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mammographic density

Cecilia W Huo, Mark Waltham, Christine Khoo, Stephen B Fox, Prue Hill, Shou Chen, Grace L Chew, John T Price, Chau H Nguyen, Elizabeth D Williams, Michael Henderson, Erik W Thompson, Kara L Britt
BACKGROUND: High mammographic density (HMD) not only confers a significantly increased risk of breast cancer (BC) but also is associated with BCs of more advanced stages. However, it is unclear whether BC progression and metastasis are stimulated by HMD. We investigated whether patient-derived HMD breast tissue could stimulate the progression of cells compared with patient-matched low mammographic density (LMD) tissue. METHODS: Sterile breast specimens were obtained immediately after prophylactic mastectomy from high-risk women (n = 10)...
October 25, 2016: Breast Cancer Research: BCR
Michael W Cho, Lars J Grimm, Karen S Johnson
RATIONALE AND OBJECTIVES: This study aimed to determine the utility of directed ultrasound and digital mammogram for evaluating focal breast pain in women with different mammographic breast densities. MATERIALS AND METHODS: This institutional review board-approved and Health Insurance Portability and Accountability Act-compliant retrospective study included 413 cases of focal breast pain in 369 women (mean age 53 years). All cases were evaluated with both mammogram and ultrasound and had at least 2 years of imaging follow-up...
October 13, 2016: Academic Radiology
Rachel Denholm, Bianca De Stavola, John H Hipwell, Simon J Doran, Marta C Busana, Amanda Eng, Mona Jeffreys, Martin O Leach, David Hawkes, Isabel Dos Santos Silva
BACKGROUND: Breast density, the amount of fibroglandular tissue in the adult breast for a women's age and body mass index, is a strong biomarker of susceptibility to breast cancer, which may, like breast cancer risk itself, be influenced by events early in life. In the present study, we investigated the association between pre-natal exposures and breast tissue composition. METHODS: A sample of 500 young, nulliparous women (aged approximately 21 years) from a U...
October 12, 2016: Breast Cancer Research: BCR
F N Fjeldheim, H Frydenberg, V G Flote, A McTiernan, A-S Furberg, P T Ellison, E S Barrett, T Wilsgaard, G Jasienska, G Ursin, E A Wist, I Thune
BACKGROUND: Single nucleotide polymorphisms (SNPs) involved in the estrogen pathway and SNPs in the estrogen receptor alpha gene (ESR1 6q25) have been linked to breast cancer development, and mammographic density is an established breast cancer risk factor. Whether there is an association between daily estradiol levels, SNPs in ESR1 and premenopausal mammographic density phenotypes is unknown. METHODS: We assessed estradiol in daily saliva samples throughout an entire menstrual cycle in 202 healthy premenopausal women in the Norwegian Energy Balance and Breast Cancer Aspects I study...
October 7, 2016: BMC Cancer
Linda Linton, Monica Taylor, Sheila Dunn, Lisa Martin, Sonia Chavez, Greg Stanitz, Ella Huszti, Salomon Minkin, Norman Boyd
BACKGROUND: In previous work in young women aged 15-30 years we measured breast water and fat using MR and obtained blood for hormone assays on the same day in the follicular phase of the menstrual cycle. Only serum growth hormone levels and sex hormone binding globulin (SHBG) were significantly associated with percent breast water after adjustment for covariates. The sex hormones estradiol, progesterone and testosterone were not associated with percent water in the breast in the follicular phase of the menstrual cycle...
2016: PloS One
Fredrik Strand, Keith Humphreys, Abbas Cheddad, Sven Törnberg, Edward Azavedo, John Shepherd, Per Hall, Kamila Czene
BACKGROUND: Interval breast cancers are often diagnosed at a more advanced stage than screen-detected cancers. Our aim was to identify features in screening mammograms of the normal breast that would differentiate between future interval cancers and screen-detected cancers, and to understand how each feature affects tumor detectability. METHODS: From a population-based cohort of invasive breast cancer cases in Stockholm-Gotland, Sweden, diagnosed from 2001 to 2008, we analyzed the contralateral mammogram at the preceding negative screening of 394 interval cancer cases and 1009 screen-detected cancers...
October 5, 2016: Breast Cancer Research: BCR
Arda Kayhan, Erkin Arıbal, Cennet Şahin, Ömür Can Taşçı, Sibel Özkan Gürdal, Enis Öztürk, Hayat Halide Hatipoğlu, Nilüfer Özaydın, Neslihan Cabioğlu, Beyza Özçınar, Vahit Özmen
PURPOSE: Bahçeşehir Breast Cancer Screening Program is a population based organized screening program in Turkey, where asymptomatic women aged 40-69 years are screened biannually. In this prospective study, we aimed to determine the mammographic findings of screen-detected cancers and discuss the efficacy of breast cancer screening in a developing country. METHODS: A total of 6912 women were screened in three rounds. The radiologic findings were grouped as mass, focal asymmetry, calcification, and architectural distortion...
October 3, 2016: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
Mark Sak, Neb Duric, Peter Littrup, Lisa Bey-Knight, Haythem Ali, Patricia Vallieres, Mark E Sherman, Gretchen L Gierach
A population of 165 women with negative mammographic screens also received an ultrasound tomography (UST) examination at the Karmanos Cancer Institute in Detroit, MI. Standard statistical techniques were employed to measure the associations between the various mammographic- and UST-related density measures and various participant characteristics such as age, weight and height. The mammographic percent density (MPD) was found to have similar strength associations with UST mean sound speed (Spearman coefficient, rs = 0...
September 29, 2016: Ultrasound in Medicine & Biology
Marta Cecilia Busana, Amanda Eng, Rachel Denholm, Mitch Dowsett, Sarah Vinnicombe, Steve Allen, Isabel Dos-Santos-Silva
BACKGROUND: Full-field digital mammography, which is gradually being introduced in most clinical and screening settings, produces two types of images: raw and processed. However, the extent to which mammographic density measurements, and their ability to predict breast cancer risk, vary according to type of image is not fully known. METHODS: We compared the performance of the semi-automated Cumulus method on digital raw, "analogue-like" raw and processed images, and the performance of a recently developed method - Laboratory for Breast Radiodensity Assessment (LIBRA) - on digital raw and processed images, in a case-control study (414 patients (cases) and 684 controls) by evaluating the extent to which their measurements were associated with breast cancer risk factors, and by comparing their ability to predict breast cancer risk...
September 26, 2016: Breast Cancer Research: BCR
Aimilia Gastounioti, Emily F Conant, Despina Kontos
BACKGROUND: The assessment of a woman's risk for developing breast cancer has become increasingly important for establishing personalized screening recommendations and forming preventive strategies. Studies have consistently shown a strong relationship between breast cancer risk and mammographic parenchymal patterns, typically assessed by percent mammographic density. This paper will review the advancing role of mammographic texture analysis as a potential novel approach to characterize the breast parenchymal tissue to augment conventional density assessment in breast cancer risk estimation...
2016: Breast Cancer Research: BCR
Fredrik Strand, Keith Humphreys, Mikael Eriksson, Jingmei Li, Therese Ml Andersson, Sven Törnberg, Edward Azavedo, John Shepherd, Per Hall, Kamila Czene
Interval breast cancer (IC) has a more aggressive phenotype and higher mortality than screen-detected cancer (SDC). In this case-case study, we investigated whether the size of longitudinal fluctuations in mammographic percent density (PD fluctuation) was associated with the ratio of IC vs. SDC among screened women with breast cancer. The primary study population consisted of 1,414 postmenopausal breast cancer cases, and the validation population of 1,241 cases. We calculated PD fluctuation as the quadratic mean of deviations between actual PD and the long-term trend estimated by a mixed effects model...
September 12, 2016: International Journal of Cancer. Journal International du Cancer
Abra M Jeffers, Weiva Sieh, Jafi A Lipson, Joseph H Rothstein, Valerie McGuire, Alice S Whittemore, Daniel L Rubin
Purpose To compare three metrics of breast density on full-field digital mammographic (FFDM) images as predictors of future breast cancer risk. Materials and Methods This institutional review board-approved study included 125 women with invasive breast cancer and 274 age- and race-matched control subjects who underwent screening FFDM during 2004-2013 and provided informed consent. The percentage of density and dense area were assessed semiautomatically with software (Cumulus 4.0; University of Toronto, Toronto, Canada), and volumetric percentage of density and dense volume were assessed automatically with software (Volpara; Volpara Solutions, Wellington, New Zealand)...
September 5, 2016: Radiology
Cecilia W Huo, Dexing Huang, Grace L Chew, Prue Hill, Ambika Vohora, Wendy V Ingman, Danielle J Glynn, Nathan Godde, Michael A Henderson, Erik W Thompson, Kara L Britt
Women with high mammographic density (MD) are at increased risk of breast cancer (BC) after adjustment for age and body mass index. We have developed a murine biochamber model in which both high MD (HMD) and low MD (LMD) tissue can be propagated. Here, we tested whether cells isolated by collagenase digestion and fluorescence-activated cell sorting (FACS) from normal breast can be reconstituted in our biochamber model, which would allow cell-specific manipulations to be tested. Fresh breast tissue was collected from women (n = 7) undergoing prophylactic mastectomy...
November 2016: Cell Biology International
Jingmei Li, Emma Ivansson, Daniel Klevebring, Nicholas P Tobin, Linda S Lindström, Johanna Holm, Gabriela Prochazka, Camilla Cristando, Juni Palmgren, Sven Törnberg, Keith Humphreys, Johan Hartman, Jan Frisell, Mattias Rantalainen, Johan Lindberg, Per Hall, Jonas Bergh, Henrik Grönberg, Kamila Czene
PURPOSE: Interval breast cancer is of clinical interest as it exhibits an aggressive phenotype and evades detection by screening mammography. A comprehensive picture of somatic changes that drive tumors to become symptomatic in the screening interval can improve understanding of the biology underlying these aggressive tumors. EXPERIMENTAL DESIGN: Initiated in April 2013, Clinical Sequencing of Cancer in Sweden (Clinseq) is a scientific and clinical platform for the genomic profiling of cancer...
September 1, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Jennifer Gillman, Jennifer Chun, Shira Schwartz, Freya Schnabel, Linda Moy
PURPOSE: The purpose was to evaluate the relationship between body mass index (BMI), mammographic breast density, magnetic resonance (MR) background parenchymal enhancement (BPE), and MR fibroglandular tissue (FGT) in women with breast cancer. METHODS: Our institutional database was queried for patients with preoperative mammography and breast MR imaging. RESULTS: There were 573 women eligible for analysis. Elevated BMI was associated with advanced stage of disease (P=...
August 12, 2016: Clinical Imaging
Amina Amadou, Carine Biessy, Sabina Rinaldi, Veronika Fedirko, Nada Assi, Martin Lajous, Eduardo Ortiz-Panozo, Elsa Yunes, Ruy Lopez-Ridaura, Gabriela Torres-Mejia, Isabelle Romieu
Low circulating levels of vitamin D and high mammographic density (MD) have been associated with higher risk of breast cancer. Although some evidence suggested an inverse association between circulating vitamin D and MD, no studies have investigated this association among Mexican women. We examined whether serum 25-hydroxyvitamin D3 [25(OH)D3] levels were associated with MD in a cross-sectional study nested within the large Mexican Teacher's Cohort. This study included 491 premenopausal women with a mean age of 42...
2016: PloS One
Qingsu Cheng, Cemal Cagatay Bilgin, Gerald Fontenay, Hang Chang, Matthew Henderson, Ju Han, Bahram Parvin
No abstract text is available yet for this article.
2016: Scientific Reports
Ashley S Felix, Petra Lenz, Ruth M Pfeiffer, Stephen M Hewitt, Jennifer Morris, Deesha A Patel, Berta Geller, Pamela M Vacek, Donald L Weaver, Rachael E Chicoine, John Shepherd, Amir Pasha Mahmoudzadeh, Jeff Wang, Bo Fan, Serghei Malkov, Sally D Herschorn, Jason M Johnson, Renata L Cora, Louise A Brinton, Mark E Sherman, Gretchen L Gierach
BACKGROUND: Women with high levels of mammographic density (MD) have a four- to six-fold increased risk of developing breast cancer; however, most neither have a prevalent tumor nor will they develop one. Magnetic resonance imaging (MRI) studies suggest that background parenchymal enhancement, an indicator of vascularity, is related to increased breast cancer risk. Correlations of microvessel density (MVD) in tissue, MD and biopsy diagnosis have not been defined, and we investigated these relationships among 218 women referred for biopsy...
2016: Breast Cancer Research: BCR
Leslie V Farland, Rulla M Tamimi, A Heather Eliassen, Donna Spiegelman, Kimberly A Bertrand, Stacey A Missmer
PURPOSE: Endometriosis and mammographic density have been hypothesized to be influenced by sex steroid hormonal exposures in adolescence and early adulthood. We investigated the association between endometriosis and mammographic density, a consistent and independent risk factor for breast cancer. METHODS: We conducted a cross-sectional analysis among 1,581 pre- and postmenopausal women not previously diagnosed with breast cancer in the Nurses' Health Study II cohort...
October 2016: Cancer Causes & Control: CCC
S J Zhang, M Z He, L L Zheng, Y J Gu, W J Peng
OBJECTIVE: To analyze the mammographic, MRI, and clinicopathological characteristics of primary breast lymphoma (PBL). METHODS: Clinicopathological characteristics were retrospectively reviewed and analyzed in 32 patients with histopathologically proven PBL. All cases were female (mean age, 50 years; median age 46 years; range, 30-68 years). RESULTS: In the 32 cases, there were bilateral tumors in 5 cases and 27 cases of unilateral involvement...
July 2016: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
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