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Zhi-Jiang He, Wen Li, Hua Chen, Jian Wen, Yan-Feng Gao, Yun-Jun Liu
This study aimed to elucidate the effect of miR-1306-3p on metastasis of hepatocellular carcinoma (HCC) and potential mechanism involved. miR-1306-3p promoted migration and invasion of HCC in vivo and in vitro. Moreover, miR-1306-3p inhibited snail to enhance its expression via directly targeting FBXL5, thus inducing the epithelial-mesenchymal transition (EMT) in HCC. Intriguingly, miR-1306-3p expression was transcriptionally enhanced by FoxM1. Consistently, miR-1306-3p was upregulated in HCC compared with paracarcinoma and correlated with poor prognosis of HCC patients...
September 12, 2018: Biochemical and Biophysical Research Communications
Jingyu Xu, Wei Shen, Bei Pei, Xiaowei Wang, Dazhi Sun, Yongjin Li, LiJuan Xiu, Xuan Liu, Ye Lu, Xuan Zhang, XiaoQiang Yue
In recent years, Chinese medicine has played an important role in the prognosis of gastric cancer. Precancerous lesions of gastric carcinoma (PLGC) is a class of gastric cancer which is closely related to the gastric mucosal pathology changes in the role of carcinogenic incentives, and plays key role in the progression of normal gastric mucosal cells into gastric cancerous cells. In current experiment, we explore the relationship between Chinese traditional medicine (Xiao Tan He Wei Decoction) and gastric cancer in the PLGC rat animal models and epithelial-mesenchymal transitioned GES-1 cells which were induced useing 1- Methyl-3-nitro-1-nitrosoguanidine (MNNG)...
September 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Rosario Castro-Oropeza, Jorge Melendez-Zajgla, Vilma Maldonado, Karla Vazquez-Santillan
BACKGROUND: Tumors contain a functional subpopulation of cells that exhibit stem cell properties. These cells, named cancer stem cells (CSCs), play significant roles in the initiation and progression of cancer. Long non-coding RNAs (lncRNAs) can act at the transcriptional, posttranscriptional and translational level. As such, they may be involved in various biological processes such as DNA damage repair, inflammation, metabolism, cell survival, cell signaling, cell growth and differentiation...
September 14, 2018: Cellular Oncology (Dordrecht)
Snehalatha Diddi, Swarna Bale, Gauthami Pulivendala, Chandraiah Godugu
BACKGROUND: Clinical manifestations of skin fibrosis are very variable and ambiguous, making its management quite critical and challenging. The lack of appropriate established pharmacological interventions make its treatment even more complicated. Intricate details of the underlying pathogenesis are thus imperative to further explore different treatment possibilities. Of note, the TGF-β/Smad signaling axis and epithelial to mesenchymal transition (EMT) are the principal offenders in this fibrotic disorder...
September 14, 2018: Inflammopharmacology
Chih-Chan Lee, Jiunn-Chang Lin, Wei-Lun Hwang, Ying-Ju Kuo, Hung-Kai Chen, Shyh-Kuan Tai, Chun-Chi Lin, Muh-Hwa Yang
A favorable interplay between cancer cells and the tumor microenvironment (TME) facilitates the outgrowth of metastatic tumors. Because of the distinct initiating processes between primary and metastatic tumors, we investigate the differences in tumor-associated macrophages (TAMs) from primary and metastatic cancers. Here we show that dual expression of M1 and M2 markers is noted in TAMs from primary tumors, whereas predominant expression of M2 markers is shown in metastatic TAMs. At metastatic sites, TAMs secrete interleukin-35 (IL-35) to facilitate metastatic colonization through activation of JAK2-STAT6-GATA3 signaling to reverse epithelial-mesenchymal transition (EMT) in cancer cells...
September 14, 2018: Nature Communications
Siying Zhou, Yunjie He, Sujin Yang, Jiahua Hu, Qian Zhang, Wei Chen, Hanzi Xu, Heda Zhang, Shanliang Zhong, Jianhua Zhao, Jinhai Tang
Breast cancer (BC) is the most common cancer and principal cause of death among females worldwide. Invasion and metastasis are major causes which influence the survival and prognosis of BC. Therefore, to understand the molecule mechanism underlying invasion and metastasis is paramount for developing strategies to improve survival and prognosis in BC patients. Recent studies have reported that long non-coding RNAs (lncRNAs) play critical roles in the regulation of BC invasion and metastasis through a variety of molecule mechanisms that endow cells with an aggressive phenotype...
September 14, 2018: Bioscience Reports
Yin-Xue Song, Zhi-Chao Xu, Hui-Ling Li, Pei-Lei Yang, Jun-Kai Du, Jing Xu
Pancreatic cancer is one of the most difficult clinical cases to diagnose with a very low 5-year survival rate of 5%, regardless of the advances made in both the medical and surgical treatment of the disease. One of the contributing factors for the high mortality rate seen of pancreatic cancer patients is the lack of effective chemotherapies, which is believed to be due to drug-resistance. Based on recent evidence, epithelial-mesenchymal transition (ETM) of pancreatic cancer cells has been found to be associated with the development of drug resistance and an increase in cell invasion...
August 23, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Sameer Abdallah Dhayat, Max Michael Traeger, Jan Rehkaemper, Anda Jana Stroese, Konrad Steinestel, Eva Wardelmann, Iyad Kabar, Norbert Senninger
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive carcinoma entities worldwide with early and rapid dissemination. Recently, we discussed the role of microRNAs as epigenetic regulators of Epithelial-to-Mesenchymal Transition (EMT) in PDAC. In this study, we investigated their value as diagnostic and prognostic markers in tissue and blood samples of 185 patients including PDAC, non-malignant pancreatic disorders, and age-matched healthy controls. Expression of the microRNA-200-family (microRNAs -141, -200a, -200b, -200c, -429) and microRNA-148a was significantly downregulated in tissue of PDAC Union internationale contre le cancer (UICC) Stage II...
September 13, 2018: Cancers
Xiao-Feng Xu, Jian-Jiang Wang, Li Ding, Jin-Song Ye, Li-Juan Huang, Lan Tao, Feng Gao, Yong Ji
Gastric cancer (GC) is one of the main causes of cancer-related mortality worldwide. Epithelial-mesenchymal transition (EMT) is an important biological process involving the process by which malignant tumor cells obtain the ability of migration, invasion, resistance of apoptosis, and degradation in the extracellular matrix. The current study aimed at investigating whether bone marrow X kinase Rho GTPase activating protein 12 (BMX-ARHGAP) fusion gene affects GC. First, short hairpin RNA (shRNA) against BMX-ARHGAP or BMX-ARHGAP were introduced to treat SGC-7901 cells with the highest BMX-ARHGAP among the five GC cell lines (SGC-7901, MKN-45, NCI-N87, SNU-5, and AGS)...
September 14, 2018: Journal of Cellular Biochemistry
Ji-Hoon Jeong, Hae Jin Jang, Sungmin Kwak, Gi-Jun Sung, Seung-Ho Park, Ji-Hye Song, Hyunhee Kim, Younghwa Na, Kyung-Chul Choi
Transforming growth factor β1 (TGF-β1), a multifunctional cytokine, is known to promote tumor invasion and metastasis and induce epithelial-mesenchymal transition (EMT) in various cancer cells. Inhibition of TGF-β1 signaling is a new strategy for cancer therapy. Most cancer cells display altered or nonfunctional TGF-β1 signaling; hence, TGF-β1 inhibitors exert limited effects on these cells. Recent studies have suggested that developing a TGF-β1 inhibitor from natural compounds is a key step to create novel therapeutic agents...
September 14, 2018: Journal of Cellular Biochemistry
Xiao-Jun Ge, Li-Mei Zheng, Zhong-Xin Feng, Mei-Yong Li, Lan Liu, Yu-Jie Zhao, Jun-Yao Jiang
Recent studies have demonstrated that the overexpression of H19 may contribute towards development of tumorigenesis in various types of cancer. To investigate the role of H19 in the development of non-small cell lung cancer (NSCLC), 76 NSCLC tissues samples and their adjacent normal tissue samples were collected. Expression level of H19, and its association with clinicopathological features and overall survival was analyzed. It was found that compared with normal adjacent tissues, H19 expression was elevated in NSCLC tissues along with a decreased miR-203 expression level...
October 2018: Oncology Letters
Xianping Wang, Xufeng Ding, Xiao Xiao, Fang Xiong, Rui Fang
The aim of the present study was to explore the influence of positive simple thyroid peroxidase antibody (TPO-Ab) on female infertility. Venous blood was collected on an empty stomach from infertile female patients (all of whom were in line with the World Health Organization's diagnostic criteria for infertility) receiving treatments at The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University from 2014 to 2017 to detect thyroid function and thyroid antibodies [thyroglobulin antibody (TG-Ab), TPO-Ab and thyroid microsome antibody (TM-Ab)]...
October 2018: Experimental and Therapeutic Medicine
Kewei Zhang, Yang Li, Limei Qu, Xiaobo Ma, Hongguang Zhao, Ying Tang
Background: Long noncoding RNA (lncRNA) Sox2 overlapping transcript (SOX2OT) has been reported to be upregulated in various types of cancers, including non-small-cell lung cancer (NSCLC). However, the biological role and underlying mechanism of SOX2OT activity in NSCLC remain largely unknown. This study aims to investigate the function and possible molecular mechanisms of SOX2OT in NSCLC. Materials and methods: Quantitative real-time polymerase chain reaction was used to detect SOX2OT expression, and cellular proliferation, migration, and invasion were measured using cell counting kit-8, wound healing, and Transwell invasion assays, respectively...
2018: OncoTargets and Therapy
Ho-Ryun Won, Sung Un Kang, Haeng Jun Kim, Jeon Yeob Jang, Yoo Seob Shin, Chul-Ho Kim
Adequate and rapid mucosal regeneration is one of the most important factors in the healing process of nasal mucosa after surgery or trauma. In particular, delayed mucosal regeneration after surgery is an important cause of surgical failure. However, no effective treatment is available yet. Non-thermal plasma (NTP) has several medical effects, but the existing probe type is limited to local direct treatment. Therefore, we investigated the various effects using liquid type plasma to overcome this limitation...
September 13, 2018: Scientific Reports
Thomas J Rogers, Jessica L Christenson, Lisa I Greene, Kathleen I O'Neill, Michelle M Williams, Michael A Gordon, Travis Nemkov, Angelo D'Alessandro, Greg D DeGala, Jimin Shin, Aik-Choon Tan, Diana M Cittelly, James R Lambert, Jennifer K Richer
Tryptophan-2,3-dioxygenase (TDO2), a rate-limiting enzyme in the tryptophan catabolism pathway, is induced in triple-negative breast cancer (TNBC) by inflammatory signals and anchorage-independent conditions. TNBC express extremely low levels of the microRNA-200 (miR-200) family compared to estrogen receptor-positive (ER+) breast cancer. In normal epithelial cells and ER+ breast cancers and cell lines, high levels of the family member, miR-200c serve to target and repress genes involved in epithelial-to-mesenchymal transition (EMT)...
September 13, 2018: Molecular Cancer Research: MCR
Jae-Rim Heo, Kyung-A Hwang, Seung U Kim, Kyung-Chul Choi
Purpose: In the present study, human neural stem cells (hNSCs) with tumor-tropic behavior were used as drug delivery vehicle to selectively target melanoma. A human neural stem cell line (HB1.F3) was transduced into two types: one expressed only the cytosine deaminase (CD) gene (HB1.F3.CD) and the other expressed both CD and human interferon-β (IFN-β) genes (HB1.F3.CD.IFN-β). Materials and Methods: This study verified the tumor-tropic migratory competence of engineered hNSCs on melanoma (A375SM) using a modified Boyden chamber assay in vitro and CM-DiI staining in vivo...
September 14, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Herman Alexander Jaeger, Pádraig Cantillon-Murphy
Electromagnetic tracking (EMT) is playing an increasingly important role in surgical navigation, medical robotics and virtual reality development as a positional and orientation reference. Though EMT is not restricted by line-of-sight requirements, measurement errors caused by magnetic distortions in the environment remain the technology's principal shortcoming. The characterisation, reduction and compensation of these errors is a broadly researched topic, with many developed techniques relying on auxiliary tracking hardware including redundant sensor arrays, optical and inertial tracking systems...
September 12, 2018: Sensors
Xixi Zhao, Jingkun Qu, Xu Liu, Jizhao Wang, Xingcong Ma, Xiaoyao Zhao, Qian Yang, Wanjun Yan, Zitong Zhao, Yuxin Hui, Haocheng Bai, Shuqun Zhang
Tumor associated macrophages (TAMs) are the main infiltrating component in the tumor microenvironment and play an important role in cancer progression. Baicalein has a wide range of pharmacological properties. This study explores the potential effect of baicalein on macrophages polarization and epithelial-mesenchymal transition (EMT) of breast cancer. Co-culture system was established to evaluate the interaction between TAMs and breast cancer cells. Then the role of baicalein in modulating TAMs function was assessed...
2018: American Journal of Cancer Research
Lan Mi, Kai Hu, Xianzi Wen, Jing Sun, Aiwen Wu, Mingliang Wang, Minhua Zheng, Lu Zang, Jiafu Ji
The function and clinical implication of transcription factor CCAAT/enhancer-binding protein α (C/EBPα) in colorectal cancer (CRC) still remains undefined. In fact, C/EBPα has long been considered as a tumor suppressor in hematopoietic system and also found lowly expressed in numerous solid tumors. However, our results here for the first time showed that C/EBPα was unexpectedly upregulated and was an independent prognostic marker for patients with CRC. We therefore aimed to explore the detailed role and mechanisms of C/EBPα in CRC...
2018: American Journal of Cancer Research
Lina Yang, Yi Fan, Xiuli Zhang, Lili Gao, Jianfei Ma
OBJECTIVE: To explore the effects of miRNA-21/phosphatase and tensin homolog (PTEN) on the high glucose-stimulated epithelial-to-mesenchymal transition (EMT) in human peritoneal mesothelial cells (HPMCs). METHODS: HPMCs were cultured under control conditions, or with high glucose (HG), HG with miRNA-21 mimic or a miRNA-21 inhibitor. Expression of miRNA-21, α-smooth muscle actin, >fibronectin, E-cadherin and PTEN were measured by real time PCR, Western blotting and immunofluorescence staining...
2018: American Journal of Translational Research
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