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carcinoma of the rectum

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https://www.readbyqxmd.com/read/28725246/effects-of-vaginal-cylinder-position-on-dose-distribution-in-patients-with-endometrial-carcinoma-in-treatment-of-vaginal-cuff-brachytherapy
#1
Yurday Ozdemir, Yemliha Dolek, Cem Onal
PURPOSE: To investigate the impact of different cylinder positions on dosimetry of critical structures in patients with endometrial carcinoma undergoing three-dimensional image-based vaginal cuff brachytherapy (VCB). MATERIAL AND METHODS: We delivered VCB at a dose of 4 Gy to a depth of 5 mm in the vaginal cuff of 15 patients using three different cylinder positions (neutral [N], parallel [P], and angled [A]) according to the longitudinal axis of the patient. We analyzed the dose-volume distribution and volumetric variability of the rectum and bladder...
June 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28711649/intramucosal-colorectal-carcinoma-with-invasion-of-the-lamina-propria-a-study-by-the-japanese-society-for-cancer-of-the-colon-and-rectum
#2
Motohiro Kojima, Hideyuki Shimazaki, Keiichi Iwaya, Takahiro Nakamura, Hiroshi Kawachi, Kazuhito Ichikawa, Shigeki Sekine, Shingo Ishiguro, Tadakazu Shimoda, Ryoji Kushima, Takashi Yao, Takahiro Fujimori, Kazuo Hase, Toshiaki Watanabe, Kenichi Sugihara, Gregory Y Lauwers, Atsushi Ochiai
Cancer invasion of the lamina propria is an important pathological finding. However, the clinicopathologic features and diagnostic accuracy of intramucosal carcinoma assessment in colorectal carcinoma (CRC) are unknown. In this study, intramucosal CRCs were reviewed in institutions affiliated with the Japanese Society for Cancer of the Colon and Rectum, and 32 cases with invasion of the lamina propria were identified. Next, a consensus meeting was held to select cases with a high consensus about the presence of invasion, which were reviewed by one Western pathologist for confirmation...
July 12, 2017: Human Pathology
https://www.readbyqxmd.com/read/28711481/simultaneous-integrated-boost-sib-for-treatment-of-gynecologic-carcinoma-intensity-modulated-radiation-therapy-imrt-vs-volumetric-modulated-arc-therapy-vmat-radiotherapy
#3
Irina Vergalasova, Kim Light, Junzo Chino, Oana Craciunescu
The aim of this study was to quantitatively compare dosimetric criteria between intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) plans for patients undergoing radiation treatment of gynecologic carcinoma with a simultaneous integrated boost (SIB) technique. IMRT and VMAT plans were retrospectively analyzed for 20 patients. The elective volume was planned to receive 45 Gy in 25 fractions of 1.8 Gy, with the integrated boost volume (involved nodes) receiving 55 Gy simultaneously...
July 12, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28705205/clinicopathological-features-and-prognosis-of-gastroenteropancreatic-neuroendocrine-neoplasms-in-a-chinese-population-a-large-retrospective-single-centre-study
#4
Meng Zhang, Ping Zhao, Xiaodan Shi, Ahong Zhao, Lianfeng Zhang, Lin Zhou
BACKGROUND: Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are the most common type of neuroendocrine tumors, accounting for more than half of neuroendocrine neoplasms (NENs). We performed a retrospective study in our center to investigate the clinicopathological features, risk factors of metastasis, and prognosis of GEP-NENs in a Chinese population. METHODS: Four hundred forty patients with GEP-NENs treated at the First Affiliated Hospital of Zhengzhou University between January 2011 and March 2016 were analyzed retrospectively...
July 13, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28690772/bladder-urothelial-carcinoma-extending-to-rectal-mucosa-and-presenting-with-rectal-bleeding
#5
Andrew M Aneese, Vinayata Manuballa, Mitual Amin, Mitchell S Cappell
An 87-year-old-man with prostate-cancer-stage-T1c-Gleason-6 treated with radiotherapy in 1996, recurrent prostate cancer treated with leuprolide hormonal therapy in 2009, and bladder-urothelial-carcinoma in situ treated with Bacillus-Calmette-Guerin and adriamycin in 2010, presented in 2015 with painless, bright red blood per rectum coating stools daily for 5 mo. Rectal examination revealed bright red blood per rectum; and a hard, fixed, 2.5 cm × 2.5 cm mass at the normal prostate location. The hemoglobin was 7...
June 16, 2017: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28690492/interval-squamous-cell-carcinoma-of-the-rectum
#6
Daryl Ramai, Kinesh Changela, Jonathan Lai, Ghulamullah Shahzad, Madhavi Reddy
Squamous cell carcinoma (SCC) of the rectum is a rare clinical entity with an incidence rate of 0.1-0.25% per 1,000 cases. Though its etiology and pathogenesis remains unclear, it has been associated with chronic inflammation and infections. Herein, we report a case of an 82-year-old female who presented with a 2-month history of worsening abdominal pain, hematochezia, and bilateral inguinal lymphadenopathy with right-sided purulent discharge. Two years prior, she had had an unremarkable screening colonoscopy which met all quality indicators...
May 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28668495/toward-standardization-of-laparoscopic-resection-for-colorectal-cancer-in-developing-countries-a-step-by-step-module
#7
Ahmed Mostafa Ahmed Mahmoud, Manar Mohamed Moneer
BACKGROUND: Despite the proven benefits, laparoscopic colorectal surgery is still underutilized among surgeons especially in developing countries. Also a steep learning is one of the causes of its limited adoption. OBJECTIVE: To explore the learning curve of single surgeon experience in laparoscopic colectomy and feasibility of implementing a well standardized step by step operative technique to overcome the beginning technical obstacles. PATIENTS AND METHODS: This prospective study included 50 patients with carcinoma of the left colon and rectum recruited from the department of surgical oncology at National Cancer Institute, Cairo University in the period 2012-2016...
June 28, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28658872/mri-evaluation-of-local-extent-of-carcinoma-cervix-is-post-contrast-imaging-needed-in-every-case
#8
Joish Upendra Kumar, Ramireddy Harikiran Reddy, Pallavi Sinha, Niveditha Kodali, Vivek Sreekanth
INTRODUCTION: Carcinoma cervix is widely prevalent among women in developing countries. Post contrast Magnetic Resonance Imaging (MRI) utilising spin echo T1 weighted sequence with fat suppression is widely practiced as part of evaluation of carcinoma cervix. However, it is unclear if such post contrast imaging provides any additional information other than adding to the cost of imaging. AIM: To find accuracy of T1 and T2 weighted non contrast MRI protocol in comparison with post contrast spin echo T1 weighted fat suppressed imaging in evaluating the local extent of the carcinoma cervix...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28657837/mckittrick-wheelock-syndrome-treated-by-transanal-minimally-invasive-surgery-a-single-center-experience-and-review-of-the-literature
#9
Anne Elisabeth Maria van der Pool, Eelco Jan Rade de Graaf, Maarten Vermaas, Renée Martine Barendse, Pascal Gabriël Doornebosch
INTRODUCTION: McKittrick Wheelock Syndrome (MKWS) is a rare syndrome characterized by secretory diarrhea, dehydration, prerenal acute kidney injury, and severe electrolyte abnormalities caused by a large hypersecretory villous adenoma located in the rectum or rectosigmoid junction. Transabdominal (laparoscopic) procedures are the most described procedures in the treatment of MKWS. We report an alternative surgical approach, transanal minimally invasive surgery (TAMIS), to solve this syndrome...
June 28, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28649123/extraovarian-primary-peritoneal-carcinomatosis-a-case-report
#10
Gregory Nicolas, Tony Kfoury, Hassan Fawaz, Mahdi Issa
BACKGROUND Extraovarian primary peritoneal carcinoma (EOPPC) is a rare malignant epithelial tumor with an age-adjusted incidence rate of 6.78 per million, which arises from the peritoneal lining with minimal or no ovarian involvement. EOPPC is a diagnosis of exclusion with the absence of other identifiable primary sites and after surgical assessment and consideration of the histological report to evaluate the extent of ovarian invasion. CASE REPORT A 66-year-old woman complained of mild postprandial epigastric pain...
June 26, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28644145/colorectal-carcinoma-with-osseous-metaplasia
#11
Xibo Liu, Jinghong Xu, Lirong Chen
Osseous metaplasia (OM) is rarely observed in colorectal cancer (incidence < 0.4% in rectal cancer), where it has a non-specific clinical presentation and unknown pathogenesis. Here, we report three cases of colorectal carcinoma with OM and propose a new hypothesis. All three patients (two males and one female) were Chinese and had different sites of colorectal carcinoma with OM: rectum, sigmoid colon, and appendix. The pathologic diagnoses were serrated adenocarcinoma; moderately to poorly differentiated adenocarcinoma with micropapillary carcinoma and cribriform comedo-type adenocarcinoma; and mucinous adenocarcinoma, respectively...
June 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28637502/clinicopathologic-characteristics-and-prognosis-of-gastroenteropancreatic-neuroendocrine-neoplasms-a-multicenter-study-in-south-china
#12
Cheng Fang, Wei Wang, Yu Zhang, Xingyu Feng, Jian Sun, Yujie Zeng, Ye Chen, Yong Li, Minhu Chen, Zhiwei Zhou, Jie Chen
BACKGROUND: Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are a heterogeneous group of rare tumors. Many issues in terms of epidemiologic features, pathogenesis, and treatment of GEP-NENs are still under discussion. Our study aimed to analyze the clinicopathologic characteristics and prognosis of Chinese patients with GEP-NENs. METHODS: Complete clinicopathologic data and survival information of 1183 patients with GEP-NENs treated between 2005 and 2015 were collected from five medical centers in Guangdong Province, China...
June 21, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28633725/well-differentiated-neuroendocrine-tumor-a-low-b-grade-tumor-s-aggressive-course-and-dismal-outcome-a-case-report
#13
Dinesh Atwal, Krishna Prasad Joshi, Susanne Jeffus, James Ntambi, Fade Mahmoud
INTRODUCTION: Incidence of well-differentiated neuroendocrine tumors (NETs) of the colon and rectum is increasing and is now approximately 1 per 100,000 in the US. NETs are either well-differentiated (indolent) or poorly differentiated (aggressive). The majority of these tumors are found incidentally during screening colonoscopies and rarely are associated with symptoms of hormonal syndrome, even during the advanced stage. Metastatic well-differentiated NETs of the colon and rectum are incurable, hard to treat, and associated with a poor prognosis and survival rates similar to colorectal adenocarcinoma survival...
2017: Permanente Journal
https://www.readbyqxmd.com/read/28633587/sarcomatoid-carcinoma-manifesting-as-recurrent-rectal-cancer-and-mimicking-radiation-induced-extraskeletal-osteosarcoma-a-case-report
#14
MiJo Lee, Hyun-Jin Son, Je-Ho Jang, Hyun-Young Han, Moon Hyang Park
Here, we report an unusual case of sarcomatoid carcinoma mimicking extraskeletal osteosarcoma that manifested as recurrent rectal cancer. Five years earlier, a 76-year-old male patient had undergone neoadjuvant chemoradiotherapy followed by a laparoscopic low anterior resection due to adenocarcinoma of the rectum. He was admitted because of pain in the anus and left hip. He underwent abdominal computed tomography that revealed a newly developed left perirectal mass with gluteus maximus invasion measuring up to 8 cm, and therefore, an abdominoperineal resection was performed...
June 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28631649/chlamydia-trachomatis-proctitis-masquerading-as-carcinoma-rectum-first-case-report-from-india
#15
Benu Dhawan, Govind Kumar Makharia, Deepak Juyal, Sujeesh Sebastian, Riti Bhatia, Neena Khanna
While proctitis is caused both by infectious and noninfectious causes, infectious causes are acquired typically sexually. Chlamydia trachomatis, which is the most frequent bacterial pathogen causing sexually transmitted infections worldwide, is one of the causative agents of proctitis. We report a case history of a bisexual male who presented to us with rectal bleeding. The colonoscopy showed a nodular ulcerated lesion in the rectum suggestive of rectal malignancy, but biopsies from rectal mass did not reveal malignancy...
April 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28607598/the-prognostic-value-of-tyrosine-kinase-src-expression-in-locally-advanced-rectal-cancer
#16
Felix Rühlmann, Manuel Nietert, Thilo Sprenger, Hendrik A Wolff, Kia Homayounfar, Peter Middel, Hanibal Bohnenberger, Tim Beissbarth, B Michael Ghadimi, Torsten Liersch, Lena-Christin Conradi
The cellular sarcoma gene (SRC) is a proto-oncogene encoding for a tyrosine kinase. SRC expression was determined in locally advanced rectal adenocarcinoma tissue from pretreatment biopsies and resection specimens. The expression level was correlated with clinicopathological parameters to evaluate the predictive and prognostic capacity. For this monocentric analysis 186 patients with locally advanced rectal cancer (median: 63.7 years; 130 men (69.9%), 56 women (30.1%)) were included. Patients with a carcinoma of the upper third of the rectum were treated with primary tumor resection (n=27; 14...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28599468/clinical-significance-of-coagulation-factors-in-operable-colorectal-cancer
#17
Suee Lee, Seok Jae Huh, Sung Yong Oh, Myeong Seok Koh, Sung-Hyun Kim, Ji Hyun Lee, Jin Young Han, Hong Jo Choi, Su Jin Kim, Hyo-Jin Kim
Abnormal hemostasis in cancer patients has prev iously been studied. The primary objective of the present study was to evaluate the association between preoperative hemostasis markers and clinicopathological parameters, and to identify a hemostasis marker affecting survival in patients following curative resection for colorectal cancer. A total of 170 patients who underwent curative surgery for colorectal carcinoma were evaluated. Preoperative coagulation tests included platelet, prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, D-dimer and fibrinogen degradation product (FDP)...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28578828/complete-resection-of-locally-advanced-ovarian-carcinoma-fixed-to-the-pelvic-sidewall-and-involving-external-and-internal-iliac-vessels
#18
Kyoko Nishikimi, Shinichi Tate, Ayumu Matsuoka, Makio Shozu
OBJECTIVE: Locally advanced ovarian carcinomas may be fixed to the pelvic sidewall, and although these often involve the internal iliac vessels, they rarely involve the external iliac vessels. Such tumors are mostly considered inoperable. We present a surgical technique for complete resection of locally advanced ovarian carcinoma fixed to the pelvic sidewall and involving external and internal iliac vessels. METHODS: A 69-year-old woman presented with ovarian carcinoma fixed to the right pelvic sidewall, which involved the right external and internal iliac arteries and veins and the right lower ureter, rectum, and vagina...
June 1, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28576262/total-laparoscopic-pelvic-exenteration-for-a-laterally-recurrent-cervical-carcinoma-with-a-vesicovaginal-fistula-that-developed-after-concurrent-chemoradiotherapy
#19
Hiroyuki Kanao, Yoichi Aoki, Tsuyoshi Hisa, Nobuhiro Takeshima
OBJECTIVE: For locally advanced cervical carcinoma, concurrent chemoradiotherapy (CCRT) is the standard treatment, however, CCRT can lead to development of a vesicovaginal or rectovaginal fistula [1]. Treatment options are limited for patients with laterally recurrent cervical carcinoma and fistula formation after CCRT. Chemotherapy with bevacizumab is now used for recurrent or advanced cervical carcinoma, but this treatment is associated with fistula formation [2]. When the recurrent mass is confined to the pelvic cavity, complete surgical resection with negative margins offers the most promise; however, the resectability rate is low in cases of laterally recurrent tumor [3], which may include bony structures, and survival outcomes seem to be poor in cases of a laterally recurrent vs...
May 30, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28567332/successful-radiotherapy-for-advanced-small-cell-carcinoma-of-the-prostate-with-syndrome-of-inappropriate-secretion-of-antidiuretic-hormone
#20
Masanari Fukasawa, Norifumi Sawada, Hiroshi Shimura, Tatsuya Ihara, Satoru Kira, Hidenori Zakoji, Takahiko Mitsui, Masayuki Takeda
Small cell carcinoma of the prostate (SCCP) is rare in clinical practice. It is often accompanied with the syndrome of inappropriate antidiuretic hormone secretion (SIADH). We present a case of SCCP with SIADH that was successfully treated with radiotherapy in the metastatic lymphnodes and prostate. The patient was an 81-year-old male with a castrate-resistant prostate cancer (CRPC) with invaded rectum and multiple metastases of pelvic lymphnodes. Hyponatremia was present. After radiotherapy, serum sodium increased and neuron-specific enolase (NSE) decreased...
July 2017: Urology Case Reports
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