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https://www.readbyqxmd.com/read/29683262/celecoxib-enhances-the-therapeutic-efficacy-of-epirubicin-for-novikoff-hepatoma-in-rats
#1
Tian-Huei Chu, Hoi-Hung Chan, Tsung-Hui Hu, E-Ming Wang, Yi-Ling Ma, Shih-Chung Huang, Jian-Ching Wu, Yi-Chen Chang, Wen-Tsan Weng, Zhi-Hong Wen, Deng-Chyang Wu, Yi-Ming Arthur Chen, Ming-Hong Tai
Epirubicin is a chemotherapy agent for hepatocellular carcinoma (HCC). However, the outcome of HCC patients receiving epirubicin remains unsatisfactory. Moreover, our previous study indicated that celecoxib suppresses HCC progression and liver cancer stemness. This study evaluated the potential of celecoxib to serve as a complementary therapy during epirubicin treatment. Cell proliferation, apoptosis, invasiveness, and anchorage-independent growth were analyzed in hepatoma cells. Therapeutic efficacy was validated in rat orthotopic Novikoff hepatoma...
April 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29682988/impact-of-symptom-and-social-support-on-fertility-intention-in-reproductive-age-women-with-breast-cancer
#2
Sheng-Miauh Huang, Ling-Ming Tseng, Jerry Cheng-Yen Lai, Yi-Fang Tsai, Pei-Ju Lien, Ping-Ho Chen
This study describes the fertility intention and explores factors related to fertility intention in reproductive-age women with breast cancer in Taiwan. In this cross-sectional study, women of childbearing age who had been diagnosed with breast cancer completed a face-to-face survey that included demographic, disease, and symptom-related data, and social support and fertility intention information. The mean fertility intention score among the 223 participants was "medium" ( M ± SD = 41.18 ± 12.62)...
April 1, 2018: Clinical Nursing Research
https://www.readbyqxmd.com/read/29682886/a-common-regulatory-variant-in-slc35b4-influences-the-recurrence-and-survival-of-prostate-cancer
#3
Eric Y Huang, Yu-Jia Chang, Shu-Pin Huang, Victor C Lin, Chia-Cheng Yu, Chao-Yuan Huang, Hsin-Ling Yin, Ta-Yuan Chang, Te-Ling Lu, Bo-Ying Bao
Single nucleotide polymorphisms (SNPs) within the regulatory elements of a gene can alter gene expression, making these SNPs of prime importance for candidate gene association studies. We aimed to determine whether such regulatory variants are associated with clinical outcomes in three cohorts of patients with prostate cancer. We used RegulomeDB to identify potential regulatory variants based on in silico predictions and reviewed genome-wide experimental findings. Overall, 131 putative regulatory SNPs with the highest confidence score on predicted functionality were investigated in two independent localized prostate cancer cohorts totalling 458 patients who underwent radical prostatectomy...
April 23, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29681580/cancer-incidence-and-mortality-patterns-in-luwan-district-of-shanghai-during-2002-2011
#4
Jue Wang, Shuna Gao, Yejing Wang, Jianjun Zhou, Jing Lin, Ling Wang, Yan Du
Cancer has become the leading cause of death and a major burden to public health in China. The current study analyzed the composition, incidence, mortality, and temporal trends for some major cancer types among permanent residents in Luwan district of Shanghai from 2002 to 2011, so as to provide data for cancer research. Data were collected from the database of cancer registration and management system in Shanghai. Number of new cases, number of deaths, incidence, and mortality of each cancer type were calculated...
April 22, 2018: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/29680228/downregulation-of-cyclin-b1-mediated-nagilactone-e-induced-g2-phase-cell-cycle-arrest-in-non-small-cell-lung-cancer-cells
#5
Le-Le Zhang, Zhe-Ling Feng, Min-Xia Su, Xiao-Ming Jiang, Xiuping Chen, Yitao Wang, Ao Li, Li-Gen Lin, Jin-Jian Lu
Non-small cell lung cancer (NSCLC) is one of most common forms and leading causes of cancer-related mortality worldwide, and discovery of new effective drugs still remains imperative to improve the survival rate. Nagilactone E (NLE) is a natural product isolated from Podocarpus nagi seeds, which has been used as raw materials for edible oil and industrial oil extraction. This study aimed to investigate the anticancer potential of NLE against NSCLC A549 and NCI-H1975 cells. MTT assay revealed that NLE inhibited the proliferation of A549 and NCI-H1975 cells with IC50 s of 5...
April 19, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29680223/dysregulation-of-micrornas-in-autoimmune-diseases-pathogenesis-biomarkers-and-potential-therapeutic-targets
#6
Hai Long, Xin Wang, Yongjian Chen, Ling Wang, Ming Zhao, Qianjin Lu
MicroRNAs (miRNAs) are small, single-stranded, endogenous non-coding RNAs that repress the expression of target genes via post-transcriptional mechanisms. Due to their broad regulatory effects, the precisely regulated, spatial-specific and temporal-specific expression of miRNAs is fundamentally important to various biological processes including the immune homeostasis and normal function of both innate and adaptive immune response. Aberrance of miRNAs is implicated in the development of various human diseases, especially cancers...
April 19, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29679903/isoharringtonine-inhibits-breast-cancer-stem-like-properties-and-stat3-signaling
#7
Wei Chen, Hui Wang, Mei Cheng, Ling Ni, Li Zou, Qin Yang, Xianghai Cai, Baowei Jiao
OBJECTIVES: Breast cancer stem cells (BCSCs) contribute to breast cancer progression, relapse, and treatment resistance. Identification of the natural inhibitory components of BCSCs is therefore critical for clinical treatment. Here, we investigated whether isoharringtonine (IHT) had inhibitory effects on BCSCs in breast cancer cell lines. METHODS: HCC1806, HCC1937, and MCF7 cells were treated with IHT. The proliferation and the migration of cells were detected by MTS assay and wound healing migration assay, respectively...
April 18, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29679550/ct-guided-percutaneous-cryoablation-for-palliative-therapy-of-gastric-cancer-liver-metastases
#8
Xu Chang, Yan Wang, Hai-Peng Yu, Wei-Hao Zhang, Xue-Ling Yang, Zhi Guo
OBJECTIVE: Liver metastases occur in approximately 4%-14% of gastric cancer patients and are associated with high mortality. However, no standardized treatment approach is available for these patients. We aimed to assess the clinical outcomes of patients with gastric cancer liver metastases (GCLM) who underwent percutaneous cryoablation. METHODS: We retrospectively enrolled 19 patients with 27 metastatic hepatic tumors who underwent cryoablation for liver metastases after gastrectomy for primary gastric cancer...
April 18, 2018: Cryobiology
https://www.readbyqxmd.com/read/29678178/status-of-lipid-and-lipoprotein-in-female-breast-cancer-patients-at-initial-diagnosis-and-during-chemotherapy
#9
Xin Li, Zi-Li Liu, Yu-Tuan Wu, He Wu, Wei Dai, Bilal Arshad, Zhou Xu, Hao Li, Kai-Nan Wu, Ling-Quan Kong
BACKGROUND: The lipid profile status among breast cancer patients at initial diagnosis and during chemotherapy remain controversial. The aim of this study is to study the status of lipid and lipoprotein in female breast cancer patients at initial diagnosis and during chemotherapy. METHODS: We conducted a retrospective cohort study of the status of the lipid and lipoprotein in 1054 primarily diagnosed breast cancer patients and 2483 normal controls with age stratification, from July 2015 to October 2016...
April 20, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29677568/validation-of-the-cps-eg-and-neo-bioscore-staging-systems-after-preoperative-systemic-therapy-for-breast-cancer-in-a-single-center-in-china
#10
Ling Xu, Xuening Duan, Bin Zhou, Yinhua Liu, Jingming Ye, Zhaorui Liu, Chao Ma, Hong Zhang, Shuang Zhang, Lanbo Zhang, Jianxin Zhao, Yuanjia Cheng
BACKGROUND: Prognostic assessment after preoperative systemic therapy (PST) plays a vital role in determining treatment in breast cancer patients. Many researchers have sought to develop a system to quantitate residual tumor and its correlation with prognosis after PST. This retrospective study validated the CPS + EG staging system and Neo-Bioscore in a single center in China. METHODS: Data from patients with non-metastatic primary breast cancer who were treated with PST and surgery from Jan...
April 17, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29676233/chimeric-antigen-receptor-t-cell-based-immunotherapy-for-cancer
#11
Feng Li, Tengfei Zhang, Ling Cao, Yi Zhang
Cancer immunotherapy, a new weapon against cancers by harnessing the patient's own immune system, potentiates an extended remission and possibly a cure for cancer. T cells genetically engineered with chimeric antigen receptor (CAR) vectors can specifically target the surface antigen of cancer cells and kill them in an MHC-independent manner. CD19 is extensively expressed on cancerous cells in B cell malignancies. To target this antigen, CAR T cells have gained great success in treating patients with B cell leukemia and lymphoma...
April 19, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29676152/anti-cancer-effects-of-emodin-on-hepg2-cells-as-revealed-by-1h-nmr-based-metabolic-profiling
#12
Yue-Xiao Xing, Ming-Hui Li, Liang Tao, Ling-Yu Ruan, Wei Hong, Cheng Chen, Wen-Long Zhao, Han Xu, Jian-Feng Chen, Jun-Song Wang
Hepatic carcinoma is one of the most common cancers in the world with a high incidence. Emodin is an anthraquinone derived from Polygonum multiflorum Thunb, possessing anti-cancer activity. The purpose of this study is to investigate the anti-cancer effect of different dosages of emodin on HepG2 cells using 1H-NMR based metabolic approach complemented with qRT-PCR and flow cytometry to identify potential markers and discover the targets to explore the underlying mechanism. Emodin can dose-dependently inhibit the growth of HepG2 cells, perturb cell cycle progression, down-regulate the expression of genes and proteins related to glycolysis and trigger intracellular ROS generation...
April 20, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29673670/the-role-of-%C3%AE-2-3-linked-sialylation-on-clear-cell-type-epithelial-ovarian-cancer
#13
Pi-Lin Sung, Kuo-Chang Wen, Huann-Cheng Horng, Chia-Ming Chang, Yi-Jen Chen, Wen-Ling Lee, Peng-Hui Wang
OBJECTIVE: Our previous study has shown that high expression of α2,3-sialytransferase type I was associated with advanced stage serous type epithelial ovarian cancer (EOC). The aim of the current study further attempts to evaluate the altered α 2,3-sialylation on the behavior of clear cell type EOC (C-EOC). MATERIALS AND METHODS: Immunohistochemistry staining, bioinformatics analysis and tissue array were used to disclose the clinical significance of over α2,3-sialylation in C-EOC...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29673126/overexpression-of-hace1-in-gastric-cancer-inhibits-tumor-aggressiveness-by-impeding-cell-proliferation-and-migration
#14
Ying-Ling Chen, Dong-Ping Li, Hong-Yue Jiang, Yang Yang, Li-Li Xu, Shun-Cai Zhang, Hong Gao
HACE1 E3 ligase was discovered to be down-regulated in several cancers while its role in regulating tumors was merely understood. This study aimed to explore the specific effect of HACE1 played in gastric tumorigenesis and its potential mechanism. HACE1's expression was found significantly lower in gastric cancer tissues compared with the adjacent normal tissues (P < 0.001). Its protein level in gastric cancer negatively correlated to tumor pathological differentiation (P = 0.019). And in gastric cancer patients with TNM I-IIIa, those with lower HACE1 protein level had poorer overall survival (P = 0...
April 19, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29670373/positioning-error-and-expanding-margins-of-planning-target-volume-with-kilovoltage-cone-beam-computed-tomography-for-prostate-cancer-radiotherapy
#15
Gang Wang, Wen-Ling Wang, Yi-Qun Liu, Hong-Min Dong, Yin-Xiang Hu
Objective: In this study, prostate cancer patients were treated with image-guided radiotherapy (IGRT). The translational positioning errors were discussed to provide the basis for determining margins of the planning target volume (PTV). Methods: Thirty prostate cancer patients were treated with radical radiotherapy using the IGRT system. Patients were placed in the supine position and underwent kilovoltage cone beam computed tomography (KVCBCT) scans before radiotherapy...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29665788/medical-expenses-of-urban-chinese-patients-with-stomach-cancer-during-2002-2011-a-hospital-based-multicenter-retrospective-study
#16
Xiao-Jie Sun, Ju-Fang Shi, Lan-Wei Guo, Hui-Yao Huang, Neng-Liang Yao, Ji-Yong Gong, Ya-Wen Sun, Guo-Xiang Liu, A-Yan Mao, Xian-Zhen Liao, Ya-Na Bai, Jian-Song Ren, Xin-Yu Zhu, Jin-Yi Zhou, Ling Mai, Bing-Bing Song, Yu-Qin Liu, Lin Zhu, Ling-Bin Du, Qi Zhou, Xiao-Jing Xing, Pei-An Lou, Xiao-Hua Sun, Xiao Qi, Yuanzheng Wang, Rong Cao, Ying Ren, Li Lan, Kai Zhang, Jie He, Jia-Lin Wang, Min Dai
BACKGROUND: In China, stomach cancer is the third most common cancer and the third leading cause of cancer death. Few studies have examined Chinese stomach cancer patients' medical expenses and their associated trends. The Cancer Screening Program in Urban China (CanSPUC) is a Major Public Health Project funded by the central government. Through this project, we have extracted patients' medical expenses from hospital billing data to examine the costs of the first course treatments (which refers to 2 months before and 10 months after the date of cancer diagnosis) in Chinese patients with stomach cancer and the associated trends...
April 17, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29665476/bioactive-norditerpenoids-from-cephalotaxus-fortunei-var-alpina-and-c-lanceolata
#17
Ling Ni, Xiu-Hong Zhong, Xiao-Jiao Chen, Bing-Jie Zhang, Mei-Fen Bao, Xiang-Hai Cai
Twenty-eight naturally occurring Cephalotaxus tropone analogues, including 19 previously undescribed ones, were identified from Cephalotaxus fortunei Hook. var. alpina H. L. Li and C. lanceolata K. M. Feng. The presence of the C20 cephinoids A-E revealed that these tropones were assigned to the norditerpenoids and were perhaps derived from labdane-type diterpenoids. These norditerpenoids showed excellent cytotoxicity against human cancer cells (IC50 , 20-0.1 μM) in vitro. The SAR (structure-activity relationship) analysis disclosed that the tropone moiety and the lactone ring were crucial structural features for the observed activities...
April 14, 2018: Phytochemistry
https://www.readbyqxmd.com/read/29664240/polymorphisms-of-dna-repair-genes-are-associated-with-colorectal-cancer-in-patients-with-lynch-syndrome
#18
Abram B Kamiza, Ling-Ling Hsieh, Reiping Tang, Huei-Tzu Chien, Chih-Hsiung Lai, Li-Ling Chiu, Tsai-Ping Lo, Kuan-Yi Hung, Jeng-Fu You, Wen-Chang Wang, Chao A Hsiung, Chih-Ching Yeh
BACKGROUND: DNA repair genes are crucial for maintaining genomic stability by preventing mutagenesis and carcinogenesis. The present retrospective cohort study aimed at investigating whether MLH1, APEX1, MUTYH, OGG1, NUDT1, XRCC5, XPA, and ERCC2 single nucleotide polymorphisms (SNPs) are associated with colorectal cancer (CRC) in Chinese population with Lynch syndrome. METHODS: From Amsterdam criteria family registry, we identified 270 patients with Lynch syndrome...
April 17, 2018: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29662638/an-open-label-single-armed-exploratory-study-of-apatinib-a-novel-vegfr-2-tyrosine-kinase-inhibitor-in-patients-with-relapsed-or-refractory-non-hodgkin-lymphoma
#19
Ling Li, Sa Xiao, Lei Zhang, Xin Li, Xiaorui Fu, Xinhua Wang, Jingjing Wu, Zhenchang Sun, Xudong Zhang, Yu Chang, Feifei Nan, Jiaqin Yan, Zhaoming Li, Mengyuan Shi, Ken H Young, Mingzhi Zhang
Background: Apatinib, a novel small molecule vascular endothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase inhibitor, have shown remarkable efficacy in many solid cancers. But evidence of antitumor activity in patients with lymphoma is still limited. We conducted an open-label, single-armed, exploratory study in relapse or refractory non-Hodgkin lymphoma patients for the efficacy and safety of apatinib. Experimental design: Patients with relapse or refractory non-Hodgkin patients meet the criteria were eligible for enrollment...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29661228/mir-760-suppresses-human-colorectal-cancer-growth-by-targeting-batf3-ap-1-cyclind1-signaling
#20
Ling Cao, Yulin Liu, Dan Wang, Lan Huang, Feng Li, Jinbo Liu, Chaoqi Zhang, Zhibo Shen, Qun Gao, Weitang Yuan, Yi Zhang
BACKGROUND: Recent studies have reported that microRNAs (miRNAs) often function as negative post-transcriptional regulators with altered expression levels found in colorectal cancer (CRC). There have been few studies on miRNAs that regulate the oncogenic alterations in CRC. Here, we aim to explore the anti-cancer miRNA and the potential mechanisms by which miRNAs modulate CRC progression. METHODS: We performed an integrated analysis of CRC miRNA expression datasets in The Cancer Genome Atlas (TCGA)...
April 16, 2018: Journal of Experimental & Clinical Cancer Research: CR
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