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https://www.readbyqxmd.com/read/27925254/relative-tissue-distribution-and-excretion-studies-of-gastrodin-and-parishin-from-powder-and-extract-of-gastrodiae-rhizoma-in-rat-by-uhplc-esi-ms-ms
#1
Zhengmeng Jiang, Xiuyan Zheng, Xiaojian Gong, Chao Zhao, Xin Zhou, Yang Zhao, Yanfang Yan
New research indicated that Gastrodiae rhizome (GR) has potential anti-diabetic and anti-asthmatic effects in mice models. On the basis of our previously study of the relative bioavailability of gastrodin (GAS) and parishin (PA) from extract and powder of GR., we make further research on the tissue distribution and excretion studies of the two analytes. A reliable bioanalytical method for the quantification of GAS and PA in rat tissues and excretion is required. Chromatographic separation was carried out on a gradient mobile phase of acetonitrile-water with 0...
December 7, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27924952/a-competitive-bio-barcode-amplification-immunoassay-for-small-molecules-based-on-nanoparticles
#2
Pengfei Du, Maojun Jin, Ge Chen, Chan Zhang, Zejun Jiang, Yanxin Zhang, Pan Zou, Yongxin She, Fen Jin, Hua Shao, Shanshan Wang, Lufei Zheng, Jing Wang
A novel detection method of small molecules, competitive bio-barcode amplification immunoassay, was developed and described in this report. Through the gold nanoparticles (AuNPs) probe and magnetic nanoparticles (MNPs) probe we prepared, only one monoclonal antibody can be used to detect small molecules. The competitive bio-barcode amplification immunoassay overcomes the obstacle that the bio-barcode assay cannot be used in small molecular detection, as two antibodies are unable to combine to one small molecule due to its small molecular structure...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27923241/-comparison-of-psychosomatic-rehabilitation-for-german-and-foreign-patients
#3
P Zollmann, V Pimmer, A D Rose, S Erbstößer
Aim: This study aims to comprehensively analyse the course of psychosomatic rehabilitation - from access to quantifiable rehabilitation outcomes. A comparison is made between 3 groups of patients: German citizens, patients of Turkish nationality or patients of foreign or unknown nationality. Methods: The data set used comprises routine data of the German Pension Insurance regarding psychosomatic rehabilitation from the so called Reha-Statistik-Database (RSD, database for rehabilitation statistics) over a period from 2007 to 2014...
December 2016: Die Rehabilitation
https://www.readbyqxmd.com/read/27922062/enhanced-self-organized-dewetting-of-ultrathin-polymer-blend-film-for-large-area-fabrication-of-sers-substrate
#4
Huanhuan Zhang, Lin Xu, Yabo Xu, Gang Huang, Xueyu Zhao, Yuqing Lai, Tongfei Shi
We study the enhanced dewetting of ultrathin Polystyrene (PS)/Poly (methyl methacrylate) (PMMA) blend films in a mixed solution, and reveal the dewetting can act as a simple and effective method to fabricate large-area surface-enhanced Raman scattering (SERS) substrate. A bilayer structure consisting of under PMMA layer and upper PS layer forms due to vertical phase separation of immiscible PS/PMMA during the spin-coating process. The thicker layer of the bilayer structure dominates the dewetting structures of PS/PMMA blend films...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27920645/autoimmune-pancreatitis-a-case-of-atypical-radiographic-findings
#5
Shawhin Karimi, Parth Bharill
Autoimmune pancreatitis (AIP) is a rare pancreatic disorder that can present as a manifestation of a broader systemic inflammatory disease known as immunoglobulin G4-related systemic disease (IGG4-RSD). AIP is divided into two subtypes based on clinical, radiological, and histological findings. The disease can be mistaken for pancreatic cancer because of overlapping clinical and radiological findings, but early recognition can help avoid unnecessary surgery. We present a case of a 65-year-old female with suspected acute gallstone pancreatitis found to have AIP based on serology, radiological findings, and response to steroids...
September 2016: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/27914609/determination-of-diamondoids-in-crude-oils-using-gas-purge-microsyringe-extraction-with-comprehensive-two-dimensional-gas-chromatography-time-of-flight-mass-spectrometry
#6
Wanfeng Zhang, Shukui Zhu, Liling Pang, Xuanbo Gao, Gang-Tian Zhu, Donghao Li
Based on a homemade device, gas purge microsyringe extraction (GP-MSE) of crude oil samples was developed for the first time. As a simple, fast, low-cost, sensitive and solvent-saving technique, GP-MSE provides some outstanding advantages over the widely used sample preparation methods for crude oils such as column chromatography (ASTM D2549). Several parameters affecting extraction efficiency were optimized, including extraction temperature, extraction time, extraction solvent, condensing temperature and purge gas flow rate...
November 27, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27909730/a-sensitive-and-specific-indirect-competitive-enzyme%C3%A2-linked-immunosorbent-assay-for-the-detection-of-icariin
#7
Jinjun Cheng, Yue Zhang, Shuchen Liu, Baoping Qu, Meiling Zhang, Xiaoman Liu, Yan Zhao, Huihua Qu
In the present study, a novel monoclonal antibody (MAb) specific for icariin (ICA) was prepared and characterized. A hybridoma‑secreting MAb against icariin was produced by fusing splenocytes immunized with an ICA‑bovine serum albumin conjugate with a hypoxanthine‑aminopterin‑thymidine‑sensitive mouse myeloma SP2/0 cell line. The antibody showed high specificity for ICA with almost no cross‑reactivity against the majority of structurally‑related chemicals. Subsequently, an indirect competitive enzyme‑linked immunosorbent assay (ELISA) for ICA was established and characterized...
November 30, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27907030/sensitive-and-simplified-detection-of-antibiotic-influence-on-the-dynamic-and-versatile-changes-of-fecal-short-chain-fatty-acids
#8
Xiaoya Zhao, Zhenzuo Jiang, Fan Yang, Yan Wang, Xiumei Gao, Yuefei Wang, Xin Chai, Guixiang Pan, Yan Zhu
Short-chain fatty acids (SCFAs), produced by anaerobic fermentation of mainly indigestible dietary carbohydrates by gut microbiota, have a profound influence on intestinal function and host energy metabolism. Antibiotics may seriously disturb the balance of fecal SCFAs. To evaluate the impacts of antibiotics on fecal SCFAs produced by gut microbiota, a simple, reproducible and accurate gas chromatography (GC) method, which can simultaneously analyze seven SCFAs in fecal samples, was developed and validated...
2016: PloS One
https://www.readbyqxmd.com/read/27904080/an-ic-ms-ms-method-for-the-determination-of-1-hydroxyethylidene-1-1-diphosphonic-acid-on-uncooked-foods-treated-with-peracetic-acid-based-sanitizers
#9
Ippei Suzuki, Hiroki Kubota, Takashi Ohtsuki, Chiye Tatebe, Atsuko Tada, Takeo Yano, Hiroshi Akiyama, Kyoko Sato
A rapid, sensitive, and specific analytical method for the determination of 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) on uncooked foods after treatment with a peracetic acid-based sanitizer (PAS) was developed. The method involves simple sample preparation steps and analysis using ion chromatography (IC) coupled with tandem mass spectrometry (MS/MS). The quantification limits of HEDP on uncooked foods are 0.007 mg/kg for vegetables and fruits and 0.2 mg/kg for meats. The recovery and relative standard deviation (RSD) of HEDP analyses of uncooked foods ranged from 73...
2016: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27904079/application-of-response-surface-methodology-to-estimate-the-design-space-of-pharmaceutical-diluents-for-dispensing-powdered-formulations
#10
Yasunori Miyazaki, Kozo Takayama, Tomonobu Uchino, Yoshiyuki Kagawa
Scientific approaches for dispensation are important for the quality and efficacy of drug treatments. Therefore, for the dispensation of powdered medicines, we have developed a powder blending method using a planetary centrifugal mixer (PCM) to replace the empirical manual method involving a mortar and pestle. The aim of this study was to optimize the formulation of pharmaceutical diluents for dispensing powdered medicines, using PCM. The diluents, composed of powdered lactose, crystalline lactose, and corn starch were assigned to a {3,2}-Simplex Lattice design...
2016: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27886770/multiresidue-method-for-trace-pesticide-analysis-in-honeybee-wax-comb-by-gc-qqq-ms
#11
M D Gil García, S Uclés Duque, A B Lozano Fernández, A Sosa, A R Fernández-Alba
The aim of this analytical study is to develop an improved multi-residue methodology of high sensitivity and expanded scope for pesticide residue analysis in honeybee wax combs. The method was validated for 160 pesticide residues (including acaricides, insecticides, fungicides and herbicides) gas chromatography amenable and covering a wide variety of polarity and chemical structure. This method of analysis applied gas chromatography coupled to a triple quadrupole mass spectrometer for the quantitative analysis of pesticide residues...
January 15, 2017: Talanta
https://www.readbyqxmd.com/read/27886767/preparation-and-characterization-of-magnetic-molecularly-imprinted-polymers-for-the-extraction-of-hexamethylenetetramine-in-milk-samples
#12
Xing Xu, Emmanuel Duhoranimana, Xiaoming Zhang
Magnetic molecularly imprinted polymers (M-MIPs) were synthesized as the sorbents for extracting hexamethylenetetramine (HMT) from milk samples. Molecular simulations were used to calculate the interaction energies of the template monomers. The physical properties of M-MIPs were characterized. The adsorption isotherms and kinetics were investigated. Gas chromatography coupled with tandem mass spectrometry (GC-MS/MS) was applied to determine the amount of HMT residue in milk samples. In the optimized method, a linear calibration curve was obtained using a matrix-matched standard in the range of 1...
January 15, 2017: Talanta
https://www.readbyqxmd.com/read/27881490/new-micellar-electrokinetic-chromatographic-method-for-analyzing-idebenone-in-pediatric-formulations
#13
Mario Contin, Fabián Buontempo, Cristian García Becerra, Cecilia Dobrecky, Silvia Lucangioli, Valeria Tripodi
A novel, simple and reliable method based on micellar electrokinetic chromatography with ultraviolet detection was developed to analyze idebenone in a pediatric formulation. Idebenone is a synthetic short chain benzoquinone that acts as an electron carrier in the mitochondrial electron transport chain facilitating the production of adenosine triphosphate. It can be found in two different redox states that differ in their physiological properties. Idebenone has been investigated as a treatment in several neurological disorders like Friedreich's ataxia, Leber's hereditary optic neuropathy, mitochondrial encephalomyopathies and senile dementia...
November 23, 2016: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/27881283/cost-effectiveness-of-introducing-point-of-care-test-for-detection-of-level-of-glycogen-phosphorylase-in-early-diagnostic-algorithm-of-acute-coronary-syndrome
#14
Slobodan M Janković, Marina Kostić
BACKGROUND: The detection of specific biomarkers in the early phase of acute coronary syndrome (ACS) is important for the early diagnosis and appropriate management of patients with ACS. OBJECTIVES: To estimate the cost-effectiveness of introducing a diagnostic point-of-care (POC) test for determining the levels of glycogen phosphorylase BB isoform (GPBB) in a standard diagnostic algorithm for the early diagnosis of ACS within the health system of the Republic of Serbia...
September 2016: Value in Health Regional Issues
https://www.readbyqxmd.com/read/27874826/optimization-and-validation-of-a-fast-uplc-method-for-simultaneous-determination-of-hydroquinone-kojic-acid-octinoxate-avobenzone-bha-and-bht
#15
Fanny Galimany-Rovira, Montse Miñarro-Carmona, Pilar Pérez-Lozano, Encarna García-Montoya, Josep R Ticó-Grau, Josep M Suñé-Negre
A previously published HPLC method for the simultaneous determination of six major components (hydroquinone, kojic acid, octinoxate, avobenzone, butylated hydroxyanisole, and butylated hydroxytoluene) in a skin-whitening cream was transferred and optimized to an ultra-performance LC system. Separation was achieved in a ZORBAX SB-Phenyl Rapid-Resolution High Throughput column (2.1 × 100 mm, 1.8 μm), using a mobile phase consisting of water with 0.1% acetic acid and acetonitrile at a flow rate of 0.7 mL/min...
September 29, 2016: Journal of AOAC International
https://www.readbyqxmd.com/read/27871614/direct-lead-isotope-analysis-in-hg-rich-sulfides-by-la-mc-icp-ms-with-a-gas-exchange-device-and-matrix-matched-calibration
#16
Wen Zhang, Zhaochu Hu, Detlef Günther, Yongsheng Liu, Wenli Ling, Keqing Zong, Haihong Chen, Shan Gao
In situ Pb isotope data of sulfide samples measured by LA-MC-ICP-MS provide valuable geochemical information for studies of the origin and evolution of ore deposits. However, the severe isobaric interference of (204)Hg on (204)Pb and the lack of matrix-matched sulfide reference materials limit the precision of Pb isotopic analyses for Hg-rich sulfides. In this study, we observe that Hg forms vapor and can be completely removed from sample aerosol particles produced by laser ablation using a gas exchange device...
December 15, 2016: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27869552/validation-of-a-method-for-sedatives-and-%C3%AE-blockers-determination-in-swine-bovine-and-equine-kidney-using-liquid-chromatography-coupled-with-tandem-mass-spectrometry
#17
Lenise Guimarães de Oliveira, Fabiano Barreto, Rodrigo Hoff, Gabriel Rübensam, Marcia Helena Scherer Kurz, Gabriela Galle, Fábio Ferreira Gonçalves
A method for the determination of five sedatives and 14 β-blocker residues in swine, bovine and equine kidney was validated. Samples were extracted with acetonitrile and purified using dispersive solid phase extraction (d-SPE) with Celite 545 with subsequent analysis by LC-MS/MS. A simplified protocol was applied to validate the method scope extension to include new matrices. Parameters such as recovery, trueness, linearity (r(2)), relative standard deviation (RSD), decision limit (CCα) and method capability (CCβ) were measured for the bovine and equine kidney matrices...
November 21, 2016: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/27868209/determination-of-lithium-and-transition-metals-in-li1-ni1-3-co1-3-mn1-3-o2-ncm-cathode-material-for-lithium-ion-batteries-by-capillary-electrophoresis
#18
Britta Vortmann-Westhoven, Constantin Lürenbaum, Martin Winter, Sascha Nowak
In this work we present a novel electrophoretic method that was developed for the determination of lithium and transition metals in LiNi1/3 Co1/3 Mn1/3 O2 (NCM) cathode material after microwave digestion. The cations in the digested NCM material was separated by capillary electrophoresis (CE) and the element content was determined by UV/Vis detection. To characterize the precision of the measurements, the relative standard deviations (RSD) and concentrations were calculated and compared to those obtained with inductively coupled plasma - optical emission spectrometry (ICP-OES)...
November 21, 2016: Electrophoresis
https://www.readbyqxmd.com/read/27867277/characterization-and-bioavailability-study-of-baicalin-mesoporous-carbon-nanopowder-solid-dispersion
#19
Li Cui, E Sune, Jie Song, Jing Wang, Xiao-Bin Jia, Zhen-Hai Zhang
BACKGROUND: Baicalin is the main bioactive constitute of the dried roots of Scutellaria baicalensis and possesses various biological activities. However, the poor water solubility and low oral bioavailability limit its efficacy. OBJECTIVE: The present study was conducted to enhance the dissolution and oral bioavailability of baicalin (BA) through a novel mesoporous carbon nanopowder (MCN) drug carrier. MATERIALS AND METHODS: Solid dispersions (SDs) of BA with MCN were prepared using a solvent evaporation method...
October 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27862112/qualitative-and-quantitative-analysis-of-major-constituents-from-dazhu-hongjingtian-capsule-by-uplc-q-tof-ms-ms-combined-with-uplc-qqq-ms-ms
#20
Guang-Da Liu, Yi-Wu Zhao, Yan-Jing Li, Xue-Jing Wang, Hai-Hong Si, Wen-Zhe Huang, Zhen-Zhong Wang, Shi-Ping Ma, Wei Xiao
In this work, a sensitive and efficient method was established and validated for qualitative and quantitative analysis of major bioactive constituents in Dazhu Hongjingtian capsule by liquid chromatography tandem mass spectrometry (LC-MS). A total of 32 compounds were tentatively identified using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF MS/MS). Furthermore, twelve constituents, namely gallic acid, 3,4-dihydroxybenzoic acid, salidroside, p-coumaric acid-4-O-β-D-glucopyranoside, bergeninum, 4-hydroxybenzoic acid, 4-hydroxyphenylacetic acid, syringate, 6''-O-galloylsalidroside, rhodiosin, rhodionin and kaempferol-7-O-α-L-rhamnoside, were simultaneously quantified by the developed ultra-performance liquid chromatography coupled with a triple quadrupole mass spectrometry (UPLC-QQQ-MS/MS) method in 9 min...
November 9, 2016: Biomedical Chromatography: BMC
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