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mammographic density

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https://www.readbyqxmd.com/read/29790170/calculation-of-breast-volumes-from-mammogram-comparison-of-four-separate-equations-relative-to-mastectomy-specimen-volumes
#1
Jack W Rostas, Neal Bhutiani, Morgan Crigger, Stacey M W Crawford, Reiss B Hollenbach, Samantha R Heidrich, Robert C G Martin, Kelly M McMasters, Nicolás Ajkay
BACKGROUND AND OBJECTIVES: Accurately assessing breast volume (BV) relative to the volume of breast tissue to be removed could help objectively determine the optimal surgical candidates for breast conserving surgery. The objective of this study was to determine the optimal mammography-based method of BV estimation. METHODS: Mammography data was obtained for patients who underwent mastectomy for breast cancer from 2005 to 2015. This data was used to calculate BV using four previously published equations...
May 22, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29743035/mammographic-density-changes-in-surgical-weight-loss-an-indication-for-personalized-screening
#2
Natalia Partain, Ali Mokdad, Nancy Puzziferri, Jessica Porembka, Stephen Seiler, Alana Christie, Deborah Farr, Aeisha Rivers, A Marilyn Leitch, Rachel Wooldridge, James Huth, Roshni Rao
BACKGROUND: Obesity and high radiologic breast density independently increase breast cancer risk. We evaluated the effect of surgical weight loss on mammographic density (MD). METHODS: Patients undergoing bariatric surgery and screening mammography (MG) were identified, data regarding demographics, comorbidities, calculated and genetic breast cancer risk was collected. Patients had a MG before and after surgery. Fellowship-trained breast radiologists assigned Breast Imaging Reporting and Data System density categories...
May 9, 2018: BMC Medical Imaging
https://www.readbyqxmd.com/read/29723697/an-exploratory-radiomics-analysis-on-digital-breast-tomosynthesis-in-women-with-mammographically-negative-dense-breasts
#3
Alberto Stefano Tagliafico, Francesca Valdora, Giovanna Mariscotti, Maunela Durando, Jacopo Nori, Daniele La Forgia, Ilan Rosenberg, Francesca Caumo, Nicoletta Gandolfo, Nehmat Houssami, Massimo Calabrese
PURPOSE: To compare Digital Breast Tomosynthesis (DBT) for cancers and normal screens in women with dense breasts and negative mammography using a Radiomics approach. MATERIALS AND METHODS: A substudy (N = 40) of the 'Adjunct Screening With Tomosynthesis or Ultrasound in Women With Mammography-Negative Dense Breasts (ASTOUND)' trial was done based on 20 women who had DBT-detected, histology-proven, breast cancer and 20 controls matched for age and density. Using a Radiomics approach normal and pathological breast parenchyma were evaluated, and correlations among Radiomics features and clinical and prognostic parameters were investigated...
April 30, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29720220/the-combined-effect-of-mammographic-texture-and-density-on-breast-cancer-risk-a-cohort-study
#4
Johanna O P Wanders, Carla H van Gils, Nico Karssemeijer, Katharina Holland, Michiel Kallenberg, Petra H M Peeters, Mads Nielsen, Martin Lillholm
BACKGROUND: Texture patterns have been shown to improve breast cancer risk segregation in addition to area-based mammographic density. The additional value of texture pattern scores on top of volumetric mammographic density measures in a large screening cohort has never been studied. METHODS: Volumetric mammographic density and texture pattern scores were assessed automatically for the first available digital mammography (DM) screening examination of 51,400 women (50-75 years of age) participating in the Dutch biennial breast cancer screening program between 2003 and 2011...
May 2, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29708782/mri-clinical-examination-and-mammography-for-preoperative-assessment-of-residual-disease-and-pathologic-complete-response-after-neoadjuvant-chemotherapy-for-breast-cancer-acrin-6657-trial
#5
John R Scheel, Eunhee Kim, Savannah C Partridge, Constance D Lehman, Mark A Rosen, Wanda K Bernreuter, Etta D Pisano, Helga S Marques, Elizabeth A Morris, Paul T Weatherall, Sandra M Polin, Gillian M Newstead, Laura J Esserman, Mitchell D Schnall, Nola M Hylton
OBJECTIVE: The objective of our study was to determine the accuracy of preoperative measurements for detecting pathologic complete response (CR) and assessing residual disease after neoadjuvant chemotherapy (NACT) in patients with locally advanced breast cancer. SUBJECTS AND METHODS: The American College of Radiology Imaging Network 6657 Trial prospectively enrolled women with ≥ 3 cm invasive breast cancer receiving NACT. Preoperative measurements of residual disease included longest diameter by mammography, MRI, and clinical examination and functional volume on MRI...
April 30, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29706765/correlation-between-mammographic-breast-density-breast-tissue-type-in-ultrasonography-fibroglandular-tissue-and-background-parenchymal-enhancement-in-magnetic-resonance-imaging
#6
Afsaneh Alikhassi, Seyedeh Nooshin Miratashi Yazdi, Hedieh Akbari, Sona Akbari Kia, Masoud Baikpour
Objective: Breast cancer is the most common malignancy in the female population, and imaging studies play a critical role for its early detection. Mammographic breast density (MBD) is one of the markers used to predict the risk stratification of breast cancer in patients. We aimed to assess the correlations among MBD, ultrasound breast composition (USBC), fibroglandular tissue (FGT), and the amount of background parenchymal enhancement (BPE) in magnetic resonance imaging, after considering the subjects' menopausal status...
2018: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/29694675/recurrence-quantification-analysis-of-radiologists-scanpaths-when-interpreting-mammograms
#7
Ziba Gandomkar, Kevin Tay, Patrick C Brennan, Claudia Mello-Thoms
PURPOSE: Proposing a classifier based on recurrence quantification analysis (RQA) metrics for distinguishing experts' scanpaths from those of less-experienced readers; and exploring the association of spatiotemporal dynamics of the mammographic scanpaths with characteristics of cases and radiologists using RQA metrics. MATERIALS AND METHODS: Eye movements were recorded from eight radiologists (two cohorts: four experienced and four less-experienced) while reading 120 mammograms (59 cancer, 61 normal)...
April 25, 2018: Medical Physics
https://www.readbyqxmd.com/read/29691345/evaluating-mammographer-acceptance-of-mammorisk-software
#8
Jean Weigert, Nancy Cavanaugh, Talong Ju
PURPOSE: To evaluate mammographers' acceptance of the breast cancer risk assessment software tool MammoRisk (Statlife) in the clinical setting. METHODS: During a 6-month period, 1200 women undergoing routine mammography examinations at a regional, outpatient, comprehensive breast imaging center were assessed for breast cancer risk by mammographers who used the MammoRisk software. At the end of the 6-month period, the mammographers (N = 11) completed an 8-question survey on their willingness to the use of the software in the clinical setting...
March 2018: Radiologic Technology
https://www.readbyqxmd.com/read/29687576/mammographic-breast-density-in-recent-and-longer-standing-ethiopian-immigrants-to-israel
#9
Miri Sklair-Levy, Anat Segev, Tamar Sella, Ronit Calderon-Margalit, Douglas Zippel
High breast density is associated with an increased risk of breast cancer development. Little is known concerning ethnic variations in breast density and its relevant contributing factors. We aimed to study breast density among Ethiopian immigrants to Israel in comparison with Israeli-born women and to determine any effect on breast density of the length of residency in the immigrant population. Mammographic breast density using the BI-RADS system was estimated and compared between 77 women of Ethiopian origin who live in Israel and 177 Israeli-born controls...
April 23, 2018: Breast Journal
https://www.readbyqxmd.com/read/29679262/serum-osteoprotegerin-levels-and-mammographic-density-among-high-risk-women
#10
Olivia Moran, Tasnim Zaman, Andrea Eisen, Rochelle Demsky, Kristina Blackmore, Julia A Knight, Christine Elser, Ophira Ginsburg, Kevin Zbuk, Martin Yaffe, Steven A Narod, Leonardo Salmena, Joanne Kotsopoulos
PURPOSE: Mammographic density is a risk factor for breast cancer but the mechanism behind this association is unclear. The receptor activator of nuclear factor κB (RANK)/RANK ligand (RANKL) pathway has been implicated in the development of breast cancer. Given the role of RANK signaling in mammary epithelial cell proliferation, we hypothesized this pathway may also be associated with mammographic density. Osteoprotegerin (OPG), a decoy receptor for RANKL, is known to inhibit RANK signaling...
April 20, 2018: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29671181/hormone-replacement-therapy-mammographic-density-and-breast-cancer-risk-a-cohort-study
#11
Shadi Azam, Theis Lange, Stephanie Huynh, Arja R Aro, My von Euler-Chelpin, Ilse Vejborg, Anne Tjønneland, Elsebeth Lynge, Zorana J Andersen
PURPOSE: Hormone replacement therapy (HRT) use increases breast cancer risk and mammographic density (MD). We examine whether MD mediates or modifies the association of HRT with the breast cancer. METHODS: For the 4,501 participants in the Danish diet, cancer and health cohort (1993-1997) who attended mammographic screening in Copenhagen (1993-2001), MD (mixed/dense or fatty) was assessed at the first screening after cohort entry. HRT use was assessed by questionnaire and breast cancer diagnoses until 2012 obtained from the Danish cancer registry...
April 18, 2018: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29669579/long-term-prognostic-implications-of-risk-factors-associated-with-tumor-size-a-case-study-of-women-regularly-attending-screening
#12
Fredrik Strand, Keith Humphreys, Johanna Holm, Mikael Eriksson, Sven Törnberg, Per Hall, Edward Azavedo, Kamila Czene
BACKGROUND: Breast cancer prognosis is strongly associated with tumor size at diagnosis. We aimed to identify factors associated with diagnosis of large (> 2 cm) compared to small tumors, and to examine implications for long-term prognosis. METHODS: We examined 2012 women with invasive breast cancer, of whom 1466 had screen-detected and 546 interval cancers that were incident between 2001 and 2008 in a population-based screening cohort, and followed them to 31 December 2015...
April 18, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29665850/common-genetic-variation-and-novel-loci-associated-with-volumetric-mammographic-density
#13
Judith S Brand, Keith Humphreys, Jingmei Li, Robert Karlsson, Per Hall, Kamila Czene
BACKGROUND: Mammographic density (MD) is a strong and heritable intermediate phenotype of breast cancer, but much of its genetic variation remains unexplained. METHODS: We conducted a genetic association study of volumetric MD in a Swedish mammography screening cohort (n = 9498) to identify novel MD loci. Associations with volumetric MD phenotypes (percent dense volume, absolute dense volume, and absolute nondense volume) were estimated using linear regression adjusting for age, body mass index, menopausal status, and six principal components...
April 17, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29658110/prenatal-diethylstilbestrol-des-exposure-and-mammographic-density
#14
William C Strohsnitter, Kimberly A Bertrand, Rebecca Troisi, Christopher G Scott, Andrea L Cheville, Robert N Hoover, Julie R Palmer, Celine M Vachon
In a prospective cohort study of the health effects associated with prenatal Diethylstilbestrol (DES) exposure, DES was associated with an increased breast cancer risk after 40 years of age. It is unknown whether it is associated with greater mammographic density, which strongly predicts breast cancer risk. A cohort of DES-exposed and unexposed women was assembled at the Mayo Clinic in 1975, and followed through 2012 as part of the National Cancer Institute's DES Follow-up Study. Mammographic density from 3,637 mammograms for 332 (222 DES-exposed, 110 unexposed) women in this cohort screened at the Mayo Clinic, Rochester between 1996 and 2015 were determined clinically using the Breast Imaging Reporting and Data System (BI-RADS)...
April 15, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29651637/an-overview-of-mammographic-density-and-its-association-with-breast-cancer
#15
REVIEW
Shayan Shaghayeq Nazari, Pinku Mukherjee
In 2017, breast cancer became the most commonly diagnosed cancer among women in the US. After lung cancer, breast cancer is the leading cause of cancer-related mortality in women. The breast consists of several components, including milk storage glands, milk ducts made of epithelial cells, adipose tissue, and stromal tissue. Mammographic density (MD) is based on the proportion of stromal, epithelial, and adipose tissue. Women with high MD have more stromal and epithelial cells and less fatty adipose tissue, and are more likely to develop breast cancer in their lifetime compared to women with low MD...
April 12, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/29626240/mammographic-density-changes-following-discontinuation-of-tamoxifen-in-premenopausal-women-with-oestrogen-receptor-positive-breast-cancer
#16
Won Hwa Kim, Nariya Cho, Young-Seon Kim, Ann Yi
OBJECTIVES: To evaluate the changes in mammographic density after tamoxifen discontinuation in premenopausal women with oestrogen receptor-positive breast cancers and the underlying factors METHODS: A total of 213 consecutive premenopausal women with breast cancer who received tamoxifen treatment after curative surgery and underwent three mammograms (baseline, after tamoxifen treatment, after tamoxifen discontinuation) were included. Changes in mammographic density after tamoxifen discontinuation were assessed qualitatively (decrease, no change, or increase) by two readers and measured quantitatively by semi-automated software...
April 6, 2018: European Radiology
https://www.readbyqxmd.com/read/29624213/should-breast-cancer-screening-programs-routinely-measure-mammographic-density
#17
Jennifer Stone
No abstract text is available yet for this article.
April 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29622545/pam50-and-risk-of-recurrence-scores-for-interval-breast-cancers
#18
Samantha Puvanesarajah, Sarah J Nyante, Cherie M Kuzmiak, Mengjie Chen, Chiu-Kit Tse, Xuezheng Sun, Emma H Allott, Erin L Kirk, Lisa A Carey, Charles M Perou, Andrew F Olshan, Louise M Henderson, Melissa A Troester
Breast cancers detected after a negative breast screening examination and prior to the next screening are referred to as interval cancers. These cancers generally have poor clinical characteristics compared to screen-detected cancers, but associations between interval cancer and genomic cancer characteristics are not well understood. Mammographically-screened women diagnosed with primary invasive breast cancer from 1993-2013 (n=370) were identified by linking the Carolina Breast Cancer Study and the Carolina Mammography Registry...
April 5, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29621362/long-term-accuracy-of-breast-cancer-risk-assessment-combining-classic-risk-factors-and-breast-density
#19
Adam R Brentnall, Jack Cuzick, Diana S M Buist, Erin J Aiello Bowles
Importance: Accurate long-term breast cancer risk assessment for women attending routine screening could help reduce the disease burden and intervention-associated harms by personalizing screening recommendations and preventive interventions. Objective: To report the accuracy of risk assessment for breast cancer during a period of 19 years. Design, Setting, and Participants: This cohort study of the Kaiser Permanente Washington breast imaging registry included women without previous breast cancer, aged 40 to 73 years, who attended screening from January 1, 1996, through December 31, 2013...
April 5, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29610032/personalized-prevention-in-high-risk-individuals-managing-hormones-and-beyond
#20
D Gareth Evans, Sacha J Howell, Anthony Howell
Increasing numbers of women are being identified at 'high-risk' of breast cancer, defined by The National Institute of Health and Care Excellence (NICE) as a 10-year risk of ≥8%. Classically women have been so identified through family history based risk algorithms or genetic testing of high-risk genes. Recent research has shown that assessment of mammographic density and single nucleotide polymorphisms (SNPs), when combined with established risk factors, trebles the number of women reaching the high risk threshold...
March 30, 2018: Breast: Official Journal of the European Society of Mastology
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