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https://www.readbyqxmd.com/read/28930604/therapeutic-startegies-for-human-papillomavirus-infection-and-associated-cancers
#1
Alok Chandra Bharti, Tejveer Singh, Anjali Bhat, Deepti Pande, Mohit Jadli
Human papillomavirus (HPV) infection is linked to development of cancer of cervix, vagina, vulva, penis, ano-genital and non-genital oro-pharyngeal sites. HPV being a sexually transmitted virus infects both genders equally but with higher chances of pathological outcome in women. In the absence of organized screening programs, women report HPV-infected lesions at relatively advanced stages where they are subjected to standard treatments that are not HPV-specific. HPV infection-driven lesions usually take 10-20 years for malignant progression and are preceded by well-characterized pre-cancer stages...
January 1, 2018: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28921401/experience-with-curative-radiotherapy-for-cervix-cancer-in-the-bahamas-for-2006-2016
#2
Glenn Jones, Osama Kellini, Nevein Girgis, Darron Halliday, Raleigh Butler, Thomas McGowan, Conville Brown
BACKGROUND: Cervix cancer is a significant health problem. As access to quality care in Small Island Developing States improves, and cancer centers become established, providers of care can summarize local experience to benchmark system quality and look for ways to further improve value. METHODS: This is a retrospective study of all cases of cervix cancer managed 2006-2016 at The Cancer Centre Bahamas, in conjunction with Princess Margaret Hospital, Nassau, affiliated with The University of West Indies...
September 18, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28919095/laparoscopic-near-infrared-fluorescent-imaging-as-an-alternative-option-for-sentinel-lymph-node-mapping-in-endometrial-cancer-a-prospective-study
#3
Salih Taşkın, Yavuz Emre Şükür, Duygu Altın, Cevriye Cansız Ersöz, Batuhan Turgay, Duygu Kankaya, Mete Güngör, Fırat Ortaç
BACKGROUND: To evaluate feasibility of sentinel lymph node (SLN) mapping by using near-infrared fluorescent imaging and indocyanine green (NIR/ICG) integrated laparoscopic system in clinically uterine-confined endometrial cancer. MATERIALS AND METHODS: Patients with clinically early-stage endometrial cancer were included in this prospective study. ICG was injected to the uterine cervix and NIR/ICG integrated laparoscopic system (Spies Full HD D-Light P ICG technology, Karl Storz, Tuttlingen, Germany) was used during the operations...
September 14, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28913152/early-vulvar-and-umbilical-incisional-scar-recurrence-of-cervical-squamous-cell-carcinoma-earlier-than-usually-expected
#4
Hüseyin Çağlayan Özcan, Aynur Mustafa, Zehra Bozdağ, Seyhun Sucu, Mete Gürol Uğur, Özcan Balat
Cutaneous metastasis is considered as a hazardous condition depending on the mean survival around 9 months, which usually originates from cancers of the breast, lung, ovary, colon, and rarely from the cervix. The crucial prognostic factor of cutaneous metastasis depends on the period between the primary malignancy and cutaneous metastasis. We report two cases of the unusual presentation of squamous cell cancer of the cervix that developed vulvar and umbilical metastasis in the 5(th) month of primary treatment...
June 2017: Turk J Obstet Gynecol
https://www.readbyqxmd.com/read/28911828/laparoscopic-sentinel-lymph-node-mapping-with-indocyanine-green-icg-using-ispies-platform-the-initial-experience-in-argentina
#5
Julian Di Guilmi, Maria Cecilia Darin, Maria Toscano, Gustavo Maya
OBJECTIVE: To demonstrate the initial experience in Argentina using the iSpies ICG platform in performing sentinel lymph node mapping in early-stage cervical cancer. Design Step-by-step video and pictures BACKGROUND: Laparoscopic and robotic sentinel lymph node mapping using ICG has been shown to be safe and feasible. However, the use of fluorescent imaging through a minimally invasive approach in developing countries is very limited given the cost restrictions of acquiring the near infrared technology and the fluorescent dyes...
September 11, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28911064/cancer-mortality-predictions-for-2017-in-latin-america
#6
G Carioli, C La Vecchia, P Bertuccio, T Rodriguez, F Levi, P Boffetta, E Negri, M Malvezzi
Background: From most recent available data, we predicted cancer mortality statistics in selected Latin American countries for the year 2017, with focus on lung cancer. Materials and methods: We obtained death certification data from the World Health Organization and population data from the Pan American Health Organization database for all neoplasms and selected cancer sites. We derived figures for Argentina, Brazil, Chile, Colombia, Cuba, Mexico and Venezuela...
September 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28901517/cx32-inhibits-tnf%C3%AE-induced-extrinsic-apoptosis-with-and-without-egfr-suppression
#7
Yongchang Lai, Liang Tao, Yifan Zhao, Xiaomin Zhang, Xingjuan Sun, Qin Wang, Chengfang Xu
Tumor necrosis factor α (TNFα) and TNF-related apoptosis-inducing ligand (TRAIL) can trigger the extrinsic apoptosis pathway. Our previous study indicated that connexin32 (Cx32) inhibited streptonigrin-induced intrinsic apoptosis via the epidermal growth factor receptor (EGFR) pathway. However, whether Cx32 can exert effects on the extrinsic apoptosis pathway through EGFR signaling remains unclear. In the present study, we investigated the role of Cx32 in extrinsic apoptosis induced by treatment with TNFα + cycloheximide (CHX) or afatinib in human cervical cancer (CaCx) cells...
September 7, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28900466/can-an-inadequate-cervical-cytology-sample-in-thinprep-be-converted-to-a-satisfactory-sample-by-processing-it-with-a-surepath-preparation
#8
Sveinung Wergeland Sørbye, Mette Kristin Pedersen, Bente Ekeberg, Merete E Johansen Williams, Torill Sauer, Ying Chen
BACKGROUND: The Norwegian Cervical Cancer Screening Program recommends screening every 3 years for women between 25 and 69 years of age. There is a large difference in the percentage of unsatisfactory samples between laboratories that use different brands of liquid-based cytology. We wished to examine if inadequate ThinPrep samples could be satisfactory by processing them with the SurePath protocol. MATERIALS AND METHODS: A total of 187 inadequate ThinPrep specimens from the Department of Clinical Pathology at University Hospital of North Norway were sent to Akershus University Hospital for conversion to SurePath medium...
2017: CytoJournal
https://www.readbyqxmd.com/read/28893744/survival-after-bone-metastasis-by-primary-cancer-type-a-danish-population-based-cohort-study
#9
Elisabeth Svensson, Christian F Christiansen, Sinna P Ulrichsen, Mikael R Rørth, Henrik T Sørensen
OBJECTIVE: In the 10 most common primary types with bone metastases, we aimed to examine survival, further stratifying on bone metastases only or with additional synchronous metastases. METHODS: We included all patients aged 18 years and older with incident hospital diagnosis of solid cancer between 1994 and 2010, subsequently diagnosed with BM until 2012. We followed patients from date of bone metastasis diagnosis until death, emigration or 31 December 2012, whichever came first...
September 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28882511/-doses-to-organs-at-risk-for-conformational-and-stereotactic-radiotherapy-bladder
#10
L Duvergé, J Castelli, T Lizée, R de Crevoisier, D Azria
Bladder dose constraints in case of conformational radiotherapy/intensity-modulated radiotherapy and stereotactic radiotherapy are reported from the literature, in particular from the French radiotherapy society RECORAD recommendations, according to the treated pelvic tumor sites. The dose-volume effect on urinary toxicity is not clearly demonstrated, making difficult to establish absolute dose constraints for the bladder. In case of high-dose prostate cancer radiotherapy, the bladder dose constraints are: V60Gy<50% and maximum dose<80Gy for standard fractionation and V60Gy<5%, V48Gy<25% and V41Gy<50% for moderate hypofractionation (20 fractions of 3Gy)...
September 4, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28873443/application-of-carbon-nanoparticles-in-laparoscopic-sentinel-lymph-node-detection-in-patients-with-early-stage-cervical-cancer
#11
Yan Lu, Jin-Ying Wei, De-Sheng Yao, Zhong-Mian Pan, Yao Yao
OBJECTIVE: To investigate the value of carbon nanoparticles in identifying sentinel lymph nodes in early-stage cervical cancer. METHODS: From January 2014 to January 2016, 40 patients with cervical cancer stage IA2-IIA, based on the International Federation of Gynecology and Obstetrics (FIGO) 2009 criteria, were included in this study. The normal cervix around the tumor was injected with a total of 1 mL of carbon nanoparticles (CNP)at 3 and 9 o'clock. All patients then underwent laparoscopic pelvic lymph node dissection and radical hysterectomy...
2017: PloS One
https://www.readbyqxmd.com/read/28867617/total-reference-air-kerma-can-accurately-predict-isodose-surface-volumes-in-cervix-cancer-brachytherapy-a-multicenter-study
#12
Karen S Nkiwane, Else Andersen, Jerome Champoudry, Astrid de Leeuw, Jamema Swamidas, Jacob Lindegaard, Richard Pötter, Christian Kirisits, Kari Tanderup
PURPOSE: To demonstrate that V60 Gy, V75 Gy, and V85 Gy isodose surface volumes can be accurately estimated from total reference air kerma (TRAK) in cervix cancer MRI-guided brachytherapy (BT). METHODS AND MATERIALS: 60 Gy, 75 Gy, and 85 Gy isodose surface volumes levels were obtained from treatment planning systems (VTPS) for 239 EMBRACE study patients from five institutions treated with various dose rates, fractionation schedules and applicators. An equation for estimating VTPS from TRAK was derived...
August 31, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28866125/the-impact-of-using-electrical-impedance-spectroscopy-zedscan-on-the-performance-of-colposcopy-in-diagnosing-high-grade-squamous-lesions-of-the-cervix
#13
C Muszynski, E Dupont, B Vaysse, S Lanta, J Tidy, F Sergent, J Gondry
OBJECTIVES: To determine the efficacy of colposcopy plus ZedScan, which measures changes in tissue electrical impedance, for detecting intraepithelial high-grade lesions compared to colposcopy alone. METHODS: A prospective study conducted at a university hospital colposcopy clinic. Patients referred following abnormal cervical cytology or colposcopic follow up were examined by colposcopy plus ZedScan to assess the cervix. The results of ZedScan directed and colposcopically directed biopsies were compared...
August 30, 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28859123/prognostic-significance-of-the-co-expression-of-egfr-and-her2-in-adenocarcinoma-of-the-uterine-cervix
#14
Asako Ueda, Akira Takasawa, Taishi Akimoto, Kumi Takasawa, Tomoyuki Aoyama, Yoshihiko Ino, Masanori Nojima, Yusuke Ono, Masaki Murata, Makoto Osanai, Tadashi Hasegawa, Tsuyoshi Saito, Norimasa Sawada
Prognostic factors and therapeutic targets are needed for the patients with cervical adenocarcinoma because they have a poor prognosis. Recently, co-expression of multiple receptor tyrosine kinases (RTKs) has been found to be associated with aggressive biological behavior and poor prognosis of several types of malignancy. To evaluate the significance of the expression of multiple RTKs in uterine cervical cancers, we examined the expression profile of RTKs (EGFR, HER2 and c-Met) and the correlation of their expression with clinicopathological features and prognosis of patients with cervical adenocarcinomas...
2017: PloS One
https://www.readbyqxmd.com/read/28851324/cancer-incidence-in-eastern-morocco-cancer-patterns-and-incidence-trends-2005-2012
#15
Manal Elidrissi Errahhali, Mounia Elidrissi Errahhali, Meryem Ouarzane, Redouane Boulouiz, Mohammed Bellaoui
BACKGROUND: Cancer is one of the major health problems worldwide. In this article, we present for the first time the cancer incidence trends, the distribution and the socioeconomic profile of incident cancer cases in Eastern Morocco over a period of eight years. METHODS: Retrospective descriptive study of patients diagnosed with cancer at the Hassan II Regional Oncology Center (ROC) since it was created in October 2005 until December 2012. During the study period, the ROC was the only hospital specialized in cancer care in Eastern Morocco...
August 29, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28840302/comparison-of-18-f-fdg-pet-mri-and-mri-for-pre-therapeutic-tumor-staging-of-patients-with-primary-cancer-of-the-uterine-cervix
#16
Theresia Sarabhai, Benedikt M Schaarschmidt, Axel Wetter, Julian Kirchner, Bahriye Aktas, Michael Forsting, Verena Ruhlmann, Ken Herrmann, Lale Umutlu, Johannes Grueneisen
PURPOSE: The aim of the present study was to assess and compare the diagnostic performance of integrated PET/MRI and MRI alone for local tumor evaluation and whole-body tumor staging of primary cervical cancers. In addition, the corresponding impact on further patient management of the two imaging modalities was assessed. METHODS: A total of 53 consecutive patients with histopathological verification of a primary cervical cancer were prospectively enrolled for a whole-body 18F-FDG PET/MRI examination...
August 24, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28838412/intestinal-and-nonintestinal-cancer-risks-for-patients-with-crohn-s-disease
#17
REVIEW
Sushil K Garg, Fernando S Velayos, John B Kisiel
Crohn's disease (CD) is a chronic inflammatory disease that confers a higher risk of cancer than in the general population. New, large, population-based studies in the past decade show that patients with CD are at higher risk of colorectal, small bowel, melanoma, and cervical cancer. Patients who use thiopurines are at additional risk of development of lymphoma and nonmelanoma skin cancer. Preventive surveillance for cancers of the colorectum, skin, and uterine cervix is advised.
September 2017: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/28837714/change-in-pattern-of-secondary-cancers-after-kaposi-sarcoma-in-the-era-of-antiretroviral-therapy
#18
Fahad Mukhtar, Mmadili Ilozumba, Ovie Utuama, Oguz Cimenler
Importance: Studies performed in the 1980s and early 1990s have shown that people who develop Kaposi sarcoma (KS) are at higher risk of developing other cancers. The demographics of those affected with human immunodeficiency virus (HIV)/AIDS and KS have changed, and individuals with HIV/AIDS and KS now live longer. Objectives: To test the hypothesis that the secondary cancers developing in patients with KS have changed in recent years and to assess the risk of secondary cancers after KS in different periods...
August 24, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28819503/-neuroendocrine-carcinoma-of-the-cervix-a-case-report-and-review-of-the-literature
#19
REVIEW
Soufiane Baggar, Hajar Ouahbi, Meryem Azegrar, Fatima Zahra El M'rabet, Samia Arifi, Nawfel Mellas
Small cell neuroendocrine carcinomas of the gynecologic tract are unusual, accounting for only 2% of the cervical cancers. Given the rarity of these tumors and the absence of randomized trials, their diagnosis and treatment programmes are difficult and are essentially based on those of neuroendocrine tumors of the lung. As in the case of the neuroendocrine tumors of the lung and despite multimodal treatment they are associated with a poor prognosis. We here report a new case of small cell neuroendocrine carcinoma of the cervix and, throught a literature review, we highlight the various aspects of this rare entity...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28818111/estimates-of-cancer-incidence-and-mortality-in-china-2013
#20
Rongshou Zheng, Hongmei Zeng, Siwei Zhang, Wanqing Chen
INTRODUCTION: Population-based cancer registration data are collected by the National Central Cancer Registry in China every year. Cancer incident cases and cancer deaths in 2013 were analyzed. METHODS: Through the procedure of quality control, reported data from 255 registries were accepted to establish the national database for cancer estimates. Incidences and mortalities were calculated with stratification by area (urban/rural), sex (male/female), age group (0, 1-4, 5-9, 10-14 … 80-84, and 85-year-old and above), and cancer site...
August 17, 2017: Chinese Journal of Cancer
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