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mammographic density

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https://www.readbyqxmd.com/read/29144164/correlation-between-obesity-and-fat-infiltrated-axillary-lymph-nodes-visualized-on-mammography
#1
Roberta Maria M diFlorio Alexander, Steffen J Haider, Todd MacKenzie, Martha E Goodrich, Julie Weiss, Tracy Onega
OBJECTIVE: Using screening mammography, this study investigated the association between obesity and axillary lymph node (LN) size and morphology. METHODS: We conducted a retrospective review of 188 women who underwent screening mammography at an academic medical center. Length and width of the LN and hilum were measured in the largest, mammographically visible axillary node. The hilo-cortical ratio (HCR) was calculated as the hilar width divided by the cortical width...
November 16, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29140420/growth-trajectories-breast-size-and-breast-tissue-composition-in-a-british-pre-birth-cohort-of-young-women
#2
Rachel Denholm, Bianca De Stavola, John H Hipwell, Simon J Doran, Marta C Busana, Martin O Leach, David J Hawkes, Isabel Dos-Santos-Silva
Mammographic % density, the proportion of fibroglandular tissue in the breast, is a strong risk factor for breast cancer, but its determinants in young women are unknown. We examined associations between magnetic resonance imaging (MRI) breast-tissue composition at age 21 years and prospectively-collected measures of body size and composition from birth to early adulthood, and markers of puberty (all standardized), in a sample of 500 nulliparous women from a pre-birth cohort of children born in Avon, England, in 1991-1992 and followed up to 2011-2014...
November 13, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29139590/breast-density-in-screening-mammography-in-indian-population-is-it-different-from-western-population
#3
Tulika Singh, Niranjan Khandelwal, Veenu Singla, Dileep Kumar, Madhu Gupta, Gurpreet Singh, Amanjit Bal
Mammography is the only method presently considered appropriate for mass screening of breast cancer. However, higher breast density was strongly associated with lower mammographic sensitivity. Breast density is also identified as independent and strongest risk factors for breast cancer. Studies have shown women with high breast density have four to six times increased risk of breast cancer as compare to women with fatty breast. It varies between different age group it generally decreases with increasing age in postmenopausal women and it can be different in different ethnic groups and people from different geographical areas...
November 15, 2017: Breast Journal
https://www.readbyqxmd.com/read/29103360/modelling-breast-cancer-tumour-growth-for-a-stable-disease-population
#4
Gabriel Isheden, Keith Humphreys
Statistical models of breast cancer tumour progression have been used to further our knowledge of the natural history of breast cancer, to evaluate mammography screening in terms of mortality, to estimate overdiagnosis, and to estimate the impact of lead-time bias when comparing survival times between screen detected cancers and cancers found outside of screening programs. Multi-state Markov models have been widely used, but several research groups have proposed other modelling frameworks based on specifying an underlying biological continuous tumour growth process...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29098437/breast-compression-parameters-and-mammographic-density-in-the-norwegian-breast-cancer-screening-programme
#5
Nataliia Moshina, Marta Roman, Gunvor G Waade, Sofie Sebuødegård, Giske Ursin, Solveig Hofvind
OBJECTIVES: To investigate possible associations between breast compression parameters, including compression force, pressure and compressed breast thickness, and mammographic density assessed by an automated software. METHODS: We obtained data on breast compression parameters, breast volume, absolute and percentage dense volume, and body mass index for 14,698 women screened with two-view (craniocaudal, CC, and mediolateral oblique, MLO) digital mammography, in the Norwegian Breast Cancer Screening Programme, 2014-2015...
November 2, 2017: European Radiology
https://www.readbyqxmd.com/read/29097444/razor-a-phase-ii-open-randomized-trial-of-screening-plus-goserelin-and-raloxifene-versus-screening-alone-in-pre-menopausal-women-at-increased-risk-of-breast-cancer
#6
Anthony Howell, Linda Ashcroft, Lesley Fallowfield, Diana M Eccles, Rosalind A Eeles, Ann Ward, Adam R Brentnall, Mitchell Dowsett, Jack M Cuzick, Rosemary Greenhalgh, Caroline Boggis, Jamie Motion, Jamie C Sergeant, Judith Adams, D Gareth R Evans
BACKGROUND: Ovarian suppression in premenopausal women is known to reduce breast cancer risk. This study aimed to assess uptake and compliance with ovarian suppression using the LHRH analogue, goserelin, with add-back raloxifene, as a potential regimen for breast cancer prevention. METHODS: Women at ≥30% lifetime risk breast cancer were approached and randomized to mammographic screening alone(C-Control) or screening in addition to monthly subcutaneous injections of 3...
November 2, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29091007/harms-of-restrictive-risk-based-mammographic-breast-cancer-screening
#7
Colleen H Neal, W Tania Rahman, Annette I Joe, Mitra Noroozian, Renee W Pinsky, Mark A Helvie
OBJECTIVE: The objective of this study was to determine if restrictive risk-based mammographic screening could miss breast cancers that population-based screening could detect. MATERIALS AND METHODS: Through a retrospective search of records at a single institution, we identified 552 screen-detected breast cancers in 533 patients. All in situ and invasive breast cancers detected at screening between January 1, 2011, and December 31, 2014, were included. Medical records were reviewed for history, pathology, cancer size, nodal status, breast density, and mammographic findings...
November 1, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29074552/occupational-exposures-and-mammographic-density-in-spanish-women
#8
Virginia Lope, Javier García-Pérez, Beatriz Pérez-Gómez, Ana María Pedraza-Flechas, Juan Alguacil, Mª Carmen González-Galarzo, Miguel Angel Alba, Rudolf van der Haar, Rosa Ana Cortés-Barragán, Carmen Pedraz-Pingarrón, Pilar Moreo, Carmen Santamariña, María Ederra, Carmen Vidal, Dolores Salas-Trejo, Carmen Sánchez-Contador, Rafael Llobet, Marina Pollán
OBJECTIVES: The association between occupational exposures and mammographic density (MD), a marker of breast cancer risk, has not been previously explored. Our objective was to investigate the influence of occupational exposure to chemical, physical and microbiological agents on MD in adult women. METHODS: This is a population-based cross-sectional study based on 1476 female workers aged 45-65 years from seven Spanish breast cancer screening programmes. Occupational history was surveyed by trained staff...
October 26, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29072403/inconsistencies-of-breast-cancer-risk-factors-between-the-northern-and-southern-regions-of-vietnam
#9
Phuong Dung (Yun) Trieu, Claudia Mello-Thoms, Jennifer K Peat, Thuan Doan Do, Patrick C Brennan
Background: In recent decades the amount of new breast cancer cases in the southern region has been reported to increase more rapidly than in the northernVietnam. The aim of this study is to compare breast cancer risk factors between the two regions and establish if westernized influences have an impact on any reported differences. Method: Data was collected from the two largest oncology hospitals in the north and the south of Vietnam in 2015. Breast density, demographic, reproductive and lifestyle data of 127 cases and 269 controls were collected in the north and 141 cases and 250 controls were gathered from the south...
October 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29071592/detection-and-segmentation-of-pectoral-muscle-on-mlo-view-mammogram-using-enhancement-filter
#10
P S Vikhe, V R Thool
The presence of predominant density region of the pectoral muscle in Medio-Lateral Oblique (MLO) view of the mammograms can affect or bias the results of mammograms processing for breast cancer detection using intensity based methods. Therefore, to improve the diagnostic performance of breast cancer detection using computer-aided system, identification and segmentation of pectoral muscle is an important task. This paper presents, an intensity based approach to identify the pectoral region in mammograms. In the presented approach enhancement mask and threshold technique is used to enhance and select the pectoral region and boundary points respectively, to find the boundary of pectoral muscle...
October 25, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/29047382/a-novel-and-fully-automated-mammographic-texture-analysis-for-risk-prediction-results-from-two-case-control-studies
#11
Chao Wang, Adam R Brentnall, Jack Cuzick, Elaine F Harkness, D Gareth Evans, Susan Astley
BACKGROUND: The percentage of mammographic dense tissue (PD) is an important risk factor for breast cancer, and there is some evidence that texture features may further improve predictive ability. However, relatively little work has assessed or validated textural feature algorithms using raw full field digital mammograms (FFDM). METHOD: A case-control study nested within a screening cohort (age 46-73 years) from Manchester UK was used to develop a texture feature risk score (264 cases diagnosed at the same time as mammogram of the contralateral breast, 787 controls) using the least absolute shrinkage and selection operator (LASSO) method for 112 features, and validated in a second case-control study from the same cohort but with cases diagnosed after the index mammogram (317 cases, 931 controls)...
October 18, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29047034/quantitative-volumetric-k-means-cluster-segmentation-of-fibroglandular-tissue-and-skin-in-breast-mri
#12
Anton Niukkanen, Otso Arponen, Aki Nykänen, Amro Masarwah, Anna Sutela, Timo Liimatainen, Ritva Vanninen, Mazen Sudah
Mammographic breast density (MBD) is the most commonly used method to assess the volume of fibroglandular tissue (FGT). However, MRI could provide a clinically feasible and more accurate alternative. There were three aims in this study: (1) to evaluate a clinically feasible method to quantify FGT with MRI, (2) to assess the inter-rater agreement of MRI-based volumetric measurements and (3) to compare them to measurements acquired using digital mammography and 3D tomosynthesis. This retrospective study examined 72 women (mean age 52...
October 18, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29040039/breast-cancer-risk-associations-with-digital-mammographic-density-by-pixel-brightness-threshold-and-mammographic-system
#13
Tuong L Nguyen, Yoon-Ho Choi, Ye K Aung, Christopher F Evans, Nhut H Trinh, Shuai Li, Gillian S Dite, Myeong-Seong Kim, Patrick C Brennan, Mark A Jenkins, Joohon Sung, Yun-Mi Song, John L Hopper
Purpose To compare three mammographic density measures defined by different pixel intensity thresholds as predictors of breast cancer risk for two different digital mammographic systems. Materials and Methods The Korean Breast Cancer Study included 398 women with invasive breast cancer and 737 control participants matched for age at mammography (±1 year), examination date, mammographic system, and menopausal status. Mammographic density was measured by using the automated Laboratory for Individualized Breast Radiodensity Assessment (LIBRA) software and the semiautomated Cumulus software at the conventional threshold (Cumulus) and at increasingly higher thresholds (Altocumulus and Cirrocumulus, respectively)...
October 16, 2017: Radiology
https://www.readbyqxmd.com/read/28985925/improving-performance-of-breast-cancer-risk-prediction-by-incorporating-optical-density-image-feature-analysis-an-assessment
#14
Shiju Yan, Yunzhi Wang, Faranak Aghaei, Yuchen Qiu, Bin Zheng
RATIONALE AND OBJECTIVES: The purpose of this study is to improve accuracy of near-term breast cancer risk prediction by applying a new mammographic image conversion method combined with a two-stage artificial neural network (ANN)-based classification scheme. MATERIALS AND METHODS: The dataset included 168 negative mammography screening cases. In developing and testing our new risk model, we first converted the original grayscale value (GV)-based mammographic images into optical density (OD)-based images...
October 3, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28965910/mammographic-parenchymal-pattern-and-breast-cancer-risk-profile-of%C3%A2-papua-new-guinean-women-a-baseline-study-of-the-screening-population
#15
R Pape, K Spuur, P Umo
INTRODUCTION: The aim of this research is to evidence for the first time the breast density of Papua New Guinean (PNG) women as described by mammographic parenchymal patterns (MPPs) and profile breast cancer risk; to examine the relationship of age and MPPs. METHODS: A retrospective analysis of 1161 screening mammograms of women who had undergone imaging at the Pacific International Hospital (PIH) was undertaken. Mammograms were classified into one of five Tabár MPPs; age was recorded in years...
November 2017: Radiography
https://www.readbyqxmd.com/read/28965898/a-self-directed-learning-intervention-for-radiographers-rating-mammographic-breast-density
#16
E U Ekpo, P Hogg, E Wasike, M F McEntee
PURPOSE: Subjective methods of mammographic breast density (MBD) assessment are prone to inter-reader variability. This work aims to assess the impact of a short self-directed, experiential learning intervention on radiographers' reproducibility of MBD assessment. METHOD: The study used two sets of images (test and learning intervention) containing left craniocaudal and left mediolateral oblique views. The test set had MBD ratings from Volpara™ and radiologists using the fourth edition Breast Imaging and Data Systems (BI-RADS(®))...
November 2017: Radiography
https://www.readbyqxmd.com/read/28965165/alcohol-consumption-and-mammographic-density-in-the-danish-diet-cancer-and-health-cohort
#17
Katja Kemp Jacobsen, Elsebeth Lynge, Anne Tjønneland, Ilse Vejborg, My von Euler-Chelpin, Zorana J Andersen
PURPOSE: We examined the association between alcohol consumption and mammographic density (MD) considering in detail the time of exposure and the type of alcohol. METHODS: Of 5,356 women (4,489 post-menopausal) from the Danish Diet, Cancer and Health cohort (1993-1997) who attended mammographic screening in Copenhagen (1993-2001), we used MD (mixed/dense or fatty) assessed at the first screening after cohort entry. Alcohol consumption was assessed at the time of recruitment...
September 30, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28964442/evaluation-of-a-stratified-national-breast-screening-program-in-the-united-kingdom-an-early-model-based-cost-effectiveness-analysis
#18
Ewan Gray, Anna Donten, Nico Karssemeijer, Carla van Gils, D Gareth Evans, Sue Astley, Katherine Payne
OBJECTIVES: To identify the incremental costs and consequences of stratified national breast screening programs (stratified NBSPs) and drivers of relative cost-effectiveness. METHODS: A decision-analytic model (discrete event simulation) was conceptualized to represent four stratified NBSPs (risk 1, risk 2, masking [supplemental screening for women with higher breast density], and masking and risk 1) compared with the current UK NBSP and no screening. The model assumed a lifetime horizon, the health service perspective to identify costs (£, 2015), and measured consequences in quality-adjusted life-years (QALYs)...
September 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28957821/association-between-mammographic-density-and-tumor-marker-defined-breast-cancer-subtypes-a-case-control-study
#19
Jinyoung Shin, Jeong Eon Lee, Hyeon Young Ko, Tuong Linh Nguyen, Seok Jin Nam, John Llewelyn Hopper, Yun-Mi Song
High mammographic density (MD) is the most important risk factor for breast cancer. This study aimed to clarify the relationship between MD and breast cancer subtypes defined by tumor markers. We enrolled 642 women with breast cancer (69% premenopausal) and 1241 controls matched for age and menopausal status. Absolute mammographic dense area (ADA), percent mammographic dense area (PDA), and nondense area were assessed using a computer-assisted thresholding technique. We classified breast cancer cases into four subtypes using information on tumor marker expression such as estrogen receptor (ER), progesterone receptor (PR), and Cerb2 receptor (HER2); luminal A (ER+ and/or PR+, HER2-), luminal B (ER+ and/or PR+, HER2+), HER2-overexpressing (ER-, PR-, and HER2+), and triple-negative (ER-, PR-, and HER2-)...
September 27, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28952021/mammographic-appearances-in-mongolia-causal-factors-for-varying-densities
#20
D Demchig, C Mello-Thoms, Kh Khulan, A Ramish, P C Brennan
Objective: Mammographic density (MD) is a significant risk factor for breast cancer and an important determinant for establishing efficiency of any screening program. Currently, the distribution and influential factors of MD is unknown among Mongolian women. This work aims to characterize MD of Mongolian women. Methods: The ethical approval was obtained from Research Ethics Board of the University of Sydney (2014/973) and National Ethic Committee from Ministry of Mongolia (2015/04). We recruited 1985 women aged 16-83 from the National Cancer Center in Mongolia for whom MD and age of each woman was known...
September 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
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