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https://www.readbyqxmd.com/read/27918846/soy-food-intake-and-biomarkers-of-breast-cancer-risk-possible-difference-in-asian-women
#1
Gertraud Maskarinec, Dan Ju, Yukiko Morimoto, Adrian A Franke, Frank Z Stanczyk
Soy foods may protect against breast cancer in Asian but not in Western populations. We examined if the levels of various markers of breast cancer risk and inflammation, as well as the effects of soy food consumption on these markers, differ between Asian and non-Asian premenopausal women in two soy intervention trials. One study randomized 220 women to a 2-yr intervention and the other one randomized 96 women in a crossover design to examine the effects of consumption of 2 daily soy servings on nipple aspirate fluid (NAF) volume; estrogens in serum, NAF, and urine; insulin-like growth factor-1 (IGF-1), IGF-binding protein 3, and inflammatory markers in serum; and mammographic densities...
December 5, 2016: Nutrition and Cancer
https://www.readbyqxmd.com/read/27906044/high-mammographic-breast-density-predicts-locoregional-recurrence-after-modified-radical-mastectomy-for-invasive-breast-cancer-a-case-control-study
#2
Yu-Sen Huang, Jenny Ling-Yu Chen, Chiun-Sheng Huang, Sung-Hsin Kuo, Fu-Shan Jaw, Yao-Hui Tseng, Wei-Chun Ko, Yeun-Chung Chang
BACKGROUND: We aimed to evaluate the influence of mammographic breast density at diagnosis on the risk of cancer recurrence and survival outcomes in patients with invasive breast cancer after modified radical mastectomy. METHODS: This case-control study included 121 case-control pairs of women diagnosed with invasive breast cancer between 2004 and 2009, and who had undergone modified radical mastectomy and had mammographic breast density measured before or at diagnosis...
December 1, 2016: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/27902535/urinary-cadmium-and-mammographic-density
#3
Scott V Adams, John M Hampton, Amy Trentham-Dietz, Ronald E Gangnon, Martin M Shafer, Polly A Newcomb
No abstract text is available yet for this article.
January 2017: Epidemiology
https://www.readbyqxmd.com/read/27895758/metaplastic-carcinoma-of-the-breast-imaging-and-pathological-features
#4
Tiantian Bian, Qing Lin, Zengjie Wu, Chunxiao Cui, Chunhua Qi, Li Li, Xiaohui Su
Metaplastic carcinoma of the breast is a rare form of breast cancer. The aim of the present study was to investigate the imaging and pathological features of metaplastic carcinoma. The features identified on mammography and sonography were retrospectively reviewed in 13 women with metaplastic carcinoma of the breast. The results from the mammographs and sonographs were additionally evaluated using immunohistochemical staining for the expression of the estrogen receptor (ER) and progesterone receptor (PR), receptor tyrosine-protein kinase erbB-2 (CerbB-2) and P53...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27894075/mammographic-density-a-potential-monitoring-biomarker-for-adjuvant-and-preventative-breast-cancer-endocrine-therapies
#5
REVIEW
Michael S Shawky, Hilary Martin, Honor J Hugo, Thomas Lloyd, Kara L Britt, Andrew Redfern, Erik W Thompson
Increased mammographic density (MD) has been shown beyond doubt to be a marker for increased breast cancer risk, though the underpinning pathobiology is yet to be fully elucidated. Estrogenic activity exerts a strong influence over MD, which consequently has been observed to change predictably in response to tamoxifen anti-estrogen therapy, although results for other selective estrogen receptor modulators and aromatase inhibitors are less consistent. In both primary and secondary prevention settings, tamoxifen-associated MD changes correlate with successful modulation of risk or outcome, particularly among pre-menopausal women; an observation that supports the potential use of MD change as a surrogate marker where short-term MD changes reflect longer-term anti-estrogen efficacy...
November 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27882030/association-between-25-hydroxy-vitamin-d-and-volumetric-breast-density-via-a-fully-automated-software-volpara%C3%A2-in-the-reproductive-age-group
#6
Bushra Wasim, Khalid Khan, Mohd Abdul Samad
OBJECTIVE: To determine the association between serum 25 hydroxyvitamin D levels and percent breast density among asymptomatic premenopausal women. METHODS: Hundred asymptomatic, pre-menopausal women who visited the General Surgery Breast Clinic, Patel Hospital, Karachi, Pakistan between 3rd March and 10th November, 2015 were included in this study. The serum 25 (OH)D and calcium levels were measured and mammographic density (MD) was assessed using automated volumetric breast density software, Volpara Research (algorithm version 1...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27864652/differences-in-mammographic-density-between-asian-and-caucasian-populations-a-comparative-analysis
#7
Nadia Rajaram, Shivaani Mariapun, Mikael Eriksson, Jose Tapia, Pui Yoke Kwan, Weang Kee Ho, Faizah Harun, Kartini Rahmat, Kamila Czene, Nur Aishah Mohd Taib, Per Hall, Soo Hwang Teo
PURPOSE: Mammographic density is a measurable and modifiable biomarker that is strongly and independently associated with breast cancer risk. Paradoxically, although Asian women have lower risk of breast cancer, studies of minority Asian women in predominantly Caucasian populations have found that Asian women have higher percent density. In this cross-sectional study, we compared the distribution of mammographic density for a matched cohort of Asian women from Malaysia and Caucasian women from Sweden, and determined if variations in mammographic density could be attributed to population differences in breast cancer risk factors...
November 18, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27863982/predictors-of-breast-cancer-worry-in-a-hispanic-and-predominantly-immigrant-mammography-screening-population
#8
Ayana April-Sanders, Sabine Oskar, Rachel C Shelton, Karen M Schmitt, Elise Desperito, Angeline Protacio, Parisa Tehranifar
OBJECTIVE: Worry about developing breast cancer (BC) worry has been associated with participation in screening and genetic testing and with follow-up of abnormal screening results. Little is known about the scope and predictors of BC worry in Hispanic and immigrant populations. METHODS: We collected in-person interview data from 250 self-identified Hispanic women recruited from an urban mammography facility (average age 50.4 years; 82% foreign-born). Women reported whether they worried about developing breast cancer rarely/never (low worry), sometimes (moderate worry), or often/all the time (high worry)...
November 15, 2016: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/27860535/is-there-an-association-between-bone-mineral-density-and-mammographic-density-a-systematic-review
#9
Jong Min Lee, Susan Holley, Catherine Appleton, Adetunji T Toriola
INTRODUCTION: Both bone mineral density (BMD) and breast density are related to reproductive hormone levels. This suggests that BMD and breast density could be meaningfully associated, and serve as surrogate markers for breast cancer risk. However, few studies have investigated the association of BMD with percent mammographic density, making it difficult to draw meaningful conclusions. MATERIALS AND METHODS: We conducted a systematic review of studies published in electronic databases till April 2016 using the following search terms: "bone density," "bone mineral density," "mammographic breast density," "breast density," and "mammographic density...
November 18, 2016: Journal of Women's Health
https://www.readbyqxmd.com/read/27853653/dense-breast-tissue-in-postmenopausal-women-is-associated-with-a-pro-inflammatory-microenvironment-in-vivo
#10
Annelie Abrahamsson, Anna Rzepecka, Thobias Romu, Magnus Borga, Olof Dahlqvist Leinhard, Peter Lundberg, Johan Kihlberg, Charlotta Dabrosin
Inflammation is one of the hallmarks of carcinogenesis. High mammographic density has been associated with increased risk of breast cancer but the mechanisms behind are poorly understood. We evaluated whether breasts with different mammographic densities exhibited differences in the inflammatory microenvironment. Postmenopausal women attending the mammography-screening program were assessed having extreme dense, n = 20, or entirely fatty breasts (nondense), n = 19, on their regular mammograms. Thereafter, the women were invited for magnetic resonance imaging (MRI), microdialysis for the collection of extracellular molecules in situ and a core tissue biopsy for research purposes...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27845552/breast-angiosarcoma-with-exophytic-growth
#11
Donya Farrokh, Elaheh Modoodi, Yalda Fallah Rastegar
Primary angiosarcoma of the breast is a rare malignant tumor. Diagnostic breast imaging includes mammography and ultrasound, which are usually nonspecific. A 42-year-old woman with angiosarcoma of the breast is presented. Physical findings showed a hard exophytic mass in the upper part of the left breast, with skin discoloration overlaying the mass. Mammography revealed a high density well defined mass in the left breast, without any micro-calcification and speculation. On ultrasound examination, a hypoechoic mass with a well-defined margin and heterogenous echogenicity was detected...
November 2016: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/27832519/automatic-estimation-of-volumetric-breast-density-using-artificial-neural-network-based-calibration-of-full-field-digital-mammography-feasibility-on-japanese-women-with-and-without-breast-cancer
#12
Jeff Wang, Fumi Kato, Hiroko Yamashita, Motoi Baba, Yi Cui, Ruijiang Li, Noriko Oyama-Manabe, Hiroki Shirato
Breast cancer is the most common invasive cancer among women and its incidence is increasing. Risk assessment is valuable and recent methods are incorporating novel biomarkers such as mammographic density. Artificial neural networks (ANN) are adaptive algorithms capable of performing pattern-to-pattern learning and are well suited for medical applications. They are potentially useful for calibrating full-field digital mammography (FFDM) for quantitative analysis. This study uses ANN modeling to estimate volumetric breast density (VBD) from FFDM on Japanese women with and without breast cancer...
November 10, 2016: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/27832382/diabetes-diabetes-treatment-and-mammographic-density-in-danish-diet-cancer-and-health-cohort
#13
Karsten Buschard, Katrin Thomassen, Elsebeth Lynge, Ilse Vejborg, Anne Tjønneland, My von Euler-Chelpin, Zorana Jovanovic Andersen
PURPOSE: We examined whether diabetes and diabetes treatment are associated with MD in a cohort study of Danish women above age of 50 years. METHODS: Study cohort consisted of 5,644 women (4,500 postmenopausal) who participated in the Danish Diet, Cancer, and Health cohort (1993-1997) and subsequently attended mammographic screening in Copenhagen (1993-2001). We used MD assessed at the first screening after the cohort entry, defined as mixed/dense or fatty. Diabetes diagnoses and diabetes treatments (diet, insulin, or oral antidiabetic agents) were self-reported at the time of recruitment (1993-1997)...
November 10, 2016: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/27824483/using-volumetric-breast-density-to-quantify-the-potential-masking-risk-of-mammographic-density
#14
Stamatia Destounis, Lisa Johnston, Ralph Highnam, Andrea Arieno, Renee Morgan, Ariane Chan
OBJECTIVE: The purposes of this study were to compare BI-RADS density categories with quantitative volumetric breast density (VBD) for the reporting of mammographic sensitivity and to identify which patient factors are most predictive of a diagnosis of interval cancer of the breast versus screen-detected cancer. MATERIALS AND METHODS: This retrospective study included screen-detected cancers (n = 652) and interval cancers (n = 119) identified between January 2009 and December 2012...
November 8, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27814827/radiologist-agreement-for-mammographic-recall-by-case-difficulty-and-finding-type
#15
Tracy Onega, Megan Smith, Diana L Miglioretti, Patricia A Carney, Berta A Geller, Karla Kerlikowske, Diana S M Buist, Robert D Rosenberg, Robert A Smith, Edward A Sickles, Sebastien Haneuse, Melissa L Anderson, Bonnie Yankaskas
PURPOSE: The aim of this study was to assess agreement of mammographic interpretations by community radiologists with consensus interpretations of an expert radiology panel to inform approaches that improve mammographic performance. METHODS: From 6 mammographic registries, 119 community-based radiologists were recruited to assess 1 of 4 randomly assigned test sets of 109 screening mammograms with comparison studies for no recall or recall, giving the most significant finding type (mass, calcifications, asymmetric density, or architectural distortion) and location...
November 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27814818/digital-breast-tomosynthesis-utilization-in-the-united-states-a-survey-of-physician-members-of-the-society-of-breast-imaging
#16
Lara A Hardesty, Sarah M Kreidler, Deborah H Glueck
PURPOSE: To assess utilization of digital breast tomosynthesis (DBT) and examine criteria for offering DBT to patients. METHODS: We created an online survey for physician members of the Society of Breast Imaging to assess their use of DBT. The questions covered availability of DBT at the participant's practice, whether DBT was used for clinical care or research, clinical decision rules guiding patient selection for DBT, costs associated with DBT, plans to obtain DBT, and breast imaging practice characteristics...
November 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27806715/prognostic-contribution-of-mammographic-breast-density-and-her2-overexpression-to-the-nottingham-prognostic-index-in-patients-with-invasive-breast-cancer
#17
Amro Masarwah, Päivi Auvinen, Mazen Sudah, Vaiva Dabravolskaite, Otso Arponen, Anna Sutela, Sanna Oikari, Veli-Matti Kosma, Ritva Vanninen
BACKGROUND: To investigate whether very low mammographic breast density (VLD), HER2, and hormone receptor status holds any prognostic significance within the different prognostic categories of the widely used Nottingham Prognostic Index (NPI). We also aimed to see whether these factors could be incorporated into the NPI in an effort to enhance its performance. METHODS: This study included 270 patients with newly diagnosed invasive breast cancer. Patients with mammographic breast density of <10 % were considered as VLD...
November 2, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27806604/breast-parenchymal-patterns-in-processed-versus-raw-digital-mammograms-a-large-population-study-toward-assessing-differences-in-quantitative-measures-across-image-representations
#18
Aimilia Gastounioti, Andrew Oustimov, Brad M Keller, Lauren Pantalone, Meng-Kang Hsieh, Emily F Conant, Despina Kontos
PURPOSE: With raw digital mammograms (DMs), which retain the relationship with x-ray attenuation of the breast tissue, not being routinely available, processed DMs are often the only viable means to acquire imaging measures. The authors investigate differences in quantitative measures of breast density and parenchymal texture, shown to have value in breast cancer risk assessment, between the two DM representations. METHODS: The authors report data from 8458 pairs of bilateral raw ("FOR PROCESSING") and processed ("FOR PRESENTATION") DMs acquired from 4278 women undergoing routine screening evaluation, collected with DM units from two different vendors...
November 2016: Medical Physics
https://www.readbyqxmd.com/read/27776557/mammographically-dense-human-breast-tissue-stimulates-mcf10dcis-com-progression-to-invasive-lesions-and-metastasis
#19
Cecilia W Huo, Mark Waltham, Christine Khoo, Stephen B Fox, Prue Hill, Shou Chen, Grace L Chew, John T Price, Chau H Nguyen, Elizabeth D Williams, Michael Henderson, Erik W Thompson, Kara L Britt
BACKGROUND: High mammographic density (HMD) not only confers a significantly increased risk of breast cancer (BC) but also is associated with BCs of more advanced stages. However, it is unclear whether BC progression and metastasis are stimulated by HMD. We investigated whether patient-derived HMD breast tissue could stimulate the progression of MCF10DCIS.com cells compared with patient-matched low mammographic density (LMD) tissue. METHODS: Sterile breast specimens were obtained immediately after prophylactic mastectomy from high-risk women (n = 10)...
October 25, 2016: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/27746121/focal-breast-pain-does-breast-density-affect-the-need-for-ultrasound
#20
Michael W Cho, Lars J Grimm, Karen S Johnson
RATIONALE AND OBJECTIVES: This study aimed to determine the utility of directed ultrasound and digital mammogram for evaluating focal breast pain in women with different mammographic breast densities. MATERIALS AND METHODS: This institutional review board-approved and Health Insurance Portability and Accountability Act-compliant retrospective study included 413 cases of focal breast pain in 369 women (mean age 53 years). All cases were evaluated with both mammogram and ultrasound and had at least 2 years of imaging follow-up...
October 13, 2016: Academic Radiology
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