keyword
https://read.qxmd.com/read/37909618/effect-of-a-combination-of-gliptin-and-metformin-on-serum-vitamin-b12-folic-acid-and-ferritin-levels
#1
JOURNAL ARTICLE
Fevziye Turkoglu Genc, Ahmet Nalbant, Ahmed Cihad Genc, Tezcan Kaya
OBJECTIVE: The primary objective of this study was to explore the impact of metformin and metformin/gliptin combination therapy on the serum concentrations of vitamin B12, ferritin, and folic acid in individuals diagnosed with type 2 diabetes. METHODS: This study included 118 patients, classified into two groups: 59 patients using only metformin and 59 patients using a combination of metformin/gliptin. Among the latter group, 35 patients used vildagliptin/metformin, and 24 used sitagliptin/metformin...
2023: Revista da Associação Médica Brasileira
https://read.qxmd.com/read/37570832/insight-into-structure-activity-relationship-of-dpp-4-inhibitors-for-development-of-antidiabetic-agents
#2
REVIEW
Vishal Mathur, Ozair Alam, Nadeem Siddiqui, Mukund Jha, Ajay Manaithiya, Sandhya Bawa, Naveen Sharma, Sultan Alshehri, Prawez Alam, Faiyaz Shakeel
This article sheds light on the various scaffolds that can be used in the designing and development of novel synthetic compounds to create DPP-4 inhibitors for the treatment of type 2 diabetes mellitus (T2DM). This review highlights a variety of scaffolds with high DPP-4 inhibition activity, such as pyrazolopyrimidine, tetrahydro pyridopyrimidine, uracil-based benzoic acid and esters, triazole-based, fluorophenyl-based, glycinamide, glycolamide, β-carbonyl 1,2,4-triazole, and quinazoline motifs. The article further explains that the potential of the compounds can be increased by substituting atoms such as fluorine, chlorine, and bromine...
August 3, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37544280/gliptins-normalize-posttraumatic-hippocampal-neurogenesis-and-restore-cognitive-function-after-controlled-cortical-impact-on-sensorimotor-cortex
#3
JOURNAL ARTICLE
Yu-Wen Hung, Guan-Ling Lu, Hwei-Hsien Chen, Hsiu-Hui Tung, Sheau-Ling Lee
Traumatic brain injury (TBI) often leads to long-term neurocognitive dysfunctions. Adult neurogenesis in the hippocampal dentate gyrus (DG) serves critical functions in cognition but can be disrupted by brain injury and insult in serval forms. In the present study, we explore the cellular and molecular targets of DPP-4 inhibitors (or gliptins) as related to hippocampal function and TBI cognitive sequelae. Two structurally different gliptins, sitagliptin and vildagliptin, were examined using a controlled cortical impact (CCI) model of moderate TBI in mice...
August 4, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/37510747/non-specific-inhibition-of-dipeptidyl-peptidases-8-9-by-dipeptidyl-peptidase-4-inhibitors-negatively-affects-mesenchymal-stem-cell-differentiation
#4
JOURNAL ARTICLE
Bárbara Torrecillas-Baena, Marta Camacho-Cardenosa, José Manuel Quesada-Gómez, Paloma Moreno-Moreno, Gabriel Dorado, María Ángeles Gálvez-Moreno, Antonio Casado-Díaz
DPP4 may play a relevant role in MSC differentiation into osteoblasts or adipocytes. Dipeptidyl peptidase 4 (DPP4) inhibitors (DPP4i), such as sitagliptin and vildagliptin, are used as antidiabetic drugs. However, vildagliptin is not a specific DPP4i and also inhibits DPP8/9, which is involved in energy metabolism and immune regulation. The aim of this study is to evaluate how sitagliptin, vildagliptin or 1G244 (a DPP8/9 specific inhibitor) may influence cell viability, as well as osteogenic and adipogenic differentiation in human mesenchymal stem cells (MSC)...
July 12, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37326010/pharmacologic-heterogeneity-and-risk-of-severe-hypoglycemia-with-concomitant-use-of-sulfonylureas-and-dpp-4-inhibitors-population-based-cohort-study
#5
JOURNAL ARTICLE
Jenny Dimakos, Ying Cui, Robert W Platt, Christel Renoux, Kristian B Filion, Antonios Douros
Dipeptidyl peptidase-4 inhibitors (DPP-4i) interact with sulfonylureas to increase their risk of hypoglycemia. Our population-based study assessed whether intraclass pharmacologic heterogeneity among sulfonylureas (long- vs. short-acting) and DPP-4i (peptidomimetic vs. non-peptidomimetic) modifies this interaction. We conducted a cohort study using the UK's Clinical Practice Research Datalink Aurum linked to hospitalization and vital statistics data. We assembled a cohort of patients initiating sulfonylureas (2007-2020)...
September 2023: Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/37235347/molecular-characterization-and-functional-analysis-of-the-dipeptidyl-peptidase-iv-from-venom-of-the-ectoparasitoid-scleroderma-guani
#6
JOURNAL ARTICLE
Chaoyan Wu, Cheng Yang, Yuqin Wang, Jun Wang, Jiaying Zhu
Dipeptidyl peptidase IV (DPPIV) is a proline-specific serine peptidase that remains poorly investigated in terms of venom composition. Here, we describe the molecular characteristics and possible functions of DPPIV as a major venom component of the ant-like bethylid ectoparasitoid, Scleroderma guani , named SgVnDPPIV. The SgVnDPPIV gene was cloned, which encodes a protein with the conserved catalytic triads and substrate binding sites of mammalian DPPIV. This venom gene is highly expressed in the venom apparatus...
April 27, 2023: Toxins
https://read.qxmd.com/read/37232153/finding-the-most-cost-effective-option-from-commonly-used-dipeptidyl-peptidase-4-inhibitors-in-india-a-systematic-study
#7
JOURNAL ARTICLE
Harmanjit Singh, Ekta Arora, Seerat Narula, Mandeep Singla, Armaan Otaal, Jatin Sharma
OBJECTIVE: To identify a preferred and cost-effective drug among Dipeptidyl peptidase-4 inhibitors (DPP4Is) for Indian patients with T2DM. METHODS: We performed a systematic literature search using standard databases for relevant literature. Original studies comparing the efficacy and/or safety of different DPP4Is were included. Two authors independently performed the literature search, screening, and collected relevant data from the selected studies. The costs of all brands of individual DPP4Is were noted and compared for lowest, highest, and average cost...
May 26, 2023: Expert Review of Endocrinology & Metabolism
https://read.qxmd.com/read/37011023/simultaneous-analysis-of-antihyperglycemic-small-molecule-drugs-and-peptide-drugs-by-means-of-dual-liquid-chromatography-high-resolution-mass-spectrometry
#8
JOURNAL ARTICLE
Aline C Vollmer, Lea Wagmann, Armin A Weber, Markus R Meyer
OBJECTIVES: The study aimed to evaluate dual liquid chromatography (LC) coupled to high-resolution mass spectrometry (HRMS) for the simultaneous analysis of small and large molecule drugs by development and application of a validated bioanalytical method. METHODS: The oral antihyperglycemic drugs (OAD) dapagliflozin, empagliflozin, glibenclamide, glimepiride, metformin, pioglitazone, repaglinide, saxagliptin, sitagliptin, and vildagliptin, as well as the antihyperglycemic peptides exenatide, human insulin, insulin aspart, insulin degludec, insulin detemir, insulin glargine, insulin glulisine, insulin lispro, and semaglutide were included in the analytical procedure...
April 4, 2023: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/36909158/hypoglycemic-medicines-in-the-treatment-of-alzheimer-s-disease-pathophysiological-links-between-ad-and-glucose-metabolism
#9
REVIEW
Yixuan Wang, Hao Hu, Xinyu Liu, Xiangyu Guo
Alzheimer's Disease (AD) is a global chronic disease in adults with beta-amyloid (Aβ) deposits and hyperphosphorylated tau protein as the pathologic characteristics. Although the exact etiology of AD is still not fully elucidated, aberrant metabolism including insulin signaling and mitochondria dysfunction plays an important role in the development of AD. Binding to insulin receptor substrates, insulin can transport through the blood-brain barrier (BBB), thus mediating insulin signaling pathways to regulate physiological functions...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/36897510/risk-heterogeneity-of-bullous-pemphigoid-among-dipeptidyl-peptidase-4-inhibitors-a-population-based-cohort-study-using-japanese-latter-stage-elderly-healthcare-database
#10
JOURNAL ARTICLE
Yumi Harano, Yasutaka Mitamura, Peng Jiang, Takako Fujita, Akira Babazono
AIMS/INTRODUCTION: Although the association between dipeptidyl peptidase-4 (DPP-4) inhibitors and bullous pemphigoid (BP) has begun to be established, some studies have suggested there are risk differences among DPP-4 inhibitors. We conducted a population-based cohort study to examine the risk differences. MATERIALS AND METHODS: Using the claims databases of the Fukuoka Prefecture Wide-Area Association of Latter-Stage Elderly Healthcare between April 1, 2013 and March 31, 2017, we conducted a retrospective cohort study to compare patients receiving one DPP-4 inhibitor with those who were prescribed another antidiabetic drug...
March 10, 2023: Journal of Diabetes Investigation
https://read.qxmd.com/read/36830597/dipeptidyl-peptidase-4-inhibitor-sitagliptin-phosphate-accelerates-cellular-cholesterol-efflux-in-thp-1-cells
#11
JOURNAL ARTICLE
Tomohiro Komatsu, Satomi Abe, Shihoko Nakashima, Kei Sasaki, Yasuki Higaki, Keijiro Saku, Shin-Ichiro Miura, Yoshinari Uehara
Cholesterol efflux is a major atheroprotective function of high-density lipoproteins (HDLs) which removes cholesterol from the foam cells of lipid-rich plaques in Type 2 diabetes. The dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin phosphate increases plasma glucagon-like peptide-1 (GLP-1) concentrations and is used to treat Type 2 diabetes. GLP-1 plays an important role in regulating insulin secretion and expression via the GLP-1 receptor (GLP-1R), which is expressed in pancreatic islets as well as freshly isolated human monocytes and THP-1 cells...
January 24, 2023: Biomolecules
https://read.qxmd.com/read/36669855/-impact-of-direction-of-transport-on-the-evaluation-of-substrate-recognition-of-mouse-multidrug-and-toxin-extrusion-protein-1-mmate1
#12
JOURNAL ARTICLE
Asami Saito, Tomoko Kito, Naoki Ishiguro, Masahito Takatani, Takashi Kudo, Bojan Bister, Hiroyuki Kusuhara
Multidrug and toxin extrusion protein (MATE/SLC47A) secretes metabolites and xenobiotics into the urine in the proximal tubules of the kidney. Uptake assays have been commonly used for evaluating MATE-mediated transport of new chemical entities in drug development. The purpose of this study was to examine the relationship between in vitro uptake activities by MATEs and the impact of MATE-mediated transport in in vivo renal secretion. In vitro uptake in mouse Mate1- (mMate1) expressing HEK293 cells and several in vivo parameters from mMate1 knockout and wild type mice were compared using nine cationic compounds (almotriptan, naratriptan, talinolol, sumatriptan, alogliptin, sitagliptin, rivaroxaban, saxagliptin, and vildagliptin)...
January 20, 2023: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://read.qxmd.com/read/36637688/comparison-of-adverse-events-occurred-during-administration-of-dipeptidyl-peptidase-4-inhibitor-in-patients-with-diabetes-using-fda-adverse-event-reporting-system
#13
JOURNAL ARTICLE
Toru Ogura, Chihiro Shiraishi
BACKGROUND AND OBJECTIVE: Various dipeptidyl peptidase-4 (DPP-4) inhibitors have been approved for the treatment of diabetes. The frequencies of known serious side effects might differ among DPP-4 inhibitors, therefore a large sample size is needed to study them in prospective clinical trials. We examined the adverse events that occurred during the administration of a DPP-4 inhibitor in patients with diabetes using FDA Adverse Event Reporting System (FAERS) data. METHODS: We used FAERS data reported between January 2013 and March 2022 in patients with diabetes who received a DPP-4 inhibitor...
January 13, 2023: Clinical Drug Investigation
https://read.qxmd.com/read/36555387/the-influence-of-lifestyle-and-treatment-on-oxidative-stress-and-inflammation-in-diabetes
#14
REVIEW
Magdalena Wronka, Julia Krzemińska, Ewelina Młynarska, Jacek Rysz, Beata Franczyk
Diabetes is considered a new pandemic of the modern world, and the number of sufferers is steadily increasing. Sustained hyperglycemia promotes the production of free radicals and leads to persistent, low-grade inflammation. Oxidative stress causes mitochondrial destruction, which along with activation of the hexosamine pathway, nuclear factor-κB (Nf-κb), p38 mitogen-activated protein kinase (p38 MAPK), c-jun NH2 terminal kinase/stress-activated protein kinase (JNK/SAPK) or toll-like receptors (TLRs), leads to pancreatic β-cell dysfunction...
December 12, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36366967/inverse-association-between-dpp-4-inhibitor-use-and-fracture-in-older-adults-a-disproportionality-analysis-of-the-faers-and-jader
#15
JOURNAL ARTICLE
Katsuhiro Ohyama, Takumi Okamoto, Yusuke Hori
OBJECTIVE: Fractures are significantly associated with increased morbidity and mortality in older individuals; additionally, patients with diabetes mellitus are highly prone to fractures. The aim of the present study was to examine the association between dipeptidyl peptidase-4 (DPP-4) inhibitor use and the risk of fracture in older patients by analyzing data obtained from spontaneous adverse event reporting databases from the United States and Japan. MATERIALS AND METHODS: Data on older patients registered in the U...
November 11, 2022: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/36342972/longitudinal-assessment-of-the-quality-of-life-and-patterns-of-antidiabetic-medication-use-in-patients-with-type-2-diabetes-saudi-arabia-perspective-discover-study
#16
JOURNAL ARTICLE
Khalid Al-Rubeaan, Faisal Banah, Fayez G Alruwaily, Eman Sheshah, Dhekra Alnaqeb, Awad M AlQahtani, Diaa Ewais, Nassr Al Juhani, Abdul-Hameed Hassan, Amira M Youssef
Objectives: Patients with type 2 diabetes nowadays have a wide range of new antidiabetic medications with better efficacy and safety. Physicians' attitude toward selecting antidiabetic medications to reach targeted glycemic control and better quality-of-life (QOL) has not been studied prospectively. The global DISCOVER study aims to comprehensively provide a real-world assessment of the treatment pattern changes for patients with type 2 diabetes, in addition to QOL assessment. The Kingdom of Saudi Arabia was one of the countries participating in the DISCOVER study program...
November 7, 2022: Current Medical Research and Opinion
https://read.qxmd.com/read/36304224/bullous-pemphigoid-associated-with-dipeptidyl-peptidase-4-inhibitors-for-the-treatment-of-type-2-diabetes-a-multicenter-study-in-istanbul
#17
JOURNAL ARTICLE
Ece Ugurer, Ezgi Ozkur, Ilknur Kivanc Altunay, Esra Cil Sen, Ayse Esra Koku Aksu, Ilknur Ozcan, Yuksel Altuntas, Mehmet Salih Gurel
Objectives: Recent studies have revealed an association between dipeptidyl peptidase 4 inhibitors (DPP4i) and development of bullous pemphigoid (BP). The main aim of our study is to evaluate the association between DPP4i treatment and BP development. The secondary endpoints were to evaluate clinical characteristics and biochemical parameters of the DPP4i associated BP cases and determine the differences of DPP4i associated BP disease than non-DPP4i associated BP cases. Methods: We designed a retrospective case-control study, comparing type 2 diabetic 58 BP cases to 75 type 2 diabetic controls...
2022: Şişli Etfal Hastanesi tıp bülteni
https://read.qxmd.com/read/36077491/incretins-as-a-potential-treatment-option-for-gestational-diabetes-mellitus
#18
REVIEW
Aleksandra Pilszyk, Magdalena Niebrzydowska, Zuzanna Pilszyk, Magdalena Wierzchowska-Opoka, Żaneta Kimber-Trojnar
Gestational diabetes mellitus (GDM) is a metabolic disease affecting an increasing number of pregnant women around the world. It is not only associated with numerous perinatal complications but also has long-term consequences impacting maternal health and fetal development. To prevent them, it is important to keep glucose levels under control. As much as 15-30% of GDM patients will require treatment with insulin, metformin, or glyburide. With that in mind, it is crucial to keep searching for novel and improved pharmacotherapies...
September 3, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/35813300/a-clinical-decision-support-system-for-diabetes-patients-with-deep-learning-experience-of-a-taiwan-medical-center
#19
JOURNAL ARTICLE
Ting-Ying Chien, Hsien-Wei Ting, Chih-Fang Chen, Cheng-Zen Yang, Chong-Yi Chen
Background: Diabetes mellitus (DM) is a major public health problem worldwide. It involves dysfunction of blood sugar regulation resulting from insulin resistance, inadequate insulin secretion, or excessive glucagon secretion. Methods: This study collated 971,401 drug usage records of 51,009 DM patients. These data include patient identification code, age, gender, outpatient visiting dates, visiting code, medication features (included items, doses, and frequencies of drugs), HbA1c results, and testing time...
2022: International Journal of Medical Sciences
https://read.qxmd.com/read/35716545/development-of-a-new-lc-ms-ms-method-for-the-simultaneous-identification-and-quantification-of-13-antidiabetic-drugs-in-human-hair
#20
JOURNAL ARTICLE
Nadia Arbouche, Jean-Sébastien Raul, Pascal Kintz
Oral antidiabetics are the drugs used to control blood sugar in diabetic subjects. The greatest risk of using these drugs is hypoglycaemia, which can be fatal if managed inappropriately. The diagnosis of hypoglycemia may be simple in diabetic subjects but can become a challenge in subjects with no history of exposure to these drugs. The major interest of testing for these compounds in hair is in the case of unexpected hypoglycaemias, as it enables discrimination between hypoglycaemias caused by antidiabetics and other reasons (e...
June 10, 2022: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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