risk factor for BC. This study explores the relationship between thyroid diseases and MD in Spanish women. MATERIALS & METHODS: This cross-sectional study covered 2883 women aged 47-71 years participating in 7 BC screening programs in 2010. They allowed access to their mammograms, had anthropometrical-measures taken, and answered a telephonic epidemiological interview which included specific questions on thyroid diseases...
April 26, 2017: Breast: Official Journal of the European Society of Mastology
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